@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1154: (2015-12-05 )
MFNDIPVFDYEDIQLIPNKCIISSRSQADTSVKLGNYTFKLPVIPANMQTIIDEEVAETLACEGYFYIMHRFNEEERKPFIKRMHDKGLIASISVGVKDYEYDFVTSLKEDAPEFITIDIAHGHSNSVIEMIQHIKQELPETFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCSKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSLFAGHLESPGKLVEVDGQQFKEYYGSASEYQKGEHKNVEGKKILLPVKGRLEDTLTEMQQDLQSSISYAGGKELDSLRHVDYVIVKNSIWNGDSI
Atome Classification :
(28 SA)
.........10........20........30....-.-...40-------.........50........60........70-..-...-------..-----------------------.80....-.--...90-------------------------------------------------------------------------------------------------..--------------.......100.......110-...--.....120.......130.......140.......150.......160.......170.......180.......190.......200--..---......210.......220.......230.......240.......250...--....260----...---.--..----..270.......280.......290.......300.......-310-.......320.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFNDIPVFDY
E
D
IQLI
P
N
K
CIISSRSQAD
T
S
V
K
LG-
N
-
Y
T
F
K
--------
L
PVIP
A
N
M
Q
T
I
I
D
E
E
V
A
E
T
L
ACE
G
Y
F
Y
I
M
H
R-F
N
-
E
E
E
-------
R
K
-----------------------
P
F
I
K
R
M
H-D--KG
L
I
--------------------------------------------------------------------------------------------------
A
S
--------------
I
SVGVKDY
E
Y
D
F
V
T
S
L
KED--AP
E
--
F
I
T
I
D
I
AHGHS
N
S
V
I
E
M
I
Q
H
I
K
Q
ELPE
T
F
V
I
AGNVG
T
P
E
A
V
R
E
L
E
NAGADATKVGIGPG
K
V
C
I
T
K
VKTGFGTGGW
Q
L
A
A
L
R
W
C
S
K
A
A---RK---
P
I
IADGGIR
T
H
G
D
I
A
K
S
I
RFG
A
S
M
V
M
I
G
S
L
F
A
G
HLESPG
K
L
V
EV
D
G
Q
Q
F
K
E
Y--YG
S
A
S
E-----YQK---G--EH----KNVEG
K
K
I
L
L
PVKG
R
L
E
D
T
L
T
E
M
Q
Q
D
L
Q
S
S
ISYAGGK
E
L
D
SL-RH
V
-
D
Y
V
I
V
KNSIWNGDSI
1
PsiBlast_PDB
97.36
75%
-100
- C2 -
2A1Y
1
GUAC_BACAN
A:
[13-330]
------
V
F
D
Y
E
D
I
Q
L
I
P
A
K
C
I
V
N
S
R
S
E
C
D
T
T
V
T
L
G
-
K
-
H
K
F
K
--------
L
P
V
V
P
A
N
M
Q
T
I
I
D
E
R
I
A
T
Y
L
A
E
N
N
Y
F
Y
I
M
H
R
-
F
Q
-
P
E
K
-------
R
I
-----------------------
S
F
I
R
D
M
Q
-
S
--
R
G
L
I
--------------------------------------------------------------------------------------------------
A
S
--------------
I
S
V
G
V
K
E
D
E
Y
E
F
V
Q
Q
L
A
A
E
HL
T
P
E
--
Y
I
T
I
D
I
A
H
G
H
S
N
A
V
I
N
M
I
Q
H
I
K
K
H
L
P
E
S
F
V
I
A
G
N
V
G
T
P
E
A
V
R
E
L
E
N
A
G
A
D
A
T
K
V
G
I
G
P
G
K
V
C
I
T
K
I
K
T
G
F
G
T
G
G
W
Q
L
A
A
L
R
W
C
A
K
A
A
---
S
K
---
P
I
I
A
D
G
G
I
R
T
N
G
D
V
A
K
S
I
R
F
G
A
T
M
V
M
I
G
S
L
F
A
G
H
E
E
S
P
G
E
T
I
E
K
---
L
Y
K
E
Y
--
F
G
S
-------------------------------
F
V
E
H
K
G
S
L
E
D
T
L
I
E
M
E
Q
D
L
Q
S
S
I
S
Y
A
G
G
T
K
L
D
S
I
-
R
T
V
-
D
Y
V
V
V
K
N
S
I
F
-----
49
PsiBlast_CBE
77.47
34%
-89
- C2 -
2A7R
2
GMPR2_HUMAN
D:
[24-357]
--
N
D
V
K
L
-
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
----
S
-
F
S
F
R
NSKQTYSG
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
HGL
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
-----------------------------
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
T
Q
Q
-------
8
PsiBlast_PDB
76.97
34%
-79
- C2 -
2A7R
3
GMPR2_HUMAN
A:
[24-356]
--
N
D
V
K
L
-
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
----
S
-
F
S
F
R
NSK
Q
T
Y
S
G
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
H
G
L
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
M
A
M
K
K
Y
A
G
---
G
VA
E
Y
----
R
A
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
T
Q
--------
56
PsiBlast_CBE
75.52
34%
-85
- C2 -
2C6Q
3
GMPR2_HUMAN
B:
[20-347]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
----
S
-
F
S
F
R
NSKQTYSG
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
HGL
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
MAMKK
Y
A
G
---
G
VA
E
Y
----
R
A
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
T
---------
62
PsiBlast_CBE
75.31
34%
-85
- C2 -
2BZN
1
GMPR2_HUMAN
C:
[20-346]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
---
E
V
D
L
T
R
----
S
-
F
S
F
R
NSK
Q
T
Y
S
G
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
H
G
L
