@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0898: (2015-12-04 )
MAFDVIMPKLGVDMQEGEILEWKKNEGDTVNEGDVLLEIMSDKTNMEIEAEDTGVLLKIVHQAGDVVPVTEVIAYIGEEGEEVGTSSPSADATITAEDGQSVSGPAAPSQETVAAATPKEELAADEYDIVVVGGGPAGYYAAIRGAQLGGKIAIVEKTEFGGTCLNVGCIPTKTYLKNAEILDGLKVAAGRGINLASTNYAIDMDKTVAFKNSVVKTLTGGVRGLLKANKVEIFNGLGQVNPDKSVVIGDKVIKGRNVVLATGSKVSRINIPGIESPLVLTSDDILDLREIPKSLAVMGGGVVGIELGLVWASYGVDVTVIEMADRIIPAMDKEVSLELQKILAKKGMKIKTSVGVSEIVEANNQLTLKLNNGEEVVADKALLSIGRVPQMNGLENLEPELEMERGRIKVNAYQETSIPGIYAPGDVNGTRMLAHAAYRMGEVAAENALGGNKRKAHLDFTPAAVYTHPEVAMVGMTEEQAREQYGDILVGKNSFTGNGRAIASNEAHGFVKVIAEPKYKEILGVHIIGPAAAELINEASTIMENELTVYDVAQSIHGHPTFSEVMYEAFLDVLGEAIHNPPKRK
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.....-------.-------.-160.......170....----...180-.----.----..-.--.-.-.---190------.......-.200.......210.......220.......230.......-240....--..-----.-----------250.........260.......270..--..----...----.280.......-290........300.......310.......320.......-330.......340...-....350-........360..---.--...-------.--370---.-----.----.---.----.--.-.---..380...-----....390--.......-400-.-.-.-.-....410.......420.....-..430........440.......450----.........460--....----....470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
F
D
V
IMPKLGVDMQEG
E
I
L
E
W
KKNEGDTVNE
G
D
V
L
L
E
I
MSDKTN
M
E
I
EAEDT
G
V
L
L
K
I
V
H
QAGDV
V
P
V
T
E
V
I
A
Y
IGEE
G
E
EVGTSSPSA
D
A
T
I
T
AEDGQSVSGPAAPSQETVAAAT
P
K
E
E
LAADEY
D
I
V
V
VGGGP
A
G
Y
Y
A
A
IRGAQLG
G
K
I
A
I
V
E
K-------T-------E-FG
G
T
C
L
NVGCIP
T
K
T
YL----KN
A
E
I
--
L
----D----
G
L
-
K
--V-A-A---GR-------GINLAST-
N
Y
A
I
DMD
K
T
V
A
F
K
N
S
V
V
K
T
L
T
G
G
V
R
G
L
L
KAN
K
V
E
I
FNGLGQ-VNPDK
S
V
--
V
I-----G-----------D--KVIKGR
N
V
V
L
ATG
S
K
V
S
R
I
N-IPG--IE----S
P
L
----
V
LTS
D
D
I
L
D
L
R
-
E
-
I
P
K
S
L
A
V
MGG
G
V
V
G
I
E
L
G
L
V
W
ASYGV
D
V
T
V
I
E
M
A
D
R
I
IP-AMD
K
E
V
S
L
E
L
Q
K
I
L
A
K-KG
M
K
I
K
--TSV
G
V
S
E
I
V
EAN
N
---
Q
--
L
T
L
-------
K
--L-----N-----N----G---
E
----
E
--
V
-
V
---
A
D
K
A
L
L
SI-----GRVPQMN--GLENLEP-E-L-E-M-E-R-
G
R
I
K
V
N
A
Y
QETSIP
G
I
YAPGDV-N
G
T
-
R
M
L
A
H
A
A
Y
R
M
G
E
V
A
A
ENALG------GNK
R
K
A
H
LDF-T--PA
A
V
----YTHP
E
V
A
M
VGM
T
E
E
Q
A
R
E
QYG
D
I
L
VGKNSFTGN
G
R
A
IASNEAH
G
F
V
K
VIAEP
K
Y
K
E
I
L
G
V
H
I
I
G
P
A
A
A
E
L
I
N
E
A
S
T
I
M
ENE
L
T
V
Y
D
V
A
Q
S
IHGHP
T
F
S
E
V
M
Y
E
A
F
L
D
V
L
G
E
A
IHNPPKRK
104
HHSearch
91.42
43%
-92
- C3 -
2EQ6
2
?
