@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1619: (2015-12-09 )
MVFSVKTFNNINQIGLQELGNRFQIDGDMSENPDAYIIRSQNLHNQDFPSNLKAIARAGAGTNNIPIEEASAQGIVVFNTPGANANAVKEAVIAALLLSARDYLGANRWVNTLTGTDIPKQIEAGKKAFAGNEIAGKKLGVIGLGAIGARIANDARRLGMTVLGYDPYVSIETAWNISSHVQRVKEIKDIFETCDYITIHVPLTNETKHTFDAEAFSIMKKGTTIINFARAELVNNQELFKAIETGVVKRYITDFGDKELLNQKGITVFPHVGGSTDEAELNCAIMASQTIRCFMETGEITNSVNFPNVHQIQTAPFRITLINKNVPNIVAKISTAVSELGINIDNIINRSKGDYAYTLIDLDETDNNKISTLIEEFEGDENIVRVRLIAKQQ
Atome Classification :
(21 SA)
.........--10-.........20--.....----------.--------------.-----------.30.......--.40-.......----.---50-.........60........70........80........90........100.......110.......120...-----...-.130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250...---------.------.--------------------.----------------.-----------260-----.......270-.........280.......290.......300......------------------------------------------------------------------------------------------------------------------------.310..---------..--...320.......330.......340.......--350-.........360...--....370.......380.......390.----------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
F
S
V
KTFN--
N
--
I
N
Q
I
G
L
Q
E
LG
N
--
R
F
Q
ID----------G--------------D-----------MSENP
D
A
Y
I
I
--RSQ-NLHNQDF----
P
---
S
--
N
L
K
A
I
A
RAGAGTNNIPIEEASAQ
G
I
V
V
FNTPGA
N
A
N
A
V
K
E
A
V
I
A
A
L
L
L
S
A
R
D
Y
LGAN
R
W
V
NTLTGTDI
P
K
Q
I
E
AG-----KKA-FAGNEIAGK
K
L
G
V
I
G
L
G
A
I
G
A
R
I
A
N
D
A
R
R
L
G
M
T
V
LGYDP
Y
V
S
I
E
T
AWN
I
S
S
H
V
Q
R
V
K
E
I
K
D
I
F
ETC
D
Y
I
T
I
H
V
PLTNETKHTF
D
A
E
A
F
S
I
M
KKG
T
T
I
I
N
F
A
R
A
E
LV
N
N
Q
E
L
F
K
A
I
E
T
G
V
V
K
R
Y
I
T
DF---------G------
D
--------------------
K
----------------
E
-----------
L
LN-----QKG
I
T
V
FP---HVGGSTDEA
E
L
N
C
A
I
M
A
S
Q
T
I
R
C
F
M
ETGEITNSVNFPN------------------------------------------------------------------------------------------------------------------------
V
H
Q
I
QT---------A
P
--
F
R
I
T
L
INKN
V
P
N
I
V
A
K
I
S
T
A
V
S
E
LGI
N
I
D
N
I
IN--R---SKG
D
Y
A
Y
T
L
I
DLDET--DN
N
K
I
S
T
L
I
E
E
FEGDE
N
I
V
R
V
R
L
I
AKQQ----------------------------------------------------------------------------------------------------------------------------
28
HHSearch
88.86
27%
-95
* C1 *
1YGY
1
SERA_MYCTU
A:
[4-528]
-
L
P
V
V
L
I
A
D
--
K
--
L
A
P
S
T
V
A
A
L
G
D
--
Q
V
E
V
R
----------
W
--------------
V
DGPD
R
D
K
L
L
A
A
V
-
P
E
A
D
A
L
L
V
--
R
S
A
T
T
V
D
A
E
V
L
A
A
--
A
---
P
--
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
---------
T
W
K
-----
R
S
S
-
F
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
R
A
A
Q
--
L
G
I
E
-
L
L
S
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
---------
F
ATEPCT
D
--------------------
S
----------------
P
-----------
L
F
E
-----
L
A
Q
V
V
V
T
P
---
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
GVVNEEV
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
SDELPV
S
L
S
V
Q
V
R
G
ELAAEEV
E
V
L
R
L
S
A
L
R
G
L
F
SAVIEDAVTFVN
A
P
A
L
A
A
E
RG
V
T
A
E
I
C
K
A
SESPNHR
S
V
V
D
V
R
A
V
G
ADG
S
V
V
T
V
S
G
T
L
Y
G
PQLS
Q
K
I
V
Q
I
NG
R
H
F
D
L
R
A
Q
G
--
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
---
A
E
G
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
---
D
D
V
R
T
A
I
A
A
A
V
D
A
Y
K
L
E
V
V
D
L
S
-----------------------------------------------------------------------------------------------------------------------------
26
HHSearch
87.28
27%
-93
- C1 -
1SC6
1
SERA_ECOLI
A:
[4-404]
-
K
I
K
F
L
L
V
E
--
G
--
V
H
Q
K
A
L
E
S
L
R
A
A
-
G
Y
T
N
I
E
F
H
-------
K
G
A
L
D
D
E
--------
Q
L
K
E
S
-------
I
-
R
D
A
H
F
I
G
L
--
R
S
R
T
H
L
T
E
D
V
I
N
A
--
A
---
E
--
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
G
---------
