@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1531: (2015-12-08 )
MIDRKDTNRFKLVSKYSPSGDQPQAIETLVDNIEGGEKAQILKGATGTGKTYTMSQVIAQVNKPTLVIAHNKTLAGQLYGEFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYADSVVSLRPGQEISRDQLLNNLVDIQFERNDIDFQRGKFRVRGDVVEVFPASRDEHAFRIEFFGDEIDRIREIESLTGRVLGEVEHLAIFPATHFMTNDEHMEEAISKIQAEMENQVELFEKEGKLIEAQRIRQRTEYDIEMLREMGYTNGVENYSRHMDGRSEGEPPFTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDRSRKEMLVNYGFRLPSALDNRPLRREEFESHVHQIVYVSATPGDYEMEQTDTVVEQIIRPTGLLDPEVEVRPSMGQMDDLLGEINLRTEKGERTFITTLTKRMAEDLTDYLKEMGVKVKYMHSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSNGHVIMYADKITDSMQRAMDETARRRRLQMDYNEKHGIVPQTIKKEIRDLIAITKSNDSDKPEKVVDYSSLSKKERQAEIKALQQQMQEAAELLDFELAAQIRDVILELKAID
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.-.----.--.....70........80.....--...90......----..100.......110.......120.......130.......140......-.150.......160-.......170.--......180.......190.......200..-.....210.......220.......230........240.......250.......260.......270.......280.......290.......300.......310.......320.......330.....-..340.......350.......360......-.370.......380.......390........--.400.......410........420.......-430.......440.......450.......460.......470.......480...-......490.......500.......510.......520.-------......530.......540......-.550.......560.......570....-...580.......590.......600.......610.......620.......630----.......640.......650.......660.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIDRKDTN
R
F
K
L
V
S
KYSPSGDQ
P
Q
A
I
E
T
L
V
D
NIEGGEK
A
Q
I
L
KGATGTGKT
Y
T
M
S
Q
V
I
A
QVN-K----
P
--
T
L
V
I
AHNK
T
L
A
G
Q
L
Y
G
E
F
K
E
FF--PD
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
YQPEAYVPSSD
T
Y
IEKDSSV
N
D
E
I
D
K
L
R
H
S
A
T
S
S
L
LERN
D
V
I
V
V
A
S
V
S
-
C
I
YGLG
S
P
K
E
Y
A
D
S
-
V
VSLRPGQEI
S
--
R
D
Q
L
L
N
N
L
V
D
I
Q
F
ERNDIDFQR
G
K
F
R
V
RG
D
V
-
V
E
VFPASRDE
H
A
F
R
I
E
FFG
D
E
I
D
R
I
R
-
E
I
E
S
L
T
G
R
V
L
GEV
E
H
L
A
I
FP
A
T
HFMTN
D
E
H
M
E
E
A
I
S
K
I
Q
A
E
M
E
N
Q
V
E
L
F
E
KEGK
L
I
E
A
Q
R
I
R
Q
R
T
E
Y
D
I
E
M
L
R
EMGYTN
G
V
E
N
Y
S
R
HMDGRSEGEP
P
F
T
L
L
D
FFPE
D
-
F
L
I
M
I
DESHM
T
M
G
Q
I
K
G
MYNG
D
R
S
R
K
E
M
L
V
N
-YGFRLPSALDNRPL
R
R
E
E
F
E
S
H
--
V
H
Q
I
V
Y
V
S--ATPGDYEM
E
Q
T
D
T
-
V
V
E
Q
I
I
RPTGLLDPE
V
E
V-RPSMG
Q
M
D
D
L
L
G
E
I
N
L
RTEKGE
R
T
F
I
T
T
L
T
K
R
M
A
E
D
L
T
D
Y
L
K
EMG
V
K
V
K
Y
M
--
H
S
D
-
I
K
T
L
E
R
T
E
I
I
R
D
L
R
L
G
V
F
D
V
L
I
G
I
N
L
L
R
EGIDVP
E
V
S
L
V
A
-------
I
LDADKEGFLRNE
R
G
L
I
Q
T
I
G
R
A
AR-NSNG
H
V
I
M
Y
A
D
K
I
T
D
S
M
Q
R
A
M
D
E
T
A
R
R
R
-RLQMDYNEKHGI
V
P
Q
T
I
K
K
E
I
R
D
L
I
A
ITKSNDSDKPEKVV
D
Y
S
S
L
S
K
K
E
R
Q
A
E
I
K
A
----
L
Q
Q
Q
M
Q
E
A
A
E
L
L
D
F
E
L
A
A
Q
I
R
D
V
I
L
E
LKAID-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
90.51
68%
-91
- C4 -
2D7D
2
UVRB_BACSU
A:
[3-654]
-------
D
R
F
E
L
V
S
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
-
K
----
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
F
--
P
N
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
-
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
-
V
V
S
L
R
T
E
M
E
I
E
--
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
-
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
-
F
M
I
V
V
D
E
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
-
H
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
E
K
H
--
M
H
N
I
V
Y
V
S
--
A
T
P
G
P
Y
E
I
E
H
T
D
E
-
M
V
E
Q
I
I
R
P
T
G
L
L
D
P
L
I
D
V
-
R
P
I
E
G
Q
I
D
D
L
I
G
