@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1728: (2015-12-10 )
MISSYHRPTRALIDLEAIANNVKSVQEHIPSDKKTFAVVKANAYGHGAVEVSKYIESIVDGFCVSNLDEAIELRQAGIVKMILVLGVVMPEQVILAKNENITLTVASLEWLRLCQTSAVDLSGLEVHIKVDSGMGRIGVRQLDEGNKLISELGESGASVKGIFTHFATADEADNCKFNQQLTFFKDFISGLDNCPDLVHASNSATSLWHSETIFNAVRLGVVMYGLNPSGTDLDLPYPINPALSLESELVHVKQLHDGSQVGYGATYQVTGDEFVGTVPIGYADGWTRDMQGFSVIVNGELCEIIGRVSMDQMTIRLPQKYTIGTKVTLIGQQGSCNITTTDVAQKRQTINYEVLCLLSDRIPRYY
Atome Classification :
(26 SA)
.........10----........20........30..--......40........50..-.-.-..-.-.60........70........80...-......90......-.--.100.......110--.......--120.---..-....130.......140.-.-.....150--..-..-.---..--..-160.......170.......180.......190.---.---.---....200.......210-...--....-..220......-.-230...-.....240.......250.......260.......270.......280.......290.-.......300.......310.....---..---320.--......330.......340.......350.......360....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MISSYHR
P
T
R
A
----
L
I
D
L
E
A
I
A
N
N
V
K
S
V
Q
E
HIPSDK--
K
T
F
A
V
V
K
ANAYGH
G
A
V
E
V
S
K
-
Y
-
I
-
E
S
-
I
-
V
D
G
F
C
V
S
N
L
D
E
A
I
E
L
R
Q
A
G
I
V
K
-
M
I
L
-
V
L
G
VVMP
E
Q
V
I
L
AK-N--E
N
I
T
L
T
V
A
S
L
E
W
L
R
--
L
C
Q
TSAV--DLS
G
---
L
E
-
V
H
I
K
VDSGMGRI
G
V
R
QLD-
E
-
G
N
K
L
I
S
----
E
L-GE-S---GA--S
V
-
K
G
I
F
T
HFATADEADNCKFN
Q
Q
L
T
F
F
K
D
F
I
S
G
LDN---C---
P
---
D
L
VHASNS
A
T
SLW
H
S
---
E
T
I
--
F
N
A
V
-
R
L
G
V
V
M
YGLNP-S-G-TDLD-LPYPINP
A
L
S
L
E
S
E
L
V
H
V
K
QLHDGSQVGYG
A
T
Y
Q
VTGD
E
F
V
G
TVPIGYADGWTRDMQ-G-
F
S
V
I
VNG
E
L
C
E
I
I
G
RVSM
D
Q
M
T
I
RL---PQ---
K
Y
TI--G
T
K
V
T
L
I
GQQGSC
N
I
T
T
T
D
V
A
Q
K
RQTI
N
Y
E
V
L
C
L
LSDRIPRYY
21
PsiBlast_CBE
93.23
49%
-112
- C2 -
3E6E
2
?
C:
[2-370]
-
V
V
G
W
H
R
P
T
R
L
----
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
--
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
-
A
-
A
-
K
K
-
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
-
P
I
L
-
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
-
Q
--
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
AA
L
Q
Q
L
T
P
E
--
S
N
T
P
---
L
R
-
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
P
E
-
E
-
T
K
Q
A
V
R
----
F
V
-
Q
S
-
H
---
K
E
--
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
---
L
---
P
---
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
---
D
V
P
--
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
-
S
-
G
-
N
K
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
---
E
V
P
V
--
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
24
PsiBlast_CBE
93.19
49%
-110
- C2 -
3E5P
2
?
