@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1879: (2015-12-11 )
MIKYQDDFYQAVNGEWAKTAVIPDDKPRTGGFSDLADDIEALMLSTTDKWLADENKPSDTILNHFIAFHKMTADYQKREEVGVSPVLPLIEEYKGLQSFSEFASKVAEYELEGKPNEFPFGVAPDFMNAQLNVLWAEAPGIILPDTTYYSEDNEKGKELLAFWRKSQEDLLPLFGLSEQEIKDILDKVLALDAKLAQYVLSREESSEYVKLYHPYNWEDFTKLAPELPLDAIFQKILGQKPDKVIVPEERFWTEFASDYYSESNWELLKADLILSAANAYNAYLTDDIRIKSGVYSRALSGTPQAMDKKKAAYYLASGPYNQALGLWYAGEKFSPEAKADVEHKIATMIDVYKSRLEKADWLAQSTREKAIMKLNVITPHIGYPEKLPETYTKKIIDPKLSLVENATNLDKISIAYGWSKWNKPVDRSEWHMPAHMVNAYYDPQQNQIVFPAAILQEPFYALEQSSSANYGGIGAVIAHEISHAFDTNGASFDEHGSLNNWWTDEDFEAFKKLTDKVVEQFDGLESYGAKVNGKLTVSENVADLGGVACALEAAQRESDFSARDFFINFATIWRMKARDEYMQMLASVDVHAPAQWRTNITVTNFEEFHKEFDVKDGDNMWRPVEKRVIIW
Atