@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1809: (2015-12-10 )
MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTIKYIIEQGGRAILFSHLGRVKEEADKEGKSLAPVAADLAAKLGQDVVFPGVTRGAKLEEAINALEDGQVLLVENTRFEDVDGKKESKNDEELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEKADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKDLLEKSNGKLILPVDSKEANAFAGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQLGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK
Atome Classification :
(51 SA)
.........-10........20.......-.30........40........50.-.-..-....60........70........80........-90..-----.......-100.......110.......120.--------....---.----------.-..130......---.140---..--.....150.......160.......170-........180.......190.......200.......210....--..--.220.......230...-.-...240.....-------..250.......--260-..---.---......270.......280--.-.-.--.....-290.......300.......310.......320.......330.......340--..--.--.--...350.......360.......370.......380.......390......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
K
L
T
V
K
D
V-DLKG
K
K
V
L
V
R
V
D
FNVPLKD-
G
V
ITNDN
R
I
T
A
A
L
P
T
I
K
Y
I
I
E
QGG-R-
A
I
-
L
F
S
H
L
G
R
V
K
E
E
A
DKEGKSLA
P
V
A
A
D
L
A
A
K
LGQDV-V-FP-----GVTRG
A
K
-
L
E
E
A
I
N
ALEDG
Q
V
L
L
V
ENTRF--E--------DVDG---K----------K-ESK
N
D
E
E
L
G
K
Y
---
W
A
S
L---GD--
G
I
F
V
NDAFGTAHRAHASNVGIS
A
N
V
E
K
--
A
V
A
G
F
L
LE
N
E
I
A
Y
I
Q
E
A
VETPER
P
F
V
A
I
LGGSKV
S
D
K
I
G
V
I
E
N
L
L
--
E
K--AD
K
V
L
IGG
G
M
T
Y
T
F
Y
K
A-Q-GIEI
G
N
S
L
V
E
E
-------
D
K
L
D
V
A
K
D
L
L
E
K--S---N
G
---
K
---
L
I
L
PVDSKEANAFAGYTE---V-R-D--TEG
E
A
-VSE
G
F
L
G
L
DI
G
P
K
S
I
A
K
F
D
E
A
LTGA
K
T
V
V
WNGPMGVFENPDFQAG
T
I
G
V
M
D
A
I
--
V
K
--Q--L--G
V
K
S
IIGGGDS
A
A
A
A
I
NLGRAD
K
F
S
W
I
STGGGA
S
M
E
LLEGKVLP
G
L
A
A
LTEK
1
PsiBlast_PDB
97.22
63%
-74
- C8 -
4DG5
-
PGK_STAAR
A:
[2-396]
-
A
K
K
I
V
S
D
L
-
D
L
K
G
K
T
V
L
V
R
A
D
F
N
V
P
L
K
D
-
G
E
I
T
N
D
N
R
I
V
Q
A
L
P
T
I
Q
Y
I
I
E
Q
G
G
-
K
-
I
V
-
L
F
S
H
L
G
K
V
K
E
E
S
D
K
A
K
L
T
L
R
P
V
A
E
D
L
S
K
K
L
D
K
E
V
-
V
-
F
V
-----
P
E
T
R
G
E
K
-
L
E
A
A
I
K
D
L
K
E
G
D
V
L
L
V
E
N
T
R
Y
--
E
--------
D
L
D
G
---
K
----------
K
-
E
S
K
N
D
P
E
L
G
K
Y
---
W
A
S
L
---
G
D
---
V
F
V
N
D
A
F
G
T
A
H
R
E
H
A
S
N
V
G
I
S
T
H
L
E
T
--
A
-
A
G
F
L
M
D
K
E
I
K
F
I
G
G
V
V
N
D
P
H
K
P
V
V
A
I
L
G
G
A
K
V
S
D
K
I
N
V
I
K
N
L
V
--
N
I
--
A
D
K
I
I
I
G
G
G
M
A
Y
T
F
L
K
A
-
Q
-
G
K
E
I
G
I
S
L
L
E
E
-------
D
K
I
D
F
A
K
D
L
L
E
K
--
H
---
G
D
---
K
---
I
V
L
P
V
D
T
K
V
A
K
E
F
S
N
D
A
K
---
I
-
T
-
V
--
V
P
S
D
S
-
I
P
A
D
Q
E
G
M
D
I
G
P
N
T
V
K
L
F
A
D
E
L
E
G
A
H
T
V
V
W
N
G
P
M
G
V
F
E
F
S
N
F
A
Q
G
T
I
G
V
C
K
A
I
--
A
N
--
L
--
K
--
D
A
I
T
I
I
G
G
G
D
S
A
A
A
A
I
S
L
G
F
E
N
D
F
T
H
I
S
T
G
G
G
A
S
L
E
Y
L
E
G
K
E
L
P
G
I
K
A
I
N
N
K
63
HHSearch
94.50
57%
-80
- C8 -
1VPE
3
PGKT_THEMA
A:
[2-396]
--
K
M
T
I
R
D
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
-
L
L
S
H
L
G
R
P
K
G
E
P
S
-
P
E
F
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
-
K
F
V
P
-----
A
-
V
V
G
D
E
-
V
K
K
A
V
E
E
L
K
E
G
E
V
L
L
L
E
N
T
R
F
--
H
--------
P
G
E
------------------
T
K
N
D
P
E
L
A
K
F
---
W
A
S
L
---
A
D
---
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
I
P
---
S
V
A
G
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
M
--
E
K
--
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
-
L
-
G
K
E
V
G
S
S
R
V
E
E
-------
D
K
I
D
L
A
K
E
L
V
E
K
--
A
K
E
-
K
G
---
V
E
--
I
V
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
V
E
---
K
-
K
-
V
V
-
R
I
D
D
G
-
I
P
E
G
W
M
G
