@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1724: (2015-12-10 )
MNSLNGETLLTGLIANPARHSLSPLMWNTSFQEKNMNYAYLTFEVEEGKLTEAVRGVRALGIRGVNVSMPFKQSVIPLLDDLSPQAKLVGAVNTIVNQGGTGRLVGHMTDGIGCFKALAAQGFSAKNKIVTIAGIGGSGKAVAVQAAMEGVAEIRLFNRNSSNYDKVIDLSDKIKKQFQIKVVVDYLENKTAFKDAIRTSHFYIDATSLGMRPLDNYSLINDPEILTPNLVVVDLVYKPKETALLRFVRQNGVKHAYNGLGMLIYQGAEAFQLITNQEMPISSVERVLQTEN
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80........90........100..-.....110.......120.......130.......140.......150.......160......-.170.......---180.......190.......200.......210.......220.......230---.........240.......250.......260.......270.......280.......290
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNSL
N
G
E
T
L
L
T
G
L
IANPARHSL
S
P
L
MWNTSFQEKNM
N
Y
A
Y
L
T
F
E
VEEG
K
L
T
E
A
V
R
G
V
R
A
LGIRGVNVSMP
F
K
Q
S
V
I
P
L
L
DDLS
P
Q
A
K
L
V
G
A
V
N
T
I
VNQGGT
G
R
L
-
V
GHMTD
G
I
G
C
F
K
A
L
A
AQGFSAKN
K
I
V
T
I
A
GIGGSGKA
V
A
V
Q
A
A
M
E
G
V
A
E
I
R
L
F
NRNSSNYD
K
V
I-
D
L
S
D
K
I
K
K
Q
F
Q
---
I
K
V
V
V
D
Y
LEN
K
T
A
F
K
D
A
IRT
S
H
F
Y
I
D
ATSLGMRPLDNYSLINDPEILTP
N
L
-----
V
V
V
D
L
V
YKP
K
E
T
A
L
L
R
F
V
R
QNG
V
K
H
A
YNG
L
G
M
L
I
YQGA
E
A
F
Q
L
ITNQEM
P
I
S
S
V
E
R
V
L
QTEN
2
PsiBlast_PDB
99.03
42%
-113
- C7 -
3TNL
3
AROE_LISMO
A:
[33-314]
---
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
D
G
V
--
L
-
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
-
K
T
V
E
K
I
N
S
K
T
D
---
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
-----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
L
F
---
26
PsiBlast_CBE
98.69
42%
-114
- C7 -
3TOZ
3
AROE_LISMO
C:
[33-314]
---
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
D
G
V
--
L
-
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
-
K
T
V
E
K
I
N
S
K
T
D
---
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
-----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
L
F
---
23
PsiBlast_CBE
98.67
42%
-112
- C7 -
3TOZ
2
AROE_LISMO
F:
[33-314]
---
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
D
G
V
--
L
-
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
-
K
T
V
E
K
I
N
S
K
T
D
---
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
-----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
L
F
---
72
HHSearch
98.61
42%
-110
* C7 *
3TNL
3
AROE_LISMO
A:
[31-314]
-
E
R
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
---
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
-
K
T
V
E
K
I
N
S
K
T
D
---
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
-----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
L
F
---
27
PsiBlast_CBE
98.53
42%
-116
- C7 -
3TOZ
4
AROE_LISMO
B:
[33-314]
---
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
D
G
V
--
L
-
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
-
K
T
V
E
K
I
N
S
K
T
D
---
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
-----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
L
F
---
29
PsiBlast_CBE
98.42
42%
-113
- C7 -
3TNL
3
AROE_LISMO
C:
[33-314]
---
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
D
G
V
--
L
-
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
-
K
T
V
E
K
I
N
S
K
T