A:
[4-458]
---------------------------------------------------------------------------------------------------------------------------
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
-------
E
-
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
----
H
A
A
E
T
--
L
----
H
----
H
L
-
K
--
V
-
A
-
E
---
G
F
-------
G
L
K
A
----
K
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
-
L
V
G
P
K
E
V
--
E
V
-----
G
-----------
G
--
E
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
--------
G
E
D
----
V
W
D
S
T
R
A
L
K
V
E
E
G
-
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
-
Q
G
D
P
E
T
A
A
L
L
R
R
A
L
E
K
-
E
G
I
R
V
R
--
T
K
T
K
A
V
G
Y
E
K
K
K
D
---
G
--
L
H
V
-------
R
--
L
E
PAEG
G
-----
E
----
G
---
E
----
E
--
V
-
V
---
V
D
K
V
L
V
A
V
-----
G
R
K
P
R
T
E
--
G
L
G
-
L
E
K
-
A
G
V
-
K
V
D
-
E
-
R
-
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
-
A
R
P
-
P
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
------
K
D
S
-
A
F
D
Y
-
Q
-
V
--
P
S
V
V
----
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
L
N
---
21
PsiBlast_CBE
91.08
40%
-89
- C3 -
3LAD
2
DLDH_AZOVI
B:
[1-472]
---------------------------------------------------------------------------------------------------------------------------
S
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
YKGKEGK
T
-------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
DSSY
K
F
H
E
A
--
H
----
E
----
S
F
-
K
--
L
--------
H
-------
G
I
S
--
T
G
-
E
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
K
-
L
L
A
G
K
K
V
--
E
V
TAADG
S
-----------
S
--
Q
V
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
-
P
A
P
--
V
D
----
Q
D
V
----
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
-
A
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
-
Q
G
L
K
I
L
--
L
G
A
R
V
T
G
T
E
V
K
N
K
---
Q
--
V
T
V
-------
K
--
F
-----
V
-----
D
----
A
---
E
GEK-
S
--
Q
-
A
---
F
D
K
L
I
V
A
V
-----
G
R
R
P
V
T
T
--
D
L
L
A
A
D
S
-
G
-
V
-
T
-
L
D
E
-
R
-
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
-
V
R
G
-
A
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
-
I
A
------
G
H
K
A
Q
M
N
Y
D
L
-
I
--
P
A
V
I
----
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
V
A
----
103
HHSearch
90.70
42%
-92
- C3 -
3LAD
2
DLDH_AZOVI
A:
[1-472]
---------------------------------------------------------------------------------------------------------------------------
S
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
-------
Y
KGKEGKT
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
----
D
S
S
Y
K
--
F
----
H
----
E
A
-
H
E-
S
-
F
-
K
---
L
H
-------
G
I
S
T
G
---
E
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
K
-
L
L
A
G
K
K
V
--
E
V
-----
T
A
ADGS------
S
--
Q
V
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
-
P
A
P
--
V
D
----
Q
D
V
----
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
-
A
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
-
Q
G
L
K
I
L
--
L
G
A
R
V
T
G
T
E
V
K
N
K
---
Q
--
V
T
V
-------
K
--
F
-----
V
-----
D
A
E
G
-
E
---
K
----
S
--
Q
-
A
---
F
D
K
L
I
V
A
V
-----
G
R
R
P
V
T
T
--
D
L
L
-
A
A
D
-
S
G
V
-
T
L
D
-
E
-
R
-
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
-
V
R
G
-
A
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
------
H
K
A
-
Q
M
N
Y
D
L
-
I
--
P
A
V
I
----
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
V
A
----
14
PsiBlast_PDB
90.65
40%
-93
- C3 -
1EBD
2
DLDH1_GEOSE
A:
[1-450]
---------------------------------------------------------------------------------------------------------------------------
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
-------
N
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
----
S
A
S
H
R
--
Y
----
E
----
Q
A
-
K
--
H
-
S
-
E
---
E
M
-------
G
I
K
--
A
E
-
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
-
F
V
D
A
N
T
V
R
V
V
N
-----
G
-----------
D
S
A
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
--
P
I
E
-
L
P
N
--
F
K
F---
S
N
R
----
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
-
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
-
K
G
V
E
V
V
--
T
N
A
L
A
K
G
A
E
E
R
E
D
---
G
--
V
T
V
-------
T
--
Y
-----
E
A
----
N
----
G
---
E
----
T
K
T
I
-
D
---
A
D
Y
V
L
V
T
V
-----
G
R
R
P
N
T
D
EL
G
L
E
Q
I
G
I
-
K
-
M
---
T
-
N
-
R
-
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
-
V
P
G
-
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
-
A
I
A
------
G
H
P
S
A
V
D
Y
V
A
-
I
--
P
A
V
V
----
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
E
V
A
L
-----------
1
PsiBlast_PDB
90.53
40%
-94
- C3 -
3LAD
2
DLDH_AZOVI
A:
[1-472]
---------------------------------------------------------------------------------------------------------------------------
S
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
YKGKEGK
T
-------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
F
H
E
A
--
H
----
E
----
S
F
-
K
--
L
--------
H
-------
G
I
S
--
T
G
-
E
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
