@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1477: (2015-12-08 )
MKKINKCLTVFSTLLLILTSLFSVAPAFADDVTTDTVTLHKIVMPQAAFDNFTEGTKGKNDSDYVGKQINDLKSYFGSTDAKEIKGAFFVFKNETGTKFITENGKEVDTLEAKDAEGGAVLSGLTKDTGFAFNTAKLKGTYQIVELKEKSNYDNNGSILADSKAVPVKITLPLVNNQGVVKDAHIYPKNTETKPQVDKNFADKDLDYTDNRKDKGVVSATVGDKKEYIVGTKILKGSDYKKLVWTDSMTKGLTFNNNVKVTLDGKDFPVLNYKLVTDDQGFRLALNATGLAAVAAAAKDKDVEIKITYSATVNGSTTVEVPETNDVKLDYGNNPTEESEPQEGTPANQEIKVIKDWAVDGTITDVNVAVKAIFTLQEKQTDGTWVNVASHEATKPSRFEHTFTGLDNTKTYRVVERVSGYTPEYVSFKNGVVTIKNNKNSNDPTPINPSEPKVVTYGRKFVKTNQANTERLAGATFLVKKEGKYLARKAGAATAEAKAAVKTAKLALDEAVKAYNDLTKEKQEGQEGKTALATVDQKQKAYNDAFVKANYSYEWVADKKADNVVKLISNAGGQFEITGLDKGTYSLEETQAPAGYATLSGDVNFEVTATSYSKGATTDIAYDKGSVKKDAQQVQNKKVTIPQTGGIGTILFTIIGLSIMLGAVVVMKKRQSEEA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100....----.------.---.110..-.----.-.--..120.......130......-..140........150-.-......160.......170...---....--180.......190.......200...---....210.......220.......230...---..-----.-.240.......250.....-....--260....----..-----.270....----...280--.......290.....------------------.--.300.------------------......310.......320.......330.......340...-.-..-.350.......360---------..--......370.......380.......390......-------------------.400....---------...410....-...420......-.-430.......440.......-450.......460....---.-..470....-..---.480--..---.---.-.-...490.......500.......510.......520.......530.......540.......550......-.-560........570.......580--------------.--------------------.......590.---------......600.......610.....-..620.......630.......640.......650.......660.......670..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
K
I
N
K
C
L
T
V
F
S
T
L
L
L
I
L
T
S
L
F
S
VA
P
A
FADDVTTD
T
V
T
L
H
K
IVMP
Q
A
AFDNFTEGTKGKN
D
S
D
Y
V
G
K
Q
I
N
D
L
K
S
Y
FGST
D
A
K
EI
K
G
A
F
F
V
F
KNETG
T
K
F
ITENGKE----V------D---
T
L
EAKD-A----E-G--
G
A
V
L
SGLTKDTG
F
-
A
F
N
T
A
KL-K
G
T
-
Y
Q
I
V
E
L
KEKSNY-D-NNG
S
I
L
ADS
K
A
V
P
V
K
I
T
L
P
LVN---NQG
V
--
V
KDAHIYPKNTETKPQVDKNFADKDL---DYTDNRKDK
G
V
V
S
A
TVGDKK
E
Y
I
V
G
T
K
ILK---GS-----D-Y
K
K
L
V
WTDSMTK--G
L
T
FN-N
N
V
K
--
V
T
LDGKD----
F
P
-----
V
L
N
Y
K
L
VT----DDQ
G
F
R
--
L
A
LNAT
G
L
A
A
V
A
AAA------------------K--DK
D
V
E
------------------
I
K
I
T
Y
S
A
TVNG
S
T
T
V
EVPETN
D
V
K
L
DYGNNPTEESEPQEGTP-A-N
Q
-
E
I
K
V
I
K
DWAVDG
T
----------
I
T
--
D
V
N
V
A
V
K
A
I
F
T
L
Q
EKQTDG
T
W
V
N
VASHEATKPSR
F
-------------------
E
H
T
FTGLD---------N
T
K
T
Y
R
V
V
E
R
-VSGYTP
E
Y
V
S
FK-N-
G
V
V
T
I
KNNKNSNDPTPINPS-EP
K
V
V
TYG
R
K
F
V
KTNQA---
N
-
T
E
RLA
G
A
T
F
-
L
V
---KKE---G
K
---
Y
---
L
-
A
-
R
KAGAAT
A
E
A
K
A
A
V
K
T
A
K
L
A
L
D
E
A
V
K
A
Y
N
D
L
T
K
E
K
QEGQEGK
T
A
L
A
T
V
D
Q
K
Q
K
AYN
D
A
F
V
K
ANY
S
Y
E
W
VADK-K-A-
D
N
V
V
K
L
I
S
NAGG
Q
F
E
I
T
GLDK---------------G--------------------TYSLEETQAPA---------G
Y
A
T
LSGD
V
N
F
E
V
T
ATSYSKGATT-
D
I
AYDKGS
V
K
K
D
A
Q
Q
VQNK
K
V
TIPQTGG
I
G
T
I
L
F
T
I
I
G
L
S
I
M
L
G
A
V
V
V
M
K
KRQSEEA
1
PsiBlast_PDB
91.75
74%
-19
- C2 -
2XTL
2
?
