@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1812: (2015-12-10 )
MAREFSLEKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWDGHRVNIIDTPGHVDFTIEVQRSLRVLDGAVTVLDAQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVQSLHDRLQANAHPIQLPIGSEDDFRGIIDLIKMKAEIYTNDLGTDILEEDIPAEYVDQANEYREKLVEAVADTDEDLMMKYLEGEEITNEELMAAIRRATINVEFYPVLCGSAFKNKGVQLMLDAVIDYLPSPLDIPAIKGINPDTDEEETRPASDEEPFAALAFKIMTDPFVGRLTFFRVYSGVLNSGSYVLNTSKGKRERIGRILQMHANSRQEIETVYAGDIAAAVGLKDTTTGDSLTDEKSKVILESIEVPEPVIQLMVEPKSKADQDKMGIALQKLAEEDPTFRVETNVETGETVISGMGELHLDVLVDRMKREFKVEANVGAPQVSYRETFRASTQARGFFKRQSGGKGQFGDVWIEFTPNEEGKGFEFENAIVGGVVPREFIPAVEKGLVESMANGVLAGYPMVDVKAKLYDGSYHDVDSSETAFKIAASLALKEAAKSAQPAILEPMMLVTITAPEDNLGDVMGHVTARRGRVDGMEARGNTQVVRAFVPLAEMFGYATVLRSATQGRGTFMMVFDHYEDVPKSVQEEIIKKNSGE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70..-----.-------.....80........90........100.......110.......120.......130.......140.......150.......160.......170.......180......-.190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.-......-300.......310.......320.......330.......340.......350.......360.......370....----...380.......390.-.--.....400.-----......410.......420.......430.......440..---.....450.......460.......470.......480......-.490.......500.......510......---.520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650........660.......670.......680.......690
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAREFSLEKTRNI
G
I
M
A
H
VDAGKTTT
T
E
R
I
L
Y
YT
G
K
I
H
KIGETHEG
A
S
Q
M
D
W
M
E
Q
E
Q
ER
G
I
T
I
T
S
A
A
T
T
AQWD-----G-------
H
R
V
N
I
I
DTPG
H
V
D
F
T
I
E
V
Q
RS
L
R
VLD
G
A
V
T
V
L
DAQSGVEP
Q
T
E
T
V
W
R
Q
A
T
EYGV
P
R
I
V
FAN
K
M
D
K
I
G
A
D
F
L
Y
S
V
Q
S
L
H
D
R
L
QANA
H
P
I
QLPIGSE
D
D
F
R
G
I
I
D
L
I
K
M
K
A
E
IYTN-DL
G
T
D
I
L
E
EDI
P
A
E
Y
V
D
Q
A
N
E
Y
R
E
K
L
V
E
A
V
ADT
D
E
D
L
M
M
K
Y
LEGEEI
T
N
E
E
L
M
A
A
I
R
R
A
T
I
N
V
E
F
Y
PVLCG
S
A
FKNK
G
V
Q
L
M
L
D
A
V
I
D
YLPSPLDIPAIKGINPD-TDEEET-RPASDEE
P
F
A
A
L
A
F
KIMTDP
F
V
G
R
L
T
F
F
R
V
Y
S
G
V
LNSG
S
Y
V
L
NTSKG
K
R
E
R
I
G
R
I
L
Q
M
HANS
R
Q
E
I
E
T
VYAG
D
I
A
A
A----VGLKDTTTGDSLT
D
E
K
S
-
K
--
V
I
L
E
SIEV
P
-----
E
P
V
I
Q
L
MVEPKSKA
D
Q
D
K
M
G
I
A
L
Q
K
L
AEEDP
T
F
R
V
E
TNVET---
G
E
T
V
I
S
G
M
G
E
L
H
L
D
V
L
V
D
R
M
K
R
E
F
K
V
E
ANVGAPQ
V
S
Y
R
E
T
F
RA
S
-
T
QAR
G
F
F
KRQSGGKGQF
G
D
V
W
I
E
FTPNEEG---KGFEFENAIVGGV
V
P
R
E
F
I
P
A
V
E
K
G
L
V
E
S
M
ANGVLAGY
P
M
V
D
V
K
A
K
LYDGSYHDVDSSE
T
A
F
K
I
A
A
S
L
A
L
K
E
A
A
KSAQPAILE
P
M
M
L
V
T
I
TAPED
N
L
G
D
V
M
G
H
V
T
ARRGRVDGMEARGN
T
Q
V
V
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
