@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1804: (2015-12-10 )
MSNINLKPEEVGVYAIGGLGEIGKNTYGIEYQDEIIIVDAGIKFPEDDLLGIDYVIPDYSYIVENIDRIKALVITHGHEDHIGGIPFLLKQANLPIYAGPLALALIKGKLEEHGLLRDATLYEIHANTELTFKNLSVTFFRTTHSIPEPLSIVIHTPQGKVICTGDFKFDFTPVGEPADLHRMAALGEDGVLCLLSDSTNAEVPTFTNSEKIVGQSIMKIIEGIDGRIIFASFASNIFRLQQAAEAAVKTGRKIAVFGRSMEKAIVNGIELGYIKVPKGTFIEPSELKNLHASEVLIMCTGSQGESMAALARIANGTHRQVTLQPGDTVIFSSSPIPGNTTSVNKLINTIQEAGVDVIHGKINNIHTSGHGGQQEQKLMLRLIKPKYFMPVHGEYRMQKVHAGLAVDTGIPKENIFIMENGDVLALTSDSARIAGHFNAQDIYVDGNGIGDIGAAVLRDRHDLSEDGVVLAVATVDFDSKMILAGPDILSRGFIYMRESGDLIRESQHILFNAIRIALKNKDASIQSVNGAIVNALRPFLYEKTEREPIIIPMVLTPDK
Atome Classification :
(20 SA)
.........10........20........30........40.......--------------------.50-------........60.------------..-----.....70........80........-----90--.-----.......100.......110...---------.----------------..---------.-120.......130-.-......140.......150....--.--..160.-......170..-...-.----.180.......190.......200..-..--------..--.210.......220-..---.--....230.......240.......250-------.------.-------......260...-..---..270-.....--------------.---------..-------280------..---.-.....-290.........300.--.......310.......320.......330.......340.-.--.-----....-----------.350...----.....-360-...-.-....370.......380..--.....390-----........400.-...-...410--........420.......430.......440.......450.......460.......470.......480.......490.......--500.......510.......520.......530.......540.......550.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSNINL
K
P
E
E
V
G
V
Y
A
IGGL
G
E
IGKNTYG
I
E
Y
Q
D
E
I
I
I
V
DAGIKFPEDD--------------------L
L
G
-------
I
D
YVIP
D
Y
S
Y
I
------------
V
E
-----
N
I
D
R
I
K
A
L
V
I
THGHEDHIGG
I
P
F
L
L
-----KQ--A-----NL
P
I
YA
G
P
L
A
L
A
L
I
K
G
K
L
E
EHGL---------L----------------RD---------
A
-
T
L
Y
E
I
HAN
T
E
L
T
F
-K-N
L
S
V
T
F
F
RTTHSIPE
P
L
S
I
V
I
HT--P--Q
G
K
V
I
C
-
T
GD
F
K
F
D
F
TPV-GE
P
-
A
----
D
L
H
R
M
A
ALGED
G
V
L
C
L
LSDSTNAEVP-TF--------TN--
S
E
K
I
V
G
Q
S
I
M
K
I
I
E-GI---D--G
R
I
I
F
A
S
F
A
S
N
I
F
R
L
Q
Q
A
A
E
A
A
V
KTG--------
R
------
K
-------
I
A
VFGR
S
M
E
K
A
I
-VN---G
I
E
-
L
-
G
Y
I
KV--------------P---------KG-------TF-------I
E
---
P
-
S
E
L
KN-L--HAS
E
V
L
I
M
C
T-GS--QG
E
S
M
A
A
L
A
R
I
ANGT
H
R
Q
V
T
LQPG
D
T
V
I
F
SSSPIPGN
T
-
T
S
-
V
--
N
-----
K
L
I
N
-----------
T
I
Q
-
E
AG----V
D
V
I
H-GK--IN
N
-
I
-HTSGHGG
Q
Q
E
Q
K
L
M
L
R
LIK--P
K
Y
F
MPV------HG
E
Y
R
M
Q
K
VHAG-
L
A
V-DTGIP---KE
N
I
F
I
MENG
D
V
L
A
LTSDS
A
R
I
A
G
HFN
A
Q
D
I
Y
VDGNGI
G
D
I
G
A
A
V
L
R
DRHDLSED
G
V
V
L
A
V
A
T
VDFDS
K
M
I
LA
G
P
D
I
L
SR
G
F
I
Y
MRES--G
D
L
I
R
E
S
Q
H
I
L
F
N
A
I
R
I
A
LKNKDASIQSV
N
G
A
I
V
N
A
L
R
P
F
L
Y
EKTERE
P
I
I
I
P
M
VLTPDK
1
PsiBlast_PDB
95.75
61%
-122
- C1 -
3ZQ4
4
RNJ1_BACSU
A:
[6-553]
-------
N
D
Q
T
A
V
F
A
L
G
G
L
G
E
I
G
K
N
T
Y
A
V
Q
F
Q
D
E
I
V
L
I
D
A
G
I
K
F
P
E
D
E
--------------------
L
L
G
-------
I
D
Y
V
I
P
D
Y
T
Y
L
------------
V
K
-----
N
E
D
K
I
K
G
L
F
I
T
H
G
H
E
D
H
I
G
G
I
P
Y
L
L
-----
R
Q
--
V
-----
N
I
P
V
Y
G
G
K
L
A
I
G
L
L
R
N
K
L
E
E
H
G
L
---------
L
----------------
R
Q
---------
T
-
K
L
N
I
I
G
E
D
D
I
V
K
F
-
R
-
K
T
A
V
S
F
F
R
T
T
H
S
I
P
D
S
Y
G
I
V
V
K
T
--
P
--
P
G
N
I
V
H
-
T
G
D
F
K
F
D
F
T
P
V
-
G
E
P
-
A
----
N
L
T
K
M
A
E
I
G
K
E
G
V
L
C
L
L
S
D
S
T
N
S
E
N
P
-
E
F
--------
T
M
--
S
E
R
R
V
G
E
S
I
H
D
I
F
R
-
K
V
---
D
--
G
R
I
I
F
A
T
F
A
S
N
I
H
R
L
Q
Q
V
I
E
A
A
V
Q
N
G
--------
R
------
K
-------
V
A
V
F
G
R
S
M
E
S
A
I
-
E
I
---
G
Q
T
-
L
-
G
Y
I
N
C
--------------
P
---------
K
N
-------
T
F
-------
I
E
---
H
-
N
E
I
N
R
-
M
--
P
A
N
K
V
T
I
L
C
T
-
G
S
--
Q
G
E
P
M
A
A
L
S
R
I
A
N
G
T
H
R
Q
I
S
I
N
P
G
D
T
V
V
F
S
S
S
P
I
P
G
N
T
-
I
S
-
V
--
S
-----
R
T
I
N
-----------
Q
L
Y
-
R
A
G
----
A
E
V
I
H
-
G
P
--
L
N
D
-
I
-
H
T
S
G
H
G
G
Q
E
E
Q
K
L
M
L
R
L
I
K
--
P
K
F
F
M
P
I
------
H
G
E
Y
R
M
Q
K
M
H
V
K
-
L
A
T
-
D
C
G
I
P
---
E
E
N
C
F
I
M
D
N
G
E
V
L
A
L
K
G
D
E
A
S
V
A
G
