@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1178: (2015-12-06 )
MTNPIIAFKNVSKVFEDSNTVVLKDINFELEEGKFYTLLGASGSGKSTILNIIAGLLEASTGDIYLDGKRINDVPTNKRDVHTVFQNYALFPHMTVFENVAFPLKLKKMDKKEIQKRVQETLKMVRLEGFEKRAIQKLSGGQRQRVAIARAIINQPKVVLLDEPLSALDLKLRTEMQYELRELQQRLGITFVFVTHDQEEALAMSDWIFVMNEGEIVQSGTPVDIYDEPINHFVATFIGESNILSGKMIEDYLVEFNGKRFEAVDGGMRPNESVQVVIRPEDLQITLPDEGKLQVKVDTQLFRGVHYEIIAYDDLGNEWMIHSTRKAIEGEVIGLDFTPEDIHIMRLNETEEEFDARIEEYVDTDDHEDGLINAIEEERNEENL
Atome Classification :
(38 SA)
.........10........20........30........40........50........60-........70..------....----..80..--------......90........100-.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240-..------......250...----..-------..260..--.....270.--...------...280.------......290.......300.......310....-...320----.----..-------------...-----------.--330.......340.......350.......360.......370.......380..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTN
P
I
I
A
F
K
N
V
S
K
VFEDS
N
T
V
V
L
K
DI
N
F
E
LEE
G
K
F
Y
T
L
L
GASGSG
K
S
T
I
L
N
I
I
A
G
L
L
EAST-G
D
I
Y
LDGKRIND------VPTN----K
R
D
V
H
T
--------
V
F
Q
NYALFP
H
M
T
V
F
E
NVAF-
P
L
K
L
KKM
D
K
K
E
I
Q
K
R
V
Q
E
T
L
K
M
V
R
LE
G
F
E
K
R
A
I
Q
K
LSGGQ
R
Q
R
V
A
I
A
R
A
I
INQP
K
V
V
L
LDEPL
S
A
LD
L
K
L
R
T
E
M
Q
Y
E
L
R
E
L
Q
Q
RL
G
I
T
F
V
F
V
THDQ
E
E
ALAMS
D
W
I
F
V
MNE
G
E
I
VQSGTPVDI
Y
D
E
P
I
N
H
F
V
A
T
F
IGES--NI------LS
G
K
M
I
E
D
Y
L
V
E----FN-------G
K
R
F
E
AV--DGGMRPNE
S
--
V
Q
V
------
V
I
RPE
D
L
------
Q
I
TLPDE
G
K
L
Q
V
K
V
D
T
Q
L
FRG
V
H
Y
E
I
I
A
Y
DDLG-N
E
W
M
IH----
S
----
T
R-------------KAI-----------E--G
E
V
I
G
L
DFTPE
D
I
H
I
M
RLNE
T
E
E
E
F
D
A
R
I
E
E
Y
VDTDDHE
D
G
L
I
N
A
I
E
E
E
RNEENL
20
PsiBlast_PDB
88.73
37%
-113
- C2 -
3RLF
3
MALK_ECOLI
A:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
-------------
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
A
----------------------
104
HHSearch
88.70
37%
-101
- C2 -
3RLF
3
MALK_ECOLI
A:
[2-360]
---
A
S
V
Q
L
Q
N
V
T
K
A
W
G
--
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
------
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
MPN----
R
Q
Q
V
W
L
P
VE
S
R
D
V
Q
V
G
A
N
--
M
S
L
------
G
I
R
P
E
H
L
------
L
P
S
D
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
----
Q
N
D
--
V
V
-------------
L
V
E
-----------
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
A
----------------------
18
PsiBlast_PDB
88.68
37%
-113
- C2 -
3PUW
5
MALK_ECOLI
A:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
-------------
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
A
----------------------
17
PsiBlast_PDB
88.30
37%
-112
- C2 -
3PUV
5
MALK_ECOLI
A:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
-------------
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
A
----------------------
19
PsiBlast_PDB
88.01
37%
-109
- C2 -
3PUX
5
MALK_ECOLI
A:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
-------------
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
A
----------------------
24
PsiBlast_CBE
87.93
37%
-109
- C2 -
4KI0
4
?
A:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
-------------
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
A
----------------------
36
PsiBlast_CBE
87.79
37%
-108
- C2 -
2R6G
2
MALK_ECOLI (first)
A:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
I
QIP
S
----
I
R
-------------
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
A
----------------------
26
PsiBlast_CBE
87.79
37%
-112
- C2 -
3PUZ
2
MALK_ECOLI
B:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
NFLPVK
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
GANMSL
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
IQIP
S
----
I
R
-------------
Q
N
L
VYRQNDVVLVE
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
-----------------------
14
PsiBlast_PDB
87.63
37%
-111
- C2 -
3PUY
3
MALK_ECOLI
A:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
-------------
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
A
----------------------
31
PsiBlast_CBE
87.54
37%
-112
- C2 -
2AWN
2
MALK_ECOLI
B:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
-------------
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
A
S
A
S
-------------------
122
Fugue
87.52
38%
-108
- C2 -
1Z47
1
?
