@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1594: (2015-12-09 )
MSNYAIILAAGKGTRMKSDLPKVMHKVSGITMLEHVFRSVQAIEPSKIVTVIGHKAELVRDVLGDKSEFVMQTEQLGTGHAVMMAEEELATSKGHTLVIAGDTPLITGESLKNLIGFHVNHKNVATILTADAANPFGYGRIIRNSDDEVTKIVEQKDANDFEQQVKEINTGTYVFDNQSLFEALKDINTNNAQGEYYLTDVIGIFKEAGKKVGAYKLRDFDESLGVNDRVALATAEKVMRHRIARQHMVNGVTVVNPDSAYIDIDVEIGEESVIEPNVTLKGQTKIGKGTLLTNGSYLVDAQVGNDVTITNSMVEESIISDGVTVGPYAHIRPGTSLAKGVHIGNFVEVKGSQIGENTKAGHLTYIGNAEVGCDVNFGAGTITVNYDGQNKFKTEIGSNVFIGSNSTLIAPLEIGDNALTAAGSTITDNVPIDSIAIGRGRQVNKEGYANKKPHHPSQK
Atome Classification :
(50 SA)
-.........10......-..20........30........40........50....----....---60....-..-..----70........80........90.-.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220-.......230.......240.......250.......260..--------.....270.......280.......290.......300.......-310-........320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450........
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MS
N
Y
A
I
I
L
AAGKGTR
M
K
-
S
D
L
P
K
V
M
H
K
VS
G
I
T
M
L
E
H
V
F
R
S
V
QAIEPS
K
I
V
T
VIG
H
K
----
A
E
L
V
---
R
D
V
LG
D
-
K
S
-
E
F
----
V
M
Q
T
E
QLGTG
H
A
V
M
M
A
E
E
E
LATS-KG
H
T
L
V
I
AGDTPLI
T
G
E
S
L
K
N
L
I
G
FHVNHK
N
V
A
T
I
L
TADAANPFGY
G
R
I
IRNS
D
D
E
V
T
K
I
V
E
QKD
A
N
D
F
E
Q
Q
V
K
EINTG
T
Y
V
FD
N
Q
S
L
F
E
A
L
K
DINTNNAQG
E
Y
Y
L
T
D
V
I
G
I
F
K
E
AGKKVG
A
Y
KLRD
F
D
E
-SLGVND
R
V
A
L
A
T
A
E
K
V
M
R
H
R
I
A
R
Q
HMVN
G
V
T
V
VNPD
S
A
Y
I
D
I
--------
D
V
EIGEESVIEPN
V
T
L
K
GQTKIGK
G
T
L
LTNG
S
Y
L
V
D
A
QVG
N
D
V
T
I
-
T
-
N
-
S
M
V
E
E
S
I
ISDGVTVGPYAHIRPGTSLAKGVHIG
N
F
V
E
V
KGSQIGENTKAG
H
L
T
Y
IGNA
E
V
G
C
D
V
NFG
A
G
T
I
T
V
N
YDGQN
K
F
K
TEIG
S
N
V
F
IGSN
S
T
L
I
A
P
L
EIGDNALTAAGSTITDNVPID
S
I
AIGRGRQVNKEGYAN-KKPHHPSQK
1
PsiBlast_PDB
99.25
75%
-105
* C4 *
4AAW
2
GLMU_STRR6
A:
[2-459]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
-
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
----
A
E
L
V
---
E
E
V
L
A
E
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
---
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
--------
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
-
T
-
N
-
S
M
I
E
E
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
-
R
L
P
H
H
P
K
N
Q
2
PsiBlast_PDB
97.20
75%
-107
- C4 -
4AC3
2
GLMU_STRR6
A:
[2-459]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
-
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
----
A
E
L
V
---
E
E
V
L
A
E
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
--
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
--------
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
-
T
-
N
-
S
M
I
E
E
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
-
R
L
P
H
H
P
K
N
Q
6
PsiBlast_PDB
97.17
75%
-103
- C4 -
1HM8
2
GLMU_STRPN
A:
[11-468]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
-
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
----
A
E
L
V
---
E
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
--------
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
-
T
-
N
-
S
M
I
E
E
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
-
R
L
P
H
H
P
K
N
Q
22
PsiBlast_CBE
97.05
75%
-102
- C4 -
1HM8
2
GLMU_STRPN
B:
[11-468]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
-
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
----
A
E
L
V
---
E
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
--------
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
-
T
-
N
-
S
M
I
E
E
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
-
R
L
P
H
H
P
K
N
Q
86
HHSearch
97.04
76%
-104
- C4 -
1HM9
6
GLMU_STRPN
A:
[11-466]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
-
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
----
A
E
L
V
---
E
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
--------
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
-
T
-
N
-
S
M
I
E
E
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
-
R
L
P
H
H
P
K
N
Q
108
Fugue
96.84
75%
-103
- C4 -
1HM9
6
GLMU_STRPN
A:
[11-468]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
-
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
----
A
E
L
V
---
E
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
--------
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
-
T
-
N
-
S
M
I
E
E
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
-
R
L
P
H
H
P
K
N
Q
5
PsiBlast_PDB
96.84
75%
-103
- C4 -
1HM9
6
GLMU_STRPN
A:
[11-468]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
-
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
----
A
E
L
V
---
E