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
--
A
A
--
L
--
T
E
K
G
A
I
T
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
2
PsiBlast_PDB
94.26
56%
-83
- C8 -
1VPE
3
PGKT_THEMA
A:
[2-393]
--
K
M
T
I
R
D
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
-
L
L
S
H
L
G
R
P
K
G
E
P
S
P
E
F
-
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
-
K
-
F
V
-----
P
A
V
V
G
D
E
-
V
K
K
A
V
E
E
L
K
E
G
E
V
L
L
L
E
N
T
R
F
--
H
---------------
P
----------
G
-
E
T
K
N
D
P
E
L
A
K
F
---
W
A
S
L
---
A
D
---
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
I
-
P
--
S
V
A
G
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
M
--
E
K
--
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
-
L
-
G
K
E
V
G
S
S
R
V
E
E
-------
D
K
I
D
L
A
K
E
L
V
E
K
--
A
---
K
E
---
K
G
V
E
I
V
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
V
E
K
K
V
V
-
R
-
I
--
D
D
G
---
I
P
E
G
W
M
G
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
A
A
L
T
--
E
--
K
--
G
A
I
T
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
7
PsiBlast_PDB
93.58
47%
-87
- C8 -
1QPG
2
PGK_YEAST
A:
[4-414]
-
S
K
L
S
V
Q
D
L
-
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
-
L
A
S
H
L
G
Q
P
N
G
E
R
N
-
E
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
-
T
-
F
L
-----
N
D
C
V
G
P
E
-
V
E
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--
H
IEEEG
S
R
-
K
V
D
G
---
Q
----------
K
-
V
K
A
S
K
E
D
V
Q
K
F
R
H
E
L
S
S
L
---
A
D
---
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
--
D
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
K
--
A
---
K
A
---
K
G
V
E
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
---
T
-
K
-
T
V
-
T
D
K
E
G
-
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
--
V
K
--
S
S
A
A
--
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
8
PsiBlast_PDB
93.06
46%
-80
- C8 -
2XE6
1
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
36
PsiBlast_CBE
92.48
46%
-79
- C8 -
4O33
2
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
T
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
58
HHSearch
92.37
51%
-76
- C8 -
1PHP
2
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
D
V
-
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
-
L
A
S
H
L
G
R
P
K
G
K
V
V
-
E
E
L
R
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
-
A
K
T
N
-----
E
-
A
V
G
D
E
-
V
K
A
A
V
D
R
L
N
E
G
D
V
L
L
L
E
N
V
R
F
--
Y
--------
P
G
------------------
E
E
K
N
D
P
E
L
A
K
A
---
F
A
E
L
---
A
D
---
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
L
P
---
A
V
A
G
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
L
--
E
K
--
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
-
L
-
G
H
D
V
G
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
E
K
--
A
K
E
-
K
G
---
V
R
--
F
Y
M
P
V
D
V
V
V
A
D
R
F
A
N
D
A
N
---
T
-
K
-
V
--
V
P
I
D
A
-
I
P
A
D
W
S
A
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
--
A
E
--
A
--
L
--
D
T
Y
S
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
44
PsiBlast_CBE
92.31
44%
-77
- C8 -
3OZ7
2
PGK_PLAF7
A:
[7-416]
--
K
L
S
I
S
D
L
K
D
I
K
N
K
K
V
L
V
R
V
D
F
N
V
P
I
E
N
-
G
I
I
K
D
T
N
R
I
T
A
T
L
P
T
I
N
H
L
K
K
E
G
A
S
K
-
I
I
-
L
I
S
H
C
G
R
-
P
D
G
L
R
N
E
K
Y
T
L
K
P
V
A
E
T
L
K
G
L
L
G
E
E
V
-
L
-
F
L
-----
N
D
C
V
G
K
E
-
V
E
D
K
I
N
A
A
K
E
N
S
V
I
L
L
E
N
L
R
F
--
H
IEEEG
K
G
V
D
A
N
G
---
N
----------
K
-
V
K
A
N
K
E
D
V
E
K
F
---
Q
N
D
L
---
T
K
L
A
D
V
F
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
K
L
N
V
K
----
A
S
G
F
L
M
K
K
E
L
E
Y
F
S
K
A
L
E
N
P
Q
R
P
L
L
A
I
L
G
G
A
K
V
S
D
K
I
Q
L
I
K
N
L
L
--
D
K
--
V
D
