@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1253: (2015-12-06 )
MTLLEKINETRDFLQAKGVTAPEFGLILGSGLGELAEEIENPIVVDYADIPNWGQSTVVGHAGKLVYGDLSGRKVLALQGRFHFYEGNTMEIVTFPVRIMRALACHSVLVTNAAGGIGYGPGTLMLIKDHINVIGTNPLIGENLEEFGPRFPDMSDAYTATYRQKAHQIAEKQNIKLEEGVYLGVSGPTYETPAEIRAFQTMGAQAVGMSTVPEVIVAAHSGLKVLGISAITNFAAGFQSELNHEEVVEVTQRIKEDFKGLVKSLVAEL
Atome Classification :
(70 SA)
.........10.......-.-20........30........40-........50........60........70........80........90....---....100.......110.....--.--.120.........130---.---..---.---...140.......150.......160....----.----..170--...--.--.--..180.......190.......200.......210.......220.......230.---...-.---..---240-..--.......250.......260.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
L
L
E
K
I
N
E
T
R
D
F
L
Q
AKG-V-TAP
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
IEN-
P
I
V
V
D
YADIPNWGQSTVVGHAG
K
L
V
Y
GDLSG
R
K
V
L
A
LQ
G
R
F
H
F
YEG
N
T
M
E
I
V
T
F
---
P
V
R
I
M
R
A
L
A
C
H
S
V
L
VTNAAGGI--G--YG--P
G
T
L
M
L
I
KDH
I
N
---
V
---IG---T---NPLIGE
N
L
E
E
FGPRFPDM
S
D
A
Y
T
A
T
Y
R
Q
K
A
----
H
----
Q
I
A
E
K--QN
I
--
K
--L--EE
G
V
Y
L
GVSGPTYET
P
A
E
I
R
A
F
Q
T
MGAQAVG
M
S
T
V
P
E
V
I
V
A
AHSG
L
K
V
L
G
I
S
A
I
T
N
---
F
A
A
-
G
---
F
Q
---S---EL--
N
H
E
E
V
V
E
V
T
Q
R
I
K
E
D
F
K
G
L
V
K
S
L
V
AEL
101
HHSearch
97.42
79%
-129
- C3 -
3LA8
1
?
A:
[36-303]
-
S
L
L
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
-
V
-
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
N
-
A
L
V
L
N
Y
A
D
I
P
N
W
G
---------
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
-
R
F
H
Y
Y
E
G
-
S
M
E
L
V
T
F
---
P
I
R
I
M
K
A
L
G
C
Q
G
L
I
V
T
N
A
A
G
G
I
--
G
--
F
G
--
P
G
T
L
M
A
I
S
D
H
I
N
---
L
---
T
G
---
A
---
N
P
L
M
G
-
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
----
H
----
Q
V
A
D
K
--
I
G
I
--
K
--
L
--
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
---
Y
A
A
-
G
---
F
-----------------
V
A
V
T
Q
Q
I
K
E
D
F
K
G
L
V
K
A
I
L
V
E
L
2
PsiBlast_PDB
97.18
78%
-116
- C3 -
3LBA
2
?
A:
[35-303]
M
S
L
L
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
-
V
-
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
N
-
A
L
V
L
N
Y
A
D
I
P
N
W
G
R
S
------
G
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
G
R
F
H
Y
Y
E
G
N
S
M
E
L
V
T
F
---
P
I
R
I
M
K
A
L
G
C
Q
G
L
I
V
T
N
A
A
G
G
I
--
G
--
F
G
--
P
G
T
L
M
A
I
S
D
H
I
N
---
L
---
T
G
---
A
---
N
P
L
M
G
E
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
----
H
----
Q
V
A
D
K
--
I
G
I
--
K
--
L
--
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
---
Y
A
A
-
G
---
F
Q
---
S
---
E
L
--
N
---
V
V
A
V
T
Q
Q
I
K
E
D
F
K
G
L
V
K
A
I
L
V
E
L
1
PsiBlast_PDB
97.14
78%
-129
- C3 -
3LA8
1
?
