@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1333: (2015-12-07 )
MVLTEQKRKYMEKLSDENGIISALAFDQRGALKRLMAQYQEAEPTVEQMEDLKVLVAEELTPYASSMLLDPEYGLPATKALDKNAGLLLAYEKTGYDTSSTKRLPDCLDVWSAKRIKEQGSDAVKFLLYYDVDSSDELNQQKQAYIERVGSECVAEDIPFFLEILAYDEKIADAGSAEYAKVKPRKVIEAMKVFSDSRFNIDVLKVEVPVNVKYVEGFGDGEVIHTRGEAAAFFKQQDEATNLPYIYLSAGVAAKLFQETLIFAHESGANFNGVLCGRATWAGSVKEYIEQGEEAARQWLRTTGYQNIEELNQVLKQTATSWKERV
Atome Classification :
(20 SA)
.........10......-..20........30........40.-......-.50-----........60........70.......---.80..--.......90...-.-....100...---....-110.......120.......130.......140.......150.......160.......170.......180..-.....190.......200.....--..210........220.......230.......-240.......250.--.......260......-.270.......280.......290.......300.......310.......320....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVL
T
E
Q
K
R
K
Y
M
E
K
LSDE-N
G
I
I
S
A
L
AFDQ
R
G
A
L
K
R
L
M
A
Q
Y
QEA-E
P
T
V
E
Q
-
M
E
D
-----
L
K
V
L
V
A
E
EL
T
P
Y
A
S
S
M
LLDPEYGLPA
T
---
K
A-LD--KNA
G
L
L
L
A
Y
EKT-G-YDTSSTKRL
P
---
D
C
L
D
-
V
W
S
A
K
R
I
K
EQGSD
A
V
K
F
L
L
Y
Y
DVDSS
D
E
L
N
Q
Q
K
Q
A
Y
I
E
R
V
G
S
E
C
V
A
E
D
I
P
F
F
L
E
I
L
A
Y
D
E
KIADAGSAEYAKV
K
P
-
R
K
V
I
E
A
M
K
V
FSDSRF
N
I
D
V
L
K
V
E--V
P
V
-
N
V
K
Y
V
E
GFGDG
E
V
I
HTRG
E
A
A
A
F
F
KQQDE-ATNL
P
Y
I
Y
LSA-
G
V
--
A
A
K
L
F
Q
E
T
L
I
F
A
HESG-ANF
N
G
V
L
CGRATW
A
G
S
V
K
E
Y
I
E
Q
G
E
E
A
A
R
Q
W
L
R
TTGYQ
N
I
E
E
L
N
Q
V
L
K
Q
T
A
T
S
W
KERV
3
PsiBlast_PDB
97.54
72%
-86
- C5 -
3KAO
9
LACD_STAAM
A:
[7-328]
---
S
N
Q
K
I
A
S
I
E
Q
L
S
N
N
-
E
G
I
I
S
A
L
A
F
D
Q
R
G
A
L
K
R
M
M
A
K
H
Q
T
E
-
E
P
T
V
A
Q
-
I
E
Q
-----
L
K
V
L
V
A
E
E
L
T
Q
Y
A
S
S
I
L
L
D
P
E
Y
G
L
P
A
S
---
D
A
-
R
N
--
K
D
C
G
L
L
L
A
Y
E
K
T
-
G
-
Y
D
V
N
A
K
G
R
L
P
---
D
C
L
V
-
E
W
S
A
K
R
L
K
E
Q
G
A
N
A
V
K
F
L
L
Y
Y
D
V
D
D
A
E
E
I
N
I
Q
K
K
A
Y
I
E
R
I
G
S
E
C
V
A
E
D
I
P
F
F
L
E
V
L
T
Y
D
D
N
I
P
D
N
G
S
V
E
F
A
K
V
K
P
-
R
K
V
N
E
A
M
K
L
F
S
E
P
R
F
N
V
D
V
L
K
V
E
--
V
P
V
-
N
M
K
Y
V
E
G
F
A
E
G
E
V
V
Y
T
K
E
E
A
A
Q
H
F
K
D
Q
D
A
-
A
T
H
L
P
Y
I
Y
L
S
A
