@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1529: (2015-12-08 )
MSQKTFGKQLTVVDTKSRVKMHKSGKNWVRTVMSHFNLFKAIKGRATVEADVCIQDVEKEDRLSSGNLTYLKGILAAGALVGGASLTSRVYADETPVVQEQSSSVPTLAEQTEVTVKTTTVQNHQDGTVSKNIIDSNSVSMSESASTSTSESVSMSMSGSTLTSVSESVSTSALTSASESISTSASESVSKSTSISEVSNILETQASLTDKGRESFSANQIVTESSLVTDAGKNASVSSLIEITKPKSELQTSKMSNESLITPEKSQVMIASDKTGNESLTPTIRLKSVIQPRSMNLMTLSSEMDLIPLEEVSDTEMLGKDVSSELQKVNIALKDNTLSEPGTVKLDSSENLVLNFAFSIASVNEGDVFTVKLSDNLDTQGIGTILKVQDIMDETGQLLATGSYSPLTHNITYTWTRYASTLNNIKARVNMPVWPDQRIISKTTSDKQCFTATLNNQVASIEERVQYNSPSVTEHTNVKTNVRSRIMKLDDERQTETYITQINPEGKEMYFASGLGNLYTIIGSDGTSGSPVNLLNAEVKILKTNSKNLTDSMDQNYDSPEFEDVTSQYSYTNDGSKITIDWKTNSISSTTSYVVLVKIPKQSGVLYSTVSDINQTYGSKYSYGHTNISGDSDANAEIKLLSESASTSASTSASTSASMSASTSASTSASMSASTSASTSASMSASTSASTSASTSTSTSASTSASTSASTSASMSASTSASTSASTSASTSASTSASTSASTSASTSASTSASTSASTSASTSASTSASTSASTSASMSASMSASTSASMSASTSASTSASTSASTSASTSASTSASMSASTSASTSASTSASMSASTSASTSASTSASTSASTSTSTSASTSASTSASTSASMSASTSASTSPSTSASTSASTSASTSASTSASTSASMSASTSASTSASMSASTSASTSASTSASTSASMSASTSASTSASTSASMSASTSASTSASTSASTSASTSTSTSASTSASTSASTSASMSASTSASTSASTSASMSASTSASISASTSASMSASTSASTSASTSASTSASMSASTSASTSASTSASTSASMSASTSASTSASTSASTSASTSASTSASTSASTSSSTSASTSASTSASTSASMSASTSASTSASMSASTSASTSASTSASMSASTSSSTSASMSASTSASMSASTSASTSASTSASMSASTSSSTSASMSASTSASMSASTSASTSASTSASMSASTSASMSATTSASTSVSTSASTSASTSASTSSSSSVTSNSSKEKVYSALPSTGDQDYSVTATALGLGLMTGATLLGRKKSKKDKD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280..----.....290.......300.......310.......320.......330.......340--....--....350...----....360.-.......370.....---..380.-----.--.--------.----...390.-.-----.....400.......410.......420.......430----.........440.......450.......460.......470.......480--.........490.......500.......510.......520.......530.......540.-...-...550.......560.....-..--570-..-.....580.......590.......600--.....-....610.......620.......630.------...-...640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQKTFG
K
Q
L
T
V
V
D
T
K
S
R
V
K
MHKSG
K
N
W
V
R
T
V
M
S
H
F
N
L
F
K
A
IKGR
A
T
V
E
A
D
V
C
I
Q
DV
E
K
EDRLSSG
N
L
T
Y
L
K
G
I
L
A
A
G
A
LVG
G
A
S
L
T
S
R
VYADETPVVQEQSSSVPTLAEQ
T
E
V
T
V
K
T
T
T
VQNHQDGTVSKNIIDSNSVSMSESASTSTS
E
S
V
S
M
SMSGS
T
L
T
S
V
S
E
S
V
S
T
S
A
L
TS
A
S
ESISTSASESVSKST
S
I
S
E
V
S
N
I
L
E
T
Q
ASLTDKGRESFSAN
Q
I
V
TESSLVTDAGKNA
S
V
S
S
L
I
E
ITK
P
K
S
E
L
Q
T
SKMSNESLITPEK
S
Q
V
M
I
A
SDKTGNESL
T
P
T
I
----
R
L
KSVIQPRS
M
N
L
M
T
LSSEMD
L
I
PLEEVS
D
T
E
M
L
G
K
D
V
S
S
E
L
Q
K
V
N
I
A
L
KDNTLSEP---
G
T
V
K
--LDSSE
N
L
V
L
N
----
F
A
F
S
I
A
-S-VNEG
D
V
F
T
V
KLSDNL---DTQG
I
G
-----
T
--
I
--------
L
----
K
V
Q
D
I
M
D-E-----TG
Q
L
L
ATGSYSP
L
T
H
N
I
T
Y
T
W
T
R
Y
A
S
T
L
N
N
I
K
A
RVN------MPVWPD
Q
R
I
I
SKTTSD
K
Q
C
F
T
ATLNN
Q
V
A
S
I
E
E
R
VQYNSPSVTEHTN
V
K
T
----
N
V
R
S
R
I
M
KLDDERQT
E
T
Y
I
T
Q
INPEG
K
E
M
Y
F
ASGLG
N
L
Y
T
I
I
GSDGTSGS
P
V
N
L
L
N
A
E
V
K
I
L
K-TNS-KNLT
D
S
MDQNYDSP
E
F
E
D
V
T
S
-QY--SYT-ND-G
S
K
I
T
I
D
W
KTNSISST
T
S
Y
V
V
L
V
K
IP----KQS
G
V
-
L
Y
S
T
V
S
D
I
N
Q
T
YGSKYSYGHTNISGDSD------AN
A
-
E
I
K
L
L
SESASTSASTSASTSASMSASTSASTSASMSASTSASTSASMSASTSASTSASTSTSTSASTSASTSASTSASMSASTSASTSASTSASTSASTSASTSASTSASTSASTSASTSASTSASTSASTSASTSASTSAS
M
S
ASMSASTSASMSASTSASTSASTSASTSASTSASTSASMSASTSASTSASTSASMSASTSASTSASTSASTSASTSTSTSASTSASTSASTSASMSASTSASTSPSTSASTSASTSASTSASTSASTSASMSASTSASTSASMSASTSASTSASTSASTSASMSASTSASTSASTSASMSASTSASTSASTSASTSASTSTSTSASTSASTSASTSASMSASTSASTSASTSASMSAST
S
A
S
I
SASTSASMSASTSASTSASTSASTSASMSASTSASTSASTSASTSASMSASTSASTSASTSASTSASTSASTSASTSASTSSSTSASTSASTSASTSASMSASTSASTSASMSASTSASTSASTS
A
S
M
SASTSSSTSASMSASTSASMSASTSASTSASTS
A
S
M
SASTSSSTSASMSASTSASMSASTSASTSASTSASMSASTSAS
M
S
ATTSAS
T
S
V
STSASTSASTSASTSSSSSVTSNS
S
K
E
K
V
Y
S
ALPSTGDQD
Y
S
V
T
A
T
A
L
G
L
G
L
M
T
G
A
T
L
LGRKKSKKDKD
2
PsiBlast_PDB
90.95
37%
-42
- C10 -
4MBR
-
?
A:
[20-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
D
V
T
D
K
L
Q
N
L
D
I
K
L
S
G
G
V
Q
A
K
A
---
G
V
I
N
--
M
D
K
S
E
S
M
H
M
S
----
L
K
F
T
I
D
-
S
-
V
N
R
G
D
T
F
E
I
K
L
S
D
N
I
---
D
T
N
G
A
S
-----
N
--
Y
--------
S
----
I
V
E
P
I
K
S
-
P
-----
T
G
E
V
Y
A
T
G
I
Y
D
S
Q
K
K
S
I
V
Y
S
F
T
D
F
A
A
S
K
N
N
I
N
G
I
L
D
------
I
P
L
W
P
D
D
T
T
V
Q
N
T
K
E
D
-
V
L
F
S
V
K
I
K
D
Q
E
A
T
I
K
E
T
V
K
Y
D
P
P
V
R
I
D
F
A
G
-
G
V
----
S
V
D
S
R
I
T
N
I
D
D
V
G
K
K
M
T
Y
I
S
Q
I
N
V
D
G
K
S
L
Y
N
Y
N
G
---
L
Y
T
R
I
-
Y
N
Y
S
K
E
S
T
A
D
L
K
N
S
T
I
K
I
Y
K
-
T
T
S
-
D
N
I
V
E
S
M
V
Q
D
Y
S
S
--
M
E
D
V
T
S
-
K
F
AN
S
Y
P
-
E
K
-
G
W
-
Y
D
I
Y
W
-
G
Q
F
I
A
S
N
E
T
Y
V
I
V
V
E
T
P
----
F
T
N
A
V
T
L
N
T
T
L
S
D
Y
N
E
N
N
G
V
E
H
N
H
T
Y
S
S
E
S
G
Y
S
D
------
V
N
A
Q
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
79.38
100%
-40
- C10 -
4RMB
-
?
A:
[10-158]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
E
T
Y
I
T
Q
I
N
P
E
G
K
E
M
Y
F
A
S
G
L
G
N
L
Y
T
I
I
G
S
D
G
---
S
P
V
N
L
L
N
A
E
V
K
I
L
K
-
T
N
S
-
K
N
L
T
-----
N
Y
D
S
P
E
F
E
D
V
T
S
-
Q
Y
--
S
Y
T
-
N
D
-
G
S
K
I
T
I
D
W
K
T
N
S
I
S
S
T
T
S
Y
V
V
L
V
K
I
P
----
K
Q
S
G
V
-
L
Y
S
T
V
S
D
I
N
Q
T
Y
G
S
K
Y
S
Y
G
H
T
N
I
S
G
D
S
D
------
A
N
A
-
E
I
K
L
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.35
100%
-39
- C10 -
4RMB
-
?
