@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1443: (2015-12-08 )
MIYFDNSATTIPYPEVLRTYQEVASKIYGNPSSLHELGTTSSRILEASRKQIASLLELKANEIFFTSGGTEADNWVIKGLAFEKQHFGNHIIVSDIEHPAIKESAKWLGEYGFEIDYAPVDDKGFVDVEALVKLIKPETILISIMAINNEIGSIQPIKAISDLLSDKPTISFHIDAVQAIGKIPTKDYLTERVDFASFSSHKFHGVRGVGFLYIKEGKRISPLLTGGGQESDLRSTTENVAGIAATAKALRMVMDKEVVAIPKISKMKTIIHDELAKYEDITLFSGKEDFSPNIITFGIKGVRGEVLVHAFEGHDIFISTTSACSSKAGKPAGTLIAMGISTKLAQTAVRISLDDDNDMGQVEQFLTIFKQVYEKTKKVRG
Atome Classification :
(26 SA)
-.........10........20.....--.-------..30...-.....40........50.......----.60........70........80-.-------...-------....-.------90--.-........100.......110-..-......------120-.......130.....--..140-.........150.......160..---------...---------..170-.......180.......190.......200.......210...-------...--.-------220.---..---....230.......240.......250....-...260.......270...------....280....----...---290-........300-..--......310.......320..-.....-330.......340.......350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
I
YFDNSATTIP
Y
P
E
V
L
R
T
Y
Q
E
V
A
S
K
--I-------YG
N
P
S
S
L
-
H
E
LGT
T
S
S
R
I
L
E
A
S
R
K
Q
I
A
S
L
L
E
L----KAN
E
I
F
F
TSGGTEAD
N
W
V
I
KG
L
--
A
-------
F
E
K
-------
Q
HFG-
N
------
H
---
I
-
I
V
SDIEH
P
A
I
K
E
S
A
K
W
L
G
E-Y-GF-
E
I
DYAP------VDD-KGFV
D
V
E
A
L
V
K
LIKP--
E
T
I
---
L
I
S
I
M
A
INNEIGSIQ
P
I
K
A
I
S
D
L
L---------SDK---------P
T
I
S
F
-
H
I
D
A
V
Q
A
I
GKIP
T
K
D
Y
L
T
E
RVDFASFSSHKFHG
V
R
G
V
G
F
L
Y
IK-------EG
K
--
R
-------
I
S
P
L
---LT---GGGQE
S
D
L
R
S
T
T
E
N
V
A
G
I
A
A
T
A
K
A
L
R
M
V
MDK-EVVAIP
K
I
S
K
M
K
T
I
I
H
D
E
L
------AKYE
D
I
T
L
FSG----KED---FS--P
N
I
I
T
F
GIKG--VR--
G
E
V
L
V
H
A
FEG
H
D
I
F
I
STTSAC-SSKAG-KPA
G
T
L
I
A
MGIS
T
K
L
A
Q
T
A
V
R
I
S
LDDDN
D
M
G
Q
V
E
Q
F
L
T
I
F
K
Q
V
Y
E
K
T
K
KVRG-
53
Fugue
93.70
38%
-91
* C1 *
1ECX
2
?
A:
[1-376]
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
--
K
-------
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
----
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
--
A
-------
E
T
F
-------
E
K
R
K
-
R
------
T
---
I
-
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
-
K
-
G
F
-
K
V
K
Y
V
P
------
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
E
--
D
T
F
---
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
K
N--------
K
E
T
L
V
-
H
V
D
A
V
Q
T
I
G
K
I
P
F
-
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
-------
K
G
V
--
P
-------
I
R
P
L
---
I
H
---
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
-
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
------
M
N
-
L
G
A
H
I
I
T
P
----
L
E
I
---
S
L
--
P
N
T
L
S
V
S
F
P
N
--
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
2
PsiBlast_PDB
92.57
39%
-91
- C1 -
1EG5
3
?
