@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0933: (2015-12-04 )
MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVVGDNKSQLVKSVGRIAELQAKVGDSVSGTTGIGHTRWATHGKPTEGNAHPHTSGSGRFVLVHNGVIENYLQIKETYLTKHNLKGETDTEIAIHLVEHFVEEDNLSVLEAFKKALHIIEGSYAFALIDSQDADTIYVAKNKSPLLIGLGNGYNMVCSDAMAMIRETSEYMEIHDKELVIVKKDSVEVQDYDGNVIERGSYTAELDLSDIGKGTYPFYMLKEIDEQPTVMRKLISTYANESGDMNVDSDIIKSVQEADRLYILAAGTSYHAGFAAKTMIEKLTDTPVELGVSSEWGYNMPLLSKKPMFILLSQSGETADSRQVLVKANEMGIPSLTITNVPGSTLSREATYTMLIHAGPEIAVASTKAYTAQVATLAFLAKAVGEANGKAEAKDFDLVHELSIVAQSIEATLSEKDVISEKVEQLLISTRNAFYIGRGNDYYVTMEAALKLKEISYIQTEGFAAGELKHGTISLIEDNTPVIALISADSTIAAHTRGNIQEVVSRGANALIIVEEGLEREGDDIIVNKVHPFLSAISMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE
Atome Classification :
(28 SA)
.........10........20........30......-..40........50...-.....60........70........80........90........100.......110...-....120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260---........270...----.-----...280--------.-.......290.......300.......310.......320.......-330.......340-----.......350.......360...-.-...370.......380.......390.......400.......410.......420.......430.......440.......450-........460.......470.......480.......490.......500.......510.......-520.......530.......540......----.550-...--....----..560--.-....---------....570.......580.......590.......600..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MC
G
I
V
G
VVGNT
N
A
T
D
I
L
I
Q
G
L
E
K
L
EYRGYDS
A
G
I
F
V
V-GD
N
K
S
Q
L
V
K
S
V
G
R
I
A
E
L
-
Q
A
KVGDSVSGTTGIGHTRWATHGKPTEGNAHPHTSGS
G
R
F
V
L
V
HN
G
V
I
E
N
Y
L
Q
I
K
E
T
Y
L
T
K-HNLKGET
D
T
E
I
A
I
H
L
V
E
H
F
V
EED
N
L
S
V
L
E
A
F
K
K
A
L
H
IIEG
S
Y
A
F
A
L
IDSQDA
D
T
I
Y
V
AKNKS
P
L
L
I
G
LGNGYN
M
V
C
S
D
A
M
A
M
I
R
E
T
S
E
Y
M
E
IHD
K
E
L
V
I
V
KKD
S
V
E
V
QDYDG
N
V
IERGS
Y
T
A
E
L
D
L
S
DIGKGTY
P
F
Y
M
L
K
EIDEQ
P
----
T
V
M
R
K
L
I
S
T
YANES----G-----DMNV
D
---------
S
-
D
I
I
K
S
V
Q
EAD
R
L
Y
I
L
AAGTSYHA
G
F
A
A
K
T
M
I
E
K
LTDTP
V
E
LGVSSEW-GYNMPLLSKK
P
M
F
-----
I
L
LSQSGETADS
R
Q
V
L
V
K
ANEMG-I-
P
S
L
T
I
TNVPGSTLSRE
A
T
Y
T
M
L
I
HAGP
E
I
A
V
A
STK
A
Y
T
A
Q
V
A
T
L
A
F
L
A
K
A
V
GEANGKAEA
K
D
F
D
L
V
H
E
L
S
I
V
A
Q
S
I
E
A
T
LSE
K
D
V
--
I
S
E
K
V
E
Q
L
L
I
STR
N
A
F
Y
I
GRG
N
D
Y
Y
V
T
M
E
A
A
L
K
L
K
E
I
S
Y
I
QTEGFAAGELKH
G
T
I
S
L
IEDNT
P
V
I
A
L
I
-SAD
S
T
I
A
AHTRG
N
I
Q
E
V
V
S
RGA
N
A
L
I
I
VE----EG---LER--EGD
D
----
I
I
V
----
N
-
K
V
H
P
---------
F
L
S
A
I
S
M
V
I
P
T
Q
L
I
A
Y
Y
A
S
L
Q
RGLDVDKPRN
L
A
K
A
VTVE
2
PsiBlast_PDB
94.93
37%
-83
- C1 -
4AMV
1
GLMS_ECOLI
A:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
NMHI
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
4
PsiBlast_PDB
94.33
36%
-84
- C1 -
2J6H
3
GLMS_ECOLI
A:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
N
M
H
I
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
21
PsiBlast_CBE
94.31
37%
-84
- C1 -
4AMV
2
GLMS_ECOLI
C:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
NMHI
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
22
PsiBlast_CBE
93.59
37%
-85
- C1 -
4AMV
2
GLMS_ECOLI
B:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
NMHI
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
30
PsiBlast_CBE
93.32
36%
-88
- C1 -
3OOJ
7
GLMS_ECOLI
D:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
------
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVD
L
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
NMHI
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
25
PsiBlast_CBE
92.92
36%
-84
- C1 -
2J6H
3
GLMS_ECOLI
B:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
NMHI
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
27
PsiBlast_CBE
92.89
36%
-90
- C1 -
3OOJ
14
GLMS_ECOLI
G:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
---
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
NMHI
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
29
PsiBlast_CBE
92.82
36%
-86
- C1 -
3OOJ
2
GLMS_ECOLI
E:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
N
M
HI
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