D
---
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
-----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
L
F
---
30
PsiBlast_CBE
98.38
42%
-114
- C7 -
3TNL
2
AROE_LISMO
B:
[33-314]
---
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
D
G
V
--
L
-
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
-
K
T
V
E
K
I
N
S
K
T
D
---
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
-----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
L
F
---
28
PsiBlast_CBE
98.34
42%
-115
- C7 -
3TNL
2
AROE_LISMO
D:
[33-314]
---
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
D
G
V
--
L
-
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
-
K
T
V
E
K
I
N
S
K
T
D
---
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
-----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
L
F
---
25
PsiBlast_CBE
98.21
42%
-116
- C7 -
3TOZ
1
AROE_LISMO
D:
[33-314]
---
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
D
G
V
--
L
-
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
-
K
T
V
E
K
I
N
S
K
T
D
---
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
-----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
L
F
---
22
PsiBlast_CBE
97.97
42%
-113
- C7 -
3TOZ
2
AROE_LISMO
G:
[33-314]
---
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
D
G
V
--
L
-
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
-
K
T
V
E
K
I
N
S
K
T
D
---
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
-----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
L
F
---
24
PsiBlast_CBE
97.90
42%
-114
- C7 -
3TOZ
2
AROE_LISMO
E:
[33-314]
---
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
D
G
V
--
L
-
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
-
K
T
V
E
K
I
N
S
K
T
D
---
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
-----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
L
F
---
21
PsiBlast_CBE
97.78
42%
-114
- C7 -
3TOZ
3
AROE_LISMO
H:
[33-314]
---
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
D
G
V
--
L
-
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
-
K
T
V
E
K
I
N
S
K
T
D
---
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
-----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
L
F
---
1
PsiBlast_PDB
97.78
42%
-114
- C7 -
3TOZ
4
AROE_LISMO
A:
[33-314]
---
I
T
G
H
T
E
L
I
G
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
A
K
L
G
L
D
Y
V
Y
L
A
F
E
V
G
D
K
E
L
K
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
N
D
D
G
V
--
L
-
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
A
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
D
F
Y
A
N
A
E
-
K
T
V
E
K
I
N
S
K
T
D
---
C
K
A
Q
L
F
D
I
E
D
H
E
Q
L
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
K
P
F
E
G
E
T
L
L
P
S
A
D
M
L
R
P
E
L
-----
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
C
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
L
F
---
31
PsiBlast_CBE
95.58
40%
-113
- C7 -
3T4E
2
YDIB_SALTY
B:
[33-308]
---------
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
E
K
A
G
L
P
Y
T
Y
M
A
F
E
V
D
N
T
T
F
A
S
A
I
E
G
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
N
D
--
D
G
Y
L
-