K
-
L
L
A
G
K
K
V
--
E
V
T
A
ADG
S
-----------
S
--
Q
V
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
-
P
A
P
--
V
D
----
Q
D
V
----
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
-
A
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
-
Q
G
L
K
I
L
--
L
G
A
R
V
T
G
T
E
V
K
N
K
---
Q
--
V
T
V
-------
K
--
F
-----
V
-----
D
----
A
---
E
G
E
K
-
S
--
Q
-
A
---
F
D
K
L
I
V
A
V
-----
G
R
R
P
V
T
T
--
D
L
L
A
A
D
S
-
G
-
V
-
T
-
L
D
E
-
R
-
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
-
V
R
G
-
A
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
-
I
A
------
G
H
K
A
Q
M
N
Y
D
L
-
I
--
P
A
V
I
----
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
V
A
----
114
HHSearch
90.50
40%
-96
- C3 -
1EBD
2
DLDH1_GEOSE
A:
[2-455]
----------------------------------------------------------------------------------------------------------------------------
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
-------
N
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
----
S
A
S
H
R
--
Y
----
E
----
Q
A
-
K
--
H
-
S
-
E
---
E
M
-------
G
I
K
A
E
---
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
-
F
V
D
A
N
T
V
--
R
V
-----
V
N
GD
S
-------
A
--
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
-
N
F
K
--
F
-----
S
N
R
----
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
-
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
-
K
G
V
E
V
V
--
T
N
A
L
A
K
G
A
E
E
R
E
D
---
G
--
V
T
V
-------
T
--
Y
-----
E
A
----
N
----
G
E
T
-
K
----
T
--
I
-
D
---
A
D
Y
V
L
V
T
V
-----
G
R
R
P
N
T
D
--
E
L
G
-
L
E
Q
-
I
G
I
-
K
M
T
-
N
-
R
-
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
-
V
P
G
-
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
------
H
P
S
-
A
V
D
Y
V
A
-
I
--
P
A
V
V
----
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
E
V
A
L
-----------
72
PsiBlast_CBE
89.34
40%
-93
- C3 -
1EBD
2
DLDH1_GEOSE
B:
[1-450]
---------------------------------------------------------------------------------------------------------------------------
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-------
G
-------
N
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
----
S
A
S
H
R
--
Y
----
E
----
Q
A
-
K
--
H
-
S
-
E
---
E
M
-------
G
I
K
--
A
E
-
N
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
-
F
V
D
A
N
T
V
RV
V
N
-----
G
-----------
D
SA
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
--
P
I
E
-
L
P
N
--
F
K
F---
S
N
R
----
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
-
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
-
K
G
V
E
V
V
--
T
N
A
L
A
K
G
A
E
E
R
E
D
---
G
--
V
T
V
-------
T
--
Y
-----
E
A----
N
----
G
---
E
----
T
KT
I
-
D
---
A
D
Y
V
L
V
T
V
-----
G
R
R
P
N
T
D
EL
G
L
E
Q
I
G
I
-
K
-
M
---
T
-
N
-
R
-
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
-
V
P
G
-
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
-
A
I
A
------
G
H
P
S
A
V
D
Y
V
A
-
I
--
P
A
V
V
----
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
E
V
A
L
-----------
102
HHSearch
89.28
40%
-95
* C3 *
3URH
3
?
A:
[26-486]
------------------------------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
-------
R
S------
T
-
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
----
H
A
S
E
M
--
F
----
H
----
Q
A
-
Q
--
H
G
L
-
E
---
A
L
-------
G
V
E
V
A
---
N
P
K
L
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
K
-
V
L
G
Q
G
K
V
--
S
V
-----
T
N
EKG
E
------
E
--
Q
V
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
G
---
I
P
G
--
V
E
V
A
F
D
E
K
T
----
I
V
S
S
T
G
A
L
A
L
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
-
G
M
D
G
E
V
A
K
Q
L
Q
R
M
L
T
K
-
Q
G
I
D
F
K
--
L
G
A
K
V
T
G
A
V
K
S
G
D
---
G
--
A
K
V
-------
T
--
F
-----
E
PVKG
G
E
----
A
---
T
----
T
--
L
-
D
---
A
E
V
V
L
I
A
T
-----
G
R
K
P
S
T
D
--
G
L
G
-
L
A
K
-
A
G
V
-
V
L
D
-
S
-
R
-
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
-
V
R
G
-
P
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
A
G
------
Q
A
G
-
H
V
N
Y
D
V
-
I
--
P
G
V
V
----
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
----------
17
PsiBlast_PDB
88.47
38%
-96
- C3 -
3URH
3
?
A:
[26-486]
------------------------------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
R------
S
-------
T
-
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
----
H
A
S
E
M
--
F
----
H
Q
A
Q
H
G
L
-
E
--
A
-
L
--------------
G
V
E
V
A
---
N
P
K
L
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
K
-
V
L
G
Q
G
K
V
--
S
V
-----
T
N
EKG
E
------
E
--
Q
V
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
--
G
-
I
P
G
--
V
E
----
V
A
F
DEKT
I
V
S
S
T
G
A
L
A
L
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
-
G
M
D
G
E
V
A
K
Q
L
Q
R
M
L
T
K
-
Q
G
I
D
F
K
--
L
G
A
K
V
T
G
A
V
K
S
G
D
G
A
-
K
--
V
T
F
-------
E
--
P
-----
V
-----
K
----
G
---
G
----
E
--
A
-
T
T
L
D
A
E
V
V
L
I
A
T
-----
G
R
K
P
S
T
D
--
G
L
G
L
A
K
A
-
G
-
V
-
V
-
L
-
D
S
R
-
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
