@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1839: (2015-12-11 )
MTNILEVKNLTKIFGKKQKAALEMVKQGKSKTEILEKTGATVGVYDASFEIKEGEIFVIMGLSGSGKSTLVRMLNRLIDPSSGNIYLDGKDIAKMNVEDLRNIRRHDINMVFQNFGLFPHRTILENTEFGLEMRGVSKEERTMLAEKALDNAGLLPFKDQYPSQLSGGMQQRVGLARALANSPKILLMDEAFSALDPLIRREMQDELLDLQDTNKQTIIFISHDLNEALRIGDRIALMKDGEIMQIGTGEEILTNPANDFVREFVEDVDRSKVLTAQNIMIKPLTTVLEIDGPQVALTRMHREEVSMLMATNRRRQLLGSLTADAAIEARKKGLPLSEVIDKDVVTVSKDTVITDIMPLIYDSSAPIAVTDDNDRLLGVIIRGRVIEALANVQDETVVESPKETVEA
Atome Classification :
(34 SA)
.........10........20........30........40........50........60........70........80........90.-------.......---100..--.....110.......120.....-..130--....-....140.......150..-..-...160------........170.......180.......190.......200.......210.....-.---...220.......230.......240.......250.......260.......270...-....280.......290......-.300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
N
I
L
E
V
K
N
L
T
K
I
FG
K
K
Q
K
A
A
L
E
M
V
K
QGK
S
K
T
E
I
L
E
KTG
A
T
V
G
V
YDA
S
F
E
IKEG
E
I
F
V
I
MGLSGS
G
K
S
T
L
V
R
M
L
N
R
LIDPSSG
N
I
Y
LDG
K
D
I
-------
A
KM
N
V
E
D
---
L
R
N
I
R
--
R
H
D
I
N
M
V
F
Q
NFGLFP
H
R
T
I
LENT-EF
G
-
L
--
E
MRG-V
S
K
E
E
R
T
M
L
A
E
K
ALDNAGL-LP-FKDQ
Y
-------
P
S
Q
L
S
G
G
M
Q
Q
R
V
G
L
A
R
A
LANS
P
K
I
L
L
M
D
E
A
F
S
A
L
D
P
L
I
R
R
E
M
Q
D
E
L
L
DL--QDTNK-
Q
---
T
I
I
F
I
SHD
L
N
E
A
L
RIG
D
R
I
A
L
MKDG
E
I
M
Q
IGTG
E
E
ILTN
P
A
N
D
F
V
R
E
F
V
E
DVDRS
K
V
L
T-AQ
N
I
M
I
KPL
T
T
V
L
EIDG
P
Q
V
A
L
T
-
R
M
H
R
E
E
V
S
M
L
M
A
T
N
R
R
R
Q
L
L
G
S
L
T
A
D
A
A
I
E
A
R
KKGL
P
L
S
E
V
IDKD
V
V
TVSK
D
T
V
I
T
D
I
M
P
L
IYDSSA
P
I
A
V
TDDND
R
L
L
G
V
I
IR
G
R
V
I
E
A
L
ANVQ
D
E
T
VVES
P
K
E
TVEA
110
Fugue
83.36
29%
-75
- C2 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
--------------------
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
-------
T
T
L
S
E
S
E
---
L
T
K
A
R
--
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
-
A
L
P
-
L
--
E
L
D
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
-
K
H
D
S
Y
-------
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
--
N
R
R
L
G
-
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
-------------------------
I
P
-
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
-----
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
---------
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
------
26
PsiBlast_CBE
82.23
39%
-94
- C2 -
4U02
1
?
B:
[1-241]
M
E
P
I
I
R
I
R
N
L
H
K
W
F
G
-----
P
L
H
V
L
K
----------------
G
I
H
---
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
------------
L
S
V
K
D
DRA
L
R
E
I
R
--
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
-
T
L
A
P
M
--
R
V
R
R
-
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
-
L
D
-
Q
A
R
K
Y
-------
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
D
V
--
M
R
D
L
A
-
Q
GGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
-------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
81.87
39%
-95
- C2 -
4U02
1
?
