@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0879: (2015-12-04 )
MAINAQEISALIKKQIEDFQPNFDVTETGIVTYIGDGIARARGLDNAMSGELLEFSNGAYGMAQNLESNDVGIIILGDFSEIREGDVVKRTGKIMEVPVGEAMIGRVVNPLGQPVDGLGEIETTATRPVETPAPGVMQRKSVFEPLQTGLKAIDALVPIGRGQRELIIGDRQTGKTSVAIDAILNQKGQDMICIYVAIGQKESTVRTQVETLRKYGALDYTIVVTASASQPSPLLFIAPYAGVAMAEEFMYNGKHVLIVYDDLSKQAVAYRELSLLLRRPPGREAYPGDVFYLHSRLLERSAKLSDALGGGSITALPFIETQAGDISAYIATNVISITDGQIFLQENLFNSGIRPAIDAGSSVSRVGGAAQIKAMKRVAGTLRLDLASYRELEAFTQFGSDLDAATQAKLNRGRRTVEVLKQPLHKPLPVEKQVVILYALTHGFLDDVPVNDILAFEEALYDYFDAHYDNLFETIRTTKDLPEEAELDAAIQAFKDQSQFK
Atome Classification :
(20 SA)
.........10........20........30........40........50....-.-...60........70........80........90........100.......110.......120.-......130.......140.......150.......160.......170.......180.....----..190--.........200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.--.--..--...490.......500
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAI
N
A
Q
E
I
S
A
L
I
K
K
Q
I
E
D
FQPNFDVTET
G
I
V
T
YIG
D
G
I
A
R
ARGLDNAMSGE
L
L
EF-S-NGAYGMAQNLESN
D
V
G
I
I
I
LG
D
F
S
E
IREG
D
V
V
KRTG
K
I
M
EVPV
G
E
A
M
I
G
R
V
V
N
PLGQPVDGLGEIET-TATRPVETPA
P
G
V
M
Q
R
K
S
V
F
E
P
L
Q
T
G
L
K
A
I
D
A
LVPIGRG
Q
R
E
L
I
I
GDRQTGKT
S
V
A
I
D
A
I
LNQK----GQ
D
----
M
I
C
I
Y
V
A
IGQKE
S
T
V
R
T
Q
V
E
T
L
R
KYGA
L
D
Y
T
I
V
V
T
ASASQPS
P
L
L
F
IAPYA
G
V
A
M
A
E
E
F
MYNG
K
H
V
L
I
V
YDDL
S
K
Q
A
V
A
Y
R
E
L
S
L
L
LRRPPGREAYPG
D
V
F
Y
L
H
S
R
L
L
E
R
S
A
K
L
S
DALGGG
S
I
T
A
L
P
F
I
ETQAGD
I
S
A
Y
I
A
T
N
V
I
S
ITD
G
Q
I
F
L
Q
E
N
L
F
NSGIRPAIDAGSS
V
S
RVG
G
A
A
Q
I
K
A
M
K
R
V
A
G
T
L
R
L
D
L
A
S
Y
R
E
L
E
A
F
T
QFGSDL
D
A
A
T
Q
A
K
L
NRGR
R
T
V
E
V
L
K
QPLHKPLPVE
K
Q
V
V
I
L
Y
A
L
T
H
GFLDDVP
V
N
D
I
L
A
F
E
E
A
L
Y
D
Y
F
D
A
H
Y
D
N
L
F
E
T
I
R
T
TKDLP
E
--
E
--
A
E
--
L
D
A
A
I
Q
A
F
K
DQSQFK-
149
Fugue
95.41
74%
-94
- C6 -
1SKY
1
ATPA_BACP3
B:
[21-502]
--------------------
S
Q
I
Q
V
S
D
V
G
T
V
I
Q
V
G
D
G
I
A
R
A
H
G
L
D
N
V
M
S
G
E
A
V
E
F
-
A
-
N
A
V
M
G
M
A
L
N
L
E
E
N
N
V
G
I
V
I
L
G
P
Y
T
G
I
K
E
G