E
I
Q
A
R
I
E
R
N
E
R
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
N
Y
L
--
H
S
E
-
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
-
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
I
N
----------------------------
K
K
E
R
Q
K
V
V
E
Q
----
M
E
H
E
M
K
E
A
A
K
A
L
D
F
E
R
A
A
E
L
R
D
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
90.20
67%
-91
- C4 -
2D7D
2
UVRB_BACSU
A:
[3-654]
-------
D
R
F
E
L
V
S
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
-
K
----
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
F
--
P
N
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
-
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
-
V
V
S
L
R
T
E
M
E
I
E
--
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
-
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
-
F
M
I
V
V
D
E
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
-
H
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
E
K
H
--
M
H
N
I
V
Y
V
S
--
A
T
P
G
P
Y
E
I
E
H
T
D
E
-
M
V
E
Q
I
I
R
P
T
G
L
L
D
P
L
I
D
V
-
R
P
I
E
G
Q
I
D
D
L
I
G
E
I
Q
A
R
I
E
R
N
E
R
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
N
Y
L
--
H
S
E
-
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
-
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
I
N
----------------------------
K
K
E
R
Q
K
V
V
E
Q
----
M
E
H
E
M
K
E
A
A
K
A
L
D
F
E
R
A
A
E
L
R
D
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
89.22
67%
-89
- C4 -
2NMV
3
?
A:
[3-654]
-------
D
R
F
E
L
V
-
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
-
K
----
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
F
--
P
N
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
-
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
-
V
V
S
L
R
T
E
M
E
I
E
--
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
-
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
-
F
M
I
V
V
D
E
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
-
H
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
E
K
H
--
M
H
N
I
V
Y
V
S
--
A
T
P
G
P
Y
E
I
E
H
T
D
E
-
M
V
E
Q
I
I
R
P
T
G
L
L
D
P
L
I
D
V
-
R
P
I
E
G
Q
I
D
D
L
I
G
E
I
Q
A
R
I
E
R
N
E
R
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
N
Y
L
--
H
S
E
-
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
-
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
I
N
----------------------------
K
K
E
R
Q
K
V
V
E
Q
----
M
E
H
E
M
K
E
A
A
K
A
L
D
F
E
R
A
A
E
L
R
D
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
88.00
68%
-91
- C4 -
1T5L
2
UVRB_BACCA
B:
[3-595]
-------
G
R
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
-
K
----
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
--
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
A
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
-
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
V
S
L
R
V
G
M
E
I
E
--
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
D
F
R
R
G
T
F
R
V
R
G
D
V
-
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
-
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
-
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
--
I
N
Q
I
I
Y
V
S
--
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
-
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
E
R
V
E
R
N
E
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
--
H
S
E
-
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
-
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
87.68
68%
-89
- C4 -
3UWX
-
?