B:
[1-370]
M
V
V
G
W
H
R
P
T
R
L
----
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
--
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
-
A
-
A
-
K
K
-
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
-
P
I
L
-
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
-
Q
--
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
L
T
P
E
--
S
N
T
P
---
L
R
-
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
P
E
-
E
-
T
K
Q
A
V
R
----
F
V
-
Q
S
-
H
---
K
E
--
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
---
L
---
P
---
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
---
D
V
P
--
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
-
S
-
G
-
N
K
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
---
E
V
P
V
--
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
3
PsiBlast_PDB
93.09
45%
-108
- C2 -
1SFT
3
ALR_GEOSE
A:
[2-368]
--
N
D
F
H
R
D
T
W
A
----
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
-
L
-
E
A
-
G
-
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
-
P
I
L
-
V
L
G
A
S
R
P
A
D
A
A
L
A
A
-
Q
--
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
--
E
A
S
A
L
Y
S
--
G
P
F
P
---
I
H
-
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
D
E
E
-
E
-
T
K
R
I
V
A
----
L
I
-
E
R
-
H
---
P
H
--
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
---
R
---
P
---
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
---
D
R
T
--
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
-
S
P
G
-
I
K
P
L
-
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
---
P
L
P
V
--
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
25
PsiBlast_CBE
92.67
45%
-105
- C2 -
1SFT
3
ALR_GEOSE
B:
[2-368]
--
N
D
F
H
R
D
T
W
A
----
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
-
L
-
E
A
-
G
-
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
-
P
I
L
-
V
L
G
A
S
R
P
A
D
A
A
L
A
A
-
Q
--
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
--
E
A
S
A
L
Y
S
--
G
P
F
P
---
I
H
-
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
D
E
E
-
E
-
T
K
R
I
V
A
----
L
I
-
E
R
-
H
---
P
H
--
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
---
R
---
P
---
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
---
D
R
T
--
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
-
S
P
G
-
I
K
P
L
-
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
---
P
L
P
V
--
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
2
PsiBlast_PDB
92.32
49%
-104
- C2 -
3E6E
2
?
A:
[2-370]
-
V
V
G
W
H
R
P
T
R
L
----
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
--
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
-
A
-
A
-
K
K
-
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
-
P
I
L
-
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
-
Q
--
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
L
T
P
E
--
S
N
T
P
---
L
R
-
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
P
E
-
E
-
T
K
Q
A
V
R
----
F
V
-
Q
S
-
H
---
K
E
--
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
---
L
---
P
---
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
---
D
V
P
--
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
-
S
-
G
-
N
K
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
---
E
V
P
V
--
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
22
PsiBlast_CBE
92.31
49%
-105
- C2 -
3E6E
1
?
B:
[2-370]
-
V
V
G
W
H
R
P
T
R
L
----
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
--
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
-
A
-
A
-
K
K
-
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
-
P
I
L
-
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
-
Q
--
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
AA
L
Q
Q
L
T
P
E
--
S
N
T
P
---
L
R
-
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
P
E
-
E
-
T
K
Q
A
V
R
----
F
V
-
Q
S
-
H
---
K
E
--
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
---
L
---
P
---
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
---
D
V
P
--
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
-
S
-
G
-
N
K
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
---
E
V
P
V
--
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
23
PsiBlast_CBE
91.72
49%
-110
- C2 -
3E5P
6
?
C:
[1-370]
M
V
V
G
W
H
R
P
T
R
L
----
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
--
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
-
A
-
A
-
K
K
-
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
-
P
I
L
-
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
-
Q
--
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
AA
L
Q
Q
L
T
P
E
--
S
N
T
P
---
L
R
-
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
P
E
-
E
-
T
K
Q
A
V
R
----
F
V
-
Q
S
-
H
---
K
E
--
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
---
L
---
P
---
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
---
D
V
P
--
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
-
S
-
G
-
N
K
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
---
E
V
P
V
--
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
4
PsiBlast_PDB
91.71
45%
-106
- C2 -
1BD0
2
ALR_GEOSE
A:
[2-368]
--
N
D
F
H
R
D
T
W
A
----
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
-
L
-
E
A
-
G
-
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
-
P
I
L
-
V
L
G
A
S
R
P
A
D
A
A
L
A
A
-
Q
--
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
--
E
A
S
A
L
Y
S
--
G
P
F
P
---
I
H
-
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
D
E
E
-
E
-
T
K
R
I
V
A
----
L
I
-
E
R
-
H
---
P
H
--
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
---
R
---
P
---
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
---
D
R
T
--
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
-
S
P
G
-
I
K
P
L
-
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
---
P
L
P
V
--
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
1
PsiBlast_PDB
91.66
49%
-106
- C2 -
3E5P
5
?
