@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0829: (2015-12-03 )
MKELSSAQIRQMWLDFWKSKGHSVEPSANLVPVNDPTLLWINSGVATLKKYFDGSVIPENPRITNAQKSIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRDEAIEWGFELLTSPEWFDFPKDKLYMTYYPDDKDSYNRWIACGVEPSHLVPIEDNFWEIGAGPSGPDTEIFFDRGEDFDPDNIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKELPNKNIDTGAGLERLAAVMQGAKTNFETDLFMPIIREVEKLSGKTYDPDGDNMSFKVIADHIRALSFAIGDGALPGNEGRGYVLRRLLRRAVMHGRRLGINETFLYKLVPTVGQIMESYYPEVLEKRDFIEKIVKREEETFARTIDAGSGHLDSLLAQLKAEGKDTLEGKDIFKLYDTYGFPVELTEELAEDAGYKIDHEGFKSAMKEQQDRARAAVVKGGSMGMQNETLAGIVEESRFEYDTYSLESSLSVIIADNERTEAVSEGQALLVFAQTPFYAEMGGQVADTGRIKNDKGDTVAEVVDVQKAPNGQPLHTVNVLASLSVGTNYTLEINKERRLAVEKNHTATHLLHAALHNVIGEHATQAGSLNEEEFLRFDFTHFEAVSNEELRHIEQEVNEQIWNALTITTTETDVETAKEMGAMALFGEKYGKVVRVVQIGNYSVELCGGTHLNNSSEIGLFKIVKEEGIGSGTRRIIAVTGRQAFEAYRNQEDALKEIAATVKAPQLKDAAAKVQALSDSLRDLQKENVELKEKAAAAAAGDVFKDIQEAKGVRFIASQVDVADAGALRTFADNWKQKDYSDVLVLVAAIGEKVNVLVASKTKDVHAGNMIKGLAPIVAGRGGGKPDMAMAGGSDASKIAELLAAVAENL
Atome Classification :
(23 SA)
.........10........20........30........40........50...-.....--60........70.----.......80........90.......-----.100.......110.......120.......130.......140-..-.......150.---------.--------.-....160.-.......170.......180.......190.......200.......210....----....-------.220.......230.......240....---------------------...250.......260.......270-----------------------------------------------..-...--------------------------...280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420--.......430..-.....440.....-..450.......460.....---...470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640...-...--.650........660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKE
L
S
S
A
Q
I
R
Q
M
W
L
D
F
W
K
SKGHSVEPSA
N
L
V
PVND
P
T
L
L
W
INS
G
V
A
T
L
K
K
YFDG-SVIPE--NPRIT
N
A
Q
KSIRT----N
D
I
E
N
V
G
K
T
A
R
H
H
T
M
F
E
M
L
GNFS
I
G
D
-----
Y
F
R
D
E
A
I
E
W
G
F
E
LLTSPEWFDFPKD
K
L
Y
M
T
YYPDDKDSYN
R
W
---
I
A-CGVEP
S
H
L
VPI---------E--------D-N
F
W
EIG-A-GPSGPDT
E
I
F
F
DRGEDFDPD
N
I
G
L
R
L
L
A
E
D
IEND
R
Y
I
E
I
W
N
I
V
L
S
QFN--ADPA----V
P
R
S
-------
E
Y
K
ELPNKNIDT
G
A
G
L
E
R
L
A
A
V
M
QGAKT---------------------NFE
T
D
L
F
M
P
I
I
R
E
V
E
K
LSGKTYDPD------------------------------------------------GD-N
M
S
--------------------------
F
K
V
I
A
D
H
I
R
A
L
S
F
AIGDGALPGNEG
R
G
Y
V
L
R
R
L
L
R
R
A
V
MHGRRLGI
N
E
T
F
L
Y
K
L
V
P
T
V
G
Q
I
M
E
S
Y
Y
P
E
V
L
E
K
R
D
F
I
E
K
I
V
K
R
E
E
E
T
F
A
RTIDAGS
G
H
L
D
S
L
L
A
Q
L
KAEGKDTLEG
K
D
I
F
K
L
Y
D
TYGF
P
V
E
L
T
E
E
L
A
E
DAGYKI
D
H
E
--
G
F
K
S
A
M
K
E
Q
Q
D
R
-
A
R
A
A
V
VKGGSMGM-QN
E
T
L
A
G
I
V
E
E
SR-FEYDTY---SLES
S
L
S
V
I
I
ADNERTEAVSEG
Q
A
L
L
V
F
AQTP
F
Y
A
E
MGGQVADTGRIKNDKG
D
T
V
A
E
V
V
D
V
QKAPNGQP
L
H
T
V
N
V
L
A
S
LSVG
T
N
Y
T
L
E
INKE
R
R
L
A
VEKN
H
T
A
T
H
L
L
H
A
A
L
H
N
V
I
G
E
HATQAGSL
N
E
E
E
F
L
R
F
D
F
T
H
F
EAV
S
N
E
E
L
R
H
I
E
Q
E
V
N
E
Q
I
W
N
A
L
T
I
T
TTE
T
D
V
E
T
A
K
E
M
G
A
M
-
A
L
F
--
G
E
K-Y
G
K
V
V
R
V
V
Q
IG
N
Y
S
V
E
LCGGTHLNNSSEI
G
L
F
K
I
V
KEEGIGSG
T
R
R
I
I
A
VT
G
R
Q
A
F
E
A
YR
N
Q
E
D
A
L
K
E
I
A
A
T
VKAP
Q
L
K
D
A
A
A
K
V
Q
A
L
S
D
S
L
R
D
L
Q
K
E
N
V
E
L
K
E
K
A
AAAA
A
G
D
V
F
K
D
I
Q
E
AKG
V
R
F
I
A
SQVDVAD
A
G
A
L
R
T
F
A
D
NWKQK
D
Y
S
D
V
L
V
L
V
A
A
IGE
K
V
N
V
L
V
A
SKTKDVHAG
N
M
I
K
G
L
A
P
I
VAGRGGGKPD
M
A
MAGGS
D
A
S
K
I
A
E
L
L
A
A
V
AENL
33
HHSearch
94.59
28%
-67
* C2 *
3WQY
1
SYA_ARCFU
A:
[57-901]
K
K
P
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
G
V
A
P
P
P
--
A
N
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
E
---
L
G
V
K
K
E
D
I
V
-----------------------------
Y
----------
K
--------
E
-
E
P
W
A
G
G
---
G
N
A
G
P
C
L
E
A
I
V
G
-----------------------
G
L
E
V
A
T
L
V
F
M
N
L
E
--
E
H
P
-------
E
G
DIEIKG
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
---------------------
V
Y
D
A
-
I
F
P
E
V
V
D
T
I
I
D
N
S
N
V
S
F
N
R
E
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
RG
E
R
L
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
P
-
L
E
K
--------------------------
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
E
L
G
L
-
D
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
---
E
F
D
V
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