K
I
P
S
G
S
V
Y
I
D
G
S
G
I
G
D
I
G
N
I
V
L
R
D
R
R
I
L
S
E
E
G
L
V
I
V
V
V
S
I
D
M
D
D
F
K
I
S
A
G
P
D
L
I
S
R
G
F
V
Y
M
R
E
S
--
G
D
L
I
N
D
A
Q
E
L
I
S
N
H
L
Q
K
V
M
E
R
K
T
T
Q
W
S
E
I
K
N
E
I
T
D
T
L
A
P
F
L
Y
E
K
T
K
R
R
P
M
I
L
P
I
I
M
E
V
--
21
PsiBlast_CBE
95.35
61%
-123
- C1 -
3ZQ4
4
RNJ1_BACSU
E:
[6-553]
-------
N
D
Q
T
A
V
F
A
L
G
G
L
G
E
I
G
K
N
T
Y
A
V
Q
F
Q
D
E
I
V
L
I
D
A
G
I
K
F
P
E
D
E
--------------------
L
L
G
-------
I
D
Y
V
I
P
D
Y
T
Y
L
------------
V
K
-----
N
E
D
K
I
K
G
L
F
I
T
H
G
H
E
D
H
I
G
G
I
P
Y
L
L
-----
R
Q
--
V
-----
N
I
P
V
Y
G
G
K
L
A
I
G
L
L
R
N
K
L
E
E
H
G
L
---------
L
----------------
R
Q
---------
T
-
K
L
N
I
I
G
E
D
D
I
V
K
F
-
R
-
K
T
A
V
S
F
F
R
T
T
H
S
I
P
D
S
Y
G
I
V
V
K
T
--
P
--
P
G
N
I
V
H
-
T
G
D
F
K
F
D
F
T
P
V
-
G
E
P
-
A
----
N
L
T
K
M
A
E
I
G
K
E
G
V
L
C
L
L
S
D
S
T
N
S
E
N
P
-
E
F
--------
T
M
--
S
E
R
R
V
G
E
S
I
H
D
I
F
R
-
K
V
---
D
--
G
R
I
I
F
A
T
F
A
S
N
I
H
R
L
Q
Q
V
I
E
A
A
V
Q
N
G
--------
R
------
K
-------
V
A
V
F
G
R
S
M
E
S
A
I
-
E
I
---
G
Q
T
-
L
-
G
Y
I
N
C
--------------
P
---------
K
N
-------
T
F
-------
I
E
---
H
-
N
E
I
N
R
-
M
--
P
A
N
K
V
T
I
L
C
T
-
G
S
--
Q
G
E
P
M
A
A
L
S
R
I
A
N
G
T
H
R
Q
I
S
I
N
P
G
D
T
V
V
F
S
S
S
P
I
P
G
N
T
-
I
S
-
V
--
S
-----
R
T
I
N
-----------
Q
L
Y
-
R
A
G
----
A
E
V
I
H
-
G
P
--
L
N
D
-
I
-
H
T
S
G
H
G
G
Q
E
E
Q
K
L
M
L
R
L
I
K
--
P
K
F
F
M
P
I
------
H
G
E
Y
R
M
Q
K
M
H
V
K
-
L
A
T
-
D
C
G
I
P
---
E
E
N
C
F
I
M
D
N
G
E
V
L
A
L
K
G
D
E
A
S
V
A
G
K
I
P
S
G
S
V
Y
I
D
G
S
G
I
G
D
I
G
N
I
V
L
R
D
R
R
I
L
S
E
E
G
L
V
I
V
V
V
S
I
D
M
D
D
F
K
I
S
A
G
P
D
L
I
S
R
G
F
V
--------
D
L
I
N
D
A
Q
E
L
I
S
N
H
L
Q
K
V
M
E
R
K
T
T
Q
W
S
E
I
K
N
E
I
T
D
T
L
A
P
F
L
Y
E
K
T
K
R
R
P
M
I
L
P
I
I
M
E
V
--
23
PsiBlast_CBE
95.13
61%
-124
- C1 -
3ZQ4
4
RNJ1_BACSU
C:
[6-553]
-------
N
D
Q
T
A
V
F
A
L
G
G
L
G
E
I
G
K
N
T
Y
A
V
Q
F
Q
D
E
I
V
L
I
D
A
G
I
K
F
P
E
D
E
--------------------
L
L
G
-------
I
D
Y
V
I
P
D
Y
T
Y
L
------------
V
K
-----
N
E
D
K
I
K
G
L
F
I
T
H
G
H
E
D
H
I
G
G
I
P
Y
L
L
-----
R
Q
--
V
-----
N
I
P
V
Y
G
G
K
L
A
I
G
L
L
R
N
K
L
E
E
H
G
L
---------
L
----------------
R
Q
---------
T
-
K
L
N
I
I
G
E
D
D
I
V
K
F
-
R
-
K
T
A
V
S
F
F
R
T
T
H
S
I
P
D
S
Y
G
I
V
V
K
T
--
P
--
P
G
N
I
V
H
-
T
G
D
F
K
F
D
F
T
P
V
-
G
E
P
-
A
----
N
L
T
K
M
A
E
I
G
K
E
G
V
L
C
L
L
S
D
S
T
N
S
E
N
P
-
E
F
--------
T
M
--
S
E
R
R
V
G
E
S
I
H
D
I
F
R
-
K
V
---
D
--
G
R
I
I
F
A
T
F
A
S
N
I
H
R
L
Q
Q
V
I
E
A
A
V
Q
N
G
--------
R
------
K
-------
V
A
V
F
G
R
S
M
E
S
A
I
-
E
I
---
G
Q
T
-
L
-
G
Y
I
N
C
--------------
P
---------
K
N
-------
T
F
-------
I
E
---
H
-
N
E
I
N
R
-
M
--
P
A
N
K
V
T
I
L
C
T
-
G
S
--
Q
G
E
P
M
A
A
L
S
R
I
A
N
G
T
H
R
Q
I
S
I
N
P
G
D
T
V
V
F
S
S
S
P
I
P
G
N
T
-
I
S
-
V
--
S
-----
R
T
I
N
-----------
Q
L
Y
-
R
A
G
----
A
E
V
I
H
-
G
P
--
L
N
D
-
I
-
H
T
S
G
H
G
G
Q
E
E
Q
K
L
M
L
R
L
I
K
--
P
K
F
F
M
P
I
------
H
G
E
Y
R
M
Q
K
M
H
V
K
-
L
A
T
-
D
C
G
I
P
---
E
E
N
C
F
I
M
D
N
G
E
V
L
A
L
K
G
D
E
A
S
V
A
G
K
I
P
S
G
S
V
Y
I
D
G
S
G
I
G
D
I
G
N
I
V
L
R
D
R
R
I
L
S
E
E
G
L
V
I
V
V
V
S
I
D
M
D
D
F
K
I
S
A
G
P
D
L
I
S
R
G
F
V
----------
I
N
D
A
Q
E
L
I
S
N
H
L
Q
K
V
M
E
R
K
T
T
Q
W
S
E
I
K
N
E
I
T
D
T
L
A
P
F
L
Y
E
K
T
K
R
R
P
M
I
L
P
I
I
M
E
V
--
22
PsiBlast_CBE
95.04
61%
-123
- C1 -
3ZQ4
4
RNJ1_BACSU
D:
[6-553]
-------
N
D
Q
T
A
V
F
A
L
G
G
L
G
E
I
G
K
N
T
Y
A
V
Q
F
Q
D
E
I
V
L
I
D
A
G
I
K
F
P
E
D
E
--------------------
L
L
G
-------
I
D
Y
V
I
P
D
Y
T
Y
L
------------
V
K
-----
N
E
D
K
I
K
G
L
F
I
T
H
G
H
E
D
H
I
G
G
I
P
Y
L
L
-----
R
Q
--
V
-----
N
I
P
V
Y
G
G
K
L
A
I
G
L
L
R
N
K
L
E
E
H
G
L
---------
L
----------------
R
Q
---------
T
-
K
L
N
I
I
G
E
D
D
I
V
K
F
-
R
-
K
T
A
V
S
F
F
R
T
T
H
S
I
P
D
S
Y
G
I
V
V
K
T
--
P
--
P
G
N
I
V
H
-
T
G
D
F
K
F
D
F
T
P
V
-
G
E
P
-
A
----
N
L
T
K
M
A
E
I
G
K
E
G
V
L
C
L
L
S
D
S
T
N
S
E
N
P
-
E
F
--------
T
M
--
S
E
R
R
V
G
E
S
I
H
D
I
F
R
-
K
V
---
D
--
G
R
I
I
F
A
T
F
A
S
N
I
H
R
L
Q
Q
V
I
E
A
A
V
Q
N
G
--------
R
