@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1852: (2015-12-11 )
MTRPIGIYEKATPKHFNWLERLQFAKELGFDFVELSIDESDERLARLEWSKEERLELVKAIFETGVRVPTITFSGHRRFPMGSNNPEKEARAMDMMKKCIVFAQDIGIRNIQLAGYDVYYEEKSPETRARFIKNLRQACTWAEEAQVILSIEIMDDPFMNSIEKYLAVEKEIDSPYLFVYPDTGNVSAWHNDLWSEFYNGHRSIAALHIKDTYAVTETSKGQFRDVPFGQGCVDWEEMFAVIKKTNYNGPFLIEMWSENCETVEETRAAIKEAQDFLYPLMEKTGVK
Atome Classification :
(20 SA)
.........10...---.--....20........30........40........50........60........-70.....---.----.-.-----80-.....----....90.....-...100.......110.--.....-.120---.-........130.......140.......150...-----.--------.---..160.......170.......180...-....190........200--.......210......-----------.220-...--......230.-......240.......250........260---------------.-------------.----------------......270.......280.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTRPIGIYEKATP
K
---
H
--
F
N
W
L
E
R
L
Q
F
A
K
E
LGF
D
F
V
E
L
SIDE
S
D
E
R
L
A
R
LEW
S
K
E
E
R
L
E
L
V
K
A
I
F
ETGVR
V
P
-
T
I
T
FSGH---R----R-F-----P--MGSNN----
P
E
K
E
A
R
A
M
D
M
M
-
K
K
C
I
V
F
A
Q
DIGI
R
N
I
Q
L--AG
Y
D
V
-
Y
Y
-----E-EKS
P
E
T
R
A
R
F
I
K
N
L
R
Q
AC
T
W
A
E
E
A
Q
V
I
L
S
I
E
IMD-----
D
--------
P
---
F
M
N
S
I
E
K
Y
L
A
V
E
KEIDS
P
Y
L
F
V
YPDTGN-
V
S
A
W
H
-
N
D
L
W
S
E
F
YNGH
R
--
S
I
A
A
L
H
I
K
D
T
Y
A
VTET-----------SK---GQF--RDVPFGQGCV-
D
W
E
E
M
F
A
V
I
K
KTNYNG
P
-
F
L
I
E
M
W
SEN
C
E
----------------
T
-------------
V
----------------
E
E
T
R
A
A
I
K
E
A
Q
D
F
L
Y
P
L
M
E
KTGVK
23
PsiBlast_CBE
98.16
52%
-103
- C1 -
3CQI
1
ULAE_ECO57
B:
[18-291]
---
P
L
G
I
Y
E
K
A
L
P
A
-------
C
W
L
E
R
L
Q
L
A
K
T
L
G
F
D
F
V
E
M
S
V
D
E
T
D
E
R
L
S
R
L
D
W
S
R
E
Q
R
L
A
L
V
N
A
I
V
E
T
G
V
R
V
P
-
S
M
C
L
S
A
H
---
R
----
R
-
F
-----
P
--
L
G
S
E
D
----
D
A
V
R
A
Q
G
L
E
I
M
-
R
K
A
I
Q
F
A
Q
D
V
G
I
R
V
I
Q
L
--
A
G
Y
D
V
-
Y
Y
-----
Q
-
E
A
N
N
E
T
R
R
R
F
R
D
G
L
K
E
S
V
E
M
A
S
R
A
Q
V
T
L
A
M
E
I
M
D
-----
Y
--------
P
---
L
M
N
S
I
S
K
A
L
G
Y
A
H
Y
L
N
N
P
W
F
Q
L
Y
P
D
I
G
N
-
L
S
A
W
D
-
N
D
V
Q
M
E
L
Q
A
G
I
G
--
H
I
V
A
V
H
V
K
D
------
T
-----------
K
P
-----
F
--
K
N
V
P
F
G
E
G
V
V
-
D
F
E
R
C
F
E
T
L
K
Q
S
G
Y
C
G
P
-
Y
L
I
E
M
W
S
---
E
----------------
T
-------------
A
----------------
E
D
P
A
A
E
V
A
K
A
R
D
W
V
K
A
R
M
A
K
A
G
M
V
24
HHSearch
97.98
53%
-101
- C1 -
3CQJ
2
ULAE_ECO57
A:
[16-291]
-
Q
I
P
L
G
I
Y
E
K
A
L
P
A
---
G
--
E
C
W
L
E
R
L
Q
L
A
K
T
L
G
F
D
F
V
E
M
S
V
D
E
T
D
E
R
L
S
R
L
D
W
S
R
E
Q
R
L
A
L
V
N
A
I
V
E
T
G
V
R
V
P
-
S
M
C
L
S
A
H
---
R
----
R
-
F
-----
P
--
L
G
S
E
D
----
D
A
V
R
A
Q
G
L
E
I
M
-
R
K
A
I
Q
F
A
Q
D
V
G
I
R
V
I
Q
L
--
A
G
Y
D
V
-
Y
Y
-----
Q
-
E
A
N
N
E
T
R
R
R
F
R
D
G
L
K
E
S
V
E
M
A
S
R
A
Q
V
T
L
A
M
E
I
M
D
-----
Y
--------
P
---
L
M
N
S
I
S
K
A
L
G
Y
A
H
Y
L
N
N
P
W
F
Q
L
Y
P
D
I
G
N
-
L
S
A
W
D
-
N
D
V
Q
M
E
L
Q
A
G
I
G
--
H
I
V
A
V
H
V
K
D
T
K
P
--------------------
G
V
F
--
K
N
V
P
F
G
E
G
V
V
-
D
F
E
R
C
F
E
T
L
K
Q
S
G
Y
C
G
P
-
Y
L
I
E
M
W
S
E
T
A
------------------------------------------------
E
D
P
A
A
E
V
A
K
A
R
D
W
V
K
A
R
M
A
K
A
G
M
-
22
PsiBlast_CBE
97.79
52%
-102
- C1 -
3CQJ
2
ULAE_ECO57
B:
[18-291]
---
P
L
G
I
Y
E
K
A
L
P
A
---
G
---
C
W
L
E
R
L
Q
L
A
K
T
L
G
F
D
F
V
E
M
S
V
D
E
T
D
E
R
L
S
R
L
D
W
S
R
E
Q
R
L
A
L
V
N
A
I
V
E
T
G
V
R
V
P
-
S
M
C
L
S
A
H
---
R
----
R
-
F
-----
P
--
L
G
S
E
D
----
D
A
V
R
A
Q
G
L
E
I
M
-
R
K
A
I
Q
F
A
Q
D
V
G
I
R
V
I
Q
L
--
A
G
Y
D
V
-
Y
Y
-----
Q
-
E
A
N
N
E
T
R
R
R
F
R
D
G
L
K
E
S
V
E
M
A
S
R
A
Q
V
T
L
A
M
E
I
M
D
-----
Y
--------
P
---
L
M
N
S
I
S
K
A
L
G
Y
A
H
Y
L
N
N
P
W
F
Q
L
Y
P
D
I
G
N
-
L
S
A
W
D
-
N
D
V
Q
M
E
L
Q
A
G
I
G
--
H
I
V
A
V
H
V
K
D
------
T
-----------
K
P
---
G
V
F
--
K
N
V
P
F
G
E
G
V
V
-
D
F
E
R
C
F
E
T
L
K
Q
S
G
Y
C
G
P
-
Y
L
I
E
M
W
S
---
E
----------------
T
-------------
A
----------------
E
D
P
A
A
E
V
A
K
A
R
D
W
V
K
A
R
M
A
K
A
G
M
-
44
Fugue
97.73
53%
-100
- C1 -
3CQJ
2
ULAE_ECO57
A:
[16-291]
-
Q
I
P
L
G
I
Y
E
K
A
L
P
A
---
G
--
E
C
W
L
E
R
L
Q
L
A
K
T
L
G
F
D
F
V
E
M
S
V
D
E
T
D
E
R
L
S
R
L
D
W
S
R
E
Q
R
L
A
L
V
N
A
I
V
E
T
G
V
R
V
P
-
S
M
C
L
S
A
H
---
R
----
R
-
F
-----
P
--
L
G
S
E
D
----
D
A
V
R
A
Q
G
L
E
I
M
-
R
K
A
I
Q
F
A
Q
D
V
G
I
R
V
I
Q
L
--
A
G
Y
D
V
-
Y
Y
-----
Q
-
E
A
N
N
E
T
R
R
R
F
R
D
G
L
K
E
S
V
E
M
A
S
R
A
Q
V
T
L
A
M
E
I
M
D
-----
Y
--------
P
---
L
M
N
S
I
S
K
A
L
G
Y
A
H
Y
L
N
N
P
W
F
Q
L
Y
P
D
I
G
N
-
L
S
A
W