R
L
V
E
R
-----
K
K
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
K
D
I
Y
A
E
L
A
K
R
H
S
K
A
-
E
K
V
-
Q
E
K
K
--
I
------
T
L
Q
N
E
Y
P
A
T
E
K
L
Y
Y
D
D
P
TLL
E
F
E
A
E
V
I
G
V
E
------------
G
D
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
--
G
K
F
E
V
V
D
V
L
E
-
A
D
G
V
V
L
H
V
V
K
G
-
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
R
L
Y
Q
--
G
G
V
P
P
G
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
-
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
-
A
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
G
-
A
-
V
G
C
L
M
A
K
G
E
G
K
V
F
V
V
T
F
-
S
G
Q
K
Y
D
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
D
V
I
F
R
F
L
15
PsiBlast_PDB
90.03
26%
-56
- C2 -
3WQY
1
SYA_ARCFU
A:
[64-880]
-------
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
-
G
V
A
P
P
PA
N
P
-
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
E
--------------------------------
L
G
V
K
K
E
D
I
V
Y
K
---------
E
--------
E
-
P
W
--
A
G
-
G
-
G
N
A
G
P
C
L
E
A
I
V
G
----------
G
L
-------------
E
V
A
T
L
V
F
M
N
L
E
--
E
H
P
E
GDIE
I
K
G
A
-------
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
V
Y
D
A
I
F
P
E
V
V
D
T
I
I
D
N
SNVSF
N
R
E
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
R
------------------------------------------------
G
E
-
R
L
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
E
L
G
L
D
-
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
E
F
D
V
P
L
S
T
---
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
R
L
V
-----
E
R
K
K
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
----
K
D
I
Y
A
E
L
A
K
R
H
S
K
A
E
K
V
Q
E
K
K
I
T
L
-
Q
N
E
Y
P
A
---
T
E
K
L
-
Y
Y
D
D
P
T
---
L
L
E
F
E
A
E
V
I
G
V
E
G
D
----------
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
--
E
V
V
D
V
L
E
A
-
D
G
V
V
L
H
V
V
K
G
-
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
-
R
L
Y
QG
G
V
P
-
P
G
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
A
K
-
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
-
A
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
G
A
V
G
C
L
M
---
A
K
G
E
G
K
V
F
V
V
T
F
S
G
Q
K
Y
D
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
D
V
I
F
R
F
L
16
PsiBlast_PDB
88.00
26%
-57
- C2 -
3WQZ
2
SYA_ARCFU
A:
[64-880]
-------
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
-
G
V
A
P
P
PA
N
P
-
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
E
--------------------------------
L
G
V
K
K
E
D
I
V
Y
K
---------
E
--------
E
-
P
W
--
A
G
-
G
-
G
N
A
G
P
C
L
E
A
I
V
G
----------
G
L
-------------
E
V
A
T
L
V
F
M
N
L
E
--
E
H
P
E
GDIE
I
K
G
A
-------
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
V
Y
D
A
I
F
P
E
V
V
D
T
I
I
D
N
SNVSF
N
R
E
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
R
------------------------------------------------
G
E
-
R
L
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
E
L
G
L
D
-
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
E
F
D
V
P
L
S
T
---
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
R
L
V
-----
E
R
K
K
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
----
K
D
I
Y
A
E
L
A
K
R
H
S
K
A
E
K
V
Q
E
K
K
I
T
L
-
Q
N
E
Y
P
A
---
T
E
K
L
-
Y
Y
D
D
P
T
---
L
L
E
F
E
A
E
V
I
G
V
E
G
D
----------
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
--
E
V
V
D
V
L
E
A
-
D
G
V
V
L
H
V
V
K
G
-
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
-
R
L
Y
QG
G
V
P
-
P
G
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
L
R
V
E
P
A
K
-
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
-
A
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
G
A
V
G
C
L
M
---
A
K
G
E
G
K
V
F
V
V
T
F
S
G
Q
K
Y
D
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
D
V
I
F
R
F
L
36
HHSearch
84.84
45%
-63
- C2 -
1YFS
1
SYA_AQUAE
A:
[2-458]
--
S
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
--
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
E
--
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
---
N
E
H
I
G
I
P
S
E
R
I
W
R
L
---------
G
E-------
E
D
N
F
W
Q
M
G
-
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
-------------
E
G
D
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
--
R
D
E
-------
