@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1040: (2015-12-05 )
MATTTKTSTKKTNKKKSATAKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLINDLKKEAKKAKKVYLASDPDREGEAISWHLAHILDLDKEDRNRVVFNEITKDAVKNAFVEPRQINMDLVDAQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFQPEEYWTIDGSFKKGTRKFNATFYGLDGKKFKLSNNEDVKTVLKRIKTDEFLVEKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMIAQQLYEGLSLGTAGHQGLITYMRTDSTRISPLAQNEATEFITNRFGANYSKHGNKVKNASGAQDAHEAIRPSSVNHTPESIAKYLDKDQLKLYTLIWNRFIASQMTAAVFDTMKVNLTQNGVTFIANGSQVKFDGYMAVYNDTDKNKMLPDMEEGESVKKVNTNPEQHFTQPPARFSEASLIKTLEENGVGRPSTYAPTLETIQKRYYVKLAAKRFEPTELGEIVNSLIVEFFPDIVDVTFTAEMEGKLDEVEIGNEQWQKIIDEFYKPFEKELAKAETEMEKIQIKDEPAGFDCELCGSPMVIKLGRYGKFYACSNFPECHNTKAITKEIGVICPICQKGQVIERKTKRNRIFYGCDRYPECEFTSWDKPIGRTCPKSNDFLVEKKVRGGGKQVVCSNEKCDYQEEKIK
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40-------------------.....------------...50-----------......----...60--------..-----..-...-.-.70---..-------------------------.-------------------------....-.80........90........100.......110.......120.......130.......140.......150.......160.......170.....-.-.180.......190.......200.......210.......220....-.-...230.......240.-......250.......260.......270.......280.......290.......300.......310.......320.......330.......340...--....350........360.......---------370-----.........380.......390.......400.......410.....--..420.....--.--.430---.......440-.-......----450.......460.......470.......480.......490.......500...-..-..510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.-......630.......640.......650.......660.......670.......680.......690.......700....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATTTKTSTKKTNKKKSATAKK
N
L
V
I
V
ESPAK
A
K
T
I
E
K
Y
LG-------------------RN
Y
K
V
------------
V
A
SV------------
G
H
I
R
D
L
----
K
K
SS---------
M
S
-----
I
D-FEN-N-YEP---
Q
Y
-------------------------
I
-------------------------
N
I
RG-KGP
L
I
N
D
L
K
K
E
A
K
KA
K
K
V
Y
LASDPDREG
E
A
I
S
W
H
L
A
H
I
LDLDKEDRNR
V
V
F
N
E
I
T
K
D
A
V
K
NAFVEPRQINMDLV
D
A
Q
Q
A
R
R
V
L
D
R
I
VGYSI
S
P
I
L
W
K
K
V
-
K
-KGLSAG
R
V
Q
S
V
A
L
K
L
I
IDRENEIKAFQPE
E
Y
W
T
IDGSFKKG
T
R
-
K
F
N
A
-
T
-
F
YGLDG
K
K
F
KLSN
N
E
D
V
-
K
T
V
L
K
R
IKT
D
E
F
L
V
E
K
V
E
K
K
E
R
RRNAPLPYT
T
S
S
L
Q
Q
D
A
ANKINF
R
T
R
K
T
M
M
I
A
Q
Q
L
YEGLSLGTAGHQ
G
L
I
T
Y
M
RTDSTRISPLA
Q
N
E
A
T
E
F
I
T
N
RFGANY--SKHGN-KVKNASG
A
Q
D
A
H
E
AIRPSS---------V-------NH
T
P
E
S
I
A
K
Y
L
D
K
D
Q
L
K
L
Y
T
L
I
W
N
R
F
I
A
S
Q
M
T
A
A
V
F
D
T
M
K
V
N
LTQN
G
--
V
T
F
I
ANG
S
Q
V
--
K
--FD
G
Y
---
M
A
V
YNDTDKN-K-MLPDME----EGESVKKVNTN
P
E
QHFTQPPARF
S
E
A
S
L
I
K
T
L
E
ENGVGRPSTYA
P
T
L
E
T
I
Q
K
R
Y
Y
V
-
K
L
-
A
A
KRF
E
P
T
E
L
G
E
I
V
N
S
L
I
V
E
FFPDI
V
D
V
T
F
T
A
E
MEGKLD
E
V
EIG
N
E
Q
W
Q
K
I
I
D
E
F
Y
K
P
F
E
K
E
L
A
K
A
ETEM
E
K
I
Q
IKDEPAGFDCELCGS
P
M
V
I
K
LGRYG
K
F
Y
A
CSNFPECHN
T
K
A
I
-
T
K
EI
G
V
ICPICQKG
Q
V
I
E
R
KTKRN
R
I
F
YGCDRYPECEFTSWDKPIGRTCPKSND
F
L
V
E
K
KVRGGG
K
Q
V
V
CSNEKCDY
Q
E
EKIK
24
HHSearch
93.79
45%
-57
- C2 -
1MW9
9
TOP1_ECOLI
X:
[2-581]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
-------------------
S
D
Y
V
V
------------
K
S
S
V
------------
G
H
I
R
D
L
----
P
T
-------------ERGAL
V
N
R
M
G
V
D
P
-
W
H
N
WEA
H
Y
-------------------------
E
-------------------------
V
L
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
E
A
L
A
L
-
Q
-
V
T
H
Q
N
D
K
P
F
R
P
V
-
N
K
E
Q
T
