@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0858: (2015-12-03 )
MTYLAPVLTIAGTDPSGGAGIMADLKTFQARRTYGMAVVTSVVAQNTCGVRGVQHIETAIIDQQLACVYDDIKPKAVKTGMLAERETISLVASYLKKYPQPYVLDPVMVATSGHRLIDSDAVEALKEDLLPLATIITPNLPEAEILVGYDLSDEVSIIKAGYDIQKQYSVRNVLIKGGHLDGLAKDYLFLEKEGLITLSNQRINTIHTHGTGCTFAAVVAAELAKGQSILNAVSTAKSFITSAIETAPELGLGNGPVNHTSYQGD
Atome Classification :
(32 SA)
.........10........20........30........40....--..--..50........60........70........80........90..-...-..---.-100.......110.......120.......130.......140.....-..150--..-.......160.......170.......180--.....-..190.-......200.......210.......220.......230.......240......--.250.----..--......-260...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTY
L
A
P
V
L
T
I
AGTDPSGGA
G
I
M
A
D
L
K
T
F
Q
A
R
R
T
Y
G
M
A
V
V
T
S
V
V
A
Q--NT--CGVR
G
V
Q
H
I
E
T
A
I
I
D
Q
Q
L
A
C
V
YDDIK
P
K
A
V
K
TGMLA
E
R
E
T
I
S
L
V
A
S
-
Y
L
K
-KY---P-QPYVL
D
P
V
M
V
ATSGHRLI
D
S
D
A
V
E
A
L
K
E
D
L
L
P
L
A
T
IITPNLPEA
E
I
L
V
-GYD----LS-DE
V
S
I
I
KAGY
D
I
Q
K
Q
YSVR
N
V
L
I
KGGHL
D
G
--
L
A
K
D
Y
-
L
F
L
EKE-
G
L
I
T
LSN
Q
R
I
N
T
I
HTHGT
G
C
T
F
A
A
V
V
A
A
E
L
AK
G
Q
S
I
L
N
A
V
S
T
A
K
S
F
I
T
S
A
I
ETAP--EL--G----LG--NGPVNH-TSYQGD
22
PsiBlast_CBE
91.71
44%
-102
- C2 -
1JXI
3
THID_SALTY
B:
[29-283]
-------
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
--
C
G
V
Q
S
V
Y
R
I
E
P
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
-
R
L
Q
-
R
H
---
H
V
R
N
V
V
L
D
T
V
M
L
A
K
S
G
D
P
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
P
H
----
A
R
-
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
-
M
G
C
E
A
V
L
M
K
G
----------
D
W
-
L
F
-
T
R
E
-
G
E
Q
R
F
---
R
V
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
A
D
TL
E
V
--
G
----
K
G
--
I
G
P
V
H
H
-
F
H
A
W
W
-
81
HHSearch
90.98
43%
-94
- C2 -
1UB0
7
?
A:
[1-257]
---
M
R
V
A
L
T
I
A
G
S
D
S
G
G
G
A
G
V
Q
A
D
L
K
V
F
F
R
F
G
V
Y
G
T
S
A
L
T
L
V
T
A
Q
--
N
T
--
L
G
V
Q
R
V
H
L
L
P
P
E
V
V
Y
A
Q
I
E
S
V
A
Q
D
F
P
L
H
A
A
K
T
G
A
L
G
D
A
A
I
V
E
A
V
A
E
-
A
V
R
-
R
F
---
G
V
R
P
L
V
V
D
P
V
M
---------
A
K
E
A
A
A
A
L
K
E
R
L
F
P
L
A
D
L
V
T
P
N
R
L
E
A
E
A
L
L
-
G
R
P
----
I
R
-
T
L
K
E
A
E
E
A
A
K
A
L
L
A
-
L
G
P
K
A
V
L
L
K
G
G
H
L
----
E
A
V
D
L
-
L
A
T
R
G
--
G
V
L
R
F
S
A
P
R
V
H
T
R
N
T
H
G
T
G
C
T
L
S
A
A
I
A
A
L
L
A
K
G
R
P
L
A
E
A
V
A
E
A
K
A
Y
L
T
R
A
L
K
T
A
P
--
S
L
--
G
----
H
G
--
H
G
P
L
D
H
-
W
A
----
3
PsiBlast_PDB
90.98
44%
-100
- C2 -
1JXI
3
THID_SALTY
A:
[29-283]
-------
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
--
C
G
V
Q
S
V
Y
R
I
E
P
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
-
R
L
Q
-
R
H
---
H
V
R
N
V
V
L
D
T
V
M
L
A
K
S
G
D
P
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
P
H
----
A
R
-
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
-
M
G
C
E
A
V
L
M
K
G
----------
D
W
-
L
F
-
T
R
E
-
G
E
Q
R
F
---
R
V
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
A
D
TL
E
V
--
G
----
K
G
--
I
G
P
V
H
H
-
F
H
A
W
W
-
2
PsiBlast_PDB
90.71
44%
-106
- C2 -
1JXH
2
THID_SALTY
A:
[29-283]
-------
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
--
C
G
V
Q
S
V
Y
R
I
E
P
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
-
R
L
Q
-
R
H
---
H
V
R
N
V
V
L
D
T
V
M
L
------
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
P
H
----
A
R
-
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
-
M
G
C
E
A
V
L
M