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
---------------------
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
K
Y
G
E
K
F
-----------------------------------------------
E
T
-
D
V
A
--------------------------
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
F
Q
C
E
L
E
E
Q
R
E
R
-
A
R
K
H
---------P
V
Y
S
H
L
K
E
L
G
K
T
S
A
F
V
G
A
A
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
84.76
29%
-57
- C2 -
2ZTG
3
SYA_ARCFU
A:
[58-739]
-
K
P
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
G
V
A
P
P
P
--
A
N
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
E
---
L
G
V
K
K
E
D
I
V
-----------------------------
Y
----------
K
--------
E
-
E
P
W
A
G
G
---
G
N
A
G
P
C
L
E
A
I
V
-----------------------
G
G
L
E
V
A
T
L
V
F
M
N
L
E
--
E
H
P
-------
E
G
DIEIKG
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
---------------------
V
Y
D
A
-
I
F
P
E
V
V
D
T
I
I
D
N
S
N
V
S
F
N
R
E
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
GIMGELRGERL
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
P
-
L
E
K
--------------------------
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
E
E
L
E
L
G
L
-
D
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
E
F
D
V
---
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
R
L
V
E
R
-----
K
K
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
K-
D
I
Y
A
E
L
A
K
R
H
S
K
-
A
E
K
V
Q
E
K
K
--
I
------
T
L
Q
N
E
Y
P
A
T
E
K
L
Y
Y
D
D
P
TLL
E
F
E
A
E
V
I
G
V
E
------------
G
D
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
--
G
K
F
E
V
V
D
V
L
E
-
A
D
G
V
V
L
H
V
V
K
G
-
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
R
L
Y
Q
--
G
G
V
P
P
G
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.44
46%
-66
- C2 -
1YFR
3
SYA_AQUAE
A:
[3-426]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
--
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
NEH
I
G
-
I
P
S
E
R
I
W
R
L
G
E
---------
E
--------
D
-
N
F
W
Q
M
G
D
V
-
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
-------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
--
R
D
E
-------
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
---------------------
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
K
Y
G
E
K
------------------------------------------------
F
E
T
D
V
A
--------------------------
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
F
Q
C
E
L
E
E
Q
R
E
R
-
A
R
K
H
P
V
Y
S
H
L
K
E
L
-
G
K
T
S
A
F
V
G
A
A
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
84.27
46%
-64
- C2 -
3HXZ
4
SYA_ECOLI
C:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E--
K
E
-
V
G
I
P
R
E
R
I
I
R
I
GDNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
----
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
RQ
A
D
G
T
----
M
------------
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
T
---
D
------------------------------------------------
L
S
-
N
K
S
--------------------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
-
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
84.14
46%
-63
- C2 -
3HXZ
4
SYA_ECOLI
D:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E--
K
E
-
V
G
I
P
R
E
R
I
I
R
I
GDNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
----
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
RQ
A
D
G
T
----
M
------------
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
T
---
D
------------------------------------------------
L
S
-
N
K
S
--------------------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
-
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.12
46%
-66
- C2 -
1YFT
1
SYA_AQUAE
A:
[3-426]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
--
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
EH
I
G
-
I
P
S
E
R
I
W
R
L
G
E
---------
E
--------
D
-
N
F
W
Q
M
G
D
V
-
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
-------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
--
R
D
E
-------
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
---------------------
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
K
Y
G
E
K
------------------------------------------------
F
E
T
D
V
A
--------------------------
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
F
