@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1742: (2015-12-10 )
MIELKGVNFKYKNTKNSCLDNIDLEIKKGEFVLISGASGSGKTSITRVINKLIPYYYEGELEGTVKINNDLVSSYQMFELSEIVGSVFQNPRTQFFNVDTNSEIVFGLENQGVSRDILKKRLKETCETLDINKLQNRNIFHLSGGEKQKIAFASVYAMNPDIYLLDEPSSNLDIPTIEVLKRHLSVLKNSGKTVIISEHRIYYLMDLVDKVIYMKNGQIQKSYSKEDFLNLSEDEIKAMALRCRKKTKLNIEMSNNEKHPYLQVNDFSIYRKDNCIINNMNFSANKGDIVAVIGSNGVGKTTFLRTLCGLHDNYKGDVLLNSKKTDAKKRRQKNYMVMQDVNYQLFAESVFAECKLGIENVSDDLIEEILNEFDLSDYKNNHPNTLSGGQKQRLAIAVGLICKKEIFVLDEPTSGLDYTNMVKTVELLKRYSKDKIIFIATHDTEFANLICNRVLDLEK
Atome Classification :
(36 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10...-----..--...20.....-...30........40........-50......--..--60......--.-----------.70----------.-------......------..80.--..----.--...--..90-----....-----....100.......110.......120---.........130.-...--...140---.----........150.......160.......170..-.....180.....-..190.......200---.......210....---.----------------..220-----....-------...230-----------...---...--...------240.......250-------.----.--..-----.....260.----------.----.....270.--......280.......290.-......300.......310.......-----320---..---..------.----..-----------..330-.......340.-------------------------------------------...---..-.350...----------------------------------------...-.--360.--------------......----..370......--.380.......390.......400.......410.......420.......430--.--..--.-...440.......450.......-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
E
LKG
V
N
F
K
YKNT-----KN--SCLDNI
D
L
E
I
-KKG
E
F
V
L
I
SGASGSG
K
T
S
I
T
R
V
I
-
N
K
LI
P
Y
Y
Y--EG--EL
E
G
T
V
K
I--
N
-----------
N
D
-----------
L
-------
V
S
S
Y
Q
M
------
F
E
L
-
S
--
E
I
----
V
--
G
S
V
--
F
QNP-----R
T
Q
F
-----
F
N
VDTNS
E
I
V
F
G
LENQGV
S
R
D
I
L
K
K
-----
R
L
K
E
T
C
E
TLDINK-LQN--R
N
I
F
-----
H
----LSGGE
K
Q
K
I
A
F
A
S
V
Y
A
MNP
D
I
Y
L
LDEPSSNLDI-
P
T
I
E
V
L
K
R
H
L
S
V
L
-KNSG
K
T
V
I
ISEHR
I
Y
---
Y
L
M
D
L
V
D
K
V
I
YMKN---G----------------
Q
I
Q
KS-----YSKE-------DFLN-------------L
S
E
---
D
E
I
--
K
A
M
------
A
L
R
CRK
K
T
K
L
N
---------
I
----
E
--MS-----NNEKHP
Y
L
Q
----------V----N
D
F
S
I
Y
RKD--
N
C
I
I
NNMNFSANKG
D
I
V
A
V
I-GSNGV
G
K
T
T
F
L
R
T
L
C
GLHDNYKG
D
V
L
-----
L
-----NS---KK------T----
D
A
-----------
K
K
R
R
Q-KN
Y
M
V
M
QDV
N
Y
-------------------------------------------
Q
L
F
---
A
E
-
S
V
F
A
E
C
K----------------------------------------LGI-E--N--V--------------
S
D
D
L
I
E
----
E
I
L
N
EFDLSDY--KNNHPNTLSGGQ
K
Q
R
L
A
I
A
V
G
L
I
CK
K
E
I
F
V
L
DEPTSGL
D
Y
T
N
M
V
K
T
V
E
L
L
K
R
YS--K--D
K
--
I
-
I
F
I
ATHD
T
E
F
A
N
L
I
C
N
R
V
LDLEK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Fugue
67.12
23%
-62
- C2 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
QE
I
S
W
F
D
T
N
HSGT
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
GD
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