R
M
I
I
G
G
G
M
A
Y
T
F
K
K
V
L
N
-
N
M
K
I
G
T
S
L
F
D
E
-------
A
G
S
K
I
V
G
E
I
M
E
K
--
A
K
A
K
N
V
---
Q
---
I
F
L
P
V
D
F
K
I
A
D
N
F
D
N
N
A
N
---
T
-
K
-
F
V
-
T
D
E
E
G
-
I
P
D
N
W
M
G
L
D
A
G
P
K
S
I
E
N
Y
K
D
V
I
L
T
S
K
T
V
I
W
N
G
P
Q
G
V
F
E
M
P
N
F
A
K
G
S
I
E
C
L
N
L
V
--
V
E
V
T
K
--
K
--
G
A
I
T
I
V
G
G
G
D
T
A
S
L
V
E
Q
Q
N
K
K
N
E
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
L
A
L
S
N
-
43
PsiBlast_CBE
92.22
44%
-80
- C8 -
3OZ7
2
PGK_PLAF7
B:
[7-416]
--
K
L
S
I
S
D
L
K
D
I
K
N
K
K
V
L
V
R
V
D
F
N
V
P
I
E
N
-
G
I
I
K
D
T
N
R
I
T
A
T
L
P
T
I
N
H
L
K
K
E
G
A
S
K
-
I
I
-
L
I
S
H
C
G
R
-
P
D
G
L
R
N
E
K
Y
T
L
K
P
V
A
E
T
L
K
G
L
L
G
E
E
V
-
L
-
F
L
-----
N
D
C
V
G
K
E
-
V
E
D
K
I
N
A
A
K
E
N
S
V
I
L
L
E
N
L
R
F
--
H
IEEEG
K
G
V
D
A
N
G
---
N
----------
K
-
V
K
A
N
K
E
D
V
E
K
F
---
Q
N
D
L
---
T
K
LA
D
V
F
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
K
L
N
V
K
----
A
S
G
F
L
M
K
K
E
L
E
Y
F
S
K
A
L
E
N
P
Q
R
P
L
L
A
I
L
G
G
A
K
V
S
D
K
I
Q
L
I
K
N
L
L
--
D
K
--
V
D
R
M
I
I
G
G
G
M
A
Y
T
F
K
K
V
L
N
-
N
M
K
I
G
T
S
L
F
D
E
-------
A
G
S
K
I
V
G
E
I
M
E
K
--
A
K
A
K
N
V
---
Q
---
I
F
L
P
V
D
F
K
I
A
D
N
F
D
N
N
A
N
---
T
-
K
-
F
V
-
T
D
E
E
G
-
I
P
D
N
W
M
G
L
D
A
G
P
K
S
I
E
N
Y
K
D
V
I
L
T
S
K
T
V
I
W
N
G
P
Q
G
V
F
E
M
P
N
F
A
K
G
S
I
E
C
L
N
L
V
--
V
E
V
T
K
--
K
--
G
A
I
T
I
V
G
G
G
D
T
A
S
L
V
E
Q
Q
N
K
K
N
E
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
L
A
L
S
N
-
3
PsiBlast_PDB
92.22
49%
-75
- C8 -
1PHP
2
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
D
V
-
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
-
L
A
S
H
L
G
R
P
K
G
K
V
V
E
E
L
R
-
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
-
A
-
K
T
-----
N
E
A
V
G
D
E
-
V
K
A
A
V
D
R
L
N
E
G
D
V
L
L
L
E
N
V
R
F
--
Y
---------------
P
----------
G
-
E
E
K
N
D
P
E
L
A
K
A
---
F
A
E
L
---
A
D
---
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
-
A
H
Y
L
P
--
A
V
A
G
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
L
--
E
K
--
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
-
L
-
G
H
D
V
G
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
E
K
--
A
---
K
E
---
K
G
V
R
F
Y
M
P
V
D
V
V
V
A
D
R
F
A
N
D
A
N
---
T
-
K
-
V
--
V
P
I
D
A
-
I
P
A
D
W
S
A
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
--
A
E
--
A
--
L
--
D
T
Y
S
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
9
PsiBlast_PDB
92.13
46%
-75
- C8 -
2XE7
2
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
60
HHSearch
92.05
46%
-77
* C8 *
3Q3V
5
PGK_CAMJE
A:
[6-399]
-
D
I
I
S
I
K
D
I
-
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
-
L
A
S
H
L
G
R
P
K
E
I
S
--
S
K
Y
S
L
E
P
V
A
K
R
L
A
R
L
L
D
K
E
I
-
V
M
A
K
-----
D
-
V
I
G
E
D
-
A
K
T
K
A
M
N
L
K
A
G
E
I
L
L
L
E
N
L
R
F
--
E
--------
K
G
------------------
E
T
K
N
D
E
N
L
A
K
E
---
L
A
S
M
---
V
Q
---
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
F
D
E
KH
K
G
A
G
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
L
--
P
K
--
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
-
L
-
G
Y
D
I
G
N
S
L
L
E
E
-------
E
L
L
E
E
A
N
K
I
L
T
K
--
G
K
N
-
L
G
---
V
K
--
I
Y
L
P
V
D
V
V
A
A
P
A
C
S
Q
D
V
P
---
M
-
K
-
F
--
V
P
A
Q
E
-
I
P
N
G
W
M
G
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
--
S
E
--
G
-----
H
A
T
S
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
-
10
PsiBlast_PDB
92.01
46%
-78
- C8 -
2XE8
2
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
46
PsiBlast_CBE
91.99
45%
-79
- C8 -
1HDI
3
PGK1_PIG
A:
[2-411]
--
K
L
T
L
D
K
L
-
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
