@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1109: (2015-12-05 )
MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSREEANTRETVTAYREYKQVIQNISDAEEMIKDASGDAELEEMAKEELKESKAAKEEYEERLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAETQGWRFEVMESSVNGVGGIKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYEIDQKDLRVDIYHASGAGGQNVNKVATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTILSGKMDEVIDALVMYDQTQKLEALNK
Atome Classification :
(20 SA)
-------------------.........10........20....-------....30........40....--....50.........60.......------.70........80...-.....90........100--......---.110.......120.....---------------..130-.........140.------......150.-......160.......170.......180.......190.......200.......210-.-.-.---.-...220.....-----..230.......240.....--------------------.---------------------.------250---.-----------------.---.-......260...--------------....270.......280.......290.--......300.......310.......320....-----------------...330....-----...340--.......350..--.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------M
N
I
Y
D
Q
L
Q
A
V
E
D
R
Y
E
E
L
G
E
L
LSDPD-------
V
V
S
D
T
K
R
F
M
E
L
S
R
EEAN
T
R
E
--
T
V
T
A
Y
-
R
E
Y
K
Q
V
I
Q
N
IS
D
A
E
E
M
I
K
------DASG
D
A
E
L
E
E
M
A
K
E
E
L
-
K
E
S
K
A
A
K
E
E
Y
E
E
R
L
K
I
L
L
--
L
PKDPN---DD
K
N
I
I
L
E
I
RGAAGGD
E
A
A
---------------
L
F
A
---
G
D
L
L
T
M
Y
Q
K
Y
A
ET------QG
W
R
F
E
V
M
E
S-SVNGV
G
G
I
K
E
V
V
A
M
VS
G
Q
S
V
Y
S
K
LKYESGA
H
R
V
Q
RVPVTESQ
G
R
V
HT
S
T
A
T
V
L
VMP
E
V
E
-
E
-
V
-
E
---Y-EIDQKD
L
R
V
D
I
-----
Y
HASGAGGQ
N
V
N
K
V
A
T
A
V
R
M
--------------------
V
---------------------H------I-----P-----------------T---G-
I
K
V
E
M
Q
E
E
R
T
Q
Q--------------K
N
R
D
K
A
M
K
I
I
R
A
R
V
A
D
H
F
A
Q
I
A
Q
D
E
Q
D
A
--
E
R
KSTVGTGD
R
S
E
R
I
R
TYNFPQNRVTDHRI
G
L
T
-----------------
L
Q
K
L
D
T
I
LSG-----
K
M
D
E
V
I
--
D
A
L
V
MYD
Q
T
Q
K
L
--
E
ALNK
1
PsiBlast_PDB
79.43
48%
-61
- C5 -
2B3T
-
RF1_ECOLI
B:
[7-354]
-----------------------
A
K
L
E
A
L
H
E
R
H
E
E
V
Q
A
L
L
G
D
A
Q
-------
T
I
A
D
Q
E
R
F
R
A
L
S
R
E
Y
A
Q
L
S
D
--
V
S
R
C
F
-
T
D
W
Q
Q
V