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
--
L
P
E
S
P
N
Q
Y
A
--------
R
E
A
I
R
P
S
D
---------
V
-------
N
V
M
A
E
S
L
K
D
-
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
---
T
K
V
M
P
A
L
---E
D
R
I
L
P
A
V
N
----
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
-
R
V
-
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
92.16
43%
-65
- C2 -
1CY4
4
TOP1_ECOLI
A:
[5-586]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
-------------------
S
D
Y
V
V
------------
K
S
S
V
------------
G
H
I
R
D
L
P
T------DER
G
A
L
V
N
R
M
G
-----
V
D
-
P
W
H
-
N
-
W
E
A
---
H
Y
-------------------------
E
-------------------------
V
L
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
A
L
A
L
Q
-
V
T
H
Q
N
D
K
P
F
R
P
V
N
K
E
Q
T
-
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L-
P
E
S
P
N
-
Q
Y
A
--------
H
E
A
I
R
P
S
D
---------
V
-------
N
V
M
A
E
S
L
-
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
TKV
M
P
A
L
---------
I
L
P
A
V
N
----
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
-
R
V
-
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
V
L
T
S
--------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.81
43%
-60
- C2 -
1CY8
3
TOP1_ECOLI
A:
[5-586]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
-------------------
S
D
Y
V
V
------------
K
S
S
V
------------
G
H
I
R
D
L
P-------DER
G
A
L
V
N
R
M
G
-----
V
D
-
P
W
H
-
N
-
W
E
A
---
H
Y
-------------------------
E
-------------------------
V
L
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
A
L
A
L
Q
-
V
T
H
Q
N
D
K
P
F
R
P
V
N
K
E
Q
T
-
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L-
P
E
S
P
N
-
Q
Y
A
--------
H
E
A
I
R
P
S
D
---------
V
-------
N
V
M
A
E
S
L
-
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
TKV
M
P
A
L
R
K
G
D
E
D
-
R
-
I
L
P
A
V
N
----
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
-
R
V
-
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
V
L
T
---------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
91.62
43%
-66
- C2 -
1CY6
4
TOP1_ECOLI
A:
[5-586]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
-------------------
S
D
Y
V
V
------------
K
S
S
V
------------
G
H
I
R
D
L
PT------DER
G
A
L
V
N
R
M
G
-----
V
D
-
P
W
H
-
N
-
W
E
A
---
H
Y
-------------------------
E
-------------------------
V
L
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
A
L
A
L
Q
-
V
T
H
Q
N
D
K
P
F
R
P
V
N
K
E
Q
T
-
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L-
P
E
S
P
N
-
Q
Y
A
-------
A
H
E
A
I
R
P
S
D
---------
V
-------
N
V
M
A
E
S
L
-
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
TKV
M
P
A
L
R
---
E
D
-
R
-
I
L
P
A
V
N
----
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
-
R
V
-
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
V
L
T
---------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
91.61
42%
-68
- C2 -
3PX7
3
TOP1_ECOLI
A:
[3-584]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
-------------------
S
D
Y
V
V
------------
K
S
S
V
------------
G
H
I
R
D
L
P-------DER
G
A
L
V
N
R
M
G
-----
V
D
-
P
W
H
-
N
-
W
E
A
---
H
Y
-------------------------
E
-------------------------
V
L
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
N
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
A
L
A
L
Q
-
V
T
H
Q
N
D
K
P
F
R
P
V
N
K
E
Q
T
-
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L-
P
E
S
P
N
-
Q
Y
A
--------
H
E
A
I
R
P
S
D
---------
V
-------
N
V
M
A
E
S
L
-
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
TKV
M
P
A
L
R
--------
I
L
P
A
V
N
----
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
-
R
V
-
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
--------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
91.30
42%
-58
- C2 -
1MW9
9
TOP1_ECOLI
X:
[3-584]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
-------------------
S
D
Y
V
V
------------
K
S
S
V
------------
G
H
I
R
D
L
PT------ERGALVNR-
M
G
-----
V
D
-
P
W
H
-
N
-
W
E
A
---
H
Y
-------------------------
E
-------------------------
V
L
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
A
L
A
L
Q
-
V
T
H
Q
N
D
K
P
F
R
P
V
N
K
E
Q
T
-
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L-
P
E
S
P
N
-
Q
Y
A
--------
R
E
A
I
R
P
S
D
---------
V
-------
N
V
M
A
E
S
L
-
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
TKV
M
P
A
L
----
E
D
-
R
-
I
L
P
A
V
N
----
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
-
R
V
-
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
91.14
42%
-58
- C2 -
1MW8
7
TOP1_ECOLI
X:
[3-584]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
-------------------
S
D
Y
V
V
------------
K
S
S
V
------------
G
H
I
R
D
L
PTSG----DERGALVNR
M
G
-----
V
D
-
P
W
H
-
N
-
W
E
A
---
H
Y
-------------------------
E
-------------------------
V
L
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
A
L
A
L
Q
-
V
T
H
Q
N
D
K
P
F
R
P
V
N
K
E
Q
T
-
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L-
P
E
S
P
N
-
Q
Y
A
S
-----
E
A
R
E
A
I
R
P
S
D
---------
V
-------
N
V
M
A
E
S
L
-
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
TKV
M
P
A
-----
E
D
-
R
-
I
L
P
A
V
N
----
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
-
R
V
-
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
91.10
42%
-59
- C2 -
3PWT
3
TOP1_ECOLI
A:
[3-584]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
-------------------
S
D
Y
V
V
------------
K
S
S
V
------------
G
H
I
R
D
L
PT------DER
G
A
L
V
N
R
M
G
-----
V
D
-
P
W
H
-
N
-
W
E
A
---
H
Y
-------------------------
E
-------------------------
V
L
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
N
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
A
L
A
L
Q
-
V
T
H
Q
N
D
K
P
F
R
P
V
N
K
E
Q
T
-
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L-
P
E
S
P
N
-
Q
Y
A
-------
A
H
E
A
I
R
P
S
D
---------
V
-------
N
V
M
A
E
S
L
-
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
TKV
M
P
A
L
R
---
E
D
-
R
-
I
L
P
A
V
N
----
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
-
R
V
-
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
V
L
T
---------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.82
43%
-59
- C2 -
1ECL
-
TOP1_ECOLI
A:
[3-584]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
-------------------
S
D
Y
V
V
------------
K
S
S
V
------------
G
H
I
R
D
L
P-------DER
G
A
L
V
N
R
M
G
-----
V
D
-
P
W
H
-
N
-
W
E
A
---
H
Y
-------------------------
E
-------------------------
V
L
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
A
L
A
-
L
Q
V
T
H
Q
N
D
K
P
F
R
P
V
N
K
E
Q
T
-
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L-
P
E
S
P
N
-
Q
Y
A
--------
H
E
A
I
R
P
S
D
---------
V
-------
N
V
M
A
E
S
L
-
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
TKV
M
P
A
L
R
--------
I
L
P
A
V
N
----
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
-
R
V
-