A
A
-
A
Q
I
T
N
N
A
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
S
P
M
P
D
K
Y
S
L
Q
P
V
A
A
E
L
K
S
A
L
G
K
A
V
-
L
-
F
L
-----
K
D
C
V
G
P
A
-
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
A
A
G
E
P
A
K
I
K
A
F
---
R
A
S
L
S
A
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
K
--
K
A
G
A
F
L
M
K
K
E
L
N
Y
F
A
A
A
A
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
A
G
K
K
I
V
K
N
L
M
S
K
A
A
A
---
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
Q
A
K
---
I
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
K
S
S
A
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
N
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
41
PsiBlast_CBE
91.90
45%
-81
- C8 -
2P9T
1
PGK2_MOUSE
A:
[4-414]
-
A
K
L
T
L
D
K
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
I
P
M
P
D
K
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
-
I
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
Q
A
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
S
S
G
---
K
----------
K
-
I
S
A
D
P
A
K
V
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
--
A
E
K
-
N
G
V
--
K
---
I
V
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
---
V
-
G
-
Q
--
A
T
I
E
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
--
V
K
--
A
--
T
S
N
G
C
V
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
M
40
PsiBlast_CBE
91.80
45%
-82
- C8 -
2PAA
1
PGK2_MOUSE
A:
[4-414]
-
A
K
L
T
L
D
K
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
I
P
M
P
D
K
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
-
I
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
Q
A
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
S
S
G
---
K
----------
K
-
I
S
A
D
P
A
K
V
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
--
A
E
K
-
N
G
V
--
K
---
I
V
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
---
V
-
G
-
Q
--
A
T
I
E
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
--
V
K
--
A
--
T
S
N
G
C
V
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
M
64
HHSearch
91.77
49%
-78
- C8 -
1QPG
2
PGK_YEAST
A:
[4-414]
-
S
K
L
S
V
Q
D
L
-
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
-
L
A
S
H
L
G
Q
P
N
G
E
R
N
-
E
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
-
T
F
L
N
-----
D
-
C
V
G
P
E
-
V
E
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--
H
--------
I
E
E
E
---
G
S
R
K
V
DGQKVK
A
-
S
K
E
D
V
Q
K
F
R
H
E
---
L
S
S
L
---
A
D
---
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
--
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
-
L
E
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
K
--
A
K
A
-
K
G
---
V
E
--
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
---
T
K
T
-
V
--
T
D
K
E
G
-
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
--
V
K
--
S
--
S
A
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
20
PsiBlast_PDB
91.70
46%
-84
- C8 -
2ZGV
1
PGK1_HUMAN
A:
[9-418]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
45
PsiBlast_CBE
91.57
46%
-80
- C8 -
4O3F
2
PGK1_MOUSE
A:
[6-415]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
A
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
N
A
C
A
N
P
A
A
G
T
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
D
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
Y
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
T
E
S
S
K
K
Y
A
E
A
V
G
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
S
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
--------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
61
HHSearch
91.40
50%
-76
- C8 -
1V6S
3
