@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1586: (2015-12-09 )
MKKIIYLGLACVSILTLSGCESIERSLKGDRYVDQKLAENSSKEATEQLNKKTKQALKADKKAFPQLDKAVAKNEAQVLIKTSKGDINIKLFPKYAPLAVENFLTHAKEGYYNGLSFHRVIKDFMIQSGDPNGDGTGGKSIWNSKDKKKDSGNGFVNEISPYLYNIRGSLAMANAGADTNGSQFFINQSQQDHSKQLSDKKVPKVIIKAYSEGGNPSLDGGYTVFGQVISGMETVDKIASVEVTKSDQPKEKITITSIKVIKDYKFK
Atome Classification :
(87 SA)
.........10........20........30........40........50........60........70......--------..80..-----.-.....90........100.--..-----------...----.-----------110-------.--------........120.......130..-...-...--140.......150.......160.-.-.-.-..-.170.-..-.---.----..180.......190--........200.......210.......220------.........230-........240.-.-.----.--...250.......260.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
K
I
I
Y
L
G
L
A
C
V
S
I
L
T
LS
G
C
E
S
I
E
R
S
LKGD
R
Y
V
D
Q
K
L
AENS
S
K
E
A
T
E
Q
L
N
K
K
T
K
Q
A
L
K
A
D
K
K
A
F
P
Q
L
D
K
A
V
AKNE
A
Q
--------
V
L
I
K
TS-----K-G
D
I
N
I
K
L
FPKYA
P
L
A
V
E
N
F
--
L
T
-----------
H
A
K
----E-----------G---------Y--------YNG
L
S
F
H
R
V
I
K
D
F
M
IQSGD-PNG-DGT-GGK--SIWNSKDKKKDSGNG
F
V
N
E
I
S
P
Y
L
-
Y
-N-I-RG-
S
L
A
M
A-NA-G---A----DTNG
S
Q
F
F
I
NQSQQ---
D
H
S
K
QLSDK
K
V
P
K
V
I
I
K
A
Y
SEGGNPSLDG--------
G
Y
T
V
F
G
Q
V
I
S
-
G
-
M
E
T
V
D
K
I
A
S
V
E
V-T-K----S--DQPK
E
K
I
T
I
T
S
I
K
V
IKDYKFK
117
HHSearch
86.09
42%
-69
- C6 -
2POE
4
?
A:
[15-177]
-------------------------------------------------------------------------
Y
F
Q
G
--------
V
R
I
I
T
N
-----
Y
-
G
D
L
K
F
E
L
F
C
S
Q
C
P
K
A
C
K
N
F
--
L
A
-----------
L
S
A
----
S
-----------
G
---------
Y
--------
Y
K
N
T
I
F
H
K
N
I
K
G
F
I
I
Q
G
G
D
-
P
T
G
-
T
G
K
-
G
G
E
--
S
I
Y
G
---------
R
Y
F
D
D
E
I
Y
P
E
L
-
K
-
Y
D
R
-
R
G
-
I
L
S
M
A
-
S
K
-
G
AKK
P
----
N
T
N
G
S
Q
F
F
I
T
Y
S
S
-----
L
----------------------
P
Q
L
N
G
--------
E
Y
V
I
F
G
K
L
I
D
-
G
-
F
E
T
L
N
T
L
E
N
C
P
S
-
D
-
K
----
S
--
H
K
P
I
D
E
I
I
I
K
D
I
V
I
H
S
N
P
---
122
HHSearch
85.87
46%
-80
- C6 -
2OK3
2
PPIL3_HUMAN
A:
[3-159]
-------------------------------------------------------------------------------------
V
T
L
H
T
D
-----
V
-
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
--
L
A
-----------
L
C
A
----
S
-----------
N
---------
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
-
P
T
G
-
T
G
R
-
G
G
N
--
S
I
W
G
---------
K
K
F
E
D
E
Y
S
E
Y
L
-
K
-
H
N
V
-
R
G
-
V
V
S
M
A
-
N
N
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
Y
G
K
-----
Q
----------------------
P
H
L
D
M
--------
K
Y
T
V
F
G
K
V
I
D
-
G
-
L
E
T
L
D
E
L
E
K
L
P
V
-
N
E
K
----
T
--
Y
R
P
L
N
D
V
H
I
K
D
I
T
I
H
A
N
P
F
A
-
21
PsiBlast_CBE
85.86
41%
-84
- C6 -
2A2N
1
C:
[12-175]
-------------------------------------------------------------------------
T
Q
A
E
GPKRVSDS
A
I
I
H
T
S
-----
M
-
G
D
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
--
C
V
-----------
H
S
R
----
N
-----------
G
---------
Y
--------
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
D
-
P
T
G
-
T
G
M
-
G
G
E
--
S
I
W
---------
G
G
E
F
E
D
E
F
H
S
T
L
-
R
-
H
-
D
-
R
P
Y
T
L
S
M
A
-
N
A
-
G
---
S
----
N
T
N
G
S
Q
F
F
I
T
V
----------------
V
P
-----------
T
P
W
L
D
N
--------
K
H
T
V
F
G
R
V
T
K
-
G
-
M
E
V
V
Q
R
I
S
N
V
K
V
-
N
P
K
----
T
--
D
K
P
Y
E
D
V
S
I
I
N
I
T
V
K
------
113
HHSearch
85.42
48%
-82
- C6 -
2FU0
-
?
A:
[5-159]
--------------------------------------------------------------------------
P
K
S
--------
A
I
I
Y
T
T
-----
M
-
G
D
I
H
I
S
L
F
Y
K
E
C
K
K
T
V
Q
N
F
--
S
V
-----------
H
S
I
----
N
-----------
G
---------
Y
--------
Y
N
N
C
I
F
H
R
V
I
K
H
F
M
V
Q
T
G
D
-
P
S
G
-
D
G
T
-
G
G
E
--
S
I
W
G
---------
N
E
F
E
D
E
F
F
D
H
L
-
N
-
H
-
S
K
P
F
-
M
V
S
M
A
-
N
C
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
T
V
P
-----
C
----------------------
P
W
L
D
F
--------
K
H
T
V
F
G
K
V
T
Q
-
G
-
S
K
I
V
L
D
I
E
K
V
R
T
-
D
-
K
----
R
--
D
K
P
L
E
D
I
K
I
L
N
I
K
I
N
------
119
HHSearch
85.17
49%
-75
- C6 -
2A2N
1
PPWD1_HUMAN
A:
[13-175]
-----------------------------------------------------------------
Q
A
E
G
P
-
K
R
V
S
D
S
--------
A
I
I
H
T
S
-----
M
-
G
D
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
--
C
V
-----------
H
S
R
----
N
-----------
G
---------
Y
--------
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
D
-
P
T
G
-
T
G
M
-
G
G
E
--
S
I
W
G
---------
G
E
F
E
D
E
F
H
S
T
L
-
R
-
H
-
D
R
P
Y
-
T
L
S
M
A
-
N
A
-
G
---
S
----
N
T
N
G
S
Q
F
F
I
T
V
V
P
-----
T
----------------------
P
W
L
D
N
--------
K
H
T
V
F
G
R
V
T
K
-
G
-
M
E
V
V
Q
R
I
S
N
V
K
V
-
N
P
K
----
T
--
D
K
P
Y
E
D
V
S
I
I
N
I
T
V
K
------
121
HHSearch
85.16
41%
-70
- C6 -
1ZKC
1
PPIL2_HUMAN
A:
[16-178]
-----------------------------------------------------------------------
P
R
G
S
G
Y
--------
V
R
L
H
T
N
-----
K
-
G
D
L
N
L
E
L
H
C
D
L
T
P
K
T
C
E
N
F
--
I
R
-----------
L
C
K
----
K
-----------
H
---------
Y
--------
Y
D
G
T
I
F
H
R
S
I
R
N
F
V
I
Q
G
G
D
-
P
T
G
-
T
G
T
-
G
G
E
--
S
Y
W
G
---------
K
P
F
K
D
E
F
R
P
N
L
-
S
-
H
-
T
G
R
G
-
I
L
S
M
A
-
N
S
-
G
---
P
----
N
S
N
R
S
Q
F
F
I
T
F
R
S
-----
C
----------------------
A
Y
L
D
K
--------
K
H
T
I
F
G
R
V
V
G
-
G
-
F
D
V
L
T
A
M
E
N
V
E
S
-
D
-
P
K---
T
--
D
R
P
K
E
E
I
R
I
D
A
T
T
V
F
V
D
P
Y
E
E
133
HHSearch
85.14
40%
-76
- C6 -
1IHG
-
PPID_BOVIN
A:
[12-186]
-----------------------------------------------------------------------
N
P
S
N
P
R
--------
V
F
F
D
V
D
IGGER
V
-
G
R
I
V
L
E
L
F
A
D
I
V
P
K
T
A
E
N
F
--
R
A
-----------
L
C
T
----
G
EKGIGPTTGKP
L
---------
H
--------
F
K
G
C
P
F
H
R
I
I
K
K
F
M
I
Q
G
G
D
-
F
S
N
Q
N
G
T
-
G
G
E
--
S
I
Y
G
---------
E
K
F
E
D
E
N
F
H
Y
K
-
H
-
D
-
K
-
E
G
-
L
L
S
M
A
-
N
A
-
G
---
S
----
N
T
N
G
S
Q
F
F
I
T
T
V
P
-----
T
----------------------
P
H
L
D
G
--------
K
H
V
V
F
G
Q
V
I
K
-
G
-
M
G
V
A
K
I
L
E
N
V
E
V
-
K
------
G
--
E
K
P
A
K
L
C
V
I
A
E
C
G
E
L
K
E
G
D
D
W
124
HHSearch
84.88
38%
-74
- C6 -
3BKP
4
?