D
-
N
D
V
Q
M
E
L
Q
A
G
I
G
--
H
I
V
A
V
H
V
K
D
T
K
-----------------
P
---
G
V
F
--
K
N
V
P
F
G
E
G
V
V
-
D
F
E
R
C
F
E
T
L
K
Q
S
G
Y
C
G
P
-
Y
L
I
E
M
W
S
E
T
--------------------------------
A
----------------
E
D
P
A
A
E
V
A
K
A
R
D
W
V
K
A
R
M
A
K
A
G
M
-
21
PsiBlast_CBE
97.44
52%
-100
- C1 -
3CQK
3
ULAE_ECO57
B:
[18-291]
---
P
L
G
I
Y
E
K
A
L
P
A
---
G
--
E
C
W
L
E
R
L
Q
L
A
K
T
L
G
F
D
F
V
E
M
S
V
D
E
T
D
E
R
L
S
R
L
D
W
S
R
E
Q
R
L
A
L
V
N
A
I
V
E
T
G
V
R
V
P
-
S
M
C
L
S
A
H
---
R
----
R
-
F
-----
P
--
L
G
S
E
D
----
D
A
V
R
A
Q
G
L
E
I
M
-
R
K
A
I
Q
F
A
Q
D
V
G
I
R
V
I
Q
L
--
A
G
Y
D
V
-
Y
Y
-----
Q
-
E
A
N
N
E
T
R
R
R
F
R
D
G
L
K
E
S
V
E
M
A
S
R
A
Q
V
T
L
A
M
E
I
M
D
-----
Y
--------
P
---
L
M
N
S
I
S
K
A
L
G
Y
A
H
Y
L
N
N
P
W
F
Q
L
Y
P
D
I
G
N
-
L
S
A
W
D
-
N
D
V
Q
M
E
L
Q
A
G
I
G
--
H
I
V
A
V
H
V
K
D
------
T
-----------
K
P
---
G
V
F
--
K
N
V
P
F
G
E
G
V
V
-
D
F
E
R
C
F
E
T
L
K
Q
S
G
Y
C
G
P
-
Y
L
I
E
M
W
S
---
E
----------------
T
-------------
A
----------------
E
D
P
A
A
E
V
A
K
A
R
D
W
V
K
A
R
M
A
K
A
G
M
-
2
PsiBlast_PDB
96.75
52%
-99
- C1 -
3CQJ
2
ULAE_ECO57
A:
[18-291]
---
P
L
G
I
Y
E
K
A
L
P
A
---
G
--
E
C
W
L
E
R
L
Q
L
A
K
T
L
G
F
D
F
V
E
M
S
V
D
E
T
D
E
R
L
S
R
L
D
W
S
R
E
Q
R
L
A
L
V
N
A
I
V
E
T
G
V
R
V
P
-
S
M
C
L
S
A
H
---
R
----
R
-
F
-----
P
--
L
G
S
E
D
----
D
A
V
R
A
Q
G
L
E
I
M
-
R
K
A
I
Q
F
A
Q
D
V
G
I
R
V
I
Q
L
--
A
G
Y
D
V
-
Y
Y
-----
Q
-
E
A
N
N
E
T
R
R
R
F
R
D
G
L
K
E
S
V
E
M
A
S
R
A
Q
V
T
L
A
M
E
I
M
D
-----
Y
--------
P
---
L
M
N
S
I
S
K
A
L
G
Y
A
H
Y
L
N
N
P
W
F
Q
L
Y
P
D
I
G
N
-
L
S
A
W
D
-
N
D
V
Q
M
E
L
Q
A
G
I
G
--
H
I
V
A
V
H
V
K
D
------
T
-----------
K
P
---
G
V
F
--
K
N
V
P
F
G
E
G
V
V
-
D
F
E
R
C
F
E
T
L
K
Q
S
G
Y
C
G
P
-
Y
L
I
E
M
W
S
---
E
----------------
T
-------------
A
----------------
E
D
P
A
A
E
V
A
K
A
R
D
W
V
K
A
R
M
A
K
A
G
M
-
3
PsiBlast_PDB
96.29
52%
-97
- C1 -
3CQK
3
ULAE_ECO57
A:
[18-291]
---
P
L
G
I
Y
E
K
A
L
P
A
---
G
--
E
C
W
L
E
R
L
Q
L
A
K
T
L
G
F
D
F
V
E
M
S
V
D
E
T
D
E
R
L
S
R
L
D
W
S
R
E
Q
R
L
A
L
V
N
A
I
V
E
T
G
V
R
V
P
-
S
M
C
L
S
A
H
---
R
----
R
-
F
-----
P
--
L
G
S
E
D
----
D
A
V
R
A
Q
G
L
E
I
M
-
R
K
A
I
Q
F
A
Q
D
V
G
I
R
V
I
Q
L
--
A
G
Y
D
V
-
Y
Y
-----
Q
-
E
A
N
N
E
T
R
R
R
F
R
D
G
L
K
E
S
V
E
M
A
S
R
A
Q
V
T
L
A
M
E
I
M
D
-----
Y
--------
P
---
L
M
N
S
I
S
K
A
L
G
Y
A
H
Y
L
N
N
P
W
F
Q
L
Y
P
D
I
G
N
-
L
S
A
W
D
-
N
D
V
Q
M
E
L
Q
A
G
I
G
--
H
I
V
A
V
H
V
K
D
------
T
-----------
K
P
---
G
V
F
--
K
N
V
P
F
G
E
G
V
V
-
D
F
E
R
C
F
E
T
L
K
Q
S
G
Y
C
G
P
-
Y
L
I
E
M
W
S
---
E
----------------
T
-------------
A
----------------
E
D
P
A
A
E
V
A
K
A
R
D
W
V
K
A
R
M
A
K
A
G
M
-
1
PsiBlast_PDB
94.99
52%
-97
- C1 -
3CQI
3
ULAE_ECO57
A:
[18-291]
---
P
L
G
I
Y
E
K
A
L
P
A
---
G
--
E
C
W
L
E
R
L
Q
L
A
K
T
L
G
F
D
F
V
E
M
S
V
D
E
T
D
E
R
L
S
R
L
D
W
S
R
E
Q
R
L
A
L
V
N
A
I
V
E
T
G
V
R
V
P
-
S
M
C
L
S
A
H
---
R
----
R
-
F
-----
P
--
L
G
S
E
D
----
D
A
V
R
A
Q
G
L
E
I
M
-
R
K
A
I
Q
F
A
Q
D
V
G
I
R
V
I
Q
L
--
A
G
Y
D
V
-
Y
Y
-----
Q
-
E
A
N
N
E
T
R
R
R
F
R
D
G
L
K
E
S
V
E
M
A
S
R
A
Q
V
T
L
A
M
E
I
M
D
-----
Y
--------
P
---
L
M
N
S
I
S
K
A
L
G
Y
A
H
Y
L
N
N
P
W
F
Q
L
Y
P
D
I
G
N
-
L
S
A
W
D
-
N
D
V
Q
M
E
L
Q
A
G
I
G
--
H
I
V
A
V
H
V
K
D
------
T
-----------
K
P
---
G
V
F
--
K
N
V
P
F
G
E
G
V
V
-
D
F
E
R
C
F
E
T
L
K
Q
S
G
Y
C
G
P
-
Y
L
I
E
M
W
S
---
E
----------------
T
-------------
A
----------------
E
D
P
A
A
E
V
A
K
A
R
D
W
V
K
A
R
M
A
K
A
G
M
-
40
HHSearch
76.45
21%
-99
- C1 -
3VYL
2
?
A:
[2-283]
--
A
R
I
G
I
H
S
F
V
W
S
A
SSA
Q
--
S
E
L
E
R
T
L
A
N
T
R
D
A
G
F
D
L
I
E
F
S
Y
L
D
P
---------
A
D
V
D
I
G
R
L
A
K
R
I
A
D
L
G
L
G
V
A
I
S
I
G
L
P
A
---------
D
-
G
-----
D
--
I
S
S
A
D
----
K
A
V
A
A
R
G
V
E
I
L
-
N
Q
T
I
A
L
T
R
D
L
G
G
R
K
V
A
G
IL
S
A
G
H
G
L
Q
V
-----
E
-
A
P
T
R
D
Q
W
N
R
S
A
A
A
L
A
K
V
A
E
T
A
K
A
A
G
V
T
L
N
L
E
I
V
N
-----
R
FES-----
N
---
L
L
N
T
A
A
Q
G
L
A
F
I
E
D
T
G
S
D
N
I
F
L
H
L
D
T
F
H
-
M
N
I
E
E
-
A
D
V
G
L
A
I
R
H
A
A
G
--
K
I
G
Y
V
H
I
G
E
S
H
---------------------------
R
G
F
L
G
T
G
N
I
-
D
F
A
A
I
F
D
A
L
T
A
I
G
Y
A
D
D
-
L
S
F
E
S
F
S
S
E
I
V
----------------
D
E
N
L
S
K
K
T
AIWRNL
W
----------------
T
D
N
M
A
L
A
K
H
A
R
A
F
I
G
L
G
L
E
T
A
R
R
K
27
HHSearch
72.02
18%
-96
* C1 *
2QUL
1
DT3E_PSECI
A:
[2-289]
--
N
K
V
G
M
F
Y
T
Y
W
S
T
EW-
M
--
V
D
F
P
A
T
A
K
R
I
A
G
L
G
F
D
L
M
E
I
S
L
G
E
F
H
------
N
L
S
D
A
K