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
M
A
M
K
K
Y
A
---------------
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
----------
59
PsiBlast_CBE
74.75
34%
-85
- C2 -
2BZN
1
GMPR2_HUMAN
F:
[20-347]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
----
S
-
F
S
F
R
NSKQTYSG
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
HGL
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
MAMKK
Y
A
---------------
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
T
---------
57
PsiBlast_CBE
74.68
34%
-87
- C2 -
2BZN
1
GMPR2_HUMAN
H:
[20-346]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
----
S
-
F
S
F
R
NSKQTYSG
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
HGL
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
MAMKK
Y
A
---------------
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
----------
50
PsiBlast_CBE
74.44
34%
-83
- C2 -
2C6Q
3
GMPR2_HUMAN
H:
[20-346]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
----
S
-
F
S
F
R
NSKQTYSG
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
HGL
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
MAMKK
Y
A
G
---
G
VA
E
Y
----
R
A
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
----------
58
PsiBlast_CBE
74.17
34%
-88
- C2 -
2BZN
1
GMPR2_HUMAN
G:
[20-347]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
----
E
V
D
L
T
R
----
S
-
F
S
F
R
NSKQTYSG
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
HGL
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
MAMKK
Y
A
---------------
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
T
---------
55
PsiBlast_CBE
73.95
34%
-84
- C2 -
2C6Q
3
GMPR2_HUMAN
C:
[20-346]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
----
S
-
F
S
F
R
NSKQTYSG
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
HGL
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
MAMKK
Y
A
G
---
G
VA
E
Y
----
R
A
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
----------
9
PsiBlast_PDB
73.64
34%
-85
- C2 -
2BZN
1
GMPR2_HUMAN
A:
[20-346]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
----
S
-
F
S
F
R
NSK
Q
T
Y
S
G
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
H
G
L
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
M
A
M
K
K
Y
A
---------------
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
----------
61
PsiBlast_CBE
73.54
34%
-87
- C2 -
2BZN
1
GMPR2_HUMAN
D:
[20-346]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
----
E
V
D
L
T
R
----
S
-
F
S
F
R
NSKQTYSG
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
HGL
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
MAMKK
Y
A
---------------
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
----------
51
PsiBlast_CBE
73.36
34%
-84
- C2 -
2C6Q
2
GMPR2_HUMAN
G:
[20-347]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
----
S
-
F
S
F
R
NSKQTYSG
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
HGL
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
MAMKK
Y
A
---------------
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
T
---------
52
PsiBlast_CBE
73.16
34%
-83
- C2 -
2C6Q
3
GMPR2_HUMAN
F:
[20-346]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
----
S
-
F
S
F
R
NSKQTYSG
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
HGL
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
MAMKK
Y
A
G
---
G
VA
E
Y
----
R
A
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
----------
103
PsiBlast_CBE
73.01
31%
-85
- C2 -
4IX2
2
?
A:
[14-333]
-------
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
D
L
R
T
R
L
T
K
N
-
I
A
L
N
--------
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
-
I
E
Q
-------
Q
A
-----------------------
A
Q
V
H
Q
V
K
I
S
--
G
G
L
R
--------------------------------------------------------------------------------------------------
V
G
--------------
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
D
--
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
---------------------P---
E
G
I
E
G
R
---
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
100
PsiBlast_CBE
72.77
31%
-85
- C2 -
4IX2
2
?
