@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1084: (2015-12-05 )
MSILEVKNLSHGFGDRAIFENVSFRLLKGEHIGLIGANGEGKSTFMSIVTGHLQPDEGKIEWSKYVTAGYLDQHTVLEKGQTVRDVLRTAFDELFKTEARINDIYISMADDGADVDSLMEEVGELQDRLESRDFYTLDAKIDEVARALGVMDFGMDSDVTELSGGQRTKVLLAKLLLEKPDILLLDEPTNYLDAEHIDWLKRYLQNYENAFVLISHDIPFLNDVINIVYHVENQDLVRYSGDYTNFESVYAMKKAQLEAAYERQQKEIADLQDFVNRNKARVATRNMAMSRQKKLDKMDIIELQAEKPKPSFEFKESRTPGRFIFQAKDLQIGYDRALTKPLNLTFERNQKIAIVGANGIGKTTLLKSLLGIIPPISGNVERGDFIDLGYFEQEVPGGNRQTPLEAVWDAFPALNQAEVRAALARCGLTSKHIESQIQVLSGGEQSKVRFCLLMNRENNVLVLDEPTNHLDVDAKDELKRALKAYKGSILMVCHEPDFYEGWMDDVWDFNQLS
Atome Classification :
(20 SA)
------------------------------------------------------------------.........10....-------.-...20-......-..------.30........40........50.....--.--..60---....--------------.----------.--..---.70....-.-...--80...--..----...90........100...-.....110.......120-........130.......140.......150..-----.....160.......170.......180.........190..-.---.---...200.....----..---210..-....---.---220.......230-----........240.......250.......260.......270.......280.......290.......300........310....-...320.......330..--.---....340---........350.......360.......370...---------------------...-.380...---------.-----------...390.-..----.-------------------------------------------------------------------------.--.----.400...-....410---------------------------------------------------------------------------------------------------------..-.------.----.....420.......430----.-.......440.......450......---.460.......470...----....480...----...----.490.......500.......510.---------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------M
S
I
L
E
VKNLSHGFG
D
-------
R
-
A
I
F
E--NV
S
F
R
L
-LK------G
E
H
I
G
L
I
GANGEG
K
S
T
F
M
S
I
V
T
GHLQPD--E--G
K
I
----
E
W
S
K
--------------
Y
----------
V
--TA---GYL
D
Q
H
T
-
V
-LEK--
G
Q
T
V
R
--
D
V
----
L
R
T
A
F
D
E
L
F
K
TEAR
I
-
N
D
I
-
Y
I
S
MADDGA
D
V
D
S
L
M
E
E
--
V
G
E
L
Q
D
R
L
ESRD
F
Y
T
LD
A
K
I
D
E
V
A
R
A
L
G
V
M
DFG-----MDSD
V
T
ELSGG
Q
R
T
K
V
L
L
A
K
L
L
LEKP--
D
I
L
L
LDEPTNYL
D
A
-
E
---
H
---
I
D
W
L
K
R
Y
L
Q
NY----E
N
---
A
F
V
L
I
-SHDI---
P
---
F
L
N
D
V
I
N
I
V
YHV------ENQ
D
L
V
R
YSGDYT
N
F
E
S
V
Y
A
M
K
K
A
Q
L
E
A
A
Y
E
R
Q
Q
K
E
I
A
D
L
Q
D
F
V
N
R
N
K
A
R
V
A
T
R
N
M
A
M
S
R
Q
KKLDKM
D
I
-
I
E
L
QAEKPKPSFEFKE-SRTP
G
R
F
I
F
Q
AKD
L
Q
IGY--D---RALTKP----
L
N
L
T
F
ERN
Q
K
I
A
I
V
GANGI
G
K
T
T
L
L
K
S
L
L
G
IIPP---------------------ISG-NVERG
D
F
---------
I
-----------DL
G
Y
F
E
Q-EV----P-------------------------------------------------------------------------G--G----NRQ
T
P
L
E
-
A
V
W
D
A-----------------------------------------------------------------------------------------------------------FP-A------L----
N
Q
A
E
V
R
A
A
L
A
RCGL
T
S
K
-----
H
-
I
E
S
Q
I
Q
VLSGGEQ
S
K
V
R
F
C
L
L
MNREN---
N
V
L
V
LDEPTNHLDVD
A
K
----
D
E
L
K
R
A
L
K
AY----KG
S
----
I
L
M
V
CHEP
D
F
Y
E
G
W
M
D
D
VWDFNQLS---------------------------------------------------------------
1
PsiBlast_PDB
89.31
29%
-69
- C1 -
3J5S
-
ETTA_ECOLI
D:
[25-520]
----------------------------------------------------------------------------------------
R
-
H
I
L
K
--
N
I
S
L
S
F
-
F
P
------
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
--
E
--
G
E
A
----
R
P
Q
P
--------------
D
----------
I
--
K
I
---
G
Y
L
P
Q
E
P
-
Q
-
L
N
P
--
E
H
T
V
R
--
E
S
----
I
E
E
A
V
S
E
V
V
N
A
L
K
R
L
-
D
E
V
-
Y
A
L
Y
A
D
P
D
A
D
F
D
K
L
A
A
E
--
Q
G
R
L
E
E
I
I
Q
A
H
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
D
W
-------
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
--
D
M
L
L
L
D
E
P
T
N
H
L
D
A
-
E
---
S
---
V
A
W
L
E
R
F
L
H
D
F
----
E
G
---
T
V
V
A
I
-
T
H
D
R
---
Y
---
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
G
R
Q
S
K
G
K
A
--
R
L
A
R
F
E
E
L
N
S
-
T
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
-
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G-
D
---
R
L