A:
[3-451]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
K
P
Q
V
D
K
N
F
A
D
K
E
L
---
D
Y
A
N
N
K
K
D
K
G
T
V
S
A
S
V
G
D
V
K
K
Y
H
V
G
T
K
I
L
K
---
G
S
-----
D
-
Y
K
K
L
I
W
T
D
S
M
T
K
--
G
L
T
F
N
-
N
D
I
A
--
V
T
L
D
G
A
T
----
L
D
-----
A
T
N
Y
K
L
V
A
----
D
D
Q
G
F
R
--
L
V
L
T
D
K
G
L
E
A
V
A
K
A
A
------------------
K
--
T
K
D
V
E
------------------
I
K
I
T
Y
S
A
T
L
N
G
S
A
V
V
E
V
L
E
T
N
D
V
K
L
D
Y
G
N
N
P
T
I
E
N
E
P
K
E
G
I
P
-
V
-
D
K
-
K
I
T
V
N
K
T
W
A
V
D
G
N
E
---------
V
N
--
K
A
D
E
T
V
D
A
V
F
T
L
Q
V
K
D
G
D
-
K
W
V
N
V
D
S
A
K
A
T
A
A
T
S
F
-------------------
K
H
T
F
E
N
L
D
---------
N
A
K
T
Y
R
V
I
E
R
-
V
S
G
Y
A
P
E
Y
V
S
F
V
-
N
-
G
V
V
T
I
K
N
N
K
D
S
N
E
P
T
P
I
N
P
S
-
E
P
K
V
V
T
Y
G
R
K
F
V
K
T
N
K
D
---
G
-
K
E
R
L
A
G
A
T
F
-
L
V
---
K
K
D
---
G
K
---
Y
---
L
-
A
-
R
K
S
G
V
A
T
D
A
E
K
A
A
V
D
S
T
K
S
A
L
D
A
A
V
K
A
Y
N
D
L
T
K
E
K
Q
E
G
Q
D
G
K
S
A
L
A
T
V
S
E
K
Q
K
A
Y
N
D
A
F
V
K
A
N
Y
S
Y
E
W
V
E
D
K
-
N
-
A
-
K
N
V
V
K
L
I
S
N
D
K
G
Q
F
E
I
T
G
L
T
E
---------------
G
--------------------
Q
Y
S
L
E
E
T
Q
A
P
T
---------
G
Y
A
K
L
S
G
D
V
S
F
N
V
N
A
T
S
Y
S
K
G
S
A
Q
-
D
I
E
Y
T
Q
G
S
K
T
K
D
A
Q
Q
V
I
N
K
K
V
T
-----------------------------------
18
PsiBlast_CBE
91.08
74%
-20
- C2 -
2XTL
1
?
B:
[1-452]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
E
T
K
P
Q
V
D
K
N
F
A
D
K
E
L
---
D
Y
A
N
N
K
K
D
K
G
T
V
S
A
S
V
G
D
V
K
K
Y
H
V
G
T
K
I
L
K
---
G
S
-----
D
-
Y
K
K
L
I
W
T
D
S
M
T
K
--
G
L
T
F
N
-
N
D
I
A
--
V
T
L
D
G
A
T
----
L
D
-----
A
T
N
Y
K
L
V
A
----
D
D
Q
G
F
R
--
L
V
L
T
D
K
G
L
E
A
V
A
K
A
A
------------------
K
--
T
K
D
V
E
------------------
I
K
I
T
Y
S
A
T
L
N
G
S
A
V
V
E
V
L
E
T
N
D
V
K
L
D
Y
G
N
N
P
T
I
E
N
E
P
K
E
G
I
P
-
V
-
D
K
-
K
I
T
V
N
K
T
W
A
V
D
G
N
E
---------
V
N
--
K
A
D
E
T
V
D
A
V
F
T
L
Q
V
K
D
G
D
-
K
W
V
N
V
D
S
A
K
A
T
A
A
T
S
F
-------------------
K
H
T
F
E
N
L
D
---------
N
A
K
T
Y
R
V
I
E
R
-
V
S
G
Y
A
P
E
Y
V
S
F
V
-
N
-
G
V
V
T
I
K
N
N
K
D
S
N
E
P
T
P
I
N
P
S
-
E
P
K
V
V
T
Y
G
R
K
F
V
K
T
N
K
D
---
G
-
K
E
R
L
A
G
A
T
F
-
L
V
---
K
K
D
---
G
K
---
Y
---
L
-
A
-
R
K
S
G
V
A
T
D
A
E
K
A
A
V
D
S
T
K
S
A
L
D
A
A
V
K
A
Y
N
D
L
T
K
E
K
Q
E
G
Q
D
G
K
S
A
L
A
T
V
S
E
K
Q
K
A
Y
N
D
A
F
V
K
A
N
Y
S
Y
E
W
V
E
D
K
-
N
-
A
-
K
N
V
V
K
L
I
S
N
D
K
G
Q
F
E
I
T
G
L
T
E
---------------
G
--------------------
Q
Y
S
L
E
E
T
Q
A
P
T
---------
G
Y
A
K
L
S
G
D
V
S
F
N
V
N
A
T
S
Y
S
K
G
S
A
Q
-
D
I
E
Y
T
Q
G
S
K
T
K
D
A
Q
Q
V
I
N
K
K
V
T
I
----------------------------------
22
HHSearch
90.65
75%
-18
- C2 -
2XTL
2
?
A:
[5-451]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Q
V
D
K
N
F
A
D
K
E
L
---
D
Y
A
N
N
K
K
D
K
G
T
V
S
A
S
V
G
D
V
K
K
Y
H
V
G
T
K
I
L
K
---
G
S
-----
D
-
Y
K
K
L
I
W
T
D
S
M
T
K
--
G
L
T
F
N
-
N
D
I
A
--
V
T
L
D
G
A
T
----
L
D
-----
A
T
N
Y
K
L
V
A
----
D
D
Q
G
F
R
--
L
V
L
T
D
K
G
L
E
A
V
A
K
A
A
------------------
K
--
T
K
D
V
E
------------------
I
K
I
T
Y
S
A
T
L
N
G
S
A
V
V
E
V
L
E
T
N
D
V
K
L
D
Y
G
N
N
P
T
I
E
N
E
P
K
E
G
I
P
-
V
-
D
K
-
K
I
T
V
N
K
T
W
A
V
D
G
N
E
V
N
K
AD
E
T
V
D
A
V
F
T
L
Q
V
K
D
G
D
------------
K
W
V
N
V
D
S
A
K
A
T
A
A
T
S
F
-------------------
K
H
T
F
E
N
L
D
---------
N
A
K
T
Y
R
V
I
E
R
-
V
S
G
Y
A
P
E
Y
V
S
F
V
-
N
-
G
V
V
T
I
K
N
N
K
D
S
N
E
P
T
P
I
N
P
S
-
E
P
K
V
V
T
Y
G
R
K
F
V
K
T
N
K
D
---
G
-
K
E
R
L
A
G
A
T
F
-
L
V
---
K
K
D
---
G
K
---
Y
---
L
-
A
-
R
K
S
G
V
A
T
D
A
E
K
A
A
V
D
S
T
K
S
A
L
D
A
A
V
K
A
Y
N
D
L
T
K
E
K
Q
E
G
Q
D
G
K
S
A
L
A
T
V
S
E
K
Q
K
A
Y
N
D
A
F
V
K
A
N
Y
S
Y
E
W
V
E
D
K
-
N
-
A
-
K
N
V
V
K
L
I
S
N
D
K
G
Q
F
E
I
T
G
L
T
E
---------------
G
--------------------
Q
Y
S
L
E
E
T
Q
A
P
T
---------
G
Y
A
K
L
S
G
D
V
S
F
N
V
N
A
T
S
Y
S
K
G
S
A
Q
-
D
I
E
Y
T
Q
G
S
K
T
K
D
A
Q
Q
V
I
N
K
K
V
T
-----------------------------------
2
PsiBlast_PDB
89.27
42%
-5
- C2 -
2Y1V
3
?
