@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1165: (2015-12-05 )
MIYLDNAATTALTPSVIEKMTNVMTSNYGNPSSIHTFGRQANQLLRECRQIIAEYLNVNSREIIFTSGGTESNNTAIKGYALANQLKGKHIITSEIEHHSVLHTMTYLSERFGFDITYLKPNHGQITAKDVQEALRDDTIMVSLMFANNETGDFLPIQEIGQLLRNHQAVFHVDAVQVFSKMELDPHSLGIDFLAASAHKFHGPKGVGILYCAPHHFDSLLHGGDQEEKRRASTENIIGIAGMSQALTDATTNTLKNWTHISQLRTTFLDAISDLDFYLNNGQDCLPHVLNIGFPRQNNGLLLTQLDLAGFAVSTGSACTAGTVEPSHVLTSLYGANSPRLNESIRISFSELNTQEEILELAKTLRKIIGD
Atome Classification :
(27 SA)
-.........10........20......--..30-..-......40........50........60.........70...----.....80.---...------...--.-----90--.........100.......110.......120.--.--......130....--...140.......150.......160..--.--.----------.----------..170------.........180.......190.......200.......210-----.------...-.--------.--------..220....----------------.---....230.......240.......250.......260.-----......270-..-.-..-----..280---.-.-----.-.---....290-....-.-..--.300........310.......320-..-.-....330.......340.......350.......360.......370------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
I
YLDNAATTAL
T
P
S
V
I
E
K
M
T
N
V
M
TSN--YG
N
P
-
S
S
-
I
H
T
F
G
R
Q
A
N
Q
L
L
R
E
C
R
Q
I
I
A
E
Y
LNVNS-
R
E
I
I
F
TSGGTESNN----
T
A
I
K
G
Y
A
L
---
A
N
Q------LKG--
K
-----
H
---
I
I
T
S
E
I
E
H
H
S
V
L
H
T
M
T
Y
L
S
E
RFGF
D
I
T
Y
L
K-PN--H--G
Q
I
T
A
K
D
V
Q
E
A
LR--DD
T
I
M
V
S
L
M
F
ANNETGDFL
P
I
Q
E
I
G
Q
L
L
--
R
--N----------H----------Q
A
V
--------
F
H
V
D
A
V
Q
V
F
S
K
MEL
D
P
H
S
L
G
I
D
F
L
A
A
S
AHKFHGPK
G
V
G
I
L
Y
------C------A
P
H
-
H
--------
F
--------
D
S
L
--LHGG----------------
D
---
Q
E
E
K
RRASTE
N
I
I
GIA
G
M
S
Q
A
L
T
D
A
T
T
N
T
L
K
N
W
T
H
I
S
Q
-----
L
R
T
T
F
L
D
A
I
-
S
D
-
L
-
D
F
-----YLN-N---G-
Q
-----
D
-
C
---
L
P
H
V
L
N--IGFP-R-QN--N
G
-
L
L
L
T
Q
LDL
A
G
F
A
VSTGSACTAG-TV-
E
-
P
S
H
V
L
T
S
L
YGANSPRLN
E
S
I
R
I
S
F
S
ELN
T
Q
E
E
I
L
E
L
A
K
T
L
R
K
I
IGD-------
1
PsiBlast_PDB
94.28
41%
-85
- C1 -
3LVJ
2
ISCS_ECO57
A:
[24-397]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
M
D
GT
F
G
N
P
-
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
-
R
E
I
V
F
T
S
G
A
T
E
S
D
N
----
L
A
I
K
G
A
A
N
---
F
Y
Q
------
K
K
G
--
K
-----
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
G
F
E
V
T
Y
L
A
-
P
Q
--
R
N-
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
--
R
--
A
----------
R
----------
G
I
I
--------
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
------
V
R
R----
K
P
R
V
R
--------
I
--------
E
A
Q
--
M
H
G
G
----------------
G
---
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
M
A
T
E
M
E
R
L
R
G
-----
L
R
N
R
L
W
N
G
I
-
K
D
-
I
E
E
V
-----
Y
L
N
-
G
---
D
L
E
-----
H
-
G
---
A
P
N
I
L
N
--
V
S
F
N
-
Y
V
E
G
--
E
S
-
L
I
M
A
L
K
D
L
---
A
V
S
S
G
-------
S
L
-
E
-
P
S
Y
V
L
R
A
L
-
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
-------
2
PsiBlast_PDB
93.47
41%
-85
- C1 -
3LVK
1
ISCS_ECO57
A:
[24-397]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
M
D
GT
F
G
N
P
-
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
-
R
E
I
V
F
T
S
G
A
T
E
S
D
N
----
L
A
I
K
G
A
A
N
---
F
Y
Q
------
K
K
G
--
K
-----
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
G
F
E
V
T
Y
L
A
-
P
Q
--
R
N-
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
--
R
--
A
----------
R
----------
G
I
I
--------
