@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1717: (2015-12-10 )
MTIKNLTVAGSGVLGSQIAFQAAYKGMSVTIYDINDEALNKGKERIKKLAKVYQSEIETAKEAYSDKAKSIKYNKNLLPSLDHIFLSKVADSLDLIADLPNQITFSKNLDQAVSDADLVIEAVPETVSIKEDFYKQLAKVAPSKTIFATNSSTLVPSQFADITGRPDKFLAMHFANNIWQNNIVEIMGHKGTDDEVVKEALAFSKDIGMVPLHIHKEQPGYILNSILVPFLESALALYYNKVSDSETIDKTWKLGTGAPMGPLEILDIIGIDTAYNIMKNYSDTNSDPNSLHAHLAKMLKEEFIDKGRTGKAAGHGFYDYD
Atome Classification :
(20 SA)
.........10........20........30........40..----......50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
I
K
N
L
T
V
AGSGVL
G
S
Q
I
A
F
Q
A
AYKG
M
S
V
T
I
Y
DI
N
D
E
A
L
N
K
G
K
----
E
R
I
K
K
L
A
K
V
Y
Q
S
E
I
E
T
A
K
E
A
Y
SD
K
A
K
S
I
KYNKNLL
P
S
L
D
H
I
F
L
S
K
V
A
D
S
L
D
L
I
A
DLPN
Q
I
TFSK
N
L
D
Q
AVS
D
A
D
L
V
I
E
AVPETV
S
I
K
E
D
F
Y
K
Q
L
A
KVAPS
K
T
I
F
ATNSSTLVP
S
Q
F
ADITGRP
D
K
F
L
A
M
H
F
A
N
N
I
W
Q
N
N
I
V
E
I
MGHKGT
D
D
E
V
V
K
E
A
L
A
FSKDI
G
M
V
P
L
H
I
HKEQP
G
Y
I
L
N
S
I
L
V
P
F
L
E
S
A
L
A
L
Y
Y
NKVSDSETIDKTWKLGTGAPM
G
P
L
E
I
L
D
I
IG
I
D
T
A
Y
N
I
M
K
NYSDTNSD
P
N
S
L
H
A
H
L
A
K
M
L
K
E
E
F
IDKGRTGKAAGHGFYDYD
1
PsiBlast_PDB
98.31
48%
-96
- C1 -
4DYD
14
?
A:
[4-283]
--
I
T
N
V
T
V
L
G
T
G
V
L
G
S
Q
I
A
F
Q
T
A
F
H
G
F
A
V
T
A
Y
D
I
N
T
D
A
L
D
A
A
K
----
K
R
F
E
G
L
A
A
V
Y
E
K
E
V
A
G
A
A
D
G
A
A
Q
K
A
L
-------------------------------
G
G
I
R
Y
S
D
D
L
A
Q
A
V
K
D
A
D
L
V
I
E
A
V
P
E
S
L
D
L
K
R
D
I
Y
T
K
L
G
E
L
A
P
A
K
T
I
F
A
T
N
S
S
T
L
L
P
S
D
L
V
G
Y
T
G
R
G
D
K
F
L
A
L
H
F
A
N
H
V
W
V
N
N
T
A
E
V
M
G
T
T
K
T
D
P
E
V
Y
Q
Q
V
V
E
F
A
S
A
I
G
M
V
P
I
E
L
K
K
E
K
A
G
Y
V
L
N
S
L
L
V
P
L
L
D
A
A
A
E
L
L
V
D
G
I
A
D
P
E
T
I
D
K
T
W
R
I
G
T
G
A
P
K
G
P
F
E
I
F
D
I
V
G
L
T
T
A
Y
N
I
-----
S
S
V
S
G
P
K
--
Q
R
E
F
A
A
Y
L
K
E
N
Y
I
D
K
G
K
L
G
L
A
T
G
E
G
F
Y
R
Y
-
3
PsiBlast_PDB
98.18
48%
-96
- C1 -
4E13
7
?