Q
C
E
L
E
E
Q
R
E
R
-
A
R
K
H
P
V
Y
S
H
L
K
E
L
-
G
K
T
S
A
F
V
G
A
A
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.08
46%
-67
- C2 -
1YFS
1
SYA_AQUAE
A:
[3-426]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
--
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
EH
I
G
-
I
P
S
E
R
I
W
R
L
G
E
---------
E
--------
D
-
N
F
W
Q
M
G
D
V
-
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
-------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
--
R
D
E
-------
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
---------------------
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
K
Y
G
E
K
------------------------------------------------
F
E
T
D
V
A
--------------------------
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
F
Q
C
E
L
E
E
Q
R
E
R
-
A
R
K
H
P
V
Y
S
H
L
K
E
L
-
G
K
T
S
A
F
V
G
A
A
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
83.99
48%
-67
- C2 -
3HY0
4
SYA_ECOLI
A:
[2-439]
---
K
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
---
E
K
E
V
G
I
P
R
E
R
I
I
R
I
---------
G
DNKGAPYA
S
D
N
F
W
Q
M
G
-
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
----
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
--
R
Q
A
-------
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
T
D
---------------------------------------------------
L
S
-
N
K
S
--------------------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
-
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.98
46%
-58
- C2 -
3HY1
4
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
--
K
E
-
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
----
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
RQ
A
D
G
T
----
M
------------
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
T
---
D
------------------------------------------------
L
S
-
N
K
S
--------------------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
-
A
R
E
A
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.97
46%
-68
- C2 -
3HTZ
-
SYA_AQUAE
A:
[2-425]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
--
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
N
EH
I
G
-
I
P
S
E
R
I
W
R
L
G
E
---------
E
--------
D
-
N
F
W
Q
M
G
D
V
-
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
-------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
--
R
D
E
-------
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
---------------------
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
K
Y
G
E
K
------------------------------------------------
F
E
T
D
V
A
--------------------------
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
F
Q
C
E
L
E
E
Q
R
E
R
-
A
R
K
P
V
Y
S
H
L
K
E
L
G
-
K
T
S
A
F
V
G
A
A
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.93
46%
-63
- C2 -
3HXU
5
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
--
K
E
-
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
----
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
----
M
------------
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
T
---
D
------------------------------------------------
L
S
-
N
K
S
--------------------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
-
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
83.84
46%
-63
- C2 -
3HXZ
6
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
--
K
E
-
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
----
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
----
M
------------
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
T
---
D
------------------------------------------------
L
S
-
N
K
S
--------------------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
-
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
83.82
46%
-63
- C2 -
3HY0
4
SYA_ECOLI
B:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E--
K
E
-
V
G
I
P
R
E
R
I
I
R
I
GDNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
----
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
RQ
A
D
G
T
----
M
------------
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
T
---
D
------------------------------------------------
L
S
-
N
K
S
--------------------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
-