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
------
V
R
R----
K
P
R
V
R
--------
I
--------
E
A
Q
--
M
H
G
G
----------------
G
---
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
M
A
T
E
M
E
R
L
R
G
-----
L
R
N
R
L
W
N
G
I
-
K
D
-
I
E
E
V
-----
Y
L
N
-
G
---
D
L
E
-----
H
-
G
---
A
P
N
I
L
N
--
V
S
F
N
-
Y
V
E
G
--
E
S
-
L
I
M
A
L
K
D
L
---
A
V
S
S
G
S
A
C
-----
L
-
E
-
P
S
Y
V
L
R
A
L
-
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
-------
21
PsiBlast_CBE
91.52
41%
-87
- C1 -
3LVJ
2
ISCS_ECO57
B:
[24-397]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
M
D
GT
F
G
N
P
-
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
-
R
E
I
V
F
T
S
G
A
T
E
S
D
N
----
L
A
I
K
G
A
A
N
---
F
Y
Q
------
K
K
G
--
K
-----
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
G
F
E
V
T
Y
L
A
-
P
Q
--
R
N-
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
--
R
--
A
----------
R
----------
G
I
I
--------
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
------
V
RR----
K
P
R
V
R
--------
I
--------
E
A
Q
--
M
H
G
G
----------------
G
---
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
M
A
T
E
M
E
R
L
R
G
-----
L
R
N
R
L
W
N
G
I
-
K
D
-
I
E
E
V
-----
Y
L
N
-
G
---
D
L
E
-----
H
-
G
---
A
P
N
I
L
N
--
V
S
F
N
-
Y
V
E
G
--
E
S
-
L
I
M
A
L
K
D
L
---
A
V
S
S
G
S
A
C
-----
L
-
E
-
P
S
Y
V
L
R
A
L
-
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
-------
32
HHSearch
88.62
35%
-91
- C1 -
1EG5
3
?
A:
[2-374]
-
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
--
Y
G
N
P
-
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
-
S
E
I
F
F
T
S
C
A
T
E
S
I
N
----
W
I
L
K
T
V
A
E
---
T
F
-------
E
K
R
K-
R
-----
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
G
F
K
V
K
Y
V
P
-
V
D
S-
R
--
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
--
K
--
K
----------
K
NK--------
E
T
L
--------
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
------
I
------
R
K
G
V
P
--------
I
--------
R
P
L
--
I
H
G
G
----------------
G
---
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
-----
L
R
S
K
L
V
S
G
L
-
M
N
-
L
-
G
A
-----
H
I
I
-
T
---
P
L
E
-----
I
-
S
---
L
P
N
T
L
S
--
V
S
F
P
-
N
-
I
R
--
G
S
-
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
---------------
H
V
L
D
A
M
G
-
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
-------
55
Fugue
88.21
35%
-91
* C1 *
1ECX
2
?
A:
[1-376]
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
--
Y
G
N
P
-
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
-
S
E
I
F
F
T
S
C
A
T
E
S
I
N
----
W
I
L
K
T
V
A
E
---
T
F
E
------
K
R
K
--
R
-----
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
K
-
G
F
K
V
K
Y
V
P
-
V
D
S-
R
--
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
--
K
--
K
----------
K
NK--------
E
T
L
--------
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
------
I
------
R
K
G
V
P
--------
I
--------
R
P
L
--
I
H
G
G
----------------
G
---
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
-----
L
R
S
K
L
V
S
G
L
-
M
N
-
L
-
G
A
-----
H
I
I
-
T
---
P
-
L
-----
E
I
S
---
L
P
N
T
L
S
--
V
S
F
P
-
N
-
I
R
--
G
S
-
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
---------------
T
H
V
L
D
A
M
-
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L------
3
PsiBlast_PDB
87.73
35%
-91
- C1 -
1ECX
2
?