-
G
V
--
S
A
E
L
F
Q
E
T
L
K
F
A
H
E
A
G
-
A
K
F
N
G
V
L
C
G
R
A
T
W
S
G
A
V
Q
V
Y
I
E
Q
G
E
D
A
A
R
E
W
L
R
T
T
G
F
K
N
I
D
D
L
N
K
V
L
K
D
T
A
T
S
W
K
Q
R
K
6
PsiBlast_PDB
97.34
71%
-87
- C5 -
3JRK
2
LACD2_STRP1
A:
[1-321]
---
T
E
N
K
R
K
S
M
E
K
L
S
-
V
-
D
G
V
I
S
A
L
A
F
D
Q
R
G
A
L
K
R
M
M
A
Q
H
Q
T
K
-
E
P
T
V
E
Q
-
I
E
E
-----
L
K
S
L
V
S
E
E
L
T
P
F
A
S
S
I
L
L
D
P
E
Y
G
L
P
A
S
---
R
V
-
R
S
--
E
E
A
G
L
L
L
A
Y
E
K
T
-
G
-
Y
D
A
T
T
T
S
R
L
P
---
D
C
L
D
-
V
W
S
A
K
R
I
K
E
A
G
A
E
A
V
K
F
L
L
Y
Y
D
I
D
G
D
Q
D
V
N
E
Q
K
K
A
Y
I
E
R
I
G
S
E
C
R
A
E
D
I
P
F
Y
L
E
I
L
T
Y
D
E
K
I
A
D
N
A
S
P
E
F
A
K
V
K
A
-
H
K
V
N
E
A
M
K
V
F
S
K
E
R
F
G
V
D
V
L
K
V
E
--
V
P
V
-
N
M
K
F
V
E
G
F
A
D
G
E
V
L
F
T
K
E
E
A
A
Q
A
F
R
D
Q
E
A
-
S
T
D
L
P
Y
I
Y
L
S
A
-
G
V
--
S
A
K
L
F
Q
D
T
L
V
F
A
A
E
S
G
-
A
K
F
N
G
V
L
C
G
R
A
T
W
A
G
S
V
K
V
Y
I
E
E
G
P
Q
A
A
R
E
W
L
R
T
E
G
F
K
N
I
D
E
L
N
K
V
L
D
K
T
A
S
P
W
T
E
K
M
2
PsiBlast_PDB
97.22
71%
-85
- C5 -
3MHG
2
LACD2_STRP1
A:
[3-325]
-
T
L
T
E
N
K
R
K
S
M
E
K
L
S
-
V
-
D
G
V
I
S
A
L
A
F
D
Q
R
G
A
L
K
R
M
M
A
Q
H
Q
T
K
-
E
P
T
V
E
Q
-
I
E
E
-----
L
K
S
L
V
S
E
E
L
T
P
F
A
S
S
I
L
L
D
P
E
Y
G
L
P
A
S
---
R
V
-
R
S
--
E
E
A
G
L
L
L
A
Y
E
K
T
-
G
-
Y
D
A
T
T
T
S
R
L
P
---
D
C
L
D
-
V
W
S
A
K
R
I
K
E
A
G
A
E
A
V
K
F
L
L
Y
Y
D
I
D
G
D
Q
D
V
N
E
Q
K
K
A
Y
I
E
R
I
G
S
E
C
R
A
E
D
I
P
F
Y
L
E
I
L
T
Y
D
E
K
I
A
D
N
A
S
P
E
F
A
K
V
K
A
-
H
K
V
N
E
A
M
K
V
F
S
K
E
R
F
G
V
D
V
L
K
V
E
--
V
P
V
-
N
M
K
F
V
E
G
F
A
D
G
E
V
L
F
T
K
E
E
A
A
Q
A
F
R
D
Q
E
A
-
S
T
D
L
P
Y
I
Y
L
S
A
-
G
V
--
S
A
K
L
F
Q
D
T
L
V
F
A
A
E
S
G
-
A
K
F
N
G
V
L
C
G
R
A
T
W
A
G
S
V
K
V
Y
I
E
E
G
P
Q
A
A
R
E
W
L
R
T
E
G
F
K
N
I
D
E
L
N
K
V
L
D
K
T
A
S
P
W
T
E
K
-
22
PsiBlast_CBE
97.17
71%
-86
- C5 -
3MHG
4
LACD2_STRP1
C:
[3-324]
-
T
L
T
E
N
K
R
K
S
M
E
K
L
S
-
V
-
D
G
V
I
S
A
L
A
F
D
Q
R
G
A
L
K
R
M
M
A
Q
H
Q
T
K
-
E
P
T
V
E
Q
-
I
E
E
-----
L
K
S
L
V
S
E
E
L
T
P
F
A
S
S
I
L
L
D
P
E
Y
G
L
P
A
S
---
R
V
-
R
S
--
E
E
A
G
L
L
L
A
Y
E
K
T
-
G
-
Y
D
A
T
T
T
S
R
L
P
---
D
C
L
D
-
V
W
S
A
K
R
I
K
E
A
G
A
E
A