A:
[18-196]
-----------------------------------------------------------------------
G
S
T
R
G
K
--------
V
V
L
H
T
S
-----
L
-
G
D
L
D
V
E
L
W
A
R
E
C
P
L
A
C
R
N
F
--
V
Q
-----------
L
C
L
----
E
-----------
G
---------
Y
--------
Y
V
N
T
I
F
H
R
V
V
K
D
F
I
V
Q
G
G
D
-
P
T
G
-
T
G
R
-
G
G
A
DT
T
F
D
G
---------
K
P
F
D
V
E
T
H
P
R
L
-
K
-
F
-
R
Y
R
G
-
L
V
G
V
A
-
N
L
-
G
---------
T
N
G
N
Q
F
F
I
T
L
A
R
-----
A
----------------------
D
V
L
N
N
--------
A
Y
T
L
F
G
K
V
T
G
H
T
-
L
Y
N
L
M
K
F
N
D
L
E
V
-
G
-
K
----
E
--
D
R
P
M
T
P
P
F
I
K
S
V
D
V
L
W
N
P
F
E
D
1
PsiBlast_PDB
84.43
41%
-85
- C6 -
2A2N
1
PPWD1_HUMAN
A:
[13-175]
--------------------------------------------------------------------------
Q
A
E
G
P
K
RVSD
S
A
I
I
H
T
S
-----
M
-
G
D
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
--
C
V
-----------
H
S
R
----
N
-----------
G
---------
Y
--------
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
D
-
P
T
G
-
T
G
M
-
G
G
E
--
S
I
W
---------
G
G
E
F
E
D
E
F
H
S
T
L
-
R
-
H
-
D
-
R
P
Y
T
L
S
M
A
-
N
A
-
G
---
S
----
N
T
N
G
S
Q
F
F
I
T
V
----------------
V
P
-----------
T
P
W
L
D
N
--------
K
H
T
V
F
G
R
V
T
K
-
G
-
M
E
V
V
Q
R
I
S
N
V
K
V
-
N
P
K
----
T
--
D
K
P
Y
E
D
V
S
I
I
N
I
T
V
K
------
29
PsiBlast_CBE
83.99
36%
-75
- C6 -
1ZKC
1
B:
[15-176]
----------------------------------------------------------------------
V
P
R
G
S
G
Y
--------
V
R
L
H
T
N
-----
K
-
G
D
L
N
L
E
L
H
C
D
L
T
P
K
T
C
E
N
F
--
I
R
-----------
L
C
K
----
K
-----------
H
---------
Y
--------
Y
D
G
T
I
F
H
R
S
I
R
N
F
V
I
Q
G
G
D
-
P
T
G
-
T
G
T
-
G
G
E
--
S
Y
W
---------
G
K
P
F
K
D
E
F
R
P
N
L
-
S
-
H
-
T
G
R
G
-
I
L
S
M
A
-
N
S
-
G
---
P
----
N
S
N
R
S
Q
F
F
I
T
F
R
S
C
--------------------
A
Y
-------
L
D
K
--------
K
H
T
I
F
G
R
V
V
G
-
G
-
F
D
V
L
T
A
M
E
N
V
E
S
D
P
-
K
----
T
--
D
R
P
K
E
E
I
R
I
D
A
T
T
V
F
V
D
P
Y
E
E
30
PsiBlast_CBE
82.82
36%
-73
- C6 -
1ZKC
1
PPIL2_HUMAN
A:
[15-176]
----------------------------------------------------------------------
V
P
R
G
S
G
Y
--------
V
R
L
H
T
N
-----
K
-
G
D
L
N
L
E
L
H
C
D
L
T
P
K
T
C
E
N
F
--
I
R
-----------
L
C
K
----
K
-----------
H
---------
Y
--------
Y
D
G
T
I
F
H
R
S
I
R
N
F
V
I
Q
G
G
D
-
P
T
G
-
T
G
T
-
G
G
E
--
S
Y
W
---------
G
K
P
F
K
D
E
F
R
P
N
L
-
S
-
H
-
T
G
R
G
-
I
L
S
M
A
-
N
S
-
G
---
P
----
N
S
N
R
S
Q
F
F
I
T
F
R
S
C
--------------------
A
Y
-------
L
D
K
--------
K
H
T
I
F
G
R
V
V
G
-
G
-
F
D
V
L
T
A
M
E
N
V
E
S
D
P
-
K
----
T
--
D
R
P
K
E
E
I
R
I
D
A
T
T
V
F
V
D
P
Y
E
E
120
HHSearch
82.27
38%
-77
- C6 -
2HQ6
2
CWC27_HUMAN
A:
[21-183]
-----------------------------------------------------------------------
P
P
T
N
G
K
--------
V
L
L
K
T
T
-----
A
-
G
D
I
D
I
E
L
W
S
K
E
A
P
K
A
C
R
N
F
--
I
Q
-----------
L
C
L
----
E
-----------
A
---------
Y
--------
Y
D
N
T
I
F
H
R
V
V
P
G
F
I
V
Q
G
G
D
-
P
T
G
-
T
G
S
-
G
G
E
--
S
I
Y
G
---------
A
P
F
K
D
E
F
H
S
R
L
-
R
F
N
-
R
-
R
G
-
L
V
A
M
A
-
N
A
-
G
---
S
----
H
D
N
G
S
Q
F
F
F
T
L
G
R
-----
A
----------------------
D
E
L
N
N
--------
K
H
T
I
F
G
K
V
T
G
-
D
T
V
Y
N
M
L
R
L
S
E
V
D
I
-
D
-
D
----
D
--
E
R
P
H
N
P
H
K
I
K
S
C
E
V
L
F
N
P
F
D
-
8
PsiBlast_PDB
82.04
37%
-75
- C6 -
2POE
4
?