----------------------------------------------
Q
Q
L
Q
V
L
L
--
L
P
K
D
P
D
---
D
E
R
N
A
F
L
E
V
R
A
G
T
G
G
D
E
A
A
---------------
L
F
A
---
G
D
L
F
R
M
Y
S
R
Y
A
E
A
------
R
R
W
R
V
E
I
M
S
A
-
S
E
G
E
H
G
G
Y
K
E
I
I
A
K
I
S
G
D
G
V
Y
G
R
L
K
F
E
S
G
G
H
R
V
Q
R
V
P
A
T
E
S
Q
G
R
I
H
T
S
A
C
T
V
A
V
M
P
E
L
P
-
D
-
A
-
E
---
L
P
D
V
N
P
A
D
L
R
I
D
T
-----
F
R
S
S
G
A
G
G
Q
H
V
N
T
T
D
S
A
I
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-
I
V
V
E
C
Q
D
E
R
S
Q
H
--------------
K
N
K
A
K
A
L
S
V
L
G
A
R
I
--
H
A
A
E
M
A
K
R
Q
------
R
R
N
-------
S
D
R
N
R
T
Y
N
F
P
Q
G
R
V
T
D
H
R
I
N
L
T
-----------------
L
Y
R
L
D
E
V
M
E
G
-----
K
L
D
M
L
I
--
E
P
I
I
Q
E
H
Q
A
D
Q
L
--
A
----
19
HHSearch
77.35
48%
-53
- C5 -
2B3T
-
RF1_ECOLI
B:
[7-354]
-----------------------
A
K
L
E
A
L
H
E
R
H
E
E
V
Q
A
L
L
G
D
A
Q
-------
T
I
A
D
Q
E
R
F
R
A
L
S
R
E
Y
A
Q
L
S
D
--
V
S
R
C
F
-
T
D
W
Q
Q
V
----------------------------------------------
Q
Q
L
Q
V
L
L
--
L
P
K
D
P
D
---
D
E
R
N
A
F
L
E
V
R
A
G
T
G
G
D
E
A
A
---------------
L
F
A
---
G
D
L
F
R
M
Y
S
R
Y
A
E
A
------
R
R
W
R
V
E
I
M
S
A
-
S
E
G
E
H
G
G
Y
K
E
I
I
A
K
I
S
G
D
G
V
Y
G
R
L
K
F
E
S
G
G
H
R
V
Q
R
V
P
A
T
E
S
Q
G
R
I
H
T
S
A
C
T
V
A
V
M
P
E
L
P
-
D
-
A
E
L
---
P
-
D
V
N
P
A
D
L
R
I
D
T
-----
F
R
S
S
G
A
G
G
Q
H
V
N
T
T
D
S
A
I
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-
I
V
V
E
C
Q
D
E
R
S
Q
H
--------------
K
N
K
A
K
A
L
S
V
L
G
A
R
I
H
A
A
E
M
A
K
R
Q
--------
R
R
N
-------
S
D
R
N
R
T
Y
N
F
P
Q
G
R
V
T
D
H
R
I
N
L
T
-----------------
L
Y
R
L
D
E
V
M
E
G
-----
K
L
D
M
L
I
--
E
P
I
I
Q
E
H
Q
A
D
Q
L
--
A
----
22
HHSearch
71.17
45%
-42
- C5 -
1RQ0
-
RF1_THEMA
A:
[1-333]
----------------------------
M
K
E
K
K
K
E
I
E
K
L
L
A
R
P
D
-------
L
T
P
E
--
Q
M
K
N
Y
G
M
E
Y
A
K
I
E
E
--
I
E
N
I
T
-
N
R
I
K
E
T
Q
E
----
F
I
E
L
L
R
------
E
----
E
---
G
E
N
E
L
E
I
-
E
K
Y
E
K
E
L
D
Q
L
Y
Q
E
L
L
F
L
L
--
S
---
P
E
---
A
S
D
K
A
I
V
E
I
R
P
G
T
G
G
E
E
A
A
---------------
L
F
A
---
R
D
L
F
R
M
Y
T
R
Y
A
E
R
------
K
G
W
N
L
E
V
A
E
I
-
H
E
T
D
L
G
G
I
R
E
V
V
F
F
V
K
G
K
N
A
Y
G
I
L
K
Y
E
S
G
V
H
R
V
Q
R
V
P
V
T
E
S
G
G
R
I
