@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1445: (2015-12-08 )
MSKQYDYIVIGGGSAGSGTANRAAMYGAKVLLIEGGQVGGTCVNLGCVPKKIMWYGAQVSETLHKYSSGYGFEVNNLNFDFTTLKANRDAYVQRSRQSYAANFERNGVEKIDGFARFIDNHTIEVNGQQYKAPHITIATGGHPLYPDIIGSELGETSDDFFGWETLPDSILIVGAGYIAAELAGVVNELGVETHLAFRKDHILRGFDDMVTSEVMAEMEKSGISLHANHVPKSLKRDEGGKLIFEAENGKTLVVDRVIWAIGRGPNVDMGLENTDIVLNDKGYIKTDEFENTSVDGVYAIGDVNGKIALTPVAIAAGRRLSERLFNHKDNEKLDYHNVPSVIFTHPVIGTVGLSEAAAIEQFGEDNIKVYTSTFTSMYTAVTTNRQAVKMKLITLGKEEKVIGLHGVGYGIDEMIQGFSVAIKMGATKADFDDTVAIHPTGSEEFVTMR
Atome Classification :
(65 SA)
.........10.....-...20......-...30...---------.---------.---------.----------.---------.40........50........60.......--.70...--.--.-...80......-------..90........100-.-....-..110.......---120-..----.--.-----.---------...130----...-----------..-----...140....---...--150........160......---------.170.......180.....---.-.---190--........200.......210.......220.......230.......240.--.---....---.------250.-----..------.--------------.....260...-..-.-.-270........-280.-......290.......300-----.-.-.----.---.-.-.310.......320.......330--........340.......350.......360...-....370..--..-.--..380---.-.-.-....----390.......-400........410.......420.......430.......---440.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSKQY
D
Y
I
V
I
GGGSAG-SGTA-N
R
A
AMY-G
A
K
V
L
L
I
E---------G---------G---------Q----------V---------G
G
T
C
VNLGCV
P
K
K
I
M
W
YG
A
Q
V
S
E
T
L
H
K
YSS--GYG
F
E
V--N--N-
L
N
F
D
F
T
T
LKAN-------
R
D
A
Y
V
Q
R
S
R
Q
S
Y
AAN-F-ERN
G
-
V
E
K
I
D
G
F
A
R
F
I
D---N
H
--
T
I
----
E
--V-----N---------G
Q
Q
YK-----A
P
H
-----------
I
T
-----
I
ATGGHPL
Y
P
---
D
I
I
--
G
S
-ELGETSDDFFGWETLPD---------
S
I
L
I
VG
A
G
Y
I
A
A
E
L
A
G
V
V
N
---
E
-L---GV---
E
T
H
L
A
F
R
K
D
H
I
LRG
F
D
D
M
V
T
S
E
V
M
A
E
M
E
KSG
I
S
L
HANHV
P
K
S
L
KRDEG
G
K
L
I
--
F
---EAEN---G------
K
--
T
-----
L
V
------
V
--------------
D
R
V
I
W
A
IGRGP-NV-D-M-GL-ENT
D
I
V
LN-DKG
Y
-
I
KTDEFENTSV
D
G
V
Y
A
I
GD-----V-N-G----
K
---
I
-
A
-
L
T
P
V
A
I
A
A
G
R
R
L
S
E
R
L
FNHKDNE---KLDYHNVPS
V
I
FTHPVIGTVGL
S
E
A
A
A
I
E
Q
FGED-
N
I
K
V
Y
T
STF--
T
S
-
M
--
Y
T
A
VT---T-N-
R
-
Q
A
V
K
----
M
K
L
I
TLGKE
E
-
K
-
V
I
G
L
HGVGY
G
I
D
E
M
I
Q
G
F
S
V
A
I
K
MGATKADFD
D
T
V
A
IHP---TGSE
E
F
V
TMR
22
PsiBlast_CBE
92.61
55%
-87
- C1 -
1GER
2
GSHR_ECOLI
B:
[2-450]
-
T
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
-
I
A
S
I
-
N
R
A
A
M
Y
-
G
Q
K
C
A
L
I
E
---------
A
---------
K
---------
E
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
--
D
Y
G
F
D
T
--
T
--
I
-
N
K
F
N
W
E
T
L
I
A
S
-------
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
---
A
K
--
T
L
----
E
--
V
-----
N
---------
G
E
T
I
T
-----
A
D
H
-----------
I
L
-----
I
A
T
G
G
R
P
S
H
P
---
D
I
P
--
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
---
G
-
L
---
G
A
---
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
T
D
G
S
L
T
--
L
---
E
L
E
D
---
G
------
R
--
S
-----
E
T
------
V
--------------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
-
N
-
I
-
N
L
-
E
A
A
G
V
K
T
N
-
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
---
V
-
E
-
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
F
N
N
K
P
D
E
---
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
-
M
--
Y
T
A
V
T
---
T
-
H
-
R
-
Q
P
C
R
----
M
K
L
V
C
V
G
S
E
E
-
K
-
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
11
PsiBlast_PDB
92.51
50%
-92
- C1 -
1BWC
3
GSHR_HUMAN
A:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
KP
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
101
HHSearch
91.82
55%
-90
- C1 -
1GES
2
GSHR_ECOLI
A:
[3-450]
--
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
-
I
A
S
I
-
N
R
A
A
M
Y
-
G
Q
K
C
A
L
I
E
---------
A
---------
K
---------
E
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
--
D
Y
G
F
D
T
--
T
--
I
-
N
K
F
N
W
E
T
L
I
A
S
-------
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
---
A
K
--
T
L
----
E
--
V
-----
N
---------
G
E
T
I
T
-----
A
D
H
-----------
I
L
-----
I
A
T
G
G
R
P
S
H
P
---
D
I
P
--
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
---
G
-
L
---
G
A
---
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
T
D
G
S
L
T
--
L
---
E
L
E
D
---
G
------
R
--
S
-----
E
T
------
V
--------------
D
C
L
I
W
A
I
G
R
E
P
-
A
N
D
N
-
I
-
N
L
-
E
A
A
G
V
K
T
N
-
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
---
V
-
E
-
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
F
N
N
K
P
D
E
---
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
-
M
--
Y
T
A
V
T
---
T
-
H
-
R
-
Q
P
C
R
----
M
K
L
V
C
V
G
S
E
E
-
K
-
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
23
PsiBlast_CBE
91.19
54%
-87
- C1 -
1GEU
3
GSHR_ECOLI
B:
[2-450]
-
T
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
-
I
A
S
I
-
N
R
A
A
M
Y
-
G
Q
K
C
A
L
I
E
---------
A
---------
K
---------
E
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
--
D
Y
G
F
D
T
--
T
--
I
-
N
K
F
N
W
E
T
L
I
A
S
-------
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
---
A
K
--
T
L
----
E
--
V
-----
N
---------
G
E
T
I
T
-----
A
D
H
-----------
I
L
-----
I
A
T
G
G
R
P
S
H
P
---
D
I
P
--
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
---
G
-
L
---
G
A
---
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
T
D
G
S
L
T
--
L
---
E
L
E
D
---
G
------
R
--
S
-----
E
T
------
V
--------------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
-
N
-
I
-
N
L
-
E
A
A
G
V
K
T
N
-
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
---
V
-
E
-
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
F
N
N
K
P
D
E
---
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
-
M
--
Y
T
A
V
T
---
T
-
H
-
R
-
Q
P
C
R
----
M
K
L
V
C
V
G
S
E
E
-
K
-
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
1
PsiBlast_PDB
91.18
55%
-87
- C1 -
1GER
2
GSHR_ECOLI
A:
[3-450]
--
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
-
I
A
S
I
-
N
R
A
A
M
Y
-
G
Q
K
C
A
L
I
E
---------
A
---------
K
---------
E
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
--
D
Y
G
F
D
T
--
T
--
I
-
N
K
F
N
W
E
T
L
I
A
S
-------
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
---
A
K
--
T
L
----
E
--
V
-----
N
---------
G
E
T
I
T
-----
A
D
H
-----------
I
L
-----
I
A
T
G
G
R
P
S
H
P
---
D
I
P
--
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
---
G
-
L
---
G
A
---
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
T
D
G
S
L
T
--
L
---
E
L
E
D
---
G
------
R
--
S
-----
E
T
------
V
--------------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
-
N
-
I
-
N
L
-
E
A
A
G
V
K
T
N
-
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
---
V
-
E
-
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
F
N
N
K
P
D
E
---
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
-
M
--
Y
T
A
V
T
---
T
-
H
-
R
-
Q
P
C
R
----
M
K
L
V
C
V
G
S
E
E
-
K
-
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
21
PsiBlast_CBE
90.45
55%
-86
- C1 -
1GET
3
GSHR_ECOLI
B:
[2-450]
-
T
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
-
I
A
S
I
-
N
R
A
A
M
Y
-
G
Q
K
C
A
L
I
E
---------
A
---------
K
---------
E
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
--
D
Y
G
F
D
T
--
T
--
I
-
N
K
F
N
W
E
T
L
I
A
S
-------
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
---
A
K
--
T
L
----
E
--
V
-----
N
---------
G
E
T
I
T
-----
A
D
H
-----------
I
L
-----
I
A
T
G
G
R
P
S
H
P
---
D
I
P
--
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
---
G
-
L
---
G
A
---
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
T
D
G
S
L
T
--
L
---
E
L
E
D
---
G
------
R
--
S
-----
E
T
------
V
--------------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
-
N
-
I
-
N
L
-
E
A
A
G
V
K
T
N
-
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
---
V
-
E
-
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
F
N
N
K
P
D
E
---
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
-
M
--
Y
T
A
V
T
---
T
-
H
-
R
-
Q
P
C
R
----
M
K
L
V
C
V
G
S
E
E
-
K
-
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
