@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1180: (2015-12-06 )
MTTVYLSLGSNIGDRETFLKQALFSIDHLQKTKVAQISAIYETAAWGNTNQEDFFNICCQVETDLAPFELLDYCQEIEKRLKRVRHEHWGPRTIDIDILLFGNQVINQEDLVVPHPYMTKRAFVLVPLLEIAPQLSLPNGSKLEDYLEKLNLGEVHYLKPVE
Atome Classification :
(44 SA)
.........10........20........30........40........50........60........70........80.....-.-..90........100.......110.......120.......130.......140.....-----..150.......160
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
T
V
Y
L
SLGSNIG
D
R
E
T
F
L
K
Q
A
L
F
S
I
D
H
L
Q
KT
K
V
A
Q
I
S
A
I
Y
ETAAWGNT
N
Q
E
D
F
F
N
I
C
C
Q
VETDL
A
P
F
E
L
L
D
Y
C
Q
E
I
E
K
R
L
K
R
V
R
H
-E-HWG
P
R
T
I
D
I
D
I
L
L
FGNQVINQEDLVVPHPYMT
K
R
A
F
V
L
V
P
L
L
E
IAPQLSLPN
G
S
K
L
E
D
Y
L
-----
E
KLNLG
E
V
H
Y
LKPVE
37
PsiBlast_CBE
95.59
42%
-148
- C7 -
3HD2
5
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
A
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
44
PsiBlast_CBE
94.69
42%
-147
- C7 -
1G4C
4
HPPK_ECOLI
B:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
A
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
HTRAF
D
K
L
N
K
W
---------
62
Fugue
94.68
40%
-140
- C7 -
1CBK
2
HPPK_HAEIN
A:
[1-160]
M
I
T
A
Y
I
A
L
G
S
N
L
N
T
P
V
E
Q
L
H
A
A
L
K
A
I
S
Q
L
S
N
T
H
L
V
T
T
S
S
F
Y
K
S
K
P
L
G
P
Q
D
Q
P
D
Y
V
N
A
V
A
K
I
E
T
E
L
S
P
L
K
L
L
D
E
L
Q
R
I
E
N
E
Q
G
R
V
R
L
--R
R
W
G
E
R
T
L
D
L
D
I
L
L
Y
G
N
E
I
I
Q
N
E
R
L
T
I
P
H
Y
D
M
H
N
R
E
F
V
I
V
P
L
F
E
I
A
S
D
L
V
L
P
N
S
Q
I
I
T
E
L
V
-----
K
Q
F
A
D
H
K
M
I
K
L
N
P
--
29
PsiBlast_CBE
94.17
42%
-151
- C7 -
3UDE
2
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
----
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
71
HHSearch
94.09
40%
-138
- C7 -
1CBK
2
HPPK_HAEIN
A:
[1-160]
M
I
T
A
Y
I
A
L
G
S
N
L
N
T
P
V
E
Q
L
H
A
A
L
K
A
I
S
Q
L
S
N
T
H
L
V
T
T
S
S
F
Y
K
S
K
P
L
G
P
Q
D
Q
P
D
Y
V
N
A
V
A
K
I
E
T
E
L
S
P
L
K
L
L
D
E
L
Q
R
I
E
N
E
Q
G
R
V
R
L
-
R
-
R
W
G
E
R
T
L
D
L
D
I
L
L
Y
G
N
E
I
I
Q
N
E
R
L
T
I
P
H
Y
D
M
H
N
R
E
F
V
I
V
P
L
F
E
I
A
S
D
L
V
L
P
N
S
Q
I
I
T
E
L
V
-----
K
Q
F
A
D
H
K
M
I
K
L
N
P
--
19
PsiBlast_PDB
93.90
42%
-151
- C7 -
1RAO
2
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
41
PsiBlast_CBE
93.84
42%
-143
- C7 -
1KBR
1
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
A
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
W
---------
16
PsiBlast_PDB
93.69
42%
-148
- C7 -
1EQM
3
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
39
PsiBlast_CBE
93.57
42%
-152
- C7 -
3HD1
5
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
A
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
28
PsiBlast_CBE
93.56
42%
-150
- C7 -
3UDV
2
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
----
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
30
PsiBlast_CBE
93.53
42%
-152
- C7 -
3UD5
3
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
56
PsiBlast_CBE
93.29
42%
-141
- C7 -
1TMJ
3
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
A
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
W
---------
26
PsiBlast_CBE
93.11
43%
-142
- C7 -
4M5N
4
HPPK_ECOLI
B:
[4-160]
M
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
HTRAF
D
K
L
N
K
W
---------
13
PsiBlast_PDB
92.92
43%
-144
- C7 -
4M5N
4
HPPK_ECOLI
A:
[4-160]
M
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
8
PsiBlast_PDB
92.86
43%
-138
- C7 -
4M5I
6
HPPK_ECOLI
A:
[4-160]
M
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
W
---------
55
PsiBlast_CBE
92.65
42%
-140
- C7 -
1TMM
11
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
A
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
RA
F
D
K
L
N
K
W
---------
9
PsiBlast_PDB
92.61
43%
-144
- C7 -
4M5J
6
HPPK_ECOLI
A:
[4-160]
M
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
--
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
RAF
D
K
L
N
K
W
---------
42
PsiBlast_CBE
92.59
42%
-144
- C7 -
1IM6
1
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
A
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
W
---------
36
PsiBlast_CBE
92.55
42%
-143
- C7 -
3KUE
2
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
A
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
W
---------
10
PsiBlast_PDB
92.52
43%
-141
- C7 -
4M5K
6
HPPK_ECOLI
A:
[4-160]
M
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
W
---------
6
PsiBlast_PDB
92.41
43%
-139
- C7 -
4M5G
8
HPPK_ECOLI
A:
[4-160]
M
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
W
---------
12
PsiBlast_PDB
92.31
43%
-144
- C7 -
4M5M
7
HPPK_ECOLI
A:
[4-160]
M
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
W
---------
11
PsiBlast_PDB
92.28
43%
-138
- C7 -
4M5L
6
HPPK_ECOLI
A:
[4-160]
M
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
W
---------
72
HHSearch
92.19
38%
-140
- C7 -
2QX0
5
?