A:
[36-303]
-
S
L
L
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
-
V
-
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
N
-
A
L
V
L
N
Y
A
D
I
P
N
W
G
---------
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
-
R
F
H
Y
Y
E
G
-
S
M
E
L
V
T
F
---
P
I
R
I
M
K
A
L
G
C
Q
G
L
I
V
T
N
A
A
G
G
I
--
G
--
F
G
--
P
G
T
L
M
A
I
S
D
H
I
N
---
L
---
T
G
---
A
---
N
P
L
M
G
-
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
----
H
----
Q
V
A
D
K
--
I
G
I
--
K
--
L
--
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
---
Y
A
A
-
G
---
F
-----------------
V
A
V
T
Q
Q
I
K
E
D
F
K
G
L
V
K
A
I
L
V
E
L
8
PsiBlast_PDB
81.60
46%
-100
- C3 -
4PNP
1
PNPH_BOVIN
A:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
T
-
E
---
S
Q
---
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
15
PsiBlast_PDB
81.09
46%
-99
- C3 -
1B8O
2
PNPH_BOVIN
A:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
-
E
---
S
Q
---
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
102
HHSearch
81.08
47%
-106
* C3 *
3FUC
3
PNPH_BOVIN
A:
[4-282]
G
Y
T
Y
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
--
N
PN
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
---
P
G
---
F
S
GE
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
----
S
T
W
K
Q
--
M
G
E
Q
R
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---
K
V
I
-
M
---
D
Y
ESQ
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
33
PsiBlast_CBE
80.90
46%
-104
- C3 -
2AI3
4
PNPH_BOVIN
A:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
I
M
D
Y
--------------
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
107
HHSearch
80.73
42%
-102
- C3 -
3ODG
2
?
A:
[13-284]
-
D
F
N
E
L
P
F
Q
A
V
K
Y
I
Q
K
I
K
P
G
-
F
K
P
Q
I
A
F
I
L
G
S
G
L
G
D
L
V
D
Q
I
T
N
-
D
T
T
I
S
Y
A
D
I
P
G
F
P
V
S
S
V
H
G
H
A
G
E
L
V
L
G
D
L
C
G
V
P
V
M
C
M
K
G
R
G
H
F
Y
E
G
K
G
M
S
I
M
T
N
---
P
V
R
T
F
K
L
M
G
C
E
F
L
F
C
T
N
A
A
G
S
L
--
R
PE
V
L
--
P
G
S
V
V
M
L
K
D
H
I
N
---
T
---
M
P
---
G
---
T
P
L
V
G
P
N
D
D
R
F
G
P
R
F
F
S
L
A
N
A
Y
D
K
D
L
R
A
D
M
----
A
----
K
I
A
Q
Q
--
L
D
I
--
P
--
L
--
T
E
G
V
F
V
S
Y
P
G
P
C
F
E
T
P
A
E
I
R
M
M
Q
I
I
G
G
D
V
V
G
M
S
V
V
P
E
V
L
S
A
A
H
C
G
L
K
V
I
A
L
T
A
I
T
N
---
L
A
E
-
G
---
L
S
D--
V
---
V
L
--
S
H
E
Q
T
L
K
F
A
K
V
A
S
V
N
F
T
K
L
I
E
A
F
L
K
S
K
16
PsiBlast_PDB
80.72
46%
-107
- C3 -
3FUC
3
PNPH_BOVIN
A:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
-
E
---
S
Q
---
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
50
PsiBlast_CBE
80.71
46%
-103
- C3 -
3K8O
7
PNPH_HUMAN
Y:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
LSTW
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
20
PsiBlast_PDB
80.62
46%
-106
- C3 -
2AI1
4
PNPH_BOVIN
A:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
-
E
---
S
Q
---
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
32
PsiBlast_CBE
80.45
46%
-106
- C3 -
3FUC
2
PNPH_BOVIN
B:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
STWK
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
-
E
---
S
Q
---
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
14
PsiBlast_PDB
80.42
46%
-100
- C3 -
1B8N
3
PNPH_BOVIN
A:
[8-279]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
-
E
---
S
Q
---
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
---
11
PsiBlast_PDB
80.41
46%
-98
- C3 -
1A9S
2
PNPH_BOVIN
A:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
T
-
E
---
S
Q
---
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
31
PsiBlast_CBE
80.30
46%
-106
- C3 -
3FUC
5
PNPH_BOVIN
C:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
STWK
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
-
E
---
S
Q
---
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
5
PsiBlast_PDB
80.23
46%
-99
- C3 -
1A9T
2
PNPH_BOVIN
A:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
T
-
E
---
S
Q
---
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
6
PsiBlast_PDB
80.17
46%
-100
- C3 -
1FXU
4
PNPH_BOVIN
A:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
T
----------
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
51
PsiBlast_CBE
80.12
46%
-104
- C3 -
3K8O
6
PNPH_HUMAN
U:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
LSTW