L
I
D
D
----
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
---------------------
D
S
G
-
T
I
T
L
G
E
T
---------
V
-----------
K
L
A
S
V
D
Q
F
R
D
----
S
-------------------------------------------------------------------------
M
--
D
----
N
S
K
T
V
W
E
-
E
V
S
G
G
-----------------------------------------------------------------------------------------------------------
L
D
-
I
------
M
KIGN
T
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
-----
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
----
R
A
L
E
N
A
L
L
E
F
----
P
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
E
G
---------------------------------------------------------------
2
PsiBlast_PDB
89.30
29%
-83
- C1 -
4FIN
13
ETTA_ECOLI
A:
[19-514]
----------------------------------------------------------------------------------------
R
-
H
I
L
K
--
N
I
S
L
S
F
-
F
P
------
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
--
E
--
G
E
A
----
R
P
Q
P
--------------
D
----------
I
--
K
I
---
G
Y
L
P
Q
E
P
-
Q
-
L
N
P
--
E
H
T
V
R
--
E
S
----
I
E
E
A
V
S
E
V
V
N
A
L
K
R
L
-
D
E
V
-
Y
A
L
Y
A
D
P
D
A
D
F
D
K
L
A
A
E
--
Q
G
R
L
E
E
I
I
Q
------
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
D
W
-------
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
--
D
M
L
L
L
D
E
P
T
N
H
L
D
A
-
E
---
S
---
V
A
W
L
E
R
F
L
H
D
F
----
E
G
---
T
V
V
A
I
-
T
H
D
R
---
Y
---
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
----
K
G
K
A
--
R
L
A
R
F
E
E
L
N
S
-
T
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
-
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G-
D
---
R
L
L
I
D
D
----
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
---------------------
D
S
G
-
T
I
T
L
G
E
T
---------
V
-----------
K
L
A
S
V
D
Q
F
R
D
----
S
-------------------------------------------------------------------------
M
--
D
----
N
S
K
T
V
W
E
-
E
V
S
G
G
-----------------------------------------------------------------------------------------------------------
L
D
-
I
------
M
KIGN
T
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
-----
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
----
R
A
L
E
N
A
L
L
E
F
----
P
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
E
G
---------------------------------------------------------------
21
HHSearch
87.51
28%
-84
- C1 -
2IW3
7
EF3A_YEAST
A:
[439-973]
------------------------------------------------------------------------
C
E
F
S
L
A
Y
G
A
-------
K
-
I
L
L
N
--
K
T
Q
L
R
L
-
K
R
------
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
----
D
--
G
F
P
----
T
Q
-
E
--------------
E
----------
C
--
R
T
---
V
Y
V
E
H
D
I
-
D
G
T
H
S
--
D
T
S
V
L
--
D
F
----
V
F
E
S
G
-----------------------------------------------
V
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
D
E
M
-----
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
-
V
---
N
---
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
-
S
H
D
S
---
V
---
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
-----
Y
E
E
-------
L
S
N
T
--------------------
D
L
E
----
F
K
F
----
P
E
P
G
Y
-
L
E
G
-
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
--
P
GTS
K
P
Q
I
T
D
----
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
-
E
V
Y
T
H
E
N
---------
C
-----------
R
I
A
Y
I
K
Q
-
H
A
----
F
-------------------------------------------------------------------------
A
--
H
IESH
L
D
K
T
P
S
E
-
Y
I
Q
W
R
F
Q
TGEDRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
NIGMKS
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQ
F
R
-
P
------
L
----
T
R
K
E
I
E
E
H
C
S
M
L
G
L
D
P
E
-----
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
---
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
----
G
A
L
S
K
A
L
K
E
F
----
E
G
G
----
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
D
G
R
---------------------------------------------------------------
7
PsiBlast_PDB
71.55
25%
-60
- C1 -
3OZX
5
?