K
R
E
L
K
A
V
A
D
D
L
G
L
T
V
M
-
C
C
I
G
-
L
K
---
S
----
E
-
Y
-----
D
--
F
A
S
P
D
----
K
S
V
R
D
A
G
T
E
Y
V
-
K
R
L
L
D
D
C
H
L
L
G
A
P
V
F
A
G
--
L
T
F
C
A
-
W
P
QSPPL
D
M
K
D
K
R
P
Y
V
D
R
A
I
E
S
V
R
R
V
I
K
V
A
E
D
Y
G
I
I
Y
A
L
E
V
V
N
-----
R
FEQ-----
W
---
L
C
N
D
A
K
E
A
I
A
F
A
D
A
V
D
S
P
A
C
K
V
Q
L
D
T
F
H
-
M
N
I
E
E
-
T
S
F
R
D
A
I
L
A
C
K
G
--
K
M
G
H
F
H
L
G
E
A
---------------------------
N
R
L
P
P
G
E
G
R
L
-
P
W
D
E
I
F
G
A
L
K
E
I
G
Y
D
G
T
-
I
V
M
E
P
F
M
R
K
G
G
S
V
S
R
A
V
GVWRDMSNGA
T
-------------
D
----------------
E
E
M
D
E
R
A
R
R
S
L
Q
F
V
R
D
K
L
A
-----
36
HHSearch
68.27
20%
-93
- C1 -
3TVA
4
?
A:
[10-287]
-
Y
W
P
I
G
V
F
T
S
V
D
--------
A
G
L
G
V
H
L
E
V
A
Q
D
L
K
V
P
T
V
Q
V
H
A
P
H
P
H
------
T
R
T
R
E
H
A
Q
A
F
R
A
K
C
D
A
A
G
I
Q
V
T
-
V
I
F
G
G
F
D
---
G
ESYA
D
-
I
P
T
T
A
R
T
--
V
G
L
V
P
----
L
E
T
R
A
S
R
V
A
E
M
-
K
E
I
S
D
F
A
S
W
V
G
C
P
A
I
G
L
--
H
I
G
F
V
-
P
--------
E
S
S
S
P
D
Y
S
E
L
V
R
V
T
Q
D
L
L
T
H
A
A
N
H
G
Q
A
V
H
L
E
T
G
Q
--------------------
E
S
A
D
H
L
L
E
F
I
E
D
V
N
R
P
N
L
G
I
N
F
D
P
A
N
-
M
I
L
Y
G
T
G
N
P
I
E
A
L
R
K
V
A
R
--
Y
V
R
S
I
H
C
K
D
A
L
W
A
P
V
N
ER---------
G
K
---
S
W
G
--
Q
E
V
A
L
G
T
G
D
V
-
G
M
E
A
Y
L
T
T
L
W
E
I
G
Y
R
G
P
-
L
T
I
E
R
E
I
P
H
D
-------------------------------
P
----------------
V
Q
Q
K
K
D
L
A
S
A
L
E
L
L
T
G
L
R
K
K
I
A
N
C
32
HHSearch
68.27
17%
-95
- C1 -
3VNI
1
?
A:
[2-290]
--
M
K
H
G
I
Y
Y
A
Y
W
E
Q
---
E
WE
A
D
Y
K
Y
Y
I
E
K
V
A
K
L
G
F
D
I
L
E
I
A
A
S
P
L
P
------
F
Y
S
D
I
Q
I
N
E
L
K
A
C
A
H
G
N
G
I
T
L
T
-
V
G
H
G
P
S
A
--------
E
-
Q
-----
N
--
L
S
S
P
D
----
P
D
I
R
K
N
A
K
A
F
Y
-
T
D
L
L
K
R
L
Y
K
L
D
V
H
L
I
G
G
--
A
L
Y
S
Y
-
W
P
IDYTK
T
-
I
D
K
K
G
D
W
E
R
S
V
E
S
V
R
E
V
A
K
V
A
E
A
C
G
V
D
F
C
L
E
V
L
N
-----
R
FEN-----
Y
---
L
I
N
T
A
Q
E
G
V
D
F
V
K
Q
V
D
H
N
N
V
K
V
M
L
D
T
F
H
-
M
N
I
E
E
-
D
S
I
G
G
A
I
R
T
A
G
S
--
Y
L
G
H
L
H
T
G
E
C
---------------------------
N
R
K
V
P
G
R
G
R
I
-
P
W
V
E
I
G
E
A
L
A
D
I
G
Y
N
G
S
-
V
V
M
E
P
F
V
R
M
G
G
----------------
T
-------------
V
G
S
N
I
KVWRDISNGAD
E
K
M
L
D
R
E
A
Q
A
A
L
D
F
S
R
Y
V
L
E
C
----
29
HHSearch
64.38
17%
-89
- C1 -
3KWS
4
?