D
E
V
R
R
T
G
R
I
M
E
V
P
V
G
E
T
L
I
G
R
V
V
N
P
L
G
Q
P
V
D
G
L
G
P
V
E
T
T-
E
T
R
P
I
E
S
R
A
P
G
V
M
D
R
R
S
V
H
E
P
L
Q
T
G
I
K
A
I
D
A
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
V
A
I
D
T
I
I
N
Q
K
DQ----
N
----
M
I
C
I
Y
V
A
I
G
Q
K
E
S
T
V
A
T
V
V
E
T
L
A
K
H
G
A
P
D
Y
T
I
V
V
T
A
S
A
S
Q
P
A
P
L
L
F
L
A
P
Y
A
G
V
A
M
G
E
Y
F
M
I
M
G
K
H
V
L
V
V
I
D
D
L
S
K
Q
A
A
A
Y
R
Q
L
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
I
F
Y
L
H
S
R
L
L
E
R
A
A
K
L
S
D
A
K
G
G
G
S
L
T
A
L
P
F
V
E
T
Q
A
G
D
I
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
Q
S
D
L
F
F
S
G
V
R
P
A
I
N
A
G
L
S
V
S
R
V
G
G
A
A
Q
I
K
A
M
K
K
V
A
G
T
L
R
L
D
L
A
A
Y
R
E
L
E
F
A
Q
F
S
D
---
D
K
A
T
Q
A
N
V
A
R
G
A
R
T
V
E
V
L
K
Q
D
L
H
Q
P
I
P
V
E
K
Q
V
L
I
I
Y
A
L
T
R
G
F
L
D
D
I
P
V
E
D
V
R
R
F
E
K
E
F
Y
L
W
L
D
Q
N
G
Q
H
L
L
E
H
I
R
T
T
K
D
L
P
N
--
E
--
D
D
--
L
N
Q
A
I
E
A
F
K
K
T
F
V
V
S
Q
128
HHSearch
92.53
72%
-94
- C6 -
2QE7
-
?
A:
[27-500]
--------------------------
E
V
G
T
V
I
Q
V
G
D
G
I
A
R
V
H
G
L
E
K
V
M
A
G
E
L
L
E
F
-
E
-
N
G
V
M
G
M
A
Q
N
L
E
E
D
N
V
G
V
V
I
L
G
P
Y
T
E
I
R
E
G
T
Q
V
K
R
T
G
R
I
M
E
V
P
V
G
E
A
L
L
G
R
V
V
N
P
L
G
Q
P
L
D
G
R
G
P
I
E
T
-
A
E
Y
R
P
I
E
S
P
A
P
G
V
M
D
R
K
S
V
H
E
P
L
Q
T
G
I
K
A
I
D
S
M
I
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
T
I
A
I
D
T
I
I
N
Q
K
----
G
Q
D
----
V
I
C
I
Y
V
A
I
G
Q
K
Q
S
T
V
A
G
V
V
E
T
L
R
Q
H
D
A
L
D
Y
T
I
V
V
T
A
S
A
S
E
P
A
P
L
L
Y
L
A
P
Y
A
G
C
A
M
G
E
Y
F
M
Y
K
G
K
H
A
L
V
V
Y
D
D
L
S
K
Q
A
A
A
Y
R
E
L
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
L
S
D
E
K
G
G
G
S
L
T
A
L
P
F
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
S
D
L
F
Y
S
G
V
R
P
A
V
N
V
G
I
S
V
S
R
V
G
G
A
A
Q
I
K
A
M
K
K
V
A
G
T
L
R
L
D
L
A
Q
Y
R
E
L
Q
A
F
A
Q
F
G
S
D
L
D
K
A
T
Q
A
K
L
N
R
G
E
R
T
V
E
I
L
K
Q
D
E
H
K
P
M
P
V
E
E
Q
V
I
S
I
Y
A
V
T
N
G
F
M
D
D
I
P
V
E
D
V
R
R
F
E
E
E
L
L
S
F
M
R
A
N
K
D
S
L
L
D
H
I
R
Q
T
G
E
L
P
D
--
T
--
K
E
--
L
D
A
A
I
E
E
F
K
K
G
F
T
P
--
2
PsiBlast_PDB
92.50
73%
-95
- C6 -
2QE7
-
?
