@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1811: (2015-12-10 )
MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPNMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGQFVKVSAEREPANIDWATDGVEIVLEATGFFASKEKAEQHIHENGAKKVVITAPGGNDVKTVVFNTNHDILDGTETVISGASCTTNCLAPMAKALQDNFGVKQGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGAAQRVPVPTGSVTELVATLEKDVTVEEVNAAMKAAANDSYGYTEDPIVSSDIVGISYGSLFDATQTKVQTVDGNQLVKVVSWYDNEMSYTSQLVRTLEYFAKIAK
Atome Classification :
(28 SA)
.........10........20..--..--.--...30.....-...40........50........60.-.......70........80........90........100.......110.......120.......130.....-..140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250-.-......260.....-----------..270---........280.......290.......300.---......310.......320.......330....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
V
K
VGINGF
G
R
I
G
R
L
A
F
R
R
IQN--VE--G--
V
E
V
T
R
INDLT-
D
P
N
M
L
A
H
L
L
KYDTTQGRFD
G
T
V
E
V
KE-G
G
F
E
VN
G
Q
F
V
K
V
SAEREPANIDWATD
G
V
E
I
V
L
EATGFFA
S
K
E
K
A
E
Q
H
I
H
ENGA
K
K
V
V
I
TAPGGN
D
V
K
T
V
V
FNTNH-DILDG
T
E
T
V
ISGASC
T
T
N
C
L
A
P
M
A
K
A
L
Q
DNFG
V
K
Q
G
L
M
T
T
I
HAYTGD
Q
M
I
LDGPHRGG
D
L
R
R
ARAGAANIVPNSTGA
A
K
A
I
G
L
V
IPELNGKLDGAAQRVPVPT
G
S
V
T
E
L
V
A
T
L
EK-D-V
T
V
E
E
V
N
A
A
M
K
AAA-----------NDSY----GYTEDPIVSS
D
I
V
G
I
SYGSLFDAT
Q
T
K
V
Q
TVD---GN
Q
L
V
K
V
V
S
WYDN
E
M
S
Y
T
S
Q
L
V
R
T
L
E
Y
F
A
K
IAK
23
PsiBlast_CBE
98.26
100%
-88
- C1 -
4QX6
2
?
B:
[22-356]
-
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
--
V
E
--
G
--
V
E
V
T
R
I
N
D
L
T
-
D
P
N
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
-
G
G
F
E
V
N
G
Q
F
V
K
V
S
A
E
R
E
P
A
N
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
S
K
E
K
A
E
Q
H
I
H
E
N
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
-
D
I
L
D
G
T
E
T
V
I
S
G
A
S
C
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
K
Q
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
A
A
Q
R
V
P
V
P
T
G
S
V
T
E
L
V
A
T
L
E
K
-
D
-
V
T
V
E
E
V
N
A
A
M
K
A
A
A
-----------
N
D
S
Y
----
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
I
S
Y
G
S
L
F
D
A
T
Q
T
K
V
Q
T
V
D
---
G
N
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
S
Q
L
V
R
T
L
E
Y
F
A
K
I
A
K
22
PsiBlast_CBE
97.95
100%
-88
- C1 -
4QX6
4
?
C:
[22-355]
-
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
--
V
E
--
G
--
V
E
V
T
R
I
N
D
L
T
-
D
P
N
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
-
G
G
F
E
V
N
G
Q
F
V
K
V
S
A
E
R
E
P
A
N
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
S
K
E
K
A
E
Q
H
I
H
E
N
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
-
D
I
L
D
G
T
E
T
V
I
S
G
A
S
C
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
K
Q
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
A
A
Q
R
V
P
V
P
T
G
S
V
T
E
L
V
A
T
L
E
K
-
D
-
V
T
V
E
E
V
N
A
A
M
K
A
A
A
-----------
N
D
S
Y
----
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
I
S
Y
G
S
L
F
D
A
T
Q
T
K
V
Q
T
V
D
---
G
N
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
S
Q
L
V
R
T
L
E
Y
F
A
K
I
A
-
21
PsiBlast_CBE
97.36
100%
-87
- C1 -
4QX6
3
?