A:
[24-286]
L
E
L
K
L
S
F
Q
E
G
I
A
P
G
------
E
S
L
N
E
K
L
D
F
M
E
K
L
G
V
V
G
F
E
P
G
G
G
G
L
----------
A
G
R
V
N
E
I
K
Q
A
L
N
G
R
N
I
K
V
S
-
A
I
C
A
G
F
K
----------
G
-----
F
--
I
L
S
T
D
----
P
A
I
R
K
E
C
M
D
T
M
-
K
E
I
I
A
A
A
G
E
L
G
S
T
G
V
I
I
--
V
P
A
F
N
-
G
Q
VPA--
L
-
P
H
T
M
E
T
R
D
F
L
C
E
Q
F
N
E
M
G
T
F
A
A
Q
H
G
T
S
V
I
F
E
P
L
N
-----
R
--------
K
ECF
Y
L
R
Q
V
A
D
A
A
S
L
C
R
D
I
N
N
P
G
V
R
C
M
G
D
F
W
H
-
M
T
W
E
E
-
T
S
D
M
G
A
F
I
S
G
G
E
--
Y
L
Q
H
V
H
V
A
S
R
K
R
-------------------------
R
S
M
P
G
E
D
G
D
A
D
N
Y
I
N
G
F
K
G
L
K
M
I
G
Y
N
N
Y
-
V
S
F
E
C
G
C
Q
G
--------------------------------------------------
D
R
N
V
V
V
P
A
A
V
K
L
L
R
E
Q
W
E
Q
A
---
30
HHSearch
62.22
16%
-81
- C1 -
3QC0
12
?
A:
[4-274]
-
V
E
G
L
S
I
N
L
A
T
I
R
E
---
Q
--
C
G
F
A
E
A
V
D
I
C
L
K
H
G
I
T
A
I
A
P
W
R
D
Q
---------
V
A
A
I
G
L
G
E
A
G
R
I
V
R
A
N
G
L
K
L
T
-
G
L
C
R
G
G
-----------------
F
--
F
P
A
P
D
----
A
S
G
R
E
K
A
I
D
D
N
-
R
R
A
V
D
E
A
A
E
L
G
A
D
C
L
V
L
--
V
A
G
G
L
-
P
G
G----
S
-
K
N
I
D
A
A
R
R
M
V
V
E
G
I
A
A
V
L
P
H
A
R
A
A
G
V
P
L
A
I
E
P
L
H
-----
P
MYAADR--
A
---
C
V
N
T
L
G
Q
A
L
D
I
C
E
T
L
G
-
P
G
V
G
V
A
I
D
V
Y
H
-
V
W
W
D
P
--
D
L
A
N
Q
I
A
R
A
G
K
M
K
A
I
L
A
H
H
I
C
D
W
L
V
P
T
K
-------------
D
---
M
L
T
--
D
R
G
M
M
G
D
G
V
I
-
D
L
K
G
I
R
R
R
I
E
A
A
G
F
H
G
A
-
Q
E
V
E
I
F
S
A
D
N
W
----------------
W
-------------
K
----------------
R
P
A
D
E
V
I
A
T
C
V
E
R
Y
R
N
C
C
------
39
HHSearch
62.01
18%
-83
- C1 -
2ZVR
-
Y416_THEMA
A:
[1-266]
--
M
K
L
S
L
V
I
S
T
S
D
F
---
K
--
G
D
L
R
K
G
M
E
L
A
K
R
V
G
Y
Q
A
V
E
I
A
V
R
D
P
---------
S
I
V
D
W
N
E
V
K
I
L
S
E
E
L
N
L
P
I
C
-
A
I
G
T
G
Q
A
Y
L
A
D
----
G
-
L
-----
S
--
L
T
H
P
N
----
D
E
I
R
K
K
A
I
E
R
V
-
V
K
H
T
E
V
A
G
M
F
G
A
L
V
I
I
G
--
L
V
R
G
R
-
R
E
-----
G
-
R
S
Y
E
E
T
E
E
L
F
I
E
S
M
K
R
L
L
E
L
T
E
H
--
A
K
F
V
I
E
P
L
N
-----
R
YET-----
D
---
F
I
N
T
I
D
D
A
L
R
I
L
R
K
I
N
S
N
R
V
G
I
L
A
D
T
F
H
-
M
N
I
E
E
-
V
N
I
P
E
S
L
K
R
A
G
E
--
K
L
Y
H
F
H
V
A
D
S
---------------------------
N
R
W
A
P
G
C
G
H
F
-
D
F
R
S
V
F
N
T
L
K
E
I
G
Y
N
R
Y
-
V
S
V
E
C
L
P
L
P
G
-------------------------------------------------
G
M
E
E
A
A
E
I
A
F
K
T
L
K
E
L
I
------
52
Fugue
61.72
17%
-79
- C1 -
3TVA
4
?
