@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1023: (2015-12-04 )
MTQPILQVSDLSVYYNKKKALKEVSMDFYPNEITALIGPSGSGKSTLLRAINRMGDLNPEVTLTGAVMYNGHNVYSPRTDTVELRKEIGMVFQQPNPFPMSVFENVVYGLRLKGIKDKATLDEAVETSLKGASIWDEVKDRLHDSALGLSGGQQQRVCIARTLATKPKIILLDEPTSALDPISAGKIEETLHGLKDQYTMLLVTRSMQQASRISDRTGFFLDGNLIEYGNTKEMFMNPKHKETEDYITGKFG
Atome Classification :
(33 SA)
.........10........20........30........40........50........60........70.......-----------.80...-----------.....90........-100........------110.......120.......130......--.140......-.150.......160.......170.......180.......190..--.-..-..200.......210.......220.......230.......240.......250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTQP
I
L
Q
VS
D
L
S
V
Y
Y
N
K
K
K
A
L
K
E
V
S
MDFYPN
E
I
T
A
L
IGPSGS
G
K
S
T
L
L
R
A
I
N
R
MGDLNP
E
V
T
L
T
G
A
V
M
YNGHNVYSPR-----------T
D
T
V
E
L
-----------
R
K
E
I
G
M
VFQQPNPF
P
-
M
-
S
V
F
E
N
V
V
Y
G
------
L
R
LKGIKDK
A
T
L
D
E
A
V
E
T
SLKGA
S
I
W
D
E
V
--
K
D
R
L
H
D
SALG-LSGGQQ
Q
R
V
C
I
A
RTLATK
P
K
I
I
L
L
DEPTSALDPISA
G
K
I
E
E
T
L
H
G
L
--
K
-
D
Q
-
Y
T
M
L
L
V
T
R
S
M
Q
Q
A
S
RISDRT
G
F
F
LDG
N
L
IEYG
N
T
K
E
MFMNPKHKETEDYITGKFG
1
PsiBlast_PDB
94.54
39%
-95
- C1 -
4U00
3
?
A:
[3-238]
---
P
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
-----
E
G
E
V
V
V
D
G
L
S
V
K
D
D
R
-----------
A
-
L
R
E
I
-----------
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
-
T
V
L
E
N
V
T
L
A
P
-----
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
-
L
E
R
V
G
I
L
D
Q
A
--
R
K
----
Y
P
A
Q
-
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
-
G
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
23
PsiBlast_CBE
92.82
39%
-90
- C1 -
4U02
1
?
B:
[2-238]
--
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
-----
E
G
E
V
V
V
D
G
L
S
V
K
D
D
R
-----------
A
-
L
R
E
I
-----------
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
-
T
V
L
E
N
V
T
L
A
P-----
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
-
L
E
R
V
G
I
L
D
Q
A
--
R
K
----
Y
P
A
Q
-
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A-
Q
-
G
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
2
PsiBlast_PDB
92.49
39%
-91
- C1 -
4U02
1
?
A:
[2-238]
--
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
-----
E
G
E
V
V
V
D
G
L
S
V
K
D
D
R
-----------
A
-
L
R
E
I
-----------
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
-
T
V
L
E
N
V
T
L
A
P-----
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
-
L
E
R
V
G
I
L
D
Q
A
--
R
K
----
Y
P
A
Q
-
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
-
G
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
22
PsiBlast_CBE
91.76
39%
-90
- C1 -
4U02
1
?
C:
[2-238]
--
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
-----
E
G
E
V
V
V
D
G
L
S
V
K
D
D
R
-----------
A
-
L
R
E
I
-----------
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
-
T
V
L
E
N
V
T
L
A
P-----
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
-
L
E
R
V
G
I
L
D
Q
A
--
R
K
----
Y
P
A
Q
-
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A-
Q
-
G
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
21
PsiBlast_CBE
91.22
39%
-89
- C1 -
4U02
1
?
D:
[2-238]
--
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
-----
E
G
E
V
V
V
D
G
L
S
V
K
D
D
R
-----------
A
-
L
R
E
I
-----------
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
-
T
V
L
E
N
V
T
L
A
P-----
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
-
L
E
R
V
G
I
L
D
Q
A
--
R
K
----
Y
P
A
Q
-
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A-
Q
-
G
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
3
PsiBlast_PDB
88.33
36%
-81
- C1 -
2OLJ
4
?
A:
[24-263]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
116
HHSearch
88.00
36%
-86
- C1 -
1B0U
4
HISP_SALTY
A:
[5-257]
---
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
-----
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
L
-----------
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
-
T
V
L
E
N
V
M
E
A
------
P
I
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
-----
Q
G
K
Y
P
V
H
-
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
--
A
E
E
G
-
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
24
PsiBlast_CBE
87.98
36%
-84
- C1 -
3C4J
4
?
B:
[24-263]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
30
PsiBlast_CBE
87.91
36%
-77
- C1 -
2OLK
1
?
C:
[24-263]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
29
PsiBlast_CBE
87.90
36%
-79
- C1 -
2OLK
1
?
D:
[24-263]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
4
PsiBlast_PDB
87.67
36%
-79
- C1 -
2OLK
1
?
A:
[24-263]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
5
PsiBlast_PDB
87.43
36%
-79
- C1 -
2OUK
1
?
A:
[24-263]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
27
PsiBlast_CBE
87.07
36%
-78
- C1 -
2OUK
1
?
C:
[24-263]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
28
PsiBlast_CBE
86.81
36%
-80
- C1 -
2OUK
2
?
B:
[24-263]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
33
PsiBlast_CBE
86.67
36%
-77
- C1 -
3C41
3
?