H
T
S
T
A
T
V
A
V
L
P
E
I
E
-
E
-
K
-
D
---
I
-
E
I
R
P
E
D
L
K
I
E
T
-----
F
R
A
S
G
----
Y
V
N
K
T
E
S
A
V
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-
I
V
V
S
C
Q
N
E
R
S
Q
Y
--------------
Q
N
K
Q
T
A
L
R
I
L
R
A
R
L
Y
Q
L
Q
K
E
Q
K
E
R
E
I
S
Q
------------
R
S
E
K
I
R
T
Y
N
F
P
Q
N
R
V
T
D
H
R
I
N
Y
T
-----------------
S
Y
R
L
Q
E
I
L
D
G
-----
D
L
D
E
I
I
--
S
K
L
I
E
H
D
I
E
N
N
L
--
E
E
V
L
-
2
PsiBlast_PDB
69.69
53%
-57
- C5 -
1RQ0
-
RF1_THEMA
A:
[76-330]
----------------------------------------------------------------------------------------------------------------------------------------
L
L
--
F
L
L
S
P
E
---
A
S
D
K
A
I
V
E
I
R
P
G
T
G
G
E
E
A
A
---------------
L
F
A
---
R
D
L
F
R
M
Y
T
R
Y
A
E
R
------
K
G
W
N
L
E
V
A
E
I
-
H
E
T
D
L
G
G
I
R
E
V
V
F
F
V
K
G
K
N
A
Y
G
I
L
K
Y
E
S
G
V
H
R
V
Q
R
V
P
V
T
E
S
G
G
R
I
H
T
S
T
A
T
V
A
V
L
P
E
I
E
-
E
-
K
-
D
---
I
-
E
I
R
P
E
D
L
K
I
E
T
-----
F
R
A
S
G
----
Y
V
N
K
T
E
S
A
V
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-
I
V
V
S
C
Q
N
E
R
S
Q
Y
--------------
Q
N
K
Q
T
A
L
R
I
L
R
A
R
L
Y
Q
L
Q
K
E
Q
K
E
R
E
I
S
Q
------------
R
S
E
K
I
R
T
Y
N
F
P
Q
N
R
V
T
D
H
R
I
N
Y
T
-----------------
S
Y
R
L
Q
E
I
L
D
G
-----
D
L
D
E
I
I
--
S
K
L
I
E
H
D
I
E
N
N
L
--
E
E
V
L
-
18
HHSearch
68.05
92%
29
- C5 -
1ZBT
-
RF1_STRMU
A:
[3-358]
---------------------
I
Y
D
Q
L
Q
A
V
E
D
R
Y
E
E
L
---------------------------
R
E
E
A
N
S
R
E
--
T
V
A
V
Y
-
R
E
Y
K
Q
V
V
Q
N
I
A
D
A
Q
E
M
-------------
P
E
L
E
E
M
A
K
E
E
L
-
K
N
S
K
V
A
K
E
E
Y
E
E
K
L
R
F
L
L
--
L
P
K
D
P
N
---
D
D
K
N
I
I
L
E
I
R
G
A
A
G
G
D
E
A
A
---------------
L
F
A
---
G
D
L
L
N
M
Y
Q
K
Y
A
E
N
------
Q
G
W
K
F
E
V
M
E
A
-
S
A
N
G
V
G
G
L
K
E
V
V
A
M
V
S
G
Q
S
V
Y
S
K
L
K
Y
E
S
G
A
H
R
V
Q
R
V
P
V
T
E
S
Q
G
R
V
H
T
S
T
A
T
V
L
V
M
P
E
V
E
-
E
-
V
-
E
---
Y
-
E
I
D
P
K
D
L
R
V
D
I
-----
Y
H
A
---------
K
V
A
T
A
V
R
I
--------------------
I
---------------------
H
------
L
-----
P
-----------------
T
---
N
-
I
K
V
E
M
Q
E
E
R
T
Q
Q
--------------
K
N
R
D
K
A
M
K
I
I
R
A
R
V
A
D
H
F
A
Q
I
A
Q
D
E
Q
D
A
------
T
V
G
T
G
D
R
S
E
R
I
R
T
Y
N
F