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
18
PsiBlast_PDB
80.12
46%
-106
- C3 -
2QPL
2
PNPH_BOVIN
A:
[6-280]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
----
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
I
M
D
Y
------------------------
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
76
PsiBlast_CBE
80.11
45%
-104
- C3 -
4EB8
4
PNPH_HUMAN
B:
[43-317]
----
E
D
Y
K
N
T
A
E
Y
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
W
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
4
PsiBlast_PDB
79.94
46%
-104
- C3 -
1A9R
2
PNPH_BOVIN
A:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
T
-
E
---
S
Q
---
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
77
PsiBlast_CBE
79.86
45%
-100
- C3 -
4EB8
3
PNPH_HUMAN
A:
[43-317]
----
E
D
Y
K
N
T
A
E
Y
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
W
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
34
PsiBlast_CBE
79.79
46%
-101
- C3 -
2AI2
4
PNPH_BOVIN
A:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
-
E
---
S
Q
---
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
75
PsiBlast_CBE
79.73
45%
-101
- C3 -
4EB8
3
PNPH_HUMAN
C:
[43-317]
----
E
D
Y
K
N
T
A
E
Y
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
LSTY
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
W
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
3
PsiBlast_PDB
79.73
46%
-100
- C3 -
1A9Q
2
PNPH_BOVIN
A:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
I
M
D
T
-
E
---
S
Q
---
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
19
PsiBlast_PDB
79.59
46%
-108
- C3 -
1V48
3
PNPH_BOVIN
A:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
Y
-
E
---------------------------
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
17
PsiBlast_PDB
79.34
46%
-101
- C3 -
1VFN
3
PNPH_BOVIN
A:
[5-279]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
-------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
----
S
T
W
K
Q
M
G
E
Q
R
--
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
------
S
Q
---
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
58
PsiBlast_CBE
79.23
46%
-101
- C3 -
3BGS
4
PNPH_HUMAN
A:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
49
PsiBlast_CBE
79.21
46%
-106
- C3 -
3K8Q
3
PNPH_HUMAN
A:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
80
PsiBlast_CBE
78.99
45%
-104
- C3 -
2A0Y
3
PNPH_HUMAN
A:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
D
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
10
PsiBlast_PDB
78.95
46%
-95
- C3 -
1A9P
2
PNPH_BOVIN
A:
[8-282]
----
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
-
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
-
A
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
---
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
NP
N
--
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
E
---
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
----
H
S
T
W
K
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
KVI
M
D
T
-
E
---
S
Q
---
G
---
K
A
--
N
H
E
E
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
81
PsiBlast_CBE
78.68
45%
-104
- C3 -
2ON6
1
PNPH_HUMAN
A:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
----
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
F
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
65
PsiBlast_CBE
78.40
46%
-103
- C3 -
1RR6
4
PNPH_HUMAN
A:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
64
PsiBlast_CBE
78.32
46%
-102
- C3 -
1RSZ
4
PNPH_HUMAN
A:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
82
PsiBlast_CBE
78.21
45%
-101
- C3 -
2A0X
3
PNPH_HUMAN
A:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
F
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
79
PsiBlast_CBE
78.21
45%
-103
- C3 -
2OC4
2
PNPH_HUMAN
A:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
D
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
63
PsiBlast_CBE
77.91
46%
-102
- C3 -
1RT9
4
PNPH_HUMAN
A:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
59
PsiBlast_CBE
77.57
46%
-100
- C3 -
2Q7O
2
PNPH_HUMAN
E:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
LSTW
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
105
HHSearch
77.51
41%
-93
- C3 -
2P4S
4
?
