@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1423: (2015-12-07 )
MNKTIYDITIVGGGPVGLFAAFYAGLRGVSVKIIESLSELGGQPAILYPEKKIYDIPGYPVITGRELIDKHIEQLERFKDSIEICLKEEVLSFEKVDDVFTIQTDKDQHLSRAIVFACGNGAFAPRLLGLENEENYADNNLFYNVTKLEQFAGKHVVICGGGDSAVDWANELDKIAASVAIVHRRDAFRAHEHSVDILKASGVRILTPYVPIGLNGDSQRVSSLVVQKVKGDEVIELPLDNLIVSFGFSTSNKNLRYWNLDYKRSSINVSSLFETTQEGVYAIGDAANYPGKVELIATGYGEAPVAINQAINYIYPDRDNRVVHSTSLIK
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30.........40........50........60........---.70........80........90....-.----.---.----.100..-.-.-..-.110.......120....-..-.130.......140.-.....-.-150........160.......170.......180.......190---.----...-.-.-..200-.-........210.......220.......230........240.......250.....----..260-----..-..-...270----........280.......290.......300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MN
K
T
I
Y
D
I
T
I
VGGG
P
V
G
L
F
A
A
F
Y
AGLRG
V
S
-
V
K
I
I
E
S
L
S
E
LGGQ
P
A
I
LYPEK
K
I
YDIPG
Y
P
-VI
T
G
R
E
L
I
---
D
K
H
I
E
Q
L
E
R
F
K
D
S
I
E
I
C
L
K
E
E
V
L
S
F
EK-V----D---
D
----
V
F
T
I
QT-D-
K
-
D
Q
-
H
L
S
R
A
I
V
F
ACGNGAF
A
P
R
-LL-GLENEENYADN
N
L
F
Y
-
N
V
T
K
L
-
E
-
Q
F-AG
K
H
V
V
I
CGGGD
S
A
V
D
W
A
N
E
L
D
K
I
A
A
S
V
A
I
V
HRR
D
A
F
R
AH----E----H
S
V
-
D
-
I
-
L
KA---S-G
V
R
I
LTPY
V
P
IGLNG
D
S
Q
R
V
S
S
L
V
V
Q
KVK-GD
E
V
I
ELPLD
N
L
I
V
S
FGFSTSNK
N
L
R
Y
----
W
N
L
D
Y
-----KR-SS-I
N
V
S
S
-----
L
F
E
T
T
QE
G
V
Y
AIGDAANYPG
K
V
E
L
I
A
TGYGEA
P
V
A
I
N
Q
AI
N
Y
IYPDRDN
R
V
V
HSTSLIK
21
PsiBlast_CBE
92.64
52%
-120
- C1 -
3LZX
4
FENR2_BACSU
B:
[7-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
-
V
K
I
I
E
S
L
P
Q
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
I
R
A
Q
E
L
I
---
N
N
L
K
E
Q
M
A
K
F
D
Q
T
I
--
C
L
E
Q
A
V
E
S
V
E
K
Q
A
----
D
---
G
----
V
F
K
L
V
T
-
N
-
E
-
E
T
-
H
Y
S
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
-
K
L
-
E
L
E
N
A
E
Q
Y
E
G
K
N
L
H
Y
-
F
V
D
D
L
-
Q
-
K
F
-
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
I
A
K
E
V
S
I
I
H
R
R
D
K
F
R
A
H
----
E
----
H
S
V
-
E
-
N
-
L
H
A
---
S
-
K
V
N
V
L
T
P
F
V
P
A
E
L
I
G
E
D
-
K
I
E
Q
L
V
L
E
E
V
K
-
G
D
R
K
E
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
S
L
G
P
I
K
N
----
W
G
L
D
I
-----
E
K
-
N
S
-
I
V
V
K
S
-----