A:
[10-158]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
E
T
Y
I
T
Q
I
N
P
E
G
K
E
M
Y
F
A
S
G
L
G
N
L
Y
T
I
I
G
S
D
---
G
S
P
V
N
L
L
N
A
E
V
K
I
L
K
-
T
N
S
-
K
N
L
T
-----
N
Y
D
S
P
E
F
E
D
V
T
S
-
Q
Y
--
S
Y
T
-
N
D
-
G
S
K
I
T
I
D
W
K
T
N
S
I
S
S
T
T
S
Y
V
V
L
V
K
I
P
----
K
Q
S
G
V
-
L
Y
S
T
V
S
D
I
N
Q
T
Y
G
S
K
Y
S
Y
G
H
T
N
I
S
G
D
S
D
------
A
N
A
-
E
I
K
L
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
77.69
21%
-14
* C10 *
1N67
3
CLFA_STAAE
A:
[28-359]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
D
I
T
N
Q
L
T
N
V
T
V
G
I
D
S
G
T
--------
T
V
Y
--
P
H
Q
A
G
Y
V
K
L
N
----
Y
G
F
S
V
P
N
S
-
A
V
K
G
D
T
F
K
I
T
V
P
K
E
L
---
N
L
N
G
V
T
-----
S
--
T
--------
A
----
K
V
P
P
-
I
M
-
A
-----
G
D
Q
V
L
A
N
G
V
I
D
S
-
D
G
N
V
I
Y
T
F
T
D
Y
V
N
T
K
D
D
V
K
A
T
L
T
------
M
P
A
Y
I
D
P
E
N
V
K
K
T
G
--
N
V
T
L
A
T
G
I
G
S
T
T
A
N
K
T
V
L
V
D
Y
E
K
Y
G
K
F
Y
----
N
L
----
S
I
K
G
T
I
D
Q
I
D
K
T
N
N
T
Y
R
Q
T
I
Y
V
N
P
S
G
D
N
V
I
A
P
V
L
T
G
N
L
----
K
P
N
T
D
S
N
A
L
I
D
Q
Q
N
T
S
I
K
V
Y
K
V
D
N
A
-
A
D
L
S
E
S
Y
--
F
V
N
P
E
N
F
E
D
V
T
N
-
S
V
--
N
I
T
-
F
P
N
P
N
Q
Y
K
V
E
F
N
T
P
D
D
Q
I
T
T
P
Y
I
V
V
V
N
G
H
I
DPN
S
K
G
D
L
-
A
L
R
S
T
L
Y
G
Y
N
S
N
I
I
W
R
S
M
S
W
D
N
E
V
A
F
N
N
------
G
S
G
-
S
G
D
G
I
D
K
P
V
V
P
E
Q
P
D
E
P
G
E
I
E
P
I
P
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
72.20
24%
-40
- C10 -
1N67
3
CLFA_STAAE
A:
[28-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
D
I
T
N
Q
L
T
N
V
T
V
G
I
D
S
G
T
T
--------
V
Y
--
P
H
Q
A
G
Y
V
K
L
N
----
Y
G
F
S
V
P
N
S
-
A
V
K
G
D
T
F
K
I
T
V
P
K
E
L
---
N
L
N
G
V
T
-----
S
--
T
--------
A
----
K
V
-
P
P
I
M
-
A
-----
G
D
Q
V
L
A
N
G
V
I
D
S
D
-
G
N
V
I
Y
T
F
T
D
Y
V
N
T
K
D
D
V
K
A
T
L
T
------
M
P
A
Y
I
D
P
E
N
V
K
K
T
--
G
N
V
T
L
A
T
G
I
G
S
T
T
A
N
K
T
V
L
V
D
Y
E
K
Y
G
K
----
F
Y
N
L
----
S
I
K
G
T
I
D
Q
I
D
K
T
N
N
T
Y
R
Q
T
I
Y
V
N
P
S
G
D
N
V
I
A
----
P
V
L
T
G
N
L
K
P
N
T
D
S
N
A
L
I
D
Q
Q
N
T
S
I
K
V
Y
K
-
V
D
N
A
A
D
L
S
E
S
Y
F
V
N
--
P
E
N
F
E
D
V
T
N
-
S
V
--
N
I
T
F
P
N
-
P
N
Q
Y
K
V
E
F
N
T
P
D
D
Q
I
T
T
P
Y
I
V
V
V
N
G
H
----
I
D
P
N
S
-
K
G
D
L
A
L
R
S
T
L
Y
G
Y
N
S
N
I
I
W
R
S
M
S
W
D
N
E
V
------
A
F
N
-
N
G
S
G
S
G
D
G
I
D
K
P
V
V
P
E
Q
P
D
E
P
G
E
I
E
P
I
P
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
62.24
21%
-36
- C10 -
3IRP
2
