@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1387: (2015-12-07 )
MTKISWTGFSKKSPEERIHYLEEQDFLADSSLEIVTNQDLLSLSLANQMAENVIGRIALPFSLVPDVLVNGKVYQVPYVTEEPSVVAAASFAAKIIKRSGGFLTTVHNRKMIGQVALYDVQDSQHAKESILNQKQQLLEIANAAHPSIVKRGGGACDLTIEIKEGFLIVYLMVDTKEAMGANMVNTMMEALSSPLEDISKGKSLMSILSNYATESLVTATCRVDLRFLSRQKEEAIKLAQKMTMASQLAQVDPYRASTHNKGIFNGIDAIVLATGNDWRAIEAGAHTYAVKDGQYRGLSKWSYKVDDNFLEGTLTLPMPVATKGGSIGINPSVQLAHDLLGRPNAKELASIVLSIGLAQNFAALKALVSTGIQAGHMKLQAKSLALLAGAKEEQISEVVKQLLDSKHMNLETAQKIVNKLTKSKKRI
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160-----.---.-----.---....170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
K
I
S
WTGFSKK
S
P
E
E
R
I
H
Y
L
E
E
Q
DFLADS
S
L
E
I
V
TNQ
D
L
L
S
L
S
L
A
N
Q
M
A
E
N
V
I
G
R
IAL
P
F
SLV
P
D
V
LVNG
K
V
Y
QVPYVTEEP
S
V
V
A
A
A
S
F
A
A
K
I
I
K
RSGG
F
L
T
T
VHNR
K
M
I
G
Q
V
A
L
Y
DVQD
S
Q
H
A
K
E
S
I
L
N
Q
K
Q
Q
L
L
E
I
A
NAA
H
P
S
I
V
KRGG
G
A
C
D
L
T
I
E
I
-----K---E-----
G
---
F
L
I
V
Y
L
M
VD
T
K
E
AM
G
A
N
M
V
N
T
M
M
E
A
L
S
S
P
L
E
D
I
S
K
G
K
S
L
M
S
I
L
S
N
YAT
E
S
L
V
T
A
T
C
R
V
D
L
R
F
L
S
R
Q
K
E
E
A
I
K
L
A
Q
K
M
T
M
A
S
Q
L
A
QVDPYRASTHNKGIFNGI
D
A
I
V
L
ATGND
W
R
A
I
EAGA
H
T
Y
A
VKDGQYRGLS
K
W
S
Y
KVDDNFLEG
T
L
TLP
M
P
VATKGGSIGINP
S
V
Q
L
A
H
D
LLGRP
N
A
K
E
L
A
S
I
V
L
S
I
G
L
A
Q
N
F
A
A
L
K
A
L
V
S
TGIQAG
H
M
K
L
Q
A
K
S
L
A
LLAGA
K
E
E
Q
I
S
E
V
V
K
Q
L
L
DSKHM
N
L
E
T
A
Q
K
I
V
N
K
L
T
K
SKKRI
2
PsiBlast_PDB
99.85
63%
-108
- C3 -
3QAU
26
?
A:
[37-456]
---
I
S
W
N
G
F
S
K
K
S
Y
Q
E
R
L
E
L
L
K
A
Q
A
L
L
S
P
E
R
Q
A
S
L
E
K
D
E
Q
M
S
V
T
V
A
D
Q
L
S
E
N
V
V
G
T
F
S
L
P
Y
S
L
V
P
E
V
L
V
N
G
Q
E
Y
T
V
P
Y
V
T
E
E
P
S
V
V
A
A
A
S
Y
A
S
K
I
I
K
R
A
G
G
F
T
T
Q
V
H
Q
R
Q
M
I
G
Q
V
A
L
Y
Q
V
A
N
P
K
L
A
Q
E
K
I
A
S
K
K
A
E
L
L
E
L
A
N
Q
A
Y
P
S
I
V
K
R
G
G
G
A
R
D
L
H
V
E
Q
-----
I
---
K
-----
G
EP
D
F
L
V
V
Y
I
H
V
D
T
Q
E
A
M
G
A
N
M
L
N
T
M
L
E
A
L
K
P
V
L
E
E
L
S
Q
G
Q
S
L
M
G
I
L
S
N
Y
A
T
D
S
L
V
T
A
S
C
R
I
A
F
R
Y
L
S
R
Q
K
D
Q
G
R
E
I
A
E
K
I
A
L
A
S
Q
F
A
Q
A
D
P
Y
R
A
A
T
H
N
K
G
I
F
N
G
I
D
A
I
L
I
A
T
G
N
D
W
R
A
I
E
A
G
A
H
A
F
A
S
R
D
G
R
Y
Q
G
L
S
C
W
T
L
D
L
E
R
E
E
L
V
G
E
M
T
L
P
M
P
V
A
T
K
G
S
S
I
G
L
N
P
R
V
A
L
S
H
D
L
L
G
N
P
S
A
R
E
L
A
Q
I
I
V
S
I
G
L
A
Q
N
F
A
A
L
K
A
L
V
S
T
G
I
Q
Q
G
H
M
K
L
Q
A
K
S
L
A
L
L
A
G
A
S
E
S
E
V
A
P
L
V
E
R
L
I
S
D
K
T
F
N
L
E
T
A
Q
R
Y
L
E
N
L
R
------
32
HHSearch
93.57
63%
-102
- C3 -
3QAE
25
?