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
--------
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
-
T
-
N
-
S
M
I
E
E
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
-
R
L
P
H
H
P
K
N
Q
3
PsiBlast_PDB
96.50
75%
-107
- C4 -
1G95
-
GLMU_STRPN
A:
[2-452]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
-
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
----
A
E
L
V
---
E
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
------
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
--------
D
V
E
I
A
S
E
V
Q
I
E
A
N
V
T
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
-
T
-
N
-
S
M
I
E
E
S
S
V
A
D
G
V
I
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
N
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
-
R
L
-------
21
PsiBlast_CBE
96.09
75%
-101
- C4 -
1HM9
6
GLMU_STRPN
B:
[11-468]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
-
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
----
A
E
L
V
---
E
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
--------
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
-
T
-
N
-
S
M
I
E
E
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
-
R
L
P
H
H
P
K
N
Q
4
PsiBlast_PDB
95.15
75%
-105
- C4 -
1G97
3
GLMU_STRPN
A:
[2-447]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
-
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
----
A
E
L
V
---
E
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
--------
D
V
E
I
A
S
E
V
Q
I
E
A
N
V
T
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
-
T
-
N
-
S
M
I
E
E
S
S
V
A
D
G
V
I
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
N
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
-------------
23
PsiBlast_CBE
94.91
75%
-106
- C4 -
1HM0
2
GLMU_STRPN
B:
[11-456]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
-
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
----
A
E
L
V
---
E
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
------
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
--------
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
-
T
-
N
-
S
M
I
E
E
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
-------------
7
PsiBlast_PDB
94.70
75%
-106
- C4 -
1HM0
2
GLMU_STRPN
A:
[11-456]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
-
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
----
A
E
L
V
---
E
E
V
L
A
G
-
Q
T
-
E
F
----
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
------
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
--------
D
V
E
I
A
P
E
V
Q
I
E
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
-
T
-
N
-
S
M
I
E
E
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
-------------
18
PsiBlast_PDB
82.79
41%
-94
- C4 -
4K6R
6
GLMU_MYCTO
A:
[16-478]
------
L
V
L
A
A
G
P
G
T
R
M
R
-
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
P
Q
R
L
I
V
V
L
G
H
D
HQRI
A
P
L
V
G
E
L
A
D
T
L
G
R
-
T
I
-
D
V
----
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
G
L
S
A
L
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
T
H
R
A
V
S
A
A
V
T
V
L
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
Q
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
H
V
D
D
S
A
L
-
V
A
G
V
N
N
R
V
Q
L
A
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
T
T
W
I
D
V
--------
D
V
T
I
G
R
D
T
V
I
H
P
G
T
Q
L
L
G
R
T
Q
I
G
G
R
C
V
V
G
P
D
T
T
L
T
D
V
A
V
G
D
G
A
S
V
-
V
-
R
-
T
H
G
S
S
S
S
I
G
D
G
A
A
V
G
P
F
T
Y
L
R
P
G
T
A
L
G
A
D
G
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
Y
D
G
T
S
K
R
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
K
R
P
G
S
P
A
A
Q
12
PsiBlast_PDB
82.77
41%
-96
- C4 -
3ST8
7
GLMU_MYCTU
A:
[16-478]
------
L
V
L
A
A
G
P
G
T
R
M
R
-
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
P
Q
R
L
I
V
V
L
G
H
D
HQRI
A
P
L
V
G
E
L
A
D
T
L
G
R
-
T
I
-
D
V
----
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
G
L
S
A
L
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
T
H
R
A
V
S
A
A
V
T
V
L
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
Q
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
H
V
D
D
S
A
L
-
V
A
G
V
N
N
R
V
Q
L
A
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
T
T
W
I
D
V
--------
D
V
T
I
G
R
D
T
V
I
H
P
G
T
Q
L
L
G
R
T
Q
I
G
G
R
C
V
V
G
P
D
T
T
L
T
D
V
A
V
G
D
G
A
S
V
-
V
-
R
-
T
H
G
S
S
S
S
I
G
D
G
A
A
V
G
P
F
T
Y
L
R
P
G
T
A
L
G
A
D
G
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
Y
D
G
T
S
K
R
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
K
R
P
G
S
P
A
A
Q
15
PsiBlast_PDB
82.57
41%
-97
- C4 -
4G3P
6
?