A:
[3-373]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
--
Y
G
N
P
-
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
-
S
E
I
F
F
T
S
C
A
T
E
S
I
N
----
W
I
L
K
T
V
A
E
---
T
F
E
------
K
R
K
--
R
-----
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
K
-
G
F
K
V
K
Y
V
P
-
V
D
S-
R
--
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
K
--
N
----------
K
----------
E
T
L
--------
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
------
I
------
R
K
G
V
P
--------
I
--------
R
P
L
--
I
H
G
G
----------------
G
---
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
-----
L
R
S
K
L
V
S
G
L
-
M
N
-
L
-
G
A
-----
H
I
I
-
T
---
P
-
L
-----
E
I
S
---
L
P
N
T
L
S
--
V
S
F
P
-
N
-
I
R
--
G
S
-
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
---------------
H
V
L
D
A
M
-
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
-------
22
PsiBlast_CBE
87.50
35%
-91
- C1 -
1ECX
2
?
B:
[3-373]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
--
Y
G
N
P
-
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
-
S
E
I
F
F
T
S
C
A
T
E
S
I
N
----
W
I
L
K
T
V
A
E
---
T
F
E
------
K
R
K
--
R
-----
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
K
-
G
F
K
V
K
Y
V
P
-
V
D
S-
R
--
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
KK
K
--
N
----------
K
----------
E
T
L
--------
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
------
I
------
R
K
G
V
P
--------
I
--------
R
P
L
--
I
H
G
G
----------------
G
---
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
-----
L
R
S
K
L
V
S
G
L
-
M
N
-
L
-
G
A
-----
H
I
I
-
T
---
P
-
L
-----
E
I
S
---
L
P
N
T
L
S
--
V
S
F
P
-
N
-
I
R
--
G
S
-
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
R
H
V
L
D
A
M
-
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
-------
57
Fugue
86.76
35%
-86
- C1 -
4ISY
3
ISCSL_MYCTU
A:
[12-398]
-
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
T
---
I
G
N
A
-
S
S
-
L
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
-
S
E
V
I
F
T
A
G
G
T
E
S
D
N
----
L
A
V
K
G
I
Y
W
---
A
R
R
------
D
A
E
--
P
-----
H
RR
R
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
E
G
A
H
V
T
W
L
P
T
A
A
--
D
--
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
--
M
--
E
----------
F
----------
G
V
P
--------
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
------
L
------
R
R
D
V
T
--------
C
--------
V
P
L
--
M
H
G
G
----------------
G
---
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
-----
L
R
D
R
L
V
E
G
V
-
L
A
E
I
-
D
D
-----
V
C
L
-
N
---
G
-
A
-----
D
-
D
PMR
L
A
G
N
A
H
--
F
T
F
R
-
G
-
C
E
--
G
D
-
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
-----------
P
S
H
V
L
I
A
M
-
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
ALA
8
PsiBlast_PDB
85.62
34%
-89
- C1 -
1EG5
3
?
A:
[3-373]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
--
Y
G
N
P
-
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
-
S
E
I
F
F
T
S
C
A
T
E
S
I
N
----
W
I
L
K
T
V
A
E
---
T
F
E
------
K
R
K
--
R
-----
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
K
-
G
F
K
V
K
Y
V
P
-
V
D
S-
R
--
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
K
--
N
----------
K
----------
E
T
L
--------
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
------
I
------
R
K
G
V
P
--------
I
--------
R
P
L
--
I
H
G
G
----------------
G
---
