@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1869: (2015-12-11 )
MSHYSIKLQEVFRLAQFQAARYESHYLESWHLLLAMVLVHDSVAGLTFAEYESEVAIEEYEAATILALGRAPKEEITNYQFLEQSPALKKILKLAENISIVVGAEDVGTEHVLLAMLVNKDLLATRILELVGFRGQDDGESVRMVDLRKALERHAGFTKDDIKAIYELRNPKKAKSGASFSDMMKPPSTAGDLADFTRDLSQMAVDGEIEPVIGRDKEISRMVQVLSRKTKNNPVLVGDAGVGKTALAYGLAQRIANGNIPYELRDMRVLELDMMSVVAGTRFRGDFEERMNQIIADIEEDGHIILFIDELHTIMGSGSGIDSTLDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVLVEEPNLEDAYEILLGLKPAYEAFHNVTISDEAVMTAVKVAHRYLTSKNLPDSAIDLLDEASATVQMMIKKNAPSLLTEVDQAILDDDMKSASKALKASYKGKKRKPIAVTEDHIMATLSRLSGIPVEKLTQADSKKYLNLEKELHKRVIGQDDAVTAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKTELAKALAEVLFDDESALIRFDMSEYMEKFAASHLNGAPPGYVGYDEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDDGVLTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDISHDYTAMQKRIMEELKKAYRPEFINRIDEKVVFHSLSQDNMREVVKIMVKPLILALKDKGMDLKFQPSALKHLAEDGYDIEMGARPLRRTIQTQVEDHLSELLLANQVKEGQVIKIGVSKGKLKFDIAKS
Atome Classification :
(22 SA)
.........10........20........30........40....--....50.....-...60........70.....--...80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300........310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430...----------------------------------------------------------------------....440..------....----.450.----.-------------..----...460------------..-------...----...470-....-------...480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780...-....790.......800.....--..810...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSH
Y
S
I
K
L
Q
E
V
F
R
L
A
Q
F
Q
A
A
R
Y
E
S
H
Y
L
E
S
W
H
L
L
L
A
M
V
L
V
HDSVAG--
L
T
F
A
E
YES
E
V
A
-
I
E
EYE
A
A
T
I
L
ALGRA
P
K
E
EI--T
N
Y
Q
F
L
EQS
P
A
L
K
K
I
L
K
L
AEN
I
S
I
V
V
GAEDVG
T
E
H
V
L
L
A
M
L
VN
K
D
L
L
A
T
R
I
L
E
L
VGFRGQDDGE
S
V
R
M
V
D
L
R
K
A
L
E
R
HAGF
T
K
D
D
I
K
A
I
Y
E
LRN
P
K
KAKSGA
S
F
S
DMMKPPSTA
G
D
L
A
D
F
T
R
D
L
S
Q
MAVDGEIEPVIGR
D
K
E
I
S
R
M
V
Q
V
L
S
R
KTKNN
P
V
L
V
GDAGV
G
K
T
A
L
A
Y
G
L
A
Q
R
IANGNI
P
Y
E
LR
D
M
R
V
L
E
L
D
M
M
S
V
V
AGTRFRG
D
F
E
E
R
M
N
Q
I
I
A
D
IEE-DG
H
I
I
L
F
I
D
E
L
H
T
I
MGSGSGID
S
T
L
D
A
A
N
I
L
K
P
A
L
ARG
T
L
RTVGAT
T
Q
E
E
Y
Q
K
H
I
E
K
D
A
A
L
S
R
R
F
A
K
V
L
VEEP
N
L
E
D
A
Y
E
I
L
LGL
K
P
A
Y
E
A
FHNVTI
S
D
E
A
V
M
T
A
V
K
V
A
H
R
Y
L
TSKNL
P
D
S
A
I
D
L
L
D
E
A
S
A
T
V
Q
M
----------------------------------------------------------------------
M
IKKN
A
P
S
L
------
L
T
E
V
----
D
Q
A
I
L
----
D
-------------
D
D
----
M
K
S
A
S
-------------
K
A
-------
L
K
A
----SYKGKK-RK
P
I
-------
A
V
T
E
D
H
I
M
A
T
L
S
R
LSGI
P
V
E
K
L
T
Q
AD
S
K