A:
[1-241]
M
E
P
I
I
R
I
R
N
L
H
K
W
F
G
-----
P
L
H
V
L
K
----------------
G
I
H
---
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
------------
L
S
V
K
D
DRA
L
R
E
I
R
--
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
-
T
L
A
P
M
--
R
V
R
R
-
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
-
L
D
-
Q
A
R
K
Y
-------
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
D
V
--
M
R
D
L
A
-
Q
GG
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
-------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
81.84
39%
-94
- C2 -
4U02
1
?
C:
[1-241]
M
E
P
I
I
R
I
R
N
L
H
K
W
F
G
-----
P
L
H
V
L
K
----------------
G
I
H
---
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
------------
L
S
V
K
D
DRA
L
R
E
I
R
--
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
-
T
L
A
P
M
--
R
V
R
R
-
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
-
L
D
-
Q
A
R
K
Y
-------
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
D
V
--
M
R
D
L
A
-
Q
GGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
-------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.39
39%
-96
- C2 -
4U00
3
?
A:
[3-241]
--
P
I
I
R
I
R
N
L
H
K
W
F
G
-----
P
L
H
V
L
K
----------------
G
I
H
---
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
------------
L
S
V
K
D
DRA
L
R
E
I
R
--
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
-
T
L
A
P
M
--
R
V
R
R
-
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
-
L
D
-
Q
A
R
K
Y
-------
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
D
V
--
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
-------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
81.29
39%
-94
- C2 -
4U02
1
?
D:
[2-241]
-
E
P
I
I
R
I
R
N
L
H
K
W
F
G
-----
P
L
H
V
L
K
----------------
G
I
H
---
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
------------
L
S
V
K
D
DRA
L
R
E
I
R
--
R
-
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
-
T
L
A
P
M
--
R
V
R
R
-
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
-
L
D
-
Q
A
R
K
Y
-------
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
D
V
--
M
R
D
L
A
-
Q
GGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
-------------------------------------------------------------------------------------------------------------------------------------------
113
Fugue
80.92
28%
-66
- C2 -
1OXS
23
?
C:
[1-352]
M
V
R
-
I
I
V
K
N
V
S
K
V
F
K
K
----------------------
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
-------
A
S
N
G
K
L
I
---
V
P
P
E
D
--
R
-
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
-
A
F
P
-
L
--
T
N
M
K
-
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
-
H
H
-
V
L
N
H
F
-------
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
--
Q
S
R
L
G
-
V
---
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
---------------------
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
------------
111
Fugue
80.62
27%
-69
- C2 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
A
R
S
-----------------------
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
-------
T
D
L
P
P
Q
K
-----------
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
-
S
F
G
-
L
--
R
E
K
R
-
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
-
E
S
-
Y
A
N
R
F
-------
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
--
H
D
E
M
G
-
V
---
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
-
Q
N
G
--------
R
I
E
V
A
G
A
A
L
P
V
D
-
P
A
V
S
E
G
S
E
V
A
V
V
V
------------------
R
P
K
D
V
E
L
Q
P
A
S
E
R
E
A
-----
H
A
Q
V
V
R
S
A
F
K
--
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
V
W
E
V
H
V
P
S
A
D
R
H
R
W
S
P
G
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
11
PsiBlast_PDB
79.18
40%
-94
- C2 -
4YMV
1
?
J:
[20-239]
----------------------------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
NN-----
G
K
V
N
I
-------
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
--
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
-
K
K
D
Q
Y
-------
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
N
E
G
--
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
--------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
79.04
40%
-93
- C2 -
4YMV
1
?
A:
[20-239]
----------------------------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
NN-----
G
K
V
N
I
-------
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
--
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
-
K
K
D
Q
Y
-------
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
N
E
G
--
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
--------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
78.86
40%
-95
- C2 -
4YMS
-
?