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
--------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.79
43%
-61
- C2 -
1CY1
4
TOP1_ECOLI
A:
[5-586]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
-------------------
S
D
Y
V
V
------------
K
S
S
V
------------
G
H
I
R
D
L
P-------R
G
A
L
V
N
R
--
M
G
-----
V
D
-
P
W
H
-
N
-
W
E
A
---
H
Y
-------------------------
E
-------------------------
V
L
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
A
L
A
L
Q
-
V
T
H
Q
N
D
K
P
F
R
P
V
N
K
E
Q
T
-
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L-
P
E
S
P
N
-
Q
Y
A
------
E
A
H
E
A
I
R
P
S
D
---------
V
-------
N
V
M
A
E
S
L
-
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
TKV
M
P
A
L
---------
I
L
P
A
V
N
----
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
-
R
V
-
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
V
L
T
S
--------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
90.56
43%
-60
- C2 -
1CY0
1
TOP1_ECOLI
A:
[5-574]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
-------------------
S
D
Y
V
V
------------
K
S
S
V
------------
G
H
I
R
D
L
P-------A
L
V
N
R
----
M
G
-----
V
D
-
P
W
H
-
N
-
W
E
A
---
H
Y
-------------------------
E
-------------------------
V
L
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
A
L
A
L
Q
-
V
T
H
Q
N
D
K
P
F
R
P
V
N
K
E
Q
T
-
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L-
P
E
S
P
N
-
Q
Y
A
S
K
E
N
S
Q
E
A
H
E
A
I
R
P
S
D
---------
V
-------
N
V
M
A
E
S
L
-
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
TKV
M
------------
I
L
P
A
V
N
----
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
-
R
V
-
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
--------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.37
43%
-60
- C2 -
1CY2
3
TOP1_ECOLI
A:
[5-586]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
G
-------------------
S
D
Y
V
V
------------
K
S
S
V
------------
G
H
I
R
D
L
P-------DER
G
A
L
V
N
R
M
G
-----
V
D
-
P
W
H
-
N
-
W
E
A
---
H
Y
-------------------------
E
-------------------------
V
L
P
G
-
K
E
K
V
V
S
E
L
K
Q
L
A
E
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
D
D
A
R
Y
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
K
K
I
-
A
-
R
G
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
A
S
T
T
T
P
S
G
-
E
A
L
A
L
Q
-
V
T
H
Q
N
D
K
P
F
R
P
V
N
K
E
Q
T
-
Q
A
A
V
S
L
L
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
A
---------
G
Y
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
F
G
K
K
Y
L-
P
E
S
P
N
-
Q
Y
A
-------
A
H
E
A
I
R
P
S
D
---------
V
-------
N
V
M
A
E
S
L
-
K
D
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
--
F
R
L
K
A
R
G
R
I
L
--
R
--
F
D
G
W
TKV
M
P
A
L
R
--------
I
L
P
A
V
N
----
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
T
I
Q
D
R
G
Y
V
-
R
V
-
E
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
N
F
R
E
L
M
N
Y
D
F
T
A
Q
M
E
N
S
L
D
Q
V
A
N
H
E
A
E
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
L
D
K
A
E
K
D
P
E
E
G
G
M
R
P
N
Q
M
V
L
----------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
89.59
43%
-57
- C2 -
2GAJ
-
TOP1_THEMA
A:
[7-594]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
G
-------------------
N
E
Y
E
V
------------
F
A
S
M
------------
G
H
I
I
D
L
----
P
K
S
K
---------
F
G
-----
V
D
-
L
E
K
-
D
-
F
E
P
---
E
F
-------------------------
A
-------------------------
V
I
K
G
-
K
E
K
V
V
E
K
L
K
D
L
A
K
K
G
E
-
