@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1730: (2015-12-10 )
MGFHQLSDKINIEILKQKTSLDLEVSQKKLAKEEELKNIIKGEDQRFLVIVGPCSADNPKAVLTYAKRLAKLEAAFKDKMFLVMRVYTAKPRTNGDGYKGLVHHSDKLGVFFQARKMHYDIIRETGLLTADELLYPEMLSVMDDLVSYYAIGARSVEDQGHRFISSGIDAPVGMKNPTSGNLRVMLNAVYAAQNQQELFYQNKQVRTDGNLLSHVILRGYHNADYRSIPNYHYENLLETITHYEETDLQNPFIVVDTNHDNSGKQFLEQIRIVKSVLADRQWHTKIRNYVRGFLIESYLEDGRQDKPDVFGKSITDPCLGWDKTEMLIRDIYNSL
Atome Classification :
(27 SA)
-.........10........20........30..---------......40-........50........60........70........80........90-........100.------...-------...110----.------..-------......120.......130.......140.......150.......160.......170.......180.......190.....---..200---..-----..-----.....210.......220.......230.......240.......250.......260--.........270.......280.......290.......300...----..----.----.310.......320.......330...-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
G
F
H
Q
LSDKI
N
I
E
I
L
KQKTSL
D
L
E
V
S
Q
K
K
LA
K
E
---------
E
E
L
K
N
I
IK-GED
Q
R
F
L
V
I
VGPCSADN
P
K
A
V
L
T
Y
A
K
R
L
A
K
L
E
A
A
F
KD
K
M
F
L
V
M
R
V
YTAKP-RTNGDGYK
G
L
VH------HSD-------KL
G
V
------
F
------
F
Q
-------
A
R
K
M
H
Y
D
I
I
R
ETGLL
T
A
D
E
L
L
Y
P
E
M
L
S
V
M
D
D
L
V
S
Y
Y
A
IGARS
V
E
D
Q
G
H
R
F
I
S
SGIDAPVGMKNPTSGN
L
R
V
M
L
N
A
V
YAAQ
N
Q
Q
E
---
L
F
Y-----QN-----KQ-----VRTD
G
N
L
L
S
H
V
I
L
R
GYHNADYRSIP
N
Y
H
Y
E
N
L
L
E
T
I
T
H
Y
E
ETDLQN
P
F
I
V
V
DTNHD----N
S
G
K
Q
F
L
E
Q
I
R
I
V
K
S
V
L
AD
R
Q
W
H
T
K
I
R
N
Y
V
R
G
F
L
I
E
S
Y
L
EDGRQD----KP----D----VFGKSITDPCLG
W
D
K
T
E
M
L
I
R
D
I
Y
NSL-----
93
Fugue
97.82
35%
-74
- C4 -
1QR7
3
AROG_ECOLI
A:
[8-350]
-
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
---------
K
A
I
H
K
I
L
K
-
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
DPHMDN
S
F
Q
-------
I
N
D
G
------
L
------
R
I
-------
A
R
K
L
L
L
D
I
N
D
-
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
---
F
L
S
-----
V
T
KWG
H
S
A
I
-----
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
E
------
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
-
P
A
Q
V
M
I
D
F
S
H
A
----
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
---
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
----
L
L
----
A
-----
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
A
R
R
G
37
PsiBlast_CBE
96.28
35%
-71
- C4 -
4HSO
4
?