A:
[27-495]
--------------------------
E
V
G
T
V
I
Q
V
G
D
G
I
A
R
V
H
G
L
E
K
V
M
A
G
E
L
L
E
F
-
E
-
N
G
V
M
G
M
A
Q
N
L
E
E
D
N
V
G
V
V
I
L
G
P
Y
T
E
I
R
E
G
T
Q
V
K
R
T
G
R
I
M
E
V
P
V
G
E
A
L
L
G
R
V
V
N
P
L
G
Q
P
L
D
G
R
G
P
I
E
T
-
A
E
Y
R
P
I
E
S
P
A
P
G
V
M
D
R
K
S
V
H
E
P
L
Q
T
G
I
K
A
I
D
S
M
I
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
T
I
A
I
D
T
I
I
N
Q
K
----
G
Q
D
----
V
I
C
I
Y
V
A
I
G
Q
K
Q
S
T
V
A
G
V
V
E
T
L
R
Q
H
D
A
L
D
Y
T
I
V
V
T
A
S
A
S
E
P
A
P
L
L
Y
L
A
P
Y
A
G
C
A
M
G
E
Y
F
M
Y
K
G
K
H
A
L
V
V
Y
D
D
L
S
K
Q
A
A
A
Y
R
E
L
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
L
S
D
E
K
G
G
G
S
L
T
A
L
P
F
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
S
D
L
F
Y
S
G
V
R
P
A
V
N
V
G
I
S
V
S
R
V
G
G
A
A
Q
I
K
A
M
K
K
V
A
G
T
L
R
L
D
L
A
Q
Y
R
E
L
Q
A
F
A
Q
F
G
S
D
L
D
K
A
T
Q
A
K
L
N
R
G
E
R
T
V
E
I
L
K
Q
D
E
H
K
P
M
P
V
E
E
Q
V
I
S
I
Y
A
V
T
N
G
F
M
D
D
I
P
V
E
D
V
R
R
F
E
E
E
L
L
S
F
M
R
A
N
K
D
S
L
L
D
H
I
R
Q
T
G
E
L
P
D
--
T
--
K
E
--
L
D
A
A
I
E
E
F
K
K
G
F
T
P
--
104
PsiBlast_CBE
91.81
56%
-97
- C6 -
3ZIA
2
ATPA_YEAST
C:
[26-506]
-----------------------
N
L
N
E
T
G
R
V
L
A
V
G
D
G
I
A
R
V
F
G
L
N
N
I
Q
A
E
E
L
V
E
F
-
S
-
S
G
V
K
G
M
A
L
N
L
E
P
G
Q
V
G
I
V
L
F
G
S
D
R
L
V
K
E
G
E
L
V
K
R
T
G
N
I
V
D
V
P
V
G
P
G
L
L
G
R
V
V
D
A
L
G
N
P
I
D
G
K
G
P
I
D
A
-
A
G
R
S
R
A
Q
V
K
A
P
G
I
L
P
R
R
S
V
H
E
P
V
Q
T
G
L
K
A
V
D
A
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
A
V
A
L
D
T
I
L
N
Q
K
RWNN
G
S
D
ESKK
L
Y
C
V
Y
V
A
V
G
Q
K
R
S
T
V
A
Q
L
V
Q
T
L
E
Q
H
D
A
M
K
Y
S
I
I
V
A
A
T
A
S
E
A
A
P
L
Q
Y
L
A
P
F
T
A
A
S
I
G
E
W
F
R
D
N
G
K
H
A
L
I
V
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
L
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
L
S
E
K
E
G
S
G
S
L
T
A
L
P
V
I
E
T
Q
G
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
A
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
V
K
A
L
K
Q
V
A
G
S
L
K
L
F
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
S
T
K
Q
T
L
V
R
G
E
R
L
T
Q
L
L
K
Q
N
Q
Y
S
P
L
A
T
E
E
Q
V
P
L
I
Y
A
G
V
N
G
H
L
D
G
I
E
L
S
R
I
G
E
F
E
S
S
F
L
S
Y
L
K
S
N
H
N
E
L
L
T
E
I
R
E
K
G
E
L
S
K
--
E
LL
A
S
--
L
K
S
A
T
E
S
F
V
A
T
-----
129
HHSearch
91.10
59%
-99
- C6 -
2R9V
4
ATPA_THEMA
A:
[29-514]
----------------
K
S
F
E
E
K
I
D
L
E
D
T
G
K
V
I
Q
V
G
D
G
I
A
R
A
Y
G
L
N
K
V
M
V
S
E
L
V
E
F
-
V
E
T
G
V
K
G
V
A
F
N
L
E
E
D
N
V
G
I
I
I
L
G
E
Y
K
D
I
K
E
G
H
T
V
R
R
L
K
R
I
I
E
V
P
V
G
E
E
L
L
G
R
V
V
N
P
L
G
E
P
L
D
G
K
G
P
I
N
A
-
K
N
F
R
P
I
E
I
K
A
P
G
V
I
Y
R
K
P
V
D
T
P
L
Q
T
G
I
K
A
I
D
S
M
I
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