NG
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
GSLN
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
LDRKPVIDSS
S
K
A
G
R
KDMKIK
G
D
I
T
V
E
N
V
H
F
T
Y
P
S
R
-----
P
D
V-
P
I
L
R
G
M
N
L
R
V
-
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
----
L
R
Y
Y
----
D
--
V
L
K
G
K
I
T
I
--
D
-----------
G
V
-----------
D
-------
V
R
D
I
N
L
------
E
F
L
-
R
--
K
N
----
V
--
A
V
V
--
S
Q
E
P
-------
A
L
-----
F
N
C
T
I
E
E
N
I
S
L
G
--
K
E
G
I
T
R
E
E
M
V
A
-----
A
C
K
M
A
N
A
E
K
F
I
K
T
-
L
P
N
GY
N
T
L
V
GDR
G
T
Q
----
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
-
E
S
E
G
I
V
Q
Q
A
L
D
K
A
-
A
K
-
G
R
T
T
I
I
I
A
H
R
L
S
---
T
I
R
N
-
A
D
L
I
I
S
C
K
N
---
G
----------------
Q
V
V
E
V
-----
G
D
H
R
-------
A
L
M
A
Q
QG----------
L
Y
Y
---
D
L
V
--
T
A
Q
------
T
F
T
D
A
V
D
S
A
A
E
---------
G
----
E
--
R
I
-----
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQK
T
----
N
L
F
E
I
L
Y
H
A
--
R
P
H
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
A
G
N
P
A
D
F
L
S
Q
G
H
-----
F
-----
W
A
---
L
M
------
F
----
L
V
-----------
L
A
A
A
Q
-
G
I
C
S
F
L
M
T
F
F
M
-------------------------------------------
G
I
A
---
S
E
-
S
L
T
R
D
L
R
--------------------------------------------
N
--
K
--
L
--------------
F
R
N
V
L
S
----
Q
H
I
G
F
F
D
---------
S
P
Q
N
A
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
-----------
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
--
G
--
I
G
--
L
-
A
F
F
Y
--
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
4
PsiBlast_PDB
66.42
25%
-71
- C3 -
3OZX
5
?
A:
[30-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
G
E
I
I
P
N
F
----
G
--
D
P
N
S
K
V
G
---
K
-----------
D
E
-----------
V
-------
L
K
R
F
R
G
------
K
E
I
-
Y
--
N
Y
----
F
--
K
E
L
--
Y
S
N
E
L
K
I
V
H
K
I
Q
Y
-------
V
E
Y
A
S
K
F
L
K
G
T
V
N
E
I
L
T
K
I
D
E
R
G
-----
K
K
D
E
V
K
E
L
L
N
M
T
N
-
L
W
N
--
K
D
A
N
-----
I
----
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
R
E
R
M
N
M
A
K
A
I
R
E
L
L
-
K
N
--
K
Y
V
I
V
V
D
H
D
L
I
V
L
D
Y
L
T
D
L
I
-
H
I
I
Y
G
E
S
SV
Y
G
----------------
R
V
S
K
S
-----
Y
A
A
R
-------
V
G
I
N
N
F
L
K
GYLPAENMK
I
R
P
---
D
E
I
--
K
F
M
---------
L
K
------------------------------
L
K
T
K
M
K
W
T
K
----------
I
I
K
K
L
G
D
F
Q
L
--------
V
V
D
N
G
--
E
A
K
E
G
E
I
I
G
I
L
-
G
P
N
G
I
G
K
T
T
F
A
R
I
L
V
G
E
I
T
A
D
E
G
S
V
T
-----
P
-----
E
K
---
Q
I
------
L
----
S
Y
-----------
K
P
Q
R
I
F
P
N
Y
----
D
G
T
V
-------------------------------------------
Q
Q
Y
---
L
E
-
N
A
S
K
D
A
L
-----------------------------------------------
S
--
T
--------------
S
S
W
F
F
E
----
E
V
T
K
R
L
N
L
H
R
L
--
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
T
--
R
--
E
R
K
A
V
-
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
V
F
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
63.71
25%
-63
- C3 -
3BK7
2
?