------
K
-------
V
A
V
F
G
R
S
M
E
S
A
I
-
E
I
---
G
Q
T
-
L
-
G
Y
I
N
C
--------------
P
---------
K
N
-------
T
F
-------
I
E
---
H
-
N
E
I
N
R
-
M
--
P
A
N
K
V
T
I
L
C
T
-
G
S
--
Q
G
E
P
M
A
A
L
S
R
I
A
N
G
T
H
R
Q
I
S
I
N
P
G
D
T
V
V
F
S
S
S
P
I
P
G
N
T
-
I
S
-
V
--
S
-----
R
T
I
N
-----------
Q
L
Y
-
R
A
G
----
A
E
V
I
H
-
G
P
--
L
N
D
-
I
-
H
T
S
G
H
G
G
Q
E
E
Q
K
L
M
L
R
L
I
K
--
P
K
F
F
M
P
I
------
H
G
E
Y
R
M
Q
K
M
H
V
K
-
L
A
T
-
D
C
G
I
P
---
E
E
N
C
F
I
M
D
N
G
E
V
L
A
L
K
G
D
E
A
S
V
A
G
K
I
P
S
G
S
V
Y
I
D
G
S
G
I
G
D
I
G
N
I
V
L
R
D
R
R
I
L
S
E
E
G
L
V
I
V
V
V
S
I
D
M
D
D
F
K
I
S
A
G
P
D
L
I
S
R
G
F
V
--------
D
L
I
N
D
A
Q
E
L
I
S
N
H
L
Q
K
V
M
------
W
S
E
I
K
N
E
I
T
D
T
L
A
P
F
L
Y
E
K
T
K
R
R
P
M
I
L
P
I
I
M
E
V
--
2
PsiBlast_PDB
84.65
40%
-108
- C1 -
3T3N
2
RNJ_THET2
A:
[16-561]
--------
D
H
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
E
G
--------------------
M
P
G
-------
V
D
L
L
I
P
R
V
D
Y
L
------------
I
E
-----
H
R
H
K
I
K
A
W
V
L
T
H
G
A
E
D
H
I
G
G
L
P
F
L
L
P
M
I
FG
K
E
--
S
-----
P
V
P
I
Y
G
A
R
L
T
L
G
L
L
R
G
K
L
E
E
F
G
L
---------
R
----------------
P
G
---------
A
F
N
L
K
E
I
S
P
D
D
R
I
Q
V
G
R
-
Y
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
T
I
V
H
-
T
G
D
F
K
L
D
P
T
P
I
D
G
K
V
-
S
----
H
L
A
K
V
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
-
G
Y
--------
T
P
--
S
E
M
E
I
A
K
E
L
D
R
V
I
G
-
R
A
---
P
--
G
R
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
------
K
-------
V
A
M
E
G
R
S
M
L
K
F
S
-
R
I
---
A
L
E
-
L
-
G
Y
L
K
V
------------------------
K
D
-------
R
L
-------
Y
T
---
L
-
E
E
V
K
D
-
L
--
P
D
H
Q
V
L
I
L
A
T
-
G
S
--
Q
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
S
S
P
I
P
G
N
E
-
E
A
-
V
--
N
-----
R
V
I
N
-----------
R
L
Y
-
A
L
G
----
A
Y
V
L
Y
-
P
P
--
T
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
------
H
G
E
V
R
H
Q
M
N
F
K
W
-
L
A
E
-
S
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
L
V
V
I
T
A
L
A
G
E
D
P
V
V
-----
E
V
V
S
R
G
F
V
K
A
G
E
R
----
L
L
G
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
E
K
K
-
P
L
E
R
I
R
D
D
I
Y
Y
P
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
---
3
PsiBlast_PDB
84.20
40%
-109
- C1 -
3T3O
3
RNJ_THET2
A:
[16-561]
--------
D
H
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
E
G
--------------------
M
P
G
-------
V
D
L
L
I
P
R
V
D
Y
L
------------
I
E
-----
H
R
H
K
I
K
A
W
V
L
T
H
G
A
E
D
H
I
G
G
L
P
F
L
L
P
M
I
FG
K
E
--
S
-----
P
V
P
I
Y
G
A
R
L
T
L
G
L
L
R
G
K
L
E
E
F
G
L
---------
R
----------------
P
G
---------
A
F
N
L
K
E
I
S
P
D
D
R
I
Q
V
G
R
-
Y
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
T
I
V
H
-
T
G
D
F
K
L
D
P
T
P
I
D
G
K
V
-
S
----
H
L
A
K
V
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
-
G
Y
--------
T
P
--
S
E
M
E
I
A
K
E
L
D
R
V
I
G
-
R
A
---
P
--
G
R
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
------
K
-------
V
A
M
E
G
R
S
M
L
K
F
S
-
R
I
---
A
L
E
-
L
-
G
Y
L
K
V
------------------------
K
D
-------
R
L
-------
Y
T
---
L
-
E
E
V
K
D
-
L
--
P
D
H
Q
V
L
I
L
A
T
-
G
S
--
Q
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
S
S
P
I
P
G
N
E
-
E
A
-
V
--
N
-----
R
V
I
N
-----------
R
L
Y
-
A
L
G
----
A
Y
V
L
Y
-
P
P
--
T
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
------
H
G
E
V
R
H
Q
M
N
F
K
W
-
L
A
E
-
S
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
L
V
V
I
T
A
L
A
G
E
D
P
V
V
-----
E
V
V
S
R
G
F
V
K
A
G
E
R
----
L
L
G
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
E
K
K
-
P
L
E
R
I
R
D
D
I
Y
Y
P
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
---
5
PsiBlast_PDB
84.15
40%
-104
- C1 -
3BK2
7
RNJ_THET2
A:
[15-560]
--------
D
H
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
E
G
--------------------
M
P
G
-------
V
D
L
L
I
P
R
V
D
Y
L
------------
I
E
-----
H
R
H
K
I
K
A
W
V
L
T
H
G
H
E
D
H
I
G
G
L
P
F
L
L
P
M
I
FG
K
E
--
S
-----
P
V
P
I
Y
G
A
R
L
T
L
G
L
L
R
G
K
L
E
E
F
G
L
---------
R