-
V
R
G
-
P
M
L
A
H
K
A
E
D
E
G
-
V
A
V
A
E
I
I
A
------
G
Q
A
G
H
V
N
Y
D
V
-
I
--
P
G
V
V
----
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
----------
99
HHSearch
88.27
40%
-89
- C3 -
2QAE
2
DLDH_TRYCR
A:
[1-464]
----------------------------------------------------------------------------------------------------------------------------
N
P
Y
D
V
V
V
I
G
G
G
P
G
G
Y
V
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
-------
R
G------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
----
H
A
T
H
L
--
Y
----
H
----
D
A
-
H
--
A
N
F
-
A
---
R
Y
-------
G
L
M
G
G
-
E
-
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
-
F
E
T
A
H
S
I
--
R
V
-----
N
GLDG
K
------
Q
--
E
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
-
F
L
P
--
F
D
----
E
K
V
----
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
-
T
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
E
K
M
K
F
M
--
T
S
T
K
V
V
G
G
T
N
N
G
D
---
S
--
V
S
L
E
V
-----
E
-------------------
G
K
R
-
E
----
T
--
V
-
T
---
C
E
A
L
L
V
S
V
-----
G
R
R
P
F
T
G
--
G
L
G
-
L
D
K
-
I
N
V
-
A
K
N
-
E
-
R
-
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
-
V
D
K
G
P
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
------
K
P
G
-
H
V
N
Y
G
V
-
I
--
P
A
V
I
----
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
F
-----
13
PsiBlast_PDB
88.09
40%
-88
- C3 -
1DXL
2
DLDH_PEA
A:
[4-469]
---------------------------------------------------------------------------------------------------------------------------
S
D
E
N
D
V
V
I
I
G
G
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
T
C
I
E
K
-------
R
G------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
----
H
S
S
H
M
--
Y
----
H
----
E
A
-
K
--
H
-
S
F
A
---
N
H
-------
G
V
K
V
--
S
-
N
V
E
I
D
L
A
A
M
M
G
Q
K
D
K
A
V
S
N
L
T
R
G
I
E
G
L
F
K
K
N
K
V
T
Y
V
K
G
Y
G
K
F
V
S
P
S
E
I
S
--
V
D
-----
T
IEG
E
-------
N
--
T
V
V
K
G
K
H
I
I
I
A
T
G
S
D
V
K
--
S
-
L
P
G
V
T
I
D
----
E
K
K
----
I
V
S
S
T
G
A
L
A
L
S
-
E
-
I
P
K
K
L
V
V
I
G
A
G
Y
I
G
L
E
M
G
S
V
W
G
R
I
G
S
E
V
T
V
V
E
F
A
S
E
I
V
P
-
T
M
D
A
E
I
R
K
Q
F
Q
R
S
L
E
K
-
Q
G
M
K
F
K
--
L
K
T
K
V
V
G
V
D
T
S
G
D
---
G
--
V
K
L
-------
T
--
V
-----
E
PSA--
G
----
G
---
E
----
Q
--
T
-
I
I
E
-
A
D
V
V
L
V
S
A
-----
G
R
T
P
F
T
S
--
G
L
N
L
D
K
I
-
G
-
V
-
E
-
T
-
D
-
K
L
G
R
I
L
V
N
E
R
F
S
T
N
V
S
G
V
Y
A
I
G
D
V
-
I
P
G
-
P
M
L
A
H
K
A
E
E
D
G
-
V
A
C
V
E
Y
L
A
------
G
K
V
G
H
V
D
Y
D
K
-
V
--
P
G
V
V
----
Y
T
N
P
E
V
A
S
V
G
K
T
E
E
Q
V
K
E
T
G
V
E
Y
R
V
G
K
F
P
F
M
A
N
S
R
A
K
A
I
D
N
A
E
G
L
V
K
I
I
A
E
K
E
T
D
K
I
L
G
V
H
I
M
A
P
N
A
G
E
L
I
H
E
A
A
I
A
L
Q
Y
D
A
S
S
E
D
I
A
R
V
C
H
A
H
P
T
M
S
E
A
I
K
E
A
A
M
A
T
Y
D
K
P
I
H
I
-----
112
HHSearch
87.74
39%
-94
- C3 -
2YQU
4
?
A:
[1-452]
-----------------------------------------------------------------------------------------------------------------------------
M
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-------
E
K------
A
-
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
----
E
T
T
E
R
--
I
----
Y
----
E
A
-
K
--
K
-
G
-----
L
L
-------
G
A
K
V
K
---
G
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
-
F
L
S
E
R
K
V
--
L
V
EE---
T
-----------
G
--
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
-
W
A
Q
--
V
D
----
Y
E
R
----
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
-
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
--
T
G
V
R
V
T
A
V
V
P
E
A
K
---
G
--
A
R
V
-------
E
--
L
-----
E
-----
G
----
G
---
E
----
V
--
L
-
E
---
A
D
R
V
L
V
A
V
-----
G
R
R
P
Y
T
E
--
G
L
S
-
L
E
N
-
A
G
L
-
S
T
D
-
E
-
R
-
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
-
V
R
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
------
G
F
G
-
H
V
D
Y
Q
A
-
I
--
P
S
V
V
----
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
L
-----
100
HHSearch
87.49
39%
-90
- C3 -
1ZMD
3
DLDH_HUMAN
A:
[3-470]
--------------------------------------------------------------------------------------------------------------------------
Q
P
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
-------
N
E------
T
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
----
N
N
S
H
Y
--
Y
----
H
----
M
A
-
H
G
T
D
-
F
-
A
---
S
R
-------
G
I
E
M
S
---
E
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
-
I
T
G
K
N
Q
V
--
T
A
-----
T
K
ADG
G
------
T
--
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
-
G
I
T
--
I
D
----
E
D
T
----
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
--
L
N
T
K
V
T
G
A
T
K
K
S
D
G--
K
--
I
D
V
-------
S
I
E
A
-----
A
-----
S
----
G
GK
A
E
----
V
--
I
-
T
---
C
D
V
L
L
V
C
I
-----
G
R
R
P
F
T
K
--
N
L
G
-
L
E
E
-
L
G
I
-
E
L
D
-
P
-
R
-
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
-
V
A
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
------
G
A
V
-
H
I
D
Y
N
C
-
V
--
P
S
V
I
----
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
S
F
G
K
S
I
N
F
----
5
PsiBlast_PDB
87.37
38%
-96
- C3 -
2YQU
4
?