A:
[2-370]
-
V
V
G
W
H
R
P
T
R
L
----
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
--
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
-
A
-
A
-
K
K
-
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
-
P
I
L
-
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
-
Q
--
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
L
T
P
E
--
S
N
T
P
---
L
R
-
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
P
E
-
E
-
T
K
Q
A
V
R
----
F
V
-
Q
S
-
H
---
K
E
--
F
L
W
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
---
L
---
P
---
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
---
D
V
P
--
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
-
S
-
G
-
N
K
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
---
E
V
P
V
--
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
41
HHSearch
91.25
46%
-108
- C2 -
1BD0
2
ALR_GEOSE
A:
[3-368]
---
D
F
H
R
D
T
W
A
----
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
-
T
-
A
-
L
E
-
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
-
P
I
L
-
V
L
G
A
S
R
P
A
D
A
A
L
A
A
-
Q
--
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
--
E
A
S
A
L
Y
S
--
G
P
F
P
---
I
H
-
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
D
-
E
-
E
E
T
K
R
I
V
A
L
---
I
E
-
R
H
-
P
---
H
F
--
V
L
-
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
---
R
---
P
---
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
---
D
R
T
--
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
-
S
-
P
-
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
---
P
L
P
V
--
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
39
HHSearch
91.15
49%
-106
- C2 -
3E5P
5
?
A:
[3-370]
--
V
G
W
H
R
P
T
R
L
----
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
T
--
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
A
V
E
S
A
K
-
A
-
A
-
K
K
-
G
G
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
-
P
I
L
-
I
L
S
V
V
D
L
A
Y
V
P
L
L
I
-
Q
--
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
--
A
A
L
Q
Q
L
T
PE
S
N
T
P
---
L
R
-
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
P
E
-
E
-
T
K
Q
A
V
R
F
---
V
Q
-
S
H
-
K
---
E
F
--
L
W
-
E
G
I
F
T
H
F
S
T
A
D
E
I
D
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
E
---
L
---
P
---
R
Y
V
H
V
S
N
S
A
T
A
L
W
H
P
---
D
V
P
--
G
N
M
I
-
R
Y
G
V
A
M
Y
G
L
N
P
-
S
-
G
-
N
K
L
A
-
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
-
G
-
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
---
A
E
---
E
V
P
V
--
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
Y
26
PsiBlast_CBE
91.09
45%
-105
- C2 -
1BD0
2
ALR_GEOSE
B:
[2-368]
--
N
D
F
H
R
D
T
W
A
----
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
-
L
-
E
A
-
G
-
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
-
P
I
L
-
V
L
G
A
S
R
P
A
D
A
A
L
A
A
-
Q
--
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
--
E
A
S
A
L
Y
S
--
G
P
F
P
---
I
H
-
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
D
E
E
-
E
-
T
K
R
I
V
A
----
L
I
-
E
R
-
H
---
P
H
--
F
V
L
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
---
R
---
P
---
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
---
D
R
T
--
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
-
S
P
G
-
I
K
P
L
-
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
---
P
L
P
V
--
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
6
PsiBlast_PDB
90.82
42%
-125
- C2 -
4ILS
-
ALR_GEOSE
A:
[2-368]
--
N
D
F
H
R
D
T
W
A
----
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
I
M
A
S
V
C
G
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
-
L
-
E
A
-
G
-
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
-
P
I
L
-
V
T
G
A
S
R
P
A
D
A
A
L
A
A
-
Q
--
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
--
E
A
S
A
L
Y
S
--
G
P
F
P
---
I
H
-
F
H
L
Y
M
D
T
G
M
G
---
V
K
D
E
E
-
E
-
T
K
R
I
V
A
----
L
I
-
E
R
-
H
---
P
H
--
F
V
L
E
G
L
W
T
W
F
------------
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
---
R
---
P
---
P
L
V
F
C
A
N
---
S
L
R
------
R
T
--
F
N
M
V
-
Q
F
G
I
A
M
Y
G
L
A
-------------
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
K
D
G
W
L
R
R
L
Q
-
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
L
M
D
M
C
M
I
R
L
---
P
G
---
P
L
P
V
--
G
T
K
V
T
L
I
G
R
Q
G
D
K
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
5
PsiBlast_PDB
89.16
43%
-110
- C2 -
3HA1
3
?