V
G
N
-----------
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
I
E
N
K
L
P
L
-----
G
N
A
T
Q
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
-----------------DPFT----------------
S
----------------
P
-----------
L
A
E
-----
F
D
N
V
L
L
T
P
---
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
------------------------------------------------------------------------------------------------------------------------
V
S
L
P
L
H
---------
G
G
--
R
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
---
T
S
A
Q
M
G
Y
V
V
I
D
I
E
A
D
E
D
V
A
---
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
-------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
85.23
28%
-104
- C1 -
1SC6
1
SERA_ECOLI
A:
[47-403]
--------------------------------------------------------------------------
D
A
H
F
I
G
L
R
S
R
-
T
H
L
T
E
D
V
I
N
A
-
A
---
E
--
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
G
V
G
N
--------------------
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
----
I
E
N
K
L
P
L
G
N
A
T
Q
-
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
-------------------------------------------------------DPFTSP-----
L
A
E
-----
F
D
N
V
L
L
T
P
---
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
------------------------------------------------------------------------------------------------------------------------
V
S
L
P
L
H
---------
G
G
--
R
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
---
T
S
A
Q
M
G
Y
V
V
I
D
I
-
E
A
--
D
E
D
V
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
-------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
84.94
28%
-100
- C1 -
1YBA
7
SERA_ECOLI
A:
[53-409]
--------------------------------------------------------------------------
D
A
H
F
I
G
L
R
S
R
-
T
H
L
T
E
D
V
I
N
A
-
A
---
E
--
K
L
V
A
I
G
C
F
C
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
----
G
V
W
N
K
L
A
A
G
-------
S
-
F
---
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
----
I
E
N
K
L
P
L
G
N
A
T
Q
-
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
C
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
---------
F
------
P
--------------------
T
----------------
E
PATNS
D
P
F
T
S
P
L
C
E
-----
F
D
N
V
L
L
T
P
---
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
------------------------------------------------------------------------------------------------------------------------
V
S
L
P
L
H
---------
G
G
--
R
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
---
T
S
A
Q
M
G
Y
V
V
I
D
I
-
E
A
--
D
E
D
V
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
-------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.48
28%
-100
- C1 -
1PSD
2
SERA_ECOLI
A:
[52-408]
--------------------------------------------------------------------------
D
A
H
F
I
G
L
R
S
R
-
T
H
L
T
E
D
V
I
N
A
-
A
---
E
--
K
L
V
A
I
G
C
F
C
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
----
G
V
W
N
K
L
A
A
G
-------
S
-
F
---
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
----
I
E
N
K
L
P
L
G
N
A
T
Q
-
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
C
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
---------
F
------
P
--------------------
T
----------------
E
PATNS
D
P
F
T
S
P
L
C
E
-----
F
D
N
V
L
L
T
P
---
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
------------------------------------------------------------------------------------------------------------------------
V
S
L
P
L
H
---------
G
G
--
R
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
---
T
S
A
Q
M
G
Y
V
V
I
D
I
-
E
A
--
D
E
D
V
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
-------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
82.80
26%
-86
- C1 -
3K5P
4
?