28
PsiBlast_CBE
92.22
36%
-89
- C1 -
3OOJ
1
GLMS_ECOLI
F:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
--------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
NMHI
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
26
PsiBlast_CBE
92.01
36%
-85
- C1 -
3OOJ
14
GLMS_ECOLI
H:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
NMHI
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
7
PsiBlast_PDB
91.53
36%
-85
- C1 -
3OOJ
7
GLMS_ECOLI
A:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
NMHI
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
32
PsiBlast_CBE
91.51
36%
-85
- C1 -
3OOJ
7
GLMS_ECOLI
B:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVD
L
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
NMHI
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
31
PsiBlast_CBE
90.98
36%
-85
- C1 -
3OOJ
7
GLMS_ECOLI
C:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
-------
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
NM
H
I
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
24
PsiBlast_CBE
89.23
36%
-81
- C1 -
1JXA
1
GLMS_ECOLI
B:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
NMHI
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
3
PsiBlast_PDB
89.20
36%
-82
- C1 -
1JXA
1
GLMS_ECOLI
A:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
N
M
H
I
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
23
PsiBlast_CBE
87.74
36%
-83
- C1 -
1JXA
1
GLMS_ECOLI
C:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
-
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
NMHI
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
1
PsiBlast_PDB
79.04
57%
-96
- C1 -
4S1W
2
?
A:
[5-342]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
A
H
Y
M
L
K
E
I
H
E
Q
P
----
A
V
M
R
R
I
I
Q
E
Y
Q
D
A
E
----
G
-----
N
L
K
I
D
---------
Q
-
D
I
I
N
D
V
K
E
A
D
R
I
Y
V
I
A
A
G
T
S
Y
H
A
G
L
V
G
K
E
F
L
E
K
W
A
G
V
P
T
E
V
H
V
A
S
E
F
-
V
Y
N
M
P
L
L
S
E
K
P
L
F
-----
V
Y
I
S
Q
S
G
E
T
A
D
S
R
A
V
L
V
E
T
N
K
L
G
-
H
-
K
S
L
T
I
T
N
V
A
G
S
T
L
S
R
E
A
D
H
T
L
L
L
H
A
G
P
E
I
A
V
A
S
T
K
A
Y
T
A
Q
I
A
V
L
S
I
L
S
Q
I
V
A
K
E
H
---
E
A
-
D
I
D
L
L
R
E
L
A
K
V
T
T
A
I
E
A
I
V
D
D
A
P
I
--
M
E
Q
I
A
T
D
F
L
E
T
T
R
N
A
F
F
I
G
R
T
I
D
Y
N
V
S
L
E
G
A
L
K
L
K
E
I
S
Y
I
Q
A
E
G
F
A
G
G
E
L
K
H
G
T
I
A
L
I
E
D
G
T
P
V
V
A
L
A
-
T
Q
E
N
-
V
N
L
S
I
R
G
N
V
K
E
V
V
A
R
G
A
H
P
C
I
I
S
M
----
E
G
---
L
E
K
--
E
G
D
T
----
Y
V
I
----
P
-
H
V
H
E
---------
L
L
T
P
L
V
S
V
V
A
L
Q
L
I
S
Y
Y
A
A
L
H
R
D
----------------
59
HHSearch
69.58
37%
-77
* C1 *
2ZJ3
1
GFPT1_HUMAN
A:
[11-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
----
E
S
V
V
N
T
M
R
G
R
V
N
F
D
----
D
YTVNL
G
G
L
-----------
K
-
D
H
I
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
-
L
D
R
N
T
P
V
F
R
D
D
V
C
-----
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
-
A
-
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
--
I
Q
K
L
A
T
-
E
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
-
M
R
D
H
-
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
----
K
E
---
D
T
E
T
I
K
N
T
K
----
R
T
I
K
---
V
P
H
S
V
D
---------
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
6
PsiBlast_PDB
68.21
36%
-76
- C1 -
2VF5
1
GLMS_ECOLI
X:
[243-608]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
NMHI
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
9
PsiBlast_PDB
67.88
36%
-77
- C1 -
1MOQ
9
GLMS_ECOLI
A:
[5-368]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
N
M
H
I
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
65
HHSearch
67.71
37%
-78
- C1 -
1MOQ
9
GLMS_ECOLI
A:
[4-368]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVD-
L
-----
S
E
L
-----------
G
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
-
Y
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
E
A
L
A
E
-
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
-
P
N
N
E
-
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
V
S
S
D
N
M
----
H
I
I
E---
M
P
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
8
PsiBlast_PDB