PGK_THET8
A:
[1-390]
--
M
R
T
L
L
D
L
-
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
-
L
L
S
H
L
G
R
P
K
G
P
D
--
P
K
Y
S
L
A
P
V
G
E
A
L
R
A
H
L
P
-
E
A
-
R
F
A
P
-----
F
-
P
P
G
S
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
--
E
--------
P
G
------------------
E
E
K
N
D
P
E
L
S
A
R
---
Y
A
R
L
---
G
E
---
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
P
---
A
Y
A
G
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
--
P
R
--
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
-
L
-
G
G
E
V
G
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
--
A
E
A
-
L
G
---
V
R
--
V
Y
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
---
T
-
R
-
V
--
F
P
A
R
A
-
I
P
V
P
Y
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
--
A
A
--
L
--
E
--
G
A
F
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
G
-
26
PsiBlast_CBE
91.37
46%
-73
- C8 -
2Y3I
5
PGK1_HUMAN
D:
[6-415]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEGKGK
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
SKL
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
EK-
N
G
V--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
AT
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
28
PsiBlast_CBE
91.35
46%
-80
- C8 -
3C3C
3
PGK1_HUMAN
A:
[9-418]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
19
PsiBlast_PDB
91.23
46%
-80
- C8 -
1VJD
2
PGK1_PIG
A:
[5-414]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
I
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
S
----------
K
-
V
K
A
D
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
K
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
57
HHSearch
91.03
47%
-73
- C8 -
2WZB
5
PGK1_HUMAN
A:
[3-415]
S
N
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
-
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
F
L
K
-----
D
-
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
--------
V
E
E
E
---
G
KG----------
E
P
A
K
I
E
A
F
R
A
S
---
L
S
K
L
---
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
-
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
---
V
K
--
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
--
A
--
T
S
R
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
35
PsiBlast_CBE
90.94
45%
-79
- C8 -
1KF0
3
PGK1_PIG
A:
[5-414]
--
K
L
T
L
D
K
L
-
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
S
P
M
P
D
K
Y
S
L
Q
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
K
T
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
K
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
N
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
H
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
18
PsiBlast_PDB
90.93
46%
-76
- C8 -
1VJC
1
PGK1_PIG
A:
[5-414]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
I
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
S
----------
K
-
V
K
A
D
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
K
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
12
PsiBlast_PDB
90.92
46%
-78
- C8 -
3ZOZ
5
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEGKG------------------------
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
13
PsiBlast_PDB
90.79
46%
-73
- C8 -
2Y3I
5
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
11
PsiBlast_PDB
90.77
46%
-78
- C8 -
2YBE
5
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEGKGK------------------
K
-
V
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
15
PsiBlast_PDB
90.74
46%
-79
- C8 -
2WZC
5
PGK1_HUMAN
A:
[5-414]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEGKG------------------------