A:
[114-546]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
C
--
E
D
ND
S
W
D
N
V
I
R
A
F
R
G
-----------
N
E
-----------
L
-------
Q
N
Y
F
E
R
------
L
K
N
-
G
--
E
I
--------------
R
P
-----
V
V
K
P
-----
Q
Y
V
D
L
L
P
K
A
V
-----
K
G
K
V
R
E
L
L
K
K
V
DEVG
K
F
E
E
V
V
K
E
L
E
L
E
N
-
V
L
D
--
R
E
L
H
-----
Q
----
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
-
R
Q
R
L
K
V
A
R
V
I
R
R
L
-
A
N
E
G
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
-
H
V
V
Y
G
E
P
---
G
V
Y
G
I
F
S
K
PKG
T
R
N
G
I
N
E
F
L
Q
G
-----
Y
L
K
D
-------
E
N
V
R
-------------
F
R
P
---
Y
E
I
--
R
F
T
------
K
L
----
S
E
R
V
D
---------
V
----
E
--
R
E
-----
T
L
V
E
Y
P
R
L
-----------
V
----
K
D
Y
G
S
F
K
-------
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
-
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
E
-----
W
-----
D
L
---
T
V
------
A
----
Y
K
-----------
P
Q
Y
I
K
-
A
E
Y
---
E
G
T
V
Y
-------------------------------------------
E
L
L
------
S
K
I
D
S
S
K
----------------------------------------
L
N
-----------------------
S
N
F
Y
K
T
----
E
L
L
K
P
L
G
I
I
D
L
--
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
--
E
K
N
E
K
--
T
-
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
61.48
22%
-72
* C3 *
1YQT
4
?
A:
[25-476]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
C
V
H
R
Y
G
V
------
N
A
--
F
V
L
Y
R
L
P
-
V
V
-
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
-
A
G
Q
L
I
P
N
L
-------
C
G
D
N
D
S
W
--
D
-----------
G
V
-----------
I
R
A
F
RGNE
L
Q
N
Y
F
-------
E
K
L
-
K
N
-
G
E
----
I
R
P
V
V
K
--
P
Q
Y
V
-------
D
L
-----
I
P
K
A
V
K
G
K
V
I
E
L
L
K
-----
K
A
D
E
T
G
-----
K
L
E
E
V
V
K
A
L
E
L
E
N
-
V
L
E
--
R
E
I
Q
-----
H
----
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
-
R
Q
R
L
N
A
A
R
A
I
R
R
L
-
S
E
E
G
K
S
V
L
V
V
E
H
D
L
A
---
V
L
D
Y
L
S
D
I
I
H
V
V
Y
G
---
E
----------------
P
G
-
V
Y
-----
G
I
F
S
-------
Q
P
K
G
-------------
T
R
N
G
I
N
E
F
L
--
R
G
Y
LKDENV
R
F
R
P
Y
E
I
-
K
F
T
---------
K
TG--
E
--
R
V
-----
E
I
E
R
E
T
L
V
T
----------
Y
----
P
R
L
V
K
D
Y
G
S
---
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
-
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
I
E
-----
W
-----
D
L
-----------------------------------
T
V
A
Y
K
P
Q
Y
I
K
--------------------------------------------
A
D
Y
---
E
G
-
T
V
Y
E
L
L
S
----------------------------------------
K
I
D
-
A
--
S
--
K
L
N
------------
S
N
F
Y
K
T
----
E
L
L
K
P
L
G
I
I
D
L
--
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
--
E
K
--
T
-
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
HHSearch
61.25
21%
-68
- C3 -
3BK7
4
?
A:
[84-546]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
V
N
L
P
E
Q
L
D
E
D
CVHRY
G
V
--
N
A
F
V
L
Y
R
L
P
I
V
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
-
A
G
Q
L
I
P
N
L
--
C
-----
E
D
N
D
S
W
--
D
N
V
I
R
A
F
R----
G
N
-----------
E
-------
L
Q
N
Y
F
-------
E
R
L
K
N
GE
I
R
----
P
--
V
V
K
--
P
Q
Y
V
-------
D
L
-----
L
P
K
A
V
K
G
K
V
R
E
L
L
K
-----
K
V
D
E
V
G
-----
K
F
E
E
V
V
K
E
L
E
L
E
N
-
V
L
D
--
R
E
L
H
-----
Q
----
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
-
R
Q
R
L
K
V
A
R
V
I
R
R
L
-
A
N
E
G
K
A
V
L
V
V
E
H
D
L
A
---
V
L
D
Y
L
S
D
V
I
H
V
V
Y
G
---
E
----------------
P
G
V
Y
------
G
I
F
S
K
PKG
T
R
N
G
I
N
E
-------------
F
L
Q
---
G
Y
L
KD
E
N
V
------
R
F
R
P
Y
E
I
-
R
F
T
---------
K
----
L
SE
R
V
-----
D
V
E
R
E
T
L
V
E
----------
Y
----
P
R
L
V
K
D
Y
G
S
---
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
-
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
E
-----
W
-----
D
L
-----------------------------------
T
V
A
Y
K
P
Q
Y
I
K
--------------------------------------------
A
E
Y
---
E
G
-
T
V
Y
E
L
L
S
----------------------------------------
K
I
D
-
S
--
S
--
K
L
N
------------
S
N
F
Y
K
T
----
E
L
L
K
P
L
G
I
I
D
L
--
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
--
E
K
--
T
-
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
61.01
24%
-58
- C3 -
1YQT
4
?