A:
[3-372]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
--
K
-------
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
----
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
--
A
E
T
-----
F
E
K
-------
R
K
---
R
------
T
---
I
-
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
-
K
-
G
F
-
K
V
K
Y
V
P
------
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
E
--
D
T
F
---
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
K
---------
N
K
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
-
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
-------
K
G
V
--
P
-------
I
R
P
L
---
I
H
---
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
-
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
------
M
N
L
-
G
A
H
I
I
T
P
----
L
E
I
---
S
L
--
P
N
T
L
S
V
S
F
P
N
--
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
1
PsiBlast_PDB
92.29
39%
-92
- C1 -
1ECX
2
?
A:
[3-372]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
--
K
-------
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
----
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
--
A
E
T
-----
F
E
K
-------
R
K
---
R
------
T
---
I
-
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
-
K
-
G
F
-
K
V
K
Y
V
P
------
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
E
--
D
T
F
---
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
K
---------
N
K
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
-
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
-------
K
G
V
--
P
-------
I
R
P
L
---
I
H
---
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
-
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
------
M
N
L
-
G
A
H
I
I
T
P
----
L
E
I
---
S
L
--
P
N
T
L
S
V
S
F
P
N
--
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
30
HHSearch
92.00
39%
-86
- C1 -
1EG5
3
?
A:
[2-376]
-
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
--
K
-------
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
----
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
--
A
-------
E
T
F
--------
E
K
R
-
K
------
R
---
T
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
-
K
-
G
F
-
K
V
K
Y
V
P
------
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
E
--
D
T
F
---
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
K
N--------
K
E
T
L
V
-
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
-
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
-------
K
G
V
--
P
-------
I
R
P
L
---
I
H
---
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
-
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
------
M
N
L
-
G
A
H
I
I
T
P
----
L
E
I
---
S
L
--
P
N
T
L
S
V
S
F
P
N
--
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
21
PsiBlast_CBE
91.67
39%
-91
- C1 -
1ECX
2
?
B:
[3-372]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
--
K
-------
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
----
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
--
A
ET-----
F
E
K
-------
R
K
---
R
------
T
---
I
-
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
-
K
-
G
F
-
K
V
K
Y
V
P
------
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
E
--
D
T
F
---
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
K
---------
N
K
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
-
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
-------
K
G
V
--
P
-------
I
R
P
L
---
I
H
---
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
-
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
------
M
N
L
-
G
A
H
I
I
T
P
----
L
E
I
---
S
L
--
P
N
T
L
S
V
S
F
P
N
--
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
-------------
R
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
6
PsiBlast_PDB
88.36
32%
-84
- C1 -
4EB7
7
ISCS2_ARCFU
A:
[2-376]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
--
S
-------
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
----
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
--
A
-------
M
R
N
-------
A
R
K
G
-
K
------
H
---
I
-
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
-
Q
-
G
F
-
E
V
E
Y
I
P
------
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
D
--
D
T
I
---
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
G
K
---------
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
-
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
-------
K
E
A
--
K
-------
L
Q
P
V
---
I
L
---
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
------
L
K
I
E
E
S
Y
L
N
G
H
----
P
E
K
---
R
L
--
P
N
N
V
N
V
R
F
S
Y
--
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
-
T
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
-
5
PsiBlast_PDB
88.19
32%
-84
- C1 -
4EB5
6
ISCS2_ARCFU
A:
[2-376]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
--
S
-------
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
----
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
--
A
-------
M
R
N
-------
A
R
K
G
-
K
------
H
---
I
-
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
-
Q
-
G
F
-
E
V
E
Y
I
P
------
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
D
--
D
T
I
---
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
G
K
---------
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
-
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
-------
K
E
A
--
K
-------
L
Q
P
V
---
I
L
---
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
------
L
K
I
E
E
S
Y
L
N
G
H
----
P
E
K
---
R
L
--
P
N
N
V
N
V
R
F
S
Y
--
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
-
7
PsiBlast_PDB
88.09
32%
-88
- C1 -
4HVK
12
ISCS2_ARCFU
A:
[2-376]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
--
S
-------
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
----
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
--
A
-------
M
R
N
-------
A
R
K
G
-
K
------
H
---
I
-
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
-
Q
-
G
F
-
E
V
E
Y
I
P
------
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
D
--
D
T
I
---
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
G
K
---------
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
-
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
-------
K
E
A
--
K
-------
L
Q
P
V
---
I
L
---
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
------
L
K
I
E
E
S
Y
L
N
G
H
----
P
E
K
---
R
L
--
P
N
N
V
N
V
R
F
S
Y
--
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
----------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
-
24
PsiBlast_CBE
87.93
32%
-88
- C1 -
4EB5
5
ISCS2_ARCFU
B:
[2-376]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
--
S
-------
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
----
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
--
A
-------
M
R
N
-------
A
R
K
G
-
K
------
H
---
I
-
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
-
Q
-
G
F
-
E
V
E
Y
I
P
------
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
D
--
D
T
I
---
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
G
K
---------
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
-
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
-------
K
E
A
--
K
-------
L
Q
P
V
---
I
L
---
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
------
L
K
I
E
E
S
Y
L
N
G
H
----
P
E
K
---
R
L
--
P
N
N
V
N
V
R
F
S
Y
--
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
-
23
PsiBlast_CBE
86.82
32%
-85
- C1 -
4EB7
4
ISCS2_ARCFU
B:
[2-376]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
--
S
-------
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
----
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
--
A
-------
M
R
N
-------
A
R
K
G
-
K
------
H
---
I
-
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
-
Q
-
G
F
-
E
V
E
Y
I
P
------
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
D
--
D
T
I
---
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
G
K
---------
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
-
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
-------
K
E
A
--
K
-------
L
Q
P
V
---
I
L
---
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
------
L
K
I
E
E
S
Y
L
N
G
H
----
P
E
K
---
R
L
--
P
N
N
V
N
V
R
F
S
Y
--
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
-
54
Fugue
83.76
30%
-78
- C1 -
4ISY
3
ISCSL_MYCTU
A:
[12-398]
-
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
T
--
I
--------
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
----
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
--
Y
-------
W
A
R
-------
R
D
A
E
-
P
------
H
RR
R
I
-
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
-
H
E
G
A
-
H
V
T
W
L
P
------
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
---
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
---------
M
E
F
---------
G
-
V
P
M
-
H
S
D
A
I
Q
A
V
G
Q
L
P
L
-
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
-------
R
D
V
--
T
-------
C
V
P
L
---
M
H
---
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
-
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
G
V
------
L
A
E
I
D
D
V
C
L
N
G
----
A
D
D
---
P
M
RL
A
G
N
A
H
F
T
F
R
G
--
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
---------
G
-
S
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
A
22
PsiBlast_CBE
83.33
35%
-85
- C1 -
3LVJ
2
ISCS_ECO57
B:
[24-376]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
M
DG
T
-------
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
----
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
--
A
-------
N