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
L
G
R
-
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
-
K
-
S
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
-------
T
V
-
N
F
D
G
-
L
-
T
A
E
I
D
V
K
E
K
K
F
F
D
A
E
T
L
-
K
E
I
Q
---
S
I
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
-
K
D
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
G
E
E
Y
VG----------------
A
H
E
A
I
R
P
T
N
---------
V
-------
F
M
T
P
E
E
A
G
K
Y
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
--
G
K
Y
R
F
K
G
T
V
L
--
K
K
I
F
D
G
Y
---
E
K
V
W
K
-
T
E
R
N
-
T
-
G
E
F
P
F
E
----
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
-
K
K
-
I
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
-----
I
V
V
D
F
P
T
N
Q
K
C
S
-
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
----
E
C
G
K
T
R
S
V
K
N
D
E
I
A
V
I
D
D
G
K
I
F
L
---------------------------------------------------------------------
12
PsiBlast_PDB
89.48
43%
-57
- C2 -
2GAI
-
TOP1_THEMA
A:
[7-594]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
G
-------------------
N
E
Y
E
V
------------
F
A
S
M
------------
G
H
I
I
D
L
----
P
K
S
K
---------
F
G
-----
V
D
-
L
E
K
-
D
-
F
E
P
---
E
F
-------------------------
A
-------------------------
V
I
K
G
-
K
E
K
V
V
E
K
L
K
D
L
A
K
K
G
E
-
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
L
G
R
-
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
-
K
-
S
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
-------
T
V
-
N
F
D
G
-
L
-
T
A
E
I
D
V
K
E
K
K
F
F
D
A
E
T
L
-
K
E
I
Q
---
S
I
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
-
K
D
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
G
E
E
Y
VG----------------
A
H
E
A
I
R
P
T
N
---------
V
-------
F
M
T
P
E
E
A
G
K
Y
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
--
G
K
Y
R
F
K
G
T
V
L
--
K
K
I
F
D
G
Y
---
E
K
V
W
K
-
T
E
R
N
-
T
-
G
E
F
P
F
E
----
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
-
K
K
-
I
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
-----
I
V
V
D
F
P
T
N
Q
K
C
S
-
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
----
E
C
G
K
T
R
S
V
K
N
D
E
I
A
V
I
D
D
G
K
I
F
L
---------------------------------------------------------------------
47
Fugue
89.01
43%
-53
- C2 -
2GAI
-
TOP1_THEMA
A:
[7-601]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
G
-------------------
N
E
Y
E
V
------------
F
A
S
M
------------
G
H
I
I
D
L
----
P
K
S
K
---------
F
G
-----
V
D
-
L
E
K
-
D
-
F
E
P
---
E
F
-------------------------
A
-------------------------
V
I
K
G
-
K
E
K
V
V
E
K
L
K
D
L
A
K
K
G
E
-
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
-
T
L
G
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
-
K
-
S
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
T
V
N
F
--------
D
G
-
L
-
T
A
E
I
D
V
K
E
K
K
F
F
D
A
E
T
L
-
K
E
I
Q
S
---
I
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
K
D
-
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
G
E
E
Y
----------------
V
G
A
H
E
A
I
R
P
T
N
---------
V
-------
F
M
T
P
E
E
A
G
K
Y
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
GK
Y
R
F
K
G
T
V
L
K
K
--
I
--
F
D
G
Y
---
E
K
V
W
K
T
E
R
N
T
-
G
--
E
F
P
F
E
----
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
-
K
K
-
I
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
I
V
V
D
F
P
T
N
Q
K
C
S
------
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
----
E
C
G
K
T
R
S
V
-
K
N
D
E
I
---