A:
[15-416]
-
R
I
N
V
L
L
L
E
--
G
--
I
S
Q
T
A
V
E
Y
F
K
S
S
-
G
Y
T
N
V
----------
T
H
L
P
K
----------
A
L
D
K
A
D
L
I
K
A
--
I
-
S
S
A
H
I
I
G
I
--
R
S
R
T
Q
L
T
E
E
I
F
A
A
--
A
---
N
--
R
L
I
A
V
G
C
F
S
V
G
T
N
Q
V
E
L
K
A
A
R
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
I
I
M
L
M
R
R
I
F
P
R
S
V
S
A
H
A
G
---------
G
W
E
-----
K
T
A
-
I
G
S
R
E
V
R
G
K
T
L
G
I
V
G
Y
G
N
I
G
S
Q
V
G
N
L
A
E
S
L
G
M
T
V
R
Y
Y
D
T
S
D
K
L
Q
Y
-----
G
N
V
K
P
A
A
S
L
D
E
L
L
K
T
S
D
V
V
S
L
H
V
P
-----
S
K
L
I
T
E
A
K
L
R
K
M
K
K
G
A
F
L
I
N
N
A
R
G
S
D
V
D
L
E
A
L
A
K
V
L
Q
E
G
H
L
A
G
A
A
I
D
V
---------
F
------
P
VEPASNG
E
R
F
S
---------
T
----------------
P
-----------
L
Q
G
-----
L
E
N
V
I
L
T
P
---
H
I
G
G
S
T
E
E
A
Q
E
R
I
G
T
E
V
T
R
K
L
V
E
Y
S
D
V
G
S
T
V
G
A
V
N
F
P
Q
------------------------------------------------------------------------------------------------------------------------
V
Q
L
P
P
R
P--------
T
G
--
T
R
F
M
H
V
H
E
N
R
P
G
I
L
N
S
L
M
N
V
F
S
H
H
H
I
N
I
A
S
Q
F
L
--
Q
---
T
D
G
E
V
G
Y
L
V
M
E
A
D
G
V
G
E
A
S
---
D
A
V
L
Q
E
I
R
E
I
P
G
T
I
R
A
R
L
L
Y
-------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.10
28%
-99
- C1 -
2P9G
2
SERA_ECOLI
A:
[53-409]
--------------------------------------------------------------------------
D
A
H
F
I
G
L
R
S
R
-
T
H
L
T
E
D
V
I
N
A
-
A
---
E
--
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
----
G
V
W
N
K
L
A
A
G
-------
S
-
F
---
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
----
I
E
N
K
L
P
L
G
N
A
T
Q
-
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
---------
F
------
P
--------------------
T
----------------
E
PATNS
D
P
F
T
S
P
L
A
E
-----
F
D
N
V
L
L
T
P
---
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
------------------------------------------------------------------------------------------------------------------------
V
S
L
P
L
H
---------
V
V
--
R
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
---
T
S
A
Q
M
G
Y
V
V
I
D
I
-
E
A
--
D
E
D
V
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
-------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
82.06
26%
-98
- C1 -
3K5P
4
?
A:
[81-415]
--------------------------------------------------------------------------------------------------------
L
I
A
V
G
C
F
S
V
G
T
N
Q
V
E
L
K
A
A
R
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
I
I
M
L
M
R
R
I
F
--------------
P
R
S
V
S
A
H
A
GGWE
K
T
A
-
I
G
S
R
E
V
R
G
K
T
L
G
I
V
G
Y
G
N
I
G
S
Q
V
G
N
L
A
E
S
L
G
M
T
V
R
Y
Y
D
T
S
D
K
L
Q
Y
G
-----
N
V
K
P
A
A
S
L
D
E
L
L
K
T
S
D
V
V
S
L
H
V
P
-----
S
K
L
I
T
E
A
K
L
R
K
M
K
K
G
A
F
L
I
N
N
A
R
G
S
D
V
D
L
E
A
L
A
K
V
L
Q
E
G
H
L
A
G
A
A
I
D
V
FPVEPASN-
G
------
E
--------------------
R
F
S
T
-------------
P
-----------
L
Q
G
-----
L
E
N
V
I
L
T
P
---
H
I
G
G
S
T
E
E
A
Q
E
R
I
G
T
E
V
T
R
K
L
V
E
Y
S
D
V
G
S
T
V
G
A
V
N
F
P
Q
------------------------------------------------------------------------------------------------------------------------
V
-
Q
L
P
P
---------
R
P
T
G
T
R
F
M
H
V
H
E
N
R
P
G
I
L
N
S
L
M
N
V
F
S
H
H
H
I
N
I
A
S
Q
F
L
--
Q
---
T
D
G
E
V
G
Y
L
V
M
E
A
D
G
V
--
G
E
A
S
-
D
A
V
L
Q
E
I
R
E
I
P
G
T
I
R
A
R
L
L
Y
-------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.71
28%
-99
- C1 -
2P9C
2
SERA_ECOLI
A:
[53-409]
--------------------------------------------------------------------------
D
A
H
F
I
G
L
R
S
R
-
T
H
L
T
E
D
V
I
N
A
-
A
---
E
--
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
----
G
V
W
N
K
L
A
A
G
-------
S
-
F
---
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
----
I
E
N
K
L
P
L
G
N
A
T
Q
-
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
---------
F
------
P
--------------------
T
----------------
E
PATNS
D
P
F
T
S
P
L
A
E
-----
F
D
N
V
L
L
T
P
---
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