B:
[26-620]
-----
V
E
G
R
F
Q
L
V
S
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
L
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
-
K
----
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
H
S
E
L
K
E
F
F
--
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
-
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
V
S
L
R
V
G
M
E
I
E
--
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
D
F
R
R
G
T
F
R
V
R
G
D
V
-
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
-
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
-
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
--
I
N
Q
I
I
Y
I
S
--
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
-
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
H
E
R
V
E
R
N
E
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
--
H
S
E
-
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
-
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.56
68%
-89
- C4 -
1T5L
2
UVRB_BACCA
A:
[3-595]
-------
G
R
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
-
K
----
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
--
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
A
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
-
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
V
S
L
R
V
G
M
E
I
E
--
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
D
F
R
R
G
T
F
R
V
R
G
D
V
-
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
-
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
-
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
--
I
N
Q
I
I
Y
V
S
--
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
-
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
E
R
V
E
R
N
E
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
--
H
S
E
-
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
-
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.43
67%
-91
- C4 -
3V4R
2
UVRB_BACSU
A:
[9-596]
-------
D
R
F
E
L
V
S
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
-
K
----
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
F
--
P
N
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
-
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
-
V
V
S
L
R
T
E
M
E
I
E
--
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
-
V
E
I
F
P
--
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
-
F
M
I
V
V
D
E
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
-
H
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
E
K
H
--
M
H
N
I
V
Y
V
S
--
A
T
P
G
P
Y
E
I
E
H
T
D
E
-
M
V
E
Q
I
I
R
P
T
G
L
L
D
P
L
I
D
V
-
R
P
I
E
G
Q
I
D
D
L
I
G
E
I
Q
A
R
I
E
R
N
E
R
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
N
Y
L
--
H
S
E
-
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
-
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
I
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
86.26
68%
-89
- C4 -
2FDC
2
UVRB_BACCA
B:
[3-593]
-------
G
R
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
-
K
----
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
--
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
-
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
V
S
L
R
V
G
M
E
I
E
--
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
D
F
R
R
G
T
F
R
V
R
G
D
V
-
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
-
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
-
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
--
I
N
Q
I
I
Y
V
S
--
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
-
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
E
R
V
E
R
N
E
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
--
H
---------
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
-
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
86.01
67%
-91
- C4 -
3V4R
2
?
B:
[9-595]
-------
D
R
F
E
L
V
S
K
Y
Q
P
Q
G
D
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
-
K
----
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
F
--
P
N
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
-