P
Q
N
R
V
T
D
H
R
I
G
L
T
-----------------
L
Q
K
L
D
S
I
L
S
G
-----
K
L
D
E
V
I
--
D
A
L
I
L
Y
D
Q
T
Q
K
L
--
E
E
L
N
-
6
PsiBlast_PDB
52.92
34%
28
- C5 -
1GQE
-
RF2_ECOLI
A:
[24-359]
----------------------
Y
L
D
Y
D
A
K
K
E
R
L
E
E
V
N
A
E
L
E
Q
P
D
-------
V
W
N
E
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
E
A
--
V
V
D
T
L
-
D
Q
M
K
Q
G
L
E
D
V
S
G
L
L
E
L
A
V
------
E
A
D
D
E
--------
E
T
F
-
N
E
A
V
A
E
L
D
A
L
E
E
K
L
A
Q
L
E
--
F
R
R
M
F
S
GEY
D
S
A
D
C
Y
L
D
I
Q
A
G
S
G
G
T
E
A
Q
---------------
D
W
A
---
S
M
L
E
R
M
Y
L
R
W
A
E
S
------
R
G
F
K
T
E
I
I
E
E
-
S
E
G
E
V
A
G
I
K
S
V
T
I
K
I
S
G
D
Y
A
Y
G
W
L
R
T
E
T
G
V
H
R
L
V
R
K
S
P
F
D
S
G
G
R
R
H
T
S
F
S
S
A
F
V
Y
P
E
V
D
-
D
D
I
-
D
---
I
-
E
I
N
P
A
D
L
R
I
D
V
-----
Y
R
A
S
G
A
G
G
Q
H
V
N
R
T
E
S
A
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-
I
V
T
Q
C
Q
N
D
R
S
Q
H
--------------
K
N
K
D
Q
A
M
K
Q
M
K
A
K
L
Y
E
V
E
M
Q
K
K
N
A
E
K
Q
A
ME
D
N
K
S
D
I
G
W
G
---
S
Q
I
R
S
Y
V
L
D
D
S
R
I
K
D
L
R
T
G
V
E
-----------------
T
R
N
T
Q
A
V
L
D
G
-----
S
L
D
Q
F
I
--
E
A
S
L
K
A
G
L
-----------
20
HHSearch
52.10
34%
34
- C5 -
1GQE
-
RF2_ECOLI
A:
[25-363]
-----------------------
L
D
Y
D
A
K
K
E
R
L
E
E
V
N
A
E
L
E
Q
P
D
-------
V
W
N
E
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
E
A
--
V
V
D
T
L
-
D
Q
M
K
Q
G
L
E
D
V
S
G
L
L
E
L
A
V
------
E
A
-
D
D
E
E
T
F
N
E
A
V
A
E
L
-
D
A
L
E
E
K
L
A
Q
L
E
F
R
----
R
--
M
F
S
G
E
Y
---
D
S
A
D
C
Y
L
D
I
Q
A
G
S
G
G
T
E
A
Q
---------------
D
W
A
---
S
M
L
E
R
M
Y
L
R
W
A
E
S
------
R
G
F
K
T
E
I
I
E
E
-
S
E
G
E
V
A
G
I
K
S
V
T
I
K
I
S
G
D
Y
A
Y
G
W
L
R
T
E
T
G
V
H
R
L
V
R
K
S
P
F
D
S
G
G
R
R
H
T
S
F
S
S
A
F
V
Y
P
E
V
D
D
D
-
I
-
D
---
I
-
E
I
N
P
A
D
L
R
I
D
V
-----
Y
R
A
S
G
A
G
G
Q
H
V
N
R
T
E
S
A
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-
I
V
T
Q
C
Q
N
D
R
S
Q
H
--------------
K
N
K
D
Q
A
M
K
Q
M
K
A
K
L
Y
E
V
E
M
Q
K
K
N
A
E
K
Q
A
--
M
E
D
-
N
K
S
D
I
G
W
G
S
Q
I
R
S
Y
V
L
D
D
S
R
I
K
D
L
R
T
G
V
E
-----------------
T
R
N
T
Q
A
V
L
D
G
-----
S
L
D
Q
F
I
--
E
A
S
L
K
A
G
L
-----------
3
PsiBlast_PDB
49.79
53%
111
- C- -
2FVO
-