A:
[28-459]
------------------------------------------------------------------------------------------------------------------
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
G
E
I
I
P
N
--
F
--
G
----------------------------------------------
D
P
N
S
-
K
-
V
G
K
--
D
E
V
L
K
--
R
F
RGKE
I
Y
N
Y
F
K
E
L
Y
S
N
E
L
K
I
V
H
K
I
Q
Y
V
E
Y
A
S
K
-----
F
L
K
G
T
--
V
N
E
I
L
T
K
I
D
E
R
------
G
K
K
D
E
V
K
E
L
L
N
M
T
N
L
------
W
N
K
D
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
--
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
R
E
---
R
---
M
N
M
A
K
A
I
R
E
L
L
----
K
N
---
K
Y
V
I
V
V
D
H
D
L
I
V
L
D
---
Y
L
T
D
L
I
H
I
I
Y
G
----------------------
E
S
----------
S
V
Y
G
R
V
S
K
S
Y
A
A
R
V
G
I
N
N
F
L
K
G
Y
L
P
A
E
N
M
K
I
----
R
P
D
E
I
K
F
-
M
L
K
----------
L
K
T
-
K
M
K
W
T
K
I
I
K
K
L
G
D
F
Q
L
V
V
--
D
---
N
G
E
A
K
-----------
E
G
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
I
L
V
G
E
I
T
A
---------------------
D
E
G
-
S
V
T
P
E
K
Q
---------
I
------------
L
S
Y
K
P
Q
-
R
I
F---
P
-------------------------------------------------------------------------
N
YD
G
----
T
V
Q
Q
Y
L
E
N
A
S
K
D
A
-----------------------------------------------------------------------------------------------------------
L
S
-
T
SS
W
F
--
F
----
E
E
V
T
K
R
L
N
L
H
R
L
------------
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
---
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
T
R
E
R
----
K
A
V
----
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
V
F
K
G
E
P
---------------------------------------------------------------
24
HHSearch
67.86
23%
-58
- C1 -
1YQT
4
?
A:
[25-477]
------------------------------------------------------------------------
E
D
C
V
H
R
Y
G
V
N------
A
-
F
V
L
Y
--
R
L
P
-
V
V
-
K
E
------
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
--
L
CG
D
N
D
----
S
W
D
G
--------------
V
----------
I
--
R
A
F
R-
G
N
E
L
Q
N
Y
F
E
-
K
L
K
--
N
G
E
I
R
--
P
V
----
V
K
P
Q
Y
V
D
L
I
-----------------
P
----
K
A
V
K
G
K
--
V
I
---
E
---
L
L
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
E
N
-
V
-----
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
--
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
-
R
---
Q
---
R
L
N
A
A
R
A
I
R
R
L
S
E
E
-
G
K
---
S
V
L
V
V
-
E
H
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L
---
A
---
V
L
D
Y
L
S
D
I
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
Q
P
K
G
T
R
N
---------------
G
I
N
E
F
L
R
G
Y
L
K
D
----
E
N
--
V
---
R
F
R
P
Y
E
--
I
K
F
T
K
--
T
G
E
R
------
V
E
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
--
G
---
S
F
R
L
E
V
----
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
-
K
I
E
W
D
L
----------------------
T
V
A
Y
K
P
Q
-
Y
I
----
K
-------------------------------------------------------------------------
A
--
D
----
Y
E
G
T
V
Y
E
-
L
L
S
K
I
-----------------------------------------------------------------------------------------------------------
D
A
-
S
K
L
----
N
----
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
------
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
----
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
G
E
P
---------------------------------------------------------------
25
HHSearch
66.45
19%
-72
- C1 -
3OZX
5
?