F
Y
-------
Q
K
K
G
-
K
------
H
---
I
-
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
E
R
-
E
-
G
F
-
E
V
T
Y
L
A
------
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
D
--
D
T
I
---
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
---------
R
A
R
---------
G
I
I
-
Y
-
H
V
D
A
T
Q
S
V
G
K
L
P
I
-
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
-------
R
K
P
RV
R
-------
I
E
A
Q
---
M
H
---
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
-
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
N
G
I
------
K
D
I
E
E
V
Y
L
N
G
D
----
L
E
H
---
G
A
--
P
N
I
L
N
V
S
F
N
Y
--
V
E
--
G
E
S
L
I
M
A
L
K
--
D
L
A
V
S
S
G
S
A
C
-----
L
-
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
D
L
S
P
-
3
PsiBlast_PDB
83.15
35%
-86
- C1 -
3LVJ
2
ISCS_ECO57
A:
[24-376]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
M
DG
T
-------
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
----
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
--
A
-------
N
F
Y
-------
Q
K
K
G
-
K
------
H
---
I
-
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
E
R
-
E
-
G
F
-
E
V
T
Y
L
A
------
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
D
--
D
T
I
---
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
---------
R
A
R
---------
G
I
I
-
Y
-
H
V
D
A
T
Q
S
V
G
K
L
P
I
-
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
-------
R
K
P
R
V
R
-------
I
E
A
Q
---
M
H
---
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
-
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
N
G
I
------
K
D
I
E
E
V
Y
L
N
G
D
----
L
E
H
---
G
A
--
P
N
I
L
N
V
S
F
N
Y
--
V
E
--
G
E
S
L
I
M
A
L
K
--
D
L
A
V
S
S
G
-------
S
L
-
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
D
L
S
P
-
4
PsiBlast_PDB
81.61
35%
-85
- C1 -
3LVK
1
ISCS_ECO57
A:
[24-376]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
M
DG
T
-------
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
----
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
--
A
-------
N
F
Y
-------
Q
K
K
G
-
K
------
H
---
I
-
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
E
R
-
E
-
G
F
-
E
V
T
Y
L
A
------
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
D
--
D
T
I
---
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
---------
R
A
R
---------
G
I
I
-
Y
-
H
V
D
A
T
Q
S
V
G
K
L
P
I
-
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
-------
R
K
P
R
V
R
-------
I
E
A
Q
---
M
H
---
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
-
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
N
G
I
------
K
D
I
E
E
V
Y
L
N
G
D
----
L
E
H
---
G
A
--
P
N
I
L
N
V
S
F
N
Y
--
V
E
--
G
E
S
L
I
M
A
L
K
--
D
L
A
V
S
S
G
S
A
C
-----
L
-
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
D
L
S
P
-
14
PsiBlast_PDB
80.98
29%
-79
- C1 -
3GZD
3
SCLY_HUMAN
C:
[27-431]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
M
T
K
A
M
W
E
--
A
-------
W
G
N
P
S
S
P
-
Y
S
A
G
R
K
A
K
D
I
I
N
A
A
R
E
S
L
A
K
M
I
G
G
----
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
V
--
V
KHFHANQ
T
S
--------------GAKP--
H
---
F
-
I
T
S
S
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
-
E
-
Q
V
A
A
V
T
F
V
P
------
V
S
K
V
S
G
Q
T
E
V
D
D
I
L
A
A
V
R
P
--
T
T
R
---
L
V
T
I
M
L
A
N
N
E
T
G
I
V
M
P
V
P
E
I
S
Q
R
I
KALNQERVA
A
G
L
---------
P
P
I
L
V
-
H
T
D
A
A
Q
A
L
G
K
Q
-
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
I
R
GLG----
E
F
T
--
P
-------
L
Y
P
M
---
L
F
---
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
E
L
V
T
Q
N
-
C
E
A
Y
E
A
H
M
R
D
V
R
D
Y
L
E
E
R
L
EAEFGQ
K
R
I
H
L
N
S
Q
F
P
G
----
T
Q
R
---
L
---
P
N
T
C
N
F
S
I
R
G
--
P
R
--
L
Q
G
H
V
V
L
A
Q
C
R
V
L
M
A
S
V
G
A
A
C
------D
Q
P
S
P
V
L
L
S
Y
G
V
P
F
D
V
A
R
N
A
L
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
V
V
Q
D
L
K
Q
A
V
A
Q
L
E
D
----
8
PsiBlast_PDB
80.77
31%
-77
- C1 -
4ISY
3
ISCSL_MYCTU
A:
[14-385]
---
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
T
--
I
--------
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
----
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
--
Y
-------
W
A
R
-------
R
D
A
E
-
P
------
H
RR
R
I
-
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
-
H
E
G
A
-
H
V
T
W
L
P
------
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
---
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
-
V
V
---------
A
M
E
---------
F
G
V
P
M
-
H
S
D
A
I
Q
A
V
G
Q
L
P
L
-
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
-------
R
D
V
--
T
-------
C
V
P
L
---
M
H
---
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
G
V
L
------
A
E
I
D
D
V
C
L
-
N
G
----
A
D
D
PMR
L
A
--
G
N
-
A
H
F
T
F
R
G
--
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
-
12
PsiBlast_PDB
80.55
32%
-87
- C1 -
4IXO
2
?