A:
[16-478]
------
L
V
L
A
A
G
P
G
T
R
M
R
-
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
P
Q
R
L
I
V
V
L
G
H
D
HQRI
A
P
L
V
G
E
L
A
D
T
L
G
R
-
T
I
-
D
V
----
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
G
L
S
A
L
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
T
H
R
A
V
S
A
A
V
T
V
L
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
Q
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
H
V
D
D
S
A
L
-
V
A
G
V
N
N
R
V
Q
L
A
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
T
T
W
I
D
V
--------
D
V
T
I
G
R
D
T
V
I
H
P
G
T
Q
L
L
G
R
T
Q
I
G
G
R
C
V
V
G
P
D
T
T
L
T
D
V
A
V
G
D
G
A
S
V
-
V
-
R
-
T
H
G
S
S
S
S
I
G
D
G
A
A
V
G
P
F
T
Y
L
R
P
G
T
A
L
G
A
D
G
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
-------
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
K
R
P
G
S
P
A
A
Q
8
PsiBlast_PDB
82.48
41%
-97
- C4 -
3D8V
1
GLMU_MYCTU
A:
[10-472]
------
L
V
L
A
A
G
P
G
T
R
M
R
-
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
P
Q
R
L
I
V
V
L
G
H
D
HQRI
A
P
L
V
G
E
L
A
D
T
L
G
R
-
T
I
-
D
V
----
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
G
L
S
A
L
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
T
H
R
A
V
S
A
A
V
T
V
L
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
Q
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
H
V
D
D
S
A
L
-
V
A
G
V
N
N
R
V
Q
L
A
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
T
T
W
I
D
V
--------
D
V
T
I
G
R
D
T
V
I
H
P
G
T
Q
L
L
G
R
T
Q
I
G
G
R
C
V
V
G
P
D
T
T
L
T
D
V
A
V
G
D
G
A
S
V
-
V
-
R
-
T
H
G
S
S
S
S
I
G
D
G
A
A
V
G
P
F
T
Y
L
R
P
G
T
A
L
G
A
D
G
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
Y
D
-
T
S
K
R
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
K
R
P
G
S
P
A
A
Q
85
HHSearch
82.12
41%
-96
- C4 -
2V0H
11
GLMU_HAEIN
A:
[4-453]
-
K
A
L
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
----
G
D
L
M
---
R
T
H
L
A
N
E
Q
V
-
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
-
D
-
N
E
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
E
N
G
--
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
-
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
--------
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
-
K
P
Y
-
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
-
P
I
-------
14
PsiBlast_PDB
81.99
41%
-99
- C4 -
4HCQ
5
GLMU_MYCTU
A:
[16-470]
------
L
V
L
A
A
G
P
G
T
R
M
R
-
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
P
Q
R
L
I
V
V
L
G
H
D
HQRI
A
P
L
V
G
E
L
A
D
T
L
G
R
-
T
I
-
D
V
----
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
G
L
S
A
L
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
T
H
R
A
V
S
A
A
V
T
V
L
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
Q
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
H
V
D
D
S
A
L
-
V
A
G
V
N
N
R
V
Q
L
A
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
T
T
W
I
D
V
--------
D
V
T
I
G
R
D
T
V
I
H
P
G
T
Q
L
L
G
R
T
Q
I
G
G
R
C
V
V
G
P
D
T
T
L
T
D
V
A
V
G
D
G
A
S
V
-
V
-
R
-
T
H
G
S
S
S
S
I
G
D
G
A
A
V
G
P
F
T
Y
L
R
P
G
T
A
L
G
A
D
G
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
-------
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
K
--------
16
PsiBlast_PDB
81.77
41%
-96
- C4 -
4G3Q
5
GLMU_MYCTU
A:
[16-478]
------
L
V
L
A
A
G
P
G
T
R
M
R
-
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
P
Q
R
L
I
V
V
L
G
H
D
HQRI
A
P
L
V
G
E
L
A
D
T
L
G
R
-
T
I
-
D
V
----
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
G
L
S
A
L
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
T
H
R
A
V
S
A
A
V
T
V
L
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
Q
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
H
V
D
D
S
A
L
-
V
A
G
V
N
N
R
V
Q
L
A
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
T
T
W
I
D
V
--------
D
V
T
I
G
R
D
T
V
I
H
P
G
T
Q
L
L
G
R
T
Q
I
G
G
R
C
V
V
G
P
D
T
T
L
T
D
V
A
V
G
D
G
A
S
V
-
V
-
R
-
T
H
G
S
S
S
S
I
G
D
G
A
A
V
G
P
F
T
Y
L
R
P
G
T
A
L
G
A
D
G
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
Y
D
G
T
S
K
R
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
K
R
P
G
S
P
A
A
Q
11
PsiBlast_PDB
81.68
41%
-96
- C4 -
3SPT
5
GLMU_MYCTU
A:
[16-478]
------
L
V
L
A
A
G
P
G
T
R
M
R
-
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
P
Q
R
L
I
V
V
L
G
H
D
HQRI
A
P
L
V
G
E
L
A
D
T
L
G
R
-
T
I
-
D
V
----
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
G
L
S
A
L
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
T
H
R
A
V
S
A
A
V
T
V
L
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
Q
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
H
V
D
D
S
A
L
-
V
A
G
V
N
N
R
V
Q
L
A