V
L
R
S
ATQGR
G
T
F
M
M
V
F
D
H
Y
E
D
V
P
K
S
V
Q
E
E
I
I
KKNSGE
21
PsiBlast_CBE
89.84
76%
-14
- C- -
2XEX
2
EFG_STAAU
B:
[2-693]
-
A
R
E
F
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
G
----
G
A
S
Q
M
D
W
M
E
Q
E
--------
S
A
A
T
T
A
A
W
E
-----
G
-------
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
P
R
I
V
F
V
N
K
M
D
K
L
G
A
N
F
E
Y
S
V
S
T
L
H
D
R
L
Q
A
N
A
A
P
I
Q
L
P
I
G
A
E
D
E
F
E
A
I
I
D
L
V
E
M
K
C
F
K
Y
T
N
-
D
L
G
T
E
I
E
E
I
E
I
P
E
D
H
L
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
L
G
D
E
E
I
S
V
S
E
L
K
E
A
I
R
Q
A
T
T
N
V
E
F
Y
P
V
L
C
G
T
A
F
K
N
K
G
V
Q
L
M
L
D
A
V
I
D
Y
L
P
S
P
L
D
V
K
P
I
I
G
H
R
A
S
-
N
P
E
E
E
V
I
A
K
A
D
D
S
A
E
F
A
A
L
A
F
K
V
M
T
D
P
Y
V
G
K
L
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
K
N
S
T
K
G
K
R
E
R
V
G
R
L
L
Q
M
H
A
N
S
R
Q
E
I
D
T
V
Y
S
G
D
I
A
A
A
----
V
G
L
K
D
T
G
T
G
D
T
L
C
G
E
K
N
-
D
--
I
I
L
E
S
M
E
F
P
-----
E
P
V
I
H
L
S
V
E
P
K
S
K
A
D
Q
D
K
M
T
Q
A
L
V
K
L
Q
E
E
D
P
T
F
H
A
H
T
--------
Q
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F
N
V
E
C
N
V
G
A
P
M
V
S
Y
R
E
T
F
K
S
S
-
A
Q
V
Q
G
K
F
S
R
Q
S
G
G
R
G
Q
Y
G
D
V
H
I
E
F
T
P
N
E
T
G
---
A
G
F
E
F
E
N
A
I
V
G
G
V
V
P
R
E
Y
I
P
S
V
E
A
G
L
K
D
A
M
E
N
G
V
L
A
G
Y
P
L
I
D
V
K
A
K
L
Y
D
G
S
Y
H
D
V
D
S
S
E
M
A
F
K
I
A
A
S
L
A
L
K
E
A
A
K
K
C
D
P
V
I
L
E
P
M
M
K
V
T
I
E
M
P
E
E
Y
M
G
D
I
M
G
D
V
T
S
R
R
G
R
V
D
G
M
E
P
R
G
N
A
Q
V
V
N
A
Y
V
P
L
S
E
M
-
F
G
Y
A
T
S
L
R
S
N
T
Q
G
R
G
T
Y
T
M
Y
F
D
H
Y
A
E
V
P
K
S
I
A
E
D
I
I
K
K
N
K
G
E
1
PsiBlast_PDB
88.87
76%
-13
- C- -
2XEX
2
EFG_STAAU
A:
[2-693]
-
A
R
E
F
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
-------------------------
T
S
A
A
T
T
A
A
W
E
-----
G
-------
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
P
R
I
V
F
V
N
K
M
D
K
L
G
A
N
F
E
Y
S
V
S
T
L
H
D
R
L
Q
A
N
A
A
P
I
Q
L
P
I
G
A
E
D
E
F
E
A
I
I
D
L
V
E
M
K
C
F
K
Y
T
N
-
D
L
G
T
E
I
E
E
I
E
I
P
E
D
H
L
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
L
G
D
E
E
I
S
V
S
E
L
K
E
A
I
R
Q
A
T
T
N
V
E
F
Y
P
V
L
C
G
T
A
F
K
N
K
G
V
Q
L
M
L
D
A
V
I
D
Y
L
P
S
P
L
D
V
K
P
I
I
G
H
R
A
S
-
N
P
E
E
E
V
I
A
K
A
D
D
S
A
E
F
A
A
L
A
F
K
V
M
T
D
P
Y
V
G
K
L
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
K
N
S
T
K
G
K
R
E
R
V
G
R
L
L
Q
M
H
A
N
S
R
Q
E
I
D
T
V
Y
S
G
D
I
A
A
A
----
V
G
L
K
D
T
G
T
G
D
T
L
C
G
E
K
N
-
D
--
I
I
L
E
S
M
E
F
P
-----
E
P
V
I
H
L
S
V
E
P
K
S
K
A
D
Q
D
K
M
T
Q
A
L
V
K
L
Q
E
E
D
P
T
F
H
A
H
T
---
T
---
G
Q
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F
N
V
E
C
N