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
-
V
V
S
L
R
T
E
M
E
I
E
--
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
-
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
-
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
--------
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
-
F
M
I
V
V
D
E
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
-
H
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
E
K
H
--
M
H
N
I
V
Y
V
S
--
A
T
P
G
P
Y
E
I
E
H
T
D
E
-
M
V
E
Q
I
I
R
P
T
G
L
L
D
P
L
I
D
V
-
R
P
I
E
G
Q
I
D
D
L
I
G
E
I
Q
A
R
I
E
R
N
E
R
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
N
Y
L
--
H
S
E
-
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
-
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
K
T
I
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Fugue
85.52
71%
-77
- C4 -
1D9X
2
UVRB_BACCA
A:
[2-595]
------
E
G
R
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
-
K
----
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
--
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
-
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
V
S
L
R
V
G
M
E
I
E
--
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
--
F
R
G
T
F
R
V
R
G
D
V
-
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
A
---
E
V
D
A
L
T
G
K
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
-
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
-
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
--
I
N
Q
I
I
Y
V
S
--
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
-
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
E
R
V
E
R
N
E
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
--
H
S
E
-
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
N
A
-
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
-
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.45
68%
-78
- C4 -
1D9X
2
UVRB_BACCA
A:
[3-595]
-------
G
R
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
-
K
----
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
--
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
-
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
V
S
L
R
V
G
M
E
I
E
--
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
-
F
-
R
G
T
F
R
V
R
G
D
V
-
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
---A
E
V
D
A
L
T
G
K
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
-
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
-
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
--
I
N
Q
I
I
Y
V
S
--
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
-
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
E
R
V
E
R
N
E
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
--
H
S
E
-
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
-
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.68
68%
-75
- C4 -
1D9Z
4
UVRB_BACCA
A:
[3-594]
-------
G
R
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
-
K
----
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
--
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
-
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
V
S
L
R
V
G
M
E
I
E
--
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
-
F
-
R
G
T
F
R
V
R
G
D
V
-
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
--
R
-
E
V
D
A
L
T
G
K
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
-
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
-
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
--
I
N
Q
I
I
Y
V
S
--
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
-
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
E
R
V
E
R
N
E
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
--
H
S
E
-
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
-
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.63
68%
-86
- C4 -
2FDC
1
UVRB_BACCA
A:
[3-594]
-------
G
R
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
-
K
----
P
--
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
--
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