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
T
T
W
I
D
V
--------
D
V
T
I
G
R
D
T
V
I
H
P
G
T
Q
L
L
G
R
T
Q
I
G
G
R
C
V
V
G
P
D
T
T
L
T
D
V
A
V
G
D
G
A
S
V
-
V
-
R
-
T
H
G
S
S
S
S
I
G
D
G
A
A
V
G
P
F
T
Y
L
R
P
G
T
A
L
G
A
D
G
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
Y
D
G
T
S
K
R
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
K
R
P
G
S
P
A
A
Q
17
PsiBlast_PDB
81.43
41%
-97
- C4 -
4G3S
7
GLMU_MYCTU
A:
[16-478]
------
L
V
L
A
A
G
P
G
T
R
M
R
-
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
P
Q
R
L
I
V
V
L
G
H
D
HQRI
A
P
L
V
G
E
L
A
D
T
L
G
R
-
T
I
-
D
V
----
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
G
L
S
A
L
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
T
H
R
A
V
S
A
A
V
T
V
L
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
Q
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
H
V
D
D
S
A
L
-
V
A
G
V
N
N
R
V
Q
L
A
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
T
T
W
I
D
V
--------
D
V
T
I
G
R
D
T
V
I
H
P
G
T
Q
L
L
G
R
T
Q
I
G
G
R
C
V
V
G
P
D
T
T
L
T
D
V
A
V
G
D
G
A
S
V
-
V
-
R
-
T
H
G
S
S
S
S
I
G
D
G
A
A
V
G
P
F
T
Y
L
R
P
G
T
A
L
G
A
D
G
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
-------
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
K
R
P
G
S
P
A
A
Q
34
PsiBlast_CBE
80.99
42%
-100
- C4 -
4KNX
8
GLMU_HAEIN
A:
[8-449]
-----
A
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
----
G
D
L
M
---
R
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
--
E
A
K
P
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
G
N
-
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
--
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
------
V
V
I
G
N
D
V
E
I
-
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
-
P
I
-------
37
PsiBlast_CBE
80.79
42%
-102
- C4 -
2W0W
2
GLMU_HAEIN
A:
[8-449]
-----
A
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
----
G
D
L
M
---
R
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
--
E
A
K
P
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
G
N
-
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
--
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
------
V
V
I
G
N
D
V
E
I
-
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
-
P
I
K
------
13
PsiBlast_PDB
80.68
41%
-98
- C4 -
4G87
5
GLMU_MYCTU
A:
[16-470]
------
L
V
L
A
A
G
P
G
T
R
M
R
-
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
P
Q
R
L
I
V
V
L
G
H
D
HQRI
A
P
L
V
G
E
L
A
D
T
L
G
R
-
T
I
-
D
V
----
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
G
L
S
A
L
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
T
H
R
A
V
S
A
A
V
T
V
L
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
Q
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
H
V
D
D
S
A
L
-
V
A
G
V
N
N
R
V
Q
L
A
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
T
T
W
I
D
V
--------
D
V
T
I
G
R
D
T
V
I
H
P
G
T
Q
L
L
G
R
T
Q
I
G
G
R
C
V
V
G
P
D
T
T
L
T
D
V
A
V
G
D
G
A
S
V
-
V
-
R
-
T
H
G
S
S
S
S
I
G
D
G
A
A
V
G
P
F
T
Y
L
R
P
G
T
A
L
G
A
D
G
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
-------
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
K
--------
32
PsiBlast_CBE
80.65
42%
-100
- C4 -
4KPZ
11
GLMU_HAEIN
A:
[8-449]
-----
A
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
----
G
D
L
M
---
R
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
--
E
A
K
P
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
G
N
-
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
--
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
------
V
V
I
G
N
D
V
E
I
-
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
-
P
I
-------
36
PsiBlast_CBE
80.60
42%
-104
- C4 -
4E1K
5
GLMU_HAEIN
A:
[8-449]
-----
A
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
----
G
D
L
M
---
R
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
--
E
A
K
P
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
G
N
-
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
--
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
------
V
V
I
G
N
D
V
E
I
-
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
-
P
I
-------
43
PsiBlast_CBE
80.36
42%
-99
- C4 -
2V0I
10
GLMU_HAEIN
A:
[8-449]
-----
A
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
----
G
D
L
M
---
R
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
--
E
A
K
P
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
G
N
-
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
--
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
------
V
V
I
G
N
D
V
E
I
-
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
-
P
I
K
------
33
PsiBlast_CBE
80.26
42%
-100
- C4 -