V
K
F
L
L
Y
Y
D
I
D
G
D
Q
D
V
N
E
Q
K
K
A
Y
I
E
R
I
G
S
E
C
R
A
E
D
I
P
F
Y
L
E
I
L
T
Y
D
E
K
I
A
D
N
A
S
P
E
F
A
K
V
K
A
-
H
K
V
N
E
A
M
K
V
F
S
K
E
R
F
G
V
D
V
L
K
V
E
--
V
P
V
-
N
M
K
F
V
E
G
F
A
D
G
E
V
L
F
T
K
E
E
A
A
Q
A
F
R
D
Q
E
A
-
S
T
D
L
P
Y
I
Y
L
S
A
-
G
V
--
S
A
K
L
F
Q
D
T
L
V
F
A
A
E
S
G
-
A
K
F
N
G
V
L
C
G
R
A
T
W
A
G
S
V
K
V
Y
I
E
E
G
P
Q
A
A
R
E
W
L
R
T
E
G
F
K
N
I
D
E
L
N
K
V
L
D
K
T
A
S
P
W
T
E
--
21
PsiBlast_CBE
97.15
71%
-85
- C5 -
3MHG
2
LACD2_STRP1
D:
[3-326]
-
T
L
T
E
N
K
R
K
S
M
E
K
L
S
-
V
-
D
G
V
I
S
A
L
A
F
D
Q
R
G
A
L
K
R
M
M
A
Q
H
Q
T
K
-
E
P
T
V
E
Q
-
I
E
E
-----
L
K
S
L
V
S
E
E
L
T
P
F
A
S
S
I
L
L
D
P
E
Y
G
L
P
A
S
---
R
V
-
R
S
--
E
E
A
G
L
L
L
A
Y
E
K
T
-
G
-
Y
D
A
T
T
T
S
R
L
P
---
D
C
L
D
-
V
W
S
A
K
R
I
K
E
A
G
A
E
A
V
K
F
L
L
Y
Y
D
I
D
G
D
Q
D
V
N
E
Q
K
K
A
Y
I
E
R
I
G
S
E
C
R
A
E
D
I
P
F
Y
L
E
I
L
T
Y
D
E
K
I
A
D
N
A
S
P
E
F
A
K
V
K
A
-
H
K
V
N
E
A
M
K
V
F
S
K
E
R
F
G
V
D
V
L
K
V
E
--
V
P
V
-
N
M
K
F
V
E
G
F
A
D
G
E
V
L
F
T
K
E
E
A
A
Q
A
F
R
D
Q
E
A
-
S
T
D
L
P
Y
I
Y
L
S
A
-
G
V
--
S
A
K
L
F
Q
D
T
L
V
F
A
A
E
S
G
-
A
K
F
N
G
V
L
C
G
R
A
T
W
A
G
S
V
K
V
Y
I
E
E
G
P
Q
A
A
R
E
W
L
R
T
E
G
F
K
N
I
D
E
L
N
K
V
L
D
K
T
A
S
P
W
T
E
K
M
1
PsiBlast_PDB
96.98
71%
-84
- C5 -
3MHF
2
LACD2_STRP1
A:
[3-324]
-
T
L
T
E
N
K
R
K
S
M
E
K
L
S
-
V
-
D
G
V
I
S
A
L
A
F
D
Q
R
G
A
L
K
R
M
M
A
Q
H
Q
T
K
-
E
P
T
V
E
Q
-
I
E
E
-----
L
K
S
L
V
S
E
E
L
T
P
F
A
S
S
I
L
L
D
P
E
Y
G
L
P
A
S
---
R
V
-
R
S
--
E
E
A
G
L
L
L
A
Y
E
K
T
-
G
-
Y
D
A
T
T
T
S
R
L
P
---
D
C
L
D
-
V
W
S
A
K
R
I
K
E
A
G
A
E
A
V
K
F
L
L
Y
Y
D
I
D
G
D
Q
D
V
N
E
Q
K
K
A
Y
I
E
R
I
G
S
E
C
R
A
E
D
I
P
F
Y
L
E
I
L
T
Y
D
E
K
I
A
D
N
A
S
P
E
F
A
K
V
K
A
-
H
K
V
N
E
A
M
K
V
F
S
K
E
R
F
G
V
D
V
L
K
V
E
--
V
P
V
-
N
M
K
F
V
E
G
F
A
D
G
E
V
L
F
T
K
E
E
A
A
Q
A
F
R
D
Q
E
A
-
S
T
D
L
P
Y
I
Y
L
S
A
-
G
V
--
S
A
K
L
F
Q
D
T
L
V
F
A
A
E
S
G
-
A
K
F
N
G
V
L
C
G
R
A
T
W
A
G
S
V
K
V
Y
I
E
E
G
P
Q
A
A
R
E
W
L
R
T
E
G
F
K
N
I
D
E
L
N
K
V
L
D
K
T
A
S
P
W
T
E
--
26
HHSearch
96.97
72%
-84
- C5 -
3IV3
11
LACD2_STRMU
A:
[4-329]
M
I
L
S
Q
Q
K
Y
N