T
M
E
T
N
I
E
G
F
F
A
A
G
D
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
N
N
A
K
A
Y
M
D
P
K
A
R
V
Q
P
L
H
S
T
S
L
F
-
1
PsiBlast_PDB
92.17
52%
-116
- C1 -
3LZW
3
FENR2_BACSU
A:
[7-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
-
V
K
I
I
E
S
L
P
Q
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
I
R
A
Q
E
L
I
---
N
N
L
K
E
Q
M
A
K
F
D
Q
T
I
--
C
L
E
Q
A
V
E
S
V
E
K
Q
A
----
D
---
G
----
V
F
K
L
V
T
-
N
-
E
-
E
T
-
H
Y
S
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
-
K
L
-
E
L
E
N
A
E
Q
Y
E
G
K
N
L
H
Y
-
F
V
D
D
L
-
Q
-
K
F
-
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
I
A
K
E
V
S
I
I
H
R
R
D
K
F
R
A
H
----
E
----
H
S
V
-
E
-
N
-
L
H
A
---
S
-
K
V
N
V
L
T
P
F
V
P
A
E
L
I
G
E
D
-
K
I
E
Q
L
V
L
E
E
V
K
-
G
D
R
K
E
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
S
L
G
P
I
K
N
----
W
G
L
D
I
-----
E
K
-
N
S
-
I
V
V
K
S
-----
T
M
E
T
N
I
E
G
F
F
A
A
G
D
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
N
N
A
K
A
Y
M
D
P
K
A
R
V
Q
P
L
H
S
T
S
L
F
-
77
HHSearch
91.15
52%
-114
- C1 -
3LZW
3
FENR2_BACSU
A:
[4-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
K
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
-
V
K
I
I
E
S
L
P
Q
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
I
R
A
Q
E
L
I
---
N
N
L
K
E
Q
M
A
K
F
D
Q
T
--
I
C
L
E
Q
A
V
E
S
V
E
K
-
Q
----
A
D--
G
----
V
F
K
L
V
T
-
N
-
E
-
E
T
-
H
Y
S
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
-
K
L
-
E
L
E
N
A
E
Q
Y
E
G
K
N
L
H
Y
-
F
V
D
D
L
-
Q
-
K
F
-
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
I
A
K
E
V
S
I
I
H
R
R
D
K
F
R
A
H
----
E
----
H
S
V
-
E
-
N
-
L
H
A
---
S
-
K
V
N
V
L
T
P
F
V
P
A
E
L
I
G
E
-
D
K
I
E
Q
L
V
L
E
E
V
K
-
G
D
R
K
E
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
S
L
G
P
I
K
N
----
W
G
L
D
I
-----
E
K
-
N
S
-
I
V
V
K
S
-----
T
M
E
T
N
I
E
G
F
F
A
A
G
D
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
N
N
A
K
A
Y
M
D
P
K
A
R
V
Q
P
L
H
S
T
S
L
F
-
2
PsiBlast_PDB
91.10
52%
-118
- C1 -
3LZX
4
FENR2_BACSU
A:
[7-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
D
I
T
I
I
G
G
G
P
V
G
L
F
T
A
F
Y
G
G
M
R
Q
A
S
-
V
K
I
I
E
S
L
P
Q
L
G
G
Q
L
S
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
I
R
A
Q
E
L
I
---
N
N
L
K