A
I
A
I
D
T
I
I
N
Q
K
----
G
Q
G
----
V
Y
C
I
Y
V
A
I
G
Q
K
K
S
A
I
A
R
I
I
D
K
L
R
Q
Y
G
A
M
E
Y
T
T
V
V
V
A
S
A
S
D
P
A
S
L
Q
Y
I
A
P
Y
A
G
C
A
M
G
E
Y
F
A
Y
S
G
R
D
A
L
V
V
Y
D
D
L
S
K
H
A
V
A
Y
R
Q
L
S
L
L
M
R
R
P
P
G
R
E
A
Y
P
G
D
I
F
Y
L
H
S
R
L
L
E
R
A
V
R
L
N
D
K
L
G
G
G
S
L
T
A
L
P
I
V
E
T
Q
A
N
D
I
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
Y
L
E
P
G
L
F
Y
A
G
Q
R
P
A
I
N
V
G
L
S
V
S
R
V
G
G
S
A
Q
I
K
A
M
K
Q
V
A
G
M
L
R
I
D
L
A
Q
Y
R
E
L
E
T
F
A
Q
F
A
T
E
L
D
P
A
T
R
A
Q
I
I
R
G
Q
R
L
M
E
L
L
K
Q
E
Q
Y
S
P
M
P
V
E
E
Q
V
V
V
L
F
A
G
V
R
G
Y
L
D
D
L
P
V
E
E
V
R
R
F
E
K
E
F
L
R
F
M
H
E
K
H
Q
D
I
L
D
D
I
K
T
K
K
E
L
T
S
E
T
E
--
E
K
--
L
K
K
A
I
E
E
F
K
T
T
F
R
V
--
117
PsiBlast_CBE
91.03
56%
-98
- C6 -
3OE7
32
ATPA_YEAST
J:
[26-506]
-----------------------
N
L
N
E
T
G
R
V
L
A
V
G
D
G
I
A
R
V
F
G
L
N
N
I
Q
A
E
E
L
V
E
F
-
S
-
S
G
V
K
G
M
A
L
N
L
E
P
G
Q
V
G
I
V
L
F
G
S
D
R
L
V
K
E
G
E
L
V
K
R
T
G
N
I
V
D
V
P
V
G
P
G
L
L
G
R
V
V
D
A
L
G
N
P
I
D
G
K
G
P
I
D
A
-
A
G
R
S
R
A
Q
V
K
A
P
G
I
L
P
R
R
S
V
H
E
P
V
Q
T
G
L
K
A
V
D
A
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
A
V
A
L
D
T
I
L
N
Q
K
RWNN
G
S
D
ESKK
L
Y
C
V
Y
V
A
V
G
Q
K
R
S
T
V
A
Q
L
V
Q
T
L
E
Q
H
D
A
M
K
Y
S
I
I
V
A
A
T
A
S
E
A
A
P
L
Q
Y
L
A
P
F
T
A
A
S
I
G
E
W
F
R
D
N
G
K
H
A
L
I
V
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
L
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
L
S
E
K
E
G
S
G
S
L
T
A
L
P
V
I
E
T
Q
G
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
A
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
V
K
A
L
K
Q
V
A
G
S
L
K
L
F
L
A
Q
Y
R
E
V
A
A
F
A
---
S
D
L
D
A
S
T
K
Q
T
L
V
R
G
E
R
L
T
Q
L
L
K
Q
N
Q
Y
S
P
L
A
T
E
E
Q
V
P
L
I
Y
A
G
V
N
G
H
L
D
G
I
E
L
S
R
I
G
E
F
E
S
S
F
L
S
Y
L
K
S
N
H
N
E
L
L
T
E
I
R
E
K
G
E
L
S
K
--
E
LL
A
S
--
L
K
S
A
T
E
S
F
V
A
T
-----
125
PsiBlast_CBE
90.64
56%
-94
- C6 -
2WPD
3
ATPA_YEAST
C:
[26-506]
-----------------------
N
L
N
E
T
G
R
V
L
A
V
G
D
G
I
A
R
V
F
G
L
N
N
I
Q
A
E
E
L
V
E
F
-
S
-
S
G
V
K
G
M
A
L
N
L
E
P
G
Q
V
G
I
V
L
F
G
S
D
R
L
V
K
E
G
E
L
V
K
R
T
G
N
I
V
D
V
P
V
G
P
G
L
L
G
R
V
V
D
A
L
G
N
P
I
D
G
K
G
P
I
D
A
-
A
G
R
S
R
A
Q
V
K
A
P
G
I
L
P
R
R
S
V
H
E
P
V
Q
T
G
L
K
A
V
D
A
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
A
V
A
L
D
T
I
L
N
Q
K
RWNN
G
S
D
ESKK
L
Y
C
V
Y
V
A
V
G
Q
K
R
S
T
V
A
Q
L
V
Q
T
L
E
Q
H
D
A
M
K
Y
S
I
I
V
A
A
T
A
S
E
A
A
P
L
Q
Y
L
A
P
F
T
A
A
S
I
G
E
W
F
R
D
N
G
K
H
A
L
I
V
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
L
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
L
S
E
K
E
G
S
G
S
L
T
A
L
P
V
I
E
T
Q
G