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
14
PsiBlast_PDB
90.60
46%
-79
- C8 -
2WZB
5
PGK1_HUMAN
A:
[5-414]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEGKG------------------------
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
33
PsiBlast_CBE
90.59
46%
-84
- C8 -
3C39
1
PGK1_HUMAN
B:
[9-418]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
-------
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
25
PsiBlast_CBE
90.55
46%
-78
- C8 -
4AXX
5
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEGKGK----------------------
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
27
PsiBlast_CBE
90.50
46%
-81
- C8 -
3C3C
1
PGK1_HUMAN
B:
[9-418]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
-----
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
34
PsiBlast_CBE
90.48
46%
-85
- C8 -
3C39
1
PGK1_HUMAN
A:
[9-418]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEGKGK---------------------
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
16
PsiBlast_PDB
90.40
46%
-78
- C8 -
2X13
3
PGK1_HUMAN
A:
[5-414]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEGKGK---------------------
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
29
PsiBlast_CBE
90.31
46%
-83
- C8 -
3C3B
2
PGK1_HUMAN
B:
[9-418]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
-----
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
32
PsiBlast_CBE
90.28
46%
-80
- C8 -
3C3A
1
PGK1_HUMAN
A:
[9-418]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
---------
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
37
PsiBlast_CBE
90.16
46%
-77
- C8 -
2X14
3
PGK1_HUMAN
A:
[5-414]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEGKG------------------------
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
17
PsiBlast_PDB
90.09
46%
-81
- C8 -
2X15
3
PGK1_HUMAN
A:
[5-414]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEGKGK---------------------
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
31
PsiBlast_CBE
89.81
46%
-86
- C8 -
3C3A
3
PGK1_HUMAN
B:
[9-418]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
------
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEG
K
G
K
D
A
S
G
---
N
----------
K
-
V
K
A
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
39
PsiBlast_CBE
89.19
45%
-82
- C8 -
2PAA
1
PGK2_MOUSE
B:
[4-414]
-
A
K
L
T
L
D
K
V
-
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
I
P
M
P
D
K
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
-
I
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
Q
A
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
--
H
VEEEGKGK
D
S
S
G
---
K
----------
K
-
I
S
A
D
P
A
K
V
E
A
F
---
R
A
S
L
SKL
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
-
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
--
A
EK-
N
G
V--
K
---
I
V
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
---
V
-
G
-
Q
--
A
T
I
E
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
--
V
K
--
A
--
T
SN
G
C
V
T
I
I
G
---------------
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
M
38
PsiBlast_CBE
88.86
46%
-77
- C8 -
2WZD
5
PGK1_HUMAN
A:
[6-415]
--
K
L
T
L
D
K
L
-
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
-
S
V
V
L
M
S
H
L
G
R
P
D
G
V
P
M
P
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
-
L
-
F
L
-----
K
D
C
V
G
P
E
-
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
--
H
VEEEGKG------------------------
E
P
A
K
I
E
A
F
---
R
A
S
L
S
K
L
G
D
---
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
-
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