A:
[5-604]
--------------------------------
T
T
T
S
V
T
V
H
K
L
L
A
T
D
G
D
M
D
K
I
A
N
E
L
E
T
G
N
---
Y
A
G
N
K
V
G
V
L
P
A
-----
N
A
K
E
I
A
G
V
M
F
V
W
T
N
-
T
N
N
E
I
I
D
E
N
G
Q
T
----
L
G
V
N
I
D
P
Q
---
T
F
K
L
S
G
-
A
----
M
-
P
--
A
T
A
M
K
K
L
T
E
A
E
G
A
-
K
F
N
T
A
N
L
-
P
A
A
K
Y
K
I
Y
E
I
H
S
L
S
T
Y
V
G
-
E
D
G
A
T
L
T
G
S
K
A
V
P
I
E
I
E
L
P
L
N
D
---------
V
V
D
A
H
V
Y
P
K
N
T
E
A
K
P
K
I
D
K
D
F
K
G
K
A
N
---
P
D
T
P
R
V
D
K
D
T
P
V
N
H
Q
V
G
D
V
V
E
Y
E
I
V
T
K
I
P
A
---
L
A
-----
N
-
Y
A
T
A
N
W
S
D
R
M
T
E
--
G
L
A
F
N
K
G
T
V
K
--
V
T
V
D
D
V
A
----
L
E
-----
A
G
D
Y
A
L
T
E
----
V
A
T
G
F
D
--
L
K
L
T
D
A
G
L
A
K
V
----------------------
N
--
D
Q
N
A
E
K
T
----------------
V
K
I
T
Y
S
A
T
L
N
D
K
A
I
V
E
V
P
E
S
N
D
V
T
F
N
Y
G
N
N
P
D
H
G
N
T
P
K
P
N
K
P
N
E
-
N
G
-
D
L
T
L
T
K
T
W
-
V
D
A
T
----------
G
A
--
P
I
P
A
G
A
E
A
T
F
D
L
V
N
A
Q
T
-
G
K
V
V
Q
T
V
T
L
T
T
D
K
N
T
V
----------------------
T
V
N
G
L
D
---------
K
N
T
E
Y
K
F
V
E
R
S
I
K
G
Y
S
A
D
Y
Q
E
I
T
-
T
A
G
E
I
A
V
K
N
W
K
D
E
N
-
P
K
P
L
D
P
T
-
E
P
K
V
V
T
Y
G
K
K
F
V
K
V
N
D
K
---
D
-
N
-
R
L
A
G
A
E
F
-
V
I
---
A
N
A
D
N
A
G
Q
---
Y
---
L
-
A
-
R
K
A
D
K
V
S
Q
E
E
K
Q
L
V
V
T
T
K
D
A
L
D
R
A
V
A
A
Y
N
A
L
T
A
Q
Q
Q
T
----
Q
Q
E
K
E
K
V
D
K
A
Q
A
A
Y
N
A
A
V
I
A
A
N
N
A
F
E
W
V
A
D
K
-
D
-
N
-
E
N
V
V
K
L
V
S
D
A
Q
G
R
F
E
I
T
G
L
L
A
---------------
G
--------------------
T
Y
Y
L
E
E
T
K
Q
P
A
---------
G
Y
A
L
L
T
S
R
Q
K
F
E
V
T
A
T
S
Y
S
-
A
T
G
Q
-
G
I
E
Y
T
A
G
S
G
K
D
D
A
T
K
V
V
N
K
K
I
T
I
P
Q
T
G
------------------------------
19
HHSearch
87.11
43%
-9
- C2 -
2Y1V
3
?
A:
[4-604]
-------------------------------
T
T
T
T
S
V
T
V
H
K
L
L
A
T
D
G
D
M
D
K
I
A
N
E
L
---
E
T
G
N
Y
A
G
N
K
V
----
G
V
L
P
-
A
N
A
K
E
I
A
G
V
M
F
V
W
T
N
T
N
N
E
I
I
D
E
-
N
G
Q
T
LG
V
N
I
------
D
---
P
Q
T
F
K
L
-
S
----
G
-
A
MP
A
T
A
M
K
K
L
T
E
A
E
G
A
-
K
F
N
T
A
N
L
P
A
A
K
-
Y
K
I
Y
E
I
H
S
L
S
T
Y
-
V
G
E
D
G
A
T
L
T
G
S
K
A
V
P
I
E
I
E
L
P
L
N
D
---------
V
V
D
A
H
V
Y
P
K
N
T
E
A
K
P
K
I
D
K
D
F
K
G
K
A
N
PDT
P
R
V
D
K
D
T
---
P
V
N
H
Q
V
G
D
V
V
E
Y
E
I
V
T
K
I
P
A
---
L
A
-----
N
-
Y
A
T
A
N
W
S
D
R
M
T
E
--
G
L
A
F
N
-
K
G
T
V
K
-
V
T
V
D
D
V
A
----
L
E
-----
A
G
D
Y
A
L
T
E
----
V
A
T
G
F
D
--
L
K
L
T
D
A
G
L
A
K
V
N
D
Q
----------------------
N
A
E
K
T
------------------
V
K
I
T
Y
S
A
T
L
N
D
K
A
I
V
E
V
P
E
S
N
D
V
T
F
N
Y
G
N
N
P
D
H
G
N
T
P
K
P
N
K
P
-
N
E
N
G
-
D
L
T
L
T
K
T
W
V
D
A
T
G
APIPAG
A
E
--
A
T
F
D
L
V
N
A
Q
-
T
G
K
V
V
Q
T
--------------
V
T
L
T
T
D
K
N
-------------------
T
V
T
V
N
G
L
D
---------
K
N
T
E
Y
K
F
V
E
R
S
I
K
G
Y
S
A
D
Y
Q
E
I
T
T
A
-
G
E
I
A
V
K
N
W
K
D
-
E
N
P
K
P
L
D
P
T
-
E
P
K
V
V
T
Y
G
K
K
F
V
K
V
N
D
K
-----
D
N
R
L
A
G
A
E
F
-
V
I
---
A
N
A
---
D
N
A
G
Q
Y
---
L
-
A
-
R
K
A
D
K
V
S
Q
E
E
K
Q
L
V
V
T
T
K
D
A
L
D
R
A
V
A
A
Y
N
A
L
----
T
A
Q
Q
Q
T
Q
Q
E
K
E
K
V
D
K
A
Q
A
A
Y
N
A
A
V
I
A
A
N
N
A
F
E
W
V
A
D
K
-
D
-
N
-
E
N
V
V
K
L
V
S
D
A
Q
G
R
F
E
I
T
G
L
L
A
---------------
G
--------------------
T
Y
Y
L
E
E
T
K
Q
P
A
---------
G
Y
A
L
L
T
S
R
Q
K
F
E
V
T
A
T
S
Y
S
A
T
G
Q
G
I
E
Y
T
A
--
G
S
G
K
D
D
A
T
K
V
V
N
K
K
I
T
I
P
Q
T
G
------------------------------
4
PsiBlast_PDB
77.44
44%
2
- C2 -
2X9Y
-
?