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
K
E
S
G
F
D
M
R
G
K
T
M
V
L
L
G
A
G
G
A
A
T
A
I
G
A
Q
A
A
I
E
G
I
K
E
I
K
L
F
N
R
K
D
D
F
F
E
K
A
V
-
A
F
A
K
R
V
N
E
N
T
D
---
C
V
V
T
V
T
D
L
A
D
Q
H
A
F
T
E
A
L
A
S
A
D
I
L
T
N
G
T
K
V
G
M
K
P
L
E
N
E
S
L
I
G
D
V
S
L
L
R
P
E
L
-----
L
V
T
E
C
V
Y
N
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
K
-
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
E
L
W
T
G
K
A
F
P
L
D
Y
V
K
Q
V
M
G
F
--
6
PsiBlast_PDB
95.47
40%
-113
- C7 -
3T4E
2
YDIB_SALTY
A:
[33-308]
---------
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
E
K
A
G
L
P
Y
T
Y
M
A
F
E
V
D
N
T
T
F
A
S
A
I
E
G
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
N
D
--
D
G
Y
L
-
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
K
E
S
G
F
D
M
R
G
K
T
M
V
L
L
G
A
G
G
A
A
T
A
I
G
A
Q
A
A
I
E
G
I
K
E
I
K
L
F
N
R
K
D
D
F
F
E
K
A
V
-
A
F
A
K
R
V
N
E
N
T
D
---
C
V
V
T
V
T
D
L
A
D
Q
H
A
F
T
E
A
L
A
S
A
D
I
L
T
N
G
T
K
V
G
M
K
P
L
E
N
E
S
L
I
G
D
V
S
L
L
R
P
E
L
-----
L
V
T
E
C
V
Y
N
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
K
-
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
E
L
W
T
G
K
A
F
P
L
D
Y
V
K
Q
V
M
G
F
T
A
5
PsiBlast_PDB
95.30
39%
-111
- C7 -
1VI2
2
YDIB_ECOLI
A:
[11-285]
---------
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
E
K
A
G
L
P
F
T
Y
M
A
F
E
V
D
N
D
S
F
P
G
A
I
E
G
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
N
D
--
D
G
Y
L
-
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
K
E
S
G
F
D
I
K
G
K
T
M
V
L
L
G
A
G
G
A
S
T
A
I
G
A
Q
G
A
I
E
G
L
K
E
I
K
L
F
N
R
R
D
E
F
F
D
K
A
L
-
A
F
A
Q
R
V
N
E
N
T
D
---
C
V
V
T
V
T
D
L
A
D
Q
Q
A
F
A
E
A
L
A
S
A
D
I
L
T
N
G
T
K
V
G
M
K
P
L
E
N
E
S
L
V
N
D
I
S
L
L
H
P
G
L
-----
L
V
T
E
C
V
Y
N
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
K
-
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
T
L
W
T
G
K
D
F
P
L
E
Y
V
K
Q
V
M
G
F
G
A
3
PsiBlast_PDB
95.23
39%
-105
- C7 -
1NPD
1
YDIB_ECOLI
A:
[9-283]
---------
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
E
K
A
G
L
P
F
T
Y
M
A
F
E
V
D
N
D
S
F
P
G
A
I
E
G
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
N
D
--
D
G
Y
L
-
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
K
E
S
G
F
D
I
K
G
K
T
M
V
L
L
G
A
G
G
A
S
T
A
I
G
A
Q
G
A
I
E
G
L
K
E
I
K
L
F
N
R
R
D
E
F
F
D
K
A
L
-
A
F
A
Q
R
V
N
E
N
T
D
---
C
V
V
T
V
T
D
L
A
D
Q
Q
A
F
A
E
A
L
A
S
A
D
I
L
T
N
G
T
K
V
G
M
K
P
L
E
N
E
S
L
V
N
D
I
S
L
L
H
P
G
L
-----
L
V
T
E
C
V
Y
N
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
K
-
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
T
L
W
T
G
K
D
F
P
L
E
Y
V
K
Q
V
M
G
F
G
-
71
HHSearch
95.14
39%
-112
- C7 -
3T4E
2
YDIB_SALTY
A:
[30-309]
------
K
Y
E
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
E
K
A
G
L
P
Y
T
Y
M
A
F
E
V
D
N
T
T
F
A
S
A
I
E
G
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
N
D
---
D
G
Y
L
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
K
E
S
G
F
D
M
R
G
K
T
M
V
L
L
G
A
G
G
A
A
T
A
I
G
A
Q
A
A
I
E
G
I
K
E
I
K
L
F
N
R
K
D
D
F
F
E
K
A
V
-
A
F
A
K
R
V
N
E
N
T
D
---
C
V
V
T
V
T
D
L
A
D
Q
H
A
F
T
E
A
L
A
S
A
D
I
L
T
N
G
T
K
V
G
M
K
P
L
E
N
E
S
L
I