RF1_THEMA
A:
[76-330]
----------------------------------------------------------------------------------------------------------------------------------------
L
L
--
F
L
L
S
P
E
---
A
S
D
K
A
I
V
E
I
R
P
G
T
G
G
E
E
A
A
---------------
L
F
A
---
R
D
L
F
R
M
Y
T
R
Y
A
E
R
------
K
G
W
N
L
E
V
A
E
I
-
H
E
T
D
L
G
G
I
R
E
V
V
F
F
V
K
G
K
N
A
Y
G
I
L
K
Y
E
S
G
V
H
R
V
Q
R
V
P
V
T
E
S
G
G
R
I
H
T
S
T
A
T
V
A
V
L
P
E
I
E
-
E
-
K
-
D
---
I
-
E
I
R
P
E
D
L
K
I
E
T
-----
F
R
A
S
G
---------
E
S
A
V
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-
I
V
V
S
C
Q
N
E
R
S
Q
Y
--------------
Q
N
K
Q
T
A
L
R
I
L
R
A
R
L
Y
Q
L
Q
K
E
Q
K
E
R
E
I
S
Q
------------
R
S
E
K
I
R
T
Y
N
F
P
Q
N
R
V
T
D
H
R
I
N
Y
T
-----------------
S
Y
R
L
Q
E
I
L
D
G
-----
D
L
D
E
I
I
--
S
K
L
I
E
H
D
I
E
N
N
L
--
E
E
V
L
-
5
PsiBlast_PDB
46.37
34%
164
- C- -
1ML5
1
RF2_ECOLI
Z:
[24-359]
----------------------
Y
L
D
Y
D
A
K
K
E
R
L
E
E
V
N
A
E
L
E
Q
P
D
-------
V
W
N
E
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
E
A
--
V
V
D
T
L
-
D
Q
M
K
Q
G
L
E
D
V
S
G
L
L
E
L
----------
A
V
E
A
D
D
E
E
T
F
N
E
A
V
-
A
E
L
D
A
L
E
E
K
L
A
Q
-
L
E
F
R
R
--
M
F
S
G
E
Y
---
D
S
A
D
C
Y
L
D
I
Q
A
G
S
G
G
T
E
A
Q
---------------
D
W
A
---
S
M
L
E
R
M
Y
L
R
W
A
E
S
------
R
G
F
K
T
E
I
I
E
E
-
S
E
G
E
V
A
G
I
K
S
V
T
I
K
I
S
G
D
Y
A
Y
G
W
L
R
T
E
T
G
V
H
R
L
V
R
K
S
P
F
D
S
G
G
R
R
H
T
S
F
S
S
A
F
V
Y
P
E
V
D
-
D
D
I
-
D
---
I
-
E
I
N
P
A
D
L
R
I
D
V
-----
Y
R
T
S
G
A
G
G
Q
H
V
N
R
T
E
S
A
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-
I
V
T
Q
C
Q
N
D
R
S
Q
H
--------------
K
N
K
D
Q
A
M
K
Q
M
K
A
K
L
Y
E
L
E
M
Q
K
K
N
A
E
K
Q
A
ME
D
N
K
S
D
I
G
W
G
---
S
Q
I
R
S
Y
V
L
D
D
S
R
I
K
D
L
R
T
G
V
E
-----------------
T
R
N
T
Q
A
V
L
D
G
-----
S
L
D
Q
F
I
--
E
A
S
L
K
A
G
L
-----------
4
PsiBlast_PDB
46.37
34%
164
- C- -
1MI6
-
RF2_ECOLI
A:
[24-359]
----------------------
Y
L
D
Y
D
A
K
K
E
R
L
E
E
V
N
A
E
L
E
Q
P
D
-------
V
W
N
E
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
E
A
--
V
V
D
T
L
-
D
Q
M
K
Q
G
L
E
D
V
S
G
L
L
E
L
----------
A
V
E
A
D
D
E
E
T
F
N
E
A
V
-
A
E
L
D
A
L
E
E
K
L
A
Q
-
L
E
F
R
R