24
PsiBlast_CBE
90.44
54%
-87
- C1 -
1GES
2
GSHR_ECOLI
B:
[2-450]
-
T
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
-
I
A
S
I
-
N
R
A
A
M
Y
-
G
Q
K
C
A
L
I
E
---------
A
---------
K
---------
E
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
--
D
Y
G
F
D
T
--
T
--
I
-
N
K
F
N
W
E
T
L
I
A
S
-------
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
---
A
K
--
T
L
----
E
--
V
-----
N
---------
G
E
T
I
T
-----
A
D
H
-----------
I
L
-----
I
A
T
G
G
R
P
S
H
P
---
D
I
P
--
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
---
G
-
L
---
G
A
---
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
T
D
G
S
L
T
--
L
---
E
L
E
D
---
G
------
R
--
S
-----
E
T
------
V
--------------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
-
N
-
I
-
N
L
-
E
A
A
G
V
K
T
N
-
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
---
V
-
E
-
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
F
N
N
K
P
D
E
---
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
-
M
--
Y
T
A
V
T
---
T
-
H
-
R
-
Q
P
C
R
----
M
K
L
V
C
V
G
S
E
E
-
K
-
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
3
PsiBlast_PDB
89.73
54%
-88
- C1 -
1GES
2
GSHR_ECOLI
A:
[3-450]
--
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
-
I
A
S
I
-
N
R
A
A
M
Y
-
G
Q
K
C
A
L
I
E
---------
A
---------
K
---------
E
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
--
D
Y
G
F
D
T
--
T
--
I
-
N
K
F
N
W
E
T
L
I
A
S
-------
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
---
A
K
--
T
L
----
E
--
V
-----
N
---------
G
E
T
I
T
-----
A
D
H
-----------
I
L
-----
I
A
T
G
G
R
P
S
H
P
---
D
I
P
--
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
---
G
-
L
---
G
A
---
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
T
D
G
S
L
T
--
L
---
E
L
E
D
---
G
------
R
--
S
-----
E
T
------
V
--------------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
-
N
-
I
-
N
L
-
E
A
A
G
V
K
T
N
-
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
---
V
-
E
-
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
F
N
N
K
P
D
E
---
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
-
M
--
Y
T
A
V
T
---
T
-
H
-
R
-
Q
P
C
R
----
M
K
L
V
C
V
G
S
E
E
-
K
-
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
2
PsiBlast_PDB
89.57
55%
-88
- C1 -
1GET
3
GSHR_ECOLI
A:
[3-450]
--
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
-
I
A
S
I
-
N
R
A
A
M
Y
-
G
Q
K
C
A
L
I
E
---------
A
---------
K
---------
E
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
--
D
Y
G
F
D
T
--
T
--
I
-
N
K
F
N
W
E
T
L
I
A
S
-------
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
---
A
K
--
T
L
----
E
--
V
-----
N
---------
G
E
T
I
T
-----
A
D
H
-----------
I
L
-----
I
A
T
G
G
R
P
S
H
P
---
D
I
P
--
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
---
G
-
L
---
G
A
---
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
T
D
G
S
L
T
--
L
---
E
L
E
D
---
G
------
R
--
S
-----
E
T
------
V
--------------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
-
N
-
I
-
N
L
-
E
A
A
G
V
K
T
N
-
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
---
V
-
E
-
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
F
N
N
K
P
D
E
---
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
-
M
--
Y
T
A
V
T
---
T
-
H
-
R
-
Q
P
C
R
----
M
K
L
V
C
V
G
S
E
E
-
K
-
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
12
PsiBlast_PDB
89.04
50%
-91
- C1 -
2GH5
13
GSHR_HUMAN
A:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
KP
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
31
PsiBlast_CBE
88.86
50%
-89
- C1 -
1XAN
2
GSHR_HUMAN
A:
[3-461]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
20
PsiBlast_PDB
88.82
50%
-91
- C1 -
3DK4
5
GSHR_HUMAN
A:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
114
HHSearch
88.53
51%
-86
- C1 -
3DK9
4
GSHR_HUMAN
A:
[18-478]
-
V
A
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
-
H
D
H
A
--
D
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
DP-
K
P
--
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
-
L
E
--
V
S
M
V
T
A
V
P
---
G
R
L
P
V
M
T
M
--
I
-----
P
D
------
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
-
G
I
E
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
4
PsiBlast_PDB
87.83
54%
-87
- C1 -
1GEU
3
GSHR_ECOLI
A:
[3-450]
--
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
-
I
A
S
I
-
N
R
A
A
M
Y
-
G
Q
K
C
A
L
I
E
---------
A
---------
K
---------
E
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
--
D
Y
G
F
D
T
--
T
--
I
-
N
K
F
N
W
E
T
L
I
A
S
-------
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
V
D
---
A
K
--
T
L
----
E
--
V
-----
N
---------
G
E
T
I
T
-----
A
D
H
-----------
I
L
-----
I
A
T
G
G
R
P
S
H
P
---
D
I
P
--
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
---
G
-
L
---
G
A
---
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
T
D
G
S
L
T
--
L
---
E
L
E
D
---
G
------
R
--
S
-----
E
T
------
V
--------------
D
C
L
I
W
A
I
G
R
E
P
A
N
D
-
N
-
I
-
N
L
-
E
A
A
G
V
K
T
N
-
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
---
V
-
E
-
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
F
N
N
K
P
D
E
---
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
-
M
--
Y
T
A
V
T
---
T
-
H
-
R
-
Q
P
C
R
----
M
K
L
V
C
V
G
S
E
E
-
K
-
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
---
T
A
A
E
E
F
V
T
M
R
28
PsiBlast_CBE
87.76
50%
-89
- C1 -
3DK8
8
GSHR_HUMAN
A:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
25
PsiBlast_CBE
87.75
50%
-87
- C1 -
3SQP
6
GSHR_HUMAN
B:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
KP
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
HES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
SM
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
MTMIPD
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
29
PsiBlast_CBE
87.65
50%
-88
- C1 -
3DJG
2
GSHR_HUMAN
X:
[19-477]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
KP
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
HES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
SM
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
MTMIPD
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
26
PsiBlast_CBE
87.61
50%
-87
- C1 -
3SQP
6
GSHR_HUMAN
A:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
9
PsiBlast_PDB
87.59
50%
-87
- C1 -
5GRT
2
GSHR_HUMAN
A:
[3-461]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
E
S
A
-
W
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
KP
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
13
PsiBlast_PDB
87.53
50%
-90
- C1 -
1GRA
4
GSHR_HUMAN
A:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
14
PsiBlast_PDB
87.45
50%
-88
- C1 -
1GRB
3
GSHR_HUMAN
A:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
30
PsiBlast_CBE
87.32
50%
-88
- C1 -
2GH5
14
GSHR_HUMAN
B:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
KP
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
HES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
SM
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
MTMIPD
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
27
PsiBlast_CBE
87.26
50%
-87
- C1 -
3DK9
4
GSHR_HUMAN
A:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
17
PsiBlast_PDB
87.12
50%
-87
- C1 -
3GRS
2
GSHR_HUMAN
A:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
5
PsiBlast_PDB
87.02
50%
-86
- C1 -
1GRT
1
GSHR_HUMAN
A:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
E
S
A
-
W
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
IPD
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
19
PsiBlast_PDB
87.00
50%
-87
- C1 -
3DJJ
19
GSHR_HUMAN
A:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
16
PsiBlast_PDB
86.95
50%
-89
- C1 -
1GRF
3
GSHR_HUMAN
A:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
18
PsiBlast_PDB
86.57
50%
-89
- C1 -
4GR1
3
GSHR_HUMAN
A:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
KP
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
6
PsiBlast_PDB
86.54
50%
-87
- C1 -
2GRT
2
GSHR_HUMAN