----------------
P
G
---------
A
F
N
L
K
E
I
S
P
D
D
R
I
Q
V
G
R
-
Y
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
T
I
V
H
-
T
G
D
F
K
L
D
P
T
P
I
D
G
K
V
-
S
----
H
L
A
K
V
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
-
G
Y
--------
T
P
--
S
E
M
E
I
A
K
E
L
D
R
V
I
G
-
R
A
---
P
--
G
R
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
------
K
-------
V
A
M
E
G
R
S
M
L
K
F
S
-
R
I
---
A
L
E
-
L
-
G
Y
L
K
V
------------------------
K
D
-------
R
L
-------
Y
T
---
L
-
E
E
V
K
D
-
L
--
P
D
H
Q
V
L
I
L
A
T
-
G
S
--
Q
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
S
S
P
I
P
G
N
E
-
E
A
-
V
--
N
-----
R
V
I
N
-----------
R
L
Y
-
A
L
G
----
A
Y
V
L
Y
-
P
P
--
T
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
------
H
G
E
V
R
H
Q
M
N
F
K
W
-
L
A
E
-
S
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
L
V
V
I
T
A
L
A
G
E
D
P
V
V
-----
E
V
V
S
R
G
F
V
K
A
G
E
R
L
L
G
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
-----
E
K
K
P
L
E
R
I
R
D
D
I
Y
Y
P
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
G
--
38
HHSearch
84.14
40%
-104
- C1 -
3BK2
7
RNJ_THET2
A:
[14-561]
-------
Q
D
H
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
E
G
--------------------
M
P
G
-------
V
D
L
L
I
P
R
V
D
Y
L
------------
I
E
-----
H
R
H
K
I
K
A
W
V
L
T
H
G
H
E
D
H
I
G
G
L
P
F
L
L
-----
P
M
--
I
FGKES
P
V
P
I
Y
G
A
R
L
T
L
G
L
L
R
G
K
L
E
E
F
G
L
R--------
P
----------------
G
A
---------
F
-
N
L
K
E
I
S
P
D
D
R
I
Q
V
-
G
R
Y
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
T
I
V
H
-
T
G
D
F
K
L
D
P
T
P
I
-
D
G
K
V
S
----
H
L
A
K
V
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
-
G
Y
--------
T
P
--
S
E
M
E
I
A
K
E
L
D
R
V
I
G
-
R
A
---
P
--
G
R
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
------
K
-------
V
A
M
E
G
R
S
M
L
K
F
S
-
R
I
---
A
L
E
-
L
-
G
Y
L
K
V
--------------
K
---------
D
--------
R
L
-------
Y
T
---
L
-
E
E
V
K
D
-
L
--
P
D
H
Q
V
L
I
L
A
T
-
G
S
--
Q
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
S
S
P
I
P
G
N
E
-
E
A
-
V
--
N
-----
R
V
I
N
-----------
R
L
Y
-
A
L
G
----
A
Y
V
L
Y
-
P
P
--
T
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
------
H
G
E
V
R
H
Q
M
N
F
K
W
-
L
A
E
-
S
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
L
V
V
I
T
A
L
A
G
E
D
P
-----
V
V
E
V
V
S
R
G
F
V
K
A
G
----
E
R
L
L
G
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
-
E
K
K
P
L
E
R
I
R
D
D
I
Y
Y
P
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
G
--
4
PsiBlast_PDB
83.81
40%
-102
- C1 -
3BK1
7
RNJ_THET2
A:
[15-560]
--------
D
H
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
E
G
--------------------
M
P
G
-------
V
D
L
L
I
P
R
V
D
Y
L
------------
I
E
-----
H
R
H
K
I
K
A
W
V
L
T
H
G
H
E
D
H
I
G
G
L
P
F
L
L
P
M
I
FG
K
E
--
S
-----
P
V
P
I
Y
G
A
R
L
T
L
G
L
L
R
G
K
L
E
E
F
G
L
---------
R
----------------
P
G
---------
A
F
N
L
K
E
I
S
P
D
D
R
I
Q
V
G
R
-
Y
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
T
I
V
H
-
T
G
D
F
K
L
D
P
T
P
I
D
G
K
V
-
S
----
H
L
A
K
V
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
-
G
Y
--------
T
P
--
S
E
M
E
I
A
K
E
L
D
R
V
I
G
-
R
A
---
P
--
G
R
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
------
K
-------
V
A
M
E
G
R
S
M
L
K
F
S
-
R
I
---
A
L
E
-
L
-
G
Y
L
K
V
------------------------
K
D
-------
R
L
-------
Y
T
---
L
-
E
E
V
K
D
-
L
--
P
D
H
Q
V
L
I
L
A
T
-
G
S
--
Q
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
S
S
P
I
P
G
N
E
-
E
A
-
V
--
N
-----
R
V
I
N
-----------
R
L
Y
-
A
L
G
----
A
Y
V
L
Y
-
P
P
--
T
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
------
H
G
E
V
R
H
Q
M
N
F
K
W
-
L
A
E
-
S
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
L
V
V
I
T
A
L
A
G
E
D
P
V
V
-----
E
V
V
S
R
G
F
V
K
A
G
E
R
L
L
G
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
-----
E
K
K
P
L
E
R
I
R
D
D
I
Y
Y
P
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
G
--
24
PsiBlast_CBE
77.05
42%
-104
- C1 -
5A0V
4
?