A:
[19-173]
-------------------------------------------------------------------------------------
V
R
I
I
T
N
-----
Y
-
G
D
L
K
F
E
L
F
C
S
Q
C
P
K
A
C
K
N
F
--
L
A
-----------
L
S
A
----
S
-----------
G
---------
Y
--------
Y
K
N
T
I
F
H
K
N
I
K
G
F
I
I
Q
G
G
D
-
P
T
G
-
T
G
K
-
G
G
E
--
S
I
Y
---------
G
R
Y
F
D
D
E
I
Y
P
E
L
K
Y
-
D
-
R
-
R
G
-
I
L
S
M
A
-
S
K
-
G
---
A
KKP-
N
T
N
G
S
Q
F
F
I
T
Y
S
S
L
---------------------------
P
Q
L
N
G
--------
E
Y
V
I
F
G
K
L
I
D
-
G
-
F
E
T
L
N
T
L
E
N
C
P
S
-
D
-
K
----
S
--
H
K
P
I
D
E
I
I
I
K
D
I
V
I
H
S
N
P
---
38
PsiBlast_CBE
81.94
32%
-74
- C6 -
3BKP
4
?
A:
[21-192]
--------------------------------------------------------------------------
R
G
K
--------
V
V
L
H
T
S
-----
L
-
G
D
L
D
V
E
L
W
A
R
E
C
P
L
A
C
R
N
F
--
V
Q
-----------
L
C
L
----
E
-----------
G
---------
Y
--------
Y
V
N
T
I
F
H
R
V
V
K
D
F
I
V
Q
G
G
D
-
P
T
G
-
T
G
R
-
G
G
--------
A
D
T
T
F
D
-
G
K
P
F
D
V
E
T
H
P
R
L
K
F
-
R
-
Y
-
R
G
-
L
V
G
V
A
-
N
L
-
G
---------
T
N
G
N
Q
F
F
I
T
L
A
R
A
---
D
------------------------
V
L
N
N
--------
A
Y
T
L
F
G
K
V
T
G
H
T
-
L
Y
N
L
M
K
F
N
D
L
E
V
-
G
-
K
----
E
--
D
R
P
M
T
P
P
F
I
K
S
V
D
V
L
W
N
P
F
E
D
3
PsiBlast_PDB
81.78
40%
-75
- C6 -
2OK3
2
PPIL3_HUMAN
A:
[3-154]
-------------------------------------------------------------------------------------
V
T
L
H
T
D
-----
V
-
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
--
L
A
-----------
L
C
A
----
S
-----------
N
---------
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
-
P
T
G
-
T
G
R
-
G
G
N
--
S
I
W
G
K
K
---------
F
E
D
E
Y
S
E
Y
L
K
H
-
N
-
V
-
R
G
-
V
V
S
M
A
-
N
N
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
Y
G
K
Q
---------------------------
P
H
L
D
M
--------
K
Y
T
V
F
G
K
V
I
D
-
G
-
L
E
T
L
D
E
L
E
K
L
P
V
-
N
E
K
----
T
--
Y
R
P
L
N
D
V
H
I
K
D
I
T
I
H
A
N
P
F
A
-
4
PsiBlast_PDB
81.55
40%
-77
- C6 -
2OJU
1
PPIL3_HUMAN
A:
[9-160]
-------------------------------------------------------------------------------------
V
T
L
H
T
D
-----
V
-
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
--
L
A
-----------
L
C
A
----
S
-----------
N
---------
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
-
P
T
G
-
T
G
R
-
G
G
N
--
S
I
W
G
K
K
---------
F
E
D
E
Y
S
E
Y
L
K
H
-
N
-
V
-
R
G
-
V
V
S
M
A
-
N
N
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
Y
G
K
Q
---------------------------
P
H
L
D
M
--------
K
Y
T
V
F
G
K
V
I
D
-
G
-
L
E
T
L
D
E
L
E
K
L
P
V
-
N
E
K
----
T
--
Y
R
P
L
N
D
V
H
I
K
D
I
T
I
H
A
N
P
F
--
22
PsiBlast_CBE
81.47
40%
-81
- C6 -
2OJU
1
PPIL3_HUMAN
B:
[9-160]
-------------------------------------------------------------------------------------
V
T
L
H
T
D
-----
V
-
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
--
L
A
-----------
L
C
A
----
S
-----------
N
---------
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
-
P
T
G
-
T
G
R
-
G
G
N
--
S
I
W
G
K
K
---------
F
E
D
E
Y
S
E
Y
L
K
H
-
N
-
V
-
R
G
-
V
V
S
M
A
-
N
N
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
Y
G
K
Q
---------------------------
P
H
L
D
M
--------
K
Y
T
V
F
G
K
V
I
D
-
G
-
L
E
T
L
D
E
L
E
K
L
P
V
-
N
E
K
----
T
--
Y
R
P
L
N
D
V
H
I
K
D
I
T
I
H
A
N
P
F
A
-
2
PsiBlast_PDB
81.40
40%
-73
- C6 -
1XYH
-
PPIL3_HUMAN
A:
[3-154]
-------------------------------------------------------------------------------------
V
T
L
H
T
D
-----
V
-
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
--
L
A
-----------
L
C
A
----
S
-----------
N
---------
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
-
P
T
G
-
T
G
R
-
G
G
N
--
S
I
W
G
K
K
---------
F
E
D
E
Y
S
E
Y
L
K
H
-
N
-
V
-
R
G
-
V
V
S
M
A
-
N
N
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
Y
G
K
Q
---------------------------
P
H
L
D
M
--------
K
Y
T
V
F
G
K
V
I
D
-
G
-
L
E
T
L
D
E
L
E
K
L
P
V
-
N
E
K
----
T
--
Y
R
P
L
N
D
V
H
I
K
D
I
T
I
H
A
N
P
F
A
-
116
HHSearch
81.23
37%
-71
- C6 -
2B71
5
?
A:
[33-191]
---------------------------------------------------------------------
K
G
H
T
E
R
G
Y
--------
I
T
I
Y
T
N
-----
L
-
G
D
F
E
V
E
L
Y
W
Y
H
S
P
K
T
C
L
N
F
--
Y
T
-----------
L
C
E
----
M
-----------
G
---------
F
--------
Y
D
N
T
I
F
H
R
V
I
P
N
F
V
I
Q
G
G
D
-
P
T
G
-
T
G
K
-
G
G
K
--
S
I
Y
G
---------
E
Y
F
E
D
E
I
N
K
E
L
-
K
-
H
-
T
G
A
G
-
I
L
S
M
S
-
N
N
-
G
---
P
----
N
T
N
S
S
Q
F
F
I
T
L
A
P
-----
L
----------------------
P
H
L
D
G
--------
K
H
T
I
F
A
R
V
S
K
-
N
-
M
T
C
I
E
N
I
A
S
V
Q
T
-
T
-
A
----
T
--
N
K
P
I
F
D
L
K
I
L
R
T
S
T
-------
12
PsiBlast_PDB
80.71
33%
-87
- C6 -
4R3E
3
CWC27_HUMAN
A:
[15-169]
---------------------------------------------------------------------------
G
K
--------
V
L
L
K
T
T
-----
A
-
G
D
I
D
I
E
L
W
S
K
E
A
P
K
A
C
R
N
F
--
I
Q
-----------
L
C
L
----
E
-----------
A
---------
Y
--------
Y
D
N
T
I
F
H
R
V
V
P
G
F
I
V
Q
G
G
D
-
P
T
G
-
T
G
S
-
G
G
E
--
S
I
Y
---------
G
A
P
F
K
D
E
F
H
S
R
L
R
F
-
N
-
R
-
R
G
-
L
V
A
M
A
-
N
A
-
G
---
S
----
H
D
N
G
S
Q
F
F
F
T
L
G
R
A
---
D
------------------------
E
L
N
N
--------
K
H
T
I
F
G
K
V
T
G
-
D
T
V
Y
N
M
L
R
L
S
E
V
D
I
-
D
-
D
----
D
--
E
R
P
H
N
P
H
K
I
K
S
C
E
V
L
F
N
P
F
D
D
11
PsiBlast_PDB
80.49
34%
-86
- C6 -
2HQ6
2
CWC27_HUMAN
A:
[25-179]
---------------------------------------------------------------------------
G
K
--------
V
L
L
K
T
T
-----
A
-
G
D
I
D
I
E
L
W
S
K
E
A
P
K
A
C
R
N
F
--
I
Q
-----------
L
C
L
----
E
-----------
A
---------
Y
--------
Y
D
N
T
I
F
H
R
V
V
P
G
F
I
V
Q
G
G
D
-
P
T
G
-
T
G
S
-
G
G
E
--
S
I
Y
---------
G
A
P
F
K
D
E
F
H
S
R
L
R
F
-
N
-
R
-
R
G
-
L
V
A
M
A
-
N
A
-
G
---
S
----
H
D
N
G
S
Q
F
F
F
T
L
G
R
A
---
D
---
E
L
N
N
K
-----------------------------
H
T
I
F
G
K
V
T
G
-
D
T
V
Y
N
M
L
R
L
S
E
V
D
I
-
D
-
D
----
D
--
E
R
P
H
N
P
H
K
I
K
S
C
E
V
L
F
N
P
F
D
-
9
PsiBlast_PDB
79.76
37%
-77
- C6 -
2QER
5
?