X:
[4-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
R
N
V
N
H
L
V
F
A
N
T
S
Y
E
I
L
G
G
G
K
K
Y
---
N
Q
V
F
--
M
T
M
D
G
K
L
K
I
K
----
I
D
Y
T
V
D
D
S
-
V
V
E
G
D
Y
F
T
V
D
F
G
K
Y
I
---
H
P
G
T
S
R
-----
K
--
P
--------
Y
----
R
V
N
N
I
H
D
-
A
-----
N
G
R
T
I
A
I
G
S
Y
D
S
A
T
N
T
A
K
Y
T
F
T
N
Y
V
D
I
Y
N
N
V
R
G
S
F
S
------
L
L
S
W
P
F
K
E
L
V
T
T
D
K
Q
-
S
V
P
V
G
I
T
V
A
G
E
D
Y
T
Q
N
V
I
F
N
Y
G
N
R
T
V
-
P
-----------
V
I
S
D
I
N
Y
L
T
-
K
-
D
F
A
E
F
T
T
Y
I
N
Q
N
R
A
F
N
T
G
S
----
K
V
-
R
L
S
G
Q
----
G
F
-
K
F
T
S
P
D
E
I
E
V
Y
K
-
V
L
N
N
S
Q
F
R
D
S
F
S
P
D
--
Y
A
N
L
T
Q
V
R
N
P
K
I
--
I
I
N
-
S
D
-
G
-
S
A
T
V
D
L
G
D
--
I
G
-
T
L
G
Y
I
I
R
S
K
P
N
----
T
L
P
D
F
-
S
G
I
G
V
L
K
S
E
Y
T
F
T
N
N
K
N
Q
R
D
T
R
A
H
A
S
S
I
------
Q
F
V
-
R
A
E
L
A
G
F
G
G
F
G
G
Y
V
W
F
D
K
N
N
D
G
V
Q
N
D
S
N
A
A
A
A
G
I
T
V
N
L
L
D
P
T
G
I
R
L
A
T
T
T
T
D
I
T
G
H
Y
N
F
D
N
L
T
N
G
N
Y
L
V
E
F
V
M
P
E
G
Y
I
P
T
Q
A
N
S
T
V
D
D
K
D
S
D
V
V
F
E
N
G
R
Y
I
A
H
V
T
I
K
D
A
D
N
M
T
I
D
A
G
L
V
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
59.19
19%
29
- C11 -
4QTS
-
CSM4_METJA
A:
[1-369]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
M
V
V
L
K
P
K
I
N
S
K
F
H
F
K
I
F
H
S
N
S
L
F
S
A
I
V
N
N
Y
I
K
L
Y
G
R
E
D
L
E
K
N
I
E
K
I
K
N
I
R
L
S
S
L
--
L
Y
K
I
K
N
I
Y
L
I
P
K
P
E
H
P
E
F
Y
P
K
D
I
K
K
I
Q
F
F
S
I
K
A
Y
K
E
L
L
D
N
E
L
DWKN
K
I
K
H
I
V
D
Y
Q
T
I
N
K
S
I
V
I
S
E
K
E
I
E
E
I
K
R
I
F
G
I
K
------
A
E
K
L
K
H
A
K
I
S
L
I
S
K
H
L
E
Q
K
---
V
A
D
K
G
Q
L
Y
N
I
E
F
I
K
L
N
EN
V
E
F
Y
F
L
I
D
-
Y
-
N
N
E
D
K
E
F
I
K
K
L
E
A
S
I
K
L
I
E
D
E
G
L
G
GAGFF
E
--
K
--------
V
----
E
I
V
D
L
P
E
-
D
-----
F
N
E
I
L
D
E
N
S
---
K
Y
N
N
L
E
Y
K
M
L
L
G
V
G
I
P
N
--
K
D
D
I
K
------
N
I
E
Y
Y
K
L
I
E
I
G
G
Y
I
Y
S
L
E
C
L
T
K
P
K
R
N
I
L
A
L
T
E
G
S
I
V
K
N
D
F
-
I
G
D
V
K
D
V
Y
T
----
H
G
K
P
I
L
L
P
F
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
54.77
31%
-6
- C10 -
2RAL
-
SDRG_STAEP
A:
[299-389]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
I
K
--
A
H
D
A
E
N
L
I
Y
D
----
V
T
F
E
V
D
-
D
K
V
K
S
G
D
T
M
T
V
N
I
D
K
N
T
---
V
P
S
D
L
T
-----
D
--
S
--------
F
----
A
I
P
K
I
K
D
-
N
-----
S
G
E
I
I
A
T
G
T
Y
D
N
T
N
K
Q
I
T
Y
T
F
T
D
Y
V
D
K
Y
C
N
I
K
A
H
L
K
------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
54.58
30%
-36
- C10 -
2VR3