V
G
A
P
M
V
S
Y
R
E
T
F
K
S
S
-
A
Q
V
Q
G
K
F
S
R
Q
S
G
G
R
G
Q
Y
G
D
V
H
I
E
F
T
P
N
E
T
G
---
A
G
F
E
F
E
N
A
I
V
G
G
V
V
P
R
E
Y
I
P
S
V
E
A
G
L
K
D
A
M
E
N
G
V
L
A
G
Y
P
L
I
D
V
K
A
K
L
Y
D
G
S
Y
H
D
V
D
S
S
E
M
A
F
K
I
A
A
S
L
A
L
K
E
A
A
K
K
C
D
P
V
I
L
E
P
M
M
K
V
T
I
E
M
P
E
E
Y
M
G
D
I
M
G
D
V
T
S
R
R
G
R
V
D
G
M
E
P
R
G
N
A
Q
V
V
N
A
Y
V
P
L
S
E
M
-
F
G
Y
A
T
S
L
R
S
N
T
Q
G
R
G
T
Y
T
M
Y
F
D
H
Y
A
E
V
P
K
S
I
A
E
D
I
I
K
K
N
K
G
E
105
HHSearch
88.73
76%
-12
- C- -
2XEX
2
EFG_STAAU
A:
[2-693]
-
A
R
E
F
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
-------------------------
T
S
A
A
T
T
A
A
W
E
-----
G
-------
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
P
R
I
V
F
V
N
K
M
D
K
L
G
A
N
F
E
Y
S
V
S
T
L
H
D
R
L
Q
A
N
A
A
P
I
Q
L
P
I
G
A
E
D
E
F
E
A
I
I
D
L
V
E
M
K
C
F
K
Y
T
N
-
D
L
G
T
E
I
E
E
I
E
I
P
E
D
H
L
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
L
G
D
E
E
I
S
V
S
E
L
K
E
A
I
R
Q
A
T
T
N
V
E
F
Y
P
V
L
C
G
T
A
F
K
N
K
G
V
Q
L
M
L
D
A
V
I
D
Y
L
P
S
P
L
D
V
K
P
I
I
G
H
R
A
S
N
P
E
E
E
V
I
-
A
K
A
D
D
S
A
E
F
A
A
L
A
F
K
V
M
T
D
P
Y
V
G
K
L
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
K
N
S
T
K
G
K
R
E
R
V
G
R
L
L
Q
M
H
A
N
S
R
Q
E
I
D
T
V
Y
S
G
D
I
A
A
A
----
V
G
L
K
D
T
G
T
G
D
T
L
C
G
E
K
N
-
D
--
I
I
L
E
S
M
E
F
P
-----
E
P
V
I
H
L
S
V
E
P
K
S
K
A
D
Q
D
K
M
T
Q
A
L
V
K
L
Q
E
E
D
P
T
F
H
A
H
T
---
T
---
G
Q
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F
N
V
E
C
N
V
G
A
P
M
V
S
Y
R
E
T
F
K
S
S
-
A
Q
V
Q
G
K
F
S
R
Q
S
G
G
R
G
Q
Y
G
D
V
H
I
E
F
T
P
N
E
T
G
---
A
G
F
E
F
E
N
A
I
V
G
G
V
V
P
R
E
Y
I
P
S
V
E
A
G
L
K
D
A
M
E
N
G
V
L
A
G
Y
P
L
I
D
V
K
A
K
L
Y
D
G
S
Y
H
D
V
D
S
S
E
M
A
F
K
I
A
A
S
L
A
L
K
E
A
A
K
K
C
D
P
V
I
L
E
P
M
M
K
V
T
I
E
M
P
E
E
Y
M
G
D
I
M
G
D
V
T
S
R
R
G
R
V
D
G
M
E
P
R
G
N
A
Q
V
V
N
A
Y
V
P
L
S
E
M
-
F
G
Y
A
T
S
L
R
S
N
T
Q
G
R
G
T
Y
T
M
Y
F
D
H
Y
A
E
V
P
K
S
I
A
E
D
I
I
K
K
N
K
G
E
3
PsiBlast_PDB
87.78
65%
-80
- C2 -
2J7K
2
EFG_THETH
A:
[6-688]
---
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
------------------------
I
T
A
A
V
T
T
C
F
W
K
-----
D
-------
H
R
I
N
I
I
D
A
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
-
G
E
V
V
E
I
-
H
P
D
P
N
-
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
--
V
I
L
E
S
I
E
V
P
-----
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
---
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
-
V
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
---
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
------
12
PsiBlast_PDB
87.66
65%
-81
- C2 -
2BM0
2
?