E
Q
M
A
K
F
D
Q
T
I
--
C
L
E
Q
A
V
E
S
V
E
K
Q
A
----
D
---
G
----
V
F
K
L
V
T
-
N
-
E
-
E
T
-
H
Y
S
K
T
V
I
I
T
A
G
N
G
A
F
K
P
R
-
K
L
-
E
L
E
N
A
E
Q
Y
E
G
K
N
L
H
Y
-
F
V
D
D
L
-
Q
-
K
F
-
A
G
R
R
V
A
I
L
G
G
G
D
S
A
V
D
W
A
L
M
L
E
P
I
A
K
E
V
S
I
I
H
R
R
D
K
F
R
A
H
----
E
----
H
S
V
-
E
-
N
-
L
H
A
---
S
-
K
V
N
V
L
T
P
F
V
P
A
E
L
I
G
E
D
-
K
I
E
Q
L
V
L
E
E
V
K
-
G
D
R
K
E
I
L
E
I
D
D
L
I
V
N
Y
G
F
V
S
S
L
G
P
I
K
N
----
W
G
L
D
I
-----
E
K
-
N
S
-
I
V
V
K
S
-----
T
M
E
T
N
I
E
G
F
F
A
A
G
D
I
C
T
Y
E
G
K
V
N
L
I
A
S
G
F
G
E
A
P
T
A
V
N
N
A
K
A
Y
M
D
P
K
A
R
V
Q
P
L
H
S
T
S
L
F
-
3
PsiBlast_PDB
76.79
38%
-106
- C1 -
3AB1
1
FENR_CHLTE
A:
[14-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
D
L
T
I
I
G
G
G
P
T
G
I
F
A
A
F
Q
C
G
M
N
N
I
S
-
C
R
I
I
E
S
M
P
Q
L
G
G
Q
L
A
A
L
Y
P
E
K
H
I
Y
D
V
A
G
F
P
-
E
V
P
A
I
D
L
V
---
E
S
L
W
A
Q
A
E
R
Y
N
P
--
D
V
V
L
N
E
T
V
T
K
Y
T
K
-
L
----
D
---
D
G---
T
F
E
T
R
T
-
N
-
T
G
N
V
-
Y
R
S
R
A
V
L
I
A
A
G
L
G
A
F
E
P
R
-
K
L
P
Q
L
G
N
I
D
H
L
T
G
S
S
V
Y
Y
-
A
V
K
S
V
-
E
-
D
F
-
K
G
K
R
V
V
I
V
G
G
G
D
S
A
L
D
W
T
V
G
L
I
K
N
A
A
S
V
T
L
V
H
R
G
H
E
F
Q
G
H
G
K
T
-
A
----
H
E
V
-
E
-
R
-
A
R
A
---
N
-
G
T
I
D
V
Y
L
E
T
E
V
A
S
I
E
E
S
N
G
V
L
T
R
V
H
L
R
S
S
-
D
G
S
K
W
T
V
E
A
D
R
L
L
I
L
I
G
F
K
S
N
L
G
P
L
A
R
----
W
D
L
E
L
-----
Y
E
-
N
A
-
L
V
V
D
S
-----
H
M
K
T
S
V
D
G
L
Y
A
A
G
D
I
A
Y
Y
P
G
K
L
K
I
I
Q
T
G
L
S
E
A
T
M
A
V
R
H
S
L
S
Y
I
K
P
G
-------------
78
HHSearch
76.64
37%
-109
- C1 -
2ZBW
2
FENR_THET8
A:
[3-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
H
T
D
V
L
I
V
G
A
G
P
T
G
L
F
A
G
F
Y
V
G
M
R
G
L
S
-
F
R
F
V
D
P
L
P
E
P
G
G
Q
L
T
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
V
Y
A
K
D
L
V
---
K
G
L
V
E
Q
V
A
P
F
N
P
V
--
Y
S
L
G
E
R
A
E
T
L
E
R
-
E
----
G
---
D
----
L
F
K
V
T
T
-
S
Q
G
-
N
A
-
Y
T
A
K
A
V
I
I
A
A
G
V
G
A
F
E
P
R
-
R
I
-
G
A
P
G
E
R
E
F
E
G
R
G
V
Y
Y
-
A
V
K
S
K
-
A
-
E
F
-
Q
G
K
R
V
L
I
V
G
G
G
D
S
A
V
D
W
A
L
N
L
L
D
T
A
R
R
I
T
L
I
H
R
R
P
Q
F
R
A
H
----
E
A
S
V
K
E
L
M
-
K
-
A
-
H
E
E
---
G
-
R
L
E
V
L
T
P
Y
E
L
R
R
V
E
G
D
E
R
V
R
W
A
V
V
F
H
N
-
Q
-
T
Q
E
E
L
A
L
E
V
D
A
V
L
I
L
A
G
Y
I
T
K
L
G
P
L
A
N
----
W
G
L
A
L
-----
E
K
-
N
K
-
I
K
V
D
T
-----
T
M
A
T
S
I
P
G
V