Y
L
A
K
V
S
D
S
-
N
G
V
I
S
A
L
A
F
D
Q
R
G
A
L
K
C
L
M
A
Q
Y
Q
M
K
-
E
P
T
V
A
Q
-
M
E
E
-----
L
K
V
L
V
S
E
E
L
T
P
Y
A
S
S
I
L
L
D
P
E
Y
G
L
P
A
A
---
Q
A
-
R
D
--
R
E
A
G
L
L
L
A
Y
E
K
T
-
G
-
Y
D
A
N
T
T
S
R
L
P
---
D
C
L
V
-
D
W
S
I
K
R
L
K
E
A
G
A
D
A
V
K
F
L
L
Y
Y
D
V
D
G
D
P
Q
V
N
V
Q
K
Q
A
Y
I
E
R
I
G
S
E
C
Q
A
E
D
I
P
F
F
L
E
I
L
T
Y
D
E
T
I
S
N
N
S
S
V
E
F
A
K
V
K
V
-
H
K
V
N
D
A
M
K
V
F
S
A
E
R
F
G
I
D
V
L
K
V
E
--
V
P
V
-
N
M
V
Y
V
E
G
F
A
E
G
E
V
V
Y
S
K
E
E
A
A
Q
A
F
R
E
Q
E
A
-
S
T
D
L
P
Y
I
Y
L
S
A
-
G
V
--
S
A
E
L
F
Q
E
T
L
V
F
A
H
K
A
G
-
A
K
F
N
G
V
L
C
G
R
A
T
W
A
G
S
V
Q
V
Y
M
E
E
G
K
E
A
A
R
Q
W
L
R
T
S
G
L
Q
N
I
N
E
L
N
K
V
L
K
T
T
A
S
P
W
T
E
K
V
23
PsiBlast_CBE
96.95
71%
-85
- C5 -
3MHG
2
LACD2_STRP1
B:
[2-324]
I
T
L
T
E
N
K
R
K
S
M
E
K
L
S
-
V
-
D
G
V
I
S
A
L
A
F
D
Q
R
G
A
L
K
R
M
M
A
Q
H
Q
T
K
-
E
P
T
V
E
Q
-
I
E
E
-----
L
K
S
L
V
S
E
E
L
T
P
F
A
S
S
I
L
L
D
P
E
Y
G
L
P
A
S
---
R
V
-
R
S
--
E
E
A
G
L
L
L
A
Y
E
K
T
-
G
-
Y
D
A
T
T
T
S
R
L
P
---
D
C
L
D
-
V
W
S
A
K
R
I
K
E
A
G
A
E
A
V
K
F
L
L
Y
Y
D
I
D
G
D
Q
D
V
N
E
Q
K
K
A
Y
I
E
R
I
G
S
E
C
R
A
E
D
I
P
F
Y
L
E
I
L
T
Y
D
E
K
I
A
D
N
A
S
P
E
F
A
K
V
K
A
-
H
K
V
N
E
A
M
K
V
F
S
K
E
R
F
G
V
D
V
L
K
V
E
--
V
P
V
-
N
M
K
F
V
E
G
F
A
D
G
E
V
L
F
T
K
E
E
A
A
Q
A
F
R
D
Q
E
A
-
S
T
D
L
P
Y
I
Y
L
S
A
-
G
V
--
S
A
K
L
F
Q
D
T
L
V
F
A
A
E
S
G
-
A
K
F
N
G
V
L
C
G
R
A
T
W
A
G
S
V
K
V
Y
I
E
E
G
P
Q
A
A
R
E
W
L
R
T
E
G
F
K
N
I
D
E
L
N
K
V
L
D
K
T
A
S
P
W
T
E
--
25
PsiBlast_CBE
96.88
71%
-84
- C5 -
3MHF
1
LACD2_STRP1
C:
[2-325]
I
T
L
T
E
N
K
R
K
S
M
E
K
L
S
-
V
-
D
G
V
I
S
A
L
A
F
D
Q
R
G
A
L
K
R
M
M
A
Q
H
Q
T
K
-
E
P
T
V
E
Q
-
I
E
E
-----
L
K
S
L
V
S
E
E
L
T
P
F
A
S
S
I
L
L
D
P
E
Y
G
L
P
A
S
---
R
V
-
R
S
--
E
E
A
G
L
L
L
A
Y
E
K
T
-
G
-
Y
D
A
T
T
T
S
R
L
P
---
D
C
L
D
-
V
W
S
A
K
R
I
K
E
A
G
A
E
A
V
K
F
L
L
Y
Y
D
I
D
G
D
Q
D
V
N
E
Q
K
K
A
Y
I
E
R
I
G
S
E
C
R
A
E
D
I
P
F
Y
L
E
I
L
T
Y
D
E
K
I
A
D
N
A
S
P
E
F
A
K
V
K
A
-
H
K
V
N
E
A
M
K
V
F
S
K
E
R
F
G
V
D
V
L
K
V
E
--
V
P
V
-
N
M
K
F
V
E
G
F
A
D
G
E
V
L
F
T
K
E
E
A
A
Q
A
F
R
D
Q
E
A
-