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
83.76
46%
-65
- C2 -
3HXY
5
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
--
K
E
-
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
----
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
RQ
A
D
G
T
----
M
------------
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
T
---
D
------------------------------------------------
L
S
-
N
K
S
--------------------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
-
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
83.67
46%
-62
- C2 -
3HXZ
6
SYA_ECOLI
B:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E--
K
E
-
V
G
I
P
R
E
R
I
I
R
I
GDNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
----
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
RQ
A
D
G
T
----
M
------------
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
T
---
D
------------------------------------------------
L
S
-
N
K
S
--------------------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
-
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
83.66
46%
-66
- C2 -
1YFS
1
SYA_AQUAE
B:
[3-426]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
--
Y
K
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
E
E
A
Y
R
I
W
NEH
I
G
-
I
P
S
E
R
I
W
R
L
G
E
---------
E
--------
D
-
N
F
W
Q
M
G
D
V
-
G
P
C
G
P
S
S
E
I
Y
V
D
R
G
E
E
Y
E
G
D
-------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
--
R
D
E
-------
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
---------------------
N
F
E
I
D
I
I
F
P
L
I
Q
F
G
E
E
V
S
G
K
K
Y
G
E
K
------------------------------------------------
F
E
T
D
V
A
--------------------------
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
Y
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
E
--
G
F
Q
C
E
L
E
E
Q
R
E
R
-
A
R
K
H
P
V
Y
S
H
L
K
E
L
-
G
K
T
S
A
F
V
G
A
A
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
83.65
46%
-63
- C2 -
3HXW
5
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
--
K
E
-
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
----
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
----
M
------------
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
T
---
D
------------------------------------------------
L
S
-
N
K
S
--------------------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
-
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
83.54
46%
-63
- C2 -
3HXX
3
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
--
K
E
-
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
----
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
----
M
------------
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
T
---
D
------------------------------------------------
L
S
-
N
K
S
--------------------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
-
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.53
46%
-64
- C2 -
3HXV
6
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
--
K
E
-
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
----
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
----
M
------------
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
T
---
D
------------------------------------------------
L
S
-
N
K
S
--------------------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
-
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
83.34
46%
-63
- C2 -
3HY0
4
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
--
Y
S
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
D
E
A
Y
E
I
W
E
--
K
E
-
V
G
I
P
R
E
R
I
I
R
I
G
DNKGAPYA
S
--------
D
-
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
G
D
H
I
W
G
G
P
P
G
----
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
T
----
M
------------
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
---------------------
N
Y
D
I
D
L
F
R
T
L
I
Q
A
V
A
K
V
T
G
A
T
---
D
------------------------------------------------
L
S
-
N
K
S
--------------------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
N
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
S
G
---
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
A
--
G
F
E
A
A
M
E
E
Q
R
R
R
-
A
R
E
A
S
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------