A:
[187-625]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
P
K
I
D
K
D
F
K
G
K
A
N
---
P
D
T
P
R
V
D
K
D
T
P
V
N
H
Q
V
G
D
V
V
E
Y
E
I
V
T
K
I
P
A
---
L
A
-----
N
-
Y
A
T
A
N
W
S
D
R
M
T
E
--
G
L
A
F
N
K
G
T
V
K
--
V
T
V
D
D
V
A
----
L
E
-----
A
G
D
Y
A
L
T
E
----
V
A
T
G
F
D
--
L
K
L
T
D
A
G
L
A
K
V
----------------------
N
--
D
Q
N
A
E
K
T
----------------
V
K
I
T
Y
S
A
T
L
N
D
K
A
I
V
E
V
P
E
S
N
D
V
T
F
N
Y
G
N
N
P
D
H
G
N
T
P
K
P
N
K
P
N
E
-
N
G
-
D
L
T
L
T
K
T
W
-
V
D
A
T
----------
G
A
--
P
I
P
A
G
A
E
A
T
F
D
L
V
N
A
Q
A
-
G
K
V
V
Q
T
V
T
L
T
T
D
K
N
T
V
----------------------
T
V
N
G
L
D
---------
K
N
T
E
Y
K
F
V
E
R
S
I
K
G
Y
S
A
D
Y
Q
E
I
T
-
T
A
G
E
I
A
V
K
N
W
K
D
E
N
-
P
K
P
L
D
P
T
-
E
P
K
V
V
T
Y
G
K
K
F
V
K
V
N
D
K
---
D
-
N
-
R
L
A
G
A
E
F
-
V
I
A
NA
D
N
A
---
G
Q
---
Y
---
L
-
A
-
R
K
A
D
K
V
S
Q
E
E
K
Q
L
V
V
T
T
K
D
A
L
D
R
A
V
A
A
Y
N
A
L
T
A
Q
Q
Q
T
----
Q
Q
E
K
E
K
V
D
K
A
Q
A
A
Y
N
A
A
V
I
A
A
N
N
A
F
E
W
V
A
D
K
-
D
-
N
-
E
N
V
V
K
L
V
S
D
A
Q
G
R
F
E
I
T
G
L
L
A
---------------
G
--------------------
T
Y
Y
L
E
E
T
K
Q
P
A
---------
G
Y
A
L
L
T
S
R
Q
K
F
E
V
T
A
T
S
Y
S
-
A
T
G
Q
-
G
I
E
Y
T
A
G
S
G
K
D
D
A
T
K
V
V
N
K
K
-------------------------------------
6
PsiBlast_PDB
76.57
44%
-2
- C2 -
2X9X
2
?
A:
[4-440]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
P
K
I
D
K
D
F
K
G
K
A
N
---
P
D
T
P
R
V
D
K
D
T
P
V
N
H
Q
V
G
D
V
V
E
Y
E
I
V
T
K
I
P
A
---
L
A
-----
N
-
Y
A
T
A
N
W
S
D
R
M
T
E
--
G
L
A
F
N
K
G
T
V
K
--
V
T
V
D
D
V
A
----
L
E
-----
A
G
D
Y
A
L
T
E
----
V
A
T
G
F
D
--
L
K
L
T
D
A
G
L
A
K
V
----------------------
N
--
D
Q
N
A
E
K
T
----------------
V
K
I
T
Y
S
A
T
L
N
D
K
A
I
V
E
V
P
E
S
N
D
V
T
F
N
Y
G
N
N
P
D
H
G
N
T
P
K
P
N
K
P
N
E
-
N
G
-
D
L
T
L
T
K
T
W
-
V
D
A
T
----------
G
A
--
P
I
P
A
G
A
E
A
T
F
D
L
V
N
A
Q
A
-
G
K
V
V
Q
T
V
T
L
T
T
D
K
N
T
V
----------------------
T
V
N
G
L
D
---------
K
N
T
E
Y
K
F
V
E
R
S
I
K
G
Y
S
A
D
Y
Q
E
I
T
-
T
A
G
E
I
A
V
K
N
W
K
D
E
N
-
P
K
P
L
D
P
T
-
E
P
K
V
V
T
Y
G
K
K
F
V
K
V
N
D
K
---
D
-
N
-
R
L
A
G
A
E
F
-
V
I
A
NA
D
N
A
---
G
Q
---
Y
---
L
-
A
-
R
K
A
D
K
V
S
Q
E
E
K
Q
L
V
V
T
T
K
D
A
L
D
R
A
V
A
A
Y
N
A
L
T
A
Q
----------
K
E
K
V
D
K
A
Q
A
A
Y
N
A
A
V
I
A
A
N
N
A
F
E
W
V
A
D
K
-
D
-
N
-
E
N
V
V
K
L
V
S
D
A
Q
G
R
F
E
I
T
G
L
L
A
---------------
G
--------------------
T
Y
Y
L
E
E
T
K
Q
P
A
---------
G
Y
A
L
L
T
S
R
Q
K
F
E
V
T
A
T
S
Y
S
-
A
T
G
Q
-
G
I
E
Y
T
A
G
S
G
K
D
D
A
T
K
V
V
N
---------------------------------------
5
PsiBlast_PDB
76.55
44%
1
- C2 -
2X9W
3
?