A:
[4-461]
-------------------------------------------------------------------------
E
V
I
H
R
Y
K
V
N------
G
-
F
K
L
F
--
G
L
P
T
-
P
-
K
N
------
N
T
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
G
E
I
I
P
N
--
F
--
G
D
P
----
N
S
K
V
--------------
G
K
D
E
V
L
K
R
F
RG
K
--
E
I
---
Y
N
Y
F
K
E
L
-
Y
--
S
N
--
E
L
K
I
V
--
H
K
----
I
Q
Y
V
E
Y
-
A
S
-----------------------
K
F
L
K
----
G
T
V
N
E
I
L
---
T
K
I
D
E
R
G
K
K
D
E
V
K
E
L
L
N
M
T
N
-
L
-----
W
N
K
D
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
--
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
-
R
---
E
---
R
M
N
M
A
K
A
I
R
E
L
L
K--
N
K
---
Y
V
I
V
V
-
D
H
D
L
---
I
---
V
L
D
Y
L
T
D
L
I
H
I
I
------
Y
-
G
E
S
S
V
Y
G
R
V
S
K
S
Y
A
A
R
V
G
I
N
------
N
F
---------
L
K
G
Y
L
P
A
------
E
--
N
--
M
K
I
R
P
D
E
I
K
F
M
-
L
K
-------------------
L
K
T
K
M
K
W
T
K
I
I
K
K
L
--
G
---
D
F
Q
L
V
V
----
D
N
G
E
A
K
E
G
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
I
L
V
G
E
I
T
A
---------------------
D
E
G
-
S
V
T
P
E
K
----------
Q
-----------
I
L
S
Y
K
P
Q
-
R
I
----
F
-------------------------------------------------------------------------
P
--
N
----
Y
D
G
T
V
Q
Q
-
Y
L
E
N
A
-----------------------------------------------------------------------------------------------------------
S
K
-
D
ALS---
T
----
S
S
W
F
F
E
E
V
T
K
R
L
N
L
H
R
------
L
-
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
---
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
----
Y
I
V
A
K
A
I
K
R
V
T
R
E
R
K
A
V
----
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
V
F
K
G
E
P
---------------------------------------------------------------
4
PsiBlast_PDB
63.20
24%
-93
- C1 -
2IX3
6
EF3A_YEAST
A:
[441-743]
--------------------------------------------------------------------------
F
S
L
A
Y
G
A
-------
K
-
I
L
L
N
--
K
T
Q
L
R
L
-
K
R
------
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
-------------------------
R
--------------
A
----------
I
--
A
N
---
G
Q
V
D
G
-------------------------------
F
P
T
Q
E
E
C
-
R
T
V
-
Y
V
E
H
D
I
D
G
T
H
S
D
T
--------
S
V
L
D
F
V
F
E
S
G
V
G
T
K
E
A
I
K
D
K
L
I
E
-
F
G
F
T
D
E
M
-----
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
-
V
---
N
---
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
-
S
H
D
S
---
V
---
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
-----
V
K
K
C
P
A
A
K
A
Y
E
----------------------------------
E
L
S
N
-
T
D
L
E
F
K
F
P
E
P
G
Y
-
L
E
G
-
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
--
P
----
G
T
S
K
P
QITD
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
-
E
V
Y
T
H
E
N
---------
C
-----------
R
I
A
Y
I
K
Q
-
H
A
----
F
-------------------------------------------------------------------------
A
--
H
----
I
E
S
H
L
D
K
-
T
P
S
E
Y
-----------------------------------------------------------------------------------------------------------
I
Q
-
W
------
R
----
F
Q
T
G
E
D
R
E
T
M
D
R
A
N
R
Q
I
-----
N
-
E
N
D
A
E
A
M
N
K
I
F
K
I
E
G
T
P
R
R
I
A
G
I
H
S
R
---
R
K
F
K
N
T
Y
E
Y
E
C
S
F
L
L
G
E
----
N
I
G
M
K
S
E
R
W
V
----
P
M
M
----
S
V
D
N
A
W
I
P
R
G
E
L
V
E
S
H
S
K
M
V
A
E
V
D
M
---------------------------------------------------------------
46
Fugue
62.64
18%
-52
- C1 -
3J16
4
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
EILCIGCG
I
C
V
K
K
CP
F
D
A
I
Q
I
I
N
L
P
T
N
L
E
A
-------
H
-
V
T
H
R
YS
A
N
S
F
K
L
-
H
R
L
P
T
P
R
P
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V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
--
L
--
G
R
-------------------------------------
F
D
---
D
P
P
E
W
Q
E
-
I
-
I
K
Y
--
F
R
--
G
--
S
E
----
L
Q
N
Y
F
T
K
M
L
E
------
D
D
I
-
K
A
I
I
K
P
Q
Y
V
D
N
I
P
R
A
I
K
GP
V
Q
K
V
G
E
L
L
K
L
R
M
-
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
V
------
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
--
D
V
Y
M
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S
Y
L
D
V
-
K
---
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---
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L
N
A
A
Q
I
I
R
S
L
----
L
A
P
T
K
Y
V
I
C
V
-
E
H
D
L
---
S
---
V
L
D
Y
L
S
D
F
V
C
I
I
------
Y
G
V
P
---------
S
V
Y
G
V
V
T
L
P
A
S
V
R
E
G
I
N
I
F
L
D
-------
G
H
I
P
A
E
N
L
R
F
R
T
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A
L
Q
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A
D
A
T