4KPX
11
GLMU_HAEIN
A:
[8-449]
-----
A
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
----
G
D
L
M
---
R
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
--
E
A
K
P
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
G
N
-
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
--
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
------
V
V
I
G
N
D
V
E
I
-
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
-
P
I
-------
42
PsiBlast_CBE
80.23
42%
-100
- C4 -
2V0J
12
GLMU_HAEIN
A:
[8-449]
-----
A
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
----
G
D
L
M
---
R
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
--
E
A
K
P
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
G
N
-
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
--
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
------
V
V
I
G
N
D
V
E
I
-
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
-
P
--------
35
PsiBlast_CBE
80.17
42%
-100
- C4 -
4KNR
9
GLMU_HAEIN
A:
[8-449]
-----
A
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
----
G
D
L
M
---
R
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
--
E
A
K
P
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
G
N
-
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
--
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
------
V
V
I
G
N
D
V
E
I
-
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
-
P
I
-------
40
PsiBlast_CBE
80.00
42%
-101
- C4 -
2V0L
11
GLMU_HAEIN
A:
[8-449]
-----
A
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
----
G
D
L
M
---
R
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
--
E
A
K
P
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
G
N
-
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
--
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
------
V
V
I
G
N
D
V
E
I
-
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
-
P
I
K
------
10
PsiBlast_PDB
79.88
41%
-93
- C4 -
3DJ4
3
GLMU_MYCTU
A:
[10-472]
------
L
V
L
A
A
G
P
G
T
R
M
R
-
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
P
Q
R
L
I
V
V
L
G
H
D
HQRI
A
P
L
V
GEL
A
D
T
L
G
R
-
T
I
-
D
V
----
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
G
L
S
A
L
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
T
H
R
A
V
S
A
A
V
T
V
L
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
Q
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
H
V
D
D
S
A
L
-
V
A
G
V
N
N
R
V
Q
L
A
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
T
T
W
I
D
V
--------
D
V
T
I
G
R
D
T
V
I
H
P
G
T
Q
L
L
G
R
T
Q
I
G
G
R
C
V
V
G
P
D
T
T
L
T
D
V
A
V
G
D
G
A
S
V
-
V
-
R
-
T
H
G
S
S
S
S
I
G
D
G
A
A
V
G
P
F
T
Y
L
R
P
G
T
A
L
G
A
D
G
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
-------
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
K
R
P
G
S
P
A
A
Q
41
PsiBlast_CBE
79.58
42%
-100
- C4 -
2V0K
11
GLMU_HAEIN
A:
[8-449]
-----
A
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
----
G
D
L
M
---
R
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
--
E
A
K
P
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
G
N
-
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
--
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
------
V
V
I
G
N
D
V
E
I
-
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
-
P
I
-------
31
PsiBlast_CBE
79.28
42%
-100
- C4 -
4KQL
11
GLMU_HAEIN
A:
[8-449]
-----
A
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
----
G
D
L
M
---
R
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
--
E
A
K
P
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
G
N
-
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
--
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
------
V
V
I
G
N
D
V
E
I
-
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
-
P
I
-------
38
PsiBlast_CBE
79.14
42%
-99
- C4 -
2W0V
10
GLMU_HAEIN
A:
[8-449]
-----
A
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
----
G
D
L
M
---
R
T
H
L
A
N
-
E
Q
V
N
W
----
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
-
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
--
E
A
K
P
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
E
N
G
N
-
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
-
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
--
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
------
V
V
I
G
N
D
V
E
I
-
K
-
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
G
W
Q
R
-
P
I
K
------
27
PsiBlast_CBE
78.87
41%
-94
- C4 -
2OI6
5
GLMU_ECOLI
A:
[9-452]
------
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
----
G
D
L
L
---
K
Q
A
L
K
D
-
D
N
L
N
W
----