A:
[3-461]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
E
S
A
-
W
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
15
PsiBlast_PDB
86.47
50%
-88
- C1 -
1GRE
4
GSHR_HUMAN
A:
[20-478]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
7
PsiBlast_PDB
86.47
50%
-88
- C1 -
3GRT
2
GSHR_HUMAN
A:
[3-461]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
E
S
A
-
W
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
IPD
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
10
PsiBlast_PDB
85.94
50%
-87
- C1 -
2AAQ
13
GSHR_HUMAN
A:
[21-479]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
A
S
A
-
R
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
KP
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
32
PsiBlast_CBE
84.23
46%
-82
- C1 -
2R9Z
8
GASHR_MARGR
B:
[2-448]
-
T
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
-
L
A
V
A
-
E
K
A
A
A
F
-
G
K
R
V
A
L
I
E
---------
S
---------
K
---------
A
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
A
S
H
L
A
E
A
V
-
R
D
A
P
--
G
F
G
V
Q
A
--
S
--
G
--
T
L
D
W
P
R
L
V
A
G
-------
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
-
V
-
E
R
L
G
-
I
T
R
V
D
G
H
A
R
F
V
D
---
A
H
--
T
I
----
E
--
V
-----
E
---------
G
Q
R
L
S
-----
A
D
H
-----------
I
V
-----
I
A
T
G
G
R
P
I
V
P
---
R
L
P
--
G
A
-
E
L
G
I
T
S
D
G
F
F
A
L
Q
Q
Q
P
K
---------
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
---
S
-
F
---
G
S
---
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
E
R
D
A
Q
G
T
T
L
--
V
---
A
Q
D
G
---
T
------
R
--
L
-----
E
G
------
F
--------------
D
S
V
I
W
A
V
G
R
A
P
-
N
T
R
D
-
L
-
G
L
-
E
A
A
G
I
E
V
Q
-
S
N
G
M
-
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
-----
I
-
T
-
G
----
R
---
D
-
Q
-
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
F
D
G
Q
S
E
R
---
K
L
D
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
-
D
-
V
L
T
V
Y
E
T
S
F
--
T
P
-
M
--
R
Y
A
L
N
---
E
-
H
-
G
-
P
K
T
A
----
M
K
L
V
C
A
G
P
E
Q
-
R
-
V
V
G
V
H
V
I
G
D
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
E
L
V
T
L
K
123
Fugue
83.89
52%
-86
- C1 -
1GER
2
GSHR_ECOLI
A:
[3-450]
--
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
-
I
A
S
I
-
N
R
A
A
M
Y
-
G
Q
K
C
A
L
I
E
---------
A
---------
K
----------E---------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
DY
G
F
D
T
T
I
-------
N
K
F
N
W
E
T
L
I
A
S
-------
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
V
D
V
I
K
-
G
F
A
R
F
V
-DAK----
T
L
----
E
--
V
-----
N
---------
G
E
T
I
T
-----
A
D
H
-----------
I
L
-----
I
A
T
G
G
R
P
S
H
P
---
D
-----
I
-
P
-
G
V
--
E
Y
G
I
D
---
S
D
G
F
F
A
LPALPE
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
N
---
G
L
----
G
A
---
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
T
D
G
S
L
T
--
L
---
E
L
E
D
----G
R
----
S
--
E
-----
T
-------
V
--------------
D
C
L
I
W
A
I
G
R
E
P
-
A
N
-
D
-
N
I
N
L
-
E
A
A
G
V
K
T
N
-
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
----V
E
-
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
F
N
---
N
K
PDE
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
--MY
T
A
V
T
T
---
H
-
R
---
Q
P
C
R
----
M
K
L
V
C
V
G
S
E
E
-
K
-
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
--
V
A
I
H
PT-
A
A
E
E
F
V
T
M
R
117
HHSearch
83.56
47%
-83
- C1 -
2R9Z
8
GASHR_MARGR
A:
[2-448]
-
T
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
-
L
A
V
A
-
E
K
A
A
A
F
-
G
K
R
V
A
L
I
E
---------
S
---------
K
---------
A
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
A
S
H
L
A
E
A
V
-
R
D
A
P
--
G
F
G
V
Q
A
--
S
------
L
D
W
P
R
L
V
A
G
-------
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
-
V
-
E
R
L
G
-
I
T
R
V
D
G
H
A
R
F
V
D
---
A
H
--
T
I
----
E
--
V
-----
E
---------
G
Q
R
L
S
-----
A
D
H
-----------
I
V
-----
I
A
T
G
G
R
P
I
V
P
---
R
L
P
--
G
A
-
E
L
G
I
T
S
D
G
F
F
A
L
Q
Q
Q
P
K
---------
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
---
S
-
F
---
G
S
---
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
E
R
D
A
Q
G
-
T
T
--
L
---
V
A
Q
D
---
G
------
T
--
R
L
----
E
G
------
F
--------------
D
S
V
I
W
A
V
G
R
A
P
-
N
T
R
D
-
L
-
G
L
-
E
A
A
G
I
E
V
Q
-
S
N
G
M
-
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
-----
I
-
T
-
G
----
R
---
D
-
Q
-
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
F
D
G
Q
S
E
R
---
K
L
D
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
D
--
V
L
T
V
Y
E
T
S
F
--
T
P
-
M
--
R
Y
A
L
N
---
E
-
H
-
G
-
P
K
T
A
----
M
K
L
V
C
A
G
P
E
Q
-
R
-
V
V
G
V
H
V
I
G
D
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
E
L
V
T
L
K
8
PsiBlast_PDB
83.38
50%
-86
- C1 -
4GRT
2
GSHR_HUMAN
A:
[3-461]
---
S
Y
D
Y
L
V
I
G
G
G
S
G
G
-
L
E
S
A
-
W
R
A
A
E
L
-
G
A
R
A
A
V
V
E
---------
S
---------
H
---------
K
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
S
--
C
--
E
-
G
K
F
N
W
R
V
I
K
E
K
-------
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
T
S
---
D
P
K
P
T
I
----
E
--
V
-----
S
---------
G
K
K
Y
T
-----
A
P
H
-----------
I
L
-----
I
A
T
G
G
M
P
S
T
P
H
ES
Q
I
P
--
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
S
---
A
-
L
---
G
S
---
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
M
V
---
T
A
V
P
---
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
--------------
D
C
L
L
W
A
I
G
R
V
P
-
N
T
K
D
-
L
-
S
L
-
N
K
L
G
I
Q
T
D
-
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
---
A
-
L
-
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
F
E
Y
K
E
D
S
---
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
-
M
--
Y
H
A
V
T
---
K
-
R
-
K
-
T
K
C
V
----
M
K
M
V
C
A
N
K
E
E
-
K
-
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
T
S
S
E
E
L
V
T
L
R
33
PsiBlast_CBE
82.27
46%
-82
- C1 -
2R9Z
8
GASHR_MARGR
A:
[2-448]
-
T
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
-
L
A
V
A
-
E
K
A
A
A
F
-
G
K
R
V
A
L
I
E
---------
S
---------
K
---------
A
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
A
S
H
L
A
E
A
V
-
R
D
A
P
--
G
F
G
V
Q
A
--
S
------
L
D
W
P
R
L
V
A
G
-------
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
-
V
-
E
R
L
G
-
I
T
R
V
D
G
H
A
R
F
V
D
---
A
H
--
T
I
----
E
--
V
-----
E
---------
G
Q
R
L
S
-----
A
D
H
-----------
I
V
-----
I
A
T
G
G
R
P
I
V
P
---
R
L
P
--
G
A
-
E
L
G
I
T
S
D
G
F
F
A
L
Q
Q
Q
P
K
---------
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
R
---
S
-
F
---
G
S
---
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
E
R
D
A
Q
G
T
T
L
--
V
---
A
Q
D
G
---
T
------
R
--
L
-----
E
G
------
F
--------------
D
S
V
I
W
A
V
G
R
A
P
-
N
T
R
D
-
L
-
G
L
-
E
A
A
G
I
E
V
Q
-
S
N
G
M
-
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
-----
I
-
T
-
G
----
R
---
D
-
Q
-
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
F
D
G
Q
S
E
R
---
K
L
D
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
-
D
-
V
L
T
V
Y
E
T
S
F
--
T
P
-
M
--
R
Y
A
L
N
---
E
-
H
-
G
-
P
K
T
A
----
M
K
L
V
C
A
G
P
E
Q
-
R
-
V
V
G
V
H
V
I
G
D
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
---
G
S
A
E
E
L
V
T
L
K
93
PsiBlast_CBE
77.19
35%
-85
- C1 -
1ZKQ
1
TRXR2_MOUSE
A:
[31-500]
--
Q
S
F
D
L
L
V
I
G
G
G
S
G
G
-
L
A
C
A
-
K
E
A
A
Q
L
-
G
K
K
V
A
V
A
D
---------
Y
---------
V
---------
E
PSPR
G
T
K
W
G
-
L
---------
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
A
L
L
G
G
M
I
-
R
D
A
H
--
H
Y
G
W
E
V
A-
Q
--
P
-
V
Q
H
N
W
K
T
M
A
E
A
-------
V
Q
N
H
V
K
S
L
N
W
G
H
R
V
Q
-
L
-
Q
D
R
K
-
V
K
Y
F
N
I
K
A
S
F
V
D
---
E
H
--
T
V
----
R
--
G
V
D
KG
G
K
---------
A
T
L
L
S
-----
A
E
H
-----------
I
V
-----
I
A
T
G
G
R
P
R
Y
P
---
T
Q
V
KG
A
L
-
E
Y
G
I
T
S
D
D
I
F
W
L
K
E
S
P
G
---------
K
T
L
V
V
G
A
S
Y
V
A
L
E
C
A
G
F
L
T
---
G
-
I
---
G
L
---
D
T
T
V
M
M
R
S
I
P
-
L
R
G
F
D
Q
Q
M
S
S
L
V
T
E
H
M
E
S
H
G
T
Q
F
L
K
G
C
V
P
S
H
I
K
K
L
P
T
N
Q
L
Q
--
V
---
T
W
E
D
HAS
G
------
K
E
D
T
-----
G
T
------
F
--------------
D
T
V
L
W
A
I
G
R
V
P
-
E
T
R
T
-
L
-
N
L
-
E
K
A
G
I
S
T
N
-
P
K
N
Q
K
I
I
V
D
A
Q
E
A
T
S
V
P
H
I
Y
A
I
G
D
-----
V
A
E
-
G
----
R
---
P
-
E
-
L
T
P
T
A
I
K
A
G
K
L
L
A
Q
R
L