E
D
L
Q
N
-
D
S
A
S
R
A
F
S
Y
P
S
L
K
K
T
-----
Q
G
D
F
V
L
N
V
E
E
G
E
-----------------------
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
---------------------
D
E
G
-
Q
D
I
P
K
-----------
L
-----------
N
V
S
M
K
P
Q
-
K
I
----
A
-------------------------------------------------------------------------
P
--
K
----
F
P
G
T
V
R
Q
-
L
F
F
K
K
-----------------------------------------------------------------------------------------------------------
I
R
G
Q
------
F
----
L
N
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
-----
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
----
I
I
C
S
K
V
I
R
R
F
----
I
L
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
I
P
S
K
N
A
H
A
R
A
P
ES
L
L
T
G
C
N
R
F
L
K
N
L
NVTFRRDPNSF
R
P
R
I
N
K
L
DS
Q
M
D
K
E
Q
K
S
S
GNYFFLDNTGI
3
PsiBlast_PDB
62.37
24%
-92
- C1 -
2IWH
8
EF3A_YEAST
A:
[441-743]
--------------------------------------------------------------------------
F
S
L
A
Y
G
A
-------
K
-
I
L
L
N
--
K
T
Q
L
R
L
-
K
R
------
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
-------------------------
R
--------------
A
----------
I
--
A
N
---
G
Q
V
D
G
-------------------------------
F
P
T
Q
E
E
C
-
R
T
V
-
Y
V
E
H
D
I
D
G
T
H
S
D
T
--------
S
V
L
D
F
V
F
E
S
G
V
G
T
K
E
A
I
K
D
K
L
I
E
-
F
G
F
T
D
E
M
-----
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
-
V
---
N
---
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
-
S
H
D
S
---
V
---
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
-----
V
K
K
C
P
A
A
K
A
Y
E
----------------------------------
E
L
S
N
-
T
D
L
E
F
K
F
P
E
P
G
Y
-
L
E
G
-
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
--
P
----
G
T
S
K
P
QITD
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
-
E
V
Y
T
H
E
N
---------
C
-----------
R
I
A
Y
I
K
Q
-
H
A
----
F
-------------------------------------------------------------------------
A
--
H
----
I
E
S
H
L
D
K
-
T
P
S
E
Y
-----------------------------------------------------------------------------------------------------------
I
Q
-
W
------
R
----
F
Q
T
G
E
D
R
E
T
M
D
R
A
N
R
Q
I
-----
N
-
E
N
D
A
E
A
M
N
K
I
F
K
I
E
G
T
P
R
R
I
A
G
I
H
S
R
---
R
K
F
K
N
T
Y
E
Y
E
C
S
F
L
L
G
E
----
N
I
G
M
K
S
E
R
W
V
----
P
M
M
----
S
V
D
N
A
W
I
P
R
G
E
L
V
E
S
H
S
K
M
V
A
E
V
D
M
---------------------------------------------------------------
22
HHSearch
62.21
22%
-52
- C1 -
3BK7
4
?
A:
[83-547]
--------------------------------------------------------------------
A
I
S
I
V
N
L
P
E
Q
L
D
E
D
CVHRYG
V
-
N
A
F
V
--
L
Y
R
L
P
I
V
K
D
------
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
--
L
--
C
E
D
----
N
D
S
W
--------------
D
----------
N
---
V
---
I
R
A
F
R
G
N
-
E
-
L
Q
N
--
Y
F
E
R
L
K
N
G
E
----
I
R
P
V
V
K
P
Q
Y
V
--
D
L
------
L
-----
P
----
K
A
V
K
G
K
--
V
R
E
---
L
L
---
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
-
V
-----
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
--
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
-
R
---
Q
---
R
L
K
V
A
R
V
I
R
R
L
A
N
E
-
G
K
---
A
V
L
V
V
-
E
H
D
L
---
A
---
V
L
D
Y
L
S
D
V
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
--
N
E
---------
F
L
Q
G
Y
L
K
D
E
N
V
----------
R
F
R
P
-
Y
E
I
R
--
F
T
K
----
L
S
E
-----
R
-
V
D
V
E
R
E
T
L
V
E
Y
P
R
L
V
K
D
Y
--
G
---
S
F
K
L
E
V
----
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
-
K
V
E
W
D
L
----------------------
T
V
A
Y
K
P
Q
-
Y
I
----
K
-------------------------------------------------------------------------
A
--
E
----
Y
E
G
T
V
Y
E
-
L
L
S
K
I
-----------------------------------------------------------------------------------------------------------
D
S
-
S
K
L
----
N
----
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
------
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
----
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
G
E
P
---------------------------------------------------------------
5
PsiBlast_PDB
61.74
24%
-92
- C1 -
2IW3
6
EF3A_YEAST
A:
[441-743]
--------------------------------------------------------------------------
F
S
L
A
Y
G
A
-------
K
-
I
L
L
N
--
K
T
Q
L
R
L
-
K
R
------
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
-------------------------
R
--------------
A
----------
I
--
A
N
---
G
Q
V
D
G
-------------------------------
F
P
T
Q
E
E
C
-
R
T
V
-
Y
V
E
H
D
I
D
G
T
H
S
D
T
--------
S