A:
[6-689]
---
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
A
--------------------
T
I
T
A
A
V
T
T
C
F
W
K
-----
D
-------
H
R
I
N
I
I
D
A
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
-
G
E
V
V
E
I
-
H
P
D
P
N
-
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
--
V
I
L
E
S
I
E
V
P
-----
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
---
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
-
V
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
---
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
K
-----
10
PsiBlast_PDB
87.44
65%
-79
- C2 -
1FNM
2
EFG_THETH
A:
[6-688]
---
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
----------------------------
A
V
T
T
C
F
W
K
-----
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
-
G
E
V
V
E
I
-
H
P
D
P
N
-
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
--
V
I
L
E
S
I
E
V
P
-----
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
---
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
-
V
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
---
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
A
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
------
131
Fugue
87.23
65%
-82
- C2 -
4M1K
2
?
A:
[6-688]
---
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
---------------------------
A
A
V
T
T
C
F
W
K
-----
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
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A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
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E
E
P
T
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E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
-
G
E
V
V
E
I
-
H
P
-
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
--
V
I
L
E
S
I
E
V
P
-----
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
---
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
-
V
D
V
E
G
K
F
I
R
L
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
---
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
------
7
PsiBlast_PDB
86.82
65%
-83
- C2 -
4M1K
2
?
A:
[6-688]
---
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
---------------------------
A
A
V
T
T
C
F
W
K
-----
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
-
G
E
V
V
E
I
-
H
P
D
P
N
-
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
--
V
I
L
E
S
I
E
V
P
-----
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
---
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
-
V
D
V
E
G
K
F
I
R
L
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
---
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
------
9
PsiBlast_PDB
86.77
65%
-80
- C2 -
4MYU
2
EFG_THETH
A:
[6-688]
---
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
----------------------------
A
V
T
T
C
F
W
K
-----
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
-
G
E
V
V
E
I
-
H
P
D
P
N
-
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
--
V
I
L
E
S
I
E
V
P
-----
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
---
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
-
V
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
---
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
K
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
------
2
PsiBlast_PDB
86.67
65%
-78
- C2 -
2OM7
-
?
L:
[6-688]
---
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
----------------------------
A
V
T
T
C
F
W
K
-----
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
-
G
E
V
V
E
I
-
H
P
D
P
N
-
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
--
V
I
L
E
S
I
E
V
P
-----
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
---
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
-
V
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
---
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
------
5
PsiBlast_PDB
85.42
65%
-76
- C2 -
2EFG
1
EFG_THET8
A:
[7-689]
----
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
---------------------------
A
A
V
T
T
C
F
W
K
-----
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
N
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
-
G
E
V
V
E
I
-
H
P
D
P
N
-
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
--
V
I
L
E
S
----------------------------------------------------------------------------------
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
-
V
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
---
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
K
-----
8
PsiBlast_PDB
85.29
65%
-81
- C2 -
2BM1
2
EFG_THETH
A:
[6-688]
---
E
Y
D
L
K
R
L
R
N
I
V
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
-------------------------
I
T
A
A
V
T
T
C
F
W
K
-----
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
-
G
E
V
V
E
I
-
H
P
D
P
N
-
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
--
V
I
L
E
S
I
E
V
P
-----
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
---
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
-
V
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
---
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
------
4
PsiBlast_PDB
84.12
65%
-74
- C2 -
4MYT
2
EFG_THETH
A:
[6-688]
---
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
---------------------------
A
A
V
T
T
C
F
W
K
-----
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
G
R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
G
T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
I
T
P
V
F
L
G
S
A
L
K
N
K
G
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
I
P
P
I
K
G
T
T
P
E
-
G
E
V
V
E
I
-
H
P
D
P
N
-
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
T
K
G
R
K
E
R
V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
--
V
I
L
E
S
I
E
V
P
-----
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
---
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
-
V
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
---
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
A
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
------
13
PsiBlast_PDB
81.95
65%
-65
- C2 -
3IZP
-
?
E:
[6-688]
---
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
G
E
V
H
E
G
A
A
T
M
D
F
M
E
Q
E
R
E
R
G
I
T
I
T
A
A
V
T
T
C
F
W
K
-----
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
L
W
L
V
I
R
T
M
Q
E
R
L
G
A
R
P
V
V
M
Q
L
P
I
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R
E
D
T
F
S
G
I
I
D
V
L
R
M
K
A
Y
T
Y
G
N
-
D
L
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T
D
I
R
E
I
P
I
P
E
E
Y
L
D
Q
A
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L
V
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V
A
A
D
F
D
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N
I
M
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Y
L
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E
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T
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E
E
L
V
A
A
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I
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F
L
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A
L
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N
K
G
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Q
L
L
L
D
A
V
V
D
Y
L
P
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P
L
D
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P
P
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-
G
E
V
V
E
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-
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N
-
G
P
L
A
A
L
A
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M
A
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Y
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G
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L
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G
T
L
T
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G
S
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Y
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T
T
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G
R
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E
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V
A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
P
R
--
V
I
L
E
S
I
E
V
P
-----
E
P
V
I
D
V
A
I
E
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
---
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
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F
K
V
D
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
-
V
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
---
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
A
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
------
133
Fugue
80.27
63%
-75
- C2 -
1ELO
-
?