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
-----
L
R
S
K
L
V
S
G
L
-
M
N
-
L
-
G
A
-----
H
I
I
-
T
---
P
-
L
-----
E
I
S
---
L
P
N
T
L
S
--
V
S
F
P
-
N
-
I
R
--
G
S
-
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
---------------
H
V
L
D
A
M
-
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
-------
18
PsiBlast_PDB
82.42
25%
-97
- C1 -
1JF9
1
SUFS_ECOLI
A:
[26-403]
-
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
I
D
A
E
A
E
F
Y
R
H
G
--
Y
A
A
V
H
R
G
-
I
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
R
S
A
E
E
L
V
F
V
R
G
T
T
E
G
I
N
----
L
V
A
N
S
W
G
N
---
S
N
V
------
R
A
G
--
D
-----
N
---
I
I
I
S
Q
M
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
R
V
G
A
E
L
R
V
I
P
-
L
N
P-
D
--
G
T
L
Q
L
E
T
L
P
T
L
F
D
--
E
K
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
--
H
--
Q
----------
H
----------
G
A
K
--------
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
K
L
Y
G
P
T
G
I
G
I
L
Y
------
V
------
K
E
A
-
L
--------
L
--------
Q
E
M
PP
W
E
G
G
GSMIATVSLSE
G
T
T
W
T
K
---
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
G
L
N
N
I
A
E
Y
E
Q
N
L
M
H
-
Y
A
L
S
Q
L
E
S
V
-
P
D
-
L
-
T
L
-----
Y
-------
G
-
P
-----
Q
-
N
---
R
L
G
V
I
A
--
F
N
L
G
-
K
-
H
H
--
A
Y
-
D
V
G
S
F
L
D
N
Y
G
I
A
V
R
T
G
H
H
C
----------
A
M
P
L
M
A
Y
Y
--
N
V
P
A
M
---
C
R
A
S
L
A
M
Y
N
T
H
E
E
V
D
R
L
V
T
G
L
Q
R
I
H
R
L
-------
11
PsiBlast_PDB
82.30
32%
-78
- C1 -
3GZD
3
SCLY_HUMAN
C:
[27-433]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
M
T
K
A
M
W
E
A
--
W
G
N
P
-
S
S
-
P
Y
S
A
G
R
K
A
K
D
I
I
N
A
A
R
E
S
L
A
K
M
I
G
G
K
P
-
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
----
L
V
I
H
S
V
V
K
HFH
A
N
Q
TS------
G
AK
P
-----
H
---
F
I
T
S
S
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
E
Q
V
A
A
V
T
F
V
P
-
V
S
--
K
VS
G
Q
T
E
V
D
D
I
L
A
A
V
R
--
P
T
T
R
L
V
T
I
M
L
A
N
N
E
T
G
I
V
M
P
V
P
E
I
S
Q
R
I
--
K
AL
N
----------
Q
----------
E
R
V
AAGLPPIL
V
H
T
D
A
A
Q
A
L
G
K
Q
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
------
I
RGLGEF
T
P
L
-
Y
------------------
P
M
--
L
F
G
G
----------------
G
---
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
E
L
V
T
Q
N
C
E
A
Y
E
A
H
M
R
D
-----
V
R
-
D
Y
L
E
E
R
-
L
E
-
A
-
E
F
GQKRI
H
L
N
-
S
QFP
G
-
T
-----
Q
-
R
---
L
P
N
T
C
N
FS
I
R
G
P
-
R
-
L
Q
--
G
H
-
V
V
L
A
Q
C
R
V
--
L
M
A
S
V
G
A
A
C
-----
D
-
Q
-
P
S
P
V
L
L
S
-
Y
G
V
P
F
D
V
A
R
N
A
L
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
V
V
Q
D
L
K
Q
A
V
A
Q
-------
6
PsiBlast_PDB
82.20
32%
-88
- C1 -
4HVK
12
ISCS2_ARCFU
A:
[2-370]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
S
--
F
G
N
P
-
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
-
G
T
V
V
F
T
S
G
A
T
E
A
N
N
----
L
A
I
I
G
Y
A
M
---
R
N
A
------
R
K
G
--
K
-----
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
--
Y
--
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
--
A
--
G
---------------------
K
A
A
--------
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
------
I
------
R
K
E
A
K
--------
L
--------
Q
P
V
--
I
L
G
G
----------------
G
---
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
----
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
L
-
K
I
-
E
-
E
S
-----
Y
L
N
G
H
---
P
-
E
-----
K
-
R
---
L
P
N
N
V
N
--
V
R
F
S
-
Y
-
I
E
--
G
E
-
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