------------------------------------------------------------------------------------------------------------------------
V
S
L
P
L
H
---------
V
G
--
R
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
---
T
S
A
Q
M
G
Y
V
V
I
D
I
-
E
A
--
D
E
D
V
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
-------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.09
28%
-97
- C1 -
2P9E
6
SERA_ECOLI
A:
[53-409]
--------------------------------------------------------------------------
D
A
H
F
I
G
L
R
S
R
-
T
H
L
T
E
D
V
I
N
A
-
A
---
E
--
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
----
G
V
W
N
K
L
A
A
G
-------
S
-
F
---
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
----
I
E
N
K
L
P
L
G
N
A
T
Q
-
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
---------
F
------
P
--------------------
T
----------------
E
PATNS
D
P
F
T
S
P
L
A
E
-----
F
D
N
V
L
L
T
P
---
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
------------------------------------------------------------------------------------------------------------------------
V
S
L
P
L
H
---------
V
G
--
R
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
---
T
S
A
Q
M
G
Y
V
V
I
D
I
-
E
A
--
D
E
D
V
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
-------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.91
28%
-100
- C1 -
2PA3
2
SERA_ECOLI
A:
[53-409]
--------------------------------------------------------------------------
D
A
H
F
I
G
L
R
S
R
-
T
H
L
T
E
D
V
I
N
A
-
A
---
E
--
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
----
G
V
W
N
K
L
A
A
G
-------
S
-
F
---
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
----
I
E
N
K
L
P
L
G
N
A
T
Q
-
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
---------
F
------
P
--------------------
T
----------------
E
PATNS
D
P
F
T
S
P
L
A
E
-----
F
D
N
V
L
L
T
P
---
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
------------------------------------------------------------------------------------------------------------------------
V
S
L
P
L
H
---------
V
G
--
R
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
---
T
S
A
Q
M
G
Y
V
V
I
D
I
-
E
A
--
D
E
D
V
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
-------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
80.64
28%
-97
- C1 -
2DBQ
8
GYAR_PYRHO
A:
[1-326]
M
K
P
K
V
F
I
T
R
--
E
--
I
P
E
V
G
I
K
M
L
E
D
--
E
F
E
V
E
----------
V
W
G
D
EKEIP
R
E
I
L
L
K
K
-----------
V
-
K
E
V
D
A
L
V
T
--
M
L
S
E
R
I
D
K
E
V
F
E
N
--
A
---
P
--
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
G
--
V
A
W
H
-----
P
K
W
-
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
E
--
L
N
A
-
E
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
---------
F
------
E
EEPYYN--------------
E
----------------
E
-----------
L
F
K
-----
L
D
N
V
V
L
T
P
---
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
R
E
V
------------------------------------------------------------------------------------------------------------------------
I
K
I
R
K
P
---------
G
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
77.31
30%
-96
- C1 -
1WWK
1
?
A:
[4-307]
--
M
K
V
L
V
A
A
--
P
--
L
H
E
K
A
I
Q
V
L
K
D
A
-
G
L
E
V
I
----------
Y
E
E
YPD
E
D
-------
R
L
V
E
L
-------
V
-
K
D
V
E
A
I
I
V
--
R
S
K
P
K
V
T
R
R
V
I
E
S
--
A
---
P
--
K
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
E
G
---------
V
W
A
-----
K
K
E
-
A
M
G
I
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
I
L
L
Y
D
P
Y
P
N
E
E
R
A
K
E
--
V
N
G
K
-
F
V
D
L
E
T
L
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
---------
F
------
E
EEPLPKD-------------
H
----------------
P
-----------
L
T
K
-----
F
D
N
V
V
L
T
P
---
H
I
G
A
S
T
V
E
A
Q
E
R
A
G
V
E
V
A
E
K
V
V
K
I
L
K
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
77.30
25%
-97
- C1 -
1XDW
-
?