A
V
I
D
D
G
K
I
F
L
-----------------------------------------------------------------
22
HHSearch
88.51
43%
-50
* C2 *
2GAI
-
TOP1_THEMA
A:
[7-601]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
G
-------------------
N
E
Y
E
V
------------
F
A
S
M
------------
G
H
I
I
D
L
----
P
K
S
K
---------
F
G
-----
V
D
-
L
E
K
-
D
-
F
E
P
---
E
F
-------------------------
A
-------------------------
V
I
K
G
-
K
E
K
V
V
E
K
L
K
D
L
A
K
K
-
G
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
L
-
G
R
K
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
R
N
F
-
K
-
S
N
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
T
V
N
F
D
G
L
T
A
-
E
I
D
----
V
K
E
K
-----
K
F
F
-
D
A
E
T
L
K
E
I
Q
S
---
I
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
K
-
D
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
G
E
E
Y
--
V
G
--------------
A
H
E
A
I
R
P
T
N
---------
V
-------
F
M
T
P
E
E
A
G
K
Y
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
--
G
K
Y
R
F
K
G
T
V
L
K
K
I
--
F
D
G
Y
---
E
K
V
W
K
T
E
R
N
--
T
-
G
E
F
P
F
E
----
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
R
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
L
L
L
N
R
G
Y
I
-
K
K
-
I
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
Y
S
D
V
V
S
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
F
D
R
N
D
R
I
V
-----
V
D
F
P
T
N
Q
K
C
S
-
C
G
K
E
M
R
L
S
F
G
K
Y
G
F
Y
L
K
C
E
----
C
G
K
T
R
S
V
-
K
N
---------
D
E
I
A
V
----
I
D
D
G
K
I
F
L
-------------------------------------------------------
54
Fugue
82.37
33%
-34
- C2 -
4DDU
3
RGYR_THEMA
A:
[2-1103]
AVN
S
K
Y
H
HSCINCGGLNT
D
E
R
N
E
R
GLPCEVCLPEDSPSD
I
Y
R
A
L
L
E
R
KTLKE
Y
R
F
Y
H
E
F
W
N
E
Y
E
D
F
R
S
F
F
K
K
K
F
G
K
D
L
T
G
Y
Q
R
L
W
A
K
R
I
V
Q
G
K
S
F
T
MVAPTGVG
K
T
T
F
G
M
M
T
A
L
W
L
A
R
K
G
K
K
S
A
L
V
F
PT
V
T
L
V
K
Q
T
L
E
R
L
Q
K
L
ADEK
V
K
I
F
G
F
Y
SSMK
K
E
E
K
E
K
F
E
K
S
F
E
EDDYH
I
L
V
F
S
T
Q
F
V
S
K
N
R
E
K
L
S
Q
KRFD
F
V
F
V
DD
V
D
A
V
L
KA
S
R
N
I
D
T
L
L
M
M
VGIP
E
E
I
I
R
K
A
F
S
T
I
K
Q
G
K
I
Y
E
R
PKN
L
K
P
G
I
L
V
V
S
S
ATAKPRGIRP
L
L
F
R
D
L
LNFTVGRLVSVARN
I
T
H
V
R
I
SSRS
K
E
K
L
V
E
L
L
E
I
F
RDG
I
L
I
F
A
QT
E
E
E
G
K
E
L
Y
E
Y
L
K
R
F
KFNVGETWSEF
E
K
N
F
E
D
F
K
V
GKIN
I
L
I
G
V
Q
A
Y
Y
G
K
L
TRGVDLPERIK
Y
V
I
F
WG
T
P
S
M
R
F
S
LELDKAP
R
F
V
L
A
R
V
L
K
E
M
GLIK
A
Q
E
N
P
D
V
E
E
L
R
K
I
A
KEHLT
Q
K
E
F
V
E
K
V
K
E
M
FRGVVVKDEDL
E
L
I
I
P
D
V
Y
T
Y
I
Q
A
S
G
RSSRILNGVL
V
K
G
V
S
V
I
F
E
ED
E
E
I
F
E
S
L
K
T
R
L
L
L
IAE
E
E
I
I
E
EAEAN
W
K
E
L
V
H
E
V
E
E
S
R
R
R
S
E
R
E
L
T
D
T
S
R
S
L
L
I
I
V
E
S
P
T
K
A
E
T
L
S
R
F
L
G
RA
S
S
R
K
E
------------
R
N
I
I
V
------------
H
E
A
V
T
GE
G
V
I
L
F
T
A
TR
G
H
V
Y
D
L
VT--
K
G
G
I
---------
H
G
-----
V
E
-
E
E
N
G
K
-
F
V
P
---
V
Y
-------------------------
N
S
L
K
R
C
RDCGYQFTEDRDECPVCSSK
N
I
D
D
-
K
T
E
T
L
R
A
L
R
E
I
S
L
E
A
D
E
I
L
V
A
T
D
P
D
V
E
G
E
K
I
S
W
D
V
T
Q
Y
L
L
P
S
T
R
S
L
R
R
I
E
M
H
E
I
T
R
Y
G
F
K
K
A
R
E
S
V
R
F
V
D
F
N
L
V
K
A
Q
I
V
R
R
V
Q
D
R
W
I
G
F
E
L
S
G
K
L
Q
K
R
F
G
R
-
S
N
L
S
A
G
R
V
Q
S
T
V
L
G
W
I
V
E
R
E
E
E
Y
K
K
S
E
K
D
------------------
F
-
T
-
L
L
V
L
E
--------
N
G
V
N
-
L
E
V
E
G
K
I
A
D
D
V
V
T
V
V
E
L
Q
E
A
E
E
E
K
N
P
L
P
P
Y
T
T
S
S
A
L
S
E
I
S
Q
K
L
R
L
G
V
Q
E
V
M
D
I
L
Q
D
L
F
E
---------
K
G
F
I
T
Y
H
R
T
D
S
T
R
I
S
L
E
G
Q
N
V
A
R
T
Y
L
R
K
I
-
G
K
E
D
--
I
F
M
G
R
-
S
W
S
T
----
E
G
A
H
E
A
I
R
P
V
K
PID
A
R
E
L
--
E
-------
E
M
I
E
E
G
L
I
A
D
L
T
K
K