Y
A
C
G
D
I
V
T
Y
P
G
K
L
P
L
I
V
L
G
F
G
E
A
A
I
A
A
N
H
A
A
A
Y
A
N
P
A
L
K
V
N
P
G
H
S
S
E
K
A
A
79
HHSearch
75.59
36%
-112
- C1 -
3AB1
1
FENR_CHLTE
A:
[13-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
R
D
L
T
I
I
G
G
G
P
T
G
I
F
A
A
F
Q
C
G
M
N
N
I
S
-
C
R
I
I
E
S
M
P
Q
L
G
G
Q
L
A
A
L
Y
P
E
K
H
I
Y
D
V
A
G
F
P
-
E
V
P
A
I
D
L
V
---
E
S
L
W
A
Q
A
E
R
Y
N
P
D
--
V
V
L
N
E
T
V
T
K
Y
T
K
-
L
----
D
D--
G
----
T
F
E
T
R
T
-
N
T
G
-
N
V
-
Y
R
S
R
A
V
L
I
A
A
G
L
G
A
F
E
P
R
K
L
P
-
Q
L
G
N
I
D
H
L
T
G
S
S
V
Y
Y
-
A
V
K
S
V
-
E
-
D
F
-
K
G
K
R
V
V
I
V
G
G
G
D
S
A
L
D
W
T
V
G
L
I
K
N
A
A
S
V
T
L
V
H
R
G
H
E
F
Q
G
H
G
K
T
A
H
----
E
V
E
-
R
-
A
-
R
A
N
---
G
-
T
I
D
V
Y
L
E
T
E
V
A
S
I
E
E
S
N
G
V
L
T
R
V
H
L
R
S
-
S
-
D
G
S
K
W
T
V
E
A
D
R
L
L
I
L
I
G
F
K
S
N
L
G
P
L
A
R
----
W
D
L
E
L
-----
Y
E
-
N
A
-
L
V
V
D
S
-----
H
M
K
T
S
V
D
G
L
Y
A
A
G
D
I
A
Y
Y
P
G
K
L
K
I
I
Q
T
G
L
S
E
A
T
M
A
V
R
H
S
L
S
Y
I
K
P
G
-------------
22
PsiBlast_CBE
75.08
38%
-102
- C1 -
3AB1
2
FENR_CHLTE
B:
[14-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
D
L
T
I
I
G
G
G
P
T
G
I
F
A
A
F
Q
C
G
M
N
N
I
S
-
C
R
I
I
E
S
M
P
Q
L
G
G
Q
L
A
A
L
Y
P
E
K
H
I
Y
D
V
A
G
F
P
-
E
V
P
A
I
D
L
V
---
E
S
L
W
A
Q
A
E
R
Y
N
P
--
D
V
V
L
N
E
T
V
T
K
Y
T
K
-
L
----
D
---
D
G---
T
F
E
T
R
T
-
N
-
T
G
N
V
-
Y
R
S
R
A
V
L
I
A
A
G
L
G
A
F
E
P
R
-
K
L
P
Q
L
G
N
I
D
H
L
T
G
S
S
V
Y
Y
-
A
V
K
S
V
-
E
-
D
F
-
K
G
K
R
V
V
I
V
G
G
G
D
S
A
L
D
W
T
V
G
L
I
K
N
A
A
S
V
T
L
V
H
R
G
H
E
F
Q
G
H
GKT-
A
----
H
E
V
-
E
-
R
-
A
R
A
---
N
-
G
T
I
D
V
Y
L
E
T
E
V
A
S
I
E
E
S
N
G
V
L
T
R
V
H
L
R
S
S
-
D
G
S
K
W
T
V
E
A
D
R
L
L
I
L
I
G
F
K
S
N
L
G
P
L
A
R
----
W
D
L
E
L
-----
Y
E
-
N
A
-
L
V
V
D
S
-----
H
M
K
T
S
V
D
G
L
Y
A
A
G
D
I
A
Y
Y
P
G
K
L
K
I
I
Q
T
G
L
S
E
A
T
M
A
V
R
H
S
L
S
Y
I
K
P
G
E
K
I
R
N
V
F
S
S
V
K
M
A
4
PsiBlast_PDB
72.15
39%
-108
- C1 -
2ZBW
1
FENR_THET8
A:
[7-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
I
V
G
A
G
P
T
G
L
F
A
G
F
Y
V
G
M
R
G
L
S
-
F
R
F
V
D
P
L
P
E
P
G
G
Q
L
T
A
L
Y
P
E
K
Y
I
Y
D
V
A
G
F
P
-
K
V
Y
A
K
D
L
V
---
K
G
L
V
E
Q
V
A
P
F
N
P
V
Y
S
L
G
E
R
A
E
T
L
--
E
R
-
E
----
G
---
D
----
L
F
K
V
T
T
-
S
-
Q
G
N
A
-
Y
T
A
K
A
V
I
I
A
A
G
V
G
A
F
E
P
R
-
R
I
-
G
A
P
G
E
R
E
F
E
G
R
G
V
Y
Y
-