--
M
F
S
G
E
Y
---
D
S
A
D
C
Y
L
D
I
Q
A
G
S
G
G
T
E
A
Q
---------------
D
W
A
---
S
M
L
E
R
M
Y
L
R
W
A
E
S
------
R
G
F
K
T
E
I
I
E
E
-
S
E
G
E
V
A
G
I
K
S
V
T
I
K
I
S
G
D
Y
A
Y
G
W
L
R
T
E
T
G
V
H
R
L
V
R
K
S
P
F
D
S
G
G
R
R
H
T
S
F
S
S
A
F
V
Y
P
E
V
D
-
D
D
I
-
D
---
I
-
E
I
N
P
A
D
L
R
I
D
V
-----
Y
R
A
S
G
A
G
G
Q
H
V
N
R
T
E
S
A
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-
I
V
T
Q
C
Q
N
D
R
S
Q
H
--------------
K
N
K
D
Q
A
M
K
Q
M
K
A
K
L
Y
E
V
E
M
Q
K
K
N
A
E
K
Q
A
M
E
D
N
K
S
D
I
G
W
G
---
S
Q
I
R
S
Y
V
L
D
D
S
R
I
K
D
L
R
T
G
V
E
-----------------
T
R
N
T
Q
A
V
L
D
G
-----
S
L
D
Q
F
I
--
E
A
S
L
K
A
G
L
-----------
23
HHSearch
42.10
24%
-32
- C5 -
2RSM
-
CL065_MOUSE
A:
[4-110]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
G
K
W
G
L
R
L
Q
E
K
P
A
L
L
F
P
G
-
M
A
A
S
T
V
Q
V
A
G
R
K
D
Y
P
---
A
-
L
---
L
-
P
L
N
E
S
E
L
E
E
Q
F
-----
V
K
G
H
G
P
G
G
Q
A
T
N
K
T
S
N
C
V
V
L
--------------------
K
---------------------
H
------
V
-----
P
-----------------
S
---
G
-
I
V
V
K
C
H
Q
T
R
S
V
D
--------------
Q
N
R
K
I
A
R
K
V
L
Q
E
K
V
D
V
F
Y
N
S
G
P
S
S
G
-------------------------------------------------------------------------------------------------
39
Fugue
40.93
20%
-26
- C3 -
4Q3K
3
?
A:
[20-260]
---------------------------------------------------------
Q
G
M
N
I
S
K
I
T
I
N
Q
H
V
G
V
T
L
T
C
Y
V
Q
D
V
S
Q
E
M
S
N
M
S
K
R
P
A
M
L
I
F
P
G
G
GY
Q
F
C
S
D
R
E
A
E
P
I
A
L
S
Y
L
-
A
K
G
----------
Y
N
A
F
V
--
L
R
Y
S
V
K
---
E
H
----------
A
V
F
P
R
P
L
---------------
I
D
A
---
E
D
A
L
S
Y
L
K
D
N
A
H
A
------
L
H
I
N
P
D
K
I
A
V
-
I
G
F
S
A
G
G
H
L
A
T
T
L
A
T
E
G
K
V
R
P
N
---------------------------
A
V
V
L
G
Y
P
A
L
I
-
R
-
H
-
E
---
K
-
Y
W
N
F
P
T
P
K
V
D
------------------
Q
Q
T
P
E
M
F
V
--------------------
F
---------------------
H
------
T
-----
F
-----------------
E
---
D
-
D
L
V
P
L
------------------------------------
S
H
P
L
Y
I
V
E
E
L
S
K
A
--------------------
N
I
P
V
E
F
H
L
F
K
S
G
V
H
G
-----------------
L
S
L
G
N
K
I
V
S
N
-----
G
L
D
K
M
I
ED
D
V
Q
V
W
F
D
L
S
C
R
W
L
D
K
V
L
D
L
27
HHSearch
40.67
32%
-13
- C5 -
2JY9
-
?