A:
[11-355]
-
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
-
P
G
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
-
G
D
V
W
I
G
G
K
R
V
T
D
------
L
P
P
Q
----
K
R
N
V
G
L
--------
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
-
G
L
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
--
N
V
------
W
T
R
A
-
V
Q
N
G
R
I
E
----
V
A
-------
G
A
A
L
P
-
V
--
D
P
A
V
S
E
G
S
E
--
V
A
V
------
V
V
R
P
K
D
V
------
E
L
Q
P
A
S
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
-
E
V
W
E
V
H
----
V
----
P
S
-------------
A
D
R
-----------
H
RW
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
-------------------------------------
25
PsiBlast_CBE
87.52
37%
-111
- C2 -
3RLF
3
MALK_ECOLI
B:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
NFLPVK
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
GANMSL
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
IQIP
S
----
I
R
-------------
Q
N
L
VYRQNDVVLVE
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
A
----------------------
107
HHSearch
87.36
39%
-107
- C2 -
1Z47
1
?
A:
[13-354]
---
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
-
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
-
G
D
V
W
I
G
G
K
R
V
T
D
------
L
P
P
Q
----
K
R
N
V
G
L
--------
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
-
G
L
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
--
N
V
------
W
T
R
A
V
Q
N
G
R
I
-
E
----
V
A
-------
G
A
A
L
P
V
---
D
P
A
V
S
E
G
S
E
--
V
A
V
------
V
V
R
P
K
D
V
------
E
L
Q
P
A
S
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
-
E
V
W
E
V
H
----
V
P
SAD
R
H
-------------
R
W
S
-----------
P
--
G
A
W
V
H
M
N
--
V
T
R
W
F
I
F
P
R
-------------------------------------
15
PsiBlast_PDB
87.26
37%
-109
- C2 -
3PUZ
2
MALK_ECOLI
A:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
-------------
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
-----------------------
23
PsiBlast_CBE
87.23
37%
-110
- C2 -
4KI0
3
?
B:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
NFLPVK
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
GANMSL
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
IQIP
S
----
I
R
-------------
Q
N
L
VYRQNDVVLVE
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
A
----------------------
29
PsiBlast_CBE
86.74
37%
-106
- C2 -
2AWO
2
MALK_ECOLI
B:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
NFLPVK
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
GANMSL
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
IQIP
S
----
I
R
-------------
Q
N
L
VYRQNDVVLVE
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
A
S
A
S
-------------------
2
PsiBlast_PDB
86.29
40%
-102
- C2 -
2D62
8
?
A:
[11-367]
---------
N
I
W
K
R
F
G
D
V
T
A
V
--
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
-
G
Q
I
Y
I
E
D
N
L
V
A
D
PEKG
V
F
V
P
P
K
----
E
R
D
V
A
M
--------
V
F
Q
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
I
A
F
-
P
L
K
L
R
K
V
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
T
E
L
L
N
R
K
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
G
S
P
P
M
N
F
------
L
D
A
T
I
T
D
D
G
F
L
D
----
F
G
E
F
K
L
K
L
L
Q
D
Q
F
E
V
L
--
E
E
E
N
M
V
G
K
E
--
V
I
F
------
G
I
R
P
E
D
V
HDASFT
H
I
D
V
P
E
E
N
T
V
K
A
T
V
D
I
------------
I
E
N
L
G
-
G
E
K
I
V
H
----
L
----
R
R
GN
I
S
F
T
A
K
F
P
KES
K
V
R
-----------
E
--
G
D
E
V
S
V
V
F
D
M
K
K
I
H
I
F
R
K
D
T
E
K
A
I
F
------------------------------
10
PsiBlast_PDB
86.07
37%
-107
- C2 -
1Q1E
-
MALK_ECOLI
A:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
-------------
Q
N
L
V
Y
R
Q
N
D
VV
L
V
E
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
------------------------
16
PsiBlast_PDB
85.91
37%
-107
- C2 -
3PV0
-
MALK_ECOLI
A:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
I
QIP
S
----
I
R
-------------
Q
N
L
V
Y
R
Q
N
DVVLVE
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
-----------------------
12
PsiBlast_PDB
85.75
37%
-108
- C2 -
2AWO
2
MALK_ECOLI
A:
[4-360]
-----
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
-
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
----
E
R
G
V
G
M
--------
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
-
G
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
--
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
----
L
P
-------
M
P
N
R
Q
Q
V
-----
W
L
P
V
E
S
RD
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
---------
L
P
S
D
------
I
A
D
V
I
L
E
G
---
E
V
Q
V
V
E
Q
L
G
-
N
E
T
Q
I
H
I
Q
I
P
S
----
I
R
-------------
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
--
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
A
S
---------------------
53
PsiBlast_CBE
63.01
37%
-106
- C2 -
4U00
3
?