A
V
K
S
K
-
A
-
E
F
-
Q
G
K
R
V
L
I
V
G
G
G
D
S
A
V
D
W
A
L
N
L
L
D
T
A
R
R
I
T
L
I
H
R
R
P
Q
F
R
A
H
----
E
----
A
S
V
K
E
-
L
-
M
K
A
H
E
E
G
-
R
L
E
V
L
T
P
Y
E
L
R
R
V
E
G
D
-
E
R
V
R
W
A
V
V
F
H
N
Q
-
T
Q
E
E
L
A
L
E
V
D
A
V
L
I
L
A
G
Y
I
T
K
L
G
P
L
A
N
----
W
G
L
A
L
-----
E
K
-
N
K
-
I
K
V
D
T
-----
T
M
A
T
S
I
P
G
V
Y
A
C
G
D
I
V
T
Y
P
G
K
L
P
L
I
V
L
G
F
G
E
A
A
I
A
A
N
H
A
A
A
Y
A
N
P
A
L
K
V
N
P
G
H
S
S
E
K
A
A
68
Fugue
69.57
22%
-112
- C1 -
1HYU
4
AHPF_SALTY
A:
[1-521]
MLD
T
N
M
K
T
Q
L
R
A
Y
L
E
KLT
K
P
V
E
L
I
A
T
L
D
DS
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
DK
V
T
F
K
E
D
NTLPVRKP
S
F
L
I
T
N
PGSQ
Q
G
P
R
F
A
G
SPLGHE
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
KEA
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
LSCHN
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
NPR
I
K
H
T
A
I
D
GGTF
Q
N
E
I
T
E
R
NVMGVP
A
V
F
V
NGKEFGQGRMT
L
T
E
I
V
A
K
V
D
TGAEK
R
A
A
E
A
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
-
T
G
L
M
G
E
--
R
F
G
G
---
Q
V
L
D
T
V
D
I
E
N
Y
I
S
V
P
-
K
T
E
G
Q
K
L
A
---
G
A
L
K
A
H
V
S
D
Y
--
D
V
D
V
I
D
S
Q
S
A
S
K
L
V
P
-
A
----
A
TEG
G
----
L
H
Q
I
E
T
A
S
-
G
-
A
V
-
L
K
A
R
S
I
I
I
A
T
G
---
A
K
W
R
-
N
M
-
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
-
P
-
L
F
-
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
----
Q
----
V
L
Q
-
D
-
K
-
V
R
S
---
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
-
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
H
W
L
E
G
----
A
L
E
R
N
-----
R
M
-
G
E
-
I
I
I
D
A
-----
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
T
V
P
Y
K
Q
--
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
I
A
----------
82
HHSearch
69.27
24%
-110
- C1 -
1FL2
5
AHPF_ECOLI
A:
[1-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
-
T
G
L
M
G
E
--
R
F
G
G
Q
I
L
D
T
V
D
---
I
E
N
Y
I
S
V
P
-
K
T
E
G
Q
K
L
A
---
G
A
L
K
V
H
V
D
E
Y
D
V
D
--
V
I
D
S
Q
S
A
S
K
L
I
P
-
A
AVE-
G
---
G
----
L
H
Q
I
E
T
-
A
S
G
-
A
V
-
L
K
A
R
S
I
I
V
A
T
G
A
---
K
W
R
-
N
M
-
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
-
C
P
H
C
D
G
P
-
L
F
-
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
----
Q
----
V
L
Q
-
D
-
K
-
L
R
S
L--
K
-
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