-
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
V
---------------------------------------------------------------------------------------
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
-
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
-
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
--
I
N
Q
I
I
Y
V
S
--
A
T
P
G
P
Y
E
L
E
H
S
P
G
-
V
V
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
-
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
E
R
V
E
R
N
E
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
--
H
-------
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
-
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Fugue
81.68
58%
-81
- C4 -
1D2M
4
UVRB_THET8
A:
[2-583]
--------
T
F
R
Y
-
R
G
P
S
P
K
G
D
Q
P
K
A
I
A
G
L
V
E
A
L
R
D
G
E
R
F
V
T
L
L
G
A
T
G
T
G
K
T
V
T
M
A
K
V
I
E
A
L
G
-
R
----
P
--
A
L
V
L
A
P
N
K
I
L
A
A
Q
L
A
A
E
F
R
E
L
F
--
P
E
N
A
V
E
Y
F
I
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
G
K
D
L
Y
I
E
K
D
A
S
I
N
P
E
I
E
R
L
R
H
S
T
T
R
S
L
L
T
R
R
D
V
I
V
V
A
S
V
S
-
A
I
Y
G
L
G
D
P
R
E
Y
R
A
--------
R
N
L
V
V
--
R
E
V
L
L
E
R
L
L
E
L
G
Y
Q
R
N
D
I
D
L
S
P
G
R
F
R
A
K
G
E
V
-
L
E
I
F
P
A
Y
E
T
E
-
P
I
R
V
E
L
------------------------
G
F
V
L
F
P
A
T
H
Y
L
S
P
-
E
G
L
E
E
I
L
K
E
I
E
K
E
L
W
E
R
V
R
Y
F
E
E
R
G
E
V
L
Y
A
Q
R
L
K
E
R
T
L
Y
D
L
E
M
L
R
V
M
G
T
C
P
G
V
E
N
Y
A
R
Y
F
T
G
K
A
P
G
E
P
P
Y
T
L
L
D
Y
F
P
E
D
-
F
L
V
F
L
D
E
S
H
V
T
V
P
Q
L
Q
G
M
Y
R
G
D
Y
A
R
K
K
T
L
V
D
-
Y
G
F
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
L
E
R
--
V
S
Q
V
V
F
V
S
--
A
T
P
G
P
F
E
L
A
H
S
G
R
-
V
V
E
Q
I
I
R
P
T
G
L
L
D
P
L
V
R
V
-
K
P
T
E
N
Q
I
L
D
L
M
E
G
I
R
E
R
A
A
R
G
E
R
T
L
V
T
V
L
T
V
R
M
A
E
E
L
T
S
F
L
V
E
H
G
I
R
A
R
Y
L
--
H
H
E
-
L
D
A
F
K
R
Q
A
L
I
R
D
L
R
L
G
H
Y
D
C
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
A
R
G
E
V
W
L
Y
A
D
R
V
S
E
A
M
Q
R
A
I
E
E
T
N
R
R
R
-
A
L
Q
E
A
Y
N
L
E
H
G
I
T
P
E
T
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Fugue
67.54
69%
-80
- C4 -
1D9X
1
UVRB_BACCA
A:
[2-414]
------
E
G
R
F
Q
L
V
A
P
Y
E
P
Q
G
D
Q
P
Q
A
I
A
K
L
V
D
G
L
R
R
G
V
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
-------KP
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
L
K
E
F
F
--
P
H
N
A
V
E
Y
F
V
S
Y
----
Y
D
Y
Y
Q
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
-
C
I
Y
G
L
G
S
P
E
E
Y
R
E
L
-
V
V
S
L
R
V
G
M
E
I
E
--
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
--
F
R
G
T
F
R
V
R
G
D
V
-
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
A
---
E
V
D
A
L
T
G
K
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
A
L
R
P
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
-
F
L
I
I
V
D
E
S
H
V
T
L
P
Q
L
R
G
M
Y
N
G
D
R
A
R
K
Q
V
L
V
D
-
H
G
F
R
L
P
S
A
L
D
N
R
P
L
T
F
E
E
F
E
Q
K
--
I
N
Q
I
I
Y
V
S
--
A
T
P
G
P
Y
E
L
E
H
S
P
-
G
V
V
E
Q
I
I
R
P
T
G
L
L
D
P
T
I
D
V
-
R
P
T
K
G
Q
I
D
D
L
I
G
E
I
R
E
R
V
E
R
N
E
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
--
H
S
E
-
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
-------
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
-
N
A
N
G
H
V
I
M
Y
A
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
-
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Fugue
49.93
20%
-50
- C4 -
2EYQ
5
MFD_ECOLI
A:
[5-1150]
----
P
E
Q
Y
R
Y
T
L
P
V
K
---
A
G
E
Q
-----------------
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
----
P
--
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
---
T
D
Q
M
V
M
N
L
A
D
W
ETLP
Y
D
S
F
S
P
-----------------
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
-
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
--
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
-
L
D
L
F
P
M
G
S
-
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
-
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
-----------------
V
K
R
D
P
E
H
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
----
F
S
E
P
L
P
P
L
F
S
Y
F
P
A
N
T
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
P
M
-