C:
[5-336]
-----
Y
P
T
D
D
I
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
Q
E
I
S
D
L
V
H
-
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
L
D
G
T
------
F
D
I
N
F
G
L
R
Q
-------
A
R
S
L
L
L
S
-
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
---
F
L
G
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
-
I
D
C
S
H
A
----
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
---
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
----
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
-----
94
Fugue
95.70
34%
-79
- C4 -
1GG1
4
AROG_ECOLI
A:
[7-349]
D
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
---------
K
A
I
H
K
I
L
K
G-
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
--
G
W
K
G
L
I
N
DPHMDN
S
F
Q
-------
I
N
D
G
------
L
------
R
I
-------
A
R
K
L
L
L
D
I
N
D
S
-
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
---
F
L
S
V
T
KWG
H
S
-----
A
I
-----
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
----
E
--
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
-
V
M
I
D
F
S
H
A
NSSK----
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
---
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
----
L
P
----
L
----
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
A
R
R-
104
HHSearch
95.53
35%
-68
- C4 -
1N8F
4
AROG_ECOLI
A:
[8-345]
-
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
Q
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
---------
K
A
I
H
K
I
L
K
-
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
M
D
N
S
FQ
I
N
D
G
L
------
R
I
-------
A
R
K
L
L
L
D
I
N
-
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
-----
W
G
H
S
---
A
I
-----
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
------
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
-
L
P
A
Q
V
M
I
D
F
S
H
A
----
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
---
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
----
L
E
SGEP
L
----
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
-----
36
PsiBlast_CBE
95.47
35%
-70
- C4 -
4HSO
4
?
D:
[5-336]
-----
Y
P
T
D
D
I
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
ASGLVHRTR
Q
E
I
S
D
L
V
H
-
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
L
D
G
T
------
F
DINFGL
R
Q
-------
A
R
S
L
L
L
S
-
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
---
F
L
G
-----
V
T
-----
K
A
GHSAI
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
-
I
D
C
S
H
A
----
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
---
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
----
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
-----
5
PsiBlast_PDB
95.17
35%
-72
- C4 -
4HSO
4
?
A:
[6-336]
------
P
T
D
D
I
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
Q
E
I
S
D
L
V
H
-
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
L
D
G
T
------
F
D
I
N
F
G
L
R
Q
-------
A
R
S
L
L
L
S
-
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
---
F
L
G
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
-
I
D
C
S
H
A
----
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
---
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
----
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
-----
6
PsiBlast_PDB
94.27
35%
-68
- C4 -
4IXX
3
?
A:
[11-336]
-----------
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
Q
E
I
S
D
L
V
H
-
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
L
D
G
T
------
F
D
I
N
F
G
L
R
Q
-------
A
R
S
L
L
L
S
-
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
---
F
L
G
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
-
I
D
C
S
H
A
----
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
---
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
----
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
-----
38
PsiBlast_CBE
94.06
35%
-68
- C4 -
4HSO
4
?
B:
[8-336]
--------
D
D
I
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
Q
E
I
S
D
L
V
H
-
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
L
D
G
T
------
F
D
I
N
F
G
L
R
Q
-------
A
R
S
L
L
L
S
-
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
---
F
L
G
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
-
I
D
C
S
H
A
----
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
---
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
----
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
-----
34
PsiBlast_CBE
93.99
35%
-70
- C4 -
4IXX
3
?
C:
[11-336]
-----------
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
Q
E
I
S
D
L
V
H
-
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
L
D
G
T
------
F
D
I
N
F
G
L
R
Q
-------
A
R
S
L
L
L
S
-
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
---
F
L
G
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
-
I
D
C
S
H
A
----
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
---
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
----
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
-----
1
PsiBlast_PDB
93.90
35%
-69
- C4 -
4HSN
3
?
A:
[10-336]
----------
I
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
Q
E
I
S
D
L
V
H
-
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
L
D
G
T
------
F
D
I
N
F
G
L
R
Q
-------
A
R
S
L
L
L
S
-
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
---
F
L
S
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
-
I
D
C
S
H
A
----
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
---
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
----
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
-----
26
PsiBlast_CBE
93.84
35%
-66
- C4 -
4UMB
3
?
B:
[17-336]
-----------------
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
Q
E
I
S
D
L
V
H
-
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
L
D
G
T
------
F
D
I
N
F
G
L
R
Q
-------
A
R
S
L
L
L
S
-
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
---
F
L
S
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
-
I
D
C
S
H
A
----
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
---
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
----
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
-----
35
PsiBlast_CBE
93.75
35%
-68
- C4 -
4IXX
2
?
B:
[12-336]
------------
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
Q
E
I
S
D
L
V
H
-
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
L
D
G
T
------
F
D
I
N
F
G
L
R
Q
-------
A
R
S
L
L
L
S
-
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
---
F
L
G
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
-
I
D
C
S
H
A
----
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
---
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
----
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
-----
33
PsiBlast_CBE
93.62
35%
-68
- C4 -
4IXX
3
?