A:
[19-173]
-------------------------------------------------------------------------------------
V
R
I
I
T
N
-----
Y
-
G
D
L
K
F
E
L
F
C
S
Q
C
P
K
A
C
K
N
F
--
L
A
-----------
L
S
A
----
S
-----------
G
---------
Y
--------
Y
K
N
T
I
F
H
K
N
I
K
G
F
I
I
Q
G
G
D
-
P
T
G
-
T
G
K
-
G
G
E
--
S
I
Y
---------
G
R
Y
F
D
D
E
I
Y
P
E
L
K
Y
-
D
-
R
-
R
G
-
I
L
S
M
A
-
S
------
A
SKKP
N
T
N
G
S
Q
F
F
I
T
Y
S
S
L
---------------------------
P
Q
L
N
G
--------
E
Y
V
I
F
G
K
L
I
D
-
G
-
F
E
T
L
N
T
L
E
N
C
P
S
-
D
-
K
----
S
--
H
K
P
I
D
E
I
I
I
K
D
I
V
I
H
S
N
----
123
HHSearch
76.68
31%
-61
- C6 -
3BO7
13
?
A:
[5-176]
-------------------------------------------------------------------------
K
K
G
Y
--------
L
R
I
V
T
T
-----
Q
-
G
S
L
N
I
E
L
H
A
D
M
A
P
R
A
C
D
S
F
--
L
R
-----------
L
C
A
----
V
-----------
K
---------
Y
--------
F
D
D
T
I
F
H
R
C
I
R
N
F
M
I
Q
G
G
R
-
A
E
L
-
R
Q
P
Q
S
P
R
--
S
I
S
G
F
-----
P
G
G
A
P
F
E
D
E
F
D
N
R
L
-
V
-
H
-
Q
G
I
G
-
V
L
S
M
A
-
N
D
-
G
---
K
----
H
S
N
L
S
E
F
F
I
T
F
K
S
-----
C
----------------------
E
H
L
N
N
--------
K
H
T
I
F
G
R
V
V
G
-
G
-
L
D
V
L
R
Q
W
E
K
L
E
T
-
D
-
K
----
K
--
D
K
P
L
K
P
P
K
V
E
E
I
I
V
F
K
N
P
F
--
82
PsiBlast_CBE
76.32
38%
-70
- C6 -
2RMC
1
PPIC_MOUSE
C:
[22-165]
--------------------------------------------------------------------------------------------------
G
R
I
V
I
G
L
F
G
N
V
V
P
K
T
V
E
N
F
VA
L
A
-----------
T
G
E
----
K
-----------
G
---------
Y
G-------
Y
K
G
S
I
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
T
A
R
D
G
T
-
G
G
M
--
S
I
Y
---------
G
E
T
F
P
D
E
N
F
K
L
K
-
H
-
Y
-
G
-
I
G
-
W
V
S
M
A
-
N
A
-
G
---
P
----
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
---
T
W
------------------------
L
D
G
--------
K
H
V
V
F
G
K
V
L
D
-
G
-
M
T
V
V
H
S
I
E
L
Q
A
T
-
D
-
G
----
H
--
D
R
P
L
T
D
C
T
I
V
N
S
G
K
I
D
V
K
T
P
F
23
PsiBlast_CBE
75.26
37%
-57
- C6 -
3EOV
1
?
B:
[9-168]
--------------------------------------------------------------------
E
V
T
A
K
V
Y
F
D
--------
V
M
I
D
S
E
-----
P
L
G
R
I
T
I
G
L
F
G
K
D
A
P
L
T
T
E
N
F
RQ
L
C
-----------
T
G
E
----
H
-----------
G
---------
F
G-------
Y
K
D
S
I
F
H
R
V
I
Q
N
F
M
I
Q
G
G
D
F
T
N
F
-
D
G
T
-
G
G
K
--
S
I
Y
G
E
K
---------
F
A
D
E
-
N
L
N
V
-
K
-
H
-
F
-
V
G
-
A
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
T
A
P
---------------------------
T
P
W
L
D
G
--------
R
H
V
V
F
G
K
V
L
D
-
G
-
M
D
V
V
L
R
I
E
K
T
K
T
-
N
-
S
----
H
--
D
R
P
V
K
P
V
K
I
V
A
S
G
E
L
------
39
PsiBlast_CBE
74.91
40%
-73
- C6 -
2ESL
7
PPIC_HUMAN
F:
[30-171]
--------------------------------------------------------------------------------------------------
G
R
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
VA
L
A
-----------
T
G
E
----
K
-----------
G
---------
Y
G-------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
I
T
T
G
-
D
G
T
-
G
G
V
--
S
I
Y
---------
G
E
T
F
P
D
E
N
F
K
L
K
-
H
-
Y
-
G
-
I
G
-
W
V
S
M
A
-
N
A
-
G
---
P
----
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
---
T
W
------------------------
L
D
G
--------
K
H
V
V
F
G
K
V
I
D
-
G
-
M
T
V
V
H
S
I
E
L
Q
A
T
-
D
-
G
----
H
--
D
R
P
L
T
N
C
S
I
I
N
S
G
K
I
D
V
K
T
P
F
79
PsiBlast_CBE
74.85
33%
-72
- C6 -
2WFJ
3
PPIG_HUMAN
A:
[24-176]
--------------------------------------------------------------------------------------------------
G
R
V
V
F
E
L
F
S
D
V
C
P
K
T
C
E
N
F
R
C
L
C
-----------
T
G
E
----
K
-----------
G
TGKSTQKPL
H
--------
Y
K
S
C
L
F
H
R
V
V
K
D
F
M
V
Q
G
G
D
F
S
E
G
-
N
G
R
-
G
G
E
--
S
I
Y
---------
G
G
F
F
E
D
E
S
F
A
V
K
-
H
-
N
-
K
-
E
F
-
L
L
S
M
A
-
N
R
-
G
---
K
----
D
T
N
G
S
Q
F
F
I
T
T
K
P
---------------------------
T
P
H
L
D
G
--------
H
H
V
V
F
G
Q
V
I
S
-
G
-
Q
E
V
V
R
E
I
E
N
Q
K
T
-
D
-
A
----
A
--
S
K
P
F
A
E
V
R
I
L
S
C
G
E
L
------
42
PsiBlast_CBE
74.80
40%
-73
- C6 -
2ESL
6
PPIC_HUMAN
C:
[30-171]
--------------------------------------------------------------------------------------------------
G
R
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
VA
L
A
-----------
T
G
E
----
K
-----------
G
---------
Y
G-------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
I
T
T
G
-
D
G
T
-
G
G
V
--
S
I
Y
---------
G
E
T
F
P
D
E
N
F
K
L
K
-
H
-
Y
-
G
-
I
G
-
W
V
S
M
A
-
N
A
-
G
---
P
----
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
---
T
W
------------------------
L
D
G
--------
K
H
V
V
F
G
K
V
I
D
-
G
-
M
T
V
V
H
S
I
E
L
Q
A
T
-
D
-
G
----
H
--
D
R
P
L
T
N
C
S
I
I
N
S
G
K
I
D
V
K
T
P
F
40
PsiBlast_CBE
74.68
40%
-73
- C6 -
2ESL
6
PPIC_HUMAN
E:
[30-171]
--------------------------------------------------------------------------------------------------
G
R
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
VA
L
A
-----------
T
G
E
----
K
-----------
G
---------
Y
G-------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
I
T
T
G
-
D
G
T
-
G
G
V
--
S
I
Y
---------
G
E
T
F
P
D
E
N
F
K
L
K
-
H
-
Y
-
G
-
I
G
-
W
V
S
M
A
-
N
A
-
G
---
P
----