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
-
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
--
R
D
A
K
P
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
-
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
--
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
------
S
V
I
G
D
D
C
E
I
-
S
-
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
V
-----
20
PsiBlast_PDB
78.28
41%
-94
- C4 -
2OI5
5
GLMU_ECOLI
A:
[9-452]
------
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
----
G
D
L
L
---
K
Q
A
L
K
D
-
D
N
L
N
W
----
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
-
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
--
R
D
A
K
P
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
-
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
--
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
------
S
V
I
G
D
D
C
E
I
-
S
-
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
------
29
PsiBlast_CBE
77.79
41%
-91
- C4 -
1HV9
5
GLMU_ECOLI
B:
[9-452]
------
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
----
G
D
L
L
---
K
Q
A
L
K
D
-
D
N
L
N
W
----
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
-
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
--
R
D
A
K
P
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
-
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
--
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
------
S
V
I
G
D
D
C
E
I
-
S
-
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
------
25
PsiBlast_CBE
77.78
41%
-92
- C4 -
2OI7
4
GLMU_ECOLI
A:
[9-452]
------
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
----
G
D
L
L
---
K
Q
A
L
K
D
-
D
N
L
N
W
----
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
-
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
--
R
D
A
K
P
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
-
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
--
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
------
S
V
I
G
D
D
C
E
I
-
S
-
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
------
26
PsiBlast_CBE
77.30
41%
-93
- C4 -
2OI6
7
GLMU_ECOLI
B:
[9-452]
------
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
----
G
D
L
L
---
K
Q
A
L
K
D
-
D
N
L
N
W
----
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
-
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
--
R
D
A
K
P
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
-
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
--
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
------
S
V
I
G
D
D
C
E
I
-
S
-
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
V
K
----
28
PsiBlast_CBE
77.21
41%
-93
- C4 -
2OI5
7
GLMU_ECOLI
B:
[9-452]
------
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
----
G
D
L
L
---
K
Q
A
L
K
D
-
D
N
L
N
W
----
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
-
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
--
R
D
A
K
P
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
-
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
--
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
------
S
V
I
G
D
D
C
E
I
-
S
-
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
------
109
Fugue
77.16
40%
-91
- C4 -
1HV9
4
GLMU_ECOLI
A:
[4-451]
-
N
A
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
----
G
D
L
L
---
K
Q
A
L
K
D
D
N
L
-
N
W
----
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
-
A
D
-
D
E
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
A
K
--
P
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
E
-
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
-
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
R
F
D
L
R
G
--------
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
S
V
I
G
D
D
C
E
I
S
P
-
Y
-
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
G
W
R
R
-
P
--------
19
PsiBlast_PDB
77.10
41%
-93
- C4 -
1HV9
4
GLMU_ECOLI
A:
[9-452]
------
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
----
G
D
L
L
---
K
Q
A
L
K
D
-
D
N
L
N
W
----
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
-
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
--
R
D
A
K
P
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
-
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
--
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
------
S
V
I
G
D
D
C
E
I
-
S
-
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
------
24
PsiBlast_CBE
76.32
41%
-92
- C4 -
2OI7
7
GLMU_ECOLI
B:
[9-452]
------
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
----
G
D
L
L
---
K
Q
A
L
K
D
-
D
N
L
N
W
----
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