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
A
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
V
K
A
L
K
Q
V
A
G
S
L
K
L
F
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
S
T
K
Q
T
L
V
R
G
E
R
L
T
Q
L
L
K
Q
N
Q
Y
S
P
L
A
T
E
E
Q
V
P
L
I
Y
A
G
V
N
G
H
L
D
G
I
E
L
S
R
I
G
E
F
E
S
S
F
L
S
Y
L
K
S
N
H
N
E
L
L
T
E
I
R
E
K
G
E
L
S
K
--
E
LL
A
S
--
L
K
S
A
T
E
S
F
V
A
T
F
----
100
PsiBlast_CBE
90.49
56%
-99
- C6 -
3ZRY
3
ATPA_YEAST
C:
[26-506]
-----------------------
N
L
N
E
T
G
R
V
L
A
V
G
D
G
I
A
R
V
F
G
L
N
N
I
Q
A
E
E
L
V
E
F
-
S
-
S
G
V
K
G
M
A
L
N
L
E
P
G
Q
V
G
I
V
L
F
G
S
D
R
L
V
K
E
G
E
L
V
K
R
T
G
N
I
V
D
V
P
V
G
P
G
L
L
G
R
V
V
D
A
L
G
N
P
I
D
G
K
G
P
I
D
A
-
A
G
R
S
R
A
Q
V
K
A
P
G
I
L
P
R
R
S
V
H
E
P
V
Q
T
G
L
K
A
V
D
A
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
A
V
A
L
D
T
I
L
N
Q
K
RWNN
G
S
D
ESK
K
L
Y
C
V
Y
V
A
V
G
Q
K
R
S
T
V
A
Q
L
V
Q
T
L
E
Q
H
D
A
M
K
Y
S
I
I
V
A
A
T
A
S
E
A
A
P
L
Q
Y
L
A
P
F
T
A
A
S
I
G
E
W
F
R
D
N
G
K
H
A
L
I
V
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
L
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
L
S
E
K
E
G
S
G
S
L
T
A
L
P
V
I
E
T
Q
G
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
A
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
V
K
A
L
K
Q
V
A
G
S
L
K
L
F
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
S
T
K
Q
T
L
V
R
G
E
R
L
T
Q
L
L
K
Q
N
Q
Y
S
P
L
A
T
E
E
Q
V
P
L
I
Y
A
G
V
N
G
H
L
D
G
I
E
L
S
R
I
G
E
F
E
S
S
F
L
S
Y
L
K
S
N
H
N
E
L
L
T
E
I
R
E
K
G
E
L
S
K
--
E
L
L
A
S
--
L
K
S
A
T
E
S
F
V
A
T
F
----
105
PsiBlast_CBE
90.44
56%
-98
- C6 -
3ZIA
2
ATPA_YEAST
B:
[25-506]
----------------------
A
N
L
N
E
T
G
R
V
L
A
V
G
D
G
I
A
R
V
F
G
L
N
N
I
Q
A
E
E
L
V
E
F
-
S
-
S
G
V
K
G
M
A
L
N
L
E
P
G
Q
V
G
I
V
L
F
G
S
D
R
L
V
K
E
G
E
L
V
K
R
T
G
N
I
V
D
V
P
V
G
P
G
L
L
G
R
V
V
D
A
L
G
N
P
I
D
G
K
G
P
I
D
A
-
A
G
R
S
R
A
Q
V
K
A
P
G
I
L
P
R
R
S
V
H
E
P
V
Q
T
G
L
K
A
V
D
A
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
A
V
A
L
D
T
I
L
N
Q
K
RWNN
G
S
D
ESK
K
L
Y
C
V
Y
V
A
V
G
Q
K
R
S
T
V
A
Q
L
V
Q
T
L
E
Q
H
D
A
M
K
Y
S
I
I
V
A
A
T
A
S
E
A
A
P
L
Q
Y
L
A
P
F
T
A
A
S
I
G
E
W
F
R
D
N
G
K
H
A
L
I
V
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
L
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
L
S
E
K
E
G
S
G
S
L
T
A
L
P
V
I
E
T
Q
G
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
A
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
V
K
A
L
K
Q
V
A
G
S
L
K
L
F
L
A
Q
Y
R
E
V
A
A
F
A
-----
L
D
A
S
T
K
Q
T
L
V
R
G
E
R
L
T
Q
L
L
K
Q
N
Q
Y
S
P
L
A
T
E
E
Q
V
P
L
I
Y
A
G
V
N
G
H
L
D
G
I
E
L
S
R
I
G
E
F
E
S
S
F
L
S
Y
L
K
S
N
H
N
E
L
L
T