B:
[21-452]
------------
V
T
P
L
G
G
L
G
E
I
G
R
N
M
T
V
F
E
Y
G
G
R
L
L
I
V
D
C
G
V
L
F
P
E
E
E
--------------------
Q
P
G
-------
I
D
L
I
L
P
D
F
T
S
I
------------
R
D
-----
R
L
D
D
I
E
G
I
V
L
T
H
G
H
E
D
H
I
G
G
V
P
F
L
L
-----
R
E
--
K
P----
D
I
P
L
I
G
S
K
L
T
L
A
L
I
E
A
K
L
Q
E
H
-
R
---------
I
----------------
R
P
---------
Y
-
T
L
-
E
V
A
E
G
H
R
E
R
V
-
G
-
P
F
D
C
E
F
V
A
V
N
H
S
I
P
D
A
L
A
V
A
I
R
T
--
P
--
A
G
M
V
V
H
-
T
G
D
F
K
M
D
Q
L
P
L
D
G
R
L
-
T
----
D
L
H
A
F
A
R
L
S
E
E
G
I
D
L
L
L
A
D
S
T
N
A
E
V
P
-
G
F
--------
V
P
--
P
E
R
D
I
S
N
V
L
R
Q
V
F
A
-
N
A
---
R
--
K
R
I
I
V
A
S
F
A
S
H
V
H
R
I
Q
Q
I
L
D
A
A
H
E
Y
G
--------
R
------
R
-------
V
A
F
V
G
R
S
M
V
R
N
M
-
G
I
---
A
R
D
-
L
-
G
Y
L
K
V
--------------
P
---------
P
G
-------
L
V
-------
V
D
---
V
-
K
T
L
D
D
-
L
--
P
D
S
E
V
V
L
V
C
T
-
G
S
--
Q
G
E
P
M
A
A
L
S
R
M
A
N
R
D
H
-
Q
I
R
I
V
N
G
D
T
V
I
L
A
S
S
L
I
P
G
N
E
-
N
A
-
V
--
Y
-----
R
V
I
N
-----------
G
L
T
-
R
W
G
----
A
N
V
V
H
-
K
G
--
N
A
K
-
V
-
H
V
S
G
H
A
S
A
G
E
L
L
Y
F
Y
N
I
C
R
--
P
K
N
L
M
P
V
------
H
G
E
W
R
H
L
R
A
N
A
E
-
L
G
A
-
L
T
G
V
P
---
H
D
R
I
V
I
A
E
D
G
V
V
V
D
L
V
E
G
K
A
K
I
T
G
K
V
Q
A
G
Y
V
Y
V
D
--------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
77.03
42%
-105
- C1 -
5A0T
4
?
B:
[21-452]
------------
V
T
P
L
G
G
L
G
E
I
G
R
N
M
T
V
F
E
Y
G
G
R
L
L
I
V
D
C
G
V
L
F
P
E
E
E
--------------------
Q
P
G
-------
I
D
L
I
L
P
D
F
T
S
I
------------
R
D
-----
R
L
D
D
I
E
G
I
V
L
T
H
G
H
E
D
H
I
G
G
V
P
F
L
L
-----
R
E
--
K
P----
D
I
P
L
I
G
S
K
L
T
L
A
L
I
E
A
K
L
Q
E
H
-
R
---------
I
----------------
R
P
---------
Y
-
T
L
-
E
V
A
E
G
H
R
E
R
V
-
G
-
P
F
D
C
E
F
V
A
V
N
H
S
I
P
D
A
L
A
V
A
I
R
T
--
P
--
A
G
M
V
V
H
-
T
G
D
F
K
M
D
Q
L
P
L
D
G
R
L
-
T
----
D
L
H
A
F
A
R
L
S
E
E
G
I
D
L
L
L
A
D
S
T
N
A
E
V
P
-
G
F
--------
V
P
--
P
E
R
D
I
S
N
V
L
R
Q
V
F
A
-
N
A
---
R
--
K
R
I
I
V
A
S
F
A
S
H
V
H
R
I
Q
Q
I
L
D
A
A
H
E
Y
G
--------
R
------
R
-------
V
A
F
V
G
R
S
M
V
R
N
M
-
G
I
---
A
R
D
-
L
-
G
Y
L
K
V
--------------
P
---------
P
G
-------
L
V
-------
V
D
---
V
-
K
T
L
D
D
-
L
--
P
D
S
E
V
V
L
V
C
T
-
G
S
--
Q
G
E
P
M
A
A
L
S
R
M
A
N
R
D
H
-
Q
I
R
I
V
N
G
D
T
V
I
L
A
S
S
L
I
P
G
N
E
-
N
A
-
V
--
Y
-----
R
V
I
N
-----------
G
L
T
-
R
W
G
----
A
N
V
V
H
-
K
G
--
N
A
K
-
V
-
H
V
S
G
H
A
S
A
G
E
L
L
Y
F
Y
N
I
C
R
--
P
K
N
L
M
P
V
------
H
G
E
W
R
H
L
R
A
N
A
E
-
L
G
A
-
L
T
G
V
P
---
H
D
R
I
V
I
A
E
D
G
V
V
V
D
L
V
E
G
K
A
K
I
T
G
K
V
Q
A
G
Y
V
Y
V
D
--------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.87
42%
-103
- C1 -
5A0V
3
?
A:
[21-455]
------------
V
T
P
L
G
G
L
G
E
I
G
R
N
M
T
V
F
E
Y
G
G
R
L
L
I
V
D
C
G
V
L
F
P
E
E
E
--------------------
Q
P
G
-------
I
D
L
I
L
P
D
F
T
S
I
------------
R
D
-----
R
L
D
D
I
E
G
I
V
L
T
H
G
H
E
D
H
I
G
G
V
P
F
L
L
-----
R
E
--
K
P----
D
I
P
L
I
G
S
K
L
T
L
A
L
I
E
A
K
L
Q
E
H
-
R
---------
I
----------------
R
P
---------
Y
-
T
L
-
E
V
A
E
G
H
R
E
R
V
-
G
-
P
F
D
C
E
F
V
A
V
N
H
S
I
P
D
A
L
A
V
A
I
R
T
--
P
--
A
G
M
V
V
H
-
T
G
D
F
K
M
D
Q
L
P
L
D
G
R
L
-
T
----
D
L
H
A
F
A
R
L
S
E
E
G
I
D
L
L
L
A
D
S
T
N
A
E
V
P
-
G
F
--------
V
P
--
P
E
R
D
I
S
N
V
L
R
Q
V
F
A
-
N
A
---
R
--
K
R
I
I
V
A
S
F
A
S
H
V
H
R
I
Q
Q
I
L
D
A
A
H
E
Y
G
--------
R
------
R
-------
V
A
F
V
G
R
S
M
V
R
N
M
-
G
I
---
A
R
D
-
L
-
G
Y
L
K
V
--------------
P
---------
P
G
-------
L
V
-------
V
D
---
V
-
K
T
L
D
D
-
L
--
P
D
S
E
V
V
L
V
C
T
-
G
S
--
Q
G
E
P
M
A
A
L
S
R
M
A
N
R
D
H
-
Q
I
R
I
V
N
G
D
T
V
I
L
A
S
S
L
I
P
G
N
E
-
N
A
-
V
--
Y
-----
R
V
I
N
-----------
G
L
T
-
R
W
G
----
A
N
V
V
H
-
K
G
--
N
A
K
-
V
-
H
V
S
G
H
A
S
A
G
E
L
L
Y
F
Y
N
I
C
R
--
P
K
N
L
M
P
V
------
H
G
E
W
R
H
L
R
A
N
A
E
-
L
G
A
-
L
T
G
V
P
---
H
D
R
I
V
I
A
E
D
G
V
V
V
D
L
V
E
G
K
A
K
I
T
G
K
V
Q
A
G
Y
V
Y
V
D
G
L
S
-----------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.76
42%
-104
- C1 -
5A0T
4
?