V
L
D
F
V
F
E
S
G
V
G
T
K
E
A
I
K
D
K
L
I
E
-
F
G
F
T
D
E
M
-----
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
-
V
---
N
---
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
-
S
H
D
S
---
V
---
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
-----
V
K
K
C
P
A
A
K
A
Y
E
----------------------------------
E
L
S
N
-
T
D
L
E
F
K
F
P
E
P
G
Y
-
L
E
G
-
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
--
P
----
G
T
S
K
P
QITD
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
-
E
V
Y
T
H
E
N
---------
C
-----------
R
I
A
Y
I
K
Q
-
H
A
----
F
-------------------------------------------------------------------------
A
--
H
----
I
E
S
H
L
D
K
-
T
P
S
E
Y
-----------------------------------------------------------------------------------------------------------
I
Q
-
W
------
R
----
F
Q
T
G
E
D
R
E
T
M
D
R
A
N
R
Q
I
-----
N
-
E
N
D
A
E
A
M
N
K
I
F
K
I
E
G
T
P
R
R
I
A
G
I
H
S
R
---
R
K
F
K
N
T
Y
E
Y
E
C
S
F
L
L
G
E
----
N
I
G
M
K
S
E
R
W
V
----
P
M
M
----
S
V
D
N
A
W
I
P
R
G
E
L
V
E
S
H
S
K
M
V
A
E
V
D
M
---------------------------------------------------------------
23
HHSearch
61.07
19%
-62
- C1 -
3J16
2
RLI1_YEAST
B:
[81-543]
------------------------------------------------------------------------
A
H
V
T
H
R
Y
S
A
-------
N
S
F
K
L
H
--
R
L
P
-
T
P
-
R
P
------
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
--
L
--
G
R
F
----
D
D
P
P
--------------
E
----------
W
Q
E
I
I
---
K
Y
F
R
-
G
S
-
E
-
L
Q
N
Y
F
T
K
M
L
E
--
D
D
----
I
K
A
I
I
K
P
Q
Y
V
--
D
N
----
I
-
P
R
A
I
-------
K
G
P
V
Q
K
--
V
G
E
----
L
L
K
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
-
V
-----
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
--
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
-
K
---
Q
---
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
-
T
K
---
Y
V
I
C
V
-
E
H
D
L
---
S
---
V
L
D
Y
L
S
D
F
V
C
I
I
------
Y
G
V
P
S
V
-
Y
-
G
---
V
V
T
L
P
A
S
V
R
E
G
--
I
N
I
F
---------
L
D
G
H
I
P
A
E
--------
N
L
R
F
R
---
T
E
A
L
Q
--
F
R
I
A
D
--
A
T
E
D
----
L
-
Q
N
D
S
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
--
G
---
D
F
V
L
N
V
----
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
---------------------
D
E
G
-
Q
D
I
P
--
K
---------
L
-----------
N
V
S
M
K
P
Q
-
K
I
----
A
-------------------------------------------------------------------------
P
--
K
----
F
P
G
T
V
R
Q
-
L
F
F
K
K
-----------------------------------------------------------------------------------------------------------
I
R
-
G
QF----
L
----
N
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
-
D
-----
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
----
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
T
----
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
I
P
---------------------------------------------------------------
12
PsiBlast_PDB
59.25
21%
-60
- C1 -
4CRM
3
RLI1_YEAST
P:
[103-513]
---------------------------------------------------------------------------------------------------------------
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
--
L
--
G
R
F
DDPP
E
W
Q
E
--------------
I
----------
I
--
K
-----
Y
F
---------
R
--
G
S
E
L
Q
--
N
Y
----
F
T
K
M
L
E
D
D
I
K
--
A
I
I
-
K
P
Q
-
Y
V
D
N
I
P
R
A
--
I
K
G
P
V
Q
K
--
V
G
E
L
---
L
K
L
R
----
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
NV---
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
--
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
-
K
QRL
N
---
A
A
Q
I
I
R
S
L
L
A
P
----
T
K
---
Y
V
I
C
V
-
E
H
D
L
---
S
VLD
Y
L
S
D
F
V
C
I
I
Y
G
V
---------------------
P
S
V
Y
G
V
--
V
T
L
P
A
S
V
-
R
E
G
I
N
I
F
-
L
D
G
H
I
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
A
T
E
------
D
L
Q
N
D
S
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
G
D
F
V
L
N
V
E
E
G
E
-----------------------
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
---------------------
D
E
G
Q
D
I
P
K
------------
L
-----------
N
V
S
M
K
P
Q
-
K
I
APKF
P
-------------------------------------------------------------------------
G
--
T
----
V
R
Q
L
F
F
K
-
K
I
R
G
Q
-----------------------------------------------------------------------------------------------------------
F
---------
L
----
N
-
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
-----
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
----
I
I
C
S
K
V