E
I
R
E
K
G
E
L
S
K
--
E
L
L
A
S
--
L
K
S
A
T
E
S
F
V
A
T
-----
5
PsiBlast_PDB
90.34
58%
-101
- C6 -
2R9V
4
ATPA_THEMA
A:
[29-510]
----------------
K
S
F
E
E
K
I
D
L
E
D
T
G
K
V
I
Q
V
G
D
G
I
A
R
A
Y
G
L
N
K
V
M
V
S
E
L
V
E
F
V
E
-
T
G
V
K
G
V
A
F
N
L
E
E
D
N
V
G
I
I
I
L
G
E
Y
K
D
I
K
E
G
H
T
V
R
R
L
K
R
I
I
E
V
P
V
G
E
E
L
L
G
R
V
V
N
P
L
G
E
P
L
D
G
K
G
P
I
N
A
-
K
N
F
R
P
I
E
I
K
A
P
G
V
I
Y
R
K
P
V
D
T
P
L
Q
T
G
I
K
A
I
D
S
M
I
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
A
I
A
I
D
T
I
I
N
Q
K
----
G
Q
G
----
V
Y
C
I
Y
V
A
I
G
Q
K
K
S
A
I
A
R
I
I
D
K
L
R
Q
Y
G
A
M
E
Y
T
T
V
V
V
A
S
A
S
D
P
A
S
L
Q
Y
I
A
P
Y
A
G
C
A
M
G
E
Y
F
A
Y
S
G
R
D
A
L
V
V
Y
D
D
L
S
K
H
A
V
A
Y
R
Q
L
S
L
L
M
R
R
P
P
G
R
E
A
Y
P
G
D
I
F
Y
L
H
S
R
L
L
E
R
A
V
R
L
N
D
K
L
G
G
G
S
L
T
A
L
P
I
V
E
T
Q
A
N
D
I
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
Y
L
E
P
G
L
F
Y
A
G
Q
R
P
A
I
N
V
G
L
S
V
S
R
V
G
G
S
A
Q
I
K
A
M
K
Q
V
A
G
M
L
R
I
D
L
A
Q
Y
R
E
L
E
T
F
A
Q
F
A
T
E
L
D
P
A
T
R
A
Q
I
I
R
G
Q
R
L
M
E
L
L
K
Q
E
Q
Y
S
P
M
P
V
E
E
Q
V
V
V
L
F
A
G
V
R
G
Y
L
D
D
L
P
V
E
E
V
R
R
F
E
K
E
F
L
R
F
M
H
E
K
H
Q
D
I
L
D
D
I
K
T
K
K
E
L
T
S
--
E
--
T
E
E
K
L
K
K
A
I
E
E
F
K
T
T
F
R
V
--
84
PsiBlast_CBE
90.32
59%
-96
- C6 -
1H8E
5
ATPA_BOVIN
A:
[19-494]
------------------
A
D
T
S
V
D
L
E
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
E
F
-
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
-
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
RFND
G
T
D
EKK
K
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
------
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
S
H
V
I
S
Q
H
Q
A
L
L
G
K
I
R
T
D
G
K
I
S
E
--
E
--
S
D
--
A
K
L
K
E
I
V
T
N
F
L
A
G
F
E
-
87
PsiBlast_CBE
90.25
59%
-96
- C6 -
1E79
3
ATPA_BOVIN
A:
[19-494]
------------------
A
D
T
S
V
D
L
E
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
E
F
-
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
-
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
RFND
G
T
D
EKK
K
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
S
H
V
I
S
Q
H
Q
A
L
L
G
K
I
R
T
D
G
K
I
S
E
--
E
--
S
D
--
A
K
L
K
E
I
V
T
N
F
L
A
G
F
E
-
106
PsiBlast_CBE
90.10
56%
-98
- C6 -
3ZIA
2
ATPA_YEAST
A:
[26-506]
-----------------------
N
L
N
E
T
G
R
V
L
A
V
G
D
G
I
A
R
V
F
G
L
N
N
I
Q
A
E
E
L
V
E
F
-
S
-
S
G
V
K
G
M
A
L
N
L
E
P
G
Q
V
G
I
V
L
F
G
S
D
R
L
V
K
E
G
E
L
V
K
R
T
G
N
I
V
D
V
P
V
G
P
G
L
L
G
R
V
V
D
A
L
G
N
P
I
D
G
K
G
P
I
D
A
-
A
G
R
S
R
A
Q
V
K
A
P
G
I
L
P
R
R
S
V
H
E
P
V
Q
T
G
L
K
A
V
D
A
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
A
V
A
L
D
T
I
L
N
Q
K
RWNN
G
S
D
ESK
K
L
Y
C
V