S
T
D
L
P
Y
I
Y
L
S
A
-
G
V
--
S
A
K
L
F
Q
D
T
L
V
F
A
A
E
S
G
-
A
K
F
N
G
V
L
C
G
R
A
T
W
A
G
S
V
K
V
Y
I
E
E
G
P
Q
A
A
R
E
W
L
R
T
E
G
F
K
N
I
D
E
L
N
K
V
L
D
K
T
A
S
P
W
T
E
K
-
7
PsiBlast_PDB
96.46
67%
-85
- C5 -
3MYO
-
LACD1_STRP1
A:
[2-325]
-
T
I
T
A
N
K
R
H
Y
L
E
K
V
S
H
Q
--
G
I
I
S
A
L
A
F
D
Q
R
G
A
L
K
Q
M
M
A
A
H
Q
E
G
-
E
A
T
V
T
Q
-
I
E
T
-----
L
K
V
L
V
S
E
E
L
T
P
Y
A
S
S
I
L
L
D
P
E
Y
G
L
L
A
T
---
K
V
-
R
A
--
N
Q
T
G
L
L
L
A
Y
E
K
T
-
G
-
Y
D
A
T
T
T
S
R
L
P
---
D
C
L
V
-
E
W
S
V
K
R
L
K
A
A
G
A
D
A
I
K
F
L
L
Y
Y
D
V
D
G
D
E
Q
I
N
L
Q
K
Q
A
Y
I
E
R
I
G
S
E
C
T
A
E
D
I
P
F
F
L
E
L
L
S
Y
D
E
R
I
S
D
N
N
S
A
A
Y
A
K
L
K
P
-
H
K
V
N
G
A
M
S
V
F
S
D
K
R
F
G
V
D
V
L
K
V
E
--
V
P
V
-
N
M
A
Y
V
E
G
F
T
E
G
E
V
H
Y
S
Q
A
E
A
I
K
A
F
Q
D
Q
E
A
-
A
S
H
L
P
Y
I
Y
L
S
A
-
G
V
--
S
A
K
L
F
Q
E
T
L
Y
F
A
A
A
A
G
-
A
Q
F
S
G
V
L
C
G
R
A
T
W
A
G
S
V
P
V
Y
I
T
K
G
E
D
E
A
R
K
W
L
C
T
E
G
F
Q
N
I
D
E
L
N
R
V
L
E
E
T
A
S
P
W
T
E
K
I
5
PsiBlast_PDB
96.34
70%
-84
- C5 -
3IV3
11
LACD2_STRMU
A:
[5-329]
-
I
L
S
Q
Q
K
Y
N
Y
L
A
K
V
S
D
S
-
N
G
V
I
S
A
L
A
F
D
Q
R
G
A
L
K
C
L
M
A
Q
Y
Q
M
K
-
E
P
T
V
A
Q
-
M
E
E
-----
L
K
V
L
V
S
E
E
L
T
P
Y
A
S
S
I
L
L
D
P
E
Y
G
L
P
A
A
---
Q
A
-
R
D
--
R
E
A
G
L
L
L
A
Y
E
K
T
-
G
-
Y
D
A
N
T
T
S
R
L
P
---
D
C
L
V
-
D
W
S
I
K
R
L
K
E
A
G
A
D
A
V
K
F
L
L
Y
Y
D
V
D
G
D
P
Q
V
N
V
Q
K
Q
A
Y
I
E
R
I
G
S
E
C
Q
A
E
D
I
P
F
F
L
E
I
L
T
Y
D
E
T
I
S
N
N
S
S
V
E
F
A
K
V
K
V
-
H
K
V
N
D
A
M
K
V
F
S
A
E
R
F
G
I
D
V
L
K
V
E
--
V
P
V
-
N
M
V
Y
V
E
G
F
A
E
G
E
V
V
Y
S
K
E
E
A
A
Q
A
F
R
E
Q
E
A
-
S
T
D
L
P
Y
I
Y
L
S
A
-
G
V
--
S
A
E
L
F
Q
E
T
L
V
F
A
H
K
A
G
-
A
K
F
N
G
V
L
C
G
R
A
T
W
A
G
S
V
Q
V
Y
M
E
E
G
K
E
A
A
R
Q
W
L
R
T
S
G
L
Q
N
I
N
E
L
N
K
V
L
K
T
T
A
S
P
W
T
E
K
V
24
PsiBlast_CBE
95.51
71%
-84
- C5 -
3MHF
1
LACD2_STRP1
D:
[2-324]
I
T
L
T
E
N
K
R
K
S
M
E
K
L
S
-
V
-
D
G
V
I
S
A
L
A
F
D
Q
R
G
A
L
K
R
M
M
A
Q
H
Q
T
K
-
E
P
T
V
E
Q
-
I
E
E
-----
L
K
S
L
V
S
E
E
L
T
P
F
A
S
S
I
L
L
D
P
E
Y
G
L
P
A
S
---
R
V
-
R
S
--
E
E
A
G
L
L
L
A
Y
E
K
T
-
G
-
Y
D
A
T
T
T
S
R
L
P
---
D
C
L
D
-
V
W