--
A
E
K
-
N
G
V
--
K
---
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
---
T
G
Q
-
A
--
T
V
A
S
G
-
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
K
A
T
S
--
R
--
G
C
I
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
48
PsiBlast_CBE
87.06
43%
-81
- C8 -
4NG4
2
PGK_COXBU
B:
[15-400]
---
L
S
M
S
N
L
-
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
-
I
L
S
H
L
G
R
P
E
E
G
K
F
E
K
E
F
S
L
A
P
V
A
R
L
L
S
K
K
L
N
-
K
V
P
L
-
I
N
-----
D
W
L
K
G
V
--------
A
V
E
P
G
Q
A
I
L
C
E
N
V
R
F
--------------
N
---
K
----------
G
-
E
N
E
N
N
T
E
L
A
K
R
---
M
A
E
L
---
C
D
---
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
K
--
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
--
A
A
E
K
N
V
---
S
---
L
P
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
---
A
-
T
-
V
--
K
N
I
D
A
-
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
--
A
K
--
S
--
T
--
A
Y
-
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
I
L
P
A
I
K
I
L
T
Q
R
47
PsiBlast_CBE
86.74
43%
-81
- C8 -
4NG4
2
PGK_COXBU
C:
[15-400]
---
L
S
M
S
N
L
-
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
-
I
L
S
H
L
G
R
P
E
E
G
K
F
E
K
E
F
S
L
A
P
V
A
R
L
L
S
K
K
L
N
--
V
P
L
-
I
N
-----
D
W
L
K
G
V
--------
A
V
E
P
G
Q
A
I
L
C
E
N
V
R
F
--------------
N
---
K
----------
G
-
E
N
E
N
N
T
E
L
A
K
R
---
M
A
E
L
---
C
D
---
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
K
--
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
--
A
A
E
K
N
V
---
S
---
L
P
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
---
A
-
T
-
V
--
K
N
I
D
A
-
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
--
A
K
--
S
--
T
--
A
Y
-
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
--
L
P
A
I
K
I
L
T
Q
R
50
PsiBlast_CBE
86.66
44%
-74
- C8 -
4FEY
1
PGK_FRATT
A:
[4-392]
M
S
F
L
T
L
K
D
V
-
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
D
-
G
K
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
-
L
M
S
H
L
G
R
P
T
E
G
E
Y
D
S
Q
F
S
L
E
P
V
A
K
A
L
S
E
I
I
N
K
P
V
-
K
-
F
A
KDWLD
G
V
D
V
K
A
------------
G
E
I
V
M
C
E
N
V
R
F
--
N
--------
S
--
G
---
E
----------
K
-
K
S
T
D
D
--
L
S
K
K
---
I
A
S
L
---
G
D
---
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
Y
I
P
V
--
A
C
A
G
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
L
--
D
K
--
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
-
E
-
G
F
D
V
G
N
S
L
Y
E
Q
-------
D
L
V
A
E
A
T
E
I
L
A
K
--
A
---
K
A
L
GV
N
---
I
P
V
P
V
D
V
R
V
A
K
E
F
S
E
N
A
Q
---
A
-
I
-
I
--
K
K
V
S
D
-
V
V
A
D
E
M
I
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
K
A
L
S
L
A
I
--
A
Q
--
S
--
H
--
A
F
-
S
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
49
PsiBlast_CBE
85.95
43%
-76
- C8 -
4NG4
2
PGK_COXBU
A:
[15-400]
---
L
S
M
S
N
L
-
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
-
I
L
S
H
L
G
R
P
E
E
G
K
F
E
K
E
F
S
L
A
P
V
A
R
L
L
S
K
K
-----P
L
-
I
N
-----
D
W
L
K
G
V
--------
A
V
E
P
G
Q
A
I
L
C
E
N
V
R
F
--------------
N
---
K
----------
G
-
E
N
E
N
N
T
E
L
A
K
R
---
M
A
E
L
---
C
D
---
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
K
--
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
-
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
--
A
A
E
K
N
V
---
S
---
L
P
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
---
A
-
T
-
V
--
K
N
I
D
A
-
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
--
A
K
--
S
--
T
--
A
Y
-
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
-
L
P
A
I
K
I
L
T
Q
R
54
PsiBlast_CBE
83.68
35%
-71
- C8 -
2CUN
5
PGK_PYRHO
A:
[2-398]
---
F
R
L
E
D
F
-