A:
[3-444]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
K
P
K
I
D
K
D
F
K
G
K
A
N
---
P
D
T
P
R
V
D
K
D
T
P
V
N
H
Q
V
G
D
V
V
E
Y
E
I
V
T
K
I
P
A
---
L
A
-----
N
-
Y
A
T
A
N
W
S
D
R
M
T
E
--
G
L
A
F
N
K
G
T
V
K
--
V
T
V
D
D
V
A
----
L
E
-----
A
G
D
Y
A
L
T
E
----
V
A
T
G
F
D
--
L
K
L
T
D
A
G
L
A
K
V
----------------------
N
--
D
Q
N
A
E
K
T
----------------
V
K
I
T
Y
S
A
T
L
N
D
K
A
I
V
E
V
P
E
S
N
D
V
T
F
N
Y
G
N
N
P
D
H
G
N
T
P
K
P
N
K
P
N
E
-
N
G
-
D
L
T
L
T
K
T
W
-
V
D
A
T
----------
G
A
--
P
I
P
A
G
A
E
A
T
F
D
L
V
N
A
Q
A
-
G
K
V
V
Q
T
V
T
L
T
T
D
K
N
T
V
----------------------
T
V
N
G
L
D
---------
K
N
T
E
Y
K
F
V
E
R
S
I
K
G
Y
S
A
D
Y
Q
E
I
T
-
T
A
G
E
I
A
V
K
N
W
K
D
E
N
-
P
K
P
L
D
P
T
-
E
P
K
V
V
T
Y
G
K
K
F
V
K
V
N
D
K
---
D
-
N
-
R
L
A
G
A
E
F
-
V
I
A
NA
D
N
A
---
G
Q
---
Y
---
L
-
A
-
R
K
A
D
K
V
S
Q
E
E
K
Q
L
V
V
T
T
K
D
A
L
D
R
A
V
A
A
Y
N
A
L
T
A
Q
Q
Q
T
----
Q
Q
E
K
E
K
V
D
K
A
Q
A
A
Y
N
A
A
V
I
A
A
N
N
A
F
E
W
V
A
D
K
-
D
-
N
-
E
N
V
V
K
L
V
S
D
A
Q
G
R
F
E
I
T
G
L
L
A
---------------
G
--------------------
T
Y
Y
L
E
E
T
K
Q
P
A
---------
G
Y
A
L
L
T
S
R
Q
K
F
E
V
T
A
T
S
Y
S
-
A
T
G
Q
-
G
I
E
Y
T
A
G
S
G
K
D
D
A
T
K
V
V
N
K
K
I
T
-----------------------------------
23
HHSearch
73.74
45%
-8
- C2 -
2X9X
2
?
A:
[28-440]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
N
H
Q
V
G
D
V
V
E
Y
E
I
V
T
K
I
P
A
---
L
A
-----
N
-
Y
A
T
A
N
W
S
D
R
M
T
E
--
G
L
A
F
N
-
K
G
T
V
K
-
V
T
V
D
D
V
A
----
L
E
-----
A
G
D
Y
A
L
T
E
----
V
A
T
G
F
D
--
L
K
L
T
D
A
G
L
A
K
V
N
D
--------------------
Q
--
N
A
E
K
T
------------------
V
K
I
T
Y
S
A
T
L
N
D
K
A
I
V
E
V
P
E
S
N
D
V
T
F
N
Y
G
N
N
P
D
H
G
N
T
P
K
P
N
K
P
-
N
E
N
G
-
D
L
T
L
T
K
T
W
V
D
A
T
G
APIPAG
A
E
--
A
T
F
D
L
V
N
A
Q
-
A
G
K
V
V
Q
--------------
T
V
T
L
T
T
D
K
N
-------------------
T
V
T
V
N
G
L
D
---------
K
N
T
E
Y
K
F
V
E
R
S
I
K
G
Y
S
A
D
Y
Q
E
I
T
T
A
-
G
E
I
A
V
K
N
W
K
D
-
E
N
P
K
P
L
D
P
T
-
E
P
K
V
V
T
Y
G
K
K
F
V
K
V
N
D
K
-----
D
N
R
L
A
G
A
E
F
-
V
I
---
A
N
A
---
D
N
---
A
G
Q
Y
L
-
A
-
R
K
A
D
K
V
S
Q
E
E
K
Q
L
V
V
T
T
K
D
A
L
D
R
A
V
A
A
Y
N
A
L
T
----
A
Q
------
K
E
K
V
D
K
A
Q
A
A
Y
N
A
A
V
I
A
A
N
N
A
F
E
W
V
A
D
K
-
D
-
N
-
E
N
V
V
K
L
V
S
D
A
Q
G
R
F
E
I
T
G
L
L
A
---------------
G
--------------------
T
Y
Y
L
E
E
T
K
Q
P
A
---------
G
Y
A
L
L
T
S
R
Q
K
F
E
V
T
A
T
S
Y
S
A
T
G
Q
G
--
I
E
Y
T
A
G
S
G
K
D
D
A
T
K
V
V
N
---------------------------------------
3
PsiBlast_PDB
61.44
42%
71
- C2 -
3RPK
-
?