K
Y
L
N
L
E
K
E
L
H
K
R
VIGQ
D
D
A
V
T
A
I
S
R
A
I
R
RNQSGIRTGKRPIG
S
F
M
F
LGPTGV
G
K
T
E
L
A
K
A
L
A
E
V
LFDDES
A
L
I
R
F
D
M
S
E
Y
M
E
K
F
A
A
S
HLNGAPPGYVGYDEG
G
E
L
T
E
K
VRNKP
Y
S
V
L
L
F
D
E
V
E
K
AH
P
D
I
F
N
V
L
L
Q
VLDDGVLTDSRG
R
K
V
DFS
N
T
I
I
I
M
TSNLGATALRDDKTVGFGAKDIS
H
D
Y
T
A
M
Q
K
R
I
M
E
E
L
K
K
AY
R
P
E
F
I
N
R
I
D
E
K
V
V
F
H
SL
S
Q
D
N
M
R
E
V
V
K
I
M
V
K
P
L
I
L
A
LKDKGM
D
L
K
F
Q
P
S
A
L
K
H
L
A
EDGYDIEMG
A
R
P
L
R
R
T
I
Q
T
Q
V
E
D
H
L
S
-
E
L
L
L
A
N
QVKEG
Q
V
I
K
I
GVSK
G
K
--
L
K
F
D
IAKS
69
Fugue
91.87
43%
-87
* C3 *
1QVR
7
CLPB_THET8
A:
[4-850]
-
E
R
W
T
Q
A
A
R
E
A
L
A
Q
A
Q
V
L
A
Q
R
M
K
H
Q
A
I
D
L
P
H
L
W
A
V
L
L
K
D
E
R
S
L
A
W
--
R
L
L
E
K
A
G
A
D
P
K
-
A
L
K
E
L
Q
E
R
E
L
A
R
L
P
K
V
E
G
A
E
--
V
G
---
Q
Y
L
T
S
R
L
S
G
A
L
N
R
A
E
G
L
M
E
E
L
K
D
R
Y
V
A
V
D
T
L
V
L
A
L
A
E
A
T
P
---------------------------------------
G
L
P
G
L
E
A
L
K
G
A
L
K
E
L
R
G
G
R
T
V
Q
T
E
H
A
E
S
T
Y
N
A
L
E
Q
Y
G
I
D
L
T
R
L
A
A
E
G
K
L
D
P
V
I
G
R
D
E
E
I
R
R
V
I
Q
I
L
L
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
V
E
G
L
A
Q
R
I
V
K
G
D
V
P
E
G
L
K
G
K
R
I
V
S
L
Q
M
-----------
E
F
E
E
R
L
K
A
V
I
Q
E
V
V
Q
S
Q
G
E
V
I
L
F
I
D
E
L
--------------------
K
P
A
L
A
R
G
E
L
R
L
I
G
A
T
T
L
D
E
Y
-
R
E
I
E
K
D
P
A
L
E
R
R
F
Q
P
V
Y
V
D
E
P
T
V
E
E
T
I
S
I
L
R
G
L
K
E
K
Y
E
V
H
H
G
V
R
I
S
D
S
A
I
I
A
A
A
T
L
S
H
R
Y
I
T
E
R
R
L
P
D
K
A
I
D
L
I
D
E
A
A
A
R
L
R
M
A
LE
S
A
P
E
E
I
D
A
L
E
R
K
K
L
Q
L
E
I
E
R
E
A
L
K
K
EKD
P
D
S
Q
E
RL
K
A
I
E
A
E
I
A
K
L
T
E
E
I
A
K
L
R
A
E
W
E
R
E
R
E
I
L
R
K
L
R
E
A
Q
H
R
L
D
E
V
------
R
R
E
I
----
E
L
A
E
R
----
Q
-------------
Y
D
----
L
N
R
A
A
-------------
E
L
R
Y
G
E
L
P
K
L
E
A
----
E
V
E
A
L
S
-
E
K
L
R
GARFVRL
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
--------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
-------
W
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
A
-
44
HHSearch
89.25
45%
-98
- C4 -
3PXI
-
CLPC_BACSU
A:
[3-806]
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
G
I
A
A
--
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
---
G
R
G
Q
E
------
M
S
Q
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
L
N
---------
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
E
T
G
S
----------------------
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
I
R
Q
-
A
G
N
I
I
L
F
I
D
A
---------------------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
----------------------------------------------------------------------
R
S
F
T
---
P
N
------
L
K
E
L
----
E
Q
K
L
D
EVRK
E
KDAAVQSQEFEKA
A
S
LRDT