K:
[3-242]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
32
PsiBlast_CBE
86.60
36%
-80
- C1 -
2OLJ
3
?
B:
[24-263]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
8
PsiBlast_PDB
86.34
36%
-74
- C1 -
3C41
3
?
J:
[3-242]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
31
PsiBlast_CBE
86.25
36%
-79
- C1 -
2OLK
2
?
B:
[24-263]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
7
PsiBlast_PDB
86.21
36%
-78
- C1 -
3C4J
3
?
A:
[24-263]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
47
PsiBlast_CBE
86.19
33%
-86
- C1 -
1B0U
4
HISP_SALTY
A:
[5-257]
---
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
-----
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
-----------
D
K
D
G
Q
L
KVAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
-
T
V
L
E
N
V
M
E
A
P-----
I
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
-
L
A
K
V
G
I
D
E
R
A
--
Q
G
K
Y
---
P
V
H
-
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
--
A
-
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
6
PsiBlast_PDB
85.92
36%
-74
- C1 -
2Q0H
4
?
A:
[24-263]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
25
PsiBlast_CBE
85.59
36%
-80
- C1 -
2Q0H
4
?
B:
[24-263]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
-----------
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
-
T
V
L
N
N
I
T
----------
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
--
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-
11
PsiBlast_PDB
79.57
34%
-77
- C1 -
4YMU
2
?
J:
[4-237]
-------
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
-----
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-----------
V
N
I
N
K
V
-----------
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
-
T
A
I
E
N
I
T
L
A
P-----
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-------
D
K
K
D
Q
Y
P
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-
12
PsiBlast_PDB
79.10
34%
-76
- C1 -
4YMV
1
?
J:
[4-237]
-------
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
-----
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-----------
V
N
I
N
K
V
-----------
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
-
T
A
I
E
N
I
T
L
A
P-----
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-------
D
K
K
D
Q
Y
P
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-
34
PsiBlast_CBE
78.54
34%
-75
- C1 -
4YMV
1
?
A:
[4-237]
-------
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
-----
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-----------
V
N
I
N
K
V
-----------
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
-
T
A
I
E
N
I
T
L
A
P-----
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-------
D
K
K
D
Q
Y
P
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-
35
PsiBlast_CBE
78.20
34%
-75
- C1 -
4YMU
2
?
A:
[4-237]
-------
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
-----
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-----------
V
N
I
N
K
V
-----------
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
-
T
A
I
E
N
I
T
L
A
P-----
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
-------
D
K
K
D
Q
Y
P
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-
73
PsiBlast_CBE
67.07
36%
-79
- C1 -
1L2T
4
Y796_METJA
B:
[20-223]
-------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
---
N
I
I
G
C
L
D
K
P
T
E
--
G
E
V
Y
I
D
--
N
I
K
T
N
D
-----------
L
D
D
D
E
L
TKIR-------
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
-
L
L
T
A
L
E
N
V
E
L
P
------
L
I
F
K
-
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
-
E
L
--
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
NE
E
-
D
G
-
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
G
F
------------------
74
PsiBlast_CBE
66.23
36%
-77
- C1 -
1L2T
4
Y796_METJA
A:
[20-223]
-------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
---
N
I
I
G
C
L
D
K
P
T
E
--
G
E
V
Y
I
D
--
N
I
K
T
N
D
-----------
L
D
D
D
E
L
T
K
I
R
-------
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
-
L
L
T
A
L
E
N
V
E
L
P
------
L
I
F
K
-
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
-
E
L
--
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
-
D
G
-
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
--------------------
75
PsiBlast_CBE
66.21
36%
-80
- C1 -
3TIF
6
Y796_METJA
B:
[20-223]
-------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
---
N
I
I
G
C
L
D
K
P
T
E
--
G
E
V
Y
I
D
--
N
I
K
T
N
D
-----------
L
D
D
D
E
L
TKIR-------
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
-
L
L
T
A
L
E
N
V
E
L
P
------
L
I
F
K
-
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
-
E
L
--
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
NE
E
-
D
G
-
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
G
F
------------------
76
PsiBlast_CBE
65.57
36%
-75
- C1 -
3TIF
7
Y796_METJA
A:
[20-223]
-------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
---
N
I
I
G
C
L
D
K
P
T
E
--
G
E
V
Y
I
D
--
N
I
K
T
N
D
-----------
L
D
D
D
E
L
T
K
I
R
-------
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
-
L
L
T
A
L
E
N
V
E
L
P
------
L
I
F
K
-
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
-
E
L
--
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
-
D
G
-
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
--------------------
54
PsiBlast_CBE
57.05
32%
-67
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[391-598]
--------------------
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
-----
P
A
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
-----------
L
N
P
V
W
L
-----------
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
-
C
-
S
I
A
E
N
I
A
Y
G
ADDPSS
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
-----
V
G
E
K
G
V
L
-
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
-
D
G
-
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-------------------
51
PsiBlast_CBE
56.02
32%
-60
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[360-572]
--------------------
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
-----
P
A
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
-----------
L
N
P
V
W
L
-----------
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
-
C
-
S
I
A
E
N
I
A
Y
G
ADDPSS
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
-----
V
G
E
K
G
V
L
-
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
-
D
G
-
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
G
------------
52
PsiBlast_CBE
55.91
32%
-64
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[360-567]
--------------------
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
-----
P
A
S
G
T
I
S
L
D
G
H
D
I
R
--
Q
-----------
L
N
P
V
W
L
-----------
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
-
C
-
S
I
A
E
N
I
A
Y
G
ADDPSS
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
-----
V
G
E
K
G
V
L
-
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
-
D
G
-
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-------------------