A:
[1-328]
--
M
K
V
L
C
Y
G
VR
D
--
V
E
L
P
I
F
E
A
C
N
K
EF
G
Y
D
I
K
----------
C
V
PDYLNT
K
------
E
T
A
E
M-------
A
-
A
G
F
D
A
V
I
L
--
R
G
N
C
F
A
N
K
Q
N
L
D
I
--
Y
K
K
-
L
--
G
V
K
Y
I
L
T
R
T
A
G
T
D
H
I
D
K
E
Y
A
K
E
L
G
F
P
M
A
F
V
P
R
Y
S
P
N
A
I
A
E
L
A
V
T
Q
A
M
M
L
L
R
H
T
A
Y
T
T
S
R
T
A
K
K
---------
N
F
K
-----
V
D
A
F
M
F
S
K
E
V
R
N
C
T
V
G
V
V
G
L
G
R
I
G
R
V
A
A
Q
I
F
H
G
M
G
A
T
V
I
G
E
D
V
F
E
I
K
G
I
E
----
D
Y
C
T
-
Q
V
S
L
D
E
V
L
E
K
S
D
I
I
T
I
H
A
P
Y
I
K
E
N
G
A
V
V
T
R
D
F
L
K
K
M
K
D
G
A
I
L
V
N
C
A
R
G
Q
L
V
D
T
E
A
V
I
E
A
V
E
S
G
K
L
G
G
Y
G
C
D
V
---------
L
------
D
--------------------
G
EASVFGKDLEGQKLEN
P
-----------
L
F
E
K
L
V
D
L
Y
P
R
V
L
I
T
P
---
H
L
G
S
Y
T
D
E
A
V
K
N
M
V
E
V
S
Y
Q
N
L
K
D
L
A
E
T
G
D
C
P
N
K
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
76.85
28%
-99
- C1 -
2G76
3
SERA_HUMAN
A:
[26-327]
-
L
R
K
V
L
I
S
D
--
S
--
L
D
P
C
C
R
K
I
L
Q
D
G
-
G
L
Q
V
V
----------
E
--------------
K
Q
NLS
K
E
E
L
I
A
E
L
-
Q
D
C
E
G
L
I
V
--
R
S
A
T
K
V
T
A
D
V
I
N
A
--
A
---
E
--
K
L
Q
V
V
G
R
A
G
T
G
V
D
N
V
D
L
E
A
A
T
R
K
G
I
L
V
M
N
T
P
N
G
N
S
L
S
A
A
E
L
T
C
G
M
I
M
C
L
A
R
Q
I
P
Q
A
T
A
S
M
K
D
G
---------
K
W
E
-----
R
K
K
-
F
M
G
T
E
L
N
G
K
T
L
G
I
L
G
L
G
R
I
G
R
E
V
A
T
R
M
Q
S
F
G
M
K
T
I
G
Y
D
P
I
I
S
P
E
V
S
A
S
--
F
G
V
Q
-
Q
L
P
L
E
E
I
W
P
L
C
D
F
I
T
V
H
T
P
L
L
P
S
T
T
G
L
L
N
D
N
T
F
A
Q
C
K
K
G
V
R
V
V
N
C
A
R
G
G
I
V
D
E
G
A
L
L
R
A
L
Q
S
G
Q
C
A
G
A
A
L
D
V
---------
F
------
T
EEPPRD--------------
R
----------------
A
-----------
L
V
D
-----
H
E
N
V
I
S
C
P
---
H
L
G
A
S
T
K
E
A
Q
S
R
C
G
E
E
I
A
V
Q
F
V
D
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
74.59
24%
-79
- C1 -
1YGY
1
SERA_MYCTU
A:
[3-529]
S
L
P
V
V
L
I
A
D
--
K
--
L
A
P
S
T
V
A
A
L
G
D
--
Q
V
E
V
R
W
V
DGPD
R
D
K
L
L
--------------
A
-----------
A
V
P
E
A
D
A
L
L
V
--
R
S
A
-
T
T
V
D
A
E
V
----
L
A
A
A
P
--
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
---------
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
K
-----
R
S
S
-
F
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
R
A
A
Q
L
G
I
---
E
L
L
S
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
FATEPC---
T
------
D
--------------------
S
----------------
P
-----------
L
F
E
-----
L
A
Q
V
V
V
T
P
---
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
------------------------------------------------------------------------------------------------------------------------
G
V
V
N
E
E
---------
V
A
--
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
--
A
EEV
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
--
I
E
D
A
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
K
A
S
E
SPNHR
S
V
V
D
V
R
A
V
G
ADG
S
V
V
T
V
S
G
T
L
Y
G
PQLSQKIVQING
R
H
F
D
L
R
AQ
G
I
N
L
I
I
H
Y
V
DRPG
A
L
G
K
I
G
T
L
L
G
T
A
GVNIQ
A
A
Q
L
S
E
D
AEGP
G
A
T
I
L
L
R
L
D
Q
D
V
P
D
D
V
R
T
A
I
A
A
A
VDAY
K
L
E
V
V
D
LS
36
HHSearch
74.24
20%
-104
- C1 -
3WWY
8
?