D:
[21-356]
M
V
V
K
V
G
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
N
--
V
E
--
G
--
V
E
V
T
R
I
N
D
L
T
-
D
P
N
M
L
A
H
L
L
K
Y
D
T
T
Q
G
R
F
D
G
T
V
E
V
K
E
-
G
G
F
E
V
N
G
Q
F
V
K
V
S
A
E
R
E
P
A
N
I
D
W
A
T
D
G
V
E
I
V
L
E
A
T
G
F
F
A
S
K
E
K
A
E
Q
H
I
H
E
N
G
A
K
K
V
V
I
T
A
P
G
G
N
D
V
K
T
V
V
F
N
T
N
H
-
D
I
L
D
G
T
E
T
V
I
S
G
A
S
C
T
T
N
C
L
A
P
M
A
K
A
L
Q
D
N
F
G
V
K
Q
G
L
M
T
T
I
H
A
Y
T
G
D
Q
M
I
L
D
G
P
H
R
G
G
D
L
R
R
A
R
A
G
A
A
N
I
V
P
N
S
T
G
A
A
K
A
I
G
L
V
I
P
E
L
N
G
K
L
D
G
A
A
Q
R
V
P
V
P
T
G
S
V
T
E
L
V
A
T
L
E
K
-
D
-
V
T
V
E
E
V
N
A
A
M
K
A
A
A
-----------
N
D
S
Y
----
G
Y
T
E
D
P
I
V
S
S
D
I
V
G
I
S
Y
G
S
L
F
D
A
T
Q
T
K
V
Q
T
V
D
---
G
N
Q
L
V
K
V
V
S
W
Y
D
N
E
M
S
Y
T
S
Q
L
V
R
T
L
E
Y
F
A
K
I
A
K
38
PsiBlast_CBE
85.61
68%
-81
- C1 -
3LVF
2
G3P1_STAAR
R:
[4-338]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
44
PsiBlast_CBE
85.48
68%
-83
- C1 -
3LC1
3
G3P1_STAAR
O:
[2-335]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
59
PsiBlast_CBE
84.98
68%
-81
- C1 -
3KSZ
3
G3P1_STAAR
P:
[2-335]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
55
PsiBlast_CBE
84.78
68%
-80
- C1 -
3K9Q
3
G3P1_STAAR
P:
[1-335]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
G
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
40
PsiBlast_CBE
84.60
68%
-81
- C1 -
3LVF
2
G3P1_STAAR
O:
[4-337]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
7
PsiBlast_PDB
84.57
68%
-81
- C1 -
3LC1
3
G3P1_STAAR
P:
[1-336]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
4
PsiBlast_PDB
84.52
68%
-79
- C1 -
3LVF
2
G3P1_STAAR
P:
[3-338]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
42
PsiBlast_CBE
84.50
68%
-81
- C1 -
3LC1
2
G3P1_STAAR
R:
[1-336]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
58
PsiBlast_CBE
84.48
68%
-81
- C1 -
3KSZ
3
G3P1_STAAR
Q:
[2-334]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
2
PsiBlast_PDB
84.41
68%
-78
- C1 -
3L6O
1
G3P1_STAAR
Q:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
49
PsiBlast_CBE
84.37
68%
-80
- C1 -
3HQ4
2
G3P1_STAAR
P:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
56
PsiBlast_CBE
84.36
68%
-80
- C1 -
3K9Q
4
G3P1_STAAR
O:
[1-335]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
G
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
30
PsiBlast_CBE
84.35
68%
-78
- C1 -
3K73
4
G3P1_STAAR
R:
[1-336]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
34
PsiBlast_CBE
84.34
68%
-80
- C1 -
3VAZ
3
G3P1_STAAR
Q:
[10-342]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
8
PsiBlast_PDB
84.26
68%
-82
- C1 -
3HQ4
2
G3P1_STAAR
R:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
110
HHSearch
84.22
69%
-77
- C1 -
3LVF
2
G3P1_STAAR
P:
[3-338]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
-
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
-
S
E
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
---
V
M
SVG
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
10
PsiBlast_PDB
84.18
68%
-81
- C1 -
3K9Q
3
G3P1_STAAR
Q:
[1-335]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
--
V
E
--
G
--
L
E
V
V
A
V
N
D
L
T
-
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
-
G
G
F
R
V
N
G
K
E
V
K
S
F
S
E
P
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
-
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
-
Q
E
L
D
G
S
E
T
V
V
S
G
A
S
G
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
-----------
N
E
S
F
----
G
Y
T
E
D
E
I
V
S
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
---
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
106
HHSearch
77.68
54%
-75
- C1 -
1HDG
3
G3P_THEMA
O:
[1-332]
--
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
RK
N
P
--
D
--
I
E
V
V
A
I
N
D
L
T
-
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
T
E
-
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
-
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
K
--
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
EGRL-------
K
G
I
I
----
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
---
V
I
---
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--
103
HHSearch
77.44
46%
-76
- C1 -
1RM4
3
G3PA_SPIOL
O:
[1-336]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
--
R
K
DS
P
--
L
D
V
V
V
I
N
D
T
G
-
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
R
--
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
DNEL-------