A:
[2-454]
------------------------------------------------------------------------------------------------------------------------------
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-------
E
-------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
----
E
T
T
E
R
--
I
Y
E
A
K
K
----
G
L
-
L
--
G
-
A
-
K
---
V
K
-------
G
V
E
L
--------
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
-
F
L
S
E
R
K
V
--
L
V
-----
E
-----------
E
TG
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
-
W
A
Q
--
V
D
----
Y
E
R
----
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
-
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
--
T
G
V
R
V
T
A
V
V
P
E
A
K
---
G
--
A
R
V
-------
E
--
L
-----
E
-----
G
----
G
---
E
----
V
--
L
-
E
---
A
D
R
V
L
V
A
V
-----
G
R
R
P
Y
T
E
--
G
L
S
L
E
N
A
-
G
-
L
-
S
-
T
D
E
-
R
-
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
-
V
R
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
------
G
F
---
G
H
V
D
Y
-
Q
A
I
P
S
V
V
----
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
L
-----
109
HHSearch
87.30
40%
-92
- C3 -
1DXL
2
DLDH_PEA
A:
[4-467]
---------------------------------------------------------------------------------------------------------------------------
S
D
E
N
D
V
V
I
I
G
G
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
T
C
I
E
K
-------
R
G------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
----
H
S
S
H
M
--
Y
----
H
----
E
A
-
K
--
H
S
F
-
A
---
N
H
-------
G
V
K
V
S
---
N
V
E
I
D
L
A
A
M
M
G
Q
K
D
K
A
V
S
N
L
T
R
G
I
E
G
L
F
K
K
N
K
V
T
Y
V
K
G
Y
G
K
-
F
V
S
P
S
E
I
--
S
V
-----
D
T
IEG
E
------
N
--
T
V
V
K
G
K
H
I
I
I
A
T
G
S
D
V
K
S
L
P
-
G
V
T
--
I
D
----
E
K
K
----
I
V
S
S
T
G
A
L
A
L
S
-
E
-
I
P
K
K
L
V
V
I
G
A
G
Y
I
G
L
E
M
G
S
V
W
G
R
I
G
S
E
V
T
V
V
E
F
A
S
E
I
V
P
-
T
M
D
A
E
I
R
K
Q
F
Q
R
S
L
E
K
-
Q
G
M
K
F
K
--
L
K
T
K
V
V
G
V
D
T
S
G
D
---
G
--
V
K
L
-------
T
--
V
-----
E
PSAGG
E
----
Q
---
T
----
I
--
I
-
E
---
A
D
V
V
L
V
S
A
-----
G
R
T
P
F
T
S
--
G
L
N
-
L
D
K
-
I
G
V
-
E
T
D
-
K
-
L
-
G
R
I
L
V
N
E
R
F
S
T
N
V
S
G
V
Y
A
I
G
D
V
-
I
P
G
-
P
M
L
A
H
K
A
E
E
D
G
V
A
C
V
E
Y
L
A
G
------
K
V
G
-
H
V
D
Y
D
K
-
V
--
P
G
V
V
----
Y
T
N
P
E
V
A
S
V
G
K
T
E
E
Q
V
K
E
T
G
V
E
Y
R
V
G
K
F
P
F
M
A
N
S
R
A
K
A
I
D
N
A
E
G
L
V
K
I
I
A
E
K
E
T
D
K
I
L
G
V
H
I
M
A
P
N
A
G
E
L
I
H
E
A
A
I
A
L
Q
Y
D
A
S
S
E
D
I
A
R
V
C
H
A
H
P
T
M
S
E
A
I
K
E
A
A
M
A
T
Y
D
K
P
I
H
I
-----
32
PsiBlast_CBE
87.24
38%
-95
- C3 -
2YQU
6
?
B:
[2-454]
------------------------------------------------------------------------------------------------------------------------------
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-------
E
-------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
----
E
T
T
E
R
--
I
YEAK
K
----
G
L
-
L
--
G
-
A
-
K
---
V
K
-------
G
V
E
L
--------
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
-
F
L
S
E
R
K
V
--
L
V
-----
E
-----------
E
TG
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
-
W
A
Q
--
V
D
----
Y
E
R
----
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
-
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
--
T
G
V
R
V
T
A
V
V
P
E
A
K
---
G
--
A
R
V
-------
E
--
L
-----
E
-----
G
----
G
---
E
----
V
--
L
-
E
---
A
D
R
V
L
V
A
V
-----
G
R
R
P
Y
T
E
--
G
L
S
L
E
N
A
-
G
-
L
-
S
-
T
D
E
-
R
-
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
-
V
R
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
------
G
F
---
G
H
V
D
Y
-
Q
AI
P
S
V
V
----
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
L
-----
26
PsiBlast_CBE
86.95
39%
-96
- C3 -
1ZY8
2
DLDH_HUMAN
G:
[8-464]
-------------------------------------------------------------------------------------------------------------------------------
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
-------
N
-------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
----
N
N
S
H
Y
YH
M
----
A
----
H
G
-
K
--
D
-
F
-
A
---
S
R
-------
G
I
E
M
S
E
V
-
R
--
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
-
I
T
G
K
N
Q
V
--
T
A
TKADG
G
-----------
T
--
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
-
G
I
T
--
I
D
----
E
D
T
----
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
--
L
N
T
K
V
T
G
A
T
K
K
S
D
GKI
D
--
V
S
I
-------
E
--
A
-----
A
-----
S
----
G
GKA
E
----
V
--
I
-
T
---
C
D
V
L
L
V
C
I
-----
G
R
R
P
F
T
K
NL
G
L
E
E
L
G
I
-
E
-
L
-
D
---
P
-
R
-
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
-
V
A
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
------
G
---
A
V
H
I
D
Y
-
N
CV
P
S
V
I
----
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
S
F
G
K
S
I
N
F
----
15
PsiBlast_PDB
86.93
37%
-92
- C3 -
1JEH
2
DLDH_YEAST
A:
[6-477]
------------------------------------------------------------------------------------------------------------------------------
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-------
R
G------
K
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
----
N
N
S
H
L
--
F
----
H
----
Q
M
-
H
--
T
E
A
-
Q
---
K
R
-------
G
I
D
V
-
N
G
-
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
-
F
E
D
E
T
K
I
--
R
V
-----
T
P
V
D
G
LEGTVK
E
D
--
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
---
P
G
--
I
E
ID--
E
E
K
----
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
-
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
-
Q
G
L
D
F
K
--
L
S
T
K
V
I
S
A
K
R
N
D
D
---
K
--
N
V
V
E
I
V
V
E
D
T
K
--
T
-----
N
-----
K
----
Q
---
E
----
N
--
L
-
E
---
A
E
V
L
L
V
A
V
-----
G
R
R
P
Y
I
A
--
G
L
G
A
E
K
I
-
G
-
L
-
E
-
V
-
D
K
R
-
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
-
T
F
G
-
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
------
G
H
---
G
H
V
N
Y
-
N
N
I
P
S
V
M
----
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
C
-----
33
PsiBlast_CBE
86.91
38%
-97
- C3 -
2EQ7
3
?