J:
[20-239]
----------------------------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
NN-----
G
K
V
N
I
-------
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
--
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
-
K
K
D
Q
Y
-------
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
N
E
G
--
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
--------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
78.78
40%
-95
- C2 -
4YMU
2
?
A:
[20-239]
----------------------------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
NN-----
G
K
V
N
I
-------
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
--
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
-
K
K
D
Q
Y
-------
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
N
E
G
--
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
--------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
78.72
40%
-98
- C2 -
4YMT
-
?
J:
[20-239]
----------------------------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
NN-----
G
K
V
N
I
-------
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
--
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
-
K
K
D
Q
Y
-------
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
N
E
G
--
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
--------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.60
40%
-94
- C2 -
4YMU
2
?
J:
[20-239]
----------------------------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
NN-----
G
K
V
N
I
-------
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
--
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
-
K
K
D
Q
Y
-------
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
N
E
G
--
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
--------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
77.90
40%
-93
- C2 -
4YMW
-
?
J:
[20-239]
----------------------------------------------
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
NN-----
G
K
V
N
I
-------
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
--
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
-
K
K
D
Q
Y
-------
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
N
E
G
--
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
--------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
76.69
35%
-90
- C2 -
1B0U
4
HISP_SALTY
A:
[26-254]
-----------------------------------------------
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KD
G
Q
L
K
V
A
D
---
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
-
I
--
Q
V
L
G
-
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
-
A
Q
G
K
Y
-------
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
--
A
E
E
G
K
-----
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
K
L
E
H
---------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
75.83
36%
-63
- C2 -
4M1M
2
MDR1A_MOUSE
B:
[1053-1264]
-----------------------------------------------
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
A
G
S
V
F
L
D
G
K
E
I
-------
K
Q
L
N
V
Q
W
---
L
R
A
------
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
I
-
A
Y
G
-
D
--
N
S
R
V
-
V
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
-
D
S
-
L
P
D
K
Y
NTRVGDK
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
-
E
A
L
D
---
K
A
R
E
G
-
R
---
T
C
I
V
I
A
H
R
L
S
-
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
K
G
I
Y
F
S
M
V
S
V
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
75.67
36%
-70
- C2 -
4M1M
3
MDR1A_MOUSE
A:
[1053-1264]
-----------------------------------------------
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
A
G
S
V
F
L
D
G
K
E
I
-------
K
Q
L
N
V
Q
W
---
L
R
A
------
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
I
-
A
Y
G
-
D
--
N
S
R
V
-
V
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
-
D
S
-
L
P
D
K
Y
NTRVGDK
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
-
E
A
L
D
---
K
A
R
E
G
-
R
---
T
C
I
V
I
A
H
R
L
S
-
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
K
G
I
Y
F
S
M
V
S
V
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
74.68
35%
-77
- C2 -
4LSG
3
MDR1A_MOUSE
B:
[1053-1264]
-----------------------------------------------
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
A
G
S
V
F
L
D
G
K
E
I
-------
K
Q
L
N
V
Q
W
---
L
R
A
------
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
I
-
A
Y
G
-
D
--
N
S
R
V
-
V
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
-
D
S
-
L
P
D
K
Y
NTRVGDK
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
--
R
E
--
G
-
R
---
T
C
I
V
I
A
H
R
L
S
-
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
K
G
I
Y
F
S
M
V
S
V
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
74.64
35%
-76
- C2 -
4LSG
3
MDR1A_MOUSE
A:
[1053-1264]
-----------------------------------------------
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
A
G
S
V
F
L
D
G
K
E
I
-------
K
Q
L
N
V
Q
W
---
L
R
A
------
Q
L
G
I
V
S
Q
E
P
I
L
F
D
C
-
S
I
A
E
N
I
-
A
Y
G
-
D
--
N
S
R
V
-
V
S
Y
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
-
D
S
-
L
P
D
K
Y
NTRVGDK
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
--
R
E
--
G
-
R
---
T
C
I
V
I
A
H
R
L
S
-
T
I
Q
N
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
Q
K
G
I
Y
F
S
M
V
S
V
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
69.17
39%
-78
- C2 -
2OLK
1
?