D:
[14-333]
-------
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
D
L
R
T
R
L
T
K
N
-
I
A
L
N
--------
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
-
I
E
Q
-------
Q
A
-----------------------
A
Q
V
H
Q
V
K
I
S
--
G
G
L
R
--------------------------------------------------------------------------------------------------
V
G
--------------
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
D
--
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
YGI
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
RG
M
---------------------P---
E
G
I
E
G
R
---
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
54
PsiBlast_CBE
72.61
34%
-82
- C2 -
2C6Q
3
GMPR2_HUMAN
D:
[20-346]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
----
S
-
F
S
F
R
NSKQTYSG
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
HGL
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
MAMKK
Y
A
G
---
G
VA
E
Y
----
R
A
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
----------
60
PsiBlast_CBE
72.37
34%
-82
- C2 -
2BZN
1
GMPR2_HUMAN
E:
[20-346]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
----
S
-
F
S
F
R
NSKQTYSG
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
HGL
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
MAMKK
Y
A
---------------
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
----------
97
PsiBlast_CBE
72.11
31%
-90
- C2 -
4QQ3
3
?
A:
[14-333]
-------
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
D
L
R
T
R
L
T
K
N
-
I
A
L
N
--------
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
-
I
E
Q
-------
Q
A
-----------------------
A
Q
V
H
Q
V
K
I
S
--
G
G
L
R
--------------------------------------------------------------------------------------------------
V
G
--------------
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
--
G
V
D
--
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
-------
G
R
S
Y
K
A
Y
R
G
M
G
-----------------------------
R
---
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
K
-
A
Q
F
V
R
I
S
G
A
------
10
PsiBlast_PDB
72.07
34%
-82
- C2 -
2C6Q
3
GMPR2_HUMAN
A:
[20-346]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
T
R
----
S
-
F
S
F
R
NSK
Q
T
Y
S
G
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
H
Y
S
-
L
V
Q
-------
W
Q
-----------------------
E
F
A
G
Q
N
P
-
D
CL
E
H
L
A
--------------------------------------------------------------------------------------------------
A
S
--------------
S
G
T
G
S
S
D
F
E
Q
--
L
E
Q
I
L
E
A
--
I
P
Q
VK
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
H
G
L
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
E
M
A
M
K
K
Y
A
G
---
G
VA
E
Y
----
R
A
S
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
T
-
T
F
I
R
V
----------
121
HHSearch
70.24
33%
-95
- C2 -
3USB
4
?
A:
[31-493]
---
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
L
S
-
E
S
L
Q
L
N
--------
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
-
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
R
SESGVIS
D
P
F
F
L
T
PEHQV
Y
D
A
E
H
L
M
G
K
Y
R
-
I
--
S
G
V
P
V
V
NNLDERKLV
G
I
I
T
N
R
D
M
R
F
IQDYSIKISDVMTK
E
Q
L
I
T
A
P
VGTT
L
S
E
A
E
K
I
L
Q
K
YKIE
K
L
P
L
V
D
NNGVLQ
G
L
I
T
I
K
D
I
E
K
V
I
E
F
PN
S
A
K
D
KQG
R
L
L
V
G
--------------
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
--
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
--
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
---
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
--------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
----
66
PsiBlast_CBE
69.65
32%
-75
- C2 -
2BWG
2
GMPR1_HUMAN
B:
[32-358]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
S
L
K
S
R
A
E
V
D
L
E
R
----
T
-
F
T
F
R
NSK
Q
T
Y
S
G
I
P
I
I
V
A
N
M
D
T
V
G
T
F
E
M
A
A
V
M
S
Q
H
S
M
F
T
A
I
H
K
H
Y
S
-
L
D
D
-------
W
K
-----------------------
L
F
A
T
N
H
P
-
E
--
C
L
Q
N
--------------------------------------------------------------------------------------------------
V
A
--------------
V
S
S
G
S
G
Q
N
D
L
E
K
M
T
S
I
L
E
A
--
V
P
Q
VK
F
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
L
V
R
A
K
F
P
E
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
V
G
P
G
S
V
C
T
T
R
T
K
T
G
V
G
Y
--
P
Q
L
S
A
V
I
E
C
A
D
S
A
H
G
L
K
G
---
H
I
I
S
D
G
G
C
T
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
F
S
G
H
T
E
C
A
G
E
V
I
----
R
K
L
K
L
F
--
Y
G
M
S
S
D
-----
T
A
M
---
N
--
K
H
VAEY
R
A
S
E
G
K
T
V
E
V
P
Y
K
G
D
V
E
N
T
I
L
D
I
L
G
G
L
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
A
-
T
F
I
R
V
T
---------
65
PsiBlast_CBE