A:
[44-476]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
C
GD
N
D
--
S
W
D
G
V
I
R
A
F
R
G
-----------
N
E
-----------
L
-------
Q
N
Y
F
E
K
------
L
K
N
-
G
--
E
I
--------------
R
P
-----
V
V
K
P
-----
Q
Y
V
D
L
I
P
K
A
V
-----
K
G
K
V
I
E
L
L
K
K
A
DETG
K
L
E
E
V
V
K
A
L
E
L
E
N
-
V
L
E
--
R
E
I
Q
-----
H
----
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
-
R
Q
R
L
N
A
A
R
A
I
R
R
L
-
S
E
E
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
-
H
V
V
Y
G
E
P
---
G
V
Y
G
I
F
S
QPKG
T
R
N
G
I
N
E
F
L
R
G
-----
Y
L
K
D
-------
E
N
V
R
-------------
F
R
P
---
Y
E
I
--
K
F
----------
T
K
T
G
E
R
V
E
---------
I
----
E
--
R
E
-----
T
L
V
T
Y
P
R
L
-----------
V
----
K
D
Y
G
S
F
R
-------
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
-
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
I
E
-----
W
-----
D
L
---
T
V
------
A
----
Y
K
-----------
P
Q
Y
I
K
-
A
D
Y
---
E
G
T
V
Y
-------------------------------------------
E
L
L
---
S
--------
K
----------------------------------------
I
D
A
-
S
--
K
--
L
--------------
N
S
N
F
Y
K
T
---
E
L
L
K
P
L
G
I
I
D
L
--
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
--
E
K
N
E
K
--
T
-
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
59.13
22%
-74
- C3 -
3OZX
5
?
A:
[5-460]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
H
R
Y
K
V
------
N
G
--
F
K
L
F
G
L
P
T
-
P
-
K
N
N
T
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
-
A
G
E
I
I
P
N
---------
F
G
D
P
N
S
--
K
VG
K
D
E
V
L
K
R
F
R
G
K
-----------
E
-------
I
Y
N
Y
F
K
E
L
Y
S
NE
L
K
I
-
V
--
H
K
----
I
--
Q
Y
V
--
E
Y
A
S
-------
K
F
-----
L
K
G
T
V
N
E
I
L
T
K
I
---------
D
E
R
G
-----
K
K
D
E
V
K
E
L
L
N
M
T
N
-
L
W
N
--
K
D
A
N
-----
I
----
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
-
R
E
R
M
N
M
A
K
A
I
R
E
L
-
L
K
-
N
K
Y
V
I
V
V
D
H
D
L
I
---
V
L
D
Y
L
T
D
L
I
H
I
I
Y
----
G
----------------
E
S
S
V
Y
-----
G
R
V
S
-------
K
S
Y
A
-------------
A
R
V
---
G
I
N
--
N
F
L
K
-----
G
Y
L
P
A
E
N
M
K
I
R
PDEIKFMLK------------------
L
K
T
K
M
K
----------
W
----
T
K
I
I
K
K
L
G
D
---
F
Q
L
V
V
D
N
G
E
A
K
E
G
E
I
I
G
I
L
-
G
P
N
G
I
G
K
T
T
F
A
R
I
L
V
G
E
I
T
A
D
E
G
S
V
T
-----
P
-----
E
K
---
Q
-------------------------------
I
L
S
Y
K
P
Q
R
I
F
--------------------------------------------
P
N
Y
---
D
G
-
T
V
Q
Q
Y
L
E
----------------------------------------
N
A
S
-
K
--
D
--
A
LST-----------
S
S
W
F
F
E
----
E
V
T
K
R
L
N
L
H
R
L
--
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
T
R
E
R
--
K
A
--
V
-
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
V
F
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
59.13
32%
-106
- C2 -
4YMU
2
?
A:
[16-207]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
-
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
-----
I
DGVKI
N
N
---
G
K
------
V
----
N
I
-----------
N
K
V
R
Q
-
K
V
G
M
V
F
Q
--
H
F
-------------------------------------------
N
L
F
---
P
H
-
L
T
----------------------------------------------
A
I
-
E
--
N
--
I
T
LAPVKVKKMN
K
K
E
A
E
E
L
A
V
----
D
L
L
A
K
V
G
L
L
D
K
--
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
58.82
31%
-105
- C2 -
3TUZ
1
METN_ECOLI
G:
[44-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
-
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
-----
V
-----
D
G
---
Q
E
LTTLSE
S
----
E
L
-----------
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
--------------------------------------------
L
S
---
S
R
-
T
V
F
G
N
V
A
----------------------------------------
L
P
L
-
E
LD
N
--
T
--------------
P
K
D
E
V
K
RRVT
E
L
L
S
L
V
G
L
G
D
K
--
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
--
R
RL
G
L
--
T
-
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
58.40
25%
-53
- C3 -
3J15
2
?