A:
[4-283]
--
I
T
N
V
T
V
L
G
T
G
V
L
G
S
Q
I
A
F
Q
T
A
F
H
G
F
A
V
T
A
Y
D
I
N
T
D
A
L
D
A
A
K
----
K
R
F
E
G
L
A
A
V
Y
E
K
E
V
A
G
A
A
D
G
A
A
Q
K
A
L
-------------------------------
G
G
I
R
Y
S
D
D
L
A
Q
A
V
K
D
A
D
L
V
I
E
A
V
P
E
S
L
D
L
K
R
D
I
Y
T
K
L
G
E
L
A
P
A
K
T
I
F
A
T
N
S
S
T
L
L
P
S
D
L
V
G
Y
T
G
R
G
D
K
F
L
A
L
H
F
A
N
H
V
W
V
N
N
T
A
E
V
M
G
T
T
K
T
D
P
E
V
Y
Q
Q
V
V
E
F
A
S
A
I
G
M
V
P
I
E
L
K
K
E
K
A
G
Y
V
L
N
S
L
L
V
P
L
L
D
A
A
A
E
L
L
V
D
G
I
A
D
P
E
T
I
D
K
T
W
R
I
G
T
G
A
P
K
G
P
F
E
I
F
D
I
V
G
L
T
T
A
Y
N
I
-----
S
S
V
S
G
P
K
--
Q
R
E
F
A
A
Y
L
K
E
N
Y
I
D
K
G
K
L
G
L
A
T
G
E
G
F
Y
R
Y
-
2
PsiBlast_PDB
98.08
48%
-99
- C1 -
4E12
9
?
A:
[4-283]
--
I
T
N
V
T
V
L
G
T
G
V
L
G
S
Q
I
A
F
Q
T
A
F
H
G
F
A
V
T
A
Y
D
I
N
T
D
A
L
D
A
A
K
----
K
R
F
E
G
L
A
A
V
Y
E
K
E
V
A
G
A
A
D
G
A
A
Q
K
A
L
-------------------------------
G
G
I
R
Y
S
D
D
L
A
Q
A
V
K
D
A
D
L
V
I
E
A
V
P
E
S
L
D
L
K
R
D
I
Y
T
K
L
G
E
L
A
P
A
K
T
I
F
A
T
N
S
S
T
L
L
P
S
D
L
V
G
Y
T
G
R
G
D
K
F
L
A
L
H
F
A
N
H
V
W
V
N
N
T
A
E
V
M
G
T
T
K
T
D
P
E
V
Y
Q
Q
V
V
E
F
A
S
A
I
G
M
V
P
I
E
L
K
K
E
K
A
G
Y
V
L
N
S
L
L
V
P
L
L
D
A
A
A
E
L
L
V
D
G
I
A
D
P
E
T
I
D
K
T
W
R
I
G
T
G
A
P
K
G
P
F
E
I
F
D
I
V
G
L
T
T
A
Y
N
I
-----
S
S
V
S
G
P
K
--
Q
R
E
F
A
A
Y
L
K
E
N
Y
I
D
K
G
K
L
G
L
A
T
G
E
G
F
Y
R
Y
-
5
PsiBlast_PDB
90.96
32%
-98
- C1 -
3HAD
1
HCDH_HUMAN
A:
[13-301]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
-----------------
L
S
T
I
A
T
S
T
D
A
A
S
--------------
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
13
PsiBlast_PDB
90.88
32%
-95
- C1 -
3HDH
1
HCDH_PIG
A:
[15-301]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
----
K
G
I
E
------
E
S
L
R
K
V
A
K
K
K
F
A
E
N
-----------
P
K
A
G
D
E
F
V
E
K
T
L
S
S
----------
I
S
T
S
T
D
A
A
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
I
D
G
W
H
E
M
D
S
Q
-
N
P
L
F
Q
P
S
P
A
M
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
20
PsiBlast_PDB
89.92
30%
-91
- C1 -
2HDH
1
HCDH_HUMAN
A:
[2-290]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
----
K
G
I
E
------
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
---------------------
G
D
E
F
V
A
K
T
L
S
T
I
A
T
S
T
D
A
A
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
29
PsiBlast_CBE
89.77
32%
-90
* C1 *
3HDH
1
HCDH_PIG
B:
[15-301]
--
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
----
K
G
I
E
------
E
S
L
R
K
V
A
K
K
K
F
A
E
N
-----------
P
K
A
G
D
E
F
V
E
K
T
L
S
S
----------
I
S
T
S
T
D
A
A
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
I
D
G
W
H
E
M
D
S
Q
-
N
P
L
F
Q
P
S
P
A
M
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
22
PsiBlast_CBE
89.59
32%
-98
- C1 -
3HAD
1
HCDH_HUMAN
B:
[13-301]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
KGIE
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
-----------------
L
S
T
I
A
T
S
T
D
A
A
S
--------------
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
19
PsiBlast_PDB
89.30
31%
-95
- C1 -
3RQS
5
HCDH_HUMAN
A:
[35-323]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
-----------------
L
S
T
I
A
T
S
T
D
A
A
S
--------------
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
10
PsiBlast_PDB
89.19
32%
-97
- C1 -
1F17
1
HCDH_HUMAN
A:
[13-301]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
C
V
E
K
T
-----------------
L
S
T
I
A
T
S
T
D
A
A
S
--------------
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
28
PsiBlast_CBE
89.08
32%
-96
- C1 -
1F12
1
HCDH_HUMAN
B:
[13-301]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
KGIE
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
C
V
E
K
T
-----------------
L
S
T
I
A
T
S
T
D
A
A
S
--------------
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
8
PsiBlast_PDB
88.86
32%
-94
- C1 -
1F12
1
HCDH_HUMAN
A:
[13-301]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
C
V
E
K
T
-----------------
L
S
T
I
A
T
S
T
D
A
A
S
--------------
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
25
PsiBlast_CBE
88.72
31%
-95
- C1 -
1LSJ
1
HCDH_HUMAN
B:
[13-301]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
KGIE
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
-----------------
L
S
T
I
A
T
S
T
D
A
A
S
--------------
V
V
H
S
T
D
L
V
V
E
A
I
V
Q
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
24
PsiBlast_CBE
88.56
31%
-94
- C1 -
1LSO
1
HCDH_HUMAN
B:
[13-301]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
KGIE
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
-----------------
L
S
T
I
A
T
S
T
D
A
A
S
--------------
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
A
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
23
PsiBlast_CBE
88.54
31%
-91
- C1 -
1M76
3
HCDH_HUMAN
B:
[13-301]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
KGIE
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
-----------------
L
S
T
I
A
T
S
T
D
A
A
S
--------------
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
C
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
9
PsiBlast_PDB
88.30
32%
-97
- C1 -
1F14
-
HCDH_HUMAN
A:
[13-301]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
C
V
E
K
T
-----------------
L
S
T
I
A
T
S
T
D
A
A
S
--------------
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
27
PsiBlast_CBE
88.21
32%
-95
- C1 -
1F17
1
HCDH_HUMAN
B:
[13-301]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
KGIE
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
C
V
E
K
T
-----------------
L
S
T
I
A
T
S
T
D
A
A
S
--------------
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
30
PsiBlast_CBE
88.04
31%
-91
- C1 -
1M75
3
HCDH_HUMAN
B:
[13-301]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
KGIE
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
-----------------
L
S
T
I
A
T
S
T
D
A
A
S
--------------
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
7
PsiBlast_PDB
87.64
31%
-96
- C1 -
1LSO
1
HCDH_HUMAN
A:
[13-301]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
-----------------
L
S
T
I
A
T
S
T
D
A
A
S
--------------
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
A
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K
6
PsiBlast_PDB
87.64
31%
-88
- C1 -
1M76
3
HCDH_HUMAN
A:
[13-301]
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
-----------------
L
S
T
I
A
T
S
T
D
A
A
S
--------------
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
C
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
E
M
D
A
E
-
N
P
L
H
Q
P
S
P
S
L
N
K
--
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
K