69.49
32%
-76
- C2 -
2BWG
2
GMPR1_HUMAN
C:
[32-358]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
S
L
K
S
R
A
E
V
D
L
E
R
----
T
-
F
T
F
R
NSKQTYSG
I
P
I
I
V
A
N
M
D
T
V
G
T
F
E
M
A
A
V
M
S
Q
H
S
M
F
T
A
I
H
K
H
Y
S
-
L
D
D
-------
W
K
-----------------------
L
F
A
T
N
H
P
-
E
--
C
L
Q
N
--------------------------------------------------------------------------------------------------
V
A
--------------
V
S
S
G
S
G
Q
N
D
L
E
K
M
T
S
I
L
E
A
--
V
P
Q
VK
F
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
L
V
R
A
K
F
P
E
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
V
G
P
G
S
V
C
T
T
R
T
K
T
G
V
G
Y
--
P
Q
L
S
A
V
I
E
C
A
D
S
A
HGL
K
G
---
H
I
I
S
D
G
G
C
T
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
F
S
G
H
T
E
C
A
G
E
V
I
----
R
K
L
K
L
F
--
Y
G
M
S
S
D
-----
T
A
M
---
N
--
K
H
VAEY
R
A
S
E
G
K
T
V
E
V
P
Y
K
G
D
V
E
N
T
I
L
D
I
L
G
G
L
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
A
-
T
F
I
R
V
T
---------
64
PsiBlast_CBE
69.18
32%
-77
- C2 -
2BWG
2
GMPR1_HUMAN
D:
[32-358]
-------
L
D
F
K
D
V
L
L
R
P
K
R
S
S
L
K
S
R
A
E
V
D
L
E
R
----
T
-
F
T
F
R
NSKQTYSG
I
P
I
I
V
A
N
M
D
T
V
G
T
F
E
M
A
A
V
M
S
Q
H
S
M
F
T
A
I
H
K
H
Y
S
-
L
D
D
-------
W
K
-----------------------
L
F
A
T
N
H
P
-
E
--
C
L
Q
N
--------------------------------------------------------------------------------------------------
V
A
--------------
V
S
S
G
S
G
Q
N
D
L
E
K
M
T
S
I
L
E
A
--
V
P
Q
VK
F
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
L
V
R
A
K
F
P
E
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
V
G
P
G
S
V
C
T
T
R
T
K
T
G
V
G
Y
--
P
Q
L
S
A
V
I
E
C
A
D
S
A
HGL
K
G
---
H
I
I
S
D
G
G
C
T
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
F
S
G
H
T
E
C
A
G
E
V
I
----
R
K
L
K
L
F
--
Y
G
M
S
S
D
-----
T
A
M
---
N
--
K
H
AEY-
R
A
S
E
G
K
T
V
E
V
P
Y
K
G
D
V
E
N
T
I
L
D
I
L
G
G
L
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
R
R
A
-
T
F
I
R
V
T
---------
126
HHSearch
61.42
31%
-78
- C2 -
2CU0
1
IMDH_PYRHO
A:
[12-469]
----
I
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
-
P
K
D
V
D
V
S
T
R
I
T
P
N
-
V
K
L
N
--------
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
-
N
M
G
I
E
E
Q
V
E
Q
---
V
K
R
V
K
R
AE------------------------------------------------------------------------------------------------------------------------------------KYKN
A
V
R
D
ENG
E
L
L
V
A
A
A
V
S
P
F
D
I
K
R
A
I
E
L
D
K
A
--
G
V
D
--
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
-
D
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
--
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
Y
G
L
---
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
--
R
G
M
G
S
L
G
A
---
M
M
K
YMK
T
--
R
K
----
F
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
-
K
E
K
G
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
20
PsiBlast_PDB
59.82
39%
-88
- C2 -
3TSD
1
?
A:
[245-479]
-------------------------------------------------------------------------------------------------------------------------------------
L
L
--------------------------------------------------------------------------------------------------
V
G
--------------
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
--
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
------
R
Q
F
K
V
Y
--
R
G
------------------------------
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
E
N
-
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
93
PsiBlast_CBE
58.86
39%
-85
- C2 -
3TSD
1
?
B:
[245-479]
-------------------------------------------------------------------------------------------------------------------------------------
L
L
--------------------------------------------------------------------------------------------------
V
G
--------------
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
--
S
V
D
--
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
-----
G
R
Q
F
K
V
Y
--
R
G
M
----------------------------
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
E
N
-
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
124
HHSearch
39.65
36%
-57
- C2 -
1ZFJ
1
IMDH_STRPY
A:
[234-477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
E
R
A
E
A
L
F
E
A
--
G
A
D
--
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
--
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
Y
G
K
---
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
--
R
G
M
G
S
I
AA---
M
K
K
------
N
K
----
L
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
-
H
E
N
A
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P