-
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
----
A
-
V
E
R
-----
N
R
M
G
E
-
I
I
I
D
A
-----
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
P
Y
K
--
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
T
A
----------
81
HHSearch
67.89
27%
-112
- C1 -
3R9U
2
?
A:
[1-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
A
M
L
D
V
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
L
K
N
V
V
M
F
E
K
G
M
-
P
G
G
Q
I
T
S
S
S
---
E
I
E
N
Y
P
G
V
A
Q
V
M
D
G
I
S
F
M
---
A
P
W
S
E
Q
C
M
R
F
G
L
K
--
H
-
E
M
V
G
V
E
Q
I
L
K
-
N
S---
D
---
G
----
S
F
T
I
K
L
-
E
G
G
-
K
T
-
E
L
A
K
A
V
I
V
C
T
G
S
---
A
P
K
-
K
A
-
G
F
K
G
E
D
E
F
F
G
K
G
V
S
T
-
C
A
T
C
D
-
G
F
F
Y
-
K
N
K
E
V
A
V
L
G
G
G
D
T
A
L
E
E
A
L
Y
L
A
N
I
C
S
K
I
Y
L
I
H
R
R
D
E
F
R
A
A
----
P
----
S
T
V
-
E
-
K
V
K
K
N
---
E
-
K
I
E
L
I
T
S
A
S
V
D
E
V
Y
G
D
K
M
G
V
A
G
V
K
V
K
L
-
K
-
D
G
S
I
R
D
L
N
V
P
G
I
F
T
F
V
G
L
N
V
R
N
E
I
L
K
Q
DDSK
F
L
C
N
M
-----
E
E
G
G
Q
-
V
S
V
D
L
-----
K
M
Q
T
S
V
A
G
L
F
A
A
G
D
L
R
K
D
A
--
P
K
Q
V
I
C
A
A
G
D
G
A
V
A
A
L
S
A
M
A
Y
I
E
S
L
-------------
88
HHSearch
67.42
23%
-111
- C1 -
1HYU
4
AHPF_SALTY
A:
[209-518]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
-
T
G
L
M
G
E
R
--
F
G
G
Q
V
L
D
T
V
D
---
I
E
N
Y
I
S
V
P
-
K
T
E
G
Q
K
L
A
---
G
A
L
K
A
H
V
S
D
Y
D
V
D
--
V
I
D
S
Q
S
A
S
K
L
V
P
-
A
----
A
TEG
G
----
L
H
Q
I
E
T
-
A
S
G
-
A
V
-
L
K
A
R
S
I
I
I
A
T
G
A
---
K
W
R
-
N
M
-
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
-
C
P
H
C
D
-
G
P
L
F
-
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
----
Q
----
V
L
Q
-
D
-
K
-
V
R
S
L--
K
-
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
-
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
H
W
L
E
G
-----
A
L
E
R
-----
N
R
M
G
E
-
I
I
I
D
A
-----
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
T
V
P
Y
--
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
I
A
----------
92
HHSearch
66.53
26%
-97
- C1 -
1TRB
1
TRXB_ECOLI
A:
[2-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
K
H
S
K
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
-
P
V
L
I
T
G
M
E
-
K
G
G
Q
L
T
T
T
T
E
---
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
---
E
R
M
H
E
H
A
T