A:
[90-367]
-
Y
T
Y
D
T
L
Q
E
I
A
T
Y
L
L
E
R
T
-
E
-
L
R
P
K
V
G
I
I
C
G
S
G
L
G
T
L
A
E
Q
L
T
D
-
V
D
S
F
D
Y
E
T
I
P
H
F
P
V
S
T
V
A
G
H
V
G
R
L
V
F
G
Y
L
A
G
V
P
V
M
C
M
Q
G
R
F
H
H
Y
E
G
Y
P
L
A
K
C
A
M
---
P
V
R
V
M
H
L
I
G
C
T
H
L
I
A
T
N
A
A
G
G
A
--
N
PK
Y
R
--
V
G
D
I
M
L
I
K
D
H
I
N
---
L
---
M
G
---
F
A
GN
N
P
L
Q
G
P
N
D
E
R
F
G
P
R
F
F
G
M
A
N
T
Y
D
P
K
L
N
Q
Q
A
----
K
----
V
I
A
R
Q
--
I
G
I
EN
E
--
L
--
R
E
G
V
Y
T
C
L
G
G
P
N
F
E
T
V
A
E
V
K
M
L
S
M
L
G
V
D
A
I
G
M
S
T
V
H
E
I
I
T
A
R
H
C
G
M
T
C
F
A
F
S
L
I
T
N
---
M
C
T
-
M
---
S
Y
---
E
E
E
E
E
H
--
C
H
D
S
I
V
G
V
G
K
N
R
E
K
T
L
G
E
F
V
S
R
I
V
K
H
I
37
PsiBlast_CBE
77.29
46%
-99
- C3 -
1V3Q
4
PNPH_HUMAN
E:
[7-281]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
LSTW
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
90
PsiBlast_CBE
77.28
45%
-99
- C3 -
2A0W
3
PNPH_HUMAN
A:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
G
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
83
PsiBlast_CBE
77.25
45%
-104
- C3 -
3GGS
13
PNPH_HUMAN
C:
[30-304]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
----
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
87
PsiBlast_CBE
77.14
45%
-105
- C3 -
3GB9
9
PNPH_HUMAN
B:
[30-304]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
-----
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K--
V
I
M
-
D
---
Y
E
------------------
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
86
PsiBlast_CBE
77.05
45%
-104
- C3 -
3GB9
14
PNPH_HUMAN
C:
[30-304]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
----
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K--
V
I
M
-
D
---
Y
E
---
S
-----------
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
40
PsiBlast_CBE
77.04
46%
-97
- C3 -
1RCT
4
PNPH_HUMAN
E:
[7-281]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
LSTW
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
36
PsiBlast_CBE
76.99
46%
-95
- C3 -
1V41
5
PNPH_HUMAN
E:
[7-281]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
LSTW
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
89
PsiBlast_CBE
76.93
45%
-100
- C3 -
2OC9
2
PNPH_HUMAN
A:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
------
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
G
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
66
PsiBlast_CBE
76.86
46%
-95
- C3 -
1PF7
4
PNPH_HUMAN
E:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
LSTW
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
99
PsiBlast_CBE
76.79
40%
-104
- C3 -
3FNQ
4
?
A:
[9-284]
---
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
-
S
-
I
V
P
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
-
K
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
---
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
---
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
--
N
--
R
S
LK
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
---
P
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
----
V
----
Q
V
A
E
E
--
N
G
F
--
G
NL
V
--
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
---
I
S
V
L
D
---
V
E
---
S
---
D
L
K
P
N
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
38
PsiBlast_CBE
76.78
46%
-100
- C3 -
1V2H
5
PNPH_HUMAN
E:
[7-281]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
LSTW
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
35
PsiBlast_CBE
76.62
46%
-99
- C3 -
1V45
4
PNPH_HUMAN
E:
[7-281]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
LSTW
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
84
PsiBlast_CBE
76.42
45%
-104
- C3 -
3GGS
16
PNPH_HUMAN
B:
[30-304]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
39
PsiBlast_CBE
76.40
46%
-96
- C3 -
1RFG
4
PNPH_HUMAN
E:
[7-281]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
LSTW
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
93
PsiBlast_CBE
76.39
40%
-100
- C3 -
3KHS
3
?