K
G
----------
D
W
-
L
F
-
T
R
E
-
G
E
Q
R
F
---
R
V
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
A
D
T
L
E
V
--
G
----
K
G
--
I
G
P
V
H
H
-
F
H
A
W
W
-
23
PsiBlast_CBE
90.65
44%
-106
- C2 -
1JXH
2
THID_SALTY
B:
[29-283]
-------
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
--
C
G
V
Q
S
V
Y
R
I
E
P
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
-
R
L
Q
-
R
H
---
H
V
R
N
V
V
L
D
T
V
M
L
------
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
P
H
----
A
R
-
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
-
M
G
C
E
A
V
L
M
K
G
----------
D
W
-
L
F
-
T
R
E
-
G
E
Q
R
F
---
R
V
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
A
D
TL
E
V
--
G
----
K
G
--
I
G
P
V
H
H
-
F
H
A
W
W
-
80
HHSearch
89.04
43%
-104
- C2 -
1JXH
2
THID_SALTY
A:
[23-288]
-
M
Q
R
I
N
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
--
C
G
V
Q
S
V
Y
R
I
E
P
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
-
R
L
Q
-
R
H
---
H
V
R
N
V
V
L
D
T
V
M
L
------
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
-
D
A
P
----
H
A
R
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
-
M
G
C
E
A
V
L
M
K
G
----
D
------
W
-
L
F
T
R
E
--
G
E
Q
R
F
---
R
V
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
A
D
--
T
L
E
V
G
----
K
G
--
I
G
P
V
H
H
F
H
A
W
W
--
21
PsiBlast_CBE
87.80
46%
-104
- C2 -
4JJP
1
?
B:
[9-246]
----
I
P
T
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
I
G
T
Y
G
M
S
V
I
T
A
I
T
A
Q
--
N
T
--
K
G
V
F
A
V
E
D
L
N
K
K
I
I
K
K
Q
I
E
A
V
F
E
D
I
P
P
R
A
V
K
I
G
M
V
S
S
P
E
I
I
L
E
I
V
E
-
N
L
K
-
K
Y
N--
P
-
K
Y
L
V
V
D
P
V
M
I
-----
Y
L
L
K
P
E
A
K
E
N
L
I
K
Y
L
I
P
L
A
Y
I
I
T
P
N
I
P
E
A
E
E
I
T
-
G
I
K
----
I
H
-
N
V
D
D
M
K
R
V
G
E
E
I
L
-
Q
L
G
P
K
F
V
L
M
K
G
G
-------
A
V
D
I
-
L
-
V
G
K
N
-
I
F
K
V
Y
K
S
-----------
G
C
T
L
S
S
A
I
T
S
Y
L
A
L
G
Y
E
I
T
E
A
V
N
L
S
K
I
Y
I
T
E
A
---------------------------------
4
PsiBlast_PDB
87.58
41%
-85
- C2 -
2I5B
1
PDXK_BACSU
A:
[7-266]
-------
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
D
P
N
N
--
S
W
N
H
Q
V
F
P
I
D
T
D
T
I
R
A
Q
L
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
-
T
I
K
E
K
Q
---
L
-
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
-
G
M
D
ELKT
V
D
-
D
M
I
E
A
A
K
K
I
H
A
L
G
A
Q
Y
V
V
---
I
T
G
G
G
K
L
K
H
--
E
K
A
V
D
-
V
L
Y
D
G
E
-
T
A
E
V
L
E
S
E
M
I
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
K
E
S
F
--
P
L
--
N
----
Q
Y
--
V
G
P
T
K
H
-
S
A
L
R
L
N
83
HHSearch
87.41
42%
-84
- C2 -
2I5B
1
PDXK_BACSU
A:
[3-266]
---
M
H
K
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
--
D
P
NN
S
W
N
H
Q
V
F
P
I
D
T
D
T
I
R
A
Q
L
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
-
T
I
K
-
E
K
---
Q
L
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
-
G
M
D
----
E
L
K
T
V
D
D
M
I
E
A
A
K
K
I
H
A
-
L
G
A
Q
Y
V
V
I
T
G
G
G
K
L
K
HE
K
A
V
D
V
-
L
Y
D
G
E
--
T
A
E
V
L
E
S
E
M
I
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
K
E
S
F
--
P
L
--
N
----
Q
Y
--
V
G
P
T
K
H
-
S
A
L
R
L
N
25
PsiBlast_CBE
86.98
41%
-85
- C2 -
2I5B
1
PDXK_BACSU
D:
[7-266]
-------
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
DP
N
N
--
S
W
N
H
Q
V
F
P
I
D
T
D
T
I
R
A
Q
L
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
-
T
I
K
E
K
Q
---
L
-
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
-
G
M
D
ELKT
V
D
-
D
M
I
E
A
A
K
K
I
H
A
L
G
A
Q
Y
V
V
---
I
T
G
G