----------
Q
-
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
-------
5
PsiBlast_PDB
81.96
32%
-86
- C1 -
4EB7
7
ISCS2_ARCFU
A:
[2-370]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
S
--
F
G
N
P
-
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
-
G
T
V
V
F
T
S
G
A
T
E
A
N
N
----
L
A
I
I
G
Y
A
M
---
R
N
A
------
R
K
G
--
K
-----
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
--
Y
--
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
--
A
--
G
---------------------
K
A
A
--------
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
------
I
------
R
K
E
A
K
--------
L
--------
Q
P
V
--
I
L
G
G
----------------
G
---
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
----
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
L
-
K
I
-
E
-
E
S
-----
Y
L
N
G
H
---
P
-
E
-----
K
-
R
---
L
P
N
N
V
N
--
V
R
F
S
-
Y
-
I
E
--
G
E
-
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
--
T
L
-
Q
-
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
-------
25
PsiBlast_CBE
81.73
36%
-78
- C1 -
4ISY
1
ISCSL_MYCTU
D:
[14-378]
---
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
T
---
I
G
N
A
-
S
S
-
L
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
-
S
E
V
I
F
T
A
G
G
T
E
S
D
N
----
L
A
V
K
G
I
Y
W
---
A
R
R
------
D
A
E
--
P
-----
H
RRR
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
E
G
A
H
V
T
W
L
P
T
A
A
--
D
--
G
S
V
S
A
T
A
L
R
E
A
L
Q
SH
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
--
M
--
E
----------
F
----------
G
V
P
--------
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
LRRDVT
C
------
V
P
----------------------
L
--
M
H
G
G
----------------
G
---
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
-----
L
R
D
R
L
V
E
G
V
L
A
E
-
I
D
D
V
-----
C
L
N
-
G
---
A
-
D
-----
D
-
P
---
M
R
L
A
G
N
--
A
H
F
T
F
R
-
G
C
--
E
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
-----------
P
S
H
V
L
I
A
M
-
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
-------
30
PsiBlast_CBE
81.10
32%
-77
- C1 -
3GZD
3
SCLY_HUMAN
B:
[27-433]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
M
T
K
A
M
W
E
A
--
W
G
N
P
-
S
S
-
P
Y
S
A
G
R
K
A
K
D
I
I
N
A
A
R
E
S
L
A
K
M
I
G
G
K
P
-
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
----
L
V
I
H
S
V
V
K
HFH
A
N
Q
TS------
G
AK
P
-----
H
---
F
I
T
S
S
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
E
Q
V
A
A
V
T
F
V
P
-
V
S
--
K
VS
G
Q
T
E
V
D
D
I
L
A
A
V
R
--
P
T
T
R
L
V
T
I
M
L
A
N
N
E
T
G
I
V
M
P
V
P
E
I
S
Q
R
I
--
K
AL
N
----------
Q
----------
E
R
V
AAGLPPIL
V
H
T
D
A
A
Q
A
L
G
K
Q
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
------
I
RGLGEF
T
P
L
-
Y
------------------
P
M
--
L
F
G
G
----------------
G
---
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
E
L
V
T
Q
N
C
E
A
Y
E
A
H
M
R
D
-----
V
R
-
D
Y
L
E
E
R
-
L
E
-
A
-
E
F
GQKRI
H
L
N
-
S
QFP
G
-
T
-----
Q
-
R
---
L
P
N
T
C
N
FS
I
R
G
P
-
R
-
L
Q
--
G
H
-
V
V
L
A
Q
C
R
V
--
L
M
A
S
V
G
----------
Q
-
P
S
P
V
L
L
S
-
Y
G
V
P
F
D
V
A
R
N
A
L
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
V
V
Q
D
L
K
Q
A
V
A
Q
-------
19
PsiBlast_PDB
81.08
25%
-96
- C1 -
1I29
2
SUFS_ECOLI
A:
[24-401]
-
L
A
Y
L
D
S
A
A
S
A
Q
K
P
S
Q
V
I
D
A
E
A
E
F
Y
R
H
G
--
Y
A
A
V
H
R
G
-
I
H
T
L
S
A
Q
A
T
E
K
M
E
N
V
R
K
R
A
S
L
F
I
N
A
R
S
A
E
E
L
V
F
V
R
G
T
T
E
G
I
N
----
L
V
A
N
S
W