A:
[3-238]
---
P
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
--
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
-
G
E
V
V
V
D
G
L
S
V
K
D
DRA---
L
R
E
I
----
R
R
E
V
G
M
--------
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
--
L
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
59.83
37%
-105
- C2 -
2OLJ
4
?
A:
[39-261]
---------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
N
L
K
A
------
K
D
T
N
L
N
K
V
R
E
E
V
G
M
--------
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
59.29
37%
-99
- C2 -
2OLK
2
?
B:
[39-261]
---------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
N
L
K
A
------
K
D
T
N
LNKV
R
E
E
V
G
M
--------
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
59.02
37%
-100
- C2 -
2OLK
1
?
C:
[39-261]
---------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
N
L
K
A
------
K
D
T
N
LNKV
R
E
E
V
G
M
--------
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
58.93
37%
-100
- C2 -
2OLK
1
?
A:
[39-261]
---------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
N
L
K
A
------
K
D
T
N
L
N
K
V
R
E
E
V
G
M
--------
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
58.64
37%
-101
- C2 -
3C4J
4
?
B:
[39-261]
---------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
N
L
K
A
------
K
D
T
N
LNKV
R
E
E
V
G
M
--------
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
58.49
37%
-98
- C2 -
2OLK
1
?
D:
[39-261]
---------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
N
L
K
A
------
K
D
T
N
LNKV
R
E
E
V
G
M
--------
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
58.49
37%
-101
- C2 -
3C41
3
?
K:
[18-240]
---------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
N
L
K
A
------
K
D
T
N
LNKV
R
E
E
V
G
M
--------
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
57.94
37%
-100
- C2 -
2Q0H
4
?
A:
[39-261]
---------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
N
L
K
A
------
K
D
T
N
L
N
K
V
R
E
E
V
G
M
--------
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
57.93
37%
-99
- C2 -
3C4J
3
?
A:
[39-261]
---------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
N
L
K
A
------
K
D
T
N
L
N
K
V
R
E
E
V
G
M
--------
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
57.45
37%
-98
- C2 -
3C41
3
?
J:
[18-240]
---------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
N
L
K
A
------
K
D
T
N
LNKV
R
E
E
V
G
M
--------
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
56.76
37%
-97
- C2 -
2Q0H
4
?
B:
[39-261]
---------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
N
L
K
A
------
K
D
T
N
L
N
K
V
R
E
E
V
G
M
--------
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
56.62
39%
-101
- C2 -
4YMU
2
?
J:
[16-238]
---------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
-
G
E
V
F
I
D
G
V
K
I
N
N
------
G
K
V
N
INKV
R
Q
K
V
G
M
--------
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
56.51
39%
-99
- C2 -
4YMV
1
?
J:
[16-238]
---------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
-
G
E
V
F
I
D
G
V
K
I
N
N
------
G
K
V
N
INKV
R
Q
K
V
G
M
--------
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
56.43
39%
-100
- C2 -
4YMU
2
?
A:
[16-238]
---------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
-
G
E
V
F
I
D
G
V
K
I
N
N
------
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
--------
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
56.01
39%
-98
- C2 -
4YMV
1
?
A:
[16-238]
---------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
-
G
E
V
F
I
D
G
V
K
I
N
N
------
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
--------
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
--
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
55.99
37%
-96
- C2 -
2OLJ
3
?
B:
[39-261]
---------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
-
G
E
I
I
I
D
G
I
N
L
K
A
------
K
D
T
N
LNKV
R
E
E
V
G
M
--------
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
--
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
48.71
35%
-91
- C2 -
2PCL
12
LOLD_AQUAE
A:
[4-224]
----
I
L
R
A
E
N
I
K
K
V
I
R
G
Y
E
--
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
-
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
--------
T
N
----
E
K
E
L
S
L
L
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
-
P
M
L
K
M
G
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
K
L
S
R
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
-
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
G
G
T
S
I
V
M
V
T
H
E
R
E
L
A
-
E
L
T
H
R
T
L
E
M
K
D
G
K
V
V
G
E
I
T
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------