D:
[9-336]
---------
D
I
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
ASGLVHRTR
Q
E
I
S
D
L
V
H
-
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
L
D
G
T
------
F
DINFGL
R
Q
-------
A
R
S
L
L
L
S
-
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
---
F
L
G
-----
V
T
-----
K
A
GHSAI
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
-
I
D
C
S
H
A
----
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
---
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
----
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
-----
28
PsiBlast_CBE
93.43
35%
-68
- C4 -
4UMA
2
?
C:
[16-336]
----------------
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
ASGLVHRTR
Q
E
I
S
D
L
V
H
-
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
L
D
G
T
------
F
DINFGL
R
Q
-------
A
R
S
L
L
L
S
-
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
---
F
L
S
-----
V
T
-----
K
A
GHSAI
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
-
I
D
C
S
H
A
----
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
---
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
----
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
-----
31
PsiBlast_CBE
93.39
35%
-70
- C4 -
4HSN
3
?
C:
[10-336]
----------
I
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
ASGLVHRTR
Q
E
I
S
D
L
V
H
-
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
L
D
G
T
------
F
DINFGL
R
Q
-------
A
R
S
L
L
L
S
-
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
---
F
L
S
-----
V
T
-----
K
A
GHSAI
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
-
I
D
C
S
H
A
----
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
---
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
----
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
-----
40
PsiBlast_CBE
93.35
37%
-83
- C4 -
1N8F
4
AROG_ECOLI
C:
[46-345]
------------------------------------------------
I
L
K
-
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
DP----
H
M
D
-------
N
---------
S
------
F
Q
INDGLRI
A
R
K
L
L
L
D
-
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
---
F
L
S
-----
V
T
-----
K
W
GHSAI
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
E
------
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
-
V
M
I
D
F
S
H
A
----
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
---
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
LESG
E
P
----
L
----
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
-----
22
PsiBlast_CBE
93.31
35%
-67
- C4 -
4UMC
3
?
C:
[15-336]
---------------
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
Q
E
I
S
D
L
V
H
-
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
L
D
G
T
------
F
D
I
N
F
G
L
R
Q
-------
A
R
S
L
L
L
S
-
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
---
F
L
S
-----
V
T
-----
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
-
I
D
C
S
H
A
----
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
---
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
----
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
-----
103
HHSearch
93.29
33%
-71
* C4 *
3TQK
3
?
A:
[6-341]
--
N
I
K
K
E
K
V
L
I
P
A
E
V
L
I
Q
D
I
P
L
L
K
T
S
F
E
T
V
R
K
S
R
---------
K
E
I
A
N
I
I
H
-
G
N
D
D
R
V
A
V
V
V
G
P
C
S
I
H
D
P
A
A
A
I
E
Y
A
T
K
L
K
E
Q
V
K
K
F
H
K
D
I
L
I
I
M
R
V
Y
F
E
K
P
-
R
T
T
-
I
G
W
K
G
F
I
N
------
D
P
D
-------
L
D
N
S
YN
I
N
K
G
L
------
R
L
-------
A
R
N
L
L
S
D
L
T
-
N
M
G
L
P
C
A
T
E
F
L
D
V
I
T
P
Q
Y
F
A
E
L
I
T
W
G
A
I
G
A
R
T
V
E
S
Q
V
H
R
E
L
A
S
G
L
S
A
S
I
G
F
K
N
A
T
N
G
D
V
Q
V
A
V
D
A
V
K
S
A
T
Y
P
H
H
F
L
S
T
T
K
-----
S
G
S
T
---
A
I
-----
F
A
T
K
G
N
Q
N
G
H
V
I
L
R
G
G
A
-----
S
G
P
N
F
S
K
E
H
V
D
D
C
I
A
K
L
K
K
A
D
-
I
N
T
K
V
M
I
D
C
S
H
G
----
N
S
Q
K
D
H
S
K
Q
I
S
V
L
A
D
I
C
E
Q
I
K
H
----
S
N
D
I
F
G
V
M
I
E
S
N
L
V
A
G
N
Q
D
----
I
N
KKP-
L
----
T
Y
G
Q
S
V
T
D
K
C
V
D
F
E
E
T
V
K
M
L
E
M
L
A
E
A
V
-----
24
PsiBlast_CBE
93.17
35%
-67
- C4 -
4UMB
3
?