K
F
E
T
E
--
I
-
I
F
D
H
I
N
K
V
D
L
-
Q
----
N
---
R
----
P
F
R
L
N
G
-
D
-
N
-
G
E
-
Y
T
C
D
A
L
I
I
A
T
G
A
---
S
A
R
-
Y
L
-
G
L
P
S
E
E
A
F
K
G
R
G
V
S
A
-
C
A
T
S
D
-
G
F
F
Y
-
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
L
I
K
----
R
L
M
-
D
-
K
-
V
E
N
---
G
-
N
I
I
L
H
T
N
R
T
L
E
E
V
T
G
D
Q
M
G
V
T
G
V
R
L
R
D
T
Q
N
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
G
-----
Q
L
E
L
-----
E
N
-
G
Y
-
I
K
V
Q
S
GIHGN
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
Y
R
--
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
G
L
-------------
80
HHSearch
66.46
25%
-116
- C1 -
3F8D
3
?
A:
[12-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
-
T
L
V
I
G
E
T
--
P
G
G
Q
L
T
E
A
G
I
---
V
D
D
Y
L
G
L
I
-
E
I
Q
A
S
D
M
I
---
K
V
F
N
K
H
I
E
K
Y
E
V
P
--
V
L
-
L
D
I
V
E
K
I
E
N
-
R
-------------
E
F
V
V
K
T
-
K
R
K
-
G
E
-
F
K
A
D
S
V
I
L
G
I
G
V
---
K
R
R
-
K
L
-
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
-
C
S
V
A
D
A
P
-
L
F
-
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
----
P
----
I
Y
V
-
E
-
T
V
K
K
K
---
P
-
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
K
-
V
V
K
Q
V
V
V
E
N
L
K
-
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
----
N
G
I
E
T
-----
D
T
N
G
Y
-
I
K
V
D
E
-----
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
-------------
87
HHSearch
66.44
28%
-106
- C1 -
2Q7V
2
?
A:
[5-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
H
D
Y
D
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
S
-
T
L
I
L
E
K
G
M
-
P
G
G
Q
I
A
W
S
E
--
E
-
V
E
N
F
P
G
F
P
E
P
I
A
G
M
E
L
A
---
Q
R
M
H
Q
Q
A
E
K
F
G
A
K
--
V
E
M
-
D
E
V
Q
G
V
Q
H
-
D
----
A
---
T
SHPY
P
F
T
V
R
G
-
Y
-
N
-
G
E
-
Y
R
A
K
A
V
I
L
A
T
G
A
---
D
P
R
-
K
L
-
G
I
P
G
E
D
N
F
W
G
K
G
V
S
T
-
C
A
T
C
D
-
G
F
F
Y
-
K
G
K
K
V
V
V
I
G
G
G
D
A
A
V
E
E
G
M
F
L
T
K
F
A
D
E
V
T
V
I
H
R
R
D
T
L
R
A
N
----
K
V
---
A
Q
A
-
R
-
A
-
F
A
N
---
P
-
K
M
K
F
I
W
D
T
A
V
E
E
I
Q
G
A
D
-
S
V
S
G
V
K
L
R
N
L
K
-
T
G
E
V
S
E
L
A
T
D
G
V
F
I
F
I
G
H
V
P
N
T
A
F
V
K
D
-----
T
V
S
L
-----
R
D
D
G
Y
-
V
D
V
R
D
-----
E
I
Y
T
N
I
P
M
L
F
A
A
G
D
V
S
D
Y
I
Y
R
Q
--
L
A
T
S
V
G
A
G
T
R
A
A
M
M
T
E
R
Q
L
A
A
L
-------------
10
PsiBlast_PDB
65.45
26%
-107
- C1 -
3R9U
2
?