1
CLFA_STAA8
A:
[15-131]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
N
Q
L
T
N
V
T
V
G
I
D
S
G
T
T
V
Y
P
HQA
G
Y
V
K
--
L
--------
N
----
Y
G
F
S
V
P
N
S
-
A
V
K
G
D
T
F
K
I
T
V
P
K
E
L
---
N
L
N
G
V
T
-----
S
--
T
--------
A
----
K
V
P
P
I
M
--
A
--------
V
L
A
N
G
V
I
D
-
S
D
G
N
V
I
Y
T
F
T
D
Y
V
N
T
K
C
D
V
K
A
T
L
T
------
M
P
A
Y
I
D
P
E
N
V
K
K
T
G
N
V
T
L
A
T
G
I
G
S
T
T
A
N
K
T
V
L
V
D
Y
E
K
Y
G
K
F
Y
N
L
S
I
K
G
T
I
----
D
Q
I
D
K
T
N
N
T
Y
R
Q
T
I
Y
V
N
P
S
G
D
N
V
I
A
P
V
L
T
G
N
L
K
P
N
T
D
S
N
A
L
I
D
Q
Q
N
T
S
I
K
V
Y
K
V
D
N
A
A
D
L
S
E
S
-
Y
F
V
-
N
P
E
D
V
T
N
S
V
N
I
T
F
P
N
P
N
Q
Y
K
V
-
E
F
--
P
D
D
-
Q
I
-
T
T
P
Y
I
V
V
V
N
G
H
I
D
P
N
S
K
G
D
L
A
L
R
S
T
L
----
Y
G
Y
N
S
-
N
I
I
W
R
S
M
S
W
D
N
E
V
A
F
N
N
G
S
G
S
G
D
G
I
D
C
P
------
V
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
54.50
31%
-36
- C10 -
1N67
2
A:
[28-146]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
D
I
T
N
Q
L
T
N
V
T
V
G
I
D
S
G
T
T
V
Y
P
HQA
G
Y
V
K
--
L
--------
N
----
Y
G
F
S
V
P
N
S
-
A
V
K
G
D
T
F
K
I
T
V
P
K
E
L
---
N
L
N
G
V
T
-----
S
--
T
--------
A
----
K
V
P
P
I
M
--
A
-----
G
D
Q
V
L
A
N
G
V
I
D
-
S
D
G
N
V
I
Y
T
F
T
D
Y
V
N
T
K
D
D
V
K
A
T
L
T
------
M
P
A
Y
I
D
P
E
N
V
K
K
T
G
N
V
T
L
A
T
G
I
G
S
T
T
A
N
K
T
V
L
V
D
Y
E
K
Y
G
K
F
Y
N
L
S
I
K
G
T
I
----
D
Q
I
D
K
T
N
N
T
Y
R
Q
T
I
Y
V
N
P
S
G
D
N
V
I
A
P
V
L
T
G
N
L
K
P
N
T
D
S
N
A
L
I
D
Q
Q
N
T
S
I
K
V
Y
K
V
D
N
A
A
D
L
S
E
S
-
Y
F
V
-
N
P
E
N
F
E
D
V
T
N
S
V
N
I
T
F
P
N
P
N
Q
-
Y
K
--
V
E
F
-
N
T
-
P
D
D
Q
I
T
T
P
Y
I
V
V
V
N
G
H
I
D
P
N
S
K
G
D
L
A
----
L
R
S
T
L
-
Y
G
Y
N
S
N
I
I
W
R
S
M
S
W
D
N
E
V
A
F
N
N
G
S
G
S
G
D
------
G
I
D
-
K
P
V
V
P
E
Q
P
D
E
P
G
E
I
E
P
I
P
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
52.66
12%
21
- C10 -
3IRP
7
UAFA_STAS1
X:
[2-419]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
S
G
R
N
V
N
H
L
V
F
A
N
T
S
Y
E
I
L
G
G
G
K
K
Y
---
N
Q
V
F
--
M
T
M
D
G
K
L
K
I
K
----
I
D
Y
T
V
D
-
D
S
V
V
E
G
D
Y
F
T
V
D
F
G
K
Y
I
---
H
P
G
T
S
R
-----
K
--
P
--------
Y
----
R
V
N
N
I
H
D
-
A
-----
N
G
R
T
I
A
I
G
S
Y
D
S
A
T
N
T
A
K
Y
T
F
T
N
Y
V
D
I
Y
N
N
V
R
G
S
F
S
------
L
L
S
W
P
F
K
E
L
V
-
T
T
D
K
Q
S
V
P
V
G
I
T
V
A
G
E
D
Y
T
Q
N
V
I
F
N
Y
G
N
R
T
V
P
V
I
S
D
I
N
Y
LTKD
F
A
E
F
T
T
Y
I
N
Q
N
R
A
F
N
T
G
S
K
V
R
L
S
G
Q
G
F
K
F
T
S
P
D
E
I
E
V
Y
K