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
---
T
W
------------------------
L
D
G
--------
K
H
V
V
F
G
K
V
I
D
-
G
-
M
T
V
V
H
S
I
E
L
Q
A
T
-
D
-
G
----
H
--
D
R
P
L
T
N
C
S
I
I
N
S
G
K
I
D
V
K
T
P
F
83
PsiBlast_CBE
74.58
38%
-68
- C6 -
2RMC
1
PPIC_MOUSE
A:
[22-165]
--------------------------------------------------------------------------------------------------
G
R
I
V
I
G
L
F
G
N
V
V
P
K
T
V
E
N
F
V
A
L
A
-----------
T
G
E
----
K
-----------
G
---------
Y
G-------
Y
K
G
S
I
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
T
A
R
D
G
T
-
G
G
M
--
S
I
Y
---------
G
E
T
F
P
D
E
N
F
K
L
K
-
H
-
Y
-
G
-
I
G
-
W
V
S
M
A
-
N
A
-
G
---
P
----
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
---
T
W
------------------------
L
D
G
--------
K
H
V
V
F
G
K
V
L
D
-
G
-
M
T
V
V
H
S
I
E
L
Q
A
T
-
D
-
G
----
H
--
D
R
P
L
T
D
C
T
I
V
N
S
G
K
I
D
V
K
T
P
F
10
PsiBlast_PDB
74.21
40%
-66
- C6 -
1H0P
1
CYP5_CAEEL
A:
[21-164]
--------------------------------------------------------------------------------------------------
G
R
I
V
I
G
L
F
G
K
T
V
P
K
T
A
T
N
F
--
I
E
-----------
L
A
K
KPKG
E
-----------
G
---------
Y
---------
P
G
S
K
F
H
R
V
I
A
D
F
M
I
Q
G
G
D
F
T
R
G
-
D
G
T
-
G
G
R
--
S
I
Y
G
E
K
---------
F
A
D
E
N
F
K
L
K
-
H
-
Y
-
G
-
A
G
-
W
L
S
M
A
-
N
A
-
G
---
A
----
D
T
N
G
S
Q
F
F
I
T
T
V
K
---------------------------
T
P
W
L
D
G
--------
R
H
V
V
F
G
K
I
L
E
-
G
-
M
D
V
V
R
K
I
E
Q
T
E
K
-
L
-
P
----
G
--
D
R
P
K
Q
D
V
I
I
A
A
S
G
H
I
A
V
D
T
P
F
41
PsiBlast_CBE
74.05
40%
-71
- C6 -
2ESL
6
PPIC_HUMAN
D:
[30-171]
--------------------------------------------------------------------------------------------------
G
R
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
VA
L
A
-----------
T
G
E
----
K
-----------
G
---------
Y
G-------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
I
T
T
G
-
D
G
T
-
G
G
V
--
S
I
Y
---------
G
E
T
F
P
D
E
N
F
K
L
K
-
H
-
Y
-
G
-
I
G
-
W
V
S
M
A
-
N
A
-
G
---
P
----
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
---
T
W
------------------------
L
D
G
--------
K
H
V
V
F
G
K
V
I
D
-
G
-
M
T
V
V
H
S
I
E
L
Q
A
T
-
D
-
G
----
H
--
D
R
P
L
T
N
C
S
I
I
N
S
G
K
I
D
V
K
T
P
F
43
PsiBlast_CBE
74.03
40%
-72
- C6 -
2ESL
6
PPIC_HUMAN
B:
[30-171]
--------------------------------------------------------------------------------------------------
G
R
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
VA
L
A
-----------
T
G
E
----
K
-----------
G
---------
Y
G-------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
I
T
T
G
-
D
G
T
-
G
G
V
--
S
I
Y
---------
G
E
T
F
P
D
E
N
F
K
L
K
-
H
-
Y
-
G
-
I
G
-
W
V
S
M
A
-
N
A
-
G
---
P
----
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
---
T
W
------------------------
L
D
G
--------
K
H
V
V
F
G
K
V
I
D
-
G
-
M
T
V
V
H
S
I
E
L
Q
A
T
-
D
-
G
----
H
--
D
R
P
L
T
N
C
S
I
I
N
S
G
K
I
D
V
K
T
P
F
44
PsiBlast_CBE
73.95
40%
-71
- C6 -
2ESL
6
PPIC_HUMAN
A:
[30-171]
--------------------------------------------------------------------------------------------------
G
R
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
V
A
L
A
-----------
T
G
E
----
K
-----------
G
---------
Y
G-------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
I
T
T
G
-
D
G
T
-
G
G
V
--
S
I
Y
---------
G
E
T
F
P
D
E
N
F
K
L
K
-
H
-
Y
-
G
-
I
G
-
W
V
S
M
A
-
N
A
-
G
---
P
----
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
---
T
W
------------------------
L
D
G
--------
K
H
V
V
F
G
K
V
I
D
-
G
-
M
T
V
V
H
S
I
E
L
Q
A
T
-
D
-
G
----
H
--
D
R
P
L
T
N
C
S
I
I
N
S
G
K
I
D
V
K
T
P
F
81
PsiBlast_CBE
73.25
38%
-70
- C6 -
2RMC
1
PPIC_MOUSE
E:
[22-165]
--------------------------------------------------------------------------------------------------
G
R
I
V
I
G
L
F
G
N
V
V
P
K
T
V
E
N
F
VA
L
A
-----------
T
G
E
----
K
-----------
G
---------
Y
G-------
Y
K
G
S
I
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
T
A
R
D
G
T
-
G
G
M
--
S
I
Y
---------
G
E
T
F
P
D
E
N
F
K
L
K
-
H
-
Y
-
G
-
I
G
-
W
V
S
M
A
-
N
A
-
G
---
P
----
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
---
T
W
------------------------
L
D
G
--------
K
H
V
V
F
G
K
V
L
D
-
G
-
M
T
V
V
H
S
I
E
L
Q
A
T
-
D
-
G
----
H
--
D
R
P
L
T
D
C
T
I
V
N
S
G
K
I
D
V
K
T
P
F
80
PsiBlast_CBE
73.22
38%
-68
- C6 -
2RMC
1
PPIC_MOUSE
G:
[22-165]
--------------------------------------------------------------------------------------------------
G
R
I
V
I
G
L
F
G
N
V
V
P
K
T
V
E
N
F
VA
L
A
-----------
T
G
E
----
K
-----------
G
---------
Y
G-------
Y
K
G
S
I
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
T
A
R
D
G
T
-
G
G
M
--
S
I
Y
---------
G
E
T
F
P
D
E
N
F
K
L
K
-
H
-
Y
-
G
-
I
G
-
W
V
S
M
A
-
N
A
-
G
---
P
----
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
---
T
W
------------------------
L
D
G
--------
K
H
V
V
F
G
K
V
L
D
-
G
-
M
T
V
V
H
S
I
E
L
Q
A
T
-
D
-
G
----
H
--
D
R
P
L
T
D
C
T
I
V
N
S
G
K
I
D
V
K
T
P
F
16
PsiBlast_PDB
73.19
37%
-57
- C6 -
3EOV
1
?