G
N
---
S
N
V
------
R
A
G
--
D
-----
N
---
I
I
I
S
Q
M
E
H
H
A
N
I
V
P
W
Q
M
L
C
A
R
V
G
A
E
L
R
V
I
P
-
L
N
P-
D
--
G
T
L
Q
L
E
T
L
P
T
L
F
D
--
E
K
T
R
L
L
A
I
T
H
V
S
N
V
L
G
T
E
N
P
L
A
E
M
I
T
L
A
--
H
--
Q
----------
H
----------
G
A
K
--------
V
L
V
D
G
A
Q
A
V
M
H
H
P
V
D
V
Q
A
L
D
C
D
F
Y
V
F
S
G
H
K
L
Y
G
P
T
G
I
G
I
L
Y
------
V
------
K
E
A
-
L
--------
L
--------
Q
E
M
PP
W
E
G
G
GSMIATVSLSE
G
T
T
W
T
K
---
A
P
W
R
F
E
A
G
T
P
N
T
G
G
I
I
G
L
G
A
A
L
E
Y
V
S
A
L
G
L
N
N
I
A
E
Y
E
Q
N
L
M
H
-
Y
A
L
S
Q
L
E
S
V
-
P
D
-
L
-
T
L
-----
Y
-------
G
-
P
-----
Q
-
N
---
R
L
G
V
I
A
--
F
N
L
G
-
K
-
H
H
--
A
Y
-
D
V
G
S
F
L
D
N
Y
G
I
A
V
R
T
G
H
H
C
----------
A
M
P
L
M
A
Y
Y
--
N
V
P
A
M
---
C
R
A
S
L
A
M
Y
N
T
H
E
E
V
D
R
L
V
T
G
L
Q
R
I
H
R
L
-------
23
PsiBlast_CBE
80.80
32%
-87
- C1 -
4EB7
4
ISCS2_ARCFU
B:
[2-370]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
S
--
F
G
N
P
-
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
-
G
T
V
V
F
T
S
G
A
T
E
A
N
N
----
L
A
I
I
G
Y
A
M
---
R
N
A
------
R
K
G
--
K
-----
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
--
Y
--
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
--
A
--
G
---------------------
K
A
A
--------
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
------
I
------
R
K
E
A
K
--------
L
--------
Q
P
V
--
I
L
G
G
----------------
G
---
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
----
A
A
E
I
T
A
M
E
W
R
E
E
A
E
RLRRL
R
D
R
I
I
D
N
V
L
-
K
I
-
E
-
E
S
-----
Y
L
N
G
H
---
P
-
E
-----
K
-
R
---
L
P
N
N
V
N
--
V
R
F
S
-
Y
-
I
E
--
G
E
-
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
-
T
L
-
Q
-
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
-------
4
PsiBlast_PDB
80.51
32%
-85
- C1 -
4EB5
6
ISCS2_ARCFU
A:
[2-370]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
S
--
F
G
N
P
-
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
-
G
T
V
V
F
T
S
G
A
T
E
A
N
N
----
L
A
I
I
G
Y
A
M
---
R
N
A
------
R
K
G
--
K
-----
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
--
Y
--
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
--
A
--
G
---------------------
K
A
A
--------
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
------
I
------
R
K
E
A
K
--------
L
--------
Q
P
V
--
I
L
G
G
----------------
G
---
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
----
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
L
-
K
I
-
E
-
E
S
-----
Y
L
N
G
H
---
P
-
E
-----
K
-
R
---
L
P
N
N
V
N
--
V
R
F
S
-
Y
-
I
E
--
G
E
-
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
-
T
L
-
Q
-
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
-------
10
PsiBlast_PDB
80.29
32%
-77
- C1 -
3GZC
2
SCLY_HUMAN
A:
[27-433]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
M
T
K
A
M
W
E
A
--
W
G
N
P
-
S
S
-
P
Y
S
A
G
R
K
A
K
D
I
I
N
A
A
R
E
S
L
A
K
M
I
G
G
K
P
-
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
----
L
V
I
H
S
V
V
K
H
F
H
A
N
Q
T-------
G
A
K
P
-----
H
---
F
I
T
S
S
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
E
Q
V
A
A
V
T
F
V
P
-
V
S
--
K
VS
G
Q
T
E
V
D
D
I
L
A
A
V
R
--
P
T
T
R
L
V
T
I
M
L
A
N
N
E
T
G
I
V
M
P
V
P
E
I
S
Q
R
I
--
K
A
L
N
----------
Q
----------
E
R
V
A
A
G
L
P
P
I
L
V
H
T
D
A
A
Q
A
L
G
K
Q
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
------
I
R
GLGEF
T
P
L
-
Y
------------------
P
M
--
L
F
G
G