?:
[5-689]
--
V
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
----------------------------
A
V
T
T
C
F
W
K
-----
D
-------
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
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A
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A
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A
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N
-
D
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A
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A
A
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A
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L
L
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A
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V
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Y
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P
P
I
K
G
T
T
P
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--
G
E
V
V
E
-
I
H
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D
P
N
G
P
L
A
A
L
A
F
K
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A
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Y
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Y
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G
T
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T
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Y
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A
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
-
P
--
R
V
I
L
-------------
I
D
V
A
I
E
P
K
S
Q
A
--------
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
------
P
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
-----
V
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
-
V
D
V
E
G
K
F
I
R
Q
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
---
S
G
F
E
F
V
N
A
I
V
G
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
Q
I
L
G
M
E
P
R
G
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
K
-----
15
PsiBlast_PDB
79.37
60%
-66
- C2 -
3J0E
2
EFG_ECOLI
H:
[1-699]
-
A
R
T
T
P
I
A
R
Y
R
N
I
G
I
S
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
F
Y
T
G
V
N
H
K
I
G
E
V
H
D
G
A
A
T
M
D
W
M
E
Q
E
Q
E
R
G
I
T
I
T
S
A
A
T
T
A
F
W
S
-----
G
MAKQYEP
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
V
M
V
Y
C
A
V
G
G
V
Q
P
Q
S
E
T
V
W
R
Q
A
N
K
Y
K
V
P
R
I
A
F
V
N
K
M
D
R
M
G
A
N
F
L
K
V
V
N
Q
I
K
T
R
L
G
A
N
P
V
P
L
Q
L
A
I
G
A
E
E
H
F
T
G
V
V
D
L
V
K
M
K
A
I
N
W
N
D
A
D
Q
G
V
T
F
E
Y
E
D
I
P
A
D
M
V
E
L
A
N
E
W
H
Q
N
L
I
E
S
A
A
E
A
S
E
E
L
M
E
K
Y
L
G
G
E
E
L
T
E
A
E
I
K
G
A
L
R
Q
R
V
L
N
N
E
I
I
L
V
T
C
G
S
A
F
K
N
K
G
V
Q
A
M
L
D
A
V
I
D
Y
L
P
S
P
V
D
V
P
A
I
N
G
I
L
D
D
G
K
D
T
P
A
E
-
R
H
A
S
D
D
E
P
F
S
A
L
A
F
K
I
A
T
D
P
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V
G
N
L
T
F
F
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V
Y
S
G
V
V
N
S
G
D
T
V
L
N
S
V
K
A
A
R
E
R
F
G
R
I
V
Q
M
H
A
N
K
R
E
E
I
K
E
V
R
A
G
D
I
A
A
A
----
I
G
L
K
D
V
T
T
G
D
T
L
C
D
P
D
A
-
P
--
I
I
L
E
R
M
E
F
P
-----
E
P
V
I
S
I
A
V
E
P
K
T
K
A
D
Q
E
K
M
G
L
A
L
G
R
L
A
K
E
D
P
S
F
R
V
W
T
D
E
E
S
---
N
Q
T
I
I
A
G
M
G
E
L
H
L
D
I
I
V
D
R
M
K
R
E
F
N
V
E
A
N
V
G
K
P
Q
V
A
Y
R
E
T
I
R
Q
K
V
T
D
V
E
G
K
H
A
K
Q
S
G
G
R
G
Q
Y
G
H
V
V
I
D
M
Y
P
L
E
P
G
SNP
K
G
Y
E
F
I
N
D
I
K
G
G
V
I
P
G
E
Y
I
P
A
V
D
K
G
I
Q
E
Q
L
K
A
G
P
L
A
G
Y
P
V
V
D
M
G
I
R
L
H
F
G
S
Y
H
D
V
D
S
S
E
L
A
F
K
L
A
A
S
I
A
F
K
E
G
F
K
K
A
K
P
V
L
L
E
P
I
M
K
V
E
V
E
T
P
E
E
N
T
G
D
V
I
G
D
L
S
R
R
R
G
M
L
K
G
Q
E
S
E
V
T
G
V
K
I
H
A
E
V
P
L
S
E
M
-
F
G
Y
A
T
Q
L
R
S
L
T
K
G
R
A
S
Y
T
M
E
F
L
K
Y
D
E
A
P
S
N
V
A
Q
A
V
I
E
A
R
G
--
16
PsiBlast_PDB
74.62
35%
-65
- C2 -
1WDT
2
?