G
K
L
K
H
--
E
K
A
V
D
-
V
L
Y
D
G
E
-
T
A
E
V
L
E
S
E
M
I
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
K
E
S
F
--
P
L
--
N
----
Q
Y
--
V
G
P
T
K
H
-
S
A
L
R
L
N
26
PsiBlast_CBE
86.87
41%
-83
- C2 -
2I5B
1
PDXK_BACSU
C:
[7-266]
-------
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
D
P
N
N
--
S
W
N
H
Q
V
F
P
I
D
T
D
T
I
R
A
Q
L
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
-
T
I
K
E
K
Q
---
L
-
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
-
G
M
D
ELKT
V
D
-
D
M
I
E
A
A
K
K
I
H
A
L
G
A
Q
Y
V
V
---
I
T
G
G
G
K
L
K
H
--
E
K
A
V
D
-
V
L
Y
D
G
E
-
T
A
E
V
L
E
S
E
M
I
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
K
E
S
F
--
P
L
--
N
----
Q
Y
--
V
G
P
T
K
H
-
S
A
L
R
L
-
1
PsiBlast_PDB
86.65
46%
-100
- C2 -
4JJP
-
?
A:
[8-248]
---
K
I
P
T
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
I
G
T
Y
G
M
S
V
I
T
A
I
T
A
Q
--
N
T
--
K
G
V
F
A
V
E
D
L
N
K
K
I
I
K
K
Q
I
E
A
V
F
E
D
I
P
P
R
A
V
K
I
G
M
V
S
S
P
E
I
I
L
E
I
V
E
-
N
L
K
-
K
Y
N--
P
-
K
Y
L
V
V
D
P
V
M
I
S
K
S
G
Y
Y
L
L
K
P
E
A
K
E
N
L
I
K
Y
L
I
P
L
A
Y
I
I
T
P
N
I
P
E
A
E
E
I
T
-
G
I
K
----
I
H
-
N
V
D
D
M
K
R
V
G
E
E
I
L
-
Q
L
G
P
K
F
V
L
M
K
G
G
H
L
D
G
--
E
A
V
D
I
-
L
-
V
G
K
N
-
I
F
K
V
Y
K
S
E
----------
G
C
T
L
S
S
A
I
T
S
Y
L
A
L
G
Y
E
I
T
E
A
V
N
L
S
K
I
Y
I
T
E
A
I
K
-------------------------------
24
PsiBlast_CBE
86.38
41%
-84
- C2 -
2I5B
1
PDXK_BACSU
E:
[7-266]
-------
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
DP
N
N
--
S
W
N
H
Q
V
F
P
I
D
T
D
T
I
R
A
Q
L
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
-
T
I
K
E
K
Q
---
L
-
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
-
G
M
D
ELKT
V
D
-
D
M
I
E
A
A
K
K
I
H
A
L
G
A
Q
Y
V
V
---
I
T
G
G
G
K
L
K
H
--
E
K
A
V
D
-
V
L
Y
D
G
E
-
T
A
E
V
L
E
S
E
M
I
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
K
E
S
F
--
P
L
--
N
----
Q
Y
--
V
G
P
T
K
H
-
S
A
L
R
L
N
27
PsiBlast_CBE
86.24
41%
-81
- C2 -
2I5B
1
PDXK_BACSU
B:
[7-266]
-------
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
D
P
N
N
--
S
W
N
H
Q
V
F
P
I
D
T
D
T
I
R
A
Q
L
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
-
T
I
K
E
K
Q
---
L
-
K
N
V
V
I
D
P
V
M
---------
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
-
G
M
D
ELKT
V
D
-
D
M
I
E
A
A
K
K
I
H
A
L
G
A
Q
Y
V
V
---
I
T
G
G
G
K
L
K
H
--
E
K
A
V
D
-
V
L
Y
D
G
E
-
T
A
E
V
L
E
S
E
M
I
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
K
E
S
F
--
P
L
--
N
----
Q
Y
--
V
G
P
T
K
H
-
S
A
L
R
L
N
82
HHSearch
85.52
38%
-93
- C2 -
3RM5
2
THI20_YEAST
A:
[20-295]
-
E
K
L
P
T
V
L
S
I
A
G
T
D
P
S
G
G
A
G
I
E
A
D
V
K
T
I
T
A
H
R
C
Y
A
M
T
C
I
T
A
L
N
A
Q
--
T
P
--
V
K
V
Y
S
I
N
N
T
P
K
E
V
V
F
Q
T
L
E
S
N
L
K
D
M
K
C
N
V
I
K
T
G
M
L
T
A
-
A
A
I
E
V
L
H
E
-
K
L
L
-
Q
L
GEN
R
-
P
K
L
V
V
D
P
V
L
---------
G
K
D
I
V
S
L
I
T
E
K
V
A
P
F
A
D
I
L
T
P
N
I
P
E
C
Y
K
L
L
-
G
E
E
R
K
--
V
N
-
G
L
Q
D
I
F
Q
I
A
K
D
L
A
K
I
T
K
C
S
N
I
L
V
K
G
G
H
---E
K
Y
I
T
D
V
-
L
F
L
G
A
E
Q
K
F
I
I
F
K
G
N
F
V
N
T
T
H
T
H
G
T
G
C
T
L
A
S
A
I
A
S
N
L
A
R
G
Y
S
L
P
Q
S
V
Y
G
G
I
E
Y
V
Q
N
A
V
A
I
G
C
--
D
V
--
T
KETV
K
D
--
N
G
P
I
N
H
-
V
Y
A
V
E
I
37
PsiBlast_CBE
84.11
37%
-79
- C2 -
4C5K
4
?
C:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
------
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
70
Fugue
83.84
41%
-86
- C2 -
1JXH
2
THID_SALTY
A:
[23-288]
M
Q
R
-
I
N
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