A:
[9-376]
-
M
I
Y
L
D
H
N
A
T
T
F
I
D
P
R
V
K
E
F
I
I
S
L
M
D
K
--
E
-------
L
-
N
P
S
S
A
-
H
S
S
G
R
F
A
K
N
L
I
E
T
V
R
A
Q
I
A
T
A
L
G
I
TLSS
R
E
Y
D
I
T
F
T
S
S
G
T
E
G
N
N
L
I
M
K
N
F
----------------------
Y
D
-
G
------
D
---
I
-
F
I
S
A
I
E
H
L
S
I
Y
N
-------------
H
I
N
Y
A
P
N
I
K
V
I
S
V
N
T
-
Q
G
L
V
D
L
E
H
L
E
E
L
L
A
Q
--
S
N
T
S
K
K
L
V
S
I
I
M
A
N
N
E
S
G
V
L
Q
D
I
A
E
I
G
K
I
----------
T
K
K
---------
Y
E
A
K
F
-
H
S
D
L
V
Q
G
F
G
R
I
P
I
-
N
I
K
A
L
G
L
D
F
A
T
I
S
G
H
K
I
G
G
G
Q
G
G
A
A
L
I
S
S
-------
S
N
F
--
Q
-------
I
T
P
M
---
I
I
---
G
G
G
Q
E
K
S
V
R
S
G
T
E
N
V
L
A
I
A
G
F
G
L
A
S
A
L
R
T
D
N
-
I
S
E
N
Y
I
K
I
K
K
L
Q
E
N
L
E
K
K
L
------
K
K
Y
P
N
V
N
I
V
S
N
----
N
V
A
---
R
L
--
P
N
T
T
L
I
T
I
P
N
--
T
D
--
A
Q
A
K
L
I
G
F
D
L
H
N
I
C
V
S
S
G
------------
S
H
V
L
T
N
M
G
V
G
E
E
E
A
K
S
S
I
R
I
S
L
S
H
T
N
T
V
R
D
I
E
A
F
I
E
A
F
E
E
I
Y
D
V
-------
25
PsiBlast_CBE
80.32
31%
-76
- C1 -
4ISY
1
ISCSL_MYCTU
D:
[14-385]
---
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
T
--
I
--------
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
----
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
--
Y
-------
W
A
R
-------
R
D
A
E
-
P
------
H
RRR
I
-
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
-
H
E
G
A
-
H
V
T
W
L
P
------
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
HD
D
V
A
---
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
-
V
V
---------
A
M
E
---------
F
G
V
P
M
-
H
S
D
A
I
Q
A
V
G
Q
L
P
L
-
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
-------
R
D
V
--
T
-------
C
V
P
L
---
M
H
---
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
G
V
L
------
A
E
I
D
D
V
C
L
-
N
G
----
A
D
D
PMR
L
A
--
G
N
-
A
H
F
T
F
R
G
--
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
-
13
PsiBlast_PDB
80.07
29%
-78
- C1 -
3GZC
2
SCLY_HUMAN
A:
[27-431]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
M
T
K
A
M
W
E
--
A
-------
W
G
N
P
S
S
P
-
Y
S
A
G
R
K
A
K
D
I
I
N
A
A
R
E
S
L
A
K
M
I
G
G
----
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
V
--
V
K
H
F
H
A
N
Q
T
---------------G
A
K
P
--
H
---
F
-
I
T
S
S
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
-
E
-
Q
V
A
A
V
T
F
V
P
------
V
S
K
V
S
G
Q
T
E
V
D
D
I
L
A
A
V
R
P
--
T
T
R
---
L
V
T
I
M
L
A
N
N
E
T
G
I
V
M
P
V
P
E
I
S
Q
R
I
K
A
L
N
Q
E
R
V
A
A
G
L
---------
P
P
I
L
V
-
H
T
D
A
A
Q
A
L
G
K
Q
-
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
I
R
GLG----
E
F
T
--
P
-------
L
Y
P
M
---
L
F
---
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
E
L
V
T
Q
N
-
C
E
A
Y
E
A
H
M
R
D
V
R
D
Y
L
E
E
R
L
E
A
E
FGQ
K
R
I
H
L
N
S
Q
F
P
G
----
T
Q
R
---
L
---
P
N
T
C
N
F
S
I
R
G
--
P
R
--
L
Q
G
H
V
V
L
A
Q
C
R
V
L
M
A
S
V
G
A
A
C
-
H
S
D
H
G
D
Q
P
S
P
V
L
L
S
Y
G
V
P
F
D
V
A
R
N
A
L
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
V
V
Q
D
L
K
Q
A
V
A
Q
L
E
D
Q
---
27
PsiBlast_CBE
80.04
31%
-75
- C1 -
4ISY
2
ISCSL_MYCTU
B:
[14-385]
---
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
T
--
I
--------
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
----
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
--
Y
-------
W
A
R
-------
R
D
A
E
-
P
------
H
RR
R
I
-
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
-
H
E
G
A
-
H
V
T
W
L
P
------
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
---
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
-
V