F
G
-
K
S
S
T
---
L
M
D
Y
S
N
V
P
T
T
V
F
T
P
L
E
Y
G
C
V
G
L
S
E
E
E
A
V
A
L
H
G
Q
E
-
H
V
E
V
Y
H
A
Y
Y
--
K
P
-
L
E
-
F
T
V
A
D
---
R
-
D
-
A
-
S
Q
C
Y
----
I
K
M
V
C
M
R
E
P
P
-
Q
L
V
L
G
L
H
F
L
G
P
N
A
G
E
V
T
Q
G
F
A
L
G
I
K
C
G
A
S
Y
A
Q
V
M
Q
T
V
G
I
H
P
---
T
C
S
E
E
V
V
K
L
H
105
HHSearch
76.55
42%
-85
- C1 -
1ONF
1
GSHR_PLAFK
A:
[2-496]
---
V
Y
D
L
I
V
I
G
G
G
S
G
G
-
M
A
A
A
-
R
R
A
A
R
H
-
N
A
K
V
A
L
V
E
---------
K
---------
S
---------
R
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
I
M
F
N
A
A
S
V
H
D
I
L
-
E
N
S
R
--
H
Y
G
F
D
T
-----
K
-
F
S
F
N
L
P
L
L
V
E
R
-------
R
D
K
Y
I
Q
R
L
N
N
I
Y
R
Q
N
-
L
-
S
K
D
K
-
V
D
L
Y
E
G
T
A
S
F
L
-------------------------------------
E
-----
G
R
N
-----------
I
L
-----
I
A
V
G
N
K
P
V
F
P
---
P
V
K
--
G
I
-
E
N
T
I
S
S
D
E
F
F
N
I
K
-
E
S
K
---------
K
I
G
I
V
G
S
G
Y
I
A
V
E
L
I
N
V
I
K
---
R
-
L
---
G
I
---
D
S
Y
I
F
A
R
G
N
R
I
L
R
K
F
D
E
S
V
I
N
V
L
E
N
D
M
K
K
N
N
I
N
I
V
T
F
A
D
V
V
E
I
K
K
V
S
D
K
N
L
S
--
I
---
H
L
S
D
---
G
------
R
--
I
Y
----
E
H
------
F
--------------
D
H
V
I
Y
C
V
G
R
S
P
-
D
T
E
N
-
L
-
K
L
-
E
K
L
N
V
E
T
N
--
N
N
Y
-
I
V
V
D
E
N
Q
R
T
S
V
N
N
I
Y
A
V
G
D
-----
C
-
C
-
M
VKF
Y
N
---
V
-
Q
-
L
T
P
V
A
I
N
A
G
R
L
L
A
D
R
L
F
L
K
K
T
-
R
---
K
T
N
Y
K
L
I
P
T
V
I
F
S
H
P
P
I
G
T
I
G
L
S
E
E
A
A
I
Q
I
Y
G
K
E
-
N
V
K
I
Y
E
S
K
F
--
T
N
-
L
--
F
F
S
V
Y
DIE
P
E
L
-
K
-
E
K
T
Y
----
L
K
L
V
C
V
G
K
D
E
-
L
-
I
K
G
L
H
I
I
G
L
N
A
D
E
I
V
Q
G
F
A
V
A
L
K
M
N
A
T
K
K
D
F
D
E
T
I
P
I
H
P
---
T
A
A
E
E
F
L
T
L
Q
39
PsiBlast_CBE
75.77
36%
-85
- C1 -
3DGH
5
TRXR1_DROME
A:
[7-474]
-
S
Y
D
Y
D
L
I
V
I
G
G
G
S
A
G
-
L
A
C
A
-
K
E
A
V
L
N
-
G
A
R
V
A
C
L
D
---------
F
---------
V
---------
K
P
T
PTLG
T
K
W
G
V
---------
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
S
L
L
G
E
A
V
H
E
-
A
A
--
A
Y
G
W
N
V
--
D
--
D
K
I
K
P
D
W
H
K
L
V
Q
S
-------
V
Q
N
H
I
K
S
V
N
W
V
T
R
V
D
-
L
-
R
D
K
K
-
V
E
Y
I
N
G
L
G
S
F
V
D
---
S
H
--
T
L
L
A
K
L
K
--
S
-----
G
---------
E
R
T
I
T
-----
A
Q
T
-----------
F
V
-----
I
A
V
G
G
R
P
R
Y
P
---
D
I
P
--
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
D
R
E
P
G
---------
K
T
L
V
V
G
A
G
Y
I
G
L
E
C
A
G
F
L
K
---
G
-
L
---
G
Y
---
E
P
T
V
M
V
R
S
-
I
V
L
R
G
F
D
Q
Q
M
A
E
L
V
A
A
S
M
E
E
R
G
I
P
F
L
R
K
T
V
P
L
S
V
E
K
Q
D
D
G
K
L
L
--
V
---
K
Y
K
N
---
V
------
E
--
T
G
E
E
S
E
D
V
------
Y
--------------
D
T
V
L
W
A
I
G
R
K
G
-
L
V
-
D
D
L
-
N
L
-
P
N
A
G
V
T
V
Q
--
K
D
K
-
I
P
V
D
S
Q
E
A
T
N
V
A
N
I
Y
A
V
G
D
-----
I
I
Y
-
G
----
K
---
P
-
E
-
L
T
P
V
A
V
L
A
G
R
L
L
A
R
R
L
Y
G
-
G
S
T
Q
---
R
M
D
Y
K
D
V
A
T
T
V
F
T
P
L
E
Y
A
C
V
G
L
S
E
E
D
A
V
K
Q
F
G
A
D
-
E
I
E
V
F
H
G
Y
Y
K
P
T
E
-
F
--
F
I
P
Q
K
---
S
-
V
-
R
-
Y
C
Y
L
----
K
A
V
A
E
R
H
G
D
Q
-
R
-
V
Y
G
L
H
Y
I
G
P
V
A
G
E
V
I
Q
G
F
A
A
A
L
K
S
G
L
T
I
N
T
L
I
N
T
V
G
I
H
P
---
T
T
A
E
E
F
T
R
L
A
38
PsiBlast_CBE
75.13
36%
-85
- C1 -
3DGH
4
TRXR1_DROME
B:
[7-474]
-
S
Y
D
Y
D
L
I
V
I
G
G
G
S
A
G
-
L
A
C
A
-
K
E
A
V
L
N
-
G
A
R
V
A
C
L
D
---------
F
---------
V
---------
K
PTPTLGTKWG
V
---------
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
S
L
L
G
E
A
V
H
E
-
A
A
--
A
Y
G
W
N
V
--
D
--
D
K
I
K
P
D
W
H
K
L
V
Q
S
-------
V
Q
N
H
I
K
S
V
N
W
V
T
R
V
D
-
L
-
R
D
K
K
-
V
E
Y
I
N
G
L
G
S
F
V
D
---
S
H
--
T
L
LAKL
K
--
S
-----
G
---------
E
R
T
I
T
-----
A
Q
T
-----------
F
V
-----
I
A
V
G
G
R
P
R
Y
P
---
D
I
P
--
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
D
R
E
P
G
---------
K
T
L
V
V
G
A
G
Y
I
G
L
E
C
A
G
F
L
K
---
G
-
L
---
G
Y
---
E
P
T
V
M
V
R
S
-
I
V
L
R
G
F
D
Q
Q
M
A
E
L
V
A
A
S
M
E
E
R
G
I
P
F
L
R
K
T
V
P
L
S
V
E
K
Q
D
D
G
K
L
L
--
V
---
K
Y
K
N
---
V
------
E
--
T
GEESE
D
V
------
Y
--------------
D
T
V
L
W
A
I
G
R
K
G
-
L
V
-
D
D
L
-
N
L
-
P
N
A
G
V
T
V
Q
--
K
D
K
-
I
P
V
D
S
Q
E
A
T
N
V
A
N
I
Y
A
V
G
D
-----
I
I
Y
-
G
----
K
---
P
-
E
-
L
T
P
V
A
V
L
A
G
R
L
L
A
R
R
L
Y
G
-
G
S
T
Q
---
R
M
D
Y
K
D
V
A
T
T
V
F
T
P
L
E
Y
A
C
V
G
L
S
E
E
D
A
V
K
Q
F
G
A
D
-
E
I
E
V
F
H
G
Y
Y
KP
T
E
-
F
--
F
I
P
Q
K
---
S
-
V
-
R
-
Y
C
Y
L
----
K
A
V
A
E
R
H
G
D
Q
-
R
-
V
Y
G
L
H
Y
I
G
P
V
A
G
E
V
I
Q
G
F
A
A
A
L
K
S
G
L
T
I
N
T
L
I
N
T
V
G
I
H
P
---
T
T
A
E
E
F
T
R
L
A
34
PsiBlast_CBE
74.98
37%
-91
- C1 -
1ONF
1
GSHR_PLAFK
A:
[3-496]
----
Y
D
L
I
V
I
G
G
G
S
G
G
-
M
A
A
A
-
R
R
A
A
R
H
-
N
A
K
V
A
L
V
E
---------
K
---------
S
---------
R
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
I
M
F
N
A
A
S
V
H
D
I
L
E
N
-
S
R
--
H
Y
G
F
D
T
-----
K
-
F
S
F
N
L
P
L
L
V
E
R
-------
R
D
K
Y
I
Q
R
L
N
N
I
Y
R
Q
N
-
L
-
S
K
D
K
-
V
D
L
Y
E
G
T
A
S
F
L
-------------------------------------
E
-----
G
R
N
-----------
I
L
-----
I
A
V
G
N
K
P
V
F
P
---
P
V
K
--
G
I
-
E
N
T
I
S
S
D
E
F
F
N
I
K
E
-
S
K
---------
K
I
G
I
V
G
S
G
Y
I
A
V
E
L
I
N
V
I
K
---
R
-
L
---
G
I
---
D
S
Y
I
F
A
R
G
N
R
I
L
R
K
F
D
E
S
V
I
N
V
L
E
N
D
M
K
K
N
N
I
N
I
V
T
F
A
D
V
V
E
I
K
K
V
S
D
K
N
L
S
--
I
---
H
L
S
D
---
G
------
R
--
I
-----
Y
E
H-----
F
--------------
D
H
V
I
Y
C
V
G
R
S
P
-
D
T
-
E
N
L
-
K
L
-
E
K
L
N
V
E
T
N
-
N
-
N
Y
-
I
V
V
D
E
N
Q
R
T
S
V
N
N
I
Y
A
V
G
D
CCMVK----------F
Y
N
V
-
Q
-
L
T
P
V
A
I
N
A
G
R
L
L
A
D
R
L
F
-
L
K
K
T
R
---
K
T
N
Y
K
L
I
P
T
V
I
F
S
H
P
P
I
G
T
I
G
L
S
E
E
A
A
I
Q
I
Y
G
K
E
-
N
V
K
I
Y
E
S
K
F
--
T
N
-
L
--
F
F
S
V
Y
---
D
-
I
-
E
-
P
E
L
K
E
K
T
Y
L
K
L
V
C
V
G
K
D
E
-
L
-
I
K
G
L
H
I
I
G
L
N
A
D
E
I
V
Q
G
F
A
V
A
L
K
M
N
A
T
K
K
D
F
D
E
T
I
P
I
H
P
---
T
A
A
E
E
F
L
T
L
Q
46
PsiBlast_CBE
73.80
33%
-98
- C1 -
4B1B
1
TRXR_PLAF5
B:
[43-506]
----
Y
D
Y
V
V
I
G
G
G
P
G
G
-
M
A
S
A
-
K
E
A
A
A
H
-
G
A
R
V
L
L
F
D
---------
Y
---------
V
---------
K
PSSQGTKWG-
I
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
H
Y
A
G
H
M
G
S
I
F
K
L
D
S
K
--
A
Y
G
W
K
F
--
D
--
N
-
L
K
H
D
W
K
K
L
V
T
T
-------
V
Q
S
H
I
R
S
L
N
F
S
Y
M
T
G
-
L
-
R
S
S
K
-
V
K
Y
I
N
G
L
A
K
L
K
D
---
K
N
--
T
V
----
S
YY
L
-----
K
-----------
L
S
K
EETVT
G
K
Y
-----------
I
L
-----
I
A
T
G
C
R
P
H
I
P
---
D
D
V
EG
A
K
-
E
L
S
I
T
S
D
D
I
F
S
L
K
K
D
P
G
---------
K
T
L
V
V
G
A
S
Y
V
A
L
E
C
S
G
F
L
N
---
S
-
L
---
G
Y
---
D
V
T
V
A
V
R
-
S
I
V
L
R
G
F
D
Q
Q
C
A
V
K
V
K
L
Y
M
E
E
Q
G
V
M
F
K
N
G
I
L
P
K
K
L
T
K
M
D
-
D
K
I
L
--
V
---
E
F
S
D
---
K
------
T
--
S
-----
E
L
------
Y
--------------
D
T
V
L
Y
A
I
G
R
K
G
-
D
I
-
D
G
L
-
N
L
-
E
S
L
N
M
N
V
N
K
S
N
N
K
-
I
I
A
D
H
L
S
C
T
N
I
P
S
I
F
A
V
G
D
-----
V
-
A
-
E
----
N
---
V
-
P
E
L
A
P
V
A
I
K
A
G
E
I
L
A
R
R
L
F
K
D
S
D
-
E
---
I
M
D
Y
S
Y
I
P
T
S
I
Y
T
P
I
E
Y
G
A
C
G
Y
S
E
E
K
A
Y
E
L
Y
G
K
S
-
N
V
E
V
F
L
Q
----------------------------TCL-
A
K
L
V
C
L
K
N
E
D
N
R
-
V
I
G
F
H
Y
V
G
P
N
A
G
E
V
T
Q
G
M
A
L
A
L
R
L
K
V
K
K
K
D
F
D
N
C
------------------
113
HHSearch
73.67
34%
-82
* C1 *
1FEC
2
TYTR_CRIFA
A:
[1-470]
-
S
R
A
Y
D
L
V
V
I
G
A
G
S
G
G
-
L
E
A
G
-
W
N
A
A
S
L
H
K
K
R
V
A
V
I
D
---------
L
---------
Q
KHHGPPHYA
A
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
N
Y
M
D
T
I
-
R
E
S
A
--
G
F
G
W
E
L
DR
E
--
S
-
V
R
P
N
W
K
A
L
I
A
A
-------
K
N
K
A
V
S
G
I
N
D
S
Y
E
G
M
F
A
-
D
T
E
G
-
L
T
F
H
Q
G
F
G
A
L
Q
D
---
N
H
--
T
V
----
L
--
V
-----
R
ESADPNSAV
L
E
T
L
D
-----
T
E
Y
-----------
I
L
-----
L
A
T
G
S
W
P
Q
H
L
---
G
I
E
--
G
D
-
D
L
C
I
T
S
N
E
A
F
Y
L
D
E
A
P
K
---------
R
A
L
C
V
G
G
G
Y
I
S
I
E
F
A
G
I
F
N
---
A
-
Y
KAR
G
G
---
Q
V
D
L
A
Y
R
G
D
M
I
L
R
G
F
D
S
E
L
R
K
Q
L
T
E
Q
L
R
A
N
G
I
N
V
R
T
H
E
N
P
A
K
V
T
K
N
A
D
G
T
R
H
--
V
---
V
F
E
S
---
G
------
A
--
E
-----
A
D
------
Y
--------------
D
V
V
M
L
A
I
G
R
V
P
-
R
S
Q
T
-
L
-
Q
L
-
E
K
A
G
V
E
V
A
-
K
N
G
A
-
I
K
V
D
A
Y
S
K
T
N
V
D
N
I
Y
A
I
G
D
-----
V
-
T
-
D
----
R
---
V
-
M
-
L
T
P
V
A
I
N
E
G
A
A
F
V
D
T
V
F
A
N
K
P
-
R
---
A
T
D
H
T
K
V
A
C
A
V
F
S
I
P
P
M
G
V
C
G
Y
V
E
E
D
A
A
K
K
Y
--
D
-
Q
V
A
V
Y
E
S
S
F
--
T
P
-
L
--
M
H
N
I
S
---
G
-
S
T
Y
-
K
K
F
M
----
V
R
I
V
T
N
H
A
D
G
-
E
-
V
L
G
V
H
M
L
G
D
S
S
P
E
I
I
Q
S
V
A
I
C
L
K
M
G
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R
86
PsiBlast_CBE
73.55
36%
-90
- C1 -
2X8H
9
?