A:
[4-373]
--
A
P
F
Y
R
D
T
W
V
----
E
V
D
L
D
A
I
Y
N
N
V
T
H
I
K
E
F
I
P
S
D
V
--
E
I
F
A
V
V
K
G
N
A
Y
G
H
D
Y
V
P
V
A
K
-
I
A
L
-
E
A
-
G
-
A
T
R
L
A
V
A
F
L
D
E
A
L
V
L
R
R
A
G
I
T
A
-
P
I
L
-
V
L
G
P
S
P
P
R
D
I
N
V
A
A
-
E
--
N
D
V
A
L
T
V
F
Q
K
E
W
V
D
--
E
A
I
K
L
W
D
--
G
S
S
T
---
M
K
-
Y
H
I
N
F
D
S
G
M
G
R
I
G
I
R
E
R
K
-
E
-
L
K
G
F
L
K
----
S
L
E
G
A
-
P
---
F
L
--
E
L
-
E
G
V
Y
T
H
F
A
T
A
D
E
V
E
T
S
Y
F
D
K
Q
Y
N
T
F
L
E
Q
L
S
W
L
K
E
---
F
GVD
P
---
K
F
V
H
T
A
N
S
A
A
T
L
R
F
Q
---
G
I
T
--
F
N
A
V
-
R
I
G
I
A
M
Y
G
L
S
P
-
S
V
E
-
I
R
P
F
-
L
P
F
K
L
E
P
A
L
S
L
H
T
K
V
A
H
I
K
Q
V
I
K
G
D
G
I
S
Y
N
V
T
Y
R
T
K
T
E
E
W
I
A
T
V
A
I
G
Y
A
D
G
W
L
R
R
L
Q
-
G
-
F
E
V
L
V
N
G
K
R
V
P
I
V
G
R
V
T
M
D
Q
F
M
I
H
L
---
P
C
---
E
V
P
L
--
G
T
K
V
T
L
I
G
R
Q
G
D
E
Y
I
S
A
T
E
V
A
E
Y
S
G
T
I
N
Y
E
I
I
T
T
I
S
F
R
V
P
R
I
F
28
PsiBlast_CBE
85.97
40%
-104
- C2 -
3OO2
3
ALR1_STAAC
B:
[5-371]
-
S
D
K
Y
Y
R
S
A
Y
M
----
N
V
D
L
N
A
V
A
S
N
F
K
V
F
S
T
L
H
P
-
N
K
--
T
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
-
H
-
L
M
E
N
-
G
-
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
-
K
I
L
-
V
L
G
V
L
P
A
K
D
I
D
K
A
I
-
Q
--
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
E
A
I
K
N
I
S
------
K
K
---
L
W
-
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
D
T
K
-
T
-
Y
Q
E
V
I
E
----
I
I
-
Q
Q
-
Y
---
E
Q
--
L
V
F
E
G
V
F
T
H
F
A
C
A
D
E
P
G
D
M
T
-
T
E
Q
Y
Q
R
F
K
D
M
V
N
E
A
I
K
-------
P
---
E
Y
I
H
C
Q
N
S
A
G
S
L
L
M
D
---
C
Q
F
--
C
N
A
I
-
R
P
G
I
S
L
Y
G
Y
Y
P
-
S
-
E
Y
V
Q
Q
K
-
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
Q
A
-------------
D
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
-
G
-
S
F
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
---
Q
V
K
A
--
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
9
PsiBlast_PDB
85.41
40%
-108
- C2 -
3OO2
3
ALR1_STAAC
A:
[5-371]
-
S
D
K
Y
Y
R
S
A
Y
M
----
N
V
D
L
N
A
V
A
S
N
F
K
V
F
S
T
L
H
P
-
N
K
--
T
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
-
H
-
L
M
E
N
-
G
-
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
-
K
I
L
-
V
L
G
V
L
P
A
K
D
I
D
K
A
I
-
Q
--
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
E
A
I
K
N
I
S
G
E
--
Q
E
K
K
---
L
W
-
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
D
T
K
-
T
-
Y
Q
E
V
I
E
----
I
I
-
Q
Q
-
Y
---
E
Q
--
L
V
F
E
G
V
F
T
H
F
A
C
A
D
E
P
G
D
M
T
-
T
E
Q
Y
Q
R
F
K
D
M
V
N
E
A
I
K
-------
P
---
E
Y
I
H
C
Q
N
S
A
G
S
L
L
M
D
---
C
Q
F
--
C
N
A
I
-
R
P
G
I
S
L
Y
G
Y
Y
P
-
S
-
E
Y
V
Q
Q
K
-
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
Q
A
G
E
S
V
S
Y
G
--
Y
T
A
T
D
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
-
G
-
S
F
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
---
Q
V
K
A
--
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
27
PsiBlast_CBE
84.58
40%
-107
- C2 -
4A3Q
11
ALR1_STAAM
B:
[2-368]
-
S
D
K
Y
Y
R
S
A
Y
M
----
N
V
D
L
N
A
V
A
S
N
F
K
V
F
S
T
L
H
P
-
N
K
--
T
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
-
H
-
L
M
E
N
-
G
-
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
-
K
I
L
-
V
L
G
V
L
P
A
K
D
I
D
K
A
I
-
Q
--
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
E
A
I
K
N
I
S
G
E
--
Q
E
K
K
---
L
W
-
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
D
T
N
-
T
-
Y
Q
E
V
I
E
----
I
I
-
Q
Q
-
Y
---
E
Q
--
L
V
F
E
G
V
F
T
H
F
---------
T
-
T
E
Q
Y
Q
R
F
K
D
M
V
N
E
A
I
K
-------
P
---
E
Y
I
H
C
Q
N
S
A
G
S
L
L
M
D
---
C
Q
F
--
C
N
A
I
-
R
P
G
I
S
L
Y
G
Y
Y
P
-
S
-
E
Y
V
Q
Q
K
-
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
L
----------------
P
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
-
G
-
S
F
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
---
Q
V
K
A
--
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
13
PsiBlast_PDB
84.00
38%
-113
- C2 -
4LUS
1
?