A:
[9-168]
--------------------------------------------------------------------
E
V
T
A
K
V
Y
F
D
--------
V
M
I
D
S
E
-----
P
L
G
R
I
T
I
G
L
F
G
K
D
A
P
L
T
T
E
N
F
R
Q
L
C
-----------
T
G
E
----
H
-----------
G
---------
F
G-------
Y
K
D
S
I
F
H
R
V
I
Q
N
F
M
I
Q
G
G
D
F
T
N
F
-
D
G
T
-
G
G
K
--
S
I
Y
G
E
K
---------
F
A
D
E
-
N
L
N
V
-
K
-
H
-
F
-
V
G
-
A
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
T
A
P
---------------------------
T
P
W
L
D
G
--------
R
H
V
V
F
G
K
V
L
D
-
G
-
M
D
V
V
L
R
I
E
K
T
K
T
-
N
-
S
----
H
--
D
R
P
V
K
P
V
K
I
V
A
S
G
E
L
------
35
PsiBlast_CBE
72.94
36%
-56
- C6 -
2POY
2
?
C:
[30-186]
----------------------------------------------------------------------------------------
Q
T
P
-----
A
-
G
R
I
T
M
E
L
F
A
D
K
V
P
I
T
A
E
N
F
RA
L
C
-----------
T
G
E
----
K
-----------
G
---------
M
GQSGKPLC
Y
T
G
S
F
F
H
R
I
I
P
Q
F
M
I
Q
G
G
D
F
T
R
G
-
D
G
T
-
G
G
E
--
S
I
Y
G
-
K
F
R
D
E
---
N
F
V
Y
T
H
D
A
P
F
L
-----------
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
----------------
T
V
P
-----------
C
P
W
L
D
G
--------
K
H
V
V
F
G
K
V
L
E
-
G
-
M
E
V
V
K
S
I
E
K
C
G
--
S
-
Q
----
N
--
G
K
P
T
K
S
V
C
I
T
A
S
G
V
-------
37
PsiBlast_CBE
72.50
36%
-55
- C6 -
2POY
1
?
A:
[30-186]
----------------------------------------------------------------------------------------
Q
T
P
-----
A
-
G
R
I
T
M
E
L
F
A
D
K
V
P
I
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
M
GQSGKPLC
Y
T
G
S
F
F
H
R
I
I
P
Q
F
M
I
Q
G
G
D
F
T
R
G
-
D
G
T
-
G
G
E
--
S
I
Y
G
-
K
F
R
D
E
---
N
F
V
Y
T
H
D
A
P
F
L
-----------
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
----------------
T
V
P
-----------
C
P
W
L
D
G
--------
K
H
V
V
F
G
K
V
L
E
-
G
-
M
E
V
V
K
S
I
E
K
C
G
--
S
-
Q
----
N
--
G
K
P
T
K
S
V
C
I
T
A
S
G
V
-------
36
PsiBlast_CBE
72.34
36%
-51
- C6 -
2POY
2
?
B:
[30-186]
----------------------------------------------------------------------------------------
Q
T
P
-----
A
-
G
R
I
T
M
E
L
F
A
D
K
V
P
I
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
M
GQSGKPLC
Y
T
G
S
F
F
H
R
I
I
P
Q
F
M
I
Q
G
G
D
F
T
R
G
-
D
G
T
-
G
G
E
--
S
I
Y
G
-
K
F
R
D
E
---
N
F
V
Y
T
H
D
A
P
F
L
-----------
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
----------------
T
V
P
-----------
C
P
W
L
D
G
--------
K
H
V
V
F
G
K
V
L
E
-
G
-
M
E
V
V
K
S
I
E
K
C
G
--
S
-
Q
----
N
--
G
K
P
T
K
S
V
C
I
T
A
S
G
V
-------
98
PsiBlast_CBE
71.84
32%
-67
- C6 -
1C5F
2
CYP1_BRUMA
M:
[21-170]
--------------------------------------------------------------------------------------------------
G
R
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
--
L
M
LCTGMAGTGKI
S
G
K
----
P
-----------
L
---------
H
--------
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
F
T
K
G
-
D
G
T
-
G
G
E
--
S
I
Y
G
G
---
M
F
D
D
E
E
F
V
M
K
H
D
E
P
F
V
-----------
V
S
M
A
-
N
K
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
T
T
P
A
---------------------------
P
H
L
N
N
--------
I
H
V
V
F
G
K
V
V
S
-
G
-
Q
E
V
V
T
K
I
E
Y
L
K
T
-
N
-
S
----
K
--
N
R
P
L
A
D
V
V
I
L
N
C
G
E
L
V
-----
126
HHSearch
71.78
37%
-69
- C6 -
3S6M
3
?
A:
[3-167]
--------------------------------------------------------------------------
G
S
M
--------
V
E
L
H
T
N
-----
H
-
G
V
I
K
L
E
L
D
E
A
K
A
P
K
T
V
E
N
F
--
L
N
-----------
Y
V
K
----
K
-----------
G
---------
H
--------
Y
D
G
T
I
F
H
R
V
I
N
G
F
M
I
Q
G
G
G
-
F
E
P
-
G
L
K
--
Q
K
--
P
T
-
D
---------
A
P
I
A
N
E
A
N
N
G
L
-
K
-
N
-
D
-
T
Y
-
T
I
A
M
A
-
R
T
N
D
---
P
----
H
S
A
T
A
Q
F
F
I
N
V
N
D
-----
N
----------------------
E
F
L
N
H
SSPTPQGW
G
Y
A
V
F
G
K
V
V
E
-
G
-
Q
D
I
V
D
K
I
K
A
V
K
T
-
G
-
S
-----HQ
D
V
P
N
D
D
V
V
I
E
K
A
V
V
V
------
62
PsiBlast_CBE
71.74
38%
-45
- C6 -
3R56
2
PPIF_HUMAN
A:
[19-160]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
100
PsiBlast_CBE
71.23
32%
-63
- C6 -
1C5F
1
CYP1_BRUMA
I:
[21-170]
--------------------------------------------------------------------------------------------------
G
R
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
--
L
M
L
C
T
GMAGTGKI
S
G
K
----
P
-----------
L
---------
H
--------
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
F
T
K
G
-
D
G
T
-
G
G
E
--
S
I
Y
G
G
---
M
F
D
D
E
E
F
V
M
K
H
D
E
P
F
V
-----------
V
S
M
A
-
N
K
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
T
T
P
A
---------------------------
P
H
L
N
N
--------
I
H
V
V
F
G
K
V
V
S
-
G
-
Q
E
V
V
T
K
I
E
Y
L
K
T
-
N
-
S
----
K
--
N
R
P
L
A
D
V
V
I
L
N
C
G
E
L
V
-----
97
PsiBlast_CBE
71.16
32%
-70
- C6 -
1C5F
2
CYP1_BRUMA
O:
[21-170]
--------------------------------------------------------------------------------------------------
G
R
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
--
L
M
LCTGMAGTGKI
S
G
K
----
P
-----------
L
---------
H
--------
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
F
T
K
G
-
D
G
T
-
G
G
E
--
S
I
Y
G
G
---
M
F
D
D
E
E
F
V
M
K
H
D
E
P
F
V
-----------
V
S
M
A
-
N
K
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
T
T
P
A
---------------------------
P
H
L
N
N
--------
I
H
V
V
F
G
K
V
V
S
-
G
-
Q
E
V
V
T
K
I
E
Y
L
K
T
-
N
-
S
----
K
--
N
R
P
L
A
D
V
V
I
L
N
C
G
E
L
V
-----
99
PsiBlast_CBE
71.09
32%
-65
- C6 -
1C5F
2
CYP1_BRUMA
K:
[21-170]
--------------------------------------------------------------------------------------------------
G
R
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
--
L
M
LCTGMAGTGKI
S
G
K
----
P
-----------
L
---------
H
--------
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
F
T
K
G
-
D
G
T
-
G
G
E
--
S
I
Y
G
G
---
M
F
D
D
E
E
F
V
M
K
H
D
E
P
F
V
-----------
V
S
M
A
-
N
K
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
T
T
P
A
---------------------------
P
H
L
N
N
--------
I
H
V
V
F
G
K
V
V
S
-
G
-
Q
E
V
V
T
K
I
E
Y
L
K
T
-
N
-
S
----
K
--
N
R
P
L
A
D
V
V
I
L
N
C
G
E
L
V
-----
78
PsiBlast_CBE
71.05
38%
-47
- C6 -
4J58
2
PPIF_HUMAN
A:
[17-158]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
61
PsiBlast_CBE
70.87
38%
-50
- C6 -
3R57
6
PPIF_HUMAN
A:
[19-160]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
60
PsiBlast_CBE