A:
[33-627]
--------------------------------
T
T
T
S
V
T
V
H
K
L
L
A
T
D
G
D
M
D
K
I
A
N
E
L
--------
A
G
N
K
V
G
V
L
P
A
-----
N
A
K
E
I
A
G
V
M
F
V
W
T
N
-
T
N
N
E
I
I
D
E
N
G
Q
T
----
L
G
V
N
I
D
P
Q
---
T
F
K
L
S
G
-
A
----
M
-
P
--
A
T
A
M
K
K
L
T
E
A
E
G
A
-
K
F
N
T
A
N
L
-
P
A
A
K
Y
K
I
Y
E
I
H
S
L
S
T
Y
V
G
-
E
D
G
A
T
L
T
G
S
K
A
V
P
I
E
I
E
L
P
L
N
D
---------
V
V
D
A
H
V
Y
P
K
N
T
E
A
K
P
K
I
D
K
D
F
K
G
K
A
N
---
P
D
T
P
R
V
D
K
D
T
P
V
N
H
Q
V
G
D
V
V
E
Y
E
I
V
T
K
I
P
A
---
L
A
-----
N
-
Y
A
T
A
N
W
S
D
R
M
T
E
--
G
L
A
F
N
K
G
T
V
K
--
V
T
V
D
D
V
A
----
L
E
-----
A
G
D
Y
A
L
T
E
----
V
A
T
G
F
D
--
L
K
L
T
D
A
G
L
A
K
V
----------------------
N
--
D
Q
N
A
E
K
T
----------------
V
K
I
T
Y
S
A
T
L
N
D
K
A
I
V
E
V
P
E
S
N
D
V
T
F
N
Y
G
N
N
P
D
H
G
N
T
P
K
P
N
K
P
N
E
-
N
G
-
D
L
T
L
T
K
T
W
-
V
D
A
T
----------
G
A
--
P
I
P
A
G
A
E
A
T
F
D
L
V
N
A
Q
T
-
G
K
V
V
Q
T
V
T
L
T
T
D
K
N
T
V
----------------------
T
V
N
G
L
D
---------
K
N
T
E
Y
K
F
V
E
R
S
I
K
G
Y
S
A
D
Y
Q
E
I
T
-
T
A
G
E
I
A
V
K
N
W
K
D
E
N
-
P
K
P
L
D
P
T
-
E
P
K
V
V
T
Y
G
K
K
F
V
K
V
N
D
K
---
D
-
N
-
R
L
A
G
A
E
F
-
V
I
---
A
N
A
DNA
G
Q
---
Y
---
L
-
A
-
R
K
A
D
K
V
S
Q
E
E
K
Q
L
V
V
T
T
K
D
A
L
D
R
A
V
A
A
Y
N
A
L
T
A
Q
Q
Q
T
----
Q
Q
E
K
E
K
V
D
K
A
Q
A
A
Y
N
A
A
V
I
A
A
N
N
A
F
E
W
V
A
D
K
-
D
-
N
-
E
N
V
V
K
L
V
S
D
A
Q
G
R
F
E
I
T
G
L
L
A
---------------
G
--------------------
T
Y
Y
L
E
E
T
K
Q
P
A
---------
G
Y
A
L
L
T
S
R
Q
K
F
E
V
T
A
T
S
Y
S
-
A
T
G
Q
-
G
I
E
Y
T
A
G
S
G
K
D
D
A
T
K
V
V
N
K
K
I
T
-----------------------------------
24
HHSearch
56.72
27%
-3
- C2 -
3PF2
2
?
A:
[3-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
D
E
--
P
K
T
D
K
D
V
K
K
---------
L
G
Q
D
---
D
A
G
Y
T
I
G
E
E
F
K
W
F
L
K
S
T
I
P
A
---
N
L
G----
D
-
Y
E
K
F
E
I
T
D
K
F
A
D
--
G
L
T
Y
K
-
S
V
G
K
--
I
K
I
G
S
K
T
L
---
N
R
-----
D
E
H
Y
T
I
D
E
P
T
VD
N
Q
N
T
L
K
--
I
T
F
K
P
E
K
F
K
E
I
A
E
L
L
KG
M
T
L
V
K
N
Q
D
A
L
D
K
ATAN
T
--
D
D
A
A
F
------------------
L
E
I
P
V
A
S
T
I
N
E
K
A
V
L
G
K
A
I
E
N
T
F
E
L
Q
Y
D
H
T
P
D
K
A
D
N
P
K
---------------------------------------------------------------------------------------------------------------------------------------------------
P
-
S
N
P
P
R
-
K
P
E
V
H
T
G
G
K
R
F
V
K
K
D
S
T
---
E
-
T
Q
T
L
G
G
A
E
F
-
D
L
---
L
A
S
---
D
G
---
T
---
A
V
K
-
W
T
D
-----------
A
L
I
-------------------------------------------
K
A
N
T
N
K
N
Y
I
A
G
E
A
V
-
T
-
G
Q
P
I
K
L
K
S
H
T
D
G
T
F
E
I
K
G
L
A
Y
---------------
A
VDANAE
G
T
A
V
----------
T
Y
K
L
K
E
T
K
A
P
E
---------
G
Y
V
I
P
D
K
E
I
E
F
T
V
S
Q
T
S
Y
N
T
K
P
T
D
-
I
T
V
D
S
A
D
A
T
P
D
T
I
K
N
N
K
R
---------------------------------------
26
HHSearch
54.18
20%
-12
- C2 -
3KPT
-
?
A:
[19-343]
--------------------------------------------------------------------------------
E
K
A
M
A
G
A
V
F
S
L
F
K
K
D
G
T
E
V
K
-----------------------------------------
K
E
L
A
T
D
A
N
G
H
I
R
V
--
Q
G
L
E
Y
G
E
-
Y
Y
F
Q
E
T
K
A
P
K
G
Y
-
V
-------
I
D
P
T
K
R
E
F
F
V
K
N
S
G
T
I
N
E-
D
G
T
I
TS
G
T
V
V
K
M
E
V
K
N
N
E
E
-
P
T
I
D
K
K
I
N
G
K
L
E
-------------
A
L
P
I
N
P
L
T
N
Y
N
Y
D
I
K
T
L
I
P
E
---
D
I
K----
E
-
Y
K
K
Y
V
V
T
D
T
L
D
N
--
R
L
V
I
Q
-
G
K
P
I
--
V
K
I
D
G
A
E
----
V
N
-----
A
N
V
V
E
V
A
I
----
E
G
Q
K
V
T
--
A
T
V
K
D
--
F
T
K
M
D
G
-------------------------
K
K
E
------------------
F
H
L
Q
I
K
S
Q
V
K
E
G
V
P
S
G
S
E
I
L
N
T
A
K
I
H
F
T
N
K
N
D
V
I
G
E
------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
S
K
P
V
-
V
V
I
P
T
T
G
I
I
E
L
T
K
I
D
S
A
---
N
-
K
N
K
M
K
G
A
E
F
-
V
L
---
K
D
N
---
N
G
---
K
---
I
-
V
-
V
V
-----------------------------------------------------------
A
---------------
G
K
E
V
T
G
V
S
D
E
N
G
V
I
K
W
S
N
I
P
Y
---------------
G
--------------------
D
Y
Q
I
F
E
T
K
A
P
T
Y
T
K
EDGTKT
S
Y
Q
L
L
K
D
P
I
D
V
K
I
S
E
N
N
Q
T
V
K
L
T
I
-
E
N
N
K
S
----------------------------------------------------
21
HHSearch
51.71
18%
6
- C2 -
3HR6
2
?