B:
[100-532]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
C
--
E
D
ND
S
W
D
N
V
I
R
A
F
R
G
-----------
N
E
-----------
L
-------
Q
N
Y
F
E
R
------
L
K
N
-
G
--
E
I
--------------
R
P
-----
V
V
K
P
-----
Q
Y
V
D
L
L
P
K
A
V
-----
K
G
K
V
R
E
L
L
K
K
V
DEVG
K
F
E
E
V
V
K
E
L
E
L
E
N
-
V
L
D
--
R
E
L
H
-----
Q
----
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
-
R
Q
R
L
K
V
A
R
V
I
R
R
L
-
A
N
E
G
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
-
H
V
V
Y
G
E
P
---
G
V
Y
G
I
F
S
K
PKG
T
R
N
G
I
N
E
F
L
Q
G
-----
Y
L
K
D
-------
E
N
V
R
-------------
F
R
P
---
Y
E
I
--
R
F
T
------
K
L
----
S
E
R
V
D
---------
V
----
E
--
R
E
-----
T
L
V
E
Y
P
R
L
-----------
V
----
K
D
Y
G
S
F
K
-------
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
-
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
E
-----
W
-----
D
L
---
T
V
------
A
----
Y
K
-----------
P
Q
Y
I
K
-
A
E
Y
---
E
G
T
V
Y
-------------------------------------------
E
L
L
------
S
K
I
D
S
S
K
----------------------------------------
L
N
-----------------------
S
N
F
Y
K
T
----
E
L
L
K
P
L
G
I
I
D
L
--
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
--
E
K
N
E
K
--
T
-
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
58.30
23%
-62
- C1 -
2IW3
7
EF3A_YEAST
A:
[436-973]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
N
C
E
F
S
L
A
Y
G
-----
A
K
--
I
L
L
N
K
T
Q
L
R
L
-
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
-
A
N
G
Q
V
-----------
D
G
F
------------------------------
P
-------
T
Q
------------
E
-
E
--
C
R
----
T
--
V
Y
V
--
E
H
D
I
-----
D
G
T
H
-----
S
D
T
S
V
L
D
F
V
F
E
S
G
V
----
G
---
T
K
E
-----
A
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
--
M
P
I
S
-----
A
----
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
-
V
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
T
S
I
T
I
S
H
D
S
V
---
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
---
L
----------------
K
L
R
K
Y
K
----
G
N
F
T
-------
E
F
V
K
-------------
K
C
P
---
A
A
K
AY
E
E
L
------
S
N
T
D
L
E
F
-
K
F
P
---------
E
PGYL
E
--
G
V
-----
K
T
K
Q
K
A
I
V
K
----------
V
----
T
N
M
E
F
Q
Y
P
G
TS
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
-
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
Y
-----
T
-----
H
E
---
N
C
------
R
I
A
Y
I
K
Q
H
A
F
A
H
IESHLD
K
T
P
S
E
-
Y
I
Q
W
R
F
Q
T
G
E
D
RETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
-
L
L
G
E
N
I
G
MKS
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
G
Q
F
R
--
P
--
L
--------------
T
R
K
E
I
E
----
E
H
C
S
M
L
G
L
D
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
------
E
G
--
G
-
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
58.28
32%
-106
- C2 -
4YMW
-
?
J:
[16-207]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
-
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
-----
I
DGVKI
N
N
---
G
K
------
V
----
N
I
-----------
N
K
V
R
Q
-
K
V
G
M
V
F
Q
--
H
F
-------------------------------------------
N
L
F
---
P
H
-
L
T
----------------------------------------------
A
I
-
E
--
N
--
I
TLAPVKVKKMNKKE
A
E
E
L
A
V
----
D
L
L
A
K
V
G
L
L
D
K
--
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.97
32%
-107
- C2 -
4YMS
-
?