--
C
G
V
Q
S
V
Y
R
I
E
P
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
-
R
L
Q
-
R
H
---
H
V
R
N
V
V
L
D
T
V
M
L
------
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
-
D
A
P
----
H
A
-
R
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
M
G
C
E
A
V
L
M
K
G
D
W
L
F
T
--
R
E
G
--------------
E
Q
R
F
R
V
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
A
D
--
T
L
--
E
----
V
G
K
G
I
G
P
V
H
H
-
F
H
A
W
W
-
7
PsiBlast_PDB
83.31
37%
-80
- C2 -
4C5L
3
?
A:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
----
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
--------
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
--
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
29
PsiBlast_CBE
83.22
37%
-78
- C2 -
4C5N
4
?
C:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
---------
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
5
PsiBlast_PDB
83.19
37%
-77
- C2 -
4C5J
3
?
A:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
28
PsiBlast_CBE
83.02
37%
-78
- C2 -
4C5N
5
?
D:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
V
C
-------
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
33
PsiBlast_CBE
82.96
37%
-80
- C2 -
4C5M
5
?
B:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
38
PsiBlast_CBE
82.93
37%
-80
- C2 -
4C5K
4
?
B:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
V
C
K
--
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
6
PsiBlast_PDB
82.29
37%
-80
- C2 -
4C5K
4
?
A:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
V
C
K
--
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
30
PsiBlast_CBE
82.18
37%
-78
- C2 -
4C5N
4
?
B:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
V
-------
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
34
PsiBlast_CBE
82.10
37%
-76
- C2 -
4C5L
2
?
D:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
V
C
K
G
-----
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
--
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
32
PsiBlast_CBE
82.00
37%
-80
- C2 -
4C5M
5
?
C:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
V
C
---
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
36
PsiBlast_CBE
81.91
37%
-78
- C2 -
4C5K
5
?
D:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
8
PsiBlast_PDB
81.84
37%
-77
- C2 -
4C5M
5
?
A:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
V
C
K
---
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
9
PsiBlast_PDB
80.86
37%
-80
- C2 -
4C5N
2
?
A:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
--------
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
35
PsiBlast_CBE
80.78
37%
-73
- C2 -
4C5L
1
?
C:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
V
C
K
G
-----
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
--
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I
31
PsiBlast_CBE
80.36
37%
-77
- C2 -
4C5M
6
?
D:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D-
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
-
S
N
---
A
-
Q
Y
F
V
V
D
P
V
M
V
C
K
---
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
-
G
L
G
----
K
L
-
N
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
G
A
Q
H
V
I
I
K
G
G
K
A
L
D
--
Q
D
K
S
Y
D
L
Y
Y
D
G
Q
-
T
F
Y
Q
L
T
T
D
M
F
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
K
N
G
W
--
K
M
--
N
----
D
F
--
V
G
P
V
D
H
-
G
A
Y
N
R
I