----------------
G
---
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
E
L
V
T
Q
N
C
E
A
Y
E
A
H
M
R
D
-----
V
R
-
D
Y
L
E
E
R
-
L
E
-
A
-
E
F
GQKRI
H
L
N
-
S
QFP
G
-
T
-----
Q
-
R
---
L
P
N
T
C
N
F
S
I
R
G
P
-
R
-
L
Q
--
G
H
-
V
V
L
A
Q
C
R
V
--
L
M
A
S
V
G
A
A
C
H
S
D
H
G
D
-
Q
-
P
S
P
V
L
L
S
-
Y
G
V
P
F
D
V
A
R
N
A
L
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
V
V
Q
D
L
K
Q
A
V
A
Q
-------
7
PsiBlast_PDB
80.18
36%
-79
- C1 -
4ISY
3
ISCSL_MYCTU
A:
[14-378]
---
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
T
---
I
G
N
A
-
S
S
-
L
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
-
S
E
V
I
F
T
A
G
G
T
E
S
D
N
----
L
A
V
K
G
I
Y
W
---
A
R
R
------
D
A
E
--
P
-----
H
RR
R
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
E
G
A
H
V
T
W
L
P
T
A
A
--
D
--
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
--
M
--
E
----------
F
----------
G
V
P
--------
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
RR
D
V
T
C
------
V
P
----------------------
L
--
M
H
G
G
----------------
G
---
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
-----
L
R
D
R
L
V
E
G
V
L
A
E
-
I
D
D
V
-----
C
L
N
-
G
---
A
-
D
-----
D
-
P
---
M
R
L
A
G
N
--
A
H
F
T
F
R
-
G
C
--
E
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
-----------
P
S
H
V
L
I
A
M
-
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
-------
24
PsiBlast_CBE
80.01
32%
-89
- C1 -
4EB5
5
ISCS2_ARCFU
B:
[2-370]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
S
--
F
G
N
P
-
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
-
G
T
V
V
F
T
S
G
A
T
E
A
N
N
----
L
A
I
I
G
Y
A
M
---
R
N
A
------
R
K
G
--
K
-----
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
--
Y
--
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
--
A
--
G
---------------------
K
A
A
--------
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
------
I
------
R
K
E
A
K
--------
L
--------
Q
P
V
--
I
L
G
G
----------------
G
---
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
----
A
A
E
I
T
A
M
E
W
R
E
E
A
E
RLRRL
R
D
R
I
I
D
N
V
L
-
K
I
-
E
-
E
S
-----
Y
L
N
G
H
---
P
-
E
-----
K
-
R
---
L
P
N
N
V
N
--
V
R
F
S
-
Y
-
I
E
--
G
E
-
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
-
T
L
-
Q
-
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
-------
9
PsiBlast_PDB
79.94
35%
-78
- C1 -
3VAX
1
?
A:
[22-379]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
A
E
--
F
G
N
A
-
G
S
-
R
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
-
D
E
L
I
F
T
S
G
A
T
E
S
N
N
----
I
A
L
L
G
L
A
P
---
Y
G
E
------
R
T
G
R-
R
-----
H
---
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
A
G
R
-
G
F
E
V
D
F
L
T
-
P
G
P-
S
--
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
--
R
--
A
----------
T
----------
P
T
Y
--------
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
-
L
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
------
T
------
R
R
R
-
E
EMDDERVP
L
--------
E
P
I
--
M
F
G
G
----------------
G
---
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
H
A
Q
W
Q
V
A
A
Q
D
-----
L
R
S
R
L
L
A
G
L
-
A
S
-
T
-
S
F
-----
Q
V
N
-
G
---
D
-
Q
-----
D
H
V
---
V
P
H
I
L
N
--
L
S
F
E
-
D
-
V
D
A
-
E
A
-
F
L
V
T
L
K
D
L
--
V
A
V
A
T
G
S
A
S
T
S
A
-
S
F
-
T
-
P
S
H
V
L
R
A
M
-
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
28
PsiBlast_CBE
79.67
35%
-78
- C1 -
3VAX
2
?