A:
[26-356]
-
K
T
K
I
I
F
F
D
--
I
K
D
Y
D
K
E
F
F
K
K
Y
G
A
DY
N
F
E
M
T
----------
F
L
KVRLTEETAN---
L
-----------
T
-
K
G
Y
D
V
V
C
G
--
F
A
N
D
N
I
N
K
E
T
I
D
I
M
A
E
---
N
--
G
I
K
L
L
A
M
R
C
A
G
F
N
N
V
S
L
K
D
V
N
E
R
-
F
K
V
V
R
V
P
A
Y
S
P
H
A
I
A
E
Y
T
V
G
L
I
L
A
V
N
R
K
I
N
K
A
Y
V
R
T
R
E
G
---------
N
F
S
-----
I
N
G
-
L
M
G
I
D
L
Y
E
K
T
A
G
I
I
G
T
G
K
I
G
Q
I
L
I
K
I
L
R
G
F
D
M
K
V
I
A
Y
D
L
F
P
N
Q
K
V
A
D
E
--
L
G
F
E
-
Y
V
S
L
D
E
L
Y
A
N
S
D
I
I
S
L
N
C
P
L
T
K
D
T
K
Y
M
I
N
R
R
S
M
L
K
M
K
D
G
V
I
L
V
N
T
G
R
G
M
L
I
D
S
A
D
L
V
E
A
L
K
D
K
K
I
G
A
V
A
L
D
V
---------
Y
------
E
EEENYFFEDKSTQVIED
D
I
L
G
----------------
R
-----------
L
L
S
-----
F
Y
N
V
L
I
T
S
---
H
Q
A
Y
F
T
K
E
A
V
G
A
I
T
V
T
T
L
N
N
I
K
D
F
V
E
G
R
P
L
V
N
E
V
P
Q
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.04
31%
-104
- C1 -
2EKL
1
?
A:
[46-308]
------------------------------------------------------------------------
N
Y
D
I
I
V
V
--
R
S
R
-
T
K
V
T
K
D
V
I
E
K
-
G
---
K
--
K
L
K
I
I
A
R
A
G
I
G
L
D
N
I
D
T
E
E
A
E
K
R
N
I
K
V
V
Y
A
P
G
A
S
T
D
S
A
V
E
L
T
I
G
L
M
I
A
A
A
R
K
M
Y
T
S
M
----
A
L
A
K
S
G
I
F
K
K
I
E
-------------
G
L
E
L
A
G
K
T
I
G
I
V
G
F
G
R
I
G
T
K
V
G
I
I
A
N
A
M
G
M
K
V
L
A
Y
D
I
L
D
I
R
E
K
A
E
K
I
N
A
K
A
V
S
L
E
E
L
---
L
K
N
S
D
V
I
S
L
H
V
T
V
S
K
D
A
K
P
I
I
D
Y
P
Q
F
E
L
M
K
D
N
V
I
I
V
N
T
S
R
A
V
A
V
N
G
K
A
L
L
D
Y
I
K
K
G
K
V
Y
A
Y
A
T
D
V
FWNEPPKE
E
W
------
E
--------------------
L
----------------
E
-----------
L
L
K
-----
H
E
R
V
I
V
T
T
---
H
I
G
A
Q
T
K
E
A
Q
K
R
V
A
E
M
T
T
Q
N
L
L
N
A
M
K
E
L
G
M
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
72.42
30%
-108
- C1 -
1YGY
-
SERA_MYCTU
A:
[46-314]
--------------------------------------------------------------------------
D
A
L
L
V
--
R
S
A
-
T
T
V
D
A
E
V
L
A
A
-
A
---
P
--
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
K
--------------
R
S
S
-
F
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
R
A
A
Q
L
G
I
E
L
L
---
S
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
FATEPC---
T
------
D
--------------------
S
----------------
P
-----------
L
F
E
-----
L
A
Q
V
V
V
T
P
---
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