70.87
38%
-46
- C6 -
3R59
1
PPIF_HUMAN
A:
[19-160]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
67
PsiBlast_CBE
70.78
38%
-47
- C6 -
4O8H
2
PPIF_HUMAN
A:
[18-159]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
64
PsiBlast_CBE
70.75
38%
-48
- C6 -
3R4G
5
PPIF_HUMAN
A:
[19-160]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
56
PsiBlast_CBE
70.69
38%
-48
- C6 -
3RCL
2
PPIF_HUMAN
A:
[19-160]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
58
PsiBlast_CBE
70.60
38%
-46
- C6 -
3RCI
4
PPIF_HUMAN
X:
[19-160]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RA
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
65
PsiBlast_CBE
70.59
38%
-47
- C6 -
3R49
2
PPIF_HUMAN
A:
[19-160]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
101
PsiBlast_CBE
70.51
32%
-67
- C6 -
1C5F
2
CYP1_BRUMA
G:
[21-170]
--------------------------------------------------------------------------------------------------
G
R
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
--
L
M
LCTGMAGTGKI
S
G
K
----
P
-----------
L
---------
H
--------
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
F
T
K
G
-
D
G
T
-
G
G
E
--
S
I
Y
G
G
---
M
F
D
D
E
E
F
V
M
K
H
D
E
P
F
V
-----------
V
S
M
A
-
N
K
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
T
T
P
A
---------------------------
P
H
L
N
N
--------
I
H
V
V
F
G
K
V
V
S
-
G
-
Q
E
V
V
T
K
I
E
Y
L
K
T
-
N
-
S
----
K
--
N
R
P
L
A
D
V
V
I
L
N
C
G
E
L
V
-----
53
PsiBlast_CBE
70.44
38%
-47
- C6 -
3RDB
2
PPIF_HUMAN
A:
[19-160]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
34
PsiBlast_CBE
70.36
37%
-73
- C6 -
2CFE
3
?
A:
[16-162]
--------------------------------------------------------------------------------------------------
G
T
I
K
F
K
L
F
D
D
V
V
P
K
T
A
A
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
A
G
S
H
F
H
R
V
I
P
D
F
M
L
Q
G
G
D
F
T
A
G
-
N
G
T
-
G
G
K
--
S
I
Y
G
A
K
---------
F
A
D
E
N
F
Q
L
K
-
H
-
N
-
K
-
P
G
-
L
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
--------------------
T
V
V
T
S
W
-------
L
D
G
--------
K
H
V
V
F
G
E
V
I
D
-
G
-
M
N
V
V
K
A
I
E
A
-
E
G
-
S
-
G
----
S
--
G
K
P
R
S
R
I
E
I
A
K
C
G
V
C
------
86
PsiBlast_CBE
70.30
38%
-45
- C6 -
4TOT
2
PPIF_RAT
C:
[18-159]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RA
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
A
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
K
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
134
HHSearch
70.25
40%
-62
- C6 -
3PMP
1
?
A:
[11-163]
--------------------------------------------------------------------------------------
I
N
D
K
P
-----
E
-
G
R
I
V
F
K
L
Y
D
E
A
V
P
K
T
A
K
N
F
--
R
E
-----------
L
A
T
----
G
-----------
Q
---------
H
GFG-----
Y
K
D
S
I
F
H
R
V
I
P
Q
F
M
L
Q
G
G
D
-
F
T
R
H
N
G
T
-
G
G
K
--
S
I
Y
G
---------
E
K
F
A
D
E
N
F
Q
V
K
-
H
-
T
-
K
-
P
G
-
L
L
S
M
A
-
N
A
-
G
---
A
----
N
T
N
G
S
Q
F
F
I
T
T
V
P
-----
T
----------------------
S
W
L
D
G
--------
K
H
V
V
F
G
E
V
I
E
-
G
-
L
D
I
V
R
K
V
E
G
K
G
S
---
A
----
S
--
G
K
T
N
A
T
I
K
I
T
D
C
G
T
V
------
57
PsiBlast_CBE
70.21
38%
-46
- C6 -
3RCK
5
PPIF_HUMAN
X:
[19-160]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RA
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
54
PsiBlast_CBE
70.13
38%
-43
- C6 -
3RDA
7
PPIF_HUMAN
X:
[19-160]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RA
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
70
PsiBlast_CBE
70.10
38%
-45
- C6 -
4ZSC
1
?
A:
[17-158]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
77
PsiBlast_CBE
70.09
38%
-51
- C6 -
4J59
1
PPIF_HUMAN
A:
[17-158]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
91
PsiBlast_CBE
70.07
37%
-67
- C6 -
1VDN
2
CYPH_YEAST
A:
[16-156]
--------------------------------------------------------------------------------------------------
G
R
V
V
F
K
L
Y
N
D
I
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
A
G
S
P
F
H
R
V
I
P
D
F
M
L
Q
G
G
D
F
T
A
G
-
N
G
T
-
G
G
K
--
S
I
Y
G
G
K
---------
F
P
D
E
N
F
K
K
H
-
H
-
D
-
R
-
P
G
-
L
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
T
----------------
V
P
-----------
C
P
W
L
D
G
--------
K
H
V
V
F
G
E
V
V
D
-
G
-
Y
D
I
V
K
K
V
E
S
L
G
--
S
-
P
----
S
--
G
A
T
K
A
R
I
V
V
A
K
S
G
E
L
------
74
PsiBlast_CBE
70.04
38%
-49
- C6 -
4J5C
1
PPIF_HUMAN
X:
[17-158]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RA
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
52
PsiBlast_CBE
69.98
38%
-47
- C6 -
3RDC
1
PPIF_HUMAN
A:
[19-160]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
76
PsiBlast_CBE
69.93
38%
-46
- C6 -
4J5A
2
PPIF_HUMAN
X:
[17-158]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RA
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
102
PsiBlast_CBE
69.83
32%
-60
- C6 -
1C5F
3
CYP1_BRUMA
E:
[21-170]
--------------------------------------------------------------------------------------------------
G
R
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
--
L
M
LCTGMAGTGKI
S
G
K
----
P
-----------
L
---------
H
--------
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
F
T
K
G
-
D
G
T
-
G
G
E
--
S
I
Y
G
G
---
M
F
D
D
E
E
F
V
M
K
H
D
E
P
F
V
-----------
V
S
M
A
-
N
K
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
T
T
T
P
A
---------------------------
P
H
L
N
N
--------
I
H
V
V
F
G
K
V
V
S
-
G
-
Q
E
V
V
T
K
I
E
Y
L
K
T
-
N
-
S
----
K
--
N
R
P
L
A
D
V
V
I
L
N
C
G
E
L
V
-----
26
PsiBlast_CBE
69.83
37%
-68
- C6 -
1CYN
1
PPIB_HUMAN
A:
[20-161]
--------------------------------------------------------------------------------------------------
G
R
V
I
F
G
L
F
G
K
T
V
P
K
T
V
D
N
F
V
A
L
A
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
N
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
F
T
R
G
-
D
G
T
-
G
G
K
--
S
I
Y
G
E
R
---------
F
P
D
E
N
F
K
L
K
-
H
-
Y
-
G
-
P
G
-
W
V
S
M
A
-
N
A
-
G
---
K
----
D
T
N
G
S
Q
F
F
I
T
T
V
K
---------------------------
T
A
W
L
D
G
--------
K
H
V
V
F
G
K
V
L
E
-
G
-
M
E
V
V
R
K
V
E
S
T
K
T
-
D
-
S
----
R
--
D
K
P
L
K
D
V
I
I
A
D
C
G
K
I
E
V
E
K
P
F
69
PsiBlast_CBE
69.80
38%
-47
- C6 -
4ZSD
1
?