I
R
R
F
----
I
L
H
----
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
---------------------------------------------------------------
11
PsiBlast_PDB
59.11
21%
-63
- C1 -
3J16
2
RLI1_YEAST
B:
[103-513]
---------------------------------------------------------------------------------------------------------------
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
--
L
--
G
R
F
DDPP
E
W
Q
E
--------------
I
----------
I
--
K
-----
Y
F
---------
R
--
G
S
E
L
Q
--
N
Y
----
F
T
K
M
L
E
D
D
I
K
--
A
I
I
-
K
P
Q
-
Y
V
D
N
I
P
R
A
--
I
K
G
P
V
Q
K
--
V
G
E
L
---
L
K
L
R
----
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
NV---
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
--
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
-
K
Q
R
L
N
---
A
A
Q
I
I
R
S
L
L
A
P
----
T
K
---
Y
V
I
C
V
-
E
H
D
L
---
S
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
V
---------------------
P
S
V
Y
G
V
--
V
T
L
P
A
S
V
-
R
E
G
I
N
I
F
-
L
D
G
H
I
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
A
T
E
------
D
L
Q
N
D
S
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
G
D
F
V
L
N
V
E
E
G
E
-----------------------
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
---------------------
D
E
G
Q
D
I
P
K
------------
L
-----------
N
V
S
M
K
P
Q
-
K
I
A
P
KF
P
-------------------------------------------------------------------------
G
--
T
----
V
R
Q
L
F
F
K
-
K
I
R
G
Q
-----------------------------------------------------------------------------------------------------------
F
---------
L
----
N
-
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
-----
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
----
I
I
C
S
K
V
I
R
R
F
----
I
L
H
----
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
---------------------------------------------------------------
8
PsiBlast_PDB
58.39
23%
-49
- C1 -
3BK7
2
?
A:
[117-515]
---------------------------------------------------------------------------------------------------------------
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
LC
E
--
D
N
D
----
S
W
D
N
--------------
V
----------
I
--
R
A
F
RG
N
E
L
Q
N
Y
F
-
E
-
R
L
K
--
N
G
E
I
R
--
P
V
----
V
K
P
Q
Y
V
D
L
L
P
K
A
V
K
--------------------------
G
K
V
R
E
L
L
K
---------
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
ELENV
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
--
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
-
R
---
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
----
G
K
---
A
V
L
V
V
-
E
H
D
L
---
A
V
L
D
Y
L
S
D
V
I
H
V
V
Y
G
--------------
E
P
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
-----------
L
Q
G
Y
L
K
D
E
N
V
R
F
--
R
P
Y
E
I
R
F
T
K
L
S
E
R
V
D
V
E
R
E
T
L
V
E
Y
P
R
L
V
K
D
Y
-------
G
S
F
K
L
E
V
E
P
G
E
I
-----------------------
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
-
K
V
E
W
D
-----------
L
-----------
T
V
A
Y
K
P
Q
-
Y
I
----
K
-------------------------------------------------------------------------
A
--
E
----
Y
E
G
T
-----
V
Y
E
L
-----------------------------------------------------------------------------------------------------------
L
S
-
K
------
I
----
D
S
S
K
L
N
S
N
F
Y
K
T
E
L
L
K
P
LGIID
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
----
L
A
V
S
R
A
I
R
H
L
----
M
E
K
----
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
---------------------------------------------------------------
40
HHSearch
56.99
22%
-82
- C1 -
1Z47
1
?
A:
[11-221]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
PG
G
---
A
R
S
V
R
G
----
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
---------------------
T
K
G
-
D
V
W
I
G
G
K
RVTDLPPQK
R
-----------
N
V
G
L
V
F
Q
-
N
Y
----
A
-------------------------------------------------------------------------
L
--
F
----
Q
H
M
T
V
Y
D
-
N
V
S
F
G
-----------------------------------------------------------------------------------------------------------
L
R
-
E
K
RVP
K
D
E
----
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
------
Y
-
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
---
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
----
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
----
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
---------------------------------------------------------------
39
HHSearch
56.77
25%
-107
- C1 -
3D31
-
?