S
A
K
R
I
K
E
A
G
A
E
A
V
K
F
L
L
Y
Y
D
I
D
G
D
Q
D
V
N
E
Q
K
K
A
Y
I
E
R
I
G
S
E
C
R
A
E
D
I
P
F
Y
L
E
I
L
T
Y
D
E
K
I
A
D
N
A
S
P
E
F
A
K
V
K
A
-
H
K
V
N
E
A
M
K
V
F
S
K
E
R
F
G
V
D
V
L
K
V
E
--
V
P
V
-
N
M
K
F
V
E
G
F
A
D
G
E
V
L
F
T
K
E
E
A
A
Q
A
F
R
D
Q
E
A
-
S
T
D
L
P
Y
I
Y
L
S
A
-
G
V
--
S
A
K
L
F
Q
D
T
L
V
F
A
A
E
S
G
-
A
K
F
N
G
V
L
C
G
R
A
T
W
A
G
S
V
K
V
Y
I
E
E
G
P
Q
A
A
R
E
W
L
R
T
E
G
F
K
N
I
D
E
L
N
K
V
L
D
K
T
A
S
P
W
T
E
--
4
PsiBlast_PDB
66.39
72%
17
- C5 -
3MYP
-
LACD_STAAC
A:
[4-324]
---
S
N
Q
K
I
A
S
I
E
Q
L
S
N
N
-
E
G
I
I
S
A
L
A
F
D
Q
R
G
A
L
K
R
M
M
A
K
H
Q
T
E
-
E
P
T
V
A
Q
-
I
E
Q
-----
L
K
V
L
V
A
E
E
L
T
Q
Y
A
S
S
I
L
L
D
P
E
Y
G
L
P
A
S
---
D
A
-
R
N
--
K
D
C
G
L
L
L
A
Y
E
K
T
-
G
-
Y
D
V
N
A
K
G
R
L
P
---
D
C
L
V
-
E
W
S
A
K
R
L
K
E
Q
G
A
N
A
V
K
F
L
L
Y
Y
D
V
D
D
A
E
E
I
N
I
Q
K
K
A
Y
I
E
R
I
G
S
E
C
V
A
E
D
I
P
F
F
L
E
V
L
T
Y
D
D
N
I
P
D
N
G
S
V
E
F
A
K
V
K
P
-
R
K
V
N
E
A
M
K
L
F
S
E
P
R
F
N
V
D
V
L
K
V
E
--
V
P
V
-
N
M
K
Y
V
E
G
F
A
E
G
E
V
V
Y
T
K
E
E
A
A
Q
H
F
K
D
Q
D
A
-
A
T
H
L
P
Y
I
Y
L
S
A
-
G
V
--
S
A
E
L
F
Q
E
T
L
K
F
A
H
E
A
G
-
A
K
F
N
G
V
L
C
G
R
A
T
W
S
G
A
V
Q
V
Y
I
E
Q
G
E
D
A
A
R
E
W
L
R
T
T
G
F
K
N
I
D
D
L
N
K
V
L
K
D
T
A
T
S
W
K
Q
--
27
HHSearch
65.98
24%
-67
- C5 -
1TO3
12
SQUT_SALTY
A:
[3-293]
-----
L
N
N
Y
T
I
K
D
I
T
R
A
-
S
G
G
F
A
M
L
A
V
D
Q
R
E
A
M
R
L
M
F
A
A
A
G
A
K
T
P
V
A
D
S
V
-
L
T
D
-----
F
K
V
N
A
A
K
I
L
S
P
Y
A
S
A
V
L
L
D
Q
Q
F
C
Y
R
Q
A
---
V
E
Q
N
A
VA
K
S
C
A
M
I
V
A
A
D
D
F
-
I
-
P
G
N
G
I
P
V
D
N
V
---
V
L
D
K
-
K
I
N
A
Q
A
V
K
R
D
G
A
K
A
L
K
L
L
V
L
W
R
S
D
E
D
---
A
Q
Q
R
L
N
M
V
K
E
F
N
E
L
C
H
S
N
G
L
L
S
I
I
E
P
V
V
R
P
P
R
C
G
D
-------
K
F
D
R
E
Q
A
I
I
D
A
A
K
E
L
G
--
D
S
G
A
D
L
Y
K
V
E
--
M
P
L
-
Y
G
K
---
G
A
--------
R
S
D
L
L
T
A
S
Q
R
L
N
G
-
H
I
N
M
P
W
V
I
L
S
S
-
G
V
--
D
E
K
L
F
P
R
A
V
R
V
A
M
E
A
G
-
A
--
S
G
F
L
A
G
R
A
V
W
S
S
V
I
G
L
P
D
-
T
-----
E
L
M
L
R
D
V
S
A
P
K
L
Q
R
L
G
E
I
V
D
E
M
M
G
K
R
----
8
PsiBlast_PDB
65.37
26%
-77
- C5 -
1TO3
11
SQUT_SALTY
A:
[8-262]
----------
I
K
D
I
T
R
A
-
S