A:
[37-406]
---
I
S
W
N
G
F
S
K
K
S
Y
Q
E
R
L
E
L
L
K
A
Q
A
L
L
S
P
E
R
Q
A
S
L
E
K
D
E
Q
M
S
V
T
V
A
D
Q
L
S
E
N
V
V
G
T
F
S
L
P
Y
S
L
V
P
E
V
L
V
N
G
Q
E
Y
T
V
P
Y
V
T
E
E
P
S
V
V
A
A
A
S
Y
A
S
K
I
I
K
R
A
G
G
F
T
T
Q
V
H
Q
R
Q
M
I
G
Q
V
A
L
Y
Q
V
A
N
P
K
L
A
Q
E
K
I
A
S
K
K
A
E
L
L
E
L
A
N
Q
A
Y
P
S
I
V
K
R
G
G
G
A
R
D
L
H
V
E
Q
-----
I
K
G
E
P
-----
D
---
F
L
V
V
Y
I
H
V
D
T
Q
E
A
M
G
A
N
M
L
N
T
M
L
E
A
L
K
P
V
L
E
E
L
S
Q
G
Q
S
L
M
G
I
L
S
N
Y
A
T
D
S
L
V
T
A
S
C
R
I
A
F
R
Y
L
S
R
Q
K
D
Q
G
R
E
I
A
E
K
I
A
L
A
S
Q
F
A
Q
A
D
P
Y
R
A
A
T
H
N
K
G
I
F
N
G
I
D
A
I
L
I
A
T
G
N
D
W
R
A
I
E
A
G
A
H
A
F
A
S
R
D
G
R
Y
Q
G
L
S
C
W
T
L
D
L
E
R
E
E
L
V
G
E
M
T
L
P
M
P
V
A
T
K
G
S
S
I
G
L
N
P
R
V
A
L
S
H
D
L
L
G
N
P
S
A
R
E
L
A
Q
I
I
V
S
I
G
L
A
Q
N
F
A
A
L
K
A
L
V
S
T
---------------------------------------------------------
1
PsiBlast_PDB
93.47
63%
-103
- C3 -
3QAE
25
?
A:
[37-406]
---
I
S
W
N
G
F
S
K
K
S
Y
Q
E
R
L
E
L
L
K
A
Q
A
L
L
S
P
E
R
Q
A
S
L
E
K
D
E
Q
M
S
V
T
V
A
D
Q
L
S
E
N
V
V
G
T
F
S
L
P
Y
S
L
V
P
E
V
L
V
N
G
Q
E
Y
T
V
P
Y
V
T
E
E
P
S
V
V
A
A
A
S
Y
A
S
K
I
I
K
R
A
G
G
F
T
T
Q
V
H
Q
R
Q
M
I
G
Q
V
A
L
Y
Q
V
A
N
P
K
L
A
Q
E
K
I
A
S
K
K
A
E
L
L
E
L
A
N
Q
A
Y
P
S
I
V
K
R
G
G
G
A
R
D
L
H
V
E
Q
-----
I
---
K
-----
G
EP
D
F
L
V
V
Y
I
H
V
D
T
Q
E
A
M
G
A
N
M
L
N
T
M
L
E
A
L
K
P
V
L
E
E
L
S
Q
G
Q
S
L
M
G
I
L
S
N
Y
A
T
D
S
L
V
T
A
S
C
R
I
A
F
R
Y
L
S
R
Q
K
D
Q
G
R
E
I
A
E
K
I
A
L
A
S
Q
F
A
Q
A
D
P
Y
R
A
A
T
H
N
K
G
I
F
N
G
I
D
A
I
L
I
A
T
G
N
D
W
R
A
I
E
A
G
A
H
A
F
A
S
R
D
G
R
Y
Q
G
L
S
C
W
T
L
D
L
E
R
E
E
L
V
G
E
M
T
L
P
M
P
V
A
T
K
G
S
S
I
G
L
N
P
R
V
A
L
S
H
D
L
L
G
N
P
S
A
R
E
L
A
Q
I
I
V
S
I
G
L
A
Q
N
F
A
A
L
K
A
L
V
S
T
---------------------------------------------------------
3
PsiBlast_PDB
83.80
39%
-93
- C3 -
1QAX
2
MVAA_PSEMV
A:
[10-409]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
F
ADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
I
Q
R
G
H
M
A
L
H
A
R
N
I
A
V
V
A
G
A
R
G
D
E
V
D
W
V
A
R
Q
L
V
E
Y
H
D
V
R
A
D
R
A
V
A
L
L
K
Q
K
R
G
Q
----
11
PsiBlast_PDB
83.74
39%
-97
- C3 -
4I6W
5
MVAA_PSEMV
A:
[10-375]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
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T
A
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F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
---------------------------------------------------------
9
PsiBlast_PDB
83.72
39%
-97
- C3 -
4I64
3
MVAA_PSEMV
A:
[10-375]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
---------------------------------------------------------
8
PsiBlast_PDB
83.66
39%
-97
- C3 -
4I56
5
MVAA_PSEMV
A:
[10-375]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
---------------------------------------------------------
22
PsiBlast_CBE
83.51
39%
-97
- C3 -
4I6W
5
MVAA_PSEMV
B:
[10-378]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
I
Q
------------------------------------------------------
10
PsiBlast_PDB
83.51
39%
-99
- C3 -
4I6A
2
MVAA_PSEMV
A:
[10-378]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
I
Q
------------------------------------------------------
12
PsiBlast_PDB
83.38
39%
-95
- C3 -
4I6Y
7
MVAA_PSEMV
A:
[10-376]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
--------------------------------------------------------
5