H
L
R
V
Y
E
L
I
F
N
R
F
L
A
S
Q
S
A
A
V
K
V
K
K
Q
I
V
T
V
D
V
D
G
K
-
R
M
G
I
E
Q
I
V
E
I
--
L
--
R
D
G
W
---
N
L
F
V
P
L
T
V
S
P
-
R
-
F
---------
E
H
R
T
Y
K
I
K
E
K
K
F
Y
K
K
H
T
V
P
L
--
F
T
Q
A
S
I
V
E
E
M
K
K
R
G
I
G
R
P
S
T
Y
A
K
I
V
E
V
L
F
R
R
G
Y
V
-
Y
E
D
K
Y
K
R
V
R
P
T
R
F
G
V
M
V
Y
S
Y
L
K
E
R
Y
E
K
Y
V
T
E
E
T
T
R
R
L
E
E
I
M
D
K
V
E
R
G
E
E
D
Y
Q
A
T
L
R
L
L
Y
E
E
I
K
S
L
M
E
E
---------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
77.96
30%
-37
- C2 -
1GKU
-
RGYR_ARCFU
B:
[1-1054]
------------------------------------------------------AAAAAAAAAAAAAAAAAAASLCLFPEDFLLKEFVEFFRKCVGEPRAIQKMWAKRILRKESFAATAPTGVGKTSFGLAMSLFLALKGKRCYVIFPTSLLVIQAAETIRKYAEKAGVGTENLIGYYHGRIPKREKENFMQNLRNFKIVITTTQFLSKHYRELGHFDFIFVDDVDAILKASKNVDKLLHLLGFHYDLKTKSWVGEARGCLMVSTATAKKGKKAELFRQLLNFDIGSSRITVRNVEDVAVNDESISTLSSILEKLGTGGIIYARTGEEAEEIYESLKNKFRIGIVTATKKGDYEKFVEGEIDHLIGTAHRGLDLPERIRFAVFVGCPSFRVTIEDIDSLSPQMVKLLAYLYRNVDEIERLLPAVERHIDEVREILKKVMGKERPQAKDVVVREGEVIFPDLRTYIQGSGRTSRLFAGGLTKGASFLLEDDSELLSAFIERAKLYDIEFKSIDEVDFEKL
S
R
E
L
D
E
S
R
D
R
Y
R
R
R
Q
E
F
D
L
I
K
P
A
L
F
I
V
E
S
P
T
K
A
R
Q
I
S
R
F
F
G
KPSVKVLDGAVVYEIPMQK
Y
V
L
M
V
------------
T
A
S
I
------------
G
H
V
V
D
L
IT--
N
R
G
F
---------
H
G
-----
V
L
-
V
N
G
-
R
-
F
V
P
---
V
Y
-------------------------
A
-------------------------
S
I
K
D
N
S
R
S
R
I
E
A
L
R
K
L
A
H
D
A
E
F
V
I
V
G
T
D
P
D
T
E
G
E
K
I
A
W
D
L
K
N
L
L
S
-
G
C
G
A
V
K
R
A
E
F
H
E
V
T
R
R
A
I
L
E
A
L
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S
L
R
D
V
D
E
N
L
V
K
A
Q
V
V
R
R
I
E
D
R
W
I
G
F
V
L
S
Q
K
L
W
E
R
F
-
N
N
R
N
L
S
A
G
R
A
Q
T
L
V
L
G
W
I
I
D
R
F
Q
E
S
R
E
R
R
K
I
A
I
V
--------------------------------
R
D
F
D
-
L
V
L
E
H
D
E
E
E
F
D
L
T
I
K
L
V
E
E
R
E
E
L
R
T
P
L
P
P
Y
T
T
E
T
M
L
S
D
A
N
R
I
L
K
F
S
V
K
Q
T
M
Q
I
A
Q
E
L
F
E
N
---------
G
L
I
T
Y
H
R
T
D
S
T
R
V
S
D
V
G
Q
R
I
A
K
E
Y
L
G
D
D
F
V
-------------
G
R
E
W
G
E
S
G
A
H
E
C
I
R
P
T
R
PLTRDDVQR
L
-------
I
Q
E
G
V
L
V
V
E
G
L
R
W
E
H
F
A
L
Y
D
L
I
F
R
R
F
M
A
S
Q
C
R
P
F
K
V
V
V
K
K
Y
S
I
E
F
D
G
--
K
T
A
E
E
E
R
I
V
R
--
A
--
E
G
R
A
---
Y
E
L
Y
R
A
V
W
V
K
-
N
-
E
L
P
T
-----------
G
T
F
R
V
K
A
E
V
K
S
V
P
K
V
L
P
F
T
Q
S
E
I
I
Q
M
M
K
E
R
G
I
G
R
P
S
T
Y
A
T
I
V
D
R
L
F
M
R
N
Y
V
-
V
E
-
K
Y
G
R
M
I
P
T
K
L
G
I
D
V
F
R
F
L
V
R
R
Y
A
K
F
V
S
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D
R
T
R
D
L
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S
R
M
D
A
I
E
R
G
E
L
D
Y
L
K
A
L
E
D
M
Y
A
E
I
K
S
-----------------------------------------------------------------------------------------------------------------------------------------
I
D
14
PsiBlast_PDB
75.40
29%
-34
- C2 -
4DDT
1
RGYR_THEMA
A:
[539-1095]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
R
S
L
L
I
I
V
E
S
P
T
K
A
E
T
L
S
R
F
L
G
RA
S
S
R
KE------------
R
N
I
I
V
H
E
A
V
T
GE
G
V
I
L
F
T
A
T
R
------------
G
H
V
Y
D
L
VT--
K
G
G
I
---------
H
G
-----
V
E
-
E
E
N
-
G
K
F
V
P
---
V
Y
N
S
L
K
R
C
RDCG
Y
Q
F
T
E
DRDECPVCSS
K
-------------------------
N
I
D
D
-
K
T
E
T
L
R
A
L
R
E
I
S
L
E
A
D
E
I
L
V
A
T
D
P
D
V
E
G
E
K
I
S
W
D
V
T
Q
Y
L
L
P
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T
R
S
L
R
R
I
E
M
H
E
I
T
R
Y
G
F
K
K
A
R
E
S
V
R
F
V
D
F
N
L
V
K
A
Q
I
V
R
R
V
Q
D
R
W
I
G
F
E
L
S
G
K
L
Q
K
R
F
G
R
-
S
N
L
S
A
G
R
V
Q
S
T
V
L
G
W
I
V
E
R
E
E
E
---------------
Y
K
K
S
E
K
-
D
F
T
L
-----------
L
V
L
E
N
G
V
N
L
-
E
-
V
E
G
K
I
A
D
D
V
V