E
Q
R
L
R
-------------
E
Q
-------
V
E
D
TKKS
W
K
E
K
Q
G
-
Q
E
----------
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
--------------
S
---
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
-----
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
K
D
K
---------------------
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
--
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
-
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
--
F
V
V
K
T
T
A
-
5
PsiBlast_PDB
87.90
42%
-105
- C4 -
3PXI
-
CLPC_BACSU
A:
[6-801]
---
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
G
I
A
A
KA
L
Q
A
L
G
L
G
S
E
K
I
-
Q
K
E
V
E
S
L
----
I
G
R
G
--
Q
E
M
--
S
--
Q
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
------------
V
S
L
N
K
A
R
Q
Q
-----------
V
L
Q
L
L
G
S
N
E
T
G
S
-----
N
S
N
A
N
T
P
T
L
D
S
L
A
---
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
I
R
Q
-
A
G
N
I
I
L
F
I
D
-------------
A
--------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
----------------------------------------------------------------------
R
S
F
T
--
P
N
L
KELEQK
L
D
E
V
RKEK
D
A
A
V
Q
----
S
-------------
Q
E
----
F
E
K
A
A
SLRDTEQRLREQV
E
D
-------
T
K
K
----
S
W
K
E
K
Q
G
Q
E
----------
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
-----------------
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
-----
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
---------------------
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
--
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
-
E
E
L
L
R
G
N
I
H
K
G
Q
H
I
V
L
D
V
E
D
G
E
--
F
V
V
K
T
T
A
-
43
HHSearch
84.02
38%
-91
- C4 -
1R6B
5
CLPA_ECOLI
X:
[1-747]
--
M
L
N
Q
E
L
E
L
S
L
N
M
A
F
A
R
A
R
E
H
R
H
E
F
M
T
V
E
H
L
L
L
A
L
L
S
N
P
S
--
A
R
--
E
A
L
E
A
C
S
V
D
L
V
A
L
R
Q
E
L
E
A
F
I
---
E
Q
T
T
P
V
L
P
AS
E
E
E
R
D
T
Q
P
T
L
S
F
Q
R
V
L
Q
R
A
V
F
H
V
Q
S
S
G
R
N
E
V
T
G
A
N
V
L
V
A
I
F
S
E
Q
E
S
Q
A
A
Y
L
L
R
K
H
E
V
S
R
L
---------
D
V
V
N
F
I
S
H
G
--------------------------------------
L
E
N
F
T
T
N
L
N
Q
L
A
R
V
G
G
I
D
P
L
I
G
R
E
K
E
L
E
R
A
I
Q
V
L
C
R
R
R
K
N
N
P
L
L
V
G
E
S
G
V
G
K
T
A
I
A
E
G
L
A
W
R
I
V
Q
G
D
V
P
E
V
M
A
D
C
T
I
Y
S
L
D
I
G
---
A
G
T
K
Y
R
G
D
F
E
K
R
F
K
A
L
L
K
Q
L
E
Q
-
D
T
N
S
I
L
F
I
D
E
I
H
T
I
I
G
A
G
A
A
S
G
G
Q
V
D
A
A
N
L
I
K
P
L
L
S
S
G
K
I
R
V
I
G
S
T
T
Y
Q
E
F
S
N
I
F
E
K
D
R
A
L
A
R
R
F
Q
K
I
D
I
T
E
P
S
I
E
E
T
V
Q
I
I
N
G
L
K
P
K
Y
E
A
H
H
D
V
R
Y
T
A
K
A
V
R
A
A
V
E
L
A
V
K
Y
I
N
D
R
H
L
P
D
K
A
I
D
V
I
D
E
A
G
A
R
A
R
L
----------------------------------------------------------------------