C:
[46-262]
-------------------------------------------------
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--------
K
A
K
D
T
N
---
L
N
K
V
R
--
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
--
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
H
A
Y
-------
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
MK
Q
L
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
--------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
68.95
39%
-69
- C2 -
3C41
3
?
K:
[25-241]
-------------------------------------------------
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-------
K
A
K
D
T
N
-----
L
N
K
V
--
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
--
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
H
A
Y
-------
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
MK
Q
L
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
--------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
68.46
39%
-75
- C2 -
3C4J
4
?
B:
[46-262]
-------------------------------------------------
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--------
K
A
K
D
T
N
---
L
N
K
V
R
--
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
--
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
H
A
Y
-------
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
MK
Q
L
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
--------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
68.00
39%
-74
- C2 -
2OLK
2
?
B:
[46-262]
-------------------------------------------------
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--------
K
A
K
D
T
N
---
L
N
K
V
R
--
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
--
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
H
A
Y
-------
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
MK
Q
L
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
--------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
67.95
39%
-76
- C2 -
2OLK
1
?
A:
[46-262]
-------------------------------------------------
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--------
K
A
K
D
T
N
---
L
N
K
V
R
--
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
--
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
H
A
Y
-------
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
--------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
67.78
39%
-73
- C2 -
2OLK
1
?
D:
[46-262]
-------------------------------------------------
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--------
K
A
K
D
T
N
---
L
N
K
V
R
--
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
--
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
H
A
Y
-------
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
MK
Q
L
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
--------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
67.48
39%
-68
- C2 -
3C41
3
?
J:
[25-241]
-------------------------------------------------
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-------
K
A
K
D
T
N
-----
L
N
K
V
--
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
--
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
H
A
Y
-------
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
MK
Q
L
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
--------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
67.40
39%
-76
- C2 -
2OLJ
4
?
A:
[46-262]
-------------------------------------------------
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--------
K
A
K
D
T
N
---
L
N
K
V
R
--
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
--
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
H
A
Y
-------
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
--------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
66.88
39%
-71
- C2 -
2Q0H
4
?
B:
[46-262]
-------------------------------------------------
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--------
K
A
K
D
T
N
---
L
N
K
V
R
--
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
--
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
H
A
Y
-------
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
--------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
65.74
39%
-73
- C2 -
3C4J
3
?
A:
[46-262]
-------------------------------------------------
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--------
K
A
K
D
T
N
---
L
N
K
V
R
--
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
--
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
H
A
Y
-------
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
--------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
65.50
39%
-71
- C2 -
2Q0H
4
?
A:
[46-262]
-------------------------------------------------
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--------
K
A
K
D
T
N
---
L
N
K
V
R
--
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
--
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
H
A
Y
-------
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
--------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
65.49
42%
-78
- C2 -
3TIF
7
Y796_METJA
A:
[23-223]
---------------------------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
-------
N
D
L
D
D
D
E
---
L
T
K
I
R
--
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
-
L
IF
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
-
E
E
R
F
A
N
H
K
-------
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
--
N
E
E
D
G
-
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
65.16
42%
-79
- C2 -
1L2T
4
Y796_METJA
A:
[23-223]
---------------------------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
-------
N
D
L
D
D
D
E
---
L
T
K
I
R
--
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
-
E
L
P
-
L
IF
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
-
E
E
R
F
A
N
H
K
-------
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
--
N
E
E
D
G
-
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
65.06
39%
-68
- C2 -
2OLJ
3
?
B:
[46-262]
-------------------------------------------------
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--------
K
A
K
D
T
N
---
L
N
K
V
R
--
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
--
K
V
R
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
-
K
A
H
A
Y
-------
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
MK
Q
L
A
N
E
G
M
---
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
--------------------------------------------------------------------------------------------------------------------------------------------