V
---------
A
M
E
---------
F
G
V
P
M
-
H
S
D
A
I
Q
A
V
G
Q
L
P
L
-
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
-------
R
D
V
--
T
-------
C
V
P
L
---
M
H
---
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
G
V
L
------
A
E
I
D
D
V
C
L
-
N
G
----
A
D
D
PMR
L
A
--
G
N
-
A
H
F
T
F
R
G
--
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
-
11
PsiBlast_PDB
79.84
30%
-82
- C1 -
3A9Z
5
SCLY_RAT
A:
[20-427]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
E
--
A
-------
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
----
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
-------
F
H
E
-------
Q
Q
T
L
-
Q
T
R
P
---
H
---
F
-
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
-
D
-
Q
V
A
E
V
T
F
V
P
------
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
P
--
T
T
C
---
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
---------
P
R
V
L
V
-
H
T
D
A
A
Q
A
L
G
K
R
R
V
-
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
-------
G
V
G
--
K
-------
L
T
P
L
Y
P
M
L
F
---
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
-
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
E
A
E
FG-
K
R
I
H
L
N
S
R
F
P
G
----
V
E
R
---
L
---
P
N
T
C
N
F
S
I
Q
G
SQ
L
R
--
G
Y
M
V
L
--
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
-
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
--
10
PsiBlast_PDB
79.28
30%
-83
- C1 -
3A9X
3
SCLY_RAT
A:
[20-427]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
E
--
A
-------
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
----
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
-------
F
H
E
-------
Q
Q
T
L
-
Q
GEG
T
R
P
H
---
F
-
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
-
D
-
Q
V
A
E
V
T
F
V
P
------
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
P
--
T
T
C
---
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
---------
P
R
V
L
V
-
H
T
D
A
A
Q
A
L
G
K
R
R
V
-
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
-------
G
V
G
--
K
-------
L
T
P
L
Y
P
M
L
F
---
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
-
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
E
A
E
FG-
K
R
I
H
L
N
S
R
F
P
G
----
V
E
R
---
L
---
P
N
T
C
N
F
S
I
Q
G
SQ
L
R
--
G
Y
M
V
L
--
A
Q
C
Q
T
L
L
A
S
V
G
A
--------------------
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
--
35
HHSearch
78.69
31%
-71
- C1 -
3A9Z
5
SCLY_RAT
A:
[19-430]
-
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
E
--
A
-------
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
----
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
--
V
-------
R
C
F
H
E
Q
Q
T
L
Q--
T
R
-
P
------
H
---
F
-
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
-
V
A
-
E
V
T
F
V
P
------
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
P
--
T
T
C
---
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
---------
K
A
L
N
Q
I
R
A
A
S
GL
P
R
V
L
V
-
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
-
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
-------
G
V
G
--
K
-------
L
T
P
L
---
Y
P
MLF
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
-
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
------
E
A
E
F
G
K
R
I
H
L
N
SRFP
G
V
E
---
R
L
--
P
N
T
C
N
F
S
I
Q
G
--
S
Q
LR
G
Y
M
V
L
A
Q
--
C
Q
T
L
L
A
S
V
G
A
S
C
-
H
S
D
H
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
--
28
PsiBlast_CBE
72.55
31%
-80
- C1 -
3VAX
2
?