T
V
V
E
L
Q
E
A
E
E
E
K
N
P
L
P
P
Y
T
T
S
S
A
L
S
E
I
S
Q
K
L
R
L
G
V
Q
E
V
M
D
I
L
Q
D
L
F
E
---------
K
G
F
I
T
Y
H
R
T
D
S
T
R
I
S
L
E
G
Q
N
V
A
R
T
Y
L
-----
R
K
I
--
G
K
E
D
I
-
F
M
G
R
S
W
S
T
E
G
A
H
E
A
I
R
P
V
K
---------
P
ID
A
R
E
L
E
E
M
I
E
E
G
L
I
A
D
L
T
K
K
H
L
R
V
Y
E
L
I
F
N
R
F
L
A
S
Q
S
A
A
-------
V
K
V
K
K
Q
I
--
V
T
V
D
V
D
G
K
R
M
--
G
--
I
E
Q
I
---
V
E
I
L
R
D
-
G
W
N
-
L
-
F
V
P
L
T
V
S
P
RF
E
H
R
T
Y
K
I
K
E
K
K
F
Y
K
K
H
T
V
P
L
--
F
T
Q
A
S
I
V
E
E
M
K
K
R
G
I
G
R
P
S
T
Y
A
K
I
V
E
V
L
F
R
R
G
Y
V
Y
E
D
-
K
Y
K
R
V
R
P
T
R
F
G
V
M
V
Y
S
Y
L
K
E
R
Y
E
K
Y
V
T
E
E
T
T
R
R
L
E
E
I
M
D
K
V
E
R
G
E
E
D
Y
Q
A
T
L
R
L
L
Y
E
E
I
K
S
L
M
E
E
---------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
74.99
29%
-34
- C2 -
4DDW
1
RGYR_THEMA
A:
[539-1095]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
R
S
L
L
I
I
V
E
S
P
T
K
A
E
T
L
S
R
F
L
G
RA
S
S
R
K
E
------------
R
N
I
I
V
H
E
A
V
T
GE
G
V
I
L
F
T
A
T
R
------------
G
H
V
Y
D
L
V
T--
K
G
G
I
---------
H
G
-----
V
E
-
E
E
N
-
G
K
F
V
P
---
V
Y
N
S
L
K
R
C
RDCGYQFTEDRDECPVCSS
K
-------------------------
N
I
D
D
-
K
T
E
T
L
R
A
L
R
E
I
S
L
E
A
D
E
I
L
V
A
T
D
P
D
V
E
G
E
K
I
S
W
D
V
T
Q
Y
L
L
P
S
T
R
S
L
R
R
I
E
M
H
E
I
T
R
Y
G
F
K
K
A
R
E
S
V
R
F
V
D
F
N
L
V
K
A
Q
I
V
R
R
V
Q
D
R
W
I
G
F
E
L
S
G
K
L
Q
K
R
F
G
R
-
S
N
L
S
A
G
R
V
Q
S
T
V
L
G
W
I
V
E
R
E
E
E
---------------
Y
K
K
S
E
K
-
D
F
T
L
-----------
L
V
L
E
N
G
V
N
L
-
E
-
V
E
G
K
I
A
D
D
V
V
T
V
V
E
L
Q
E
A
E
E
E
K
N
P
L
P
P
Y
T
T
S
S
A
L
S
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I
S
Q
K
L
R
L
G
V
Q
E
V
M
D
I
L
Q
D
L
F
E
---------
K
G
F
I
T
Y
H
R
T
D
S
T
R
I
S
L
E
G
Q
N
V
A
R
T
Y
L
-----
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K
I
--
G
K
E
D
I
-
F
M
G
R
S
W
S
T
E
G
A
H
E
A
I
R
P
V
K
---------
P
ID
A
R
E
L
E
E
M
I
E
E
G
L
I
A
D
L
T
K
K
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L
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F
L
A
S
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A
A
-------
V
K
V
K
K
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--
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V
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--
G
--
I
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Q
I
---
V
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L
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D
-
G
W
N
-
L
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F
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L
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K
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K
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K
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--
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A
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M
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K
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I
G
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Y
A
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-
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R
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D
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E
E
D
Y
Q
A
T
L
R
L
L
Y
E
E
I
K
S
L
M
E
E
---------------------------------------------------------------------------------------------------------------------------------------