D:
[17-336]
-----------------
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
ASGLVHRTR
Q
E
I
S
D
L
V
H
-
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
H
-------
L
D
G
T
------
F
DINFGL
R
Q
-------
A
R
S
L
L
L
S
-
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
---
F
L
S
-----
V
T
-----
K
A
GHSAI
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
E
------
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
-
I
D
C
S
H
A
----
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
---
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
----
K
P
----
E
----
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
-----
11
PsiBlast_PDB
93.17
35%
-75
- C4 -
3TQK
3
?
A:
[14-330]
----------
I
P
A
E
V
L
I
Q
D
I
P
L
-
L
K
T
S
F
E
T
V
R
K
S
R
--------
K
E
I
A
N
I
I
H
-
G
N
D
D
R
V
A
V
V
V
G
P
C
S
I
H
D
P
A
A
A
I
E
Y
A
T
K
L
K
E
Q
V
K
K
F
H
K
D
I
L
I
I
M
R
V
Y
F
E
K
P
-
R
T
T
-
I
G
W
K
G
F
I
N
------
D
P
D
LDNSYN
I
N
K
G
L
------
R
------
L
--------
A
R
N
L
L
S
D
L
T
N
-
M
G
L
P
C
A
T
E
F
L
D
V
I
T
P
Q
Y
F
A
E
L
I
T
W
G
A
I
G
A
R
T
V
E
S
Q
V
H
R
E
L
A
S
G
L
S
A
S
I
G
F
K
N
A
T
N
G
D
V
Q
V
A
V
D
A
V
K
S
A
T
Y
P
H
H
---
F
L
S
-----
T
T
-----
K
S
G
S
T
A
I
F
A
T
K
G
N
Q
N
G
H
V
I
L
R
G
-----
G
A
S
G
P
N
F
S
K
E
H
V
D
D
C
I
A
K
L
K
K
A
D
I
-
N
T
K
V
M
I
D
C
S
H
G
----
N
S
Q
K
D
H
S
K
Q
I
----
S
V
L
A
D
I
C
E
Q
I
K
H
S
N
D
I
F
G
V
M
I
E
S
N
L
V
A
G
N
Q
D
INK-
K
P
----
L
----
T
Y
G
Q
S
V
T
D
K
C
V
D
F
E
E
T
V
K
M
L
E
M
L
A
E
A
V
-----
102
HHSearch
90.61
33%
-64
- C4 -
1OF8
5
AROG_YEAST
A:
[23-361]
-
V
R
I
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
R
---------
R
E
A
I
D
I
I
T
-
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
-
R
T
T
V
-
G
W
K
G
L
I
N
------
D
P
D
-------
V
N
N
T
FN
I
N
K
G
L
------
Q
S
-------
A
R
Q
L
F
V
N
L
-
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
G
V
T
K
-----
H
G
V
A
---
A
I
-----
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
G
K
-----
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
L
P
A
-
G
--
S
N
G
L
M
I
D
Y
S
H
G
----
N
S
N
K
D
F
R
N
Q
P
K
V
N
D
V
V
C
E
Q
I
A
N
---
G
E
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
----
I
-----
L
----
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
-----
15
PsiBlast_PDB
89.21
31%
-52
- C4 -
1OFA
4
AROG_YEAST
A:
[26-361]
-
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
---
R
---------
R
E
A
I
D
I
I
T
-
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
D
-------
V
N
N
T
------
F
N
I
N
K
G
-
L
Q
-------
S
A
R
Q
L
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
---
F
M
G
-----
V
T
-----
K
H
GVA
A
I
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
G
K
K
G
T
-----
N
Y
D
A
K
S
V
A
E
A
---
K
A
Q
L
P
A
G
S
N
G
L
M
I
D
Y
S
H
G
----
N
S
N
K
D
F
R
N
Q
P
K
-
V
N
D
V
V
C
E
Q
I
A
N
G
E
--
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
----
I
P
-----AGL-
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
-----
14
PsiBlast_PDB
88.40
31%
-51
- C4 -
1OF8
5
AROG_YEAST
A:
[26-361]
-
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
---
R
---------
R
E
A
I
D
I
I
T
-
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
D
-------
V
N
N
T
------
F
N
I
N
K
G
-
L
Q
-------
S
A
R
Q
L