A:
[10-664]
----------
R
T
V
A
L
V
G
H
A
G
S
G
K
T
T
L
T
E
A
L
L
Y
K
T
G
A
K
E
R
R
G
R
V
E
E
G
T
T
T
T
D
Y
T
P
E
A
K
L
H
R
T
T
V
R
T
G
V
A
P
L
L
F
R
-----
G
-------
H
R
V
F
L
L
D
A
P
G
Y
G
D
F
V
G
E
I
R
G
A
L
E
A
A
D
A
A
L
V
A
V
S
A
E
A
G
V
Q
V
G
T
E
R
A
W
T
V
A
E
R
L
G
L
P
R
M
V
V
V
T
K
L
D
K
-
G
G
D
Y
Y
A
L
L
E
D
L
R
S
T
L
-
G
P
I
L
P
I
D
L
P
L
Y
E
G
G
K
W
V
G
L
I
D
V
F
H
G
K
A
Y
R
Y
E
N
-
G
---
E
E
R
E
A
E
V
P
P
E
E
R
E
R
V
Q
R
F
R
Q
E
V
L
E
A
I
V
E
T
D
E
G
L
L
E
K
Y
L
E
G
E
E
V
T
G
E
A
L
E
K
A
F
H
E
A
V
R
R
G
L
L
Y
P
V
A
L
A
S
G
E
R
E
I
G
V
L
P
L
L
E
L
I
L
E
A
L
P
S
P
------------------
T
-
E
R
F
G
D
G
P
P
L
A
K
V
-
F
K
V
Q
V
D
P
F
M
G
Q
V
A
Y
L
R
L
Y
R
G
R
L
K
P
G
D
S
L
--
Q
S
E
A
G
Q
V
R
L
P
H
L
Y
V
P
M
G
K
D
L
L
E
V
E
E
A
E
A
G
F
V
L
G
V
----
P
K
A
E
G
L
H
R
G
M
V
L
W
Q
G
E
K
-
P
-----
E
S
E
E
V
P
F
A
R
L
P
D
P
N
V
P
V
A
L
H
P
K
G
R
T
D
E
A
R
L
G
E
A
L
R
K
L
L
E
E
D
P
S
L
K
L
E
R
Q
E
E
T
---
G
E
L
L
L
W
G
H
G
E
L
H
L
A
T
A
K
E
R
L
Q
-
D
Y
G
V
E
V
E
F
S
V
P
K
V
P
Y
R
E
T
I
K
K
V
-
A
E
G
Q
G
K
Y
K
K
Q
T
G
G
H
G
Q
Y
G
D
V
W
L
R
L
E
P
A
S
E
------
Y
G
F
E
W
R
I
T
G
G
V
I
P
S
K
Y
Q
E
A
I
E
E
G
I
K
E
A
A
K
K
G
V
L
A
G
F
P
V
M
G
F
K
A
I
V
Y
N
G
S
Y
H
E
V
D
S
S
D
L
A
F
Q
I
A
A
S
L
A
F
K
K
V
M
A
E
A
H
P
V
L
L
E
P
I
Y
R
L
K
V
L
A
P
Q
E
R
V
G
D
V
L
S
D
L
Q
A
R
R
G
R
I
L
G
M
E
Q
E
G
A
L
S
V
V
H
A
E
V
P
L
A
E
V
-
L
E
Y
Y
K
A
L
P
G
L
T
G
G
A
G
A
Y
T
L
E
F
S
H
Y
A
E
V
P
P
H
L
A
Q
R
I
V
Q
E
R
A
Q
E
17
PsiBlast_PDB
73.70
35%
-67
- C2 -
2DY1
2
?