V
L
N
N
S
Q
F
R
D
S
F
S
P
D
Y
A
N
L
T
Q
V
R
N
P
-
K
I
I
-
I
N
S
D
G
S
A
T
V
D
L
G
D
I
G
T
L
G
Y
I
I
-
R
S
--
K
P
N
-
T
L
-
P
D
F
S
G
I
G
V
L
K
S
E
Y
T
F
T
N
N
K
N
Q
R
D
T
R
A
----
H
A
S
S
I
-
Q
F
V
R
A
E
L
A
G
F
G
G
F
G
G
Y
V
W
F
D
K
N
N
D
G
V
Q
N
DSNAAA
A
G
I
-
T
V
N
L
L
D
P
T
G
I
R
L
A
T
T
T
T
D
I
T
G
H
Y
N
F
D
N
L
T
N
G
N
Y
L
V
E
F
V
M
P
E
G
Y
I
P
T
-
Q
A
N
S
T
V
D
D
K
D
S
D
V
V
F
E
N
G
R
Y
I
A
H
V
T
I
K
D
A
D
N
M
T
I
D
A
G
L
V
S
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
52.52
28%
-9
- C10 -
4B5Z
-
A:
[42-153]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
----
Y
K
L
K
F
E
-
N
G
L
H
Q
G
D
Y
F
D
F
T
L
S
N
N
V
---
N
T
H
G
V
S
-----
T
--
A
--------
R
----
K
V
P
E
I
K
N
-
G
SVVM
A
T
G
E
V
L
E
G
G
K
-------
I
R
Y
T
F
T
------
N
D
I
E
D
K
V
D
V
T
A
E
L
E
I
N
L
F
I
D
P
K
T
V
Q
--
T
N
G
N
Q
T
I
T
S
T
L
N
E
E
Q
T
S
K
E
L
D
V
K
Y
K
D
G
I
G
N
Y
Y
A
N
L
N
G
----
S
I
E
T
F
N
K
A
N
N
R
F
S
H
V
A
F
I
K
P
N
N
G
K
T
T
S
V
T
V
T
G
T
L
M
K
G
S
N
Q
N
G
N
Q
P
K
V
R
I
F
E
Y
L
G
N
N
E
D
I
A
K
S
V
-
Y
A
N
-
T
T
D
T
S
K
F
K
E
V
T
S
N
M
S
G
N
L
N
L
Q
-
N
N
--
G
S
Y
-
S
L
-
N
I
E
N
L
D
K
T
Y
V
V
H
Y
D
G
E
Y
L
N
G
T
D
E
V
D
F
----
R
T
Q
M
V
-
G
H
P
E
Q
L
Y
K
Y
Y
Y
D
R
G
Y
T
L
T
W
D
N
G
L
V
L
Y
S
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
52.51
29%
8
- C10 -
4JDZ
-
?
B:
[47-150]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
Y
F
T
I
K
Y
S
D
T
V
---
Q
V
Y
G
L
N
-----
P
ED
I
--------
K
----
N
I
G
D
I
K
D
P
N
-----
N
G
E
T
I
A
T
A
K
H
D
T
A
N
N
L
I
T
Y
T
F
T
D
Y
V
D
R
F
N
S
V
Q
M
G
I
N
------
Y
S
I
Y
M
D
A
D
T
I
P
V
S
K
N
D
V
E
-
F
N
V
T
I
G
N
D
T
T
K
T
T
A
N
I
Q
Y
P
D
Y
V
S
R
D
N
N
S
I
G
S
----
A
F
T
E
T
V
S
H
A
G
N
A
E
D
P
G
Y
Y
K
Q
T
V
Y
V
N
P
S
E
K
S
L
T
N
A
K
L
K
V
E
A
Y
H
K
D
Y
P
D
N
V
G
Q
I
N
K
D
V
T
K
I
K
I
Y
Q
-
A
P
K
-
D
Y
V
L
N
K
G
Y
D
V
N
T
N
Q
L
I
D
V
T
E
Q
-
F
K
--
D
K
I
-
T
Y
-
G
A
N
D
S
V
N
V
D
F
G
S
I
N
N
S
Y
V
V
M
V
D
T
K
F
E
----
Y
T
T
S
A
-
S
P
T
L
V
Q
M
A
T
L
T
S
D
G
N
R
S
V
S
T
G
N
A
L
G
F
T
N
------
N
Q
S
-
G
G
A
A
Q
E
V
Y
K
I
G
N
Y
V
W
E
D
T
N
K
N
G
V
Q
D
L
G
E
V
G
V
K
G
V
T
V
V
A
Y
D
N
A
A
A
A
E
V
G
R
T
I
T
D
D
K
G
G
Y
L
I
P
N
L
P
N
G
D
Y
R
V
E
F
S
N
L
P
Q
G
Y
E
V
T
P
S
K
Q
G
N
N
E
E
L
D
S
N
G
V
S
S
V
I
T
V
N
G
K
D
N
L
S
A
D
L
G
I
Y
K
P
K
Y
N
L
G
D
Y
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
52.37
29%
14
- C10 -
4JE0
-
?