M
P
V
S
K
-----------------------------------------------------------------------------------------
R
K
K
-------
T
V
N
V
A
D
I
E
S
V
V
A
R
I
A
R
I
P
E
K
S
V
S
Q
S
D
R
D
T
L
K
N
L
G
D
R
L
K
M
L
V
F
G
Q
D
K
A
I
E
A
L
T
E
A
I
K
M
A
R
A
G
L
G
H
E
H
K
P
V
G
S
F
L
F
A
G
P
T
G
V
G
K
T
E
V
T
V
Q
L
S
K
A
L
---
G
I
E
L
L
R
F
D
M
S
E
Y
M
E
R
H
T
V
S
R
L
I
G
A
P
P
G
Y
V
G
F
D
Q
G
G
L
L
T
D
A
V
I
K
H
P
H
A
V
L
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
M
D
N
G
T
L
T
D
N
N
G
R
K
A
D
F
R
N
V
V
L
V
M
T
T
N
A
G
V
R
-------------------------
A
M
E
E
I
K
K
I
F
T
P
E
F
R
N
R
L
D
N
I
I
W
F
D
H
L
S
T
D
V
I
H
Q
V
V
D
K
F
I
V
E
L
Q
V
Q
L
D
Q
K
G
V
S
L
E
V
S
Q
E
A
R
N
W
L
A
E
K
G
Y
D
R
A
M
G
A
R
P
M
A
R
V
I
Q
D
N
L
K
K
P
L
A
-
N
E
L
L
F
G
S
L
V
D
G
G
Q
V
T
V
A
L
D
K
E
K
NE
L
T
Y
G
F
Q
S
A
7
PsiBlast_PDB
77.84
43%
-87
- C2 -
1R6B
5
CLPA_ECOLI
X:
[169-731]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
N
F
T
T
N
L
N
Q
L
A
R
V
G
G
I
D
P
L
I
G
R
E
K
E
L
E
R
A
I
Q
V
L
C
R
R
R
K
N
N
P
L
L
V
G
E
S
G
V
G
K
T
A
I
A
E
G
L
A
W
R
I
V
Q
G
D
V
P
E
V
M
A
D
C
T
I
Y
S
L
D
I
G
---
A
G
T
K
Y
R
G
D
F
E
K
R
F
K
A
L
L
K
Q
L
E
Q
-
D
T
N
S
I
L
F
I
D
E
I
H
T
I
I
G
A
G
A
A
S
G
G
Q
V
D
A
A
N
L
I
K
P
L
L
S
S
G
K
I
R
V
I
G
S
T
T
Y
Q
E
F
S
N
I
F
E
K
D
R
A
L
A
R
R
F
Q
K
I
D
I
T
E
P
S
I
E
E
T
V
Q
I
I
N
G
L
K
P
K
Y
E
A
H
H
D
V
R
Y
T
A
K
A
V
R
A
A
V
E
L
A
V
K
Y
I
N
D
R
H
L
P
D
K
A
I
D
V
I
D
E
A
G
A
R
A
R
L
----------------------------------------------------------------------
M
-----
P
V
---------------------------------------------------------------------------------
S
K
R
-
K
K
T
V
-------
N
V
A
D
--
I
E
S
V
V
A
R
I
A
R
I
P
E
K
S
V
S
Q
S
D
R
D
T
L
K
N
L
G
D
R
L
K
M
L
V
F
G
Q
D
K
A
I
E
A
L
T
E
A
I
K
M
A
R
A
G
L
G
H
E
H
K
P
V
G
S
F
L
F
A
G
P
T
G
V
G
K
T
E
V
T
V
Q
L
S
K
A
L
G
I
E
---
L
L
R
F
D
M
S
E
Y
M
E
R
H
T
V
S
R
L
I
G
A
P
P
G
Y
V
G
F
D
Q
G
G
L
L
T
D
A
V
I
K
H
P
H
A
V
L
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
M
D
N
G
T
L
T
D
N
N
G
R
K
A
D
F
R
N
V
V
L
V
M
T
T
N
A
G
V
R
------------------
A
-------
M
E
E
I
K
K
I
F
T
P
E
F
R
N
R
L
D
N
I
I
W
F
D
H
L
S
T
D
V
I
H
Q
V
V
D
K
F
I
V
E
L
Q
V
Q
L
D
Q
K
G
V
S
L
E
V
S
Q
E
A
R
N
W
L
A
E
K
G
Y
D
R
A
M
G
A
R
P
M
A
R
V
I
Q
D
N
L
K
K
P
L
A
N
E
L
L
F
G
S
L
V
D
G
G
Q
V
T
V
A
L
D
K
E
K
N
--
E
L
T
Y
G
F
Q
S
6
PsiBlast_PDB
77.29
43%
-86
- C2 -
1KSF
7
CLPA_ECOLI
X:
[169-731]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
N
F
T
T
N
L
N
Q
L
A
R
V
G
G
I
D
P
L
I
G
R
E
K
E
L
E
R
A
I
Q
V
L
C
R
R
R
K
N
N
P
L
L
V
G
E
S
G
V
G
K
T
A
I
A
E
G
L
A
W
R
I
V
Q
G
D
V
P
E
V
M
A
D
C
T
I
Y
S
L
D
I