B:
[22-375]
--
T
Y
L
D
A
A
A
T
T
-------
R
V
D
Q
R
V
A
D
I
--
V
LHWMTAE
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
----
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
--
A
-------
P
Y
G
-------
E
R
T
G
-
R
R-----
H
---
I
-
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
A
G
-
R
-
G
F
-
E
V
D
F
L
T
------
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
P
--
D
T
L
---
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
---------
R
A
T
---------
P
T
Y
-
L
-
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
--
L
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
RREEMDD
E
R
V
--
P
-------
L
E
P
I
---
M
F
---
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
-
H
A
Q
W
Q
V
A
A
Q
D
L
R
S
R
L
L
A
G
L
------
A
S
T
-
S
F
Q
V
N
G
D
----
Q
D
H
---
V
V
--
P
H
I
L
N
L
S
F
E
D
--
V
D
--
A
E
A
F
L
V
T
L
K
D
L
-
V
A
V
A
T
G
S
A
S
-
T
S
A
S
F
-
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
32
HHSearch
71.18
30%
-75
- C1 -
3VAX
1
?
A:
[22-379]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
A
--
E
-------
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
----
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
--
A
-------
P
Y
G
-------
E
R
T
G
R
R
------
H
---
I
-
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
A
G
-
R
-
G
F
-
E
V
D
F
L
T
------
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
P
--
D
T
L
---
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
---------
R
A
T
----------
P
T
Y
L
-
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
T
-
T
-
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
-------
R
R
E
--
E
MDDERVP
L
E
P
I
---
M
F
---
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
-
H
A
Q
W
Q
V
A
A
Q
D
L
R
S
R
L
L
A
G
L
------
A
S
T
-
S
F
Q
V
N
G
D
----
Q
D
H
---
V
V
--
P
H
I
L
N
L
S
F
E
D
--
V
D
--
A
E
A
F
L
V
T
L
K
-
D
L
V
A
V
A
T
G
S
A
S
-
T
S
A
S
F
-
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
9
PsiBlast_PDB
69.90
31%
-80
- C1 -
3VAX
1
?
A:
[22-375]
--
T
Y
L
D
A
A
A
T
T
-------
R
V
D
Q
R
V
A
D
I
--
V
L
H
W
M
T
A
E
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
----
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
--
A
-------
P
Y
G
-------
E
R
T
G
-
R
R-----
H
---
I
-
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
A
G
-
R
-
G
F
-
E
V
D
F
L
T
------
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
P
--
D
T
L
---
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
---------
R
A
T
---------
P
T
Y
-
L
-
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
--
L
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
R
R
EEMDD
E
R
V
--
P
-------
L
E
P
I
---
M
F
---
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
-
H
A
Q
W
Q
V
A
A
Q
D
L
R
S
R
L
L
A
G
L
------
A
S
T
-
S
F
Q
V
N
G
D
----
Q
D
H
---
V
V
--
P
H
I
L
N
L
S
F
E
D
--
V
D
--
A
E
A
F
L
V
T
L
K
D
L
-
V
A
V
A
T
G
S
A
S
-
T
S
A
S
F
-
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------