A:
[21-455]
------------
V
T
P
L
G
G
L
G
E
I
G
R
N
M
T
V
F
E
Y
G
G
R
L
L
I
V
D
C
G
V
L
F
P
E
E
E
--------------------
Q
P
G
-------
I
D
L
I
L
P
D
F
T
S
I
------------
R
D
-----
R
L
D
D
I
E
G
I
V
L
T
H
G
H
E
D
H
I
G
G
V
P
F
L
L
-----
R
E
--
K
P----
D
I
P
L
I
G
S
K
L
T
L
A
L
I
E
A
K
L
Q
E
H
-
R
---------
I
----------------
R
P
---------
Y
-
T
L
-
E
V
A
E
G
H
R
E
R
V
-
G
-
P
F
D
C
E
F
V
A
V
N
H
S
I
P
D
A
L
A
V
A
I
R
T
--
P
--
A
G
M
V
V
H
-
T
G
D
F
K
M
D
Q
L
P
L
D
G
R
L
-
T
----
D
L
H
A
F
A
R
L
S
E
E
G
I
D
L
L
L
A
D
S
T
N
A
E
V
P
-
G
F
--------
V
P
--
P
E
R
D
I
S
N
V
L
R
Q
V
F
A
-
N
A
---
R
--
K
R
I
I
V
A
S
F
A
S
H
V
H
R
I
Q
Q
I
L
D
A
A
H
E
Y
G
--------
R
------
R
-------
V
A
F
V
G
R
S
M
V
R
N
M
-
G
I
---
A
R
D
-
L
-
G
Y
L
K
V
--------------
P
---------
P
G
-------
L
V
-------
V
D
---
V
-
K
T
L
D
D
-
L
--
P
D
S
E
V
V
L
V
C
T
-
G
S
--
Q
G
E
P
M
A
A
L
S
R
M
A
N
R
D
H
-
Q
I
R
I
V
N
G
D
T
V
I
L
A
S
S
L
I
P
G
N
E
-
N
A
-
V
--
Y
-----
R
V
I
N
-----------
G
L
T
-
R
W
G
----
A
N
V
V
H
-
K
G
--
N
A
K
-
V
-
H
V
S
G
H
A
S
A
G
E
L
L
Y
F
Y
N
I
C
R
--
P
K
N
L
M
P
V
------
H
G
E
W
R
H
L
R
A
N
A
E
-
L
G
A
-
L
T
G
V
P
---
H
D
R
I
V
I
A
E
D
G
V
V
V
D
L
V
E
G
K
A
K
I
T
G
K
V
Q
A
G
Y
V
Y
V
D
G
L
S
-----------------------------------------------------------------------------------------------------------------
40
HHSearch
53.26
17%
-86
- C1 -
2AZ4
2
?
A:
[5-428]
--------
A
K
T
T
V
T
F
H
S
G
I
L
T
I
G
G
T
V
I
E
V
A
Y
K
D
A
H
I
F
F
D
F
G
T
E
F
R
P
E
L
D-------------------
L
P
D
DH
I
E
T
L
I
N
N
R
L
V
P
E
L
K
D
L
YDPRLG
Y
E
Y
H
G
A
E
D
-----
K
D
Y
Q
H
T
A
V
F
L
S
H
A
H
L
D
H
S
R
M
I
N
Y
L
D
-----
P
A
---------
V
P
L
Y
T
L
K
E
T
K
M
I
L
N
S
L
N
R
K
G
D
F
LIPSPFEEK
N
----------------
F
T
---------
R
-
E
M
I
G
L
N
K
N
D
V
I
K
V
-
G
-
E
I
S
V
E
I
V
P
V
D
H
D
A
Y
G
A
S
A
L
L
I
R
T
--
P
--
D
H
F
I
T
Y
-
T
G
D
L
R
L
H
G
H
N
R
-----
E
----
E
T
L
A
F
C
E
K
A
-
K
H
T
E
L
L
M
M
E
G
V
S
I
S
F
P
-
E
R
EPDPAQIA
V
V
--
S
E
E
D
L
V
Q
H
L
V
R
L
E
L
-
E
N
---
P
N-
R
Q
I
T
F
N
G
Y
P
A
N
V
E
R
F
A
K
I
I
---
E
K
S
P
--------
R
------
T
-------
V
V
L
E
A
N
M
A
A
L
L
L
-
E
V
FG
I
E
V
R
-
Y
-
Y
Y
A
E
-------------------------
S
G
-------
K
I
-------
P
E
---
L
-
N
P
A
L
E
-
I
--
P
Y
D
-
T
L
L
--
K
-
D
K
--
T
D
Y
L
W
Q
V
V
N
Q
F
-------
D
N
L
Q
E
G
S
L
Y
I
H
S
D
A
Q
P
L
G
D
F
-
D
P
Q
Y
--
R
-----
V
F
L
D
-----------
L
L
A
-
K
K
D
----
I
T
F
V
R
---------
L
-
A
C
S
G
H
A
I
P
E
D
L
D
K
I
I
A
L
I
E
--
P
Q
V
L
V
P
I
------
H
T
L
K
P
E
K
L
--
E
N
-
P
Y
G
----------
E
R
I
-
L
P
E
R
G
E
Q
I
V
L
---------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
52.50
17%
-81
- C1 -
2AZ4
2
?