A:
[1-210]
--------------------------------------------------------------------
M
I
E
I
E
S
L
S
R
K
W
K
N
---------
F
S
L
D
--
N
L
S
L
K
V
-
E
S
------
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
--
S
--
G
R
I
----
L
L
D
G
KDVTDLSPE-----
K
----------
H
--
D
I
---
A
F
V
Y
Q
N
Y
-
S
-
L
F
P
--
H
M
N
V
K
--
K
N
----
L
E
F
G
M
R
M
K
-
K
------------------------------------------
I
K
D
P
K
R
V
L
D
T
A
R
D
L
K
I
E
H
-
L
-----
L
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
--
K
I
L
L
L
D
E
P
L
S
A
L
D
P
-
R
---
T
---
Q
E
N
A
R
E
M
L
S
V
L
H
K
KN
K
L
---
T
V
L
H
I
-
T
H
D
Q
---
T
---
E
A
R
I
M
A
D
R
I
A
V
V
------
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
P
V
E
G
R
V
A
S
F
V
G
F
E
N
V
L
K
G
R
V
I
S
A
E
Q
G
L
L
R
I
R
V
G
E
V
V
I
D
A
A
G
D
M
E
V
G
D
Q
V
Y
A
F
-
L
R
P
E
N
I
A
L
S
K
S
S
T
Q
S
S
-
I
R
N
S
L
Q
G
R
V
T
E
A
W
V
L
G
A
L
--
V
---
R
V
K
V
D
C
----
G
V
P
L
N
V
L
I
T
R
R
S
A
E
E
M
E
L
S
P
G
V
Q
I
Y
A
R
F
K
A
S
S
V
H
---------------------
V
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
56.54
22%
-101
- C1 -
1V43
-
?
A:
[10-227]
------------------------------------------------------------------
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
-------
F
-
T
A
V
N
--
K
L
N
L
T
I
-
K
D
------
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
--
E
--
G
R
I
----
Y
F
G
D
RDVTYLPPK-----
D
----------
R
--
N
I
---
S
M
V
F
Q
----------
H
M
T
V
Y
--
E
N
----
I
A
F
P
L
--
K
K
F
----------------------------------------
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
-
L
-----
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
--
D
V
L
L
M
D
E
P
L
S
N
L
D
A
-
K
---
L
---
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
---
T
T
I
Y
V
-
T
H
D
Q
---
V
---
E
A
M
T
M
G
D
R
I
A
V
M
------
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
G
D
G
Y
L
E
G
R
G
F
R
I
E
L
P
Q
M
D
L
L
K
D
Y
V
G
K
T
V
L
F
-
G
I
R
P
E
H
M
T
V
E
G
V
H
M
K
R
-
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
--
I
---
L
H
V
K
F
G
----
D
E
L
V
K
V
K
L
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
---------------------
D
T
E
-
K
A
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
55.66
25%
-98
- C1 -
3TUI
1
METN_ECOLI
C:
[23-250]
-------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
GTRT---
I
-
Q
A
L
N
--
N
V
S
L
H
V
-
P
A
------
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
--
E
--
G
S
V
----
L
V
D
G
QELTTLSESELTKA
R
----------
R
--
Q
I
---
G
M
I
F
Q
H
F
-
N
-
L
L
S
--
S
R
T
V
F
--
G
N
----
V
A
L
P
L
E
L
D
N
T
----------------------------------------
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
-----
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
--
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
-
A
---
T
---
T
R
S
I
L
E
L
L
K
D
I
NRRL
G
L
---
T
I
L
L
I
-
T
H
E
M
---
D
---
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
-
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
-
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
-
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
--
H
---
G
T
Q
Q
D
T
----
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
G
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
54.54
20%
-50
- C1 -
2R6F
3
?
A:
[487-921]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
Q
N
V
G
L
D
Y
L
T
-----
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
TG
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
-
R
---
D
---
N
D
R
L
I
A
T
L
K
S
M
R
D
L-
G
N
---
T
L
I
V
V
-
E
H
D
E
---
D
---
T
M
L
A
-
A
D
Y
L
I
D
I
G
PGAGI
H
G
G
E
V
V
A
A
-
G
T
P
E
E
V
M
N
D
P
N
S
L
----
T
G
-------------
Q
Y
--------------------
L
S
G
K
K
--
F
-
I
----
P
I
P
A
----
E
-
R
R
R
P
D
G
R
W
L
E
V
V
G
A
R
---------
E
H
N
L
K
N
----
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
LHRAK
A
K
P
G
EHRDIRGLEH
L
D
K
-
V
I
D
I
D
Q
S
---------
P
IGRTPRSN
P
A
T
Y
T
G
V
F
D
D
-
I
R
----
D
V
F
A
S
T
N
E
A
K
V
R
GYKKGRFSFNVKGGRCEACHGDG
I
I
K
I
E
M
H
FL
P
D
V
Y
V
P
CEVCHGKRYNRETLEVTYKGKN
I
A
E
--
V
----
L
D
M
T
V
E
D
-
A
L
D
F
F
-----------------------------------------------------------------------------------------------------------
A
S
-
I
------
P
----
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
-----
K
-
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
NGR
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
----
A
R
L
L
D
V
L
H
R
L
V
D
N
-
G
D
T
----
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
---------------------------------------------------------------