B:
[7-370]
-------
P
T
W
A
----
E
I
N
L
D
N
L
R
F
N
L
N
N
I
K
N
L
L
E
E
D
I
--
K
I
C
G
V
I
K
A
D
A
Y
G
H
G
A
V
E
V
A
K
-
L
-
L
-
E
K
E
K
-
V
D
Y
L
A
V
A
R
T
A
E
G
I
E
L
R
Q
N
G
I
T
L
-
P
I
L
-
N
L
G
Y
T
P
D
E
A
F
E
D
S
I
-
K
--
N
K
I
T
M
T
V
Y
S
L
E
T
A
Q
--
K
I
N
E
I
A
K
--
S
L
G
E
---
K
A
C
V
H
V
K
I
D
S
-----
G
F
Q
P
N
E
-
E
-
S
V
Q
E
I
I
----
E
L
-
N
K
L
E
---
Y
I
--
D
L
-
E
G
M
F
T
H
F
A
T
A
D
E
---
E
Y
T
Y
K
Q
A
N
N
Y
K
F
M
S
D
K
L
D
E
---
A
---
G
VKI
A
I
K
H
V
S
N
S
A
A
I
M
D
C
P
---
D
L
R
--
L
N
M
V
-
R
A
G
I
I
L
Y
G
H
Y
P
-
S
-
D
-
D
V
F
K
-
D
R
L
E
L
R
P
A
M
K
L
K
S
K
I
G
H
I
K
Q
V
E
P
G
V
G
I
S
Y
G
L
K
Y
T
T
T
G
K
E
T
I
A
T
V
P
I
G
Y
A
D
G
F
T
R
I
Q
K
-
N
-
P
K
V
L
I
K
G
E
V
F
D
V
V
G
R
I
C
M
D
Q
I
M
V
R
I
---
D
K
---
D
I
D
I
KV
G
D
E
V
I
L
F
G
E
---
G
E
V
T
A
E
R
I
A
K
D
L
G
T
I
N
Y
E
V
L
C
M
I
S
R
R
V
D
R
V
Y
8
PsiBlast_PDB
83.97
40%
-109
- C2 -
4A3Q
10
ALR1_STAAM
A:
[2-368]
-
S
D
K
Y
Y
R
S
A
Y
M
----
N
V
D
L
N
A
V
A
S
N
F
K
V
F
S
T
L
H
P
-
N
K
--
T
V
M
A
V
V
K
A
N
A
Y
G
L
G
S
V
K
V
A
R
-
H
-
L
M
E
N
-
G
-
A
T
F
F
A
V
A
T
L
D
E
A
I
E
L
R
M
H
G
I
T
A
-
K
I
L
-
V
L
G
V
L
P
A
K
D
I
D
K
A
I
-
Q
--
H
R
V
A
L
T
V
P
S
K
Q
W
L
K
E
A
I
K
N
I
S
G
E
--
Q
E
K
K
---
L
W
-
L
H
I
K
L
D
T
G
M
G
R
L
G
I
K
D
T
N
-
T
-
Y
Q
E
V
I
E
----
I
I
-
Q
Q
-
Y
---
E
Q
--
L
V
F
E
G
V
F
T
H
F
-------
D
M
T
-
T
E
Q
Y
Q
R
F
K
D
M
V
N
E
A
I
K
-------
P
---
E
Y
I
H
C
Q
N
S
A
G
S
L
L
M
D
---
C
Q
F
--
C
N
A
I
-
R
P
G
I
S
L
Y
G
Y
Y
P
-
S
-
E
Y
V
Q
Q
K
-
V
K
V
H
L
K
P
S
V
Q
L
I
A
N
V
V
Q
T
K
T
------------------
T
T
I
A
L
L
P
I
G
Y
A
D
G
Y
L
R
I
M
Q
-
G
-
S
F
V
N
V
N
G
H
Q
C
E
V
I
G
R
V
C
M
D
Q
T
I
V
K
V
---
P
D
---
Q
V
K
A
--
G
D
S
V
I
L
I
D
N
H
R
E
S
P
Q
S
V
E
V
V
A
E
K
Q
H
T
I
N
Y
E
V
L
C
N
L
S
R
R
L
P
R
I
Y
12
PsiBlast_PDB
83.52
38%
-111
- C2 -
4LUT
2
?