A:
[9-290]
P
Y
W
P
I
G
V
F
---
T
S
V
---
D
--
A
G
L
G
V
H
L
E
V
A
Q
D
L
K
V
P
T
V
Q
V
H
A
--
P
H
P
H
T
R
T
R
E
H
A
Q
A
F
R
A
K
C
D
A
A
G
I
Q
V
T
V
I
F
G
-
G
F
D
G
E
S
Y
---
A
----
D
-
I
-----
P
--
T
T
A
R
T
VGLV
P
L
E
T
R
A
S
R
V
A
E
M
K
E
I
S
D
F
A
S
W
V
G
C
P
--
A
I
--
G
L
H
I
G
-
F
V
-----
P
-
E
S
S
S
P
D
Y
S
E
L
V
R
V
T
Q
D
L
L
T
H
A
A
N
H
G
Q
A
V
H
L
E
T
G
Q
-----
E
--------
S
-------
A
D
H
L
L
E
F
I
E
D
V
N
R
P
N
L
G
I
N
F
D
P
A
N
M
I
L
Y
G
T
-
G
N
P
I
E
A
L
R
K
V
A
R
--
Y
V
R
S
I
H
C
K
D
A
L
W
A
P
V
N
-----------
E
R
---
G
K
S
W
G
Q
E
V
A
L
G
T
G
D
V
-
G
M
E
A
Y
L
T
T
L
W
E
I
G
Y
R
G
P
-
L
T
I
E
--
R
E
I
P
H
----------------
D
-------------
P
----------------
V
Q
Q
K
K
D
L
A
S
A
L
E
L
L
T
G
L
R
K
K
I
A
N
C
42
HHSearch
61.16
16%
-93
- C1 -
1K77
5
YGBM_ECOLI
A:
[2-258]
--
P
R
F
A
A
N
L
S
M
M
F
T
---
E
--
V
P
F
I
E
R
F
A
A
A
R
K
A
G
F
D
A
V
E
F
L
F
P
Y
--------
N
Y
---
S
T
L
Q
I
Q
K
Q
L
E
Q
N
H
L
T
L
A
-
L
F
N
T
A
P
G
---
D
----
I
N
A
-----
G
EW
G
L
S
A
L
----
P
G
R
E
H
E
A
H
A
D
I
-
D
L
A
L
E
Y
A
L
A
L
N
C
E
Q
V
H
V
--
M
A
G
V
V
-
P
A
-----
G
-
E
D
A
E
R
Y
R
A
V
F
I
D
N
I
R
Y
A
A
D
R
F
A
P
H
G
K
R
I
L
V
E
A
L
S
PGVKP
H
--------
Y
---
L
F
S
S
Q
Y
Q
A
L
A
I
V
E
E
V
A
R
D
N
V
F
I
Q
L
D
T
F
H
-
A
Q
K
V
D
-
G
N
L
T
H
L
I
R
D
Y
A
G
--
K
Y
A
H
V
Q
I
A
G
L
P
--------------------------
D
R
H
E
P
D
D
G
E
I
-
N
Y
P
W
L
F
R
L
F
D
E
V
G
Y
Q
G
W
-
I
G
C
E
Y
K
P
R
G
------------------------------------------------------
L
T
E
E
G
L
G
W
F
D
A
W
R
G
S
----
28
HHSearch
58.87
13%
-70
- C1 -
3U0H
5
?