A:
[17-158]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
45
PsiBlast_CBE
69.76
32%
-65
- C6 -
1VAI
2
PPIA_ECOLI
B:
[1-165]
-----------------------------------------------------------------------
A
K
G
D
P
H
--------
V
L
L
T
T
S
-----
A
-
G
N
I
E
L
E
L
D
K
Q
K
A
P
V
S
V
Q
N
F
--
V
D
-----------
Y
V
N
----
S
-----------
G
---------
F
--------
Y
N
N
T
T
F
H
R
V
I
P
G
F
M
I
Q
G
G
G
----------------
F
T
E
Q
M
Q
Q
K
K
P
N
P
P
I
K
N
E
A
D
N
G
L
-
R
-
N
-
T
-
R
G
-
T
I
A
M
A
R
T
A
-
D
---
K
----
D
S
A
T
S
Q
F
F
I
N
V
A
D
N
AFL
D
H
G
Q
R
----------------------
D
F
--------
G
Y
A
V
F
G
K
V
V
K
-
G
-
M
D
V
A
D
K
I
S
Q
V
P
T
-
H
-
D
VGPY
Q
--
N
V
P
S
K
P
V
V
I
L
S
A
T
V
L
P
-----
85
PsiBlast_CBE
69.63
38%
-47
- C6 -
4TOT
4
PPIF_RAT
D:
[18-159]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RA
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
A
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
K
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
71
PsiBlast_CBE
69.49
38%
-44
- C6 -
4XNC
1
?
A:
[17-158]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
63
PsiBlast_CBE
69.49
38%
-47
- C6 -
3R54
1
PPIF_HUMAN
A:
[19-160]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
88
PsiBlast_CBE
69.46
38%
-46
- C6 -
4TOT
3
PPIF_RAT
A:
[18-159]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
A
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
K
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
55
PsiBlast_CBE
69.45
38%
-43
- C6 -
3RD9
2
PPIF_HUMAN
X:
[19-158]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RA
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
M
S
Y
--
68
PsiBlast_CBE
69.43
38%
-48
- C6 -
2BIU
4
PPIF_HUMAN
X:
[18-159]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RA
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
73
PsiBlast_CBE
69.41
38%
-48
- C6 -
4J5D
1
PPIF_HUMAN
X:
[17-158]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RA
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
59
PsiBlast_CBE
69.41
38%
-48
- C6 -
3RCF
2
PPIF_HUMAN
A:
[19-160]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
50
PsiBlast_CBE
69.38
38%
-46
- C6 -
2Z6W
1
PPIF_HUMAN
B:
[18-159]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RA
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
87
PsiBlast_CBE
69.30
38%
-47
- C6 -
4TOT
5
PPIF_RAT
B:
[18-159]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RA
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
A
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
K
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
75
PsiBlast_CBE
69.11
38%
-45
- C6 -
4J5B
1
PPIF_HUMAN
A:
[17-158]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
72
PsiBlast_CBE
69.09
38%
-48
- C6 -
4J5E
1
PPIF_HUMAN
X:
[17-158]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RA
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----
31
PsiBlast_CBE
68.45
34%
-69
- C6 -
1XQ7
1
?
C:
[20-166]
--------------------------------------------------------------------------------------------------
G
R
V
V
I
G
L
F
G
N
D
V
P
K
T
V
E
N
F
KQ
L
A
-----------
S
G
E
----
N
-----------
G
---------
F
G-------
Y
K
G
S
I
F
H
R
V
I
R
N
F
M
I
Q
G
G
D
F
T
N
F
-
D
G
T
-
G
G
K
--
S
I
Y
G
T
R
----------
F
D
D
E
N
L
K
I
-
K
-
H
-
F
-
V
G
-
A
V
S
M
A
-
N
A
-
G
---
P
----
N
S
N
G
S
Q
F
F
V
T
T
A
P
T
---------------------------
P
W
L
D
G
--------
R
H
V
V
F
G
K
V
V
E
-
G
-
M
D
V
V
K
K
V
E
N
T
K
T
-
G
-
L
----
N
--
D
K
P
K
K
A
V
K
I
N
D
C
G
V
L
------
32
PsiBlast_CBE
68.41
34%
-69
- C6 -
1XQ7
1
?
B:
[20-166]
--------------------------------------------------------------------------------------------------
G
R
V
V
I
G
L
F
G
N
D
V
P
K
T
V
E
N
F
KQ
L
A
-----------
S
G
E
----
N
-----------
G
---------
F
G-------
Y
K
G
S
I
F
H
R
V
I
R
N
F
M
I
Q
G
G
D
F
T
N
F
-
D
G
T
-
G
G
K
--
S
I
Y
G
T
R
----------
F
D
D
E
N
L
K
I
-
K
-
H
-
F
-
V
G
-
A
V
S
M
A
-
N
A
-
G
---
P
----
N
S
N
G
S
Q
F
F
V
T
T
A
P
T
---------------------------
P
W
L
D
G
--------
R
H
V
V
F
G
K
V
V
E
-
G
-
M
D
V
V
K
K
V
E
N
T
K
T
-
G
-
L
----
N
--
D
K
P
K
K
A
V
K
I
N
D
C
G
V
L
------
33
PsiBlast_CBE
68.30
34%
-68
- C6 -
1XQ7
1
?
A:
[20-166]
--------------------------------------------------------------------------------------------------
G
R
V
V
I
G
L
F
G
N
D
V
P
K
T
V
E
N
F
K
Q
L
A
-----------
S
G
E
----
N
-----------
G
---------
F
G-------
Y
K
G
S
I
F
H
R
V
I
R
N
F
M
I
Q
G
G
D
F
T
N
F
-
D
G
T
-
G
G
K
--
S
I
Y
G
T
R
----------
F
D
D
E
N
L
K
I
-
K
-
H
-
F
-
V
G
-
A
V
S
M
A
-
N
A
-
G
---
P
----
N
S
N
G
S
Q
F
F
V
T
T
A
P
T
---------------------------
P
W
L
D
G
--------
R
H
V
V
F
G
K
V
V
E
-
G
-
M
D
V
V
K
K
V
E
N
T
K
T
-
G
-
L
----
N
--
D
K
P
K
K
A
V
K
I
N
D
C
G
V
L
------
51
PsiBlast_CBE
68.18
38%
-45
- C6 -
2Z6W
3
PPIF_HUMAN
A:
[18-159]
--------------------------------------------------------------------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
G
E
----
K
-----------
G
---------
F
G-------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
N
H
-
N
G
T
-
G
G
K
--
S
I
Y
G
S
R
F
P
D
E
---
N
F
T
L
K
H
V
G
P
----------
G
-
V
L
S
M
A
-
N
A
-
G
---
P
----
N
T
N
G
S
Q
F
F
I
C
T
I
K
T
---
D
W
------------------------
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
-
G
-
M
D
V
V
K
K
I
E
S
F
G
--
S
-
K
----
S
--
G
R
T
S
K
K
I
V
I
T
D
C
G
Q
L
S
-----