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
---
F
M
G
-----
V
T
-----
K
H
G
V
A
A
I
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
G
K
K
G
T
-----
N
Y
D
A
K
S
V
A
E
A
---
K
A
Q
L
P
A
G
S
N
G
L
M
I
D
Y
S
H
G
----
N
S
N
K
D
F
R
N
Q
P
K
-
V
N
D
V
V
C
E
Q
I
A
N
G
E
--
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
----
I
------L---
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
-----
13
PsiBlast_PDB
88.12
31%
-51
- C4 -
1OAB
2
AROG_YEAST
A:
[26-361]
-
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
---
R
---------
R
E
A
I
D
I
I
T
-
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
D
-------
V
N
N
T
------
F
N
I
N
K
G
-
L
Q
-------
S
A
R
Q
L
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
---
F
M
G
-----
V
T
-----
K
H
G
V
A
A
I
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
G
K
K
G
T
-----
N
Y
D
A
K
S
V
A
E
A
---
K
A
Q
L
P
A
G
S
N
G
L
M
I
D
Y
S
H
G
----
N
S
N
K
D
F
R
N
Q
P
K
-
V
N
D
V
V
C
E
Q
I
A
N
G
E
--
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
----
I
P
-----AGL-
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
-----
64
PsiBlast_CBE
87.70
31%
-51
- C4 -
1OF8
5
AROG_YEAST
B:
[26-361]
-
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
---
R
---------
R
E
A
I
D
I
I
T
-
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
D
-------
V
N
N
T
------
F
NINKG-
L
Q
-------
S
A
R
Q
L
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
---
F
M
G
-----
V
T
-----
K
H
GVAAI
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
G
K
K
G
T
-----
N
Y
D
A
K
S
V
A
E
A
---
K
A
Q
L
P
A
G
S
N
G
L
M
I
D
Y
S
H
G
----
N
S
N
K
D
F
R
N
Q
P
K
-
V
N
D
V
V
C
E
Q
I
A
N
G
E
--
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
----
I
P
-----KAGL
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
-----
63
PsiBlast_CBE
87.64
31%
-55
- C4 -
1OFA
5
AROG_YEAST
B:
[26-361]
-
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
---
R
---------
R
E
A
I
D
I
I
T
-
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
D
-------
V
N
N
T
------
F
NINKG-
L
Q
-------
S
A
R
Q
L
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
---
F
M
G
-----
V
T
-----
K
H
GVAAI
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
G
K
K
G
T
-----
N
Y
D
A
K
S
V
A
E
A
---
K
A
Q
L
P
A
G
S
N
G
L
M
I
D
Y
S
H
G
----
N
S
N
K
D
F
R
N
Q
P
K
-
V
N
D
V
V
C
E
Q
I
A
N
G
E
--
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
---------------
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
-----
17
PsiBlast_PDB
86.16
31%
-53
- C4 -
1OFO
1
AROG_YEAST
A:
[26-361]
-
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
---
R
---------
R
E
A
I
D
I
I
T
-
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
-
R
T
T
-
V
G
W
K
G
L
I
N
------
D
P
D
-------
V
N
N
T
------
F
N
I
N
K
G
-
L
Q
-------
S
A
R
Q
L
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
---
F
M
G
-----
V
T
-----
K
H
G
V
A
A
I
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
G
K
K
G
T
-----
N
Y
D
A
K
S
V
A
E
A
---
K
A
Q
L
P
A
G
S
N
G
L
M
I
D
Y
S
H
G
----
N
S
N
K
D
F
R
N
Q
P
K
-
V
N
D
V
V
C
E
Q
I
A
N
G
E
--
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
----
I
P
-----AGL-
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
-----