A:
[7-370]
-------
P
T
W
A
----
E
I
N
L
D
N
L
R
F
N
L
N
N
I
K
N
L
L
E
E
D
I
--
K
I
C
G
V
I
K
A
D
A
Y
G
H
G
A
V
E
V
A
K
-
L
-
L
-
E
K
E
K
-
V
D
Y
L
A
V
A
R
T
A
E
G
I
E
L
R
Q
N
G
I
T
L
-
P
I
L
-
N
L
G
Y
T
P
D
E
A
F
E
D
S
I
-
K
--
N
K
I
T
M
T
V
Y
S
L
E
T
A
Q
--
K
I
N
E
I
A
K
--
S
L
G
E
---
K
A
C
V
H
V
K
I
D
-------
F
Q
P
N
E
-
E
-
S
V
Q
E
I
I
----
E
L
-
N
K
L
E
---
Y
I
--
D
L
-
E
G
M
F
T
H
F
A
T
A
D
E
V
S
K
E
Y
T
Y
K
Q
A
N
N
Y
K
F
M
S
D
K
L
D
E
---
A
---
G
VKI
A
I
K
H
V
S
N
S
A
A
I
M
D
C
P
---
D
L
R
--
L
N
M
V
-
R
A
G
I
I
L
Y
G
H
Y
P
-
S
-
D
-
D
V
F
K
-
D
R
L
E
L
R
P
A
M
K
L
K
S
K
I
G
H
I
K
Q
V
E
P
G
V
G
I
S
Y
G
L
K
Y
T
T
T
G
K
E
T
I
A
T
V
P
I
G
Y
A
D
G
F
T
R
I
Q
K
-
N
-
P
K
V
L
I
K
G
E
V
F
D
V
V
G
R
I
C
M
D
Q
I
M
V
R
I
---
D
K
---
D
I
D
I
K
V
G
D
E
V
I
L
F
G
E
---
G
E
V
T
A
E
R
I
A
K
D
L
G
T
I
N
Y
E
V
L
C
M
I
S
R
R
V
D
R
V
Y
43
HHSearch
83.19
37%
-106
- C2 -
3CO8
1
LYSR_OENOB
A:
[4-370]
--
E
A
I
H
R
S
T
R
I
----
E
F
S
K
S
S
L
A
Y
N
V
Q
Y
T
K
Q
V
S
G
-
A
K
--
T
L
W
L
A
V
K
S
N
A
Y
G
H
G
L
L
Q
V
S
K
-
I
-
A
-
R
E
-
C
G
V
D
G
L
A
V
S
V
L
D
E
G
I
A
I
R
Q
A
G
I
D
D
-
F
I
L
-
I
L
G
P
I
D
V
K
Y
A
P
I
A
S
-
K
--
Y
H
F
L
T
T
V
S
S
L
D
W
L
K
--
S
A
D
K
I
L
---
G
K
E
K
---
L
S
-
V
N
L
A
V
D
T
G
M
N
R
I
G
V
R
S
-
K
K
D
-
L
K
D
E
I
E
F
---
L
Q
E
H
S
-
D
---
H
F
--
S
Y
-
D
G
I
F
T
H
F
A
---------
F
Q
R
Q
K
N
R
W
Y
E
L
I
D
G
L
I
----
M
---
P
---
R
Y
V
H
V
M
N
S
G
A
A
M
Y
H
S
KEL
P
G
C
--
N
S
I
A
-
R
V
G
T
V
V
Y
G
V
E
P
-
S
-
E
-
G
V
L
G
-
P
I
D
K
L
K
P
V
F
E
L
K
S
A
L
T
F
V
K
K
I
P
A
G
E
G
I
S
Y
G
S
K
F
V
T
S
R
D
T
W
I
G
T
L
P
I
G
Y
G
D
G
W
L
A
E
Y
Q
-
D
-
F
Q
L
L
I
D
G
Q
K
C
R
Q
V
G
Q
I
A
M
D
Q
M
M
V
A
L
---
P
H
---
E
Y
P
I
--
G
T
E
V
T
L
I
G
K
S
G
K
Y
E
N
T
L
Y
D
L
H
K
H
S
G
V
P
P
W
K
I
T
V
A
F
S
D
R
L
K
R
M
V
11
PsiBlast_PDB
83.14
36%
-107
- C2 -
3CO8
1
LYSR_OENOB
A:
[3-368]
-
L
E
A
I
H
R
S
T
R
I
----
E
F
S
K
S
S
L
A
Y
N
V
Q
Y
T
K
Q
-
V
S
G
A
K
--
T
L
W
L
A
V
K
S
N
A
Y
G
H
G
L
L
Q
V
S
K
-
I
-
A
R
E
C
-
G
-
V
D
G
L
A
V
S
V
L
D
E
G
I
A
I
R
Q
A
G
I
D
D
-
F
I
L
-
I
L
G
P
I
D
V
K
Y
A
P
I
A
S
-
K
--
Y
H
F
L
T
T
V
S
S
L
D
W
L
K