A:
[108-581]
----
Y
D
L
I
V
I
G
G
G
S
G
G
-
L
A
A
G
-
K
E
A
A
K
Y
-
G
A
K
T
A
V
L
D
---------
Y
---------
V
---------
E
P
TPI
G
T
T
W
G
-
L
---------
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
D
A
E
H
F
-
G
W
S
L
D
R
--
S
--
K
-
I
S
H
N
W
S
T
M
V
E
G
-------
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
-
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
I
S
---
P
H
--
E
V
----
Q
--
I
-----
T
---------
D
K
N
Q
K
-----
V
S
T
-----------
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
I
P
--
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
A
---
S
-
L
---
G
G
---
D
V
T
V
M
V
R
-
S
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
K
Q
L
K
----
V
--
V
---
D
T
E
N
---
N
------
K
--
P
G
L
---
L
L
------
V
K
G
H
Y
TDG
K
K
F
E
E
E
F
E
T
V
I
F
A
V
G
R
E
P
-
Q
L
-
S
-
K
-
V
L
C
E
T
V
G
V
K
L
D
-
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
D
-----
I
-
N
A
G
----
K
---
P
-
Q
-
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
F
A
G
A
-
T
E
---
L
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
-
D
I
E
V
Y
H
S
N
F
--
K
P
-
L
E
-
W
T
V
A
H
---
R
-
E
-
D
-
N
V
C
Y
----
M
K
L
V
C
R
K
S
D
N
M
R
-
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
---
T
C
S
E
T
F
T
T
L
H
35
PsiBlast_CBE
73.37
36%
-85
- C1 -
2NVK
2
TRXR1_DROME
X:
[8-474]
--
Y
D
Y
D
L
I
V
I
G
G
G
S
A
G
-
L
A
C
A
-
K
E
A
V
L
N
-
G
A
R
V
A
C
L
D
---------
F
---------
V
---------
K
PTPTLGTKWG
V
---------
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
S
L
L
G
E
A
V
H
E
-
A
A
--
A
Y
G
W
N
V
--
D
--
D
K
I
K
P
D
W
H
K
L
V
Q
S
-------
V
Q
N
H
I
K
S
V
N
W
V
T
R
V
D
-
L
-
R
D
K
K
-
V
E
Y
I
N
G
L
G
S
F
V
D
---
S
H
--
T
L
LAKL
K
--
S
-----
G
---------
E
R
T
I
T
-----
A
Q
T
-----------
F
V
-----
I
A
V
G
G
R
P
R
Y
P
---
D
I
P
--
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
D
R
E
P
G
---------
K
T
L
V
V
G
A
G
Y
I
G
L
E
C
A
G
F
L
K
---
G
-
L
---
G
Y
---
E
P
T
V
M
V
R
-
S
I
V
L
R
G
F
D
Q
Q
M
A
E
L
V
A
A
S
M
E
E
R
G
I
P
F
L
R
K
T
V
P
L
S
V
E
K
Q
D
D
G
K
L
L
--
V
---
K
Y
K
N
---
V
------
E
--
T
GEESE
D
V
------
Y
--------------
D
T
V
L
W
A
I
G
R
K
G
-
L
V
-
D
D
L
-
N
L
-
P
N
A
G
V
T
V
Q
--
K
D
K
-
I
P
V
D
S
Q
E
A
T
N
V
A
N
I
Y
A
V
G
D
-----
I
I
Y
-
G
----
K
---
P
-
E
-
L
T
P
V
A
V
L
A
G
R
L
L
A
R
R
L
Y
G
-
G
S
T
Q
---
R
M
D
Y
K
D
V
A
T
T
V
F
T
P
L
E
Y
A
C
V
G
L
S
E
E
D
A
V
K
Q
F
G
A
D
-
E
I
E
V
F
H
G
Y
Y
KP
T
E
-
F
--
F
I
P
Q
K
---
S
-
V
-
R
-
Y
C
Y
L
----
K
A
V
A
E
R
H
G
D
Q
-
R
-
V
Y
G
L
H
Y
I
G
P
V
A
G
E
V
I
Q
G
F
A
A
A
L
K
S
G
L
T
I
N
T
L
I
N
T
V
G
I
H
P
---
T
T
A
E
E
F
T
R
L
A
47
PsiBlast_CBE
73.18
33%
-95
- C1 -
4B1B
1
TRXR_PLAF5
A:
[43-506]
----
Y
D
Y
V
V
I
G
G
G
P
G
G
-
M
A
S
A
-
K
E
A
A
A
H
-
G
A
R
V
L
L
F
D
---------
Y
---------
V
---------
K
P
SSQG
T
K
W
G
-
I
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
H
Y
A
G
H
M
G
S
I
F
K
L
D
S
K
--
A
Y
G
W
K
F
--
D
--
N
-
L
K
H
D
W
K
K
L
V
T
T
-------
V
Q
S
H
I
R
S
L
N
F
S
Y
M
T
G
-
L
-
R
S
S
K
-
V
K
Y
I
N
G
L
A
K
L
K
D
---
K
N
--
T
V
----
S
Y
Y
L
-----
K
-----------
L
S
K
E
E
T
V
T
G
K
Y
-----------
I
L
-----
I
A
T
G
C
R
P
H
I
P
---
D
D
V
EG
A
K
-
E
L
S
I
T
S
D
D
I
F
S
L
K
K
D
P
G
---------
K
T
L
V
V
G
A
S
Y
V
A
L
E
C
S
G
F
L
N
---
S
-
L
---
G
Y
---
D
V
T
V
A
V
R
-
S
I
V
L
R
G
F
D
Q
Q
C
A
V
K
V
K
L
Y
M
E
E
Q
G
V
M
F
K
N
G
I
L
P
K
K
L
T
K
M
D
-
D
K
I
L
--
V
---
E
F
S
D
---
K
------
T
--
S
-----
E
L
------
Y
--------------
D
T
V
L
Y
A
I
G
R
K
G
-
D
I
-
D
G
L
-
N
L
-
E
S
L
N
M
N
V
N
K
S
N
N
K
-
I
I
A
D
H
L
S
C
T
N
I
P
S
I
F
A
V
G
D
-----
V
-
A
-
E
----
N
---
V
-
P
E
L
A
P
V
A
I
K
A
G
E
I
L
A
R
R
L
F
K
D
S
D
-
E
---
I
M
D
Y
S
Y
I
P
T
S
I
Y
T
P
I
E
Y
G
A
C
G
Y
S
E
E
K
A
Y
E
L
Y
G
K
S
-
N
V
E
V
F
L
Q
----------------------------TC
L
-
A
K
L
V
C
L
K
N
E
D
N
R
-
V
I
G
F
H
Y
V
G
P
N
A
G
E
V
T
Q
G
M
A
L
A
L
R
L
K
V
K
K
K
D
F
D
N
C
------------------
36
PsiBlast_CBE
72.64
36%
-81
- C1 -
3DH9
2
TRXR1_DROME
B:
[3-470]
-
S
Y
D
Y
D
L
I
V
I
G
G
G
S
A
G
-
L
A
C
A
-
K
E
A
V
L
N
-
G
A
R
V
A
C
L
D
---------
F
---------
V
---------
K
PTPTLGTKWG
V
---------
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
S
L
L
G
E
A
V
H
E
-
A
A
--
A
Y
G
W
N
V
--
D
--
D
K
I
K
P
D
W
H
K
L
V
Q
S
-------
V
Q
N
H
I
K
S
V
N
W
V
T
R
V
D
-
L
-
R
D
K
K
-
V
E
Y
I
N
G
L
G
S
F
V
D
---
S
H
--
T
L
LAKL
K
--
S
-----
G
---------
E
R
T
I
T
-----
A
Q
T
-----------
F
V
-----
I
A
V
G
G
R
P
R
Y
P
---
D
I
P
--
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
D
R
E
P
G
---------
K
T
L
V
V
G
A
G
Y
I
G
L
E
C
A
G
F
L
K
---
G
-
L
---
G
Y
---
E
P
T
V
M
V
R
-
S
I
V
L
R
G
F
D
Q
Q
M
A
E
L
V
A
A
S
M
E
E
R
G
I
P
F
L
R
K
T
V
P
L
S
V
E
K
Q
D
D
G
K
L
L
--
V
---
K
Y
K
N
---
V
------
E
--
T
GEESE
D
V
------
Y
--------------
D
T
V
L
W
A
I
G
R
K
G
-
L
V
-
D
D
L
-
N
L
-
P
N
A
G
V
T
V
Q
--
K
D
K
-
I
P
V
D
S
Q
E
A
T
N
V
A
N
I
Y
A
V
G
D
-----
I
I
Y
-
G
----
K
---
P
-
E
-
L
T
P
V
A
V
L
A
G
R
L
L
A
R
R
L
Y
G
-
G
S
T
Q
---
R
M
D
Y
K
D
V
A
T
T
V
F
T
P
L
E
Y
A
C
V
G
L
S
E
E
D
A
V
K
Q
F
G
A
D
-
E
I
E
V
F
H
G
Y
Y
KP
T
E
-
F
--
F
I
P
Q
K
---
S
-
V
-
R
-
Y
C
Y
L
----
K
A
V
A
E
R
H
G
D
Q
-
R
-
V
Y
G
L
H
Y
I
G
P
V
A
G
E
V
I
Q
G
F
A
A
A
L
K
S
G
L
T
I
N
T
L
I
N
T
V
G
I
H
P
---
T
T
A
E
E
F
T
R
L
A
40
PsiBlast_CBE
72.60
33%
-96
- C1 -
4J57
2
TRXR2_PLAF7
B:
[42-519]
----
Y
D
Y
V
V
I
G
G
G
P
G
G
-
M
A
S
A
-
K
E
A
A
A
H
-
G
A
R
V
L
L
F
D
---------
Y
---------
V
---------
K
PSSQGTKWG-
I
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
H
Y
A
G
H
M
G
S
I
F
K
L
D
S
K
--
A
Y
G
W
K
F
--
D
--
N
-
L
K
H
D
W
K
K
L
V
T
T
-------
V
Q
S
H
I
R
S
L
N
F
S
Y
M
T
G
-
L
-
R
S
S
K
-
V
K
Y
I
N
G
L
A
K
L
K
D
---
K
N
--
T
V
----
S
YY
L
-----
K
---------
G
D
L
S
K
EETVT
G
K
Y
-----------
I
L
-----
I
A
T
G
C
R
P
H
I
P
---
D
D
V
EG
A
K
-
E
L
S
I
T
S
D
D
I
F
S
L
K
K
D
P
G
---------
K
T
L
V
V
G
A
S
Y
V
A
L
E
C
S
G
F
L
N
---
S
-
L
---
G
Y
---
D
V
T
V
A
V
R
-
S
I
V
L
R
G
F
D
Q
Q
C
A
V
K
V
K
L
Y
M
E
E
Q
G
V
M
F
K
N
G
I
L
P
K
K
L
T
K
M
D
-
D
K
I
L
--
V
---
E
F
S
D
---
K
------
T
--
S
-----
E
L
------
Y
--------------
D
T
V
L
Y
A
I
G
R
K
G
-
D
I
-
D
G
L
-
N
L
-
E
S
L
N
M
N
V
N
K
S
N
N
K
-
I
I
A
D
H
L
S
C
T
N
I
P
S
I
F
A
V
G
D
-----
V
-
A
-
E
----
N
---
V
-
P
E
L
A
P
V
A
I
K
A
G
E
I
L
A
R
R
L
F
K
D
S
D
-
E
---
I
M
D
Y
S
Y
I
P
T
S
I
Y
T
P
I
E
Y
G
A
C
G
Y
S
E
E
K
A
Y
E
L
Y
G
K
S
-
N
V
E
V
F
L
Q
E
F
--
N
N
-
L
--
E
I
S
A
V
---
H
-
R
-------STCL
A
K
L
V
C
L
K
N
E
D
N
R
-
V
I
G
F
H
Y
V
G
P
N
A
G
E
V
T
Q
G
M
A
L
A
L
R
L
K
V
K
K
K
D
F
D
N
C
I
G
I
H
P
---
T
D
A
E
S
F
M
N
L
F
41
PsiBlast_CBE
72.35
33%
-95
- C1 -
4J57
3
TRXR2_PLAF7
A:
[42-519]
----
Y
D
Y
V
V
I
G
G
G
P
G
G
-
M
A
S
A
-
K
E
A
A
A
H
-
G
A
R
V
L
L
F
D
---------
Y
---------
V
---------
K
P
SSQG
T
K
W
G
-
I
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
H
Y
A
G
H
M
G
S
I
F
K
L
D
S
K
--
A
Y
G
W
K
F
--
D
--
N
-
L
K
H
D
W
K
K
L
V
T
T
-------
V
Q
S
H
I
R
S
L
N
F
S
Y
M
T
G
-
L
-
R
S
S
K
-
V
K
Y
I
N
G
L
A
K
L
K
D
---
K
N
--
T
V
----
S
Y
Y
L
-----
K
---------
G
D
L
S
K
E
E
T
V
T
G
K
Y
-----------
I
L
-----
I
A
T
G
C
R
P
H
I
P
---
D
D
V
EG
A
K
-
E
L
S
I
T
S
D
D
I
F
S
L
K
K
D
P
G
---------
K
T
L
V
V
G
A
S
Y
V
A
L
E
C
S
G
F
L
N
---
S
-
L
---
G
Y
---
D
V
T
V
A
V
R
-
S