G
D
V
S
L
L
R
P
E
L
-----
L
V
T
E
C
V
Y
N
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
K
-
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
E
L
W
T
G
K
A
F
P
L
D
Y
V
K
Q
V
M
G
F
T
A
4
PsiBlast_PDB
94.70
39%
-112
- C7 -
1O9B
4
YDIB_ECOLI
A:
[9-283]
---------
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
E
K
A
G
L
P
F
T
Y
M
A
F
E
V
D
N
D
S
F
P
G
A
I
E
G
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
N
D
--
D
G
Y
L
-
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
K
E
S
G
F
D
I
K
G
K
T
M
V
L
L
G
A
G
G
A
S
T
A
I
G
A
Q
G
A
I
E
G
L
K
E
I
K
L
F
N
R
R
D
E
F
F
D
K
A
L
-
A
F
A
Q
R
V
N
E
N
T
D
---
C
V
V
T
V
T
D
L
A
D
Q
Q
A
F
A
E
A
L
A
S
A
D
I
L
T
N
G
T
K
V
G
M
K
P
L
E
N
E
S
L
V
N
D
I
S
L
L
H
P
G
L
-----
L
V
T
E
C
V
Y
N
P
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
C
K
-
T
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
T
L
W
T
G
K
D
F
P
L
E
Y
V
K
Q
V
M
G
F
G
-
74
HHSearch
86.81
36%
-98
- C7 -
1NVT
2
AROE_METJA
A:
[5-284]
-
S
M
I
N
A
K
T
K
V
I
G
L
I
G
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
K
D
K
G
L
N
Y
V
Y
V
A
F
D
V
L
P
E
N
L
K
Y
V
I
D
G
A
K
A
L
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
K
I
E
---
D
G
K
A
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
E
E
E
I
G
R
V
K
D
K
N
I
V
I
Y
G
A
G
G
A
A
R
A
V
A
F
E
L
A
K
D
N
--
N
I
I
I
A
N
R
T
V
E
---
K
A
E
-
A
L
A
K
E
I
A
E
K
L
N
KKF
G
E
E
----
V
K
-
F
S
G
L
D
V
D
L
D
G
V
D
I
I
I
N
A
T
P
I
G
M
Y
P
N
I
D
V
E
P
I
V
K
A
E
K
L
R
E
D
M
-----
V
V
M
D
L
I
Y
N
P
L
E
T
V
L
L
K
E
A
K
K
V
N
A
K
-
T
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
P
N
I
E
V
M
K
N
A
I
I
D
K
I
9
PsiBlast_PDB
85.50
35%
-101
- C7 -
2HK9
3
AROE_AQUAE
A:
[8-268]
---
I
N
A
Q
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
R
Y
A
G
L
N
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
F
E
--
N
G
K
A
-
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
E
G
-
A
K
V
F
L
W
N
R
T
K
---
E
K
A
I
-
K
L
A
Q
K
----
F
P
---
L
E
V
V
-------
N
S
P
E
E
V
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
-------
E
D
P
E
I
F
N
Y
D
L
IKKD
H
V
V
V
D
I
I
Y
--
K
E
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
L
R
34
PsiBlast_CBE
84.64
35%
-103
- C7 -
2HK9
2
AROE_AQUAE
B:
[8-268]
---
I
N
A
Q
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
R
Y
A
G
L
N
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
F
E
--
N
G
K
A
-
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
E
G
-
A
K
V
F
L
W
N
R
T
K
---
E
K
A
I
-
K
L
A
Q
K
----
F
P
---
L
E
V
V
-------
N
S
P
E
E
V
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
-------
E
D
P
E
I
F
N
Y
D
L
IKKDH
V
V
V
D
I
I
Y
--
K
E
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
L
-
32
PsiBlast_CBE
84.03
35%
-99
- C7 -
2HK9
2
AROE_AQUAE
D:
[8-268]
---
I
N
A
Q
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
R
Y
A
G
L
N
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
F
E
--
N
G
K
A
-
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
E
G
-
A
K
V
F
L
W
N
R
T
K
---
E
K
A
I
-
K
L
A
Q
K
----
F
P
---
L
E
V
V
-------
N
S
P
E
E
V
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
-------
E
D
P
E
I
F