A:
[4-419]
---------------------------------
R
T
S
I
A
V
H
A
L
M
G
L
P
T
G
-------------------------------
G
L
P
K
V
D
G
M
S
F
T
L
Y
R
V
N
E
I
D
L
T
T
Q
A
G
W
D
A
---
A
------
S
K
IK
L
E
E
L
Y
T
-
N
GHPT
D
-
K
--
V
T
K
V
A
T
K
K
T
E
G
G
V
A
K
F
--
D
N
L
T
P
A
L
-
Y
L
V
V
Q
E
L
N
G
A
---------
E
-
A
V
V
R
S
Q
P
F
L
V
A
A
P
Q
T
N
PT-
G
D
G
W
--
L
Q
D
V
H
V
Y
P
K
H
Q
A
L
-
S
E
P
V
K
T
A
V
D
P
---------
D
A
T
---
Q
P
G
F
S
V
G
E
N
V
K
Y
R
V
A
T
K
I
P
E
---
I
A
SNT--
K
-
F
E
G
F
T
V
A
D
K
L
P
A
--
E
L
G
K
P
-
D
T
N
K
I
T
V
T
L
G
G
K
P
----
I
N
-----
S
T
D
V
S
V
Q
T
Y
Q
VG
D
R
T
V
L
S
--
V
Q
L
A
G
A
T
L
Q
S
L
D
Q
-----------------------
H
K
D
Q
E
------------------
L
V
V
E
F
E
A
P
V
T
K
Q
P
E
N
G
-
Q
L
D
N
Q
A
W
V
L
P
S
N
P
T
A
Q
W
D
P
E
E
S
G
-
D
---------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
R
G
M
P
S
S
-
R
V
S
S
K
F
G
Q
I
T
I
E
K
S
F
D
G
---
N
T
P
G
A
D
R
T
A
T
F
-
Q
L
---
H
R
C
---
E
A
---
D
---
G
-
S
-
L
V
---------------
K
-------------------------------------------
S
D
P
P
I
S
L
D
G
---------
K
Q
E
F
V
T
G
Q
D
G
K
A
V
L
S
G
I
H
L
---------------
G
T
L
Q
L
E
SN
V
M
K
Y
T
D
AWAGKGT
E
F
C
L
V
E
T
A
T
A
S
---------
G
Y
E
L
L
P
K
P
V
I
V
K
L
E
A
N
E
S
T
N
V
L
V
E
-
Q
K
V
K
I
D
N
K
K
------------------------------------------------
20
HHSearch
51.06
22%
7
- C2 -
3UXF
4
FM1_ACTVI
A:
[37-473]
----------------------------
I
D
P
D
A
A
T
T
L
T
V
H
K
C
E
Q
T
------------------
G
T
G
N
E
D
----
P
---
Q
A
E
C
K
P
V
S
D
V
E
F
T
I
T
K
L
N
-
V
D
L
T
T
Y
D
G
W
K
T
---
L
------
A
D
L
K
G
D
V
V
K
A
G
A
----
L
K
S
--
T
T
V
Q
K
I
T
T
G
A
N
G
L
A
S
F
T
D
A
Q
T
E
V
G
A
-
Y
L
V
S
E
T
R
T
P
D
-----------
K
V
I
P
A
E
D
F
V
V
T
L
P
M
T
N
PQD
T
A
K
W
--
N
Y
N
V
H
V
Y
P
K
N
T
L
--
S
G
V
D
K
Q
V
T
D
----------------
K
P
A
P
G
S
G
R
D
I
T
Y
T
I
T
T
S
I
P
K
---
V
D
YPGGA
R
-
I
K
R
Y
E
V
V
D
R
L
D
K
--
R
I
K
K
E
-
A
L
T
P
V
-
V
K
I
V
G
Q
N
E
V
T
L
A
E
-----
T
T
D
Y
T
L
I
T
A
E
G
K
D
H
N
W
A
T
--
I
Q
L
T
E
E
G
R
R
K
A
S
E
A
R
------------------
Y
N
G
N
G
E
T
K
------------------
L
Q
V
T
L
N
A
K
F
D
A
A
V
N
L
E
G
D
L
S
N
T
A
G
L
I
P
N
D
S
P
N
F
T
W
D
P
N
N
--
P
----------------------------------------------------------------
G
--------------------------------------------------------------------
T
T
------
T
D
I
P
G
I
P
T
T
-
P
V
L
S
K
Y
G
K
V
I
L
T
K
T
G
T
D
DLA
D
-
K
T
K
Y
N
G
A
Q
F
-
Q
V
---
Y
E
C
---
T
K
---
T
---
A
-
S
G
A
T
-------------
L
R
--------------------------------------------
D
S
D
P
S
T
Q
T
V
D
P
-
L
T
I
-
G
G
E
K
T
F
T
T
A
G
Q
G
T
V
E
I
N
Y
L
R
A
NDYVNGAKKDQLTDE
D
--------------------
Y
Y
C
L
V
E
T
K
A
P
E
---------
G
Y
N
L
Q
A
D
P
L
P
F
R
V
L
A
E
K
A
E
K
K
A
A
T
-
E
V
T
V
T
D
I
P
K
------------------------------------------------
8
PsiBlast_PDB
50.59
36%
-16
- C2 -
2L4O
-
?
A:
[23-191]
----------------------
S
A
A
T
V
F
A
A
G
T
T
T
T
S
V
T
V
H
K
L
L
A
T
D
G
D
M
D
K
I
A
N
E
L
E
T
G
N
---
Y
A
G
N
K
V
G
V
L
P
A
-----
N
A
K
E
I
A
G
V
M
F
V
W
T
N
-
T
N
N
E
I
I
D
E
N
G
Q
T
----
L
G
V
N
I
D
P
Q
---
T
F
K
L
S
G
-
A
----
M
-
P
--
A
T
A
M
K
K
L
T
E
A
E
G
A
-
K
F
N
T
A
N
L
-
P
A
A
K
Y
K
I
Y
E
I
H
S
L
S
T
Y
V
G
-
E
D
G
A
T
L
T
G
S
K
A
V
P
I
E
I
E
L
P
L
N
D
---------
V
V
D
A
H
V
Y
P
K
N
T
E
A
K
P
K
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
49.04
36%
-16
- C2 -
2L4O
-
?