J:
[16-207]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
-
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
-----
I
DGVKI
N
N
---
G
K
------
V
----
N
I
-----------
N
K
V
R
Q
-
K
V
G
M
V
F
Q
--
H
F
-------------------------------------------
N
L
F
---
P
H
-
L
T
----------------------------------------------
A
I
-
E
--
N
--
I
TLAPVKVKKMNKKE
A
E
E
L
A
V
----
D
L
L
A
K
V
G
L
L
D
K
--
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
57.49
31%
-106
- C2 -
3TUZ
1
METN_ECOLI
C:
[44-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
-
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
-----
V
-----
D
G
---
Q
E
LTTLSE
S
----
E
L
-----------
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
--------------------------------------------
L
S
---
S
R
-
T
V
F
G
N
V
A
----------------------------------------
L
P
L
-
E
LD
N
--
T
--------------
P
K
D
E
V
K
RRVT
E
L
L
S
L
V
G
L
G
D
K
--
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
--
R
RL
G
L
--
T
-
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
57.38
31%
-108
- C2 -
3TUI
1
METN_ECOLI
H:
[44-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
-
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
-----
V
-----
D
G
---
Q
E
LTTLSE
S
----
E
L
-----------
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
--------------------------------------------
L
S
---
S
R
-
T
V
F
G
N
V
A
----------------------------------------
L
P
L
-
E
LD
N
--
T
--------------
P
K
D
E
V
K
RRVT
E
L
L
S
L
V
G
L
G
D
K
--
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
--
R
RL
G
L
--
T
-
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
57.35
31%
-102
- C2 -
3TUI
1
METN_ECOLI
C:
[44-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
-
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
-----
V
-----
D
G
---
Q
E
LTTLSE
S
----
E
L
-----------
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
--------------------------------------------
L
S
---
S
R
-
T
V
F
G
N
V
A
----------------------------------------
L
P
L
-
E
LD
N
--
T
--------------
P
K
D
E
V
K
RRVT
E
L
L
S
L
V
G
L
G
D
K
--
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
--
R
RL
G
L
--
T
-
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
57.23
32%
-105
- C2 -
4YMU
2
?
J:
[16-207]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
-
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
-----
I
DGVKI
N
N
---
G
K
------
V
----
N
I
-----------
N
K
V
R
Q
-
K
V
G
M
V
F
Q
--
H
F
-------------------------------------------
N
L
F
---
P
H
-
L
T
----------------------------------------------
A
I
-
E
--
N
--
I
TLAPVKVKKMNKKE
A
E
E
L
A
V
----
D
L
L
A
K
V
G
L
L
D
K
--
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
57.05
31%
-106
- C2 -
3TUZ
1
METN_ECOLI
H:
[44-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
-
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
-----
V
-----
D
G
---
Q
E
LTTLSE
S
----
E
L
-----------
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
--------------------------------------------
L
S
---
S
R
-
T
V
F
G
N
V
A
----------------------------------------
L
P
L
-
E
LD
N
--
T
--------------
P
K
D
E
V
K
RRVT
E
L
L
S
L
V
G
L
G
D
K
--
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
--
R
RL
G
L
--
T
-
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
56.65
21%
-63
- C3 -
3J16
2
RLI1_YEAST
B:
[82-542]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
T
H
R
Y
S
A
------
N
S
--
F
K
L
H
R
L
P
-
T
P
-
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
-
A
G
K
Q
K
P
N
---------
L
G
R
F
D
D
--
P
-----------
P
E
W
Q
E
I
I
K
Y
F
RGS
E
-------
L
Q
N
Y
F
T
------
K
M
L
-
E
--
D
D
----
I
--
K
A
I
I
K
P
Q
Y
V
-------
D
N
-----
I
P
R
A
I
K
G
P
V
Q
K
V
G
E
L
L
K
L
R
M
E
K
S
P
E
-----
D
V
K
R
Y
I
K
I
L
Q
L
E
N
-
V
L
K
--
R
D
I
E
-----
K
----
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
-
K
Q
R
L
N
A
A
Q
I
I
R
S
L
-
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
---
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
---
V
----------------
P
S
V
Y
G
V
V
T
LP
A
S
V
R
-------
E
G
I
N
-------------
I
F
L
D
--
G
H
I
PA
E
N
L
------
R
F
R
T
E
A
L
-
Q
F
R
---------
I
----
A
--
D
A
TEDLQ
N
D
S
A
S
R
A
F
S
----------
Y
----
P
S
L
K
K
T
Q
G
---
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
-
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
D
E
G
Q
D
I
-----
P
---------------------------------------
K
L
-
N
V
S
M
K
P
Q
K
I
A
--------------------------------------------
P
K
F
---
P
G
-
T
V
R
Q
L
F
F
----------------------------------------
K
K
I
-
R
--
G
QF
L
--------------
N
P
Q
F
Q
T
----
D
V
V
K
P
L
R
I
D
D
I
--
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
--
K
K
--
T
-
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
56.50
22%
-97
- C2 -
1V43
-
?