B:
[2-452]
------------------------------------------------------------------------------------------------------------------------------
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-------
E
-------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
----
E
T
T
E
R
--
I
YEAK
K
----
G
L
-
L
--
G
-
A
-
K
---
V
K
-------
G
V
E
L
--------
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
-
F
L
S
E
R
K
V
--
L
V
-----
E
-----------
E
TG
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
-
W
A
Q
--
V
D
----
Y
E
R
----
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
-
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
--
T
G
V
R
V
T
A
V
V
P
E
A
K
---
G
--
A
R
V
-------
E
--
L
-----
E
-----
G
----
G
---
E
----
V
--
L
-
E
---
A
D
R
V
L
V
A
V
-----
G
R
R
P
Y
T
E
--
G
L
S
L
E
N
A
-
G
-
L
-
S
-
T
D
E
-
R
-
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
-
V
R
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
------
G
F
---
G
H
V
D
Y
-
Q
AI
P
S
V
V
----
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
--------
106
HHSearch
86.76
38%
-90
- C3 -
1V59
4
DLDH_YEAST
A:
[2-474]
--------------------------------------------------------------------------------------------------------------------------
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-------
R
G------
K
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
----
N
N
S
H
L
--
F
----
H
----
Q
M
-
H
T-
E
-
A
-
Q
---
K
R
-------
G
I
D
V
N
G
--
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
-
F
E
D
E
T
K
I
--
R
V
-----
T
P
V
DGLEGTVK
E
D
--
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
-
G
I
E
--
I
D
----
E
E
K
----
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
-
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
-
Q
G
L
D
F
K
--
L
S
T
K
V
I
S
A
K
R
N
D
D
---
K
N
V
V
E
I
-------
V
--
V
-----
E
DTKTN
K
----
Q
---
E
----
N
--
L
-
E
---
A
E
V
L
L
V
A
V
-----
G
R
R
P
Y
I
A
--
G
L
G
-
A
E
K
-
I
G
L
-
E
V
D
-
K
-
R
-
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
-
T
F
G
-
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
------
G
H
G
-
H
V
N
Y
N
N
-
I
--
P
S
V
M
----
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
C
-----
96
HHSearch
86.10
35%
-93
- C3 -
1LVL
2
DLDH1_PSEPU
A:
[2-455]
--------------------------------------------------------------------------------------------------------------------------
Q
T
I
Q
T
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
G
-------
Q
-------
A
-
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
----
H
V
A
E
Q
--
F
----
H
----
Q
A
-
S
--
R
-
F
-
T
E
PS
P
L
-------
G
I
S
V
A
---
S
P
R
L
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
G
V
A
A
L
L
K
K
H
G
V
K
V
V
H
G
W
A
K
-
V
L
D
G
K
Q
V
--
E
V
-----
D
-----------
G
--
Q
R
I
Q
C
E
H
L
L
L
A
T
G
S
S
S
V
E
L
P
-
M
L
P
--
L
G
-----
G
P
----
V
I
S
S
T
E
A
L
A
P
K
-
A
-
L
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
-
T
Y
D
S
E
L
T
A
P
V
A
E
S
L
K
K
-
L
G
I
A
L
H
--
L
G
H
S
V
E
G
Y
E
N
G
-----
C
----
L
-------
L
--
A
-----
N
-----
D
GK
G
G
Q
---
L
----
R
--
L
-
E
---
A
D
R
V
L
V
A
V
-----
G
R
R
P
R
T
K
--
G
F
N
-
L
E
C
-
L
D
L
-
K
M
N
---
G
-
A
A
I
A
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
V
-
A
G
E
-
P
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
I
I
A
G
------
K
A
R
-
R
F
E
P
A
A
-
I
--
A
A
V
C
----
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
L
D
C
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
T
L
G
E
A
V
Q
E
A
A
L
R
A
L
G
H
A
L
H
I
-----
22
PsiBlast_CBE
86.01
39%
-87
- C3 -
1LPF
2
DLDH_PSEFL
B:
[1-472]
---------------------------------------------------------------------------------------------------------------------------
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
YIGKEGK
V
-------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
DSSY
K
Y
H
E
A
--
K
----
E
----
A
F
-
K
--
V
--------
H
-------
G
I
E
--
A
K
-
G
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
-
L
L
A
N
K
Q
V
E-
V
T
-----
G
LDGK-------
T
--
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
-
P
A
P
--
L
S
----
D
D
I
----
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
-
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
-
Q
G
L
N
I
R
LG
A
R
V
T
A
S
E
V
K
K
K
Q
V
---
T
--
V
T
F
-------
T
--
D
-----
A
-----
N
----
G
---
E
----
Q
--
K
E
T
---
F
D
K
L
I
V
A
V
-----
G
R
R
P
V
T
T
--
D
L
L
A
A
D
S
-
G
-
V
-
T
-
L
D
E
-
R
-
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
-
V
R
G
-
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
-
I
A
------
G
H
K
A
Q
M
N
Y
D
L
-
I
--
P
S
V
I
----
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