-
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
--
R
D
A
K
P
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
-
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
--
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
------
S
V
I
G
D
D
C
E
I
-
S
-
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
------
45
PsiBlast_CBE
73.04
41%
-101
- C4 -
2QKX
1
GLMU_MYCTU
A:
[12-386]
------
L
V
L
A
A
G
P
G
T
R
M
R
-
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
P
Q
R
L
I
V
V
L
G
H
D
H
Q
R
I
A
P
L
V
G
E
L
A
D
T
L
G
R
-
T
I
-
D
V
----
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
G
L
S
A
L
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
T
H
R
A
V
S
A
A
V
T
V
L
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
Q
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
H
V
D
D
S
A
L
-
V
A
G
V
N
N
R
V
Q
L
A
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
T
T
W
I
D
V
--------
D
V
T
I
G
R
D
T
V
I
H
P
G
T
Q
L
L
G
R
T
Q
I
G
G
R
C
V
V
G
P
D
T
T
L
T
D
V
A
V
G
D
G
A
S
V
-
V
-
R
-
T
H
G
S
S
S
S
I
G
D
G
A
A
V
G
P
F
T
Y
L
R
P
G
T
A
L
G
A
D
G
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
-----------------------------------------------------------------------------------
111
Fugue
70.59
79%
-108
- C4 -
1G97
2
GLMU_STRPN
A:
[2-251]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S-
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
S
V
G
A
I
Q
P
E
K
T
V
T
V
V
G
H
K
----
A
E
L
V
---
E
E
V
L
A
--
G
----Q
T
E
F
V
T
Q
S
E
Q
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
L
-
S
G
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
K
N
V
A
T
I
L
T
A
E
T
D
N
P
F
G
Y
G
R
I
V
R
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
T
L
K
D
F
D
E
S-
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
A
T
Y
I
D
I
--------
D
V
E
I
A
S
E
V
Q
I
E
A
N
V
T
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
-
T
-
N
-
S
M
I
E
E
S
S
V
A
D
G
V
I
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
N
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
-------------
110
Fugue
63.32
34%
-91
- C4 -
1FXJ
2
GLMU_ECOLI
A:
[3-329]
N
N
A
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
----
G
D
L
L
---
K
Q
A
L
K
D
-
D
N
L
N
W
----
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
-
A
D
-
D
E
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
A
K
--
P
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
E
-
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
-
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
R
F
D
L
R
G
--------
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
S
V
I
G
D
D
C
E
I
S
P
-
Y
-
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
63.22
37%
-93
- C4 -
1FWY
4
GLMU_ECOLI
B:
[9-326]
------
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
----
G
D
L
L
---
K
Q
A
L
K
D
-
D
N
L
N
W
----
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
-
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
--
R
D
A
K
P
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
-
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
--
A
R
F
D
L
RGTLTHGR
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
------
S
V
I
G
D
D
C
E
I
-
S
-
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
---------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
63.17
37%
-96
- C4 -
1FWY
4
GLMU_ECOLI
A:
[9-328]
------
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
----
G
D
L
L
---
K
Q
A
L
K
D
-
D
N
L
N
W
----
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
-
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
--
R
D
A
K
P
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
-
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
--
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
------
S
V
I
G
D
D
C
E
I
-
S
-
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
-------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
61.81
37%
-94
- C4 -
1FXJ
2
GLMU_ECOLI
A:
[9-329]
------
V
I
L
A
A
G
K
G
T
R
M
Y
-
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
----
G
D
L
L
---
K
Q
A
L
K
D
-
D
N
L
N
W
----
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
-
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
--
R
D
A
K
P
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
-
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
--
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
------
S
V
I
G
D
D
C
E
I
-
S
-
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
------------------------------------------------------------------------------------------------------------------------------------