A:
[51-154]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
Y
F
T
I
K
Y
S
D
T
V
---
Q
V
Y
G
L
N
-----
P
ED
I
--------
K
----
N
I
G
D
I
K
D
P
N
-----
N
G
E
T
I
A
T
A
K
H
D
T
A
N
N
L
I
T
Y
T
F
T
D
Y
V
D
R
F
N
S
V
Q
M
G
I
N
------
Y
S
I
Y
M
D
A
D
T
I
P
V
S
K
N
D
V
E
-
F
N
V
T
I
G
N
D
T
T
K
T
T
A
N
I
Q
Y
P
D
Y
V
S
R
D
N
N
S
I
G
S
----
A
F
T
E
T
V
S
H
A
G
N
A
E
D
P
G
Y
Y
K
Q
T
V
Y
V
N
P
S
E
K
S
L
T
N
A
K
L
K
V
E
A
Y
H
K
D
Y
P
D
N
V
G
Q
I
N
K
D
V
T
K
I
K
I
Y
Q
-
A
P
K
-
D
Y
V
L
N
K
G
Y
D
V
N
T
N
Q
L
I
D
V
T
E
Q
-
F
K
--
D
K
I
-
T
Y
-
G
A
N
D
S
V
N
V
D
F
G
S
I
N
N
S
Y
V
V
M
V
D
T
K
F
E
----
Y
T
T
S
E
-
S
P
T
L
V
Q
M
A
T
L
T
S
D
G
N
R
S
V
S
T
G
N
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
52.26
32%
-21
- C10 -
1R17
2
SDRG_STAEP
A:
[44-134]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
I
K
--
A
H
D
A
E
N
L
I
Y
D
----
V
T
F
E
V
D
-
D
K
V
K
S
G
D
T
M
T
V
----
N
I
---
D
K
N
T
V
P
-----
S
--
D
--------
L
TD
S
F
A
I
P
K
I
K
D
-
N
-----
S
G
E
I
I
A
T
G
T
Y
D
N
T
N
K
Q
I
T
Y
T
F
T
D
Y
V
D
K
Y
E
N
I
K
A
H
L
K
------
L
T
S
Y
I
D
K
S
K
V
P
N
N
N
T
K
L
D
V
E
Y
K
T
A
L
S
S
V
N
K
T
I
T
V
E
Y
Q
K
P
N
E
N
R
T
A
N
L
Q
S
M
----
F
T
N
I
D
T
K
N
H
T
V
E
Q
T
I
Y
I
N
P
L
R
Y
S
A
K
E
T
N
V
N
I
S
G
N
G
D
E
G
S
T
I
I
D
D
S
T
I
I
K
V
Y
K
V
G
D
N
Q
N
L
P
D
S
N
-
R
I
Y
-
D
Y
S
E
Y
E
D
V
T
N
D
D
Y
A
Q
L
G
N
N
N
D
-
V
N
--
I
N
F
-
G
N
-
I
D
S
P
Y
I
I
K
V
I
S
K
Y
D
P
N
K
D
D
Y
T
T
I
Q
Q
T
----
V
T
M
Q
T
-
T
I
N
E
Y
T
G
E
F
R
T
A
S
Y
D
N
T
I
A
F
S
T
S
S
G
Q
G
Q
------
G
D
L
-
P
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
51.88
32%
-28
- C10 -
1R17
3
B:
[44-134]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
I
K
--
A
H
D
A
E
N
L
I
Y
D
----
V
T
F
E
V
D
-
D
K
V
K
S
G
D
T
M
T
V
----
N
I
---
D
K
N
T
V
P
-----
S
--
D
--------
L
TDSF
A
I
P
K
I
K
D
-
N
-----
S
G
E
I
I
A
T
G
T
Y
D
N
T
N
K
Q
I
T
Y
T
F
T
D
Y
V
D
K
Y
E
N
I
K
A
H
L
K
------
L
T
S
Y
I
D
K
S
K
V
P
N
N
N
T
K
L
D
V
E
Y
K
T
A
L
S
S
V
N
K
T
I
T
V
E
Y
Q
K
P
N
E
N
R
T
A
N
L
Q
S
M
----
F
T
N
I
D
T
K
N
H
T
V
E
Q
T
I
Y
I
N
P
L
R
Y
S
A
K
E
T
N
V
N
I
S
G
N
G
D
E
G
S
T
I
I
D
D
S
T
I
I
K
V
Y
K
V
G
D
N
Q
N
L
P
D
S
N
-
R
I
Y
-
D
Y
S
E
Y
E
D
V
T
N
D
D
Y
A
Q
L
G
N
N
N
D
-
V
N
--
I
N
F
-
G
N
-
I
D
S
P
Y
I
I
K
V
I
S
K
Y
D
P
N
K
D
D
Y
T
T
I
Q
Q
T
----
V
T
M
Q
T
-
T
I
N
E
Y
T
G
E
F
R
T
A
S
Y
D
N
T
I
A
F
S
T
S
S
G
Q
G
Q
------
G
D
L
-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
51.53
28%
-3
- C10 -
4B60
1
FNBA_STAA8
A:
[42-153]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
----
Y
K
L
K
F
E
-
N
G
L
H
Q
G
D
Y
F
D
F
T
L
S
N
N
V
---
N