----
74
PsiBlast_CBE
85.66
37%
-94
- C3 -
1JEH
2
DLDH_YEAST
B:
[6-477]
------------------------------------------------------------------------------------------------------------------------------
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-------
R
G------
K
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
----
N
N
S
H
L
--
F
----
H
----
Q
M
-
H
--
T
E
A
-
Q
---
K
R
-------
G
I
D
V
-
N
G
-
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
-
F
E
D
E
T
K
I
--
R
V
-----
T
PVDGLEGTVKE
D
--
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
---
P
G
--
I
E
ID--
E
E
K
----
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
-
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
-
Q
G
L
D
F
K
--
L
S
T
K
V
I
S
A
K
R
N
D
D
---
K
--
N
V
V
EIVVEDT
K
--
T
-----
N
-----
K
----
Q
---
E
----
N
--
L
-
E
---
A
E
V
L
L
V
A
V
-----
G
R
R
P
Y
I
A
--
G
L
G
A
E
K
I
-
G
-
L
-
E
-
V
-
D
K
R
-
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
-
T
F
G
-
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
------
G
H
---
G
H
V
N
Y
-
N
NI
P
S
V
M
----
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
C
-----
73
PsiBlast_CBE
85.41
37%
-93
- C3 -
1V59
3
DLDH_YEAST
B:
[6-477]
------------------------------------------------------------------------------------------------------------------------------
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-------
R
G------
K
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
----
N
N
S
H
L
--
F
----
H
----
Q
M
-
H
--
T
E
A
-
Q
---
K
R
-------
G
I
D
V
-
N
G
-
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
-
F
E
D
E
T
K
I
--
R
V
-----
T
PVDGLEGTVKE
D
--
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
---
P
G
--
I
E
ID--
E
E
K
----
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
-
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
-
Q
G
L
D
F
K
--
L
S
T
K
V
I
S
A
K
R
N
D
D
---
K
--
N
V
V
EIVVEDT
K
--
T
-----
N
-----
K
----
Q
---
E
----
N
--
L
-
E
---
A
E
V
L
L
V
A
V
-----
G
R
R
P
Y
I
A
--
G
L
G
A
E
K
I
-
G
-
L
-
E
-
V
-
D
K
R
-
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
-
T
F
G
-
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
------
G
H
---
G
H
V
N
Y
-
N
NI
P
S
V
M
----
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
C
-----
68
PsiBlast_CBE
83.75
40%
-91
- C3 -
2EQ6
2
?
B:
[7-460]
------------------------------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-------
G
-------
E
-
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
----
H
A
A
E
T
--
L
----
H
----
H
L
-
K
--
V
-
A
-
E
---
G
F
-------
G
L
K
---
A
-
K
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
-
L
V
G
P
K
E
V
--
E
V
-----
G
-----------
G
--
E
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
F
--
G
E
----
D
------
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
-
Q
G
D
P
E
T
A
A
L
L
R
R
A
L
E
K
-
E
G
I
R
V
R
--
T
K
T
K
A
V
G
Y
E
K
K
K
D
---
G
--
L
H
V
-------
R
--
L
-----
E
-----
P
----
A
---
E
----
G
--
G
-
E
---
G
E
E
V
V
V
D
K
VLVAV
G
R
K
P
R
T
E
--
G
L
G
L
E
K
A
-
G
-
V
-
K
-
V
D
E
-
R
-
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
-
A
R
P
-
P
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
---------
K
D
S
A
F
D
Y
Q
V
--
P
S
V
V
----
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
L
N
---
78
PsiBlast_CBE
83.21
37%
-94
- C3 -
3II4
3
DLDH_MYCTU
B:
[5-464]
-----------------------------------------------------------------------------------------------------------------------------
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-------
K
-------
Y
-
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
----
R
N
A
E
L
--
V
----
H
----
I
F
T
K
--
D
-
A
-
K
---
A
F
-------
G
I
S
G
E
V
T
F
D
Y
G
I
A
Y
D
R
S
----
R
K
V
A
E
G
R
V
A
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
-
F
A
D
A
N
T
L
--
L
V
DLNDG
G
-----------
T
--
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
-
T
R
L
--
V
P
G
--
T
S
L
---
S
A
N
----
V
V
T
Y
E
E
Q
I
L
S
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
-
N
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
-
L
G
V
T
I
L
--
T
A
T
K
V
E
S
I
A
D
G
G
S
---
Q
--
V
T
V
-------
T
--
V
-----
T
-----
K
DG
V
-
A
---
Q
----
E
--
L
-
K
---
A
E
K
V
L
Q
A
I
-----
G
F
A
P
N
V
E
--
G
Y
G
L
D
K
A
-
G
-
V
-
A
-
L
T
D
-
R
-
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
-
N
G
L
-
L
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
-----
M
-
L
--
P
R
A
T
----
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
F
-----
18
PsiBlast_PDB
82.29
37%
-91
- C3 -
3II4
3
DLDH_MYCTU
A:
[5-464]
-----------------------------------------------------------------------------------------------------------------------------