I
V
L
R
G
F
D
Q
Q
C
A
V
K
V
K
L
Y
M
E
E
Q
G
V
M
F
K
N
G
I
L
P
K
K
L
T
K
M
D
-
D
K
I
L
--
V
---
E
F
S
D
---
K
------
T
--
S
-----
E
L
------
Y
--------------
D
T
V
L
Y
A
I
G
R
K
G
-
D
I
-
D
G
L
-
N
L
-
E
S
L
N
M
N
V
N
K
S
N
N
K
-
I
I
A
D
H
L
S
C
T
N
I
P
S
I
F
A
V
G
D
-----
V
-
A
-
E
----
N
---
V
-
P
E
L
A
P
V
A
I
K
A
G
E
I
L
A
R
R
L
F
K
D
S
D
-
E
---
I
M
D
Y
S
Y
I
P
T
S
I
Y
T
P
I
E
Y
G
A
C
G
Y
S
E
E
K
A
Y
E
L
Y
G
K
S
-
N
V
E
V
F
L
Q
E
F
--
N
N
-
L
--
E
I
S
A
V
---
H
-
R
-------ST
C
L
A
K
L
V
C
L
K
N
E
D
N
R
-
V
I
G
F
H
Y
V
G
P
N
A
G
E
V
T
Q
G
M
A
L
A
L
R
L
K
V
K
K
K
D
F
D
N
C
I
G
I
H
P
---
T
D
A
E
S
F
M
N
L
F
49
PsiBlast_CBE
72.29
34%
-82
- C1 -
2WBA
9
TYTR_TRYBB
A:
[2-472]
-
S
K
A
F
D
L
V
V
I
G
A
G
S
G
G
L
E
A
G
W
-
N
A
A
T
L
Y
-
G
K
R
V
A
V
V
D
---------
V
QTSHGPPFY
A
---------
A
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
H
L
R
E
-
S
A
--
G
F
G
W
E
----------
F
D
G
S
S
V
K
A
N
W
K
K
L
I
A
A
K
N
E
A
V
L
D
I
N
K
S
Y
E
G
M
-
F
N
D
T
E
G
-
L
D
F
F
L
G
W
G
S
L
E
S
---
K
N
--
V
V
----
V
--
V
-----
R
ETADPKSAV
K
E
R
L
Q
-----
A
D
H
-----------
I
L
-----
L
A
T
G
S
W
P
Q
M
P
---
A
I
P
--
G
I
-
E
H
C
I
S
S
N
E
A
F
Y
L
P
E
P
P
R
---------
R
V
L
T
V
G
G
G
F
I
S
V
E
F
A
G
I
F
N
---
A
-
Y
KPP
G
G
---
K
V
T
L
C
Y
R
N
N
L
I
L
R
G
F
D
E
T
I
R
E
E
V
T
K
Q
L
T
A
N
G
I
E
I
M
T
N
E
N
P
A
K
V
S
L
N
T
D
G
S
K
H
--
V
---
T
F
E
S
---
G
------
K
--
T
-----
L
D
------
V
--------------
D
V
V
M
M
A
I
G
R
I
P
-
R
T
N
D
-
L
-
Q
L
-
G
N
V
G
V
K
L
T
-
P
K
G
G
-
V
Q
V
D
E
F
S
R
T
N
V
P
N
I
Y
A
I
G
D
-----
I
-
T
-
D
----
R
---
L
-
M
-
L
T
P
V
A
I
N
E
G
A
A
L
V
D
T
V
F
G
N
K
P
-
R
---
K
T
D
H
T
R
V
A
S
A
V
F
S
I
P
P
I
G
T
C
G
L
I
E
E
V
A
A
K
E
F
--
E
-
K
V
A
V
Y
M
S
S
F
--
T
P
-
L
--
M
H
N
I
S
---
G
-
S
-
K
Y
K
K
F
V
----
A
K
I
V
T
N
H
S
D
G
-
T
-
V
L
G
V
H
L
L
G
D
G
A
P
E
I
I
Q
A
V
G
V
C
L
R
L
N
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R
98
PsiBlast_CBE
72.15
33%
-78
- C1 -
1GXF
6
TYTR_TRYCR
A:
[4-472]
--
K
I
F
D
L
V
V
I
G
A
G
S
G
G
-
L
E
A
A
W
N
A
A
T
L
Y
-
K
K
R
V
A
V
I
D
---------
V
---------
Q
---------
M
----------
V
HGPPFFSAL
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
E
H
L
R
E
-
S
A
--
G
F
G
W
E
----------
F
D
R
T
T
L
R
A
E
W
K
N
L
I
A
V
K
D
E
A
V
L
N
I
N
K
S
Y
D
E
M
-
F
R
D
T
E
G
-
L
E
F
F
L
G
W
G
S
L
E
S
---
K
N
--
V
V
----
N
--
V
-----
R
ESADPASAV
K
E
R
L
E
-----
T
E
H
-----------
I
L
-----
L
A
S
G
S
W
P
H
M
P
---
N
I
P
--
G
I
-
E
H
C
I
S
S
N
E
A
F
Y
L
P
E
P
P
R
---------
R
V
L
T
V
G
G
G
F
I
S
V
E
F
A
G
I
F
N
---
A
-
Y
---
K
P
KD
G
Q
V
T
L
C
Y
R
G
E
M
I
L
R
G
F
D
H
T
L
R
E
E
L
T
K
Q
L
T
A
N
G
I
Q
I
L
T
K
E
N
P
A
K
V
E
L
N
A
D
G
S
K
S
--
V
---
T
F
E
S
---
G
------
K
--
K
-----
M
D
------
F
--------------
D
L
V
M
M
A
I
G
R
S
P
-
R
T
K
D
-
L
-
Q
L
-
Q
N
A
G
V
M
I
K
-
N
G
G
--
V
Q
V
D
E
Y
S
R
T
N
V
S
N
I
Y
A
I
G
D
-----
V
-
T
-
N
----
R
---
V
-
M
-
L
T
P
V
A
I
N
E
A
A
A
L
V
D
T
V
F
G
T
T
P
-
R
---
K
T
D
H
T
R
V
A
S
A
V
F
S
I
P
P
I
G
T
C
G
L
I
E
E
V
A
S
K
R
Y
--
E
-
V
V
A
V
Y
L
S
S
F
--
T
P
-
L
--
M
H
K
V
S
---
G
-
S
-
K
Y
K
T
F
V
----
A
K
I
I
T
N
H
S
D
G
-
T
-
V
L
G
V
H
L
L
G
D
N
A
P
E
I
I
Q
G
I
G
I
C
L
K
L
N
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R
87
PsiBlast_CBE
72.05
36%
-89
- C1 -
2X8G
7
?
A:
[108-581]
----
Y
D
L
I
V
I
G
G
G
S
G
G
-
L
A
A
G
-
K
E
A
A
K
Y
-
G
A
K
T
A
V
L
D
---------
Y
---------
V
---------
E
P
TPI
G
T
T
W
G
-
L
---------
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
D
A
E
H
F
-
G
W
S
L
D
R
--
S
--
K
-
I
S
H
N
W
S
T
M
V
E
G
-------
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
-
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
I
S
---
P
H
--
E
V
----
Q
--
I
-----
T
---------
D
K
N
Q
K
-----
V
S
T
-----------
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
I
P
--
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
A
---
S
-
L
---
G
G
---
D
V
T
V
M
V
R
-
S
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
K
Q
L
K
----
V
--
V
---
D
T
E
N
---
N
------
K
--
P
G
L
---
L
L
------
V
K
G
H
Y
TDG
K
K
F
E
E
E
F
E
T
V
I
F
A
V
G
R
E
P
-
Q
L
-
S
-
K
-
V
L
C
E
T
V
G
V
K
L
D
-
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
D
-----
I
-
N
A
G
----
K
---
P
-
Q
-
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
F
A
G
A
-
T
E
---
L
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
-
D
I
E
V
Y
H
S
N
F
--
K
P
-
L
E
-
W
T
V
A
H
---
R
-
E
-
D
-
N
V
C
Y
----
M
K
L
V
C
R
K
S
D
N
M
R
-
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
---
T
C
S
E
T
F
T
T
L
H
90
PsiBlast_CBE
71.93
36%
-87
- C1 -
3H4K
6
?
A:
[108-581]
----
Y
D
L
I
V
I
G
G
G
S
G
G
-
L
A
A
G
-
K
E
A
A
K
Y
-
G
A
K
T
A
V
L
D
---------
Y
---------
V
---------
E
P
TPIG
T
T
W
G
-
L
---------
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
D
A
E
H
F
-
G
W
S
L
D
R
--
S
--
K
-
I
S
H
N
W
S
T
M
V
E
G
-------
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
-
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
I
S
---
P
H
--
E
V
----
Q
--
I
-----
T
---------
D
K
N
Q
K
-----
V
S
T
-----------
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
I
P
--
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
A
---
S
-
L
---
G
G
---
D
V
T
V
M
V
R
-
S
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
K
Q
L
K
----
V
--
V
---
D
T
E
N
---
N
------
K
--
P
G
L
---
L
L
------
V
K
G
H
Y
TDG
K
K
F
E
E
E
F
E
T
V
I
F
A
V
G
R
E
P
-
Q
L
-
S
-
K
-
V
L
C
E
T
V
G
V
K
L
D
-
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
D
-----
I
-
N
A
G
----
K
---
P
-
Q
-
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
F
A
G
A
-
T
E
---
L
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
-
D
I
E
V
Y
H
S
N
F
--
K
P
-
L
E
-
W
T
V
A
H
---
R
-
E
-
D
-
N
V
C
Y
----
M
K
L
V
C
R
K
S
D
N
M
R
-
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
---
T
C
S
E
T
F
T
T
L
H
97
PsiBlast_CBE
71.28
33%
-80
- C1 -
1GXF
5
TYTR_TRYCR
B:
[5-472]
---
I
F
D
L
V
V
I
G
A
G
S
G
G
-
L
E
A
A
W
N
A
A
T
L
Y
-
K
K
R
V
A
V
I
D
---------
V
---------
Q
---------
M
----------
V
HGPPFFSAL
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
E
H
L
R
E
-
S
A
--
G
F
G
W
E
----------
F
D
R
T
T
L
R
A
E
W
K
N
L
I
A
V
K
D
E
A
V
L
N
I
N
K
S
Y
D
E
M
-
F
R
D
T
E
G
-
L
E
F
F
L
G
W
G
S
L
E
S
---
K
N
--
V
V
----
N
--
V
-----
R
ESADPASAV
K
E
R
L
E
-----
T
E
H
-----------
I
L
-----
L
A
S
G
S
W
P
H
M
P
---
N
I
P
--
G
I
-
E
H
C
I
S
S
N
E
A
F
Y
L
P
E
P
P
R
---------
R
V
L
T
V
G
G
G
F
I
S
V
E
F
A
G
I
F
N
---
A
-
Y
---
K
P
KD
G
Q
V
T
L
C
Y
R
G
E
M
I
L
R
G
F
D
H
T
L
R
E
E
L
T
K
Q
L
T
A
N
G
I
Q
I
L
T
K
E
N
P
A
K
V
E
L
N
A
D
G
S
K
S
--
V
---
T
F
E
S
---
G
------
K
--
K
-----
M
D
------
F
--------------
D
L
V
M
M
A
I
G
R
S
P
-
R
T
K
D
-
L
-
Q
L
-
Q
N
A
G
V
M
I
K
-
N
G
G
--
V
Q
V
D
E
Y
S
R
T
N
V
S
N
I
Y
A
I
G
D
-----
V
-
T
-
N
----
R
---
V
-
M
-
L
T
P
V
A
I
N
E
A
A
A
L
V
D
T
V
F
G
T
T
P
-
R
---
K
T
D
H
T
R
V
A
S
A
V
F
S
I
P
P
I
G
T
C
G
L
I
E
E
V
A
S
K
R
Y
--
E
-
V
V
A
V
Y
L
S
S
F
--
T
P
-
L
--
M
H
K
V
S
---
G
-
S
-
K
Y
K
T
F
V
----
A
K
I
I
T
N
H
S
D
G
-
T
-
V
L
G
V
H
L
L
G
D
N
A
P
E
I
I
Q
G
I
G
I
C
L
K
L
N
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R
85
PsiBlast_CBE
71.09
36%
-85
- C1 -
2X99
13
?