A:
[9-218]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
V
E
V
K
----------
L
----
E
N
L
T
K
R
F
G
N
--
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
-
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
-----
F
-----
G
D
---
R
D
------
V
----
T
Y
L----------
P
P
K
D
R
-
N
I
S
M
V
F
Q
-----------------------------------------------------
H
M
-
T
V
Y
E
N
I
A
----------------------------------------
F
P
L
-------
K
KFP
K
D
E
--------
I
D
K
R
V
R
----
W
A
A
E
L
L
Q
I
E
E
L
--
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
--
K
V
--
T
-
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
56.01
32%
-103
- C2 -
4YMV
1
?
A:
[16-207]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
-
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
-----
I
DGVKI
N
N
---
G
K
------
V
----
N
I
-----------
N
K
V
R
Q
-
K
V
G
M
V
F
Q
--
H
F
-------------------------------------------
N
L
F
---
P
H
-
L
T
----------------------------------------------
A
I
-
E
--
N
--
I
T
LAPVKVKKMN
K
K
E
A
E
E
L
A
V
----
D
L
L
A
K
V
G
L
L
D
K
--
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
55.01
32%
-103
- C2 -
4YMV
1
?
J:
[16-207]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
-
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
-----
I
DGVKI
N
N
---
G
K
------
V
----
N
I
-----------
N
K
V
R
Q
-
K
V
G
M
V
F
Q
--
H
F
-------------------------------------------
N
L
F
---
P
H
-
L
T
----------------------------------------------
A
I
-
E
--
N
--
I
TLAPVKVKKMNKKE
A
E
E
L
A
V
----
D
L
L
A
K
V
G
L
L
D
K
--
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
54.55
31%
-109
- C2 -
2OLK
2
?
B:
[39-230]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
-
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
IDGIN
L
-----
K
A
---
K
D
------
T
----
N
L
-----------
N
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-------------------------------------------
N
L
F
---
P
H
M
T
V
L
N
N
I
T
----------------------------------------
L
A
P
-
M
--
K
--
V
RKWPREK-------
A
E
A
K
A
M
----
E
L
L
D
K
V
G
L
K
D
K
--
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
53.74
31%
-113
- C2 -
3C4J
4
?
B:
[39-230]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
-
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
IDGIN
L
-----
K
A
---
K
D
------
T
----
N
L
-----------
N
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-------------------------------------------
N
L
F
---
P
H
M
T
V
L
N
N
I
T
----------------------------------------
L
A
P
-
M
--
K
--
V
RKWPREK-------
A
E
A
K
A
M
----
E
L
L
D
K
V
G
L
K
D
K
--
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
53.25
31%
-111
- C2 -
2OLK
1
?
D:
[39-230]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
-
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
IDGIN
L
-----
K
A
---
K
D
------
T
----
N
L
-----------
N
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-------------------------------------------
N
L
F
---
P
H
M
T
V
L
N
N
I
T
----------------------------------------
L
A
P
-
M
--
K
--
V
RKWPREK-------
A
E
A
K
A
M
----
E
L
L
D
K
V
G
L
K
D
K
--
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
52.93
31%
-112
- C2 -
2OLJ
4
?
A:
[39-230]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
-
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
DGIN
L
-----
K
A
---
K
D
------
T
----
N
L
-----------
N
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-------------------------------------------
N
L
F
---
P
H
M
T
V
L
N
N
I
T
----------------------------------------
L
A
P
-
M
--
K
--
V
RKWP
R
E
K
-------
A
E
A
K
A
M
----
E
L
L
D
K
V
G
L
K
D
K
--
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
52.07
31%
-108
- C2 -
2Q0H
4
?
A:
[39-230]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
-
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
DGIN
L
-----
K
A
---
K
D
------
T
----
N
L
-----------
N
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-------------------------------------------
N
L
F
---
P
H
M
T
V
L
N
N
I
T
----------------------------------------
L
A
P
-
M
--
K
--
V
RKWP
R
E
K
-------
A
E
A
K
A
M
----
E
L
L
D
K
V
G
L
K
D
K
--
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
51.66
31%
-104
- C2 -
3C41
3
?