G
G
F
A
M
L
A
V
D
Q
R
E
A
M
R
L
M
F
A
A
A
G
A
K
-
T
P
V
A
D
S
V
L
T
D
-----
F
K
V
N
A
A
K
I
L
S
P
Y
A
S
A
V
L
L
D
Q
Q
F
C
Y
R
Q
A
V
E
Q
N
A
-
V
A
--
K
S
C
A
M
I
V
A
A
D
------
D
F
I
P
G
N
G
I
P
VDN
V
V
L
D
K
K
I
N
A
Q
A
V
K
R
D
G
A
K
A
L
K
L
L
V
L
W
---
R
S
D
E
D
A
Q
Q
R
L
N
M
V
K
E
F
N
E
L
C
H
S
N
G
L
L
S
I
I
E
P
V
V
R
P
P
R
C
G
D
K
F
D
R
E
Q
A
-------
I
I
D
A
A
K
E
L
G
D
S
--
G
A
D
L
Y
K
V
E
--
M
P
L
--------
Y
G
K
G
----
A
R
S
D
L
L
T
A
S
Q
R
L
N
G
-
H
I
N
M
P
W
V
I
L
S
S
-
G
V
--
D
E
K
L
F
P
R
A
V
R
V
A
M
E
A
G
-
A
--
S
G
F
L
A
G
R
A
V
W
S
S
V
I
G
L
P
D
T
E
L
M
L
R
D
V
S
A
P
K
L
Q
R
L
G
E
I
V
D
E
M
M
G
K
R
----------
47
Fugue
52.59
15%
-60
- C5 -
1OJX
-
ALF1_THETK
A:
[3-252]
----
N
L
T
E
K
F
L
R
I
F
A
R
R
-
G
K
S
I
I
L
A
-------
Y
D
H
G
I
E
H
G
P
A
D
-
F
M
D
N
P
D
-
S
A
D
-----
P
E
Y
I
L
R
L
A
R
D
A
G
F
D
G
V
V
F
Q
---
R
G
I
A
E
---
K
Y
-
Y
D
--
G
S
V
P
L
I
L
K
L
----
N
-
G
K
T
T
L
Y
N
G
E
P
---
V
S
V
A
-
N
C
S
V
E
E
A
V
S
L
G
A
S
A
V
G
Y
T
I
Y
P
G
----
S
G
F
E
W
K
M
F
E
E
L
A
R
I
K
R
D
A
V
K
F
D
L
P
L
V
V
W
S
Y
P
R
G
G
K
V
V
N
E
T
A
P
E
I
V
A
Y
A
A
-
R
I
A
L
E
L
---------
G
A
D
A
M
K
I
K
--
Y
T
-------------------
G
D
P
K
T
F
S
W
A
V
K
V
-
A
G
K
V
P
-
V
L
M
S
G
-
G
P
--
K
T
K
T
E
E
D
F
L
K
Q
V
E
G
V
L
E
A
G
A
L
G
I
A
V
G
R
N
V
W
----------------------
Q
R
R
D
A
L
K
F
A
R
A
L
A
E
L
V
Y
G
-----
32
HHSearch
51.94
15%
-69
- C5 -
2QJG
1
ADHS_METJA
A:
[6-246]
D
I
K
N
L
G
K
L
V
R
L
E
R
I
F
N
R
E
S
E
K
T
V
I
V
P
M
D
H
G
V
S
N
G
P
I
------------
K
G
-
L
I
D
-----
I
R
K
T
V
N
D
V
A
E
G
G
A
N
A
V
L
L
H
K
G
I
V
R
H
G
H
---
R
G
-
Y
G
--
K
D
V
G
L
I
I
H
L
S
G
G
-
T
-
A
I
S
---
P
N
P
L
---
K
K
V
I
-
V
T
T
V
E
E
A
I
R
M
G
A
D
A
V
S
I
H
V
N
V
G
S
D
E
D
----
W
E
A
Y
R
D
L
G
M
I
A
E
T
C
E
Y
W
G
M
P
L
I
A
M
M
Y
P
R
G
K
H
I
Q
-------
N
E
R
D
P
-
E
L
V
A
H
A
A
R
L
G
A
--
E
L
G
A
D
I
V
K
T
S
--
Y
T
G
-
D
I
-------------------
D
S
F
R
D
V
V
K
-
G
C
P
A
P
V
V
V
A
G
G
-
P
K
TN
T
D
E
E
F
L
Q
M
I
K
D
A
M
E
A
G
-
A
--
A
G
V
A
V
G
R
N
I
F
Q
H
D
D
V
V
G
I
T
R
A
V
C
K
I
V
H
E
N
A
D
V
E
E
A
L
K
E
I
R
K
--------------
30