A:
[108-581]
----
Y
D
L
I
V
I
G
G
G
S
G
G
-
L
A
A
G
-
K
E
A
A
K
Y
-
G
A
K
T
A
V
L
D
---------
Y
---------
V
---------
E
P
TPI
G
T
T
W
G
-
L
---------
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
D
A
E
H
F
-
G
W
S
L
D
R
--
S
--
K
-
I
S
H
N
W
S
T
M
V
E
G
-------
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
-
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
I
S
---
P
H
--
E
V
----
Q
--
I
-----
T
---------
D
K
N
Q
K
-----
V
S
T
-----------
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
I
P
--
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
A
---
S
-
L
---
G
G
---
D
V
T
V
M
V
R
-
S
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
K
Q
L
K
----
V
--
V
---
D
T
E
N
---
N
------
K
--
P
G
L
---
L
L
------
V
K
G
H
Y
TDG
K
K
F
E
E
E
F
E
T
V
I
F
A
V
G
R
E
P
-
Q
L
-
S
-
K
-
V
L
C
E
T
V
G
V
K
L
D
-
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
D
-----
I
-
N
A
G
----
K
---
P
-
Q
-
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
F
A
G
A
-
T
E
---
L
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
-
D
I
E
V
Y
H
S
N
F
--
K
P
-
L
E
-
W
T
V
A
H
---
R
-
E
-
D
-
N
V
C
Y
----
M
K
L
V
C
R
K
S
D
N
M
R
-
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
---
T
C
S
E
T
F
T
T
L
H
94
PsiBlast_CBE
70.96
35%
-79
- C1 -
1ZDL
2
TRXR2_MOUSE
A:
[31-500]
--
Q
S
F
D
L
L
V
I
G
G
G
S
G
G
-
L
A
C
A
-
K
E
A
A
Q
L
-
G
K
K
V
A
V
A
D
---------
Y
---------
V
---------
E
PSPRG
T
K
W
G
-
L
---------
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
A
L
L
G
G
M
I
-
R
D
A
H
--
H
Y
G
W
E
V
A-
Q
--
P
-
V
Q
H
N
W
K
T
M
A
E
A
-------
V
Q
N
H
V
K
S
L
N
W
G
H
R
V
Q
-
L
-
Q
D
R
K
-
V
K
Y
F
N
I
K
A
S
F
V
D
---
E
H
--
T
V
----
R
--
G
V
D
KG
G
K
---------
A
T
L
L
S
-----
A
E
H
-----------
I
V
-----
I
A
T
G
G
R
P
R
Y
P
---
T
Q
V
KG
A
L
-
E
Y
G
I
T
S
D
D
I
F
W
L
K
E
S
P
G
---------
K
T
L
V
V
G
A
S
Y
V
A
L
E
C
A
G
F
L
T
---
G
-
I
---
G
L
---
D
T
T
V
M
M
R
S
I
P
-
L
R
G
F
D
Q
Q
M
S
S
L
V
T
E
H
M
E
S
H
G
T
Q
F
L
K
G
C
V
P
S
H
I
K
K
L
P
T
N
Q
L
Q
--
V
---
T
W
E
D
HAS
G
------
K
E
D
T
-----
G
T
------
F
--------------
D
T
V
L
W
A
I
G
R
V
P
-
E
T
R
T
-
L
-
N
L
-
E
K
A
G
I
S
T
N
-
P
K
N
Q
K
I
I
V
D
A
Q
E
A
T
S
V
P
H
I
Y
A
I
G
D
-----
V
A
E
-
G
----
R
---
P
-
E
-
L
T
P
T
A
I
K
A
G
K
L
L
A
Q
R
L
F
G
-
K
S
S
T
---
L
M
D
Y
S
N
V
P
T
T
V
F
T
P
L
E
Y
G
C
V
G
L
S
E
E
E
A
V
A
L
H
G
Q
E
-
H
V
E
V
Y
H
A
Y
Y
--
K
P
-
L
E
-
F
T
V
A
D
---
R
-
D
-
A
-
S
Q
C
Y
----
I
K
M
V
C
M
R
E
P
P
-
Q
L
V
L
G
L
H
F
L
G
P
N
A
G
E
V
T
Q
G
F
A
L
G
I
K
C
G
A
S
Y
A
Q
V
M
Q
T
V
G
I
H
P
---
T
C
S
E
E
V
V
K
L
H
84
PsiBlast_CBE
70.93
36%
-88
- C1 -
2V6O
6
?
A:
[108-581]
----
Y
D
L
I
V
I
G
G
G
S
G
G
-
L
A
A
G
-
K
E
A
A
K
Y
-
G
A
K
T
A
V
L
D
---------
Y
---------
V
---------
E
P
TPI
G
T
T
W
G
-
L
---------
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
D
A
E
H
F
-
G
W
S
L
D
R
--
S
--
K
-
I
S
H
N
W
S
T
M
V
E
G
-------
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
-
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
I
S
---
P
H
--
E
V
----
Q
--
I
-----
T
---------
D
K
N
Q
K
-----
V
S
T
-----------
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
I
P
--
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
A
---
S
-
L
---
G
G
---
D
V
T
V
M
V
R
-
S
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
K
Q
L
K
----
V
--
V
---
D
T
E
N
---
N
------
K
--
P
G
L
---
L
L
------
V
K
G
H
Y
TDG
K
K
F
E
E
E
F
E
T
V
I
F
A
V
G
R
E
P
-
Q
L
-
S
-
K
-
V
L
C
E
T
V
G
V
K
L
D
-
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
D
-----
I
-
N
A
G
----
K
---
P
-
Q
-
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
F
A
G
A
-
T
E
---
L
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
-
D
I
E
V
Y
H
S
N
F
--
K
P
-
L
E
-
W
T
V
A
H
---
R
-
E
-
D
-
N
V
C
Y
----
M
K
L
V
C
R
K
S
D
N
M
R
-
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
---
T
C
S
E
T
F
T
T
L
H
48
PsiBlast_CBE
70.78
34%
-80
- C1 -
2WBA
8
TYTR_TRYBB
B:
[2-472]
-
S
K
A
F
D
L
V
V
I
G
A
G
S
G
G
L
E
A
G
W
-
N
A
A
T
L
Y
-
G
K
R
V
A
V
V
D
---------
V
QTSHGPPFY
A
---------
A
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
H
L
R
E
-
S
A
--
G
F
G
W
E
----------
F
D
G
S
S
V
K
A
N
WKKLIAA
K
N
E
A
V
L
D
I
N
K
S
Y
E
G
M
-
F
N
D
T
E
G
-
L
D
F
F
L
G
W
G
S
L
E
S
---
K
N
--
V
V
----
V
--
V
-----
R
ETADPKSAV
K
E
R
L
Q
-----
A
D
H
-----------
I
L
-----
L
A
T
G
S
W
P
Q
M
P
---
A
I
P
--
G
I
-
E
H
C
I
S
S
N
E
A
F
Y
L
P
E
P
P
R
---------
R
V
L
T
V
G
G
G
F
I
S
V
E
F
A
G
I
F
N
---
A
-
Y
KPP
G
G
---
K
V
T
L
C
Y
R
N
N
L
I
L
R
G
F
D
E
T
I
R
E
E
V
T
K
Q
L
T
A
N
G
I
E
I
M
T
N
E
N
P
A
K
V
S
L
N
T
D
G
S
K
H
--
V
---
T
F
E
S
---
G
------
K
--
T
-----
L
D
------
V
--------------
D
V
V
M
M
A
I
G
R
I
P
-
R
T
N
D
-
L
-
Q
L
-
G
N
V
G
V
K
L
T
-
P
K
G
G
-
V
Q
V
D
E
F
S
R
T
N
V
P
N
I
Y
A
I
G
D
-----
I
-
T
-
D
----
R
---
L
-
M
-
L
T
P
V
A
I
N
E
G
A
A
L
V
D
T
V
F
G
N
K
P
-
R
---
K
T
D
H
T
R
V
A
S
A
V
F
S
I
P
P
I
G
T
C
G
L
I
E
E
V
A
A
K
E
F
--
E
-
K
V
A
V
Y
M
S
S
F
--
T
P
-
L
--
M
H
N
I
S
---
G
-
S
-
K
Y
K
K
F
V
----
A
K
I
V
T
N
H
S
D
G
-
T
-
V
L
G
V
H
L
L
G
D
G
A
P
E
I
I
Q
A
V
G
V
C
L
R
L
N
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R
37
PsiBlast_CBE
70.75
36%
-82
- C1 -
3DH9
2
TRXR1_DROME
A:
[3-470]
-
S
Y
D
Y
D
L
I
V
I
G
G
G
S
A
G
-
L
A
C
A
-
K
E
A
V
L
N
-
G
A
R
V
A
C
L
D
---------
F
---------
V
---------
K
P
TPTLG
T
K
W
G
V
---------
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
S
L
L
G
E
A
V
H
E
-
A
A
--
A
Y
G
W
N
V
--
D
--
D
K
I
K
P
D
W
H
K
L
V
Q
S
-------
V
Q
N
H
I
K
S
V
N
W
V
T
R
V
D
-
L
-
R
D
K
K
-
V
E
Y
I
N
G
L
G
S
F
V
D
---
S
H
--
T
L
L
A
K
L
K
--
S
-----
G
---------
E
R
T
I
T
-----
A
Q
T
-----------
F
V
-----
I
A
V
G
G
R
P
R
Y
P
---
D
I
P
--
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
D
R
E
P
G
---------
K
T
L
V
V
G
A
G
Y
I
G
L
E
C
A
G
F
L
K
---
G
-
L
---
G
Y
---
E
P
T
V
M
V
R
-
S
I
V
L
R
G
F
D
Q
Q
M
A
E
L
V
A
A
S
M
E
E
R
G
I
P
F
L
R
K
T
V
P
L
S
V
E
K
Q
D
D
G
K
L
L
--
V
---
K
Y
K
N
---
V
------
E
--
T
G
E
E
S
E
D
V
------
Y
--------------
D
T
V
L
W
A
I
G
R
K
G
-
L
V
-
D
D
L
-
N
L
-
P
N
A
G
V
T
V
Q
--
K
D
K
-
I
P
V
D
S
Q
E
A
T
N
V
A
N
I
Y
A
V
G
D
-----
I
I
Y
-
G
----
K
---
P
-
E
-
L
T
P
V
A
V
L
A
G
R
L
L
A
R
R
L
Y
G
-
G
S
T
Q
---
R
M
D
Y
K
D
V
A
T
T
V
F
T
P
L
E
Y
A
C
V
G
L
S
E
E
D
A
V
K
Q
F
G
A
D
-
E
I
E
V
F
H
G
Y
Y
K
P
T
E
-
F
--
F
I
P
Q
K
---
S
-
V
-
R
-
Y
C
Y
L
----
K
A
V
A
E
R
H
G
D
Q
-
R
-
V
Y
G
L
H
Y
I
G
P
V
A
G
E
V
I
Q
G
F
A
A
A
L
K
S
G
L
T
I
N
T
L
I
N
T
V
G
I
H
P
---
T
T
A
E
E
F
T
R
L
A
104
HHSearch
70.54
36%
-87
- C1 -
3O0H
4
?