A:
[6-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
L
K
-
N
V
V
M
F
E
K
G
M
P
G
G
Q
---
I
T
S
S
S
E
I
E
N
Y
P
G
V
A
Q
V
M
D
G
I
S
F
M
---
A
P
W
S
E
Q
C
M
R
F
G
------
L
K
H
E
M
V
G
V
E
Q
-
I
L
K
N
S
D
---
G
----
S
F
T
I
K
L
-
E
-
G
-
G
K
T
E
L
A
K
A
V
I
V
C
T
G
S
---
A
P
K
-
K
A
-
G
F
K
G
E
D
E
F
F
G
K
G
V
S
T
-
C
A
T
C
D
-
G
-
F
F
Y
K
N
K
E
V
A
V
L
G
G
G
D
T
A
L
E
E
A
L
Y
L
A
N
I
C
S
K
I
Y
L
I
H
R
R
D
E
F
R
A
A
----
P
----
S
T
V
-
E
K
V
-
K
K
N
---
E
-
K
I
E
L
I
T
S
A
S
V
D
E
V
Y
G
D
K
M
G
V
A
G
V
K
V
-
K
L
K
-
D
G
S
I
R
D
L
N
V
P
G
I
F
T
F
V
G
L
N
V
R
N
E
I
L
K
Q
----
D
D
S
K
F
LCNME
E
G
-
G
Q
-
V
S
V
D
L
-----
K
M
Q
T
S
V
A
G
L
F
A
A
G
D
L
R
K
D
A
P
K
Q
V
I
C
A
A
G
D
G
--
A
V
A
A
L
S
A
M
A
Y
I
E
S
L
-------------
13
PsiBlast_PDB
64.32
25%
-117
- C1 -
3F8R
3
?
A:
[16-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
-
T
L
V
I
G
E
T
P
--
G
G
Q
---
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
-
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-----
V
P
V
L
L
-
D
I
V
E
K
I
E
N
-
R
-------------
E
F
V
V
K
T
-
K
R
K
-
G
E
-
F
K
A
D
S
V
I
L
G
I
G
---
V
K
R
R
-
K
L
-
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
-
P
-
L
F
-
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
----
P
----
I
Y
V
-
E
-
T
-
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
-
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
----
N
G
I
E
T
-----
D
T
-
N
G
Y
I
K
V
D
E
-----
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
-------------
12
PsiBlast_PDB
64.10
25%
-117
- C1 -
3F8P
4
?
A:
[16-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
-
T
L
V
I
G
E
T
P
--
G
G
Q
---
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
-
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-----
V
P
V
L
L
-
D
I
V
E
K
I
E
N
---------------
E
F
V
V
K
T
-
K
R
K
-
G
E
-
F
K
A
D
S
V
I
L
G
I
G
---
V
K
R
R
-
K
L
-
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
-
P
-
L
F
-
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
----
P
----
I
Y
V
-
E
-
T
-
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
-
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
----
N
G
I
E
T
-----
D
T
-
N
G
Y
I
K
V
D
E
-----
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
-------------
11
PsiBlast_PDB
63.99
25%
-116
- C1 -
3F8D
3
?
A:
[16-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
-
T
L
V
I
G
E
T
P
--
G
G
Q
---
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
-
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
-----
V
P
V
L
L
-
D
I
V
E
K
I
E
N
-
R
-------------
E
F
V
V
K
T
-
K
R
K
-
G
E
-
F
K
A
D
S
V
I
L
G
I
G
---
V
K
R
R
-
K
L
-
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
-
P
-
L
F
-
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
----
P
----
I
Y
V
-
E
-
T
-
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
-
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
----
N
G
I
E
T
-----
D
T
-
N
G
Y
I
K
V
D
E
-----
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
-------------