A:
[10-664]
----------
R
T
V
A
L
V
G
H
A
G
S
G
K
T
T
L
T
E
A
L
L
Y
K
T
G
A
K
E
R
R
G
R
V
E
E
G
T
T
T
T
D
Y
T
P
E
A
K
L
H
R
T
T
V
R
T
G
V
A
P
L
L
F
R
-----
G
-------
H
R
V
F
L
L
D
A
P
G
Y
G
D
F
V
G
E
I
R
G
A
L
E
A
A
D
A
A
L
V
A
V
S
A
E
A
G
V
Q
V
G
T
E
R
A
W
T
V
A
E
R
L
G
L
P
R
M
V
V
V
T
K
L
D
K
-
G
G
D
Y
Y
A
L
L
E
D
L
R
S
T
L
-
G
P
I
L
P
I
D
L
P
L
Y
E
G
G
K
W
V
G
L
I
D
V
F
H
G
K
A
Y
R
Y
E
N
-
G
---
E
E
R
E
A
E
V
P
P
E
E
R
E
R
V
Q
R
F
R
Q
E
V
L
E
A
I
V
E
T
D
E
G
L
L
E
K
Y
L
E
G
E
E
V
T
G
E
A
L
E
K
A
F
H
E
A
V
R
R
G
L
L
Y
P
V
A
L
A
S
G
E
R
E
I
G
V
L
P
L
L
E
L
I
L
E
A
L
P
S
P
------------------
T
-
E
R
F
G
D
G
P
P
L
A
K
V
-
F
K
V
Q
V
D
P
F
M
G
Q
V
A
Y
L
R
L
Y
R
G
R
L
K
P
G
D
S
L
--
Q
S
E
A
G
Q
V
R
L
P
H
L
Y
V
P
M
G
K
D
L
L
E
V
E
E
A
E
A
G
F
V
L
G
V
----
P
K
A
E
G
L
H
R
G
M
V
L
W
Q
G
E
K
-
P
-----
E
S
E
E
V
P
F
A
R
L
P
D
P
N
V
P
V
A
L
H
P
K
G
R
T
D
E
A
R
L
G
E
A
L
R
K
L
L
E
E
D
P
S
L
K
L
E
R
Q
E
E
T
---
G
E
L
L
L
W
G
H
G
E
L
H
L
A
T
A
K
E
R
L
Q
-
D
Y
G
V
E
V
E
F
S
V
P
K
V
P
Y
R
E
T
I
K
K
V
-
A
E
G
Q
G
K
Y
K
K
Q
T
G
G
H
G
Q
Y
G
D
V
W
L
R
L
E
P
A
S
E
------
Y
G
F
E
W
R
I
T
G
G
V
I
P
S
K
Y
Q
E
A
I
E
E
G
I
K
E
A
A
K
K
G
V
L
A
G
F
P
V
M
G
F
K
A
I
V
Y
N
G
S
Y
H
E
V
D
S
S
D
L
A
F
Q
I
A
A
S
L
A
F
K
K
V
M
A
E
A
H
P
V
L
L
E
P
I
Y
R
L
K
V
L
A
P
Q
E
R
V
G
D
V
L
S
D
L
Q
A
R
R
G
R
I
L
G
M
E
Q
E
G
A
L
S
V
V
H
A
E
V
P
L
A
E
V
-
L
E
Y
Y
K
A
L
P
G
L
T
G
G
A
G
A
Y
T
L
E
F
S
H
Y
A
E
V
P
P
H
L
A
Q
R
I
V
Q
E
R
A
Q
E
107
HHSearch
72.96
35%
-66
* C2 *
2DY1
2
?
A:
[6-664]
------
G
A
M
I
R
T
V
A
L
V
G
H
A
G
S
G
K
T
T
L
T
E
A
L
L
Y
K
T
G
A
K
E
R
R
G
R
V
E
E
G
T
T
T
T
D
Y
T
P
E
A
K
L
H
R
T
T
V
R
T
G
V
A
P
L
L
F
R
-----
G
-------
H
R
V
F
L
L
D
A
P
G
Y
G
D
F
V
G
E
I
R
G
A
L
E
A
A
D
A
A
L
V
A
V
S
A
E
A
G
V
Q
V
G
T
E
R
A
W
T
V
A
E
R
L
G
L
P
R
M
V
V
V
T
K
L
D
K
G
G
-
D
Y
Y
A
L
L
E
D
L
R
S
T
L
G
P
-
I
L
P
I
D
L
P
L
Y
E
G
G
K
W
V
G
L
I
D
V
F
H
G
K
A
Y
R
Y
E
N
-
G
E
E
R
E
---
A
E
V
P
P
E
E
R
E
R
V
Q
R
F
R
Q
E
V
L
E
A
I
V
E
T
D
E
G
L
L
E
K
Y
L
E
G
E
E
V
T
G
E
A
L
E
K
A
F
H
E
A
V
R
R
G
L
L
Y
P
V
A
L
A
S
G
E
R
E
I
G
V
L
P
L
L
E
L
I
L
E
A
L
P
S
P
T
E
R
F
--------------------