A:
[24-470]
-
S
F
D
F
D
L
F
V
I
G
S
G
S
G
G
-
V
R
A
A
-
R
L
A
G
A
L
-
G
K
R
V
A
I
A
E
---------
E
---------
Y
---------
R
----------
I
---------
G
G
T
C
V
I
R
G
C
V
P
K
K
L
Y
F
Y
A
S
Q
Y
A
Q
E
F
-
S
K
S
I
--
G
F
G
W
K
Y
--
A
--
D
-
P
I
F
N
W
E
K
L
V
A
A
-------
K
N
K
E
I
S
R
L
E
G
L
Y
R
E
G
-
L
-
Q
N
S
N
-
V
H
I
Y
E
S
R
A
V
F
V
D
---
E
H
--
T
L
----
E
--
L
SV---
T
---------
G
E
R
I
S
-----
A
E
K
-----------
I
L
-----
I
A
T
G
A
K
I
V
S
N
----
I
K
--
G
S
-
D
L
C
L
T
S
N
E
I
F
D
L
E
K
L
P
K
---------
S
I
V
I
V
G
G
G
Y
I
G
V
E
F
A
N
I
F
H
---
G
-
L
---
G
V
---
K
T
T
L
L
H
R
G
D
L
I
L
R
N
F
D
Y
D
L
R
Q
L
L
N
D
A
M
V
A
K
G
I
S
I
I
Y
E
A
T
V
S
Q
V
Q
S
T
E
N
C
-
Y
N
--
V
---
V
L
T
N
---
G
------
Q
--
T
-----
I
C
------
A
--------------
D
R
V
M
L
A
T
G
R
V
P
-
N
T
T
G
-
L
-
G
L
-
E
R
A
G
V
K
V
N
-
E
F
G
A
-
V
V
V
D
E
K
M
T
T
N
V
S
H
I
W
A
V
G
D
-----
V
-
T
-
G
----
H
---
I
-
Q
-
L
T
P
V
A
I
H
D
A
M
C
F
V
K
N
A
F
E
----
T
---
T
P
D
Y
D
L
I
T
T
A
V
F
S
Q
P
E
I
G
T
V
G
L
S
E
E
D
A
L
H
R
--
Y
K
-
R
V
E
I
Y
R
T
V
F
--
R
P
-
M
--
R
N
V
L
S
---
G
-
S
-
P
-
E
K
M
F
----
M
K
L
V
V
D
G
E
S
R
-
I
-
V
V
G
A
H
V
L
G
E
N
A
G
E
I
A
Q
L
I
G
I
S
L
K
G
K
L
T
K
D
I
F
D
K
T
M
A
V
H
P
---
T
M
S
E
E
L
V
T
M
Y
89
PsiBlast_CBE
69.81
36%
-90
- C1 -
2X8C
5
?
A:
[108-581]
----
Y
D
L
I
V
I
G
G
G
S
G
G
-
L
A
A
G
-
K
E
A
A
K
Y
-
G
A
K
T
A
V
L
D
---------
Y
---------
V
---------
E
P
T
PI
G
T
T
W
G
-
L
---------
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
D
A
E
H
F
-
G
W
S
L
D
R
--
S
--
K
-
I
S
H
N
W
S
T
M
V
E
G
-------
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
-
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
I
S
---
P
H
--
E
V
----
Q
--
I
-----
T
---------
D
K
N
Q
K
-----
V
S
T
-----------
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
I
P
--
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
A
---
S
-
L
---
G
G
---
D
V
T
V
M
V
R
-
S
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
K
Q
L
K
----
V
--
V
---
D
T
E
N
---
N
------
K
--
P
G
L
---
L
L
------
V
K
G
H
Y
TDG
K
K
F
E
E
E
F
E
T
V
I
F
A
V
G
R
E
P
-
Q
L
-
S
-
K
-
V
L
C
E
T
V
G
V
K
L
D
-
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
D
-----
I
-
N
A
G
----
K
---
P
-
Q
-
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
F
A
G
A
-
T
E
---
L
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
-
D
I
E
V
Y
H
S
N
F
--
K
P
-
L
E
-
W
T
V
A
H
---
R
-
E
-
D
-
N
V
C
Y
----
M
K
L
V
C
R
K
S
D
N
M
R
-
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
---
T
C
S
E
T
F
T
T
L
H
99
PsiBlast_CBE
69.42
33%
-82
- C1 -
2X50
8
?
B:
[22-492]
-
S
R
A
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
-
N
A
A
V
T
H
-
K
K
K
V
A
V
V
D
VQATHGPPL
F
---------
A
---------
A
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
-
L
I
R
E
S
G
--
G
F
G
W
E
M
--
D
RE
S
-
L
C
P
N
W
K
T
L
I
A
A
-------
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
-
F
A
D
T
E
G
-
L
S
F
H
M
G
F
G
A
L
Q
D
---
A
H
--
T
V
----
V
--
V
----------------
R
K
S
E
-----
D
P
H
SDVLETLDTEY
I
L
-----
I
A
T
G
S
W
P
T
R
L
---
G
V
P
--
G
D
-
E
F
C
I
T
S
N
E
A
F
Y
L
E
D
A
P
K
---------
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
GYK
P
-
C
---
G
G
---
Y
V
D
L
C
Y
R
G
D
L
I
L
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
N
G
I
R
V
R
T
N
L
N
P
T
K
I
T
K
N
E
D
G
S
N
H
--
V
---
H
F
N
D
---
G
------
T
--
E
-----
E
D
------
Y
--------------
D
Q
V
M
L
A
I
G
R
V
P
-
R
S
-
Q
A
L
-
Q
L
-
D
K
A
G
V
R
T
G
-
K
N
G
A
-
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
D
-----
V
-
T
-
N
----
R
---
V
-
M
-
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
F
G
G
K
P
-
R
---
A
T
D
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
Y
--
E
-
T
V
A
V
Y
A
S
S
F
--
T
P
L
M
--
H
N
I
S
G
---
S
-
K
-
H
-
K
E
F
M
----
I
R
I
I
T
N
E
S
N
G
-
E
-
V
L
G
V
H
M
L
G
D
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R
91
PsiBlast_CBE
69.38
35%
-85
- C1 -
3O0H
4
?
A:
[24-469]
-
S
F
D
F
D
L
F
V
I
G
S
G
S
G
G
-
V
R
A
A
-
R
L
A
G
A
L
-
G
K
R
V
A
I
A
E
---------
E
---------
Y
---------
R
----------
I
---------
G
G
T
C
V
I
R
G
C
V
P
K
K
L
Y
F
Y
A
S
Q
Y
A
Q
E
F
S
K
-
S
I
--
G
F
G
W
K
Y
--
A
--
D
-
P
I
F
N
W
E
K
L
V
A
A
-------
K
N
K
E
I
S
R
L
E
G
L
Y
R
E
G
-
L
-
Q
N
S
N
-
V
H
I
Y
E
S
R
A
V
F
V
D
---
E
H
--
T
L
----
E
L
S
V
-----
T
---------
G
E
R
I
S
-----
A
E
K
-----------
I
L
-----
I
A
T
G
A
K
I
V
S
N
-----
I
K-
G
S
-
D
L
C
L
T
S
N
E
I
F
D
L
E
K
L
P
K
---------
S
I
V
I
V
G
G
G
Y
I
G
V
E
F
A
N
I
F
H
---
G
-
L
---
G
V
---
K
T
T
L
L
H
R
G
D
L
I
L
R
N
F
D
Y
D
L
R
Q
L
L
N
D
A
M
V
A
K
G
I
S
I
I
Y
E
A
T
V
S
Q
V
Q
S
T
E
N
C
Y
N
V
--
V
----
L
T
N
---
G
------
Q
--
T
-----
I
C
------
A
--------------
D
R
V
M
L
A
T
G
R
V
P
-
N
T
-
T
G
L
-
G
L
-
E
R
A
G
V
K
V
N
-
E
F
G
A
-
V
V
V
D
E
K
M
T
T
N
V
S
H
I
W
A
V
G
D
-----
V
-
T
-
G
----
H
---
I
-
Q
-
L
T
P
V
A
I
H
D
A
M
C
F
V
K
N
A
F
E
---
T
T
---
P
-
D
Y
D
L
I
T
T
A
V
F
S
Q
P
E
I
G
T
V
G
L
S
E
E
D
A
L
H
R
Y
--
K
-
R
V
E
I
Y
R
T
V
F
--
R
P
-
M
--
R
N
V
L
S
---
G
-
S
-
P
-
E
K
M
F
----
M
K
L
V
V
D
G
E
S
R
-
I
-
V
V
G
A
H
V
L
G
E
N
A
G
E
I
A
Q
L
I
G
I
S
L
K
G
K
L
T
K
D
I
F
D
K
T
M
A
V
H
P
---
T
M
S
E
E
L
V
T
M
Y
100
PsiBlast_CBE
68.00
33%
-82
- C1 -
2X50
8
?
A:
[22-492]
-
S
R
A
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
-
N
A
A
V
T
H
-
K
K
K
V
A
V
V
D
VQA
T
H
G
P
PL
F
---------
A
---------
A
----------
L
---------
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
-
L
I
R
E
S
G
--
G
F
G
W
E
M
--
D
RE
S
-
L
C
P
N
W
K
T
L
I
A
A
-------
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
-
F
A
D
T
E
G
-
L
S
F
H
M
G
F
G
A
L
Q
D
---
A
H
--
T
V
----
V
--
V
----------------
R
K
S
E
-----
D
P
H
SDVL
E
T
L
D
T
E
Y
I
L
-----
I
A
T
G
S
W
P
T
R
L
---
G
V
P
--
G
D
-
E
F
C
I
T
S
N
E
A
F
Y
L
E
D
A
P
K
---------
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
Y
K
P
-
C
---
G
G
---
Y
V
D
L
C
Y
R
G
D
L
I
L
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
N
G
I
R
V
R
T
N
L
N
P
T
K
I
T
K
N
E
D
G
S
N
H
--
V
---
H
F
N
D
---
G
------
T
--
E
-----
E
D
------
Y
--------------
D
Q
V
M
L
A
I
G
R
V
P
-
R
S
-
Q
A
L
-
Q
L
-
D
K
A
G
V
R
T
G
-
K
N
G
A
-
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
D
-----
V
-
T
-
N
----
R
---
V
-
M
-
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
F
G
G
K
P
-
R
---
A
T
D
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
Y
--
E
-
T
V
A
V
Y
A
S
S
F
--
T
P
L
M
--
H
N
I
S
G
---
S
-
K
-
H
-
K
E
F
M
----
I
R
I
I
T
N
E
S
N
G
-
E
-
V
L
G
V
H
M
L
G
D
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
---
T
S
A
E
E
L
C
S
M
R