67.46
36%
-76
- C1 -
1MOS
6
GLMS_ECOLI
A:
[5-368]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
N
M
H
I
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
12
PsiBlast_PDB
66.85
38%
-70
- C1 -
2ZJ4
1
GFPT1_HUMAN
A:
[11-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
----
E
------
S
V
V
N
T
M
R
----
G
-----
R
V
N
F
D
DYTVNLGGL
K
-
D
H
I
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
N
T
P
V
F
R
D
D
V
C
F
------
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
-
A
-
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
--
I
-
Q
K
L
A
T
E
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
-
M
R
D
H
T
Y
A
K
-
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
KED
T
E
T
---
I
K
N
--
T
K
R
T
----
I
K
V
----
P
-
H
S
V
D
---------
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
10
PsiBlast_PDB
66.85
36%
-74
- C1 -
1MOR
1
GLMS_ECOLI
A:
[5-368]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
----
N
A
I
K
N
T
L
T
G
R
I
S
H
G
QVDL
S
-----
E
L
G
P
N
---------
A
-
D
E
L
L
S
--
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
-
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
--
I
-
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
-
V
V
-
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
---
A
G
F
--
V
S
S
D
N
M
H
I
I
E
M
----
P
-
H
V
E
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
11
PsiBlast_PDB
66.75
38%
-71
- C1 -
2ZJ3
1
GFPT1_HUMAN
A:
[11-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
----
E
------
S
V
V
N
T
M
R
----
G
-----
R
V
N
F
D
DYTVNLGGL
K
-
D
H
I
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
N
T
P
V
F
R
D
D
V
C
F
------
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
-
A
-
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
--
I
-
Q
K
L
A
T
E
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
-
M
R
D
H
T
Y
A
K
-
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
KED
T
E
T
---
I
K
N
--
T
K
R
T
----
I
K
V
----
P
-
H
S
V
D
---------
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
18
PsiBlast_PDB
62.48
35%
-84
- C1 -
2PUW
3
GFA1_CANAL
A:
[4-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
D
S
A
F
N
T
M
R
G
R
I
D
-
F
E
N
C
V
----
V
-----
T
L
G
G
L
---------
K
-
S
W
L
S
T
I
R
R
C
R
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
L
T
E
I
P
V
S
V
E
L
A
S
D
F
------
L
D
R
R
S
P
V
F
RD
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
G
-
A
-
L
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
D
S
I
S
R
K
G
R
H
E
E
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
K
--
I
K
D
L
C
N
S
S
---
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
---------
E
D
L
P
I
I
A
F
A
-
T
R
D
S
-
L
F
P
K
V
M
S
A
I
E
Q
V
T
A
R
D
G
R
P
I
V
I
C
N
--------------
E
G
D
A
----
I
I
S
----
N
D
K
V
H
T
T
L
E
V
P
E
T
VD
C
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
------------
36
PsiBlast_CBE
61.06
35%
-80
- C1 -
2PUW
2
GFA1_CANAL
B:
[4-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
D
S
A
F
N
T
M
R
G
R
I
D
-
F
E
N
C
V
----
V
-----
T
L
G
G
L
---------
K
-
S
W
L
S
T
I
R
R
C
R
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
L
T
E
I
P
V
S
V
E
L
A
S
D
F
------
L
D
R
R
S
P
V
F
RD
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
G
-
A
-
L
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
D
S
I
S
R
K
G
R
H
E
E
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
K
--
I
K
D
L
C
N
S
S
---
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
-----------
L
P
I
I
A
F
A
-
T
R
D
S
-
L
F
P
K
V
M
S
A
I
E
Q
V
T
A
R
D
G
R
P
I
V
I
C
N
--------------
E
G
D
---------------
V
H
T
T
L
E
V
P
E
TVD
C
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
------------
55
Fugue
40.77
36%
-69
- C1 -
1MOQ
7
?
?:
[186-368]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
------
K
R
I
E
-
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
--
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
----
Q
D
AG
F
V
S
S
--
D
N
M
H
----
I
I
E
MPHV
E
----
E
---------
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E