R
P
L
L
P
P
Q
S
L
W
---
L
R
V
D
E
L
F
S
E
--
L
K
N
W
P
R
V
Q
--
L
K
T
E
--
H
L
P
T
K
A
A
-
N
A
N
L
G
F
Q
K
L
P
D
L
A
V
Q
A
Q
Q
-
K
A
P
L
D
A
L
R
K
F
L
-----
E
T
F
D
G
-
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
MR
L
D
E
-
A
S
D
R
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
------------
T
V
R
N
L
A
L
I
C
-------
E
S
D
L
L
G
E
R
V
A
R
R
R
Q
D
S
R
R
T
I
N
P
D
T
L
-
I
R
N
------
L
A
E
L
H
I
G
Q
P
V
V
H
L
E
H
G
V
G
R
-
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
-----------
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
ENAP
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
F
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
QP
L
A
M
D
R
L
V
C
G
D
VGFGKT
E
V
A
M
R
A
A
F
L
A
V
D
N
H
K
Q
V
A
V
L
V
PT
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
NWP
V
R
I
E
M
I
SRFRS
A
K
E
Q
T
Q
I
L
A
E
V
A
E
GKID
I
L
I
G
T
H
K
L
L
Q
S
DVKFKDLG
L
L
I
V
D
EEHRFG
V
R
H
K
E
R
I
K
A
M
R
AN
V
D
I
L
T
L
T
ATPIP
R
T
L
N
M
A
M
SGM
R
D
L
S
I
IATPPARR
L
A
V
K
T
F
V
R
E
YD
S
M
V
V
R
E
A
I
L
R
E
I
L
R
G
G
Q
V
Y
Y
L
Y
NDVEN
I
Q
K
A
A
E
R
L
A
E
L
V
PE
A
R
I
A
I
G
H
G
QMR
E
R
E
L
E
R
V
M
N
D
F
H
H
QRFN
V
L
V
C
TTIIETGIDIPTAN
T
I
I
I
ERADHFG
L
A
Q
L
H
Q
L
R
G
R
V
G
R
S
H
H
Q
A
Y
A
W
LLTPHPKAMT
T
D
A
Q
K
R
L
E
A
I
A
S
LEDLGA
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
IG
F
S
L
Y
M
E
L
L
E
N
A
V
D
A
L
K
A
GREPSLEDLTSQQ
T
E
V
E
LR
M
P
S
L
L
P
DDFIPD
V
N
T
R
L
S
F
Y
K
R
I
A
S
AKT
E
N
E
L
E
E
I
K
V
E
L
I
D
R
FGLLP
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
GIR
K
L
E
G
N
EK
G
G
V
I
E
F
A
EKNHVN
P
A
W
L
I
G
L
L
Q
KQPQH
Y
R
L
D
G
PT
R
L
K
F
I
Q
DLSE
R
K
T
R
I
E
W
V
R
Q
F
M
R
E
L
E
E
N
AI
56
HHSearch
46.48
19%
-54
- C4 -
3HJH
1
MFD_ECOLI
A:
[14-450]
------------------------------------
G
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
-
H
A
G
----
P
--
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
--
D
-
Q
M
V
M
-----------------
N
L
A
D
W
E
T
L
P
Y
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
-
A
L
V
M
K
K
G
Q
R
L
S
--
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
-
L
D
L
F
P
M
G
S
-
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
-
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
D
-----------------
P
E
H
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
F
S
E
P
----
L
P
P
L
F
S
Y
F
P
A
N
-
T
L
-
L
-
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
P
M
R
-
P
L
L
P
P
Q
S
L
W
L
R
V
D
E
L
F
S
E
L
K
N
W
P
R
V
Q
L
K
TE
H
L
P
T
K
A
-
A
N
------
A
N
L
G
F
Q
K
L
----
P
D
L
A
V
Q
A
Q
Q
K
A
P
L
D
A
L
R
K
F
L
E
T
F
---
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
--
M
R
L
-----------
D
E
A
S
D
R
G
--
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
T
V
R
N
L
A
L
-------
I
C
E
S
D
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Fugue
45.96
18%
-53
- C4 -
3HJH
1
MFD_ECOLI
A:
[5-450]
---------------------------
Y
R
Y
T
L
P
V
K
A
G
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
----
P
--
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
--
D
Q
M
-----
V
M
N
----
L
A
D
W
E
T
L
P
Y
-
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
-------
Q
R
G
V
L
I
V
P
V
N
T
-
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
-
A
L
V
M
K
K
G
Q
R
L
S
--
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
-
L
D
L
F
P
M
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
-
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
D
----------
P
E
H
I
Y
Q
Q
V
S
K
G
T
L
-------
P
A
G
I
E
Y
W
Q
P
L
F
----
F
S
E
P
L
P
P
L
F
S
Y
F
P
A
N
-
T
L
L
V
N
T
G
D
--
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
-
D
P
M
R
P
L
L
P
P
Q
S
L
W
L
R
V
D
E
L
F
S
E
--
L
K
N
W
P
R
V
Q
--
L
K
T
E
H
L
P
T
K
A
A
N
A
-
N
L
G
--
F
Q
K
L
P
D
L
A
V
Q
A
Q
Q
-
K
A
P
L
D
A
L
R
K
F
L
E
T
------
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
--
M
R
L
-
D
E
A
S
D
R
------------
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
T
V
R
N
L
A
L
-------
I
C
E
S
D
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Fugue
43.34
16%
-43
- C3 -
1WP9
1
?