------
S
A
D
--
K
I
L
G
KEK
L
S
-
V
N
L
A
V
D
T
G
M
N
R
I
G
V
R
S
K
K
-
D
-
L
K
D
E
I
E
----
F
L
-
Q
E
-
H
---
S
D
HF
S
Y
-
D
G
I
F
T
H
F
A
---------
F
Q
R
Q
K
N
R
W
Y
E
L
I
D
G
L
-
I
---
M
---
P
---
R
Y
V
H
V
M
N
S
G
A
A
M
Y
H
S
---
K
E
L
PG
C
N
S
I
A
R
V
G
T
V
V
Y
G
V
E
P
-
S
-
E
-
G
V
L
G
-
P
I
D
K
L
K
P
V
F
E
L
K
S
A
L
T
F
V
K
K
I
P
A
G
E
G
I
S
Y
G
S
K
F
V
T
S
R
D
T
W
I
G
T
L
P
I
G
Y
G
D
G
W
L
A
E
Y
Q
-
D
-
F
Q
L
L
I
D
G
Q
K
C
R
Q
V
G
Q
I
A
M
D
Q
M
M
V
A
L
---
P
H
---
E
Y
P
I
--
G
T
E
V
T
L
I
G
K
S
G
K
Y
E
N
T
L
Y
D
L
H
K
H
S
G
V
P
P
W
K
I
T
V
A
F
S
D
R
L
K
R
M
V
16
PsiBlast_PDB
76.19
30%
-106
- C2 -
1XFC
1
ALR_MYCTU
A:
[14-378]
----------
A
----
M
V
D
L
G
A
I
E
H
N
V
R
V
L
R
E
H
A
-
G
H
A
--
Q
L
M
A
V
V
K
A
D
G
Y
G
H
G
A
T
R
V
A
Q
T
A
-
L
-
G
A
-
G
-
A
A
E
L
G
V
A
T
V
D
E
A
L
A
L
R
A
D
G
I
T
A
-
P
V
L
-
A
W
--
L
H
P
P
G
I
D
F
G
P
-
A
L
L
A
D
V
Q
V
A
V
S
S
L
R
Q
L
D
--
E
L
-
L
H
A
V
--
R
R
T
G
RT-
A
T
-
V
T
V
K
V
D
T
G
L
N
R
N
G
V
G
P
A
Q
-
F
-
P
A
M
L
T
A
L
R
Q
-
A
M
-
A
E
-
D
---
A
V
--
R
L
-
R
G
L
M
S
H
M
-----
P
D
D
S
I
N
D
V
Q
A
Q
R
F
T
A
F
L
A
Q
A
R
E
---
Q
---
G
VRF
E
V
A
H
L
S
N
S
S
A
T
M
A
R
P
---
D
L
T
--
F
D
L
V
-
R
P
G
I
A
V
Y
G
L
S
P
-
V
-
P
-
A
L
G
D
-
M
G
--
L
V
P
A
M
T
V
K
C
A
V
A
L
V
K
S
I
R
A
G
E
G
V
S
Y
G
H
T
W
I
A
P
R
D
T
N
L
A
L
L
P
I
G
Y
A
D
G
V
F
R
S
L
G
-
G
R
L
E
V
L
I
N
G
R
R
C
P
G
V
G
R
I
C
M
D
Q
F
M
V
D
L
GPG
P
L
---
D
V
A
E
--
G
D
E
A
I
L
F
G
P
G
I
R
G
E
P
T
A
Q
D
W
A
D
L
V
G
T
I
H
Y
E
V
V
T
S
P
R
G
R
I
T
R
T
Y
45
HHSearch
74.93
30%
-100
- C2 -
1XFC
1
ALR_MYCTU
A:
[11-378]
-----------LAEA
M
V
D
L
G
A
I
E
H
N
V
R
V
L
R
E
H
A
G
-
H
A
--
Q
L
M
A
V
V
K
A
D
G
Y
G
H
G
A
T
R
V
A
Q
-
T
-
A
-
L
G
-
A
G
A
A
E
L
G
V
A
T
V
D
E
A
L
A
L
R
A
D
G
I
T
A
-
P
V
L
A
W
L
H
P
P
G
-
I
D
F
G
P
A
L
-
L
--
A
D
V
Q
V
A
V
S
S
L
R
Q
L
D
--
E
L
L
H
A
V
R
R
-
T
G
R
T
---
A
T
-
V
T
V
K
V
D
T
G
L
N
R
N
G
V
G
P
-
A
-
Q
-
F
P
A
M
L
T
A
L
R
Q
A
M
-
A
E
-
D
---
A
V
--
R
L
-
R
G
L
M
S
H
M
-----
P
D
D
S
I
N
D
V
Q
A
Q
R
F
T
A
F
L
A
Q
A
R
E
Q
GV
R
---
F
---
E
V
A
H
L
S
N
S
S
A
T
M
A
R
P
---
D
L
T
--
F
D
L
V
-
R
P
G
I
A
V