T
H
G
V
S
-----
T
--
A
--------
R
----
K
V
P
E
I
K
N
-
G
SVVM
A
T
G
E
V
L
E
G
G
K
-------
I
R
Y
T
F
T
------
N
D
I
E
D
K
V
D
V
T
A
E
L
E
I
N
L
F
I
D
P
K
T
V
Q
--
T
N
G
N
Q
T
I
T
S
T
L
N
E
E
Q
T
S
K
E
L
D
V
K
Y
K
D
G
I
G
N
Y
Y
A
N
L
N
G
----
S
I
E
T
F
N
K
A
N
N
R
F
S
H
V
A
F
I
K
P
N
N
G
K
T
T
S
V
T
V
T
G
T
L
M
K
G
S
N
Q
N
G
N
Q
P
K
V
R
I
F
E
Y
L
G
N
N
E
D
I
A
K
S
V
-
Y
A
N
-
T
T
D
T
S
K
F
K
E
V
T
S
N
M
S
G
N
L
N
L
Q
-
N
N
--
G
S
Y
-
S
L
-
N
I
E
N
L
D
K
T
Y
V
V
H
Y
D
G
E
Y
L
N
G
T
D
E
V
D
F
----
R
T
Q
M
V
-
G
H
P
E
G
Y
T
L
T
W
D
N
G
L
V
L
Y
S
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
50.38
30%
21
- C10 -
3AU0
-
A:
[52-129]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
Y
F
T
A
K
L
P
D
S
L
-----
T
G
N
G
-----
D
--
V
DYSNSNN
T
M
----
P
I
A
D
I
K
S
-
T
-----
N
G
D
V
V
A
K
A
T
Y
D
I
L
T
K
T
Y
T
F
V
F
T
D
Y
V
N
N
K
E
N
I
N
G
Q
F
S
------
L
P
L
F
T
D
R
A
K
A
P
K
S
G
T
Y
D
A
N
I
N
I
A
D
E
M
F
N
N
K
I
T
Y
N
Y
S
S
P
I
A
G
I
D
K
P
N
G
A
N
I
----
S
S
Q
I
I
G
V
D
T
A
S
G
Q
N
T
Y
K
Q
T
V
F
V
N
P
K
Q
R
V
L
G
N
T
W
V
Y
I
K
G
Y
Q
D
K
I
E
E
S
S
G
K
V
S
A
T
D
T
K
L
R
I
F
E
V
N
-
D
T
S
-
K
L
S
E
S
Y
Y
A
D
P
N
D
S
N
L
K
E
V
T
D
Q
-
F
K
--
N
R
I
-
Y
Y
-
E
H
P
N
V
A
S
I
K
F
G
D
I
T
K
T
Y
V
V
L
V
E
G
H
Y
D
----
N
T
G
K
N
-
L
K
T
Q
V
I
Q
E
N
V
D
P
V
T
N
R
D
Y
S
I
F
G
W
N
N
E
N
V
------
V
R
Y
-
G
G
G
S
A
D
G
D
S
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
50.35
30%
14
- C10 -
3ASW
1
A:
[51-128]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
Y
F
T
A
K
L
P
D
S
L
-----
T
G
N
G
-----
D
--
V
DYSNSNN
T
M
----
P
I
A
D
I
K
S
-
T
-----
N
G
D
V
V
A
K
A
T
Y
D
I
L
T
K
T
Y
T
F
V
F
T
D
Y
V
N
N
K
E
N
I
N
G
Q
F
S
------
L
P
L
F
T
D
R
A
K
A
P
K
S
G
T
Y
D
A
N
I
N
I
A
D
E
M
F
N
N
K
I
T
Y
N
Y
S
S
P
I
A
G
I
D
K
P
N
G
A
N
I
----
S
S
Q
I
I
G
V
D
T
A
S
G
Q
N
T
Y
K
Q
T
V
F
V
N
P
K
Q
R
V
L
G
N
T
W
V
Y
I
K
G
Y
Q
D
K
I
E
E
S
S
G
K
V
S
A
T
D
T
K
L
R
I
F
E
V
N
-
D
T
S
-
K
L
S
E
S
Y
Y
A
D
P
N
D
S
N
L
K
E
V
T
D
Q
-
F
K
--
N
R
I
-
Y
Y
-
E
H
P
N
V
A
S
I
K
F
G
D
I
T
K
T
Y
V
V
L
V
E
G
H
Y
D
----
N
T
G
K
N
-
L
K
T
Q
V
I
Q
E
N
V
D
P
V
T
N
R
D
Y
S
I
F
G
W
N
N
E
N
V
------
V
R
Y
-
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
50.28
32%
-10
- C10 -
1R19
-
SDRG_STAEP
A:
[299-389]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
I
K
--
A
H
D
A
E
N
L
I
Y
D
----
V
T
F
E
V
D
-
D
K
V
K
S
--
T
M
T
V
----
N
I
---
D
K
N
T
V
P
-----
S
--
D
--------
L
TDSF-
I
P
K
I
K
---------
G
E
I
I
A
T
G
T
Y
D
N
T
N
K
Q
I
T
Y
T
-
T
D
Y
V
D
---
N
I
K
A
H
L
K
------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------