A:
[5-429]
--------
A
K
T
T
V
T
F
H
S
G
I
L
T
I
G
G
T
V
I
E
V
A
Y
K
D
A
H
I
F
F
D
F
G
T
E
F
R
P
E
L
DLPDDH
I
E
T
L
I
N
N
RLVPELK
D
L
Y
-------
D
P
R
L
G
Y
E
Y
H
G
A
------------
E
D
-----
K
D
Y
Q
H
T
A
V
F
L
S
H
A
H
L
D
H
S
R
M
I
N
Y
L
D
-----
P
---------
A
V
P
L
Y
T
L
K
E
T
K
M
I
L
N
S
L
N
R
K
G
D
F
---------
L
----------------
I
P
SPFEEKNFT
R
-
E
M
I
G
L
N
K
N
D
V
I
K
V
-
G
-
E
I
S
V
E
I
V
P
V
D
H
D
A
Y
G
A
S
A
L
L
I
R
T
--
P
--
D
H
F
I
T
Y
-
T
G
D
L
R
L
H
G
H
N
R
-
E
E
T
-
L
A
F
C
E
K
A
K
H
T
E
L
L
M
M
E
G
V
S
I
S
F
P
E
R
E
P
D
P
A
Q
-
I
A
--------
V
V
--
S
E
E
D
L
V
Q
H
L
V
R
L
E
L
E
N
P
---
N
--
R
Q
I
T
F
N
G
Y
P
A
N
V
E
R
F
A
K
I
I
E
K
S
---
P
--------
R
------
T
-------
V
V
L
E
A
N
M
A
A
L
L
L
E
V
F
---
G
I
E
-
V
-
R
Y
Y
Y
A
--------------
E
---------
S
G
-------
K
I
-------
P
E
---
L
-
N
P
A
L
E
-
I
--
P
Y
D
T
L
L
K
D
K
T
-
D
Y
--
L
W
Q
V
V
N
Q
F
D
N
L
Q
----------
E
G
S
L
Y
I
H
S
D
A
Q
P
L
G
D
F
D
P
Q
-
Y
--
R
-----
V
F
L
D
-----------
L
L
A
-
K
K
D
----
I
T
F
V
R
---------
L
-
A
C
S
G
H
A
I
P
E
D
L
D
K
I
I
A
L
I
E
--
P
Q
V
L
V
P
I
------
H
T
L
K
P
E
K
L
E
N
-----------
P
---
Y
G
E
R
I
L
P
E
R
G
E
Q
I
V
L
---------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
51.85
21%
-81
- C1 -
3AF5
13
?
A:
[186-650]
-------
S
R
W
I
R
I
T
G
L
G
G
F
R
E
V
G
R
S
A
L
L
V
Q
T
D
E
S
F
V
L
V
D
F
G
V
N
V
A
M
L
N
D
P
Y
K
A
---------------
F
P
H
-------
F
--
D
A
P
E
F
Q
Y
V
-------------
L
-----
R
E
G
L
L
D
A
I
I
I
T
H
A
H
L
D
H
C
G
M
L
P
Y
L
F
-----
R
Y
NL
F
-----
D
G
P
I
Y
T
T
P
P
T
R
D
L
M
V
L
L
Q
K
D
F
I
E
I
--------
Q
Q
S
N
GQDPLYR
P
R
D
I
K
E
V
I
---------
K
-
H
T
I
T
L
D
Y
G
E
V
R
D
I
-
S
P
D
I
R
L
T
L
H
N
A
G
H
-
I
L
G
S
A
I
V
H
L
H
I
--
G
NG
L
H
N
I
A
I
-
T
G
D
F
K
F
I
P
T
R
L
-
L
E
--------
P
A
N
-
A
K
--
F
P
R
L
E
T
L
V
M
E
S
T
Y
G
G
A
N
-
D
I
--------
Q
M
--
P
R
E
E
A
E
K
R
L
I
E
V
I
H
-
N
T
I
K
R
G
--
G
K
V
L
I
P
A
M
A
--
V
G
R
A
Q
E
V
M
M
V
L
E
E
Y
A
--------
R
I
GGIE
V
P
-------
I
Y
L
D
G
M
I
W
E
-
A
T
-
A
I
---
H
T
A
-
Y
P
E
Y
L
S
R
R
L
R
E
Q
I
FKEGYNPF
L
---------
S
E
-------
I
F
-------
H
P
VAN
S
-
R
E
R
Q
D
I
I
D
-
S
N
E
P
A
I
I
I
A
S
S
G
M
LV
G
G
P
S
V
E
Y
F
K
Q
L
A
--------
P
D
P
K
N
S
I
I
F
V
S
Y
Q
A
E
G
T
L
-
G
R
Q
V
--
Q
-----
S
G
I
R
-----------
E
I
P
-
M
V
G
EEG
R
T
E
V
I
K
-
V
N
M
E
V
H
T
I
D
-
G
F
S
G
H
A
D
R
R
E
L
M
N
Y
V
A
K
V
R
PR
P
E
R
I
I
T
V
------
H
G
E
P
Q
K
C
L
D
L
A
T
S
I
H
R
-
K
F
G
I
S
------
T
R
A
P
N
N
L
D
T
I
R
L
R
--------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
50.97
20%
-92
- C1 -
5AHR
2
A:
[1-343]
----------------------------------------------
S
M
--------------------
T
C
P
-------
F
Y
K
K
I
P
G
T
G
F
T
------------
V
D
AFQYG
V
V
E
G
C
T
A
Y
F
L
T
H
F
H
S
D
H
Y
A
G
L
S
--------
K
H
--
F
-----
T
F
P
V
Y
C
S
E
I
T
G
N
L
L
K
N
K
L
H
-------------
V
----------------
Q
E
---------
Q
-
Y
I
H
P
L
P
L
D
T
E
C
I
V
-
N
-
G
V
K
V
V
L
L
D
A
N
H
C
-
P
G
A
V
M
I
L
F
Y
L
--
P
--
N
G
T
V
I
L
H
T
G
D
F
R
A
D
---------
P
----
S
M
E
R
-
S
L
L
A
D
Q
K
V
H
M
L
Y
L
D
T
T
Y
C
S
P
E
Y
T
F
--------
P
S
--
Q
Q
E
V
I
R
F
A
I
N
T
A
F
E
-
A
V
---
T
L
N
P
H
A
L
V
V
C
G
T
Y
S
I
G
K
E
K
V
F
L
A
I
A
D
V
L
G
--------
S
------
K
-------
V
G
-----
M
S
Q
E
K
-
Y
K
---
T
L
Q
-
C
-
L
N
I
P
E
--------------
I
---------
N
S
-------
L
I
-------
T
T
---
D
-
M
C
S
S
L
-
V
--
H
L
L
P
M
M
Q
I
-------
N
F
K
G
L
Q
S
H
L
K
K
C
G
G
K
Y
N
-------
Q
I
L
A
F
R
P
T
V
I
P
Q
T
K
-
G
-----------------------------------------
N
-
I
S
--
I
Y
G
-
I
-
P
Y
S
E
H
S
S
Y
L
E
M
K
R
F
V
Q
W
L
K
--
P
Q
K
I
I
P
T
VNVGT
W
K
S
R
S
T
M
E
K
Y
F
R
E
-
W
K
L
-
E
A
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
49.22
18%
-90
* C1 *
3IEK
22
RNSE_THET8
A:
[1-431]
----------
M
R
I
V
P
F
G
A
A
R
E
V
T
G
S
A
H
L
L
L
A
G
G
R
R
V