B:
[1-279]
M
T
D
Y
D
L
A
K
E
T
A
A
W
L
N
K
Q
L
-
Q
-
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
T
-
S
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
-----
A
G
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
---
P
M
R
V
F
K
A
L
G
V
K
I
V
V
L
T
N
A
A
G
G
L
NP
S
--
Y
R
--
P
G
D
F
M
V
V
R
D
H
I
N
L
P
G
L
---
A
G
---
A
---
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
----
I
----
S
A
A
R
E
--
L
G
M
--
S
--
Y
A
T
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
---
V
I
A
-
S
NCE----------------
E
V
L
R
A
G
E
E
A
S
A
R
M
T
A
L
V
K
L
V
I
E
K
I
85
PsiBlast_CBE
76.32
45%
-102
- C3 -
3GGS
14
PNPH_HUMAN
A:
[30-304]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
92
PsiBlast_CBE
76.17
40%
-100
- C3 -
3KHS
3
?
C:
[1-279]
M
T
D
Y
D
L
A
K
E
T
A
A
W
L
N
K
Q
L
-
Q
-
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
T
-
S
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
S
----
A
G
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
---
P
M
R
V
F
K
A
L
G
V
K
I
V
V
L
T
N
A
A
G
G
L
NP
S
--
Y
R
--
P
G
D
F
M
V
V
R
D
H
I
N
L
P
G
L
---
A
G
---
A
---
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
----
I
----
S
A
A
R
E
--
L
G
M
--
S
--
Y
A
T
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
---
V
I
A
-
S
NCE
T
-------------------
A
G
E
E
A
S
A
R
M
T
A
L
V
K
L
V
I
E
K
I
97
PsiBlast_CBE
76.03
40%
-101
- C3 -
3FNQ
4
?
C:
[9-284]
---
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
-
S
-
I
V
P
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
-
K
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
V
V
G
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
---
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
--
N
--
R
S
LK
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
---
P
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
----
V
----
Q
V
A
E
E
--
N
G
F
--
G
NL
V
--
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
---
I
S
V
L
D
---
V
E
---
S
---
D
L
K
P
N
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
41
PsiBlast_CBE
75.89
46%
-97
- C3 -
1PWY
4
PNPH_HUMAN
E:
[7-281]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
LSTW
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
56
PsiBlast_CBE
75.79
46%
-96
- C3 -
3INY
4
PNPH_HUMAN
A:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
94
PsiBlast_CBE
75.58
40%
-101
- C3 -
3IEX
4
?
C:
[9-284]
---
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
-
S
-
I
V
P
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
-
K
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
V
V
G
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
---
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
--
N
--
R
S
LK
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
---
P
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
----
V
----
Q
V
A
E
E
--
N
G
F
--
G
NL
V
--
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
---
I
S
V
L
D
---
V
E
---
S
---
D
L
K
P
N
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
60
PsiBlast_CBE
75.48
46%
-97
- C3 -
1YRY
4
PNPH_HUMAN
E:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
PGF
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
LSTW
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
91
PsiBlast_CBE
75.25
40%
-99
- C3 -
3KHS
2
?
D:
[1-279]
M
T
D
Y
D
L
A
K
E
T
A
A
W
L
N
K
Q
L
-
Q
-
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
T
-
S
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
-------
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
---
P
M
R
V
F
K
A
L
G
V
K
I
V
V
L
T
N
A
A
G
G
L
NP
S
--
Y
R
--
P
G
D
F
M
V
V
R
D
H
I
N
LPG
L
---
A
G
---
A
---
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
----
I
----
S
A
A
R
E
--
L
G
M
--
S
--
Y
AT
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
---
V
I
A
-
S
NCE--------------------
A
G
E
E
A
S
A
R
M
T
A
L
V
K
L
V
I
E
K
I
57
PsiBlast_CBE
75.25
46%
-93
- C3 -
3D1V
4
PNPH_HUMAN
A:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
96
PsiBlast_CBE
75.21
40%
-102
- C3 -
3IEX
5
?