G
---
A
G
T
K
Y
R
G
D
F
E
K
R
F
K
A
L
L
K
Q
L
E
Q
-
D
T
N
S
I
L
F
I
D
E
I
H
T
I
I
G
A
G
A
A
S
G
G
Q
V
D
A
A
N
L
I
K
P
L
L
S
S
G
K
I
R
V
I
G
S
T
T
Y
Q
E
F
S
N
I
F
E
K
D
R
A
L
A
R
R
F
Q
K
I
D
I
T
E
P
S
I
E
E
T
V
Q
I
I
N
G
L
K
P
K
Y
E
A
H
H
D
V
R
Y
T
A
K
A
V
R
A
A
V
E
L
A
V
K
Y
I
N
D
R
H
L
P
D
K
A
I
D
V
I
D
E
A
G
A
R
A
R
L
----------------------------------------------------------------------
M
-----
P
V
---------------------------------------------------------------------------------
S
K
R
-
K
K
T
V
-------
N
V
A
D
--
I
E
S
V
V
A
R
I
A
R
I
P
E
K
S
V
S
Q
S
D
R
D
T
L
K
N
L
G
D
R
L
K
M
L
V
F
G
Q
D
K
A
I
E
A
L
T
E
A
I
K
M
A
R
A
G
L
G
H
E
H
K
P
V
G
S
F
L
F
A
G
P
T
G
V
G
K
T
E
V
T
V
Q
L
S
K
A
L
G
I
E
---
L
L
R
F
D
M
S
E
Y
M
E
R
H
T
V
S
R
L
I
G
A
P
P
G
Y
V
G
F
D
Q
G
G
L
L
T
D
A
V
I
K
H
P
H
A
V
L
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
M
D
N
G
T
L
T
D
N
N
G
R
K
A
D
F
R
N
V
V
L
V
M
T
T
N
A
G
V
R
--------------
N
S
T
D
A
-------
M
E
E
I
K
K
I
F
T
P
E
F
R
N
R
L
D
N
I
I
W
F
D
H
L
S
T
D
V
I
H
Q
V
V
D
K
F
I
V
E
L
Q
V
Q
L
D
Q
K
G
V
S
L
E
V
S
Q
E
A
R
N
W
L
A
E
K
G
Y
D
R
A
M
G
A
R
P
M
A
R
V
I
Q
D
N
L
K
K
P
L
A
N
E
L
L
F
G
S
L
V
D
G
G
Q
V
T
V
A
L
D
K
E
K
N
--
E
L
T
Y
G
F
Q
S
17
PsiBlast_PDB
69.79
50%
-97
- C2 -
4CIU
1
CLPB_ECOLI
A:
[389-711]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
D
A
E
I
A
E
V
L
A
R
W
T
G
I
P
V
S
R
M
M
E
S
E
R
E
K
L
L
R
M
E
Q
E
L
H
H
R
V
I
G
Q
N
E
A
V
D
A
V
S
N
A
I
R
R
S
R
A
G
L
A
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
C
K
A
L
A
N
F
M
F
D
S
D
E
A
M
V
R
I
D
M
S
E
F
M
E
K
H
S
V
S
R
L
V
G
A
---------
G
G
Y
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
L
D
A
V
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
D
D
G
R
L
T
D
G
Q
G
R
T
V
D
F
R
N
T
V
V
I
M
T
S
N
L
G
S
D
L
I
Q
E
R
----
F
--
L
D
Y
A
H
----
M
K
E
L
V
L
G
V
V
S
H
N
F
R
P
E
F
I
N
R
I
D
E
V
V
V
F
H
P
L
G
E
Q
H
I
A
S
I
A
Q
I
Q
L
K
R
L
Y
K
R
L
E
E
R
G
Y
E
I
H
I
S
D
E
A
L
K
L
L
S
E
N
G
Y
D
P
V
Y
G
A
R
P
L
K
R
A
I
Q
Q
Q
I
E
N
P
L
A
-
Q
Q
I
L
S
G
E
L
V
P
G
K
V
I
R
L
E
V
N
E
D
R
--
I
V
A
V
Q
H
--
21
PsiBlast_CBE
69.08
50%
-98
- C2 -
1QVR
9
CLPB_THET8
C:
[500-848]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
E
V
-------------
E
A
-------
L
S
E
----
K
L
R
G
A
R
-
F
V
R
L
-------
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
--------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
A
-
22
PsiBlast_CBE
68.88
50%
-94
- C2 -
1QVR
3
CLPB_THET8
B:
[500-848]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
E
V
-------------
E
A
-------
L
S
E
----
K
L
R
G
A
R
-
F
V
R
L
-------