G
D
G
P
P
L
A
K
V
F
K
V
Q
V
D
P
F
M
G
Q
V
A
Y
L
R
L
Y
R
G
R
L
K
P
G
D
S
L
Q
S
E
A
G
--
Q
V
R
L
P
H
L
Y
V
P
M
G
K
D
L
L
E
V
E
E
A
E
A
G
F
V
L
G
V
----
P
K
A
E
G
L
H
R
G
M
V
L
W
Q
G
E
K
-
P
ES
E
E
V
P
F
A
R
L
P
-----
D
P
N
V
P
V
A
L
H
P
K
G
R
T
D
E
A
R
L
G
E
A
L
R
K
L
L
E
E
D
P
S
L
K
L
E
R
Q
E
E
T
---
G
E
L
L
L
W
G
H
G
E
L
H
L
A
T
A
K
E
R
L
Q
-
D
Y
G
V
E
V
E
F
S
V
P
K
V
P
Y
R
E
T
I
K
K
V
-
A
E
G
Q
G
K
Y
K
K
Q
T
G
G
H
G
Q
Y
G
D
V
W
L
R
L
E
P
A
S
E
------
Y
G
F
E
W
R
I
T
G
G
V
I
P
S
K
Y
Q
E
A
I
E
E
G
I
K
E
A
A
K
K
G
V
L
A
G
F
P
V
M
G
F
K
A
I
V
Y
N
G
S
Y
H
E
V
D
S
S
D
L
A
F
Q
I
A
A
S
L
A
F
K
K
V
M
A
E
A
H
P
V
L
L
E
P
I
Y
R
L
K
V
L
A
P
Q
E
R
V
G
D
V
L
S
D
L
Q
A
R
R
G
R
I
L
G
M
E
Q
E
G
A
L
S
V
V
H
A
E
V
P
L
A
E
V
-
L
E
Y
Y
K
A
L
P
G
L
T
G
G
A
G
A
Y
T
L
E
F
S
H
Y
A
E
V
P
P
H
L
A
Q
R
I
V
Q
E
R
A
Q
E
111
HHSearch
58.15
27%
-68
- C2 -
3CB4
-
LEPA_ECOLI
D:
[2-481]
-------
K
N
I
R
N
F
S
I
I
A
H
I
----
S
T
L
S
D
R
I
I
Q
I
C
G
G
-----------------------------
Q
S
V
T
L
D
Y
K
ASDGE
T
-------
Y
Q
L
N
F
I
D
T
P
G
H
V
D
F
S
Y
E
V
S
R
S
L
A
A
C
E
G
A
L
L
V
V
D
A
G
Q
G
V
E
A
Q
T
L
A
N
C
Y
T
A
M
E
M
D
L
E
V
V
P
V
L
N
K
I
D
L
P
A
A
D
P
E
R
V
A
E
E
I
E
D
I
V
G
-----------------------------------------------------------------------------------------------
I
D
A
T
D
A
V
R
C
S
A
K
T
G
V
G
V
Q
D
V
L
E
R
L
V
R
D
I
P
P
P
E
G
D
---------------------
P
E
G
P
L
Q
A
L
I
I
D
S
W
F
D
N
Y
L
G
V
V
S
L
I
R
I
K
N
G
T
L
R
K
G
D
K
V
K
V
M
S
T
G
Q
T
Y
N
A
D
R
L
G
I
F
T
P
-
K
Q
V
D
R
T
E
L
K
C
G
E
V
G
W
L
VCAI
K
D
I
H
G
A
P
V
G
D
T
L
T
L
A
R
N
-
P
AE
K
A
L
P
G
F
K
K
V
-----
K
P
Q
V
Y
A
G
L
F
P
V
S
S
D
D
Y
E
A
F
R
D
A
L
G
K
L
S
L
N
D
A
S
L
F
Y
E
P
E
S
S
S
ALG
F
G
F
R
C
G
F
L
G
L
L
H
M
E
I
I
Q
E
R
L
E
R
E
Y
D
L
D
L
I
T
T
A
P
T
V
V
Y
E
V
E
T
T
S
R
-
E
V
---
I
---------------
Y
V
D
S
P
S
----------------------
K
--------------------
L
P
A
V
----------------------------------
N
N
I
Y
E
L
R
E
P
I
A
E
C
H
M
L
L
P
Q
A
Y
L
G
N
V
I
T
L
C
V
E
K
R
G
V
Q
T
N
M
V
Y
H
G
N
Q
V
A
L
T
Y
E
I
P
M
A
E
V
V
L
D
F
F
D
R
L
K
S
T
S
R
G
Y
A
S
L
D
Y
N
F
K
R
F
Q
A
S
D
M
V
R
V
D
V
L
I
N
G
E
R
V
D