A:
[1-486]
--------
M
V
L
R
R
D
L
I
Q
P
R
I
Y
Q
E
V
I
Y
A
K
C
K
E
------
T
N
C
L
I
V
L
P
T
G
L
G
K
T
L
I
A
M
M
I
A
E
Y
R
L
-
T
K
Y
G
G
K
--
V
L
M
L
A
P
T
K
P
L
V
L
Q
H
A
E
S
F
R
R
L
F
NL
P
P
E
K
I
V
A
L
T
G
E
----
K
S
P
E
E
R
S
K
A
W
A
R
A
K
V
I
V
A
T
P
Q
T
I
E
N
D
L
L
A
G
R
I
S
-----
L
E
D
V
S
L
I
V
F
D
E
A
H
-
R
A
V
G
N
Y
A
Y
V
F
I
A
R
E
-
Y
K
R
Q
A
K
N
P
L
V
I
G
L
T
A
S
P
G
S
T
P
E
K
I
M
E
V
I
N
N
L
G
I
E
H
I
E
Y
R
S
E
N
S
P
D
V
R
P
Y
V
K
G
I
R
F
E
W
V
R
V
D
L
P
E
I
Y
K
E
V
R
K
-
L
L
R
E
M
L
R
D
A
L
K
P
L
A
E
T
G
L
L
E
S
S
S
P
D
I
P
K
K
E
V
L
R
A
G
Q
I
I
N
E
E
M
A
K
G
---
N
H
D
L
R
G
L
L
L
Y
H
A
M
A
L
K
L
H
H
A
I
E
L
L
E
T
Q
G
L
S
A
L
R
A
Y
I
K
K
L
Y
E
E
A
K
A
G
---------------------------------------------------
S
T
K
A
S
K
E
I
F
S
D
K
R
M
K
K
A
--
I
S
L
L
V
Q
A
K
--
E
I
G
L
D
H
----------------------------
P
K
M
D
K
L
K
E
I
I
R
E
Q
-
L
Q
R
K
Q
N
S
K
I
I
V
F
T
N
Y
R
E
T
A
K
K
I
V
N
E
L
V
K
D
G
I
K
A
K
R
F
--
V
G
Q
A
S
K
Q
R
E
Q
K
L
I
L
D
E
F
A
R
G
E
F
N
V
L
V
A
T
S
V
G
E
E
G
L
D
V
P
E
V
D
L
V
V
-------
F
Y
E
P
-----
V
P
S
A
I
R
S
I
Q
R
R
G
R
T
G
R
-
H
M
P
G
R
V
I
I
L
M
A
K
G
T
R
D
E
A
Y
Y
W
S
S
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Fugue
43.10
65%
-54
- C4 -
1D9X
1
UVRB_BACCA
A:
[415-595]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
-
L
L
D
P
T
I
D
V
R
---
P
T
K
--------
G
Q
I
D
D
L
I
G
E
I
R
E
R
V
E
R
N
E
R
T
L
V
T
T
L
T
K
K
M
A
E
D
L
T
D
Y
L
K
E
A
G
I
K
V
A
Y
L
--
H
S
E
-
I
K
T
L
E
R
I
E
I
I
R
D
L
R
L
G
K
Y
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
DADKE-------
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
A
A
R
N
A
-
N
G
H
V
I
M
Y
A
-
D
T
I
T
K
S
M
E
I
A
I
Q
E
T
K
R
R
R
A
I
Q
E
E
Y
N
R
K
H
G
I
V
P
R
T
V
K
K
E
I
R
D
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------