K:
[18-209]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
-
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
IDGIN
L
-----
K
A
---
K
D
------
T
----
N
L
-----------
N
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-------------------------------------------
N
L
F
---
P
H
M
T
V
L
N
N
I
T
----------------------------------------
L
A
P
-
M
--
K
--
V
RKWPREK-------
A
E
A
K
A
M
----
E
L
L
D
K
V
G
L
K
D
K
--
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
51.45
31%
-104
- C2 -
3C4J
3
?
A:
[39-230]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
-
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
DGIN
L
-----
K
A
---
K
D
------
T
----
N
L
-----------
N
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-------------------------------------------
N
L
F
---
P
H
M
T
V
L
N
N
I
T
----------------------------------------
L
A
P
-
M
--
K
--
V
RKWP
R
E
K
-------
A
E
A
K
A
M
----
E
L
L
D
K
V
G
L
K
D
K
--
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
51.27
31%
-110
- C2 -
2OLK
1
?
C:
[39-230]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
-
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
IDGIN
L
-----
K
A
---
K
D
------
T
----
N
L
-----------
N
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-------------------------------------------
N
L
F
---
P
H
M
T
V
L
N
N
I
T
----------------------------------------
L
A
P
-
M
--
K
--
V
RKWPREK-------
A
E
A
K
A
M
----
E
L
L
D
K
V
G
L
K
D
K
--
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
50.87
31%
-109
- C2 -
2OLK
1
?
A:
[39-230]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
-
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
DGIN
L
-----
K
A
---
K
D
------
T
----
N
L
-----------
N
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-------------------------------------------
N
L
F
---
P
H
M
T
V
L
N
N
I
T
----------------------------------------
L
A
P
-
M
--
K
--
V
RKWP
R
E
K
-------
A
E
A
K
A
M
----
E
L
L
D
K
V
G
L
K
D
K
--
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
49.87
31%
-108
- C2 -
2Q0H
4
?
B:
[39-230]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
-
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
DGIN
L
-----
K
A
---
K
D
------
T
----
N
L
-----------
N
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-------------------------------------------
N
L
F
---
P
H
M
T
V
L
N
N
I
T
----------------------------------------
L
A
P
-
M
--
K
--
V
RKWP
R
E
K
-------
A
E
A
K
A
M
----
E
L
L
D
K
V
G
L
K
D
K
--
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
49.76
31%
-106
- C2 -
2OLJ
3
?
B:
[39-230]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
-
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
IDGIN
L
-----
K
A
---
K
D
------
T
----
N
L
-----------
N
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-------------------------------------------
N
L
F
---
P
H
M
T
V
L
N
N
I
T
----------------------------------------
L
A
P
-
M
--
K
--
V
RKWPREK-------
A
E
A
K
A
M
----
E
L
L
D
K
V
G
L
K
D
K
--
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
47.68
31%
-102
- C2 -
3C41
3
?
J:
[18-209]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
-
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
IDGIN
L
-----
K
A
---
K
D
------
T
----
N
L
-----------
N
K
V
R
E
-
E
V
G
M
V
F
Q
--
R
F
-------------------------------------------
N
L
F
---
P
H
M
T
V
L
N
N
I
T
----------------------------------------
L
A
P
-
M
--
K
--
V
RKWPREK-------
A
E
A
K
A
M
----
E
L
L
D
K
V
G
L
K
D
K
--
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
--
N
--
E
G
--
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
41.21
32%
-62
- C2 -
1L2T
4
Y796_METJA
A:
[1-230]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
-----
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
-
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
-
G
C
L
-------
D
K
--
P
T
E
G
E
V
Y
I
--
D
-----------
N
I
-----------
K
-------
T
N
D
L
D
D
------
D
E
L
-
T
--
K
I
R
R
D
K
I
--
G
F
V
--
F
Q
---------
Q
F
NLIPL
L
T
A
L
E
N
V
E
L
P
L
I
F
K
Y
R
G
A
M
S
G
--
E
E
-----
R
R
K
R
A
L
E
C
L
K
M
A
E
-
L
E
E
--
R
F
A
N
-----
H
KPNQ
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
-
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
----
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
---
G
----------------
E
V
E
R
E
-----
E
K
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
9.96
36%
-52
- C2 -
4S0F
2
?
B:
[504-657]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
-
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
-----
I
-----
N
G
HSI
K
N
------
I
----
S
L
-----------
E
L
I
R
K
-
K
I
A
F
V
S
Q
D
V
F
---------------------------------------------
I
F
---
S
G
-
T
V
K
E
N
L
C
----------------------------------------
L
G
N
-
E
--
N
--
V
DMDEIIKAAKMAN-
A
H
D
F
I
E
----
K
L
P
L
K
Y
D
--
T
F
--
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------