A:
[31-186]
------------------------------
G
T
T
T
T
S
V
T
V
H
K
L
L
A
T
D
G
D
M
D
K
I
A
N
E
---
L
E
T
G
N
Y
A
G
N
K
V
----
G
V
L
P
-
A
N
A
K
E
I
A
G
V
M
F
V
W
T
N
T
N
N
E
I
I
D
E
N
G
Q
T
L
G---
V
------
N
I
D
-
P
Q
T
F
K
L
-
S
----
G
-
A
MP
A
T
A
M
K
K
L
T
E
A
E
G
A
-
K
F
N
T
A
N
L
P
A
A
K
-
Y
K
I
Y
E
I
H
S
L
S
T
Y
-
V
G
E
D
G
A
T
L
T
G
S
K
A
V
P
I
E
I
E
L
P
L
N
-------
D
--
V
V
D
A
H
V
Y
P
K
N
T
E
A
K
P
K
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
48.72
27%
5
- C2 -
3PF2
1
?
A:
[165-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
N
P
K
P
S
N
P
P
R
K
P
E
V
H
T
G
G
K
R
F
V
K
K
D
S
T
---
E
-
T
Q
T
L
G
G
A
E
F
D
L
L
---
A
S
D
---
G
-----------------------
T
A
V
K
---------------------------------------
W
T
D
A
L
I
K
A
N
T
N
K
N
Y
I
A
G
E
-
A
-
V
T
G
Q
P
I
K
L
K
S
H
T
D
G
T
F
E
I
K
G
L
A
Y
---------------
A
VDANAE
G
T
A
V
----------
T
Y
K
L
K
E
T
K
A
P
E
---------
G
Y
V
I
P
D
K
E
I
E
F
T
V
S
Q
T
S
Y
N
T
K
P
-
T
-
D
I
T
V
D
S
A
D
A
T
P
D
T
I
K
N
N
K
R
--------------------------------------
10
PsiBlast_PDB
47.38
27%
6
- C2 -
3PG2
1
?
A:
[165-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
N
P
K
P
S
N
P
P
R
K
P
E
V
H
T
G
G
K
R
F
V
K
K
D
S
T
---
E
-
T
Q
T
L
G
G
A
E
F
D
L
L
---
A
S
D
---
G
-----------------------
T
A
V
K
---------------------------------------
W
T
D
A
L
I
K
A
N
T
N
K
N
Y
I
A
G
E
-
A
-
V
T
G
Q
P
I
K
L
K
S
H
T
D
G
T
F
E
I
K
G
L
A
Y
---------------
A
VDANAE
G
T
A
V
----------
T
Y
K
L
K
E
T
K
A
P
E
---------
G
Y
V
I
P
D
K
E
I
E
F
T
V
S
Q
T
S
Y
N
T
K
P
-
T
-
D
I
T
V
D
S
A
D
A
T
P
D
T
I
K
N
N
K
R
--------------------------------------
42
Fugue
47.37
17%
5
- C2 -
3PF2
2
?
A:
[3-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
D
E
P
K
T
D
K
D
V
K
K
L
G
Q
---
D
---------
D
A
G
Y
T
I
G
E
E
F
K
W
F
L
K
S
T
I
P
A
---
N
L
-----
G
D
Y
E
K
F
E
I
T
D
K
F
A
D
--
G
L
T
Y
K
-
S
V
G
K
--
I
K
I
G
S
K
T
----
L
N
R
DEH
Y
T
I
D
E
P
T
V
D
----
N
Q
N
T
L
K
--
I
T
F
K
P
E
K
F
K
E
I
A
E
L
L
------------------
K
--
G
M
T
L
V
K
N
Q
D
A
L
D
K
ATANTDDAA
F
L
E
I
P
V
A
S
T
I
N
E
K
A
V
L
G
K
A
I
E
N
T
F
E
L
Q
Y
D
H
T
P
D
K
A
D
N
P
K
P
S
N
P
-
P
-
R
K
P
E
V
H
T
G
G
K
R
F
V
K
K
D
----------
S
T
--
E
T
Q
T
L
G
G
A
E
F
D
L
L
A
S
D
G
T
A
V
K
W
T
D
A
L
I
K
A
N
T
N
K
N
Y
IA
G
E
A
V
T
G
Q
P
I
K
L
K
S
H
TDG
T
F
E
I
K
G
L
A
YAVDANAE
G
T
A
V
T
Y
K
L
K
E
T
-
K
A
---
P
E
G
Y
V
I
P
-
D
-
K
E
I
E
F
T
V
S
Q
T
S
Y
N
T
K
P
T
D
I
T
-
V
D
S
A
D
A
T
P
D
T
I
K
N
N
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
47.01
23%
8
- C2 -
3HR6
1
?
A:
[113-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
Q
P
F
L
V
A
A
P
Q
T
N
PT-
G
D
G
W
--
L
Q
D
V
H
V
Y
P
K
H
Q
A
L
S
E
P
V
-
K
T
A
V
D
P
D
A
---
T
Q
P
---------
G
F
S
V
G
E
N
V
K
Y
R
V
A
T
K
I
P
E
IAS
N
T
-----
K
-
F
E
G
F
T
V
A
D
K
L
P
A
EL
G
K
P
D
T
-
N
K
I
T
--
V
T
L
G
G
K
P
----
I
N
-----
S
T
D
V
S
V
Q
T
----
Y
Q
V
G
D
R
T
V
L
S
V
Q
L
A
G
-
A
T
L
Q
S
L
D
------------------
Q
--
H
K
D
Q
E
------------------
L
V
V
E
F
E
A
P
V
--
T
K
Q
P
E
N
G
Q
L
D
N
Q
A
W
V
L
P
S
N
P
T
A
Q
W
D
P
E
E
S
G
D
-
A
-
A
L
-
R
G
M
P
S
S
R
V
S
S
K
F
G
----------
Q
I
--
T
I
E
K
S
F
D
G
N
T
P
G
A
D
R
T
A
T
F
Q
L
H
R
C
E
A
D
G
S
L
V
K
S
D
P
-------------------
P
I
S
L
D
G
K
Q
---------
E
F
V
T
G
Q
D
G
K
A
-
V
L
S
G
I
H
L
G
T
L
Q
L
-
E
-
S
N
V
M
K
Y
T
D
A
W
A
G
K
G
T
E
F
C
L
V
-
E
T
A
T
A
S
G
Y
E
L
L
P
K
P
V
I
V
---
K
-
L
E
A
N
E
S
T
N
V
-
L
V
---
E
Q
K
---
V
K
---
I
---
D
-
N
-
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------