A:
[9-284]
---
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
-
S
-
I
V
P
E
I
G
I
I
C
G
S
G
L
G
----
G
V
K
D
-
K
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
----
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
---
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
--
N
--
R
S
LK
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
---
P
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
----
V
----
Q
V
A
E
E
--
N
G
F
--
G
NL
V
--
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
---
I
S
V
L
D
---
V
E
---
S
---
D
L
K
P
N
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
61
PsiBlast_CBE
75.18
46%
-98
- C3 -
1ULB
3
PNPH_HUMAN
A:
[8-282]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K--
V
I
M
-
D
---
Y
E
---
S
L
E
-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
100
PsiBlast_CBE
75.13
40%
-102
- C3 -
3FB1
3
?
C:
[9-284]
---
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
-
S
-
I
V
P
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
-
K
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
V
V
G
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
---
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
--
N
--
R
S
LK
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
---
P
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
----
V
----
Q
V
A
E
E
--
N
G
F
--
G
NL
V
--
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
---
I
S
V
L
D
---
V
E
---
S
---
D
L
K
P
N
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
106
HHSearch
74.92
41%
-101
- C3 -
1TCV
3
?
A:
[6-284]
T
A
N
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
-
S
-
I
V
P
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
-
K
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
---
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
---
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
--
N
RS
L
K
--
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
---
P
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
----
V
----
Q
V
A
E
E
--
N
G
F
GN
L
--
V
--
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
---
I
S
V
-
L
---
D
V
ESD----------------
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
98
PsiBlast_CBE
74.78
40%
-103
- C3 -
3FNQ
3
?
B:
[9-284]
---
I
E
N
V
K
K
V
A
H
H
I
Q
K
L
T
-
S
-
I
V
P
E
I
G
I
I
C
G
S
----
L
A
D
G
V
K
D
-
K
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
------
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
---
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
--
N
--
R
S
LK
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
---
P
G
L
G
L
N
---
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
----
V
----
Q
V
A
E
E
--
N
G
F
--
G
NL
V
--
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
---
I
S
V
L
D
---
V
E
---
S
---
D
L
---
H
E
E
V
L
A
T
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
88
PsiBlast_CBE
74.57
45%
-99
- C3 -
3GB9
10
PNPH_HUMAN
A:
[30-304]
----
E
D
Y
K
N
T
A
E
W
L
L
S
H
T
-
K
-
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
-
A
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
---
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
--
N
PK
F
E
--
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
G
F
S
G
---
Q
---
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
----
Q
M
G
E
Q
--
R
----
E
--
L
--
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K--
V
I
M
-
D
---
Y
E
---
S
LE-
K
A
--
N
H
E
E
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
S
I
108
HHSearch
69.51
38%
-100
- C3 -
1G2O
3
PUNA_MYCTU
A:
[10-268]
----
E
L
A
R
R
A
A
Q
V
I
A
D
R
T
-
G
I
G
E
H
D
V
A
V
V
L
G
S
G
W
L
P
A
V
A
A
L
G
S
P
T
T
V
L
P
Q
A
E
L
P
G
F
V
P
P
T
A
A
G
H
A
G
E
L
L
S
V
P
I
G
A
H
R
V
L
V
L
A
G
R
I
H
A
Y
E
G
---
H
D
L
R
Y
V
V
H
P
V
R
A
A
R
A
A
G
A
Q
I
M
V
L
T
N
A
A
G
G
L
--
R
AD
L
Q
--
V
G
Q
P
V
L
I
S
D
H
L
N
---
L
---
T
A
---
R
---
S
P
L
-------
V
G
G
E
F
V
D
L
T
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A
Y
S
P
R
L
R
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L
A
----
R
----
Q
S
D
------
P
--
Q
--
L
--
A
E
G
V
Y
A
G
L
P
G
P
H
Y
E
T
P
A
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I
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H
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A
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A
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N
---
L
A
A
-
G
---
I
T
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---
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L
--
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A
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