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
-
I
G
T
H
Q
G
K
P
Y
S
E
D
Y
T
T
T
E
E
H
A
R
V
L
S
E
L
---
L
D
Q
H
V
-
E
-
Y
I
-----
E
D
I
F
G
R
Y
-
A
R
E
K
I
K
E
L
K
S
G
E
V
A
I
L
E
N
L
R
F
SA
E
--------
E
V
K
N
---
K
----------
P
I
E
E
C
E
K
T
F
L
V
K
K
---
L
S
K
V
---
I
D
--
Y
V
-
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
-
A
R
I
K
P
--
M
I
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
R
R
E
R
--
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
F
D
L
G
R
K
N
V
E
F
M
K
K
K
GLL
D
Y
V
K
H
A
E
E
I
L
D
E
--
F
---
Y
P
---
Y
---
I
R
T
P
V
D
F
--
A
V
D
Y
K
G
E
R
V
---
E
-
I
-
D
LL
S
E
N
R
G
-
L
L
H
Q
Y
Q
I
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
--
A
D
--
S
--
P
--
A
F
-
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
-
I
T
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
53
PsiBlast_CBE
83.09
35%
-67
- C8 -
2CUN
5
PGK_PYRHO
B:
[2-398]
---
F
R
L
E
D
F
-
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
-
I
G
T
H
Q
G
K
P
Y
S
E
D
Y
T
T
T
E
E
H
A
R
V
L
S
E
L
---
L
D
Q
H
V
-
E
-
Y
I
-----
E
D
I
F
G
R
Y
-
A
R
E
K
I
K
E
L
K
S
G
E
V
A
I
L
E
N
L
R
F
SA
E
--------
E
V
K
N
---
K
----------
P
I
E
E
C
E
K
T
F
L
V
K
K
---
L
S
K
V
---
I
D
--
Y
V
-
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
-
A
R
I
K
P
--
M
I
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
RR
E
R
--
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
F
D
L
G
R
K
N
V
E
F
MKKKGLL
D
Y
V
K
H
A
E
E
I
L
D
E
--
F
---
Y
P
---
Y
---
I
R
T
P
V
D
F
--
A
V
D
Y
K
G
E
R
V
---
E
-
I
-
D
LL
S
E
N
R
G
-
L
L
H
Q
Y
Q
I
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
--
A
D
--
S
--
P
--
A
F
-
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
-
I
T
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
65
HHSearch
80.23
35%
-68
- C8 -
2CUN
5
PGK_PYRHO
A:
[1-401]
--
M
F
R
L
E
D
F
-
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
-
I
G
T
H
Q
G
K
P
Y
S
E
---
D
Y
T
T
T
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
-
E
Y
I
E
-----
D
-
I
F
G
R
Y
-
A
R
E
K
I
K
E
L
K
S
G
E
V
A
I
L
E
N
L
R
F
--
S
--------
A
E
E
V
K
N
K
P
----------
I
-
E
E
C
E
K
T
F
L
V
K
K
---
L
S
K
V
---
I
D
---
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
K
P
---
M
I
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
--
R
R
ER
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
-
K
-
G
F
D
L
G
R
K
N
V
E
F
M
K
K
K
GLL
D
Y
V
K
H
A
E
E
I
L
D
E
--
F
----
Y
---
P
Y--
I
R
T
P
V
D
F
A
V
D
Y
K
G
E
R
V
-
E
---
I
-
D
L
L
--
S
E
N
R
G
-
L
L
H
Q
Y
Q
I
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
--
A
D
--
S
-----
P
A
F
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
-
T
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
42
PsiBlast_CBE
67.68
47%
17
- C8 -
3PGK
3
PGK_YEAST
A:
[7-415]
-
S
K
L
S
V
Q
D
L
-
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
-
L
A
S
H
L
G
R
P
N
G
E
R
N
-
E
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
-
T
-
F
L
-----
N
D
C
V
G
P
E
-
V
E
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
--
H
IEEEGSR-
K
V
D
G
---
Q
----------
K
-
V
K
A
S
K
E
D
V
Q
K
F
R
H
E
L
S
S
L
---
A
D
---
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
--
D
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
-
N
T
E
I
G
D
S
I
F
D
K
-------
A
V
G
P
E
I
A
K
L
M
E
K
--
A
---
K
A
---
K
G
V
E
V
V
L
P
V
D
F
I
I
A
D
A
F
S
A
S
A
N
---
T
-
K
-
T
V
-
T
D
K
E
G
-
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
T
V
I
L
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
--
V
K
--
S
SA
A
--
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K