B:
[22-379]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
A
E
--
F
G
N
A
-
G
S
-
R
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
-
D
E
L
I
F
T
S
G
A
T
E
S
N
N
----
I
A
L
L
G
L
A
P
---
Y
G
E
------
R
T
G
R-
R
-----
H
---
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
A
G
R
-
G
F
E
V
D
F
L
T
-
P
G
P-
S
--
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
--
R
--
A
----------
T
----------
P
T
Y
--------
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
-
L
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
------
T
------
R
R
R
-
E
EMDDERVP
L
--------
E
P
I
--
M
F
G
G
----------------
G
---
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
H
A
Q
W
Q
V
A
A
Q
D
-----
L
R
S
R
L
L
A
G
L
-
A
S
-
T
-
S
F
-----
Q
V
N
-
G
---
D
-
Q
-----
D
H
V
---
V
P
H
I
L
N
--
L
S
F
E
-
D
-
V
D
A-
E
A
-
F
L
V
T
L
K
D
L
--
V
A
V
A
T
G
S
A
S
T
S
A
-
S
F
-
T
-
P
S
H
V
L
R
A
M
-
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
39
HHSearch
79.42
30%
-78
- C1 -
3A9Z
5
SCLY_RAT
A:
[19-426]
-
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
E
A
--
W
G
N
P
-
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
-
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
----
L
V
I
H
S
T
V
R
---
C
F
H
E
Q
Q
T
L
Q-
T
R
--
P
-----
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
V
A
E
V
T
F
V
P
-
V
S
KV
N
--
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
--
K
--
A
----------
L
N
Q
I
R
A
A
S
GL
P
R
V
L
--------
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
------
V
------
R
G
V
G
K
--------
L
--------
T
P
L
--
Y
P
M
L
----------------
F
GGG
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
-----
I
R
D
Y
L
E
E
R
L
-
E
A
-
E
F
G
K
-----
R
I
H
-
L
---
N
-
S
RFPG
V
E
-
R
---
L
P
N
T
C
N
--
F
S
I
Q
-
G
-
S
Q
LR
G
Y
-
M
V
L
--
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
-
H
E
D
R
-
P
S
P
V
L
L
S
C
G
-
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
-------
12
PsiBlast_PDB
78.87
30%
-85
- C1 -
3A9X
3
SCLY_RAT
A:
[20-425]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
E
A
--
W
G
N
P
-
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
-
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
---
Q
Q
T
------
L
Q
G
---EG
T
R
P
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
V
A
E
V
T
F
V
P
-
V
S
KV
N
--
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
--
K
--
A
L
N
Q
I
R
A
A
S
G
L
P
----------
R
V
L
--------
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
------
V
RGVGKL
T
P
L
-
Y
------------------
P
M
--
L
F
G
G
----------------
G
---
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
-----
I
R
-
D
Y
L
E
E
R
-
L
E
-
A
-
E
F
GKRI-
H
L
N
-
S
RFP
G
-
V
-----
E
-
R
---
L
P
N
T
C
N
--
F
S
I
Q
G
S
-
Q
L
--
R
G
Y
M
V
L
A
Q
C
Q
T
--
L
L
A
S
V
G
A
----------------------
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
-------
34
HHSearch
77.17
36%
-74
- C1 -
3VAX
1
?
A:
[22-379]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
A
E
--
F
G
N
A
-
G
S
-
R
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
-
D
E
L
I
F
T
S
G
A
T
E
S
N
N
----
I
A
L
L
G
L
A
P
---
Y
G
E
------
R
T
G
R-
R
-----
H
---
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
A
-
G
R
G
F
E
V
D
F
L
T
-
P
G
P-
S
--
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
--
R
--
A
----------
T
----------
P
T
Y
--------
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
T
T
-
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
------
T
------
R
R
R
-
E
--------
E
MDDERVPL
E
P
I
--
M
F
G
G
----------------
G
---
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
H
A
Q
W
Q
V
A
A
Q
D
-----
L
R
S
R
L
L
A
G
L
-
A
S
-
T
-
S
F
-----
Q
V
N
-
G
---
D
Q
D
-----
H
-
V
---
V
P
H
I
L
N
--
L
S
F
E
-
D
-
V
D
--
A
E
-
A
F
L
V
T
L
K
-
D
L
V
A
V
A
T
G
S
A
S
T
S
A
-
S
F
-
T
-
P
S
H
V
L
R
A
M
G
-
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
13
PsiBlast_PDB
75.63
30%
-78
- C1 -
3A9Z
5
SCLY_RAT
A:
[20-425]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
E
A
--
W
G
N
P
-
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
-
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
---
Q
Q
T
------
L
Q
----T
R
P
--
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
V
A
E
V
T
F
V
P
-
V
S
KV
N
--
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
--
K
--
A
L
N
Q
I
R
A
A
S
GL
P
----------
R
V
L
--------
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
------
V
R
GVGKL
T
P
L
-
Y
------------------
P
M
--
L
F
G
G
----------------
G
---
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
-----
I
R
-
D
Y
L
E
E
R
-
L
E
-
A
-
E
F
GKRI-
H
L
N
-
S
RFP
G
-
V
-----
E
-
R
---
L
P
N
T
C
N
--
F
S
I
Q
G
S
-
Q
L
--
R
G
Y
M
V
L
A
Q
C
Q
T
--
L
L
A
S
V
G
A
S
C
H
S
D
-
H
E
-
D
R
P
S
P
V
L
L
S
C
-
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
-------