A:
[7-102]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
---
V
-
S
I
A
D
N
E
L
E
I
T
A
-----
I
R
A
Q
G
A
G
G
Q
H
V
N
K
T
S
S
A
I
H
L
--------------------
R
F
D
IRA
S
G
L
P
E
Y
Y
K
Q
R
L
L
T
ASH
H
------
L
-----
I
-----------------
S
DDG
V
-
I
I
I
K
A
Q
E
F
R
S
Q
E
--------------
L
N
R
E
A
A
I
A
R
L
V
A
V
I
K
E
L
T
A
E
Q
K
S
R
R
A
T
R
--
P
T
R
A
S
K
E
R
R
L
S
S
K
A
Q
K
S
S
V
K
A
L
R
G
K
V
R
R
P
L
D
L
E
-----------------
H
H
H
H
H
H
------------------------------------
7
PsiBlast_PDB
40.63
30%
-27
- C5 -
2RSM
-
CL065_MOUSE
A:
[43-104]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
E
S
E
L
E
E
Q
F
-----
V
K
G
H
G
P
G
G
Q
A
T
N
K
T
S
N
C
V
V
L
--------------------
K
---------------------
H
------
V
-----
P
-----------------
S
---
G
-
I
V
V
K
C
H
Q
T
R
S
V
D
--------------
Q
N
R
K
I
A
R
K
V
L
Q
E
K
V
D
V
F
Y
N
S
G
P
S
S
G
-------------------------------------------------------------------------------------------------
32
Fugue
40.08
18%
-7
- C5 -
1SET
-
SYS_THET2
A:
[1-110]
----------------------
M
V
D
L
K
R
L
R
Q
E
P
E
V
F
H
R
A
I
R
E
K
G
-------
V
A
L
D
L
E
A
L
L
A
L
D
R
E
V
Q
E
L
K
K
--
R
L
Q
E
V
-
Q
T
E
R
N
Q
V
A
K
R
V
P
K
A
P
P
E
E
------
K
E
A
L
I
A
R
G
K
A
L
-
G
E
E
A
-
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
---
P
G
A
P
V
G
G
E
E
A
N
R
E
I
K
R
V
G
G
---------------
P
P
E
---
F
S
F
P
P
L
D
H
V
A
L
M
E
------
K
N
G
W
W
E
P
R
I
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
-
Q
-
V
-
W
---
A
-
I
A
E
T
D
L
Y
L
T
G
T
-----
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
--------------------
L
---------------------
R
------
Y
-----
A
-----------------
G
---
Y
-
A
P
A
F
R
S
E
A
G
S
F
G
--------------
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
A
S
--
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
-----------------
P
G
K
W
R
Q
V
D
I
E
-----
V
Y
L
P
S
E
--
G
R
Y
R
E
T
H
S
C
S
A
L
--
L
D
W
Q
A
25
HHSearch
39.84
31%
-19
- C5 -
2JVA
-
?