L
L
D
C
G
M
F
Q
G
K
E
E
--------------------
A
-----------
R
N
H
A
P
F
---------------
G
F
-----
D
P
K
E
V
D
A
V
L
L
T
H
A
H
L
D
H
V
G
R
L
P
K
L
F
-----
R
E
G-
Y
-----
R
G
P
V
Y
A
T
R
A
T
V
L
L
M
E
I
V
L
E
D
A
L
K
VMDEPF---
F
G
P
E
D
V
E
E
---------
A
L
---------
G
-
H
L
R
P
L
E
Y
G
E
W
L
R
L
-
G
-
A
L
S
L
A
F
G
Q
A
G
H
-
L
P
G
S
A
F
V
V
A
Q
G
--
E
--
G
R
T
L
V
Y
-
S
G
D
L
G
N
R
E
K
D
V
-
L
P
-------
D
----
P
S
L
P
-
P
L
A
D
L
V
L
A
E
G
T
Y
G
D
R
P
-
H
R
--------
P
Y
R
E
T
V
R
E
F
L
E
I
L
E
K
T
L
S
--
Q
---
G
--
G
K
V
L
I
P
T
F
A
--
V
E
R
A
Q
E
I
L
Y
V
L
Y
T
H
G
HRL
P
R
---
A
------
P
-------
I
Y
L
D
S
P
M
A
G
R
V
L
-
S
L
---
Y
P
R
L
V
-
R
Y
F
S
E
--------------
E
V
Q
A
H
F
L
Q
G-
K
N
PFRPAG
L
E
V
-------
V
E
---
H
T
E
A
S
K
A
-
L
N
R
A
P
G
P
M
V
V
L
A
G
S
G
M
LA
G
G
R
I
L
H
H
L
K
H
G
L
S
--------
D
P
R
N
A
L
V
F
V
G
Y
Q
P
Q
G
G
L
-
G
A
-
E
I
I
A
RPP
A
V
R
I
L
G
-----------
E
E
V
-
P
L
R
----
A
S
V
H
T
-------
L
-
G
-
G
F
S
G
H
A
G
Q
D
E
L
L
D
W
L
Q
--
G
--
E
P
R
V
V
L
V
------
H
G
E
E
E
K
L
L
A
L
G
K
-
L
L
A
-
L
R
G
Q
E
------
V
S
L
A
R
F
G
E
G
V
P
V
---------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
48.95
17%
-82
- C1 -
2I7T
3
CPSF3_HUMAN
A:
[9-458]
-------
S
D
Q
L
L
I
R
P
L
G
A
G
Q
E
V
G
R
S
C
I
I
L
E
F
K
G
R
K
I
M
L
D
C
G
I
H
P
G
L
E
-----------------------
G
-------
M
-
D
A
L
P
Y
I
D
L
--------------
I
-----
D
P
A
E
I
D
L
L
L
I
S
H
F
H
L
D
H
C
G
A
L
P
W
F
L
-----
Q
K
--
T
SF---
K
G
R
T
F
M
T
H
A
T
K
A
I
Y
R
W
L
L
S
D
Y
V
K
----------LYT
E
T
D
L
E
E
-------
S
M
---------
D
-
K
I
E
T
I
N
F
H
E
V
K
E
V
-
A
-
G
I
K
F
W
C
Y
H
A
G
H
-
V
L
G
A
A
M
F
M
I
E
I
--
A
--
G
V
K
L
L
Y
-
T
G
D
F
S
R
Q
--------------
M
A
A
---
E
I
P
N
I
K
P
D
I
L
I
I
E
S
T
Y
G
T
H
I
-
H
E
--------
K
R
E
E
R
E
A
R
F
C
N
T
V
H
D
I
V
N
-
R
----
G
--
G
R
G
L
I
P
V
F
A
--
L
G
R
A
Q
E
L
L
L
I
L
D
E
Y
W
Q
N
H
PELHD
I
------
P
-------
I
Y
Y
A
-----------------------------------------------------------
F
-------
K
H
I
S
N
L
-
K
S
M
D
H
F
D
--
D
I
G
P
S
V
V
M
A
S
P
G
M
MQ
S
G
L
S
R
E
L
F
E
S
W
--------
C
T
D
K
R
N
G
V
I
I
A
G
Y
C
V
E
G
T
L
-
A
K
-
H
--
I
M
----
S
E
P
E
-----------
E
I
T
T
M
S
G
----
Q
K
L
P
L
K
M
S
--
V
D
Y
-
I
-
S
F
S
A
H
T
D
Y
Q
Q
T
S
E
F
I
R
A
L
K
--
P
P
H
V
I
L
V
------
H
G
E
Q
N
E
M
A
R
L
K
A
A
L
I
R
-
E
Y
E
D
N
DE
V
H
I
E
V
H
N
P
R
N
T
E
A
V
T
L
N
F
R
------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
48.27
19%
-79
- C1 -
2YCB
7
?
A:
[178-636]
--------
D
W
A
R
L
T
A
M
G
G
F
R
E
V
G
R
S
C
L
Y
L
Q
T
P
N
S
R
V
L
L
D
C
G
V
N
V
A
G
G
D
--------------------
D
----------
K
N
S
Y
P
Y
L
N
V
P
------------
E
F
-----
T
L
D
S
L
D
A
V
I
I
T
H
A
H
L
D
H
S
G
F
L
P
Y
L
Y
-----
H
Y
--
G
Y----
D
G
P
V
Y
C
T
A
P
T
R
D
L
M
T
L
L
Q
L
D
H
I
D
I
A
H
R
E
DEPL
P
FN
V
K
H
V
K
K
--------
S
V
---------
K
-
H
T
I
T
L
D
Y
G
E
V
T
D
I
A
P
-
D
I
R
L
T
L
H
N
A
G
H
-
I
L
G
S
A
M
A
H
L
H
I
GD
G
--
Q
H
N
M
V
Y
-
T
G
D
F
K
Y
E
Q
S
R
L
-
L
E
----------
A
A
A
N
-
R
F
P
R
I
E
T
L
V
M
E
S
T
Y
G
G
H
E
-
D
V
--------
Q
P
--
S
R
N
R
A
E
K
E
L
V
K
T
I
Y
-
S
T
L
R
R
G
--
G
K
I
L
I
P
V
F
A
--
V
G
R
A
Q
E
L
M
I
V
L
E
E
Y
I
--------
R
------
T
GIIDE
V
P
V
Y
I
D
G
M
I
W
E
-
A
N
-
A
I
---
H
T
A
R
P
-
E
Y
L
S
K
--------------
D
L
R
D
Q
I
FHMG
H
N
-------
P
F
ISDI
F
H
K
V
N
G
--
M
-
D
E
R
R
E
-
I
V
E
G
E
P
S
I
I
L
S
T
S
-
G
M
LT
G
G
N
S
L
E
Y
F
K
W
L
C
E
--------
D
P
D
N
S
L
V
F
V
G
Y
Q
A
E
G
S
L
-
G
R
-
R
--
I
Q
----
K
G
W
K
E
I
P
L
K
D
EDD
K
M
R
V
Y
-
N
V
R
----
M
N
I
K
--------
T
-
I
E
G
F
S
G
H
S
D
R
R
Q
L
M
E
Y
V
K
R
I
S
PK
P
E
K
I
L
L
C
------
H
G
D
N
Y
K
T
L
D
L
A
S
-
S
I
Y
R
T
Y
R
I
------
E
T
K
T
P
L
N
L
E
T
V
R
I
Q
--------------------------------------------------------------------------------------------------------------------------------------