Y
G
L
S
P
-
V
-
P
---
A
L
-
G
D
M
G
L
V
P
A
M
T
V
K
C
A
V
A
L
V
K
S
I
R
A
G
E
G
V
S
Y
G
H
T
W
I
A
P
R
D
T
N
L
A
L
L
P
I
G
Y
A
D
G
V
F
R
S
L
G
G
R
-
L
E
V
L
I
N
G
R
R
C
P
G
V
G
R
I
C
M
D
Q
F
M
V
D
L
---
G
P
GPL
D
V
A
E
--
G
D
E
A
I
L
F
G
P
G
I
R
G
E
P
T
A
Q
D
W
A
D
L
V
G
T
I
H
Y
E
V
V
T
S
P
R
G
R
I
T
R
T
Y
32
Fugue
69.18
42%
-114
- C2 -
1BD0
1
ALR_GEOSE
A:
[12-244]
----------------
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
--D
T
H
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
-
T
-
A
-
L
E
-
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
-A
P
I
L
-
V
L
G
A
S
R
P
A
D
A
A
L
A
A
Q
---
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
--
E
A
S
A
L
Y
-----
S
G
P
F
P
I
H
-
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
D
E
E
-
E
-
T
K
R
I
V
A
----
L
I
-
E
---
R
HP
H
F
--
V
L
-
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
----R--
P
---
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
---
D
R
T
--
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
-
G
-
I
K
P
L
-
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
---
P
L
P
V
--
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
30
Fugue
65.88
40%
-105
- C2 -
1BD0
1
ALR_GEOSE
A:
[12-244]
----------------
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
T
--
H
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
-
T
-
A
-
L
E
-
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
-
P
I
L
-
V
L
G
A
S
R
P
A
D
A
A
L
A
A
-
Q
--
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
--
E
A
S
A
L
Y
S
--
G
P
F
P
---
I
H
-
F
H
L
K
M
D
T
G
M
G
R
L
G
V
K
D
E
E
-
E
-
T
K
R
I
V
A
----
L
I
-
E
R
H
P
---
H
F
--
V
L
-
E
G
L
Y
T
H
F
A
T
A
D
E
V
N
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
S
---
R
---
P
---
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
---
D
R
T
--
F
N
M
V
-
R
F
G
I
A
M
Y
G
L
A
P
S
P
-
G
-
I
K
P
L
-
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
-
H
-
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
---
P
G
---
P
L
P
V
--
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F