------------------------------------------------------------------------------------------------------------------------
G
V
V
N
E
E
---------
V
A
--
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
--
A
---
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
--
S
A
V
I
E
D
A
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
K
----------------------------------------------------------------------------------------------------------------------------
39
HHSearch
71.87
20%
-99
- C1 -
1GDH
1
DHGY_HYPME
A:
[1-317]
-
K
K
K
I
L
I
T
W
--
P
--
L
P
E
A
A
M
A
R
A
R
E
--
S
Y
D
V
I
----------
A
HGDDPKIT
I
D
----
E
M
I
E
T
-------
A
-
K
S
V
D
A
L
L
I
--
T
L
N
E
K
C
R
K
E
V
I
D
R
I-
P
---
E
--
N
I
K
C
I
S
T
Y
S
I
G
F
D
H
I
D
L
D
A
C
K
A
R
G
I
K
V
G
N
A
P
H
G
V
T
V
A
T
A
E
I
A
M
L
L
L
L
G
S
A
R
R
A
G
E
G
E
K
M
I
R
T
R
S
W
P
------
G
W
E
-----
P
L
E
-
L
V
G
E
K
L
D
N
K
T
L
G
I
Y
G
F
G
S
I
G
Q
A
L
A
K
R
A
Q
G
F
D
M
D
I
D
Y
F
D
T
H
R
A
S
S
S
D
E
A
S
-
Y
Q
A
T
F
H
D
S
L
D
S
L
L
S
V
S
Q
F
F
S
L
N
A
P
S
T
P
E
T
R
Y
F
F
N
K
A
T
I
K
S
L
P
Q
G
A
I
V
V
N
T
A
R
G
D
L
V
D
N
E
L
V
V
A
A
L
E
A
G
R
L
A
Y
A
G
F
D
V
---------
F
------
A
GEPNIN--------------
E
----------------
G
-----------
Y
Y
D
-----
L
P
N
T
F
L
F
P
---
H
I
G
S
A
A
T
Q
A
R
E
D
M
A
H
Q
A
N
D
L
I
D
A
L
F
G
G
A
D
M
S
Y
A
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
69.51
30%
-96
- C1 -
4NJO
2
?
A:
[49-299]
-----------------------------------------------------------------------
K
D
A
D
G
V
I
V
--
R
S
D
-
K
I
D
E
E
I
I
----
K
---
A
G
E
K
V
K
I
I
V
R
A
G
A
G
Y
D
N
I
D
I
E
A
C
N
Q
G
K
I
V
V
M
N
T
P
G
Q
N
R
N
G
V
A
E
L
C
I
G
M
M
I
F
G
F
R
----------------------
K
G
-----
F
K
E
-
G
K
G
R
E
L
K
D
K
T
L
G
I
C
G
C
G
Y
V
G
K
R
V
K
E
I
A
E
G
I
G
M
K
I
K
V
Y
D
P
F
I
T
T
E
N
---------
Q
V
K
K
I
E
E
L
F
E
E
C
Q
V
I
S
L
H
L
P
L
T
K
E
T
K
G
K
I
G
Y
E
L
I
K
K
L
P
Y
G
G
M
I
C
N
T
A
R
K
E
I
I
D
E
E
G
L
I
R
I
M
R
E
R
E
D
L
I
Y
I
T
D
V
---------
A
PT----
S
--------------------
K
----------------
V
-----------
F
N
N
-----
E
F
K
G
R
F
F
A
T
PI
K
I
G
A
E
T
E
E
S
N
I
N
A
G
M
A
A
A
S
Q
I
C
D
F
F
T
N
G
T
V
K
F
Q
V
N
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------