Y
V
A
V
G
Q
K
R
S
T
V
A
Q
L
V
Q
T
L
E
Q
H
D
A
M
K
Y
S
I
I
V
A
A
T
A
S
E
A
A
P
L
Q
Y
L
A
P
F
T
A
A
S
I
G
E
W
F
R
D
N
G
K
H
A
L
I
V
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
L
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
L
S
E
K
E
G
S
G
S
L
T
A
L
P
V
I
E
T
Q
G
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
A
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
V
K
A
L
K
Q
V
A
G
S
L
K
L
F
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
S
T
K
Q
T
L
V
R
G
E
R
L
T
Q
L
L
K
Q
N
Q
Y
S
P
L
A
T
E
E
Q
V
P
L
I
Y
A
G
V
N
G
H
L
D
G
I
E
L
S
R
I
G
E
F
E
S
S
F
L
S
Y
L
K
S
N
H
N
E
L
L
T
E
I
R
E
K
G
E
L
S
K
--
E
L
L
A
S
--
L
K
S
A
T
E
S
F
V
A
T
-----
85
PsiBlast_CBE
90.07
59%
-94
- C6 -
1E79
3
ATPA_BOVIN
C:
[19-494]
------------------
A
D
T
S
V
D
L
E
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
E
F
-
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
-
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
RFND
G
T
D
EKKK
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
S
H
V
I
S
Q
H
Q
A
L
L
G
K
I
R
T
D
G
K
I
S
E
--
E
--
S
D
--
A
K
L
K
E
I
V
T
N
F
L
A
G
F
E
-
67
PsiBlast_CBE
90.01
59%
-95
- C6 -
1W0K
4
ATPA_BOVIN
C:
[19-494]
------------------
A
D
T
S
V
D
L
E
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
E
F
-
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
-
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
RFND
G
T
D
EKK
K
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
S
H
V
I
S
Q
H
Q
A
L
L
G
K
I
R
T
D
G
K
I
S
E
--
E
--
S
D
--
A
K
L
K
E
I
V
T
N
F
L
A
G
F
E
-
94
PsiBlast_CBE
89.83
59%
-95
- C6 -
1BMF
3
ATPA_BOVIN
C:
[19-494]
------------------
A
D
T
S
V
D
L
E
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
E
F
-
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
-
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
RFND
G
T
D
EKKK
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
S
H
V
I
S
Q
H
Q
A
L
L
G
K
I
R
T
D
G
K
I
S
E
--
E
--
S
D
--
A
K
L
K
E
I
V
T
N
F
L
A
G
F
E
-
52
PsiBlast_CBE
89.66
59%
-97
- C6 -
4ASU
3
ATPA_BOVIN
C:
[24-494]
-----------------------
D
L
E
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
E
F
-
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
-
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
RFND
G
T
D
EKK
K
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
--
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
S
H
V
I
S
Q
H
Q
A
L
L
G
K
I
R
T
D
G
K
I
S
E
--
E
--
S
D
--
A
K
L
K
E
I
V
T
N
F
L
A
G
F
E
-
86
PsiBlast_CBE
89.59
59%
-94
- C6 -
1E79
4
ATPA_BOVIN
B:
[19-494]
------------------
A
D
T
S
V
D
L
E