K
G
I
L
----
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
---
V
M
---
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
Q
17
PsiBlast_PDB
77.03
52%
-74
- C1 -
1HDG
3
G3P_THEMA
O:
[2-332]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
--
R
K
--
N
PD
I
E
V
V
A
I
N
D
L
T
-
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
T
E
-
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
-
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
-
D
Q
L
K
P
E
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
K
--
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
-----------
E
G
R
L
KGII
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
------
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--
112
HHSearch
76.06
53%
-72
- C1 -
2EP7
1
G3P_AQUAE
A:
[3-340]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
--
R
E
--
E
--
I
E
I
V
A
I
N
D
L
T
-
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
V
E
A
K
D
-
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
-
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
K
--
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
-
A
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGKVYL
K
E
I
L
----
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
---
V
----
I
D
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
--
72
PsiBlast_CBE
75.67
52%
-75
- C1 -
1HDG
3
G3P_THEMA
Q:
[2-332]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
--
R
K
--
N
PD
I
E
V
V
A
I
N
D
L
T
-
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
T
E
-
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
-
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
-
D
Q
L
K
P
E
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
K
--
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
-----------
E
G
R
L
KGII
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
------
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--
111
HHSearch
75.18
46%
-77
- C1 -
3PYM
3
G3P3_YEAST
A:
[1-331]
-
M
V
R
V
A
I
N
G
F
G
R
I
G
R
L
V
M
R
I
A
L
S
--
R
P
--
N
--
V
E
V
V
A
L
N
D
P
F
I
T
N
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
R
Y
A
G
E
V
S
H
D
D
-
K
H
I
I
V
D
G
K
K
I
A
T
Y
Q
E
R
D
P
A
N
L
P
W
G
S
S
N
V
D
I
A
I
D
S
T
G
V
F
K
E
L
D
T
A
Q
K
H
I
D
A
-
G
A
K
K
V
V
I
T
A
P
S
S
-
T
A
P
M
F
V
M
G
V
N
E
E
K
Y
T
S
-
D
L
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
A
F
G
I
E
E
G
L
M
T
T
V
H
S
L
T
A
T
Q
K
T
V
D
G
P
S
H
-
K
D
W
R
G
G
R
T
A
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
V
D
V
S
V
V
D
L
T
V
K
L
N
K
-
E
-
T
T
Y
D
E
I
K
K
V
V
K
A
A
A
E
G
KL-------
K
G
V
L
----
G
Y
T
E
D
A
V
V
S
S
D
F
L
G
D
S
H
S
S
I
F
D
A
S
A
G
I
---
Q
L
---
S
P
K
F
V
K
L
V
S
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
K
A
--
108
HHSearch
74.52
47%
-78
- C1 -
3CPS
1
?
A:
[18-353]
--
G
T
L
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
--
R
N
--
D
--
I
T
V
V
A
I
N
D
P
F
M
D
V
E
Y
M
A
Y
L
L
K
Y
D
S
V
H
G
N
F
N
G
T
V
E
V
S
G
--
D
L
C
I
N
G
K
V
V
K
V
F
Q
A
K
D
P
A
E
I
P
W
G
A
S
G
A
Q
I
V
C
E
S
T
G
V
F
T
T
E
E
K
A
S
L
H
L
K
G
-
G
A
K
K
V
I
I
S
A
P
P
K
D
N
V
P
M
Y
V
M
G
V
N
N
T
E
Y
D
P
S
K
F
N
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
P
S
K
G
-
D
W
R
A
G
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
R
V
P
T
P
D
V
S
V
V
D
L
T
C
K
L
A
K
-
P
-
A
S
I
E
E
I
Y
Q
A
V
K
E
A
S
N
GPM-------
K
G
I
M
----
G
Y
T
S
D
D
V
V
S
T
D
F
I
G
C
K
Y
S
S
I
F
D
K
N
A
C
I
---
A
L
---
N
D
S
F
V
K
L
I
S
W
Y
D
N
E
S
G
Y
S
N
R
L
V
D
L
A
V
Y
V
A
S
R
G
L
115
HHSearch
71.86
44%
-73
- C1 -
3H9E
10
G3PT_HUMAN
O:
[6-339]
R
E
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
--
K
---
G
--
V
K
V
V
A
V
N
D
P
F
I
D
P
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
R
Y
K
G
S
V
E
F
R
N
-
G
Q
L
V
V
D
N
H
E
I
S
V
Y
Q
C
K
E
P
K
Q
I
P
W
R
A
V
G
S
P
Y
V
V
E
S
T
G
V
Y
L
S
I
Q
A
A
S
D
H
I
S
A
-
G
A
Q
R
V
V
I
S
A
P
S
P
-
D
A
P
M
F
V
M
G
V
N
E
N
D
Y
N
P
G
S
M
N
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
E
R
F
G
I
V
E
G
L
M
T
T
V
H
S
Y
T
A
T
Q
K
T
V
D
G
P
S
R
-
K
A
W
R
D
G
R
G
A
H
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
T
K
V
I
P
E
L
K
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
C
R
L
A
Q
-
P
-
A
P
Y
S
A
I
K
E
A
V
K
A
A
A
KGPM-------
A
G
I
L
----
A
Y
T
E
D
E
V
V
S
T
D
F
L
G
D
T
H
S
S
I
F
D
A
K
A
G
I
---
A
L
---
N
D
N
F
V
K
L
I
S
W
Y
D
N
E
Y
G
Y
S
H
R
V
V
D
L
L
R
Y
M
F
S
R
D
A