A:
[7-101]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
---
V
-
H
L
P
D
A
E
I
E
L
T
A
-----
I
R
A
Q
G
A
G
G
Q
N
V
N
K
V
S
S
A
M
H
L
--------------------
R
---------------------
F
DINASS
L
-----
P
P
F
Y
K
E
R
L
L
A
LNDSRITS
D
---
G
V
I
V
L
K
A
Q
Q
Y
R
T
Q
E
--------------
Q
N
R
A
D
A
L
L
R
L
S
E
L
I
V
N
A
A
K
L
E
H
H
H
H
H
H
-----------------------------------------------------------------------------------------------
40
Fugue
34.57
15%
13
- C2 -
5A1F
14
KDM5B_HUMAN
A:
[1-458]
SM
F
L
P
P
P
E
C
P
V
F
E
P
S
WEEF
A
D
P
F
A
F
I
H
K
I
R
P
I
A
E
Q
T
G
I
C
K
V
R
P
P
PDWQP
P
F
A
C
D
V
D
K
L
H
F
T
P
R
I
Q
R
L
N
E
L
E
--
A
Q
T
R
V
-
R
D
Y
T
--
L
R
T
F
G
E
M
A
D
A
F
K
------
S
D
Y
F
N
M
P
V
H
M
V
P
T
E
L
V
E
K
E
F
W
R
L
V
S
T
I
E
E
D
V
T
V
E
Y
--
G
A
D
I
A
S
---
K
E
F
G
S
G
F
P
V
R
D
S
P
E
E
E
E
Y
L
D
SGWNLNNMPVMEQS
V
L
A
HIT
A
D
I
C
G
M
K
L
P
W
L
Y
V
G
M
CFSS
F
C
W
H
I
E
D
H
W
S
Y
S
I
N
Y
L
H
W
G
E
P
--
K
T
W
Y
G
V
P
G
Y
A
A
E
Q
L
E
N
V
M
K
K
L
A
P
E
L
F
V
S
Q
P
D
L
L
H
Q
L
V
-
T
I
M
N
P
N
T
L
M
-
T
-
H
-
E
V
P
V
Y
-
R
T
N
Q
C
A
G
E
F
V
I
T
F
P
R
A
Y
H
S
G
F
N
Q
G
F
N
F
A
E
A
V
N
F
C
T
V
--------------------
D
---------------------
W
------
L
-----
P
-----------------
L
---
G
-
R
Q
C
V
E
H
Y
R
L
L
H
R
YCVFS
H
D
E
M
I
C
K
M
A
S
K
A
D
V
L
D
V
V
V
A
S
T
V
Q
K
D
M
A
I
M
I
E
D
E
K
A
L
--
R
E
T
V
R
K
L
G
V
I
D
S
E
R
M
D
F
E
L
L
P
D
D
E
R
Q
C
V
K
C
K
T
T
CFM
S
A
I
S
C
SCKPG
L
L
V
C
L
H
H
V
K
E
L
C
S
C
PPYKY
K
L
R
Y
R
Y
--
T
L
D
D
L
Y
P
M
M
N
A
L
--
K
L
R
A
E
29
HHSearch
34.17
5%
102
- C5 -
2A26
-
CYBP_HUMAN
A:
[7-47]
----------------------------------------------------------------------------------
E
E
L
Q
K
D
L
E
E
V
K
V
L
L
E
------
K
A
-
T
R
K
R
V
R
D
A
L
T
A
E
K
-
S
K
I
E
T
E
I
K
N
K
M
Q
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
33.50
27%
9
- C5 -
1J26
-
ICT1_MOUSE
A:
[13-108]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
S
---
S
-
Y
I
P
L
D
R
L
S
I
S
Y
-----
C
R
S
S
G
P
G
G
Q
N
V
N
K
V
N
S
K
A
E
V
R
F
HLASADWIE
E
P
V
R
Q
K
I
A
L
T
---------------------
H
------
K
NKINK
A
-----------------
G
---
E
-
L
V
L
T
S
E
S
S
R
Y
Q
F
--------------
R
N
L
A
E
C
L
Q
K
I
R
D
M
I
A
E
A
S
G
P
S
S
G
---------------------------------------------------------------------------------------------------
30
HHSearch
33.22
5%
108
- C5 -
1YSM
-
CYBP_MOUSE
A:
[5-47]
---------------------------------------------------------------------------------
L
E
E
L
Q
K
D
L
E
E
V
K
V
L
L
E
------
K
S
-
T
R
K
R
L
R
D
T
L
T
S
E
K
-
S
K
I
E
T
E
L
K
N
K
M
Q
Q
K
S
Q
K
K
--
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------