A:
[1-158]
M
I
R
V
Y
I
A
L
G
S
N
L
A
M
P
L
Q
Q
V
S
A
A
R
E
A
L
A
H
L
P
R
S
R
L
V
A
C
S
P
L
Y
R
T
K
P
L
G
P
Q
D
Q
P
D
F
L
N
A
V
V
A
L
D
T
S
L
P
P
E
Q
L
L
D
H
T
Q
A
I
E
R
N
Q
G
R
V
R
K
E
Q
-
R
W
G
P
R
T
L
D
L
D
I
M
L
Y
G
D
Q
V
I
K
T
D
R
L
T
I
P
H
Y
G
L
K
A
R
E
F
M
L
Y
P
L
A
D
I
A
P
D
L
I
F
P
D
G
E
S
L
S
E
C
L
-----
K
R
V
D
K
N
G
L
V
L
W
----
27
PsiBlast_CBE
92.08
42%
-143
- C7 -
4F7V
1
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
53
PsiBlast_CBE
92.03
42%
-139
- C7 -
3KUH
6
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
A
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
14
PsiBlast_PDB
92.01
42%
-137
- C7 -
1DY3
4
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
59
PsiBlast_CBE
91.81
40%
-163
- C7 -
1RU1
5
HPPK_ECOLI
A:
[1-150]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
------
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
----------
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
40
PsiBlast_CBE
91.68
42%
-148
- C7 -
3HCX
2
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
A
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
54
PsiBlast_CBE
91.57
42%
-139
- C7 -
1TMM
7
HPPK_ECOLI
B:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
A
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
HTRAF
D
K
L
N
K
W
---------
18
PsiBlast_PDB
91.53
42%
-141
- C7 -
1Q0N
9
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
38
PsiBlast_CBE
91.34
42%
-152
- C7 -
3HSJ
4
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
A
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
58
PsiBlast_CBE
91.15
40%
-149
- C7 -
1RU1
4
HPPK_ECOLI
B:
[1-150]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
-------
G
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
7
PsiBlast_PDB
91.14
43%
-137
- C7 -
4M5H
9
HPPK_ECOLI
A:
[4-160]
M
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
W
---------
43
PsiBlast_CBE
91.13
42%
-138
- C7 -
1HQ2
9
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
A
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
49
PsiBlast_CBE
90.98
42%
-142
- C7 -
3ILJ
4
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
A
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
46
PsiBlast_CBE
90.89
42%
-138
- C7 -
1F9H
5
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
A
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
47
PsiBlast_CBE
90.65
42%
-139
- C7 -
3ILO
5
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
A
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
20
PsiBlast_PDB
90.60
42%
-136
- C7 -
1RB0
1
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
15
PsiBlast_PDB
90.54
42%
-142
- C7 -
1EX8
3
HPPK_ECOLI
A:
[1-156]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
V
R
K
A
E
-
R
W
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
57
PsiBlast_CBE
90.46
40%
-158
- C7 -
1RU2
5
HPPK_ECOLI
A:
[1-150]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
------
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
-------
G
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
60
PsiBlast_CBE
88.62
40%
-152
- C7 -
1RTZ
8
HPPK_ECOLI
A:
[1-150]
-
T
V
A
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
Q
Q
G
R
-------
G
G
P
R
T
L
D
L
D
I
M
L
F
G
N
E
V
I
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
P
E
L
V
F
P
D
G
E
M
L
R
Q
I
L
H
T
R
AF
D
K
L
N
K
W
---------
5
PsiBlast_PDB
86.19
47%
-140
- C7 -
4CWB
5
?
A:
[4-146]
M
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
D
A
I
K
I
L
N
E
Y
D
G
I
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
K
-
E
-
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
V
E
P
R
-
S
K
L
K
V
K
D
-----
L
V
F
V
D
D
S
V
K
R
Y
K
---
4
PsiBlast_PDB
85.45
47%
-139
- C7 -
4CRJ
5
?
A:
[4-146]
M
I
Q
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
D
A
I
K
I
L
N
E
Y
D
G
I
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
C
L
H
R
I
R
K
-
E
-
R
W
G
P
R
T
L
D
V
D
I
L
L
Y
G
E
E
M
I
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
A
N
V
V
E
P
R
-
S
K
L
K
V
K
D
-----
L
V
F
V
D
D
S
V
K
R
Y
K
---