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
--------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
A
-
8
PsiBlast_PDB
68.77
50%
-95
- C2 -
1QVR
3
CLPB_THET8
A:
[500-848]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
E
V
-------------
E
A
-------
L
S
E
----
K
L
R
G
A
R
-
F
V
R
L
-------
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
--------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
A
-
24
PsiBlast_CBE
68.36
52%
-101
- C2 -
4LJ7
2
CLPB_THET8
B:
[34-333]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
--
11
PsiBlast_PDB
67.90
52%
-96
- C2 -
4LJ7
2
CLPB_THET8
A:
[30-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
--
23
PsiBlast_CBE
67.36
52%
-102
- C2 -
4LJ7
2
C:
[34-333]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
--
10
PsiBlast_PDB
67.26
53%
-96
- C2 -
4LJ5
1
A:
[6-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
----
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
-------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
--
26
PsiBlast_CBE
66.74
53%
-97
- C2 -
4FD2
1
CLPB_THET8
B:
[13-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
A
R
9
PsiBlast_PDB
66.39
53%
-93
- C2 -
4LJ4
1
A:
[6-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
-
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
--
25
PsiBlast_CBE
66.31
53%
-97
- C2 -
4FD2
1
D:
[13-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
A
R
19
PsiBlast_PDB
66.30
52%
-97
- C2 -
4FCV
1
CLPB_THET8
A:
[16-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
M
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
M
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
M
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
A
R
13
PsiBlast_PDB
65.96
52%
-92
- C2 -
4LJA
3
A:
[6-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
----
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
-------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
--
20
PsiBlast_PDB
65.90
52%
-95
- C2 -
4FCW
1
CLPB_THET8
A:
[16-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
M
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
M
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
M
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
A
R
18
PsiBlast_PDB
65.75
53%
-96
- C2 -
4FD2
1
CLPB_THET8
A:
[13-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
A
R
12
PsiBlast_PDB
65.72
52%
-86
- C2 -
4LJ9
3
A:
[6-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
-------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
-
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
--
L
V
F
A
V
P
--