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
E
F
-
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
-
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
RFND
G
T
D
EKKK
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
Q
F
G
S
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
S
H
V
I
S
Q
H
Q
A
L
L
G
K
I
R
T
D
G
K
I
S
E
--
E
--
S
D
--
A
K
L
K
E
I
V
T
N
F
L
A
G
F
E
-
82
PsiBlast_CBE
89.57
59%
-95
- C6 -
1H8E
6
ATPA_BOVIN
C:
[19-494]
------------------
A
D
T
S
V
D
L
E
E
T
G
R
V
L
S
I
G
D
G
I
A
R
V
H
G
L
R
N
V
Q
A
E
E
M
V
E
F
-
S
-
S
G
L
K
G
M
S
L
N
L
E
P
D
N
V
G
V
V
V
F
G
N
D
K
L
I
K
E
G
D
I
V
K
R
T
G
A
I
V
D
V
P
V
G
E
E
L
L
G
R
V
V
D
A
L
G
N
A
I
D
G
K
G
P
I
G
S
-
K
A
R
R
R
V
G
L
K
A
P
G
I
I
P
R
I
S
V
R
E
P
M
Q
T
G
I
K
A
V
D
S
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
S
I
A
I
D
T
I
I
N
Q
K
RFND
G
T
D
EKK
K
L
Y
C
I
Y
V
A
I
G
Q
K
R
S
T
V
A
Q
L
V
K
R
L
T
D
A
D
A
M
K
Y
T
I
V
V
S
A
T
A
S
D
A
A
P
L
Q
Y
L
A
P
Y
S
G
C
S
M
G
E
Y
F
R
D
N
G
K
H
A
L
I
I
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
M
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
K
M
N
D
A
F
G
G
G
S
L
T
A
L
P
V
I
E
T
Q
A
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
T
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
T
R
A
M
K
Q
V
A
G
T
M
K
L
E
L
A
Q
Y
R
E
V
A
A
F
A
----
D
L
D
A
A
T
Q
Q
L
L
S
R
G
V
R
L
T
E
L
L
K
Q
G
Q
Y
S
P
M
A
I
E
E
Q
V
A
V
I
Y
A
G
V
R
G
Y
L
D
K
L
E
P
S
K
I
T
K
F
E
N
A
F
L
S
H
V
I
S
Q
H
Q
A
L
L
G
K
I
R
T
D
G
K
I
S
E
--
E
--
S
D
--
A
K
L
K
E
I
V
T
N
F
L
A
G
F
E
-
120
PsiBlast_CBE
89.52
56%
-102
- C6 -
3FKS
16
ATPA_YEAST
T:
[25-506]
----------------------
A
N
L
N
E
T
G
R
V
L
A
V
G
D
G
I
A
R
V
F
G
L
N
N
I
Q
A
E
E
L
V
E
F
-
S
-
S
G
V
K
G
M
A
L
N
L
E
P
G
Q
V
G
I
V
L
F
G
S
D
R
L
V
K
E
G
E
L
V
K
R
T
G
N
I
V
D
V
P
V
G
P
G
L
L
G
R
V
V
D
A
L
G
N
P
I
D
G
K
G
P
I
D
A
-
A
G
R
S
R
A
Q
V
K
A
P
G
I
L
P
R
R
S
V
H
E
P
V
Q
T
G
L
K
A
V
D
A
L
V
P
I
G
R
G
Q
R
E
L
I
I
G
D
R
Q
T
G
K
T
A
V
A
L
D
T
I
L
N
Q
K
RWNN
G
S
D
ESKK
L
Y
C
V
Y
V
A
V
G
Q
K
R
S
T
V
A
Q
L
V
Q
T
L
E
Q
H
D
A
M
K
Y
S
I
I
V
A
A
T
A
S
E
A
A
P
L
Q
Y
L
A
P
F
T
A
A
S
I
G
E
W
F
R
D
N
G
-
H
A
L
I
V
Y
D
D
L
S
K
Q
A
V
A
Y
R
Q
L
S
L
L
L
R
R
P
P
G
R
E
A
Y
P
G
D
V
F
Y
L
H
S
R
L
L
E
R
A
A
-
L
S
E
K
E
G
S
-
S
L
T
A
L
P
V
I
E
T
Q
G
G
D
V
S
A
Y
I
P
T
N
V
I
S
I
T
D
G
Q
I
F
L
E
A
E
L
F
Y
K
G
I
R
P
A
I
N
V
G
L
S
V
S
R
V
G
S
A
A
Q
V
K
A
L
K
Q
V
A
G
S
L
K
L
F
L
A
Q
Y
R
E
V
A
--------
L
D
A
S
T
K
Q
T
L
V
R
G
E
R
L
T
Q
L
L
K
Q
N
Q
Y
S
P
L
A
T
E
E
Q
V
P
L
I
Y
A
G
V
-
G
H
L
D
G
I
E
L
S
R
I
G
E
F
E
S
S
F
L
S
Y
L
K
S
N
H
N
E
L
L
T
E
I
R
E
K
G
E
L
S
K
--
E
LL
A
S
--
L
K
S
A
T
E
S
F
V
A
T
-----