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-------
K
-------
Y
-
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
----
R
N
A
E
L
--
V
----
H
----
I
F
T
K
--
D
-
A
-
K
---
A
F
-------
G
I
S
G
E
V
T
F
D
Y
G
I
A
Y
D
R
S
----
R
K
V
A
E
G
R
V
A
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
-
F
A
D
A
N
T
L
--
L
V
DLNDG
G
-----------
T
--
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
-
T
R
L
--
V
P
G
--
T
S
L---
S
A
N
----
V
V
T
Y
E
E
Q
I
L
S
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
-
N
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
-
L
G
V
T
I
L
--
T
A
T
K
V
E
S
I
A
D
G
G
S
---
Q
--
V
T
V
-------
T
--
V
-----
T
-----
K
DG
V
-
A
---
Q
----
E
--
L
-
K
---
A
E
K
V
L
Q
A
I
-----
G
F
A
P
N
V
E
--
G
Y
G
L
D
K
A
-
G
-
V
-
A
-
L
T
D
-
R
-
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
-
N
G
L
-
L
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
-----
M
-
L
--
P
R
A
T
----
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
F
-----
88
PsiBlast_CBE
80.40
36%
-98
- C3 -
1LVL
2
DLDH1_PSEPU
A:
[18-457]
------------------------------------------------------------------------------------------------------------------------------------------
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
G
-------
Q
-------
A
-
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
----
H
V
A
E
Q
--
F
----
H
------------
Q
-
A
---
S
R
F
T
E
PSPL
G
I
S
V
A
S
P
-
R
--
L
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
G
V
A
A
L
L
K
K
H
G
V
K
V
V
H
G
W
A
K
-
V
L
D
G
K
Q
V
--
E
V
-----
D
-----------
G
--
Q
R
I
Q
C
E
H
L
L
L
A
T
G
S
--
S
S
V
E
-
L
P
M
--
L
------
P
L
GGP-
V
I
S
S
T
E
A
L
A
P
K
-
A
-
L
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
-
T
Y
D
S
E
L
T
A
P
V
A
E
S
L
K
K
-
L
G
I
A
L
H
------
L
G
H
S
V
E
G
Y
E
---
N
--
G
C
L
-------
L
--
A
-----
N
-----
D
----
G
---
K
G
G
Q
L
R
--
L
-
E
---
A
D
R
V
L
V
A
V
-----
G
R
R
P
R
T
K
--
G
F
-
N
L
E
C
L
D
-
L
-
K
-
M
-
N
-
G
-
A
A
I
A
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
V
-
A
G
E
-
P
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
I
I
A
G
------
K
A
R
R
-----
F
-
E
--
P
A
A
I
A
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
L
D
C
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
T
L
G
E
A
V
Q
E
A
A
L
R
A
L
G
H
A
L
H
I
-----
86
PsiBlast_CBE
80.11
37%
-83
- C3 -
2QAE
2
DLDH_TRYCR
B:
[17-467]
--------------------------------------------------------------------------------------------------------------------------------------------
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
-------
R
G------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
----
H
A
T
H
L
--
Y
----
H
----
D
A
-
H
--
A
-
N
-
F
---
A
R
-------
Y
G
L
M
G
G
E
-
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
-
F
E
T
A
H
S
I
--
R
V
-----
N
GLDGK------
Q
--
E
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
-
F
L
P
--
F
D
----
E
K
V
----
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
-
T
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
E
K
M
K
F
M
--
T
S
T
K
V
V
G
G
T
N
N
G
D
---
S
--
V
S
L
-------
E
--
V
EG---------------KR-
E
----
T
--
V
-
T
---
C
E
A
L
L
V
S
V
-----
G
R
R
P
F
T
G
--
G
L
G
L
D
K
I
-
N
-
V
A
K
-
N
-
E
-
R
-
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
-
P
M
L
A
H
K
A
E
D
E
G
-
V
A
C
A
E
I
L
A
------
G
K
P
G
H
V
N
Y
G
V
-
I
--
P
A
V
I
----
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
F
-----
87
PsiBlast_CBE
78.83
37%
-83
- C3 -
2QAE
2
DLDH_TRYCR
A:
[17-467]
--------------------------------------------------------------------------------------------------------------------------------------------
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
-------
R
G------
A
-
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
----
H
A
T
H
L
--
Y
----
H
----
D
A
-
H
--
A
-
N
-
F
---
A
R
-------
Y
G
L
M
G
G
E
-
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
-
F
E
T
A
H
S
I
--
R
V
-----
N
GLDG
K
------
Q
--
E
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
-
F
L
P
--
F
D
----
E
K
V
----
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
-
T
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
E
K
M
K
F
M
--
T
S
T
K
V
V
G
G
T
N
N
G
D
---
S
--
V
S
L
-------
E
--
V
E
G---------------K
R
-
E
----
T
--
V
-
T
---
C
E
A
L
L
V
S
V
-----
G
R
R
P
F
T
G
--
G
L
G
L
D
K
I
-
N
-
V
A
K
-
N
-
E
-
R
-
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
-
P
M
L
A
H
K
A
E
D
E
G
-
V
A
C
A
E
I
L
A
------
G
K
P
G
H
V
N
Y
G
V
-
I
--
P
A
V
I
----
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
F
-----