PsiBlast_PDB
83.19
39%
-97
- C3 -
1R31
3
MVAA_PSEMV
A:
[10-378]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
I
Q
------------------------------------------------------
6
PsiBlast_PDB
83.12
39%
-94
- C3 -
1R7I
4
MVAA_PSEMV
A:
[10-374]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
F
ADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
----------------------------------------------------------
26
PsiBlast_CBE
83.09
39%
-95
- C3 -
4I4B
5
MVAA_PSEMV
B:
[10-378]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
I
Q
------------------------------------------------------
21
PsiBlast_CBE
83.04
39%
-93
- C3 -
4I6Y
8
MVAA_PSEMV
B:
[10-379]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
I
Q
R
-----------------------------------------------------
23
PsiBlast_CBE
82.89
39%
-97
- C3 -
4I6A
2
MVAA_PSEMV
B:
[10-378]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
I
Q
------------------------------------------------------
31
PsiBlast_CBE
82.80
39%
-95
- C3 -
1QAX
2
MVAA_PSEMV
B:
[10-375]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
---------------------------------------------------------
24
PsiBlast_CBE
82.68
39%
-97
- C3 -
4I64
3
MVAA_PSEMV
B:
[10-378]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
I
Q
------------------------------------------------------
43
Fugue
82.67
40%
-94
* C3 *
1QAY
2
MVAA_PSEMV
A:
[4-387]
D
S
R
L
P
--
A
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
-----
F
---
A
DTPR
G
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
K
D
-
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
I
Q
R
G
H
M
A
L
H
A
R
---------------------------------------------
28
PsiBlast_CBE
82.36
39%
-95
- C3 -
1R7I
2
MVAA_PSEMV
B:
[10-377]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
I
-------------------------------------------------------
30
PsiBlast_CBE
82.34
39%
-96
- C3 -
1QAY
2
MVAA_PSEMV
B:
[10-377]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
I
-------------------------------------------------------
29
PsiBlast_CBE
82.28
39%
-94
- C3 -
1R31
4
MVAA_PSEMV
B:
[10-377]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
I
-------------------------------------------------------
27
PsiBlast_CBE
82.03
39%
-97
- C3 -
1T02
2
MVAA_PSEMV
B:
[10-377]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
I
-------------------------------------------------------
25
PsiBlast_CBE
81.90
39%
-97
- C3 -
4I56
4
MVAA_PSEMV
B:
[10-378]
--------
F
R
N
L
S
P
A
A
R
L
D
H
I
G
Q
L
L
G
L
S
H
D
D
V
S
L
L
A
N
A
G
A
L
P
M
D
I
A
N
G
M
I
E
N
V
I
G
T
F
E
L
P
Y
A
V
A
S
N
F
Q
I
N
G
R
D
V
L
V
P
L
V
V
E
E
P
S
I
V
A
A
A
S
Y
M
A
K
L
A
R
A
N
G
G
F
T
T
S
S
S
A
P
L
M
H
A
Q
V
Q
I
V
G
I
Q
D
P
L
N
A
R
L
S
L
L
R
R
K
D
E
I
I
E
L
A
N
R
K
D
Q
L
L
N
S
L
G
G
G
C
R
D
I
E
V
H
T
FADTP
R
---
G
-----
P
---
M
L
V
A
H
L
I
V
D
V
R
D
A
M
G
A
N
T
V
N
T
M
A
E
A
V
A
P
L
M
E
A
I
T
G
G
Q
V
R
L
R
I
L
S
N
L
A
D
L
R
L
A
R
A
Q
V
R
I
T
P
Q
Q
L
E
T
A
E
F
S
G
E
A
V
I
E
G
I
L
D
A
Y
A
F
A
A
V
D
P
Y
R
A
A
T
H
N
K
G
I
M
N
G
I
D
P
L
I
V
A
T
G
N
D
W
R
A
V
E
A
G
A
H
A
Y
A
C
R
S
G
H
Y
G
S
L
T
T
W
E
-
K
D
N
N
G
H
L
V
G
T
L
E
M
P
M
P
V
G
L
V
G
G
A
T
K
T
H
P
L
A
Q
L
S
L
R
I
L
G
V
K
T
A
Q
A
L
A
E
I
A
V
A
V
G
L
A
Q
N
L
G
A
M
R
A
L
A
T
E
G
I
Q
------------------------------------------------------