A:
[3-279]
-
A
M
E
P
C
L
H
P
T
L
V
D
E
------
T
S
L
V
L
Y
L
D
L
A
R
E
T
G
Y
R
Y
V
D
V
P
F
H
W
L
E
A
-----
E
A
E
R
H
G
D
A
A
V
E
A
M
F
Q
R
R
G
L
V
L
A
-
N
L
G
L
P
L
-----------------
N
--
L
Y
D
S
E
----
P
-
V
F
L
R
E
L
S
L
L
-
P
D
R
A
R
L
C
A
R
L
G
A
R
S
V
T
A
--
F
L
W
P
S
-
M
D
-------
E
E
P
V
R
Y
I
S
Q
L
A
R
R
I
R
Q
V
A
V
E
L
L
P
L
G
M
R
V
G
L
E
Y
V
G
-----
P
HHLRHRRY
P
---
F
V
Q
S
L
A
D
L
K
T
F
W
E
A
I
G
A
P
N
V
G
A
L
V
D
S
Y
H
-
W
Y
T
A
G
-
E
H
E
D
D
L
A
Q
L
P
P
E
--
K
V
V
Y
V
H
I
N
D
T
R
D
A
P
E
D
------------
A
---
H
D
G
--
K
R
L
L
P
G
D
G
R
I
-
P
L
V
P
F
L
R
G
L
Y
L
A
G
Y
R
G
P
-
V
A
A
E
V
L
H
E
T
P
-----------------
L
-------------
D
----------------
G
T
G
E
S
R
A
R
L
V
R
E
R
L
E
K
L
I
A
L
A
K
G
-
33
HHSearch
56.39
14%
-87
- C1 -
3DX5
5
ASBF_BACAN
A:
[1-274]
--
M
K
Y
S
L
C
T
I
S
F
R
H
---
Q
L
-
I
S
F
T
D
I
V
Q
F
A
Y
E
N
G
F
E
G
I
E
L
W
G
T
H
A
Q
N
L
Y
---
M
Q
E
Y
E
T
T
E
R
E
L
N
C
L
K
D
K
T
L
E
I
T
-
M
I
S
D
Y
L
D
----------
I
-----
S
--
L
--
S
------
A
D
F
E
K
T
I
E
K
C
-
E
Q
L
A
I
L
A
N
W
F
K
T
N
K
I
R
T
--
F
A
G
Q
K
-
G
S
-----
A
-
D
F
S
Q
Q
E
R
Q
E
Y
V
N
R
I
R
M
I
C
E
L
F
A
Q
H
N
M
Y
V
L
L
E
T
H
P
-----
N
--------
T
---
L
T
D
T
L
P
S
T
L
E
L
L
G
E
V
D
H
P
N
L
K
I
N
L
D
F
L
H
-
I
W
E
S
G
-
A
D
P
V
D
S
F
Q
Q
L
R
P
--
W
I
Q
H
Y
H
F
K
N
I
S
S
A
D
Y
L
HVFE
P
N
N
V
Y
AA
A
G
---
N
R
T
--
G
M
V
P
L
F
E
G
I
V
-
N
Y
D
E
I
I
Q
E
V
R
D
T
--
D
H
F
-
A
S
L
E
W
F
G
H
N
---------------------------------------------------
A
K
D
I
L
K
A
E
M
K
V
L
T
N
R
N
------
41
HHSearch
54.39
15%
-63
- C1 -
2G0W
1
?
A:
[22-290]
-
K
C
P
I
T
I
S
S
Y
T
L
G
T
---
E
--
V
S
F
P
K
R
V
K
V
A
A
E
N
G
F
D
G
I
G
L
R
A
E
N
Y
V
D
A
L
----
A
A
G
L
T
D
E
D
M
L
R
I
L
D
E
H
N
M
K
V
T
-
E
V
E
Y
I
T
Q
-------------------
W
G
T
A
-----
E
D
R
T
A
E
Q
Q
K
K
E
-
Q
T
T
F
H
M
A
R
L
F
G
V
K
H
I
N
C
--
G
L
L
E
--------------
K
I
P
E
E
Q
I
I
V
A
L
G
E
L
C
D
R
A
E
E
L
I
--
I
G
L
E
F
M
P
-----
Y
--------
S
---
G
V
A
D
L
Q
A
A
W
R
V
A
E
A
C
G
R
D
N
A
Q
L
I
C
D
T
W
H
-
W
A
R
A
N
-
Q
T
A
E
S
I
K
N
V
P
A
D
--
R
I
V
S
I
Q
L
C
D
V
H
E
T
P
Y
K
-----------
E
L
R
E
E
S
L
H
--
D
R
L
A
P
G
E
G
Y
G
-
D
T
V
G
F
A
K
I
L
K
E
H
G
V
N
P
R
V
M
G
V
E
V
I
S
D
S
M
V
----------------
A
------------------------------
T
G
L
E
Y
A
A
L
K
V
Y
N
A
T
K
K
V
L
D
E
A
W
P
E