N
Y
D
L
IKKDH
V
V
V
D
I
I
Y
--
K
E
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
--
36
PsiBlast_CBE
84.02
37%
-97
- C7 -
1NVT
2
AROE_METJA
B:
[7-271]
---
I
N
A
K
T
K
V
I
G
L
I
G
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
K
D
K
G
L
N
Y
V
Y
V
A
F
D
V
L
P
E
N
L
K
Y
V
I
D
G
A
K
A
L
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
K
I
E
--
D
G
K
A
-
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
E
E
E
I
G
R
V
K
D
K
N
I
V
I
Y
G
A
G
G
A
A
R
A
V
A
F
E
L
A
K
D
N
--
N
I
I
I
A
N
R
T
V
E
K
A
E
A
L
A
K
E
I
A
E
K
L
N
K
K
F
G
---
E
E
V
K
F
S
G
L
D
V
D
L
D
G
V
D
I
I
------
I
N
A
T
P
I
G
M
Y
P
N
I
D
V
E
P
I
V
K
A
E
K
L
R
E
D
M
-----
V
V
M
D
L
I
Y
N
P
L
E
T
V
L
L
K
E
A
K
K
V
N
A
K
-
T
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
P
N
I
E
V
M
K
N
A
I
I
D
K
I
33
PsiBlast_CBE
83.91
35%
-98
- C7 -
2HK9
2
AROE_AQUAE
C:
[8-268]
---
I
N
A
Q
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
R
Y
A
G
L
N
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
F
E
--
N
G
K
A
-
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
E
G
-
A
K
V
F
L
W
N
R
T
K
---
E
K
A
I
-
K
L
A
Q
K
----
F
P
---
L
E
V
V
-------
N
S
P
E
E
V
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
-------
E
D
P
E
I
F
N
Y
D
L
IKKDH
V
V
V
D
I
I
Y
--
K
E
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
--
86
HHSearch
83.40
36%
-91
- C7 -
2HK9
3
AROE_AQUAE
A:
[7-271]
--
M
I
N
A
Q
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
R
Y
A
G
L
N
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
F
E
---
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
E
G
A
-
K
V
F
L
W
N
R
T
K
E
---
K
A
I
-
K
L
A
Q
K
F
P
L
-------
E
V
-------
V
N
S
P
E
E
V
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
E
D
P
--
E
I
F
N
Y
D
L
I
K
K
D
H
-----
V
V
V
D
I
I
Y
K
--
E
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
L
R
75
HHSearch
77.68
30%
-85
- C7 -
2D5C
4
AROE_THET8
A:
[1-260]
-------
M
L
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
E
S
L
G
L
E
G
S
Y
E
A
W
D
T
P
L
E
A
L
P
G
R
L
K
E
V
R
-
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
Q
V
---
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
G
G
I
P
-
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
L
R
E
A
G
L
-
E
V
W
V
W
N
R
T
P
Q
---
R
A
L
-
A
L
A
E
E
F
G
L
-------
R
A
----
V
P
-
L
----
E
K
A
R
E
A
R
L
L
V
N
A
T
R
V
G
L
E
D
P
S
A
--
S
P
L
P
A
E
L
F
P
E
E
G
-----
A
A
V
D
L
V
Y
R
P
L
W
T
R
F
L
R
E
A
K
A
K
G
L
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
13
PsiBlast_PDB
75.16
31%
-85
- C7 -
3DOO
1
AROE_STAEQ
A:
[4-261]
-----------
A
V
I
G
N
P
I
S
H
S
L
S
P
L
M
H
H
A
N
F
Q
S
L
N
L
E
N
T
Y
E
A
I
N
V
P
V
N
Q
F
Q
D
I
K
K
I
I
S
E
K
S
I
D
G
F
N
V
T
I
P
H
K
E
R
I
I
P
Y
L
D
D
I
N
E
Q
A
K
S
V
G
A
V
N
T
V
L
V
K
--
D
G
K
W
-
I
G
Y
N
T
D
G
I
G
Y
V
N
G
L
K
Q
I
Y
E
G
I
E
D
A
Y
I
L
I
L
G
A
G
G
A
S
K
G
I
A
N
E
L
Y
K
I
V
R
P
T
L
T
V
A
N
R
T
M
S
R
F
N
----
N
W
S
L
N
I
N
--------
K
I
N
L
S
H
A
E
S
H
L
D
E
F
D
I
I
------
I
N
T
T
P
-----------
V
I
S
L
N
R
L
A
S
H
T
-----
L
V
S
D
I
V
Y
N
P
Y
K
T
P
I
L
I
E
A
E
Q
R
G
-
N
P
I
Y
N
G
L
D
M
F
V
H
Q
G
A
E
S
F
K
I
W
T
N
L
E
P
D
I
K
A
M
K
N
I
V
I
Q
K
L