HHSearch
48.82
16%
-57
- C5 -
1W8S
1
ALF1_THETK
A:
[3-240]
-----
N
L
T
E
K
F
L
R
I
F
A
R
-
R
G
K
S
I
I
L
A
Y
D
H
G
I
E
H
G
P
A
------------
D
F
-
M
D
N
PDSAD
P
E
Y
I
L
R
L
A
R
D
A
G
F
D
G
V
V
F
Q
R
G
I
A
E
-
K
Y
---
Y
---
D
--
G
S
V
P
L
I
L
K
L
N
G
K
T
T
-
L
Y
N
----
G
E
P
---
V
S
V
A
-
N
C
S
V
E
E
A
V
S
L
G
A
S
A
V
G
Y
T
I
Y
P
G
S
G
F
----
E
W
K
M
F
E
E
L
A
R
I
K
R
D
A
V
K
F
D
L
P
L
V
V
E
S
F
P
R
G
G
K
V
V
N
-------
E
T
A
P
-
E
I
V
A
Y
A
A
R
I
A
L
--
E
L
G
A
D
A
M
K
I
K
--
Y
T
G
-
D
P
-------------------
K
T
F
S
W
A
V
K
V
A
G
K
V
P
V
L
M
S
G
G
-
P
K
TK
T
E
E
D
F
L
K
Q
V
E
G
V
L
E
A
G
-
A
--
L
G
I
A
V
G
R
N
V
W
Q
R
R
D
A
L
K
F
A
R
A
L
A
E
L
V
Y
----------------------------
29
HHSearch
45.92
14%
-69
- C5 -
3GLC
1
LSRF_ECOLI
A:
[35-266]
-
A
L
D
W
G
M
Q
S
R
L
S
R
I
F
N
P
K
T
G
K
T
V
M
L
A
F
D
H
G
Y
F
Q
G
P
T
------------
T
G
-
L
E
R
-----
I
D
I
N
I
A
P
L
F
-
E
H
A
D
V
L
M
C
T
R
G
I
L
R
-
S
V
---
V
P
-
P
A
--
T
N
R
P
V
V
L
R
A
S
G
A
-
N
S
I
L
A
----
E
L
S
---
N
E
A
V
-
A
L
S
M
D
D
A
V
R
L
N
S
C
A
V
A
A
Q
V
Y
I
G
S
E
Y
----
E
H
Q
S
I
K
N
I
I
Q
L
V
D
A
G
M
K
V
G
M
P
T
M
A
V
T
G
V
--------------
V
R
D
Q
-
R
Y
F
S
L
A
T
R
I
A
A
--
E
M
G
A
Q
I
I
K
T
Y
--
Y
V
E
----------------------
K
G
F
E
R
I
V
A
-
G
C
P
V
P
I
V
I
A
G
G
K
K
L
--
P
E
R
E
A
L
E
M
C
W
Q
A
I
D
Q
G
-
A
--
S
G
V
D
M
G
R
N
I
F
Q
S
D
H
P
V
A
M
M
K
A
V
Q
A
V
V
H
H
N
E
T
A
D
R
A
Y
E
L
Y
L
S
E
-------------
33
HHSearch
42.17
14%
-37
* C5 *
3NDO
4
?
A:
[9-230]
------------------
T
R
A
Q
V
A
A
L
V
D
H
T
L
L
K
-
P
E
------------
A
T
-
P
S
D
-----
V
T
A
L
V
D
E
A
A
D
L
G
V
F
A
V
C
V
S
P
P
L
V
S
-
V
A
---
A
G
V
A
P
--
S
G
L
A
I
A
A
V
A
----
G
-
F
-
P
S
--
G
K
H
V
---
P
G
I
K
-
A
T
E
A
E
L
A
V
A
A
G
A
T
E
I
D
M
V
I
D
V
G
A
A
L
A
G
D
-
L
D
A
V
S
A
D
I
T
A
V
R
K
A
V
R
A
A
T
L
K
V
I
V
E
S
A
A
L
L
E
F
-----------
S
G
E
-
P
L
L
A
D
V
C
R
V
A
R
--
D
A
G
A
D
F
V
K
T
S
TG
F
H
P
S
G
G
A
------------
S
V
Q
-
A
V
E
I
M
A
R
T
V
G
--
E
R
L
G
V
K
A
S
G
G
-
I
R
--
T
A
----
E
Q
A
A
A
M
L
D
A
G
-
A
T
R
L
G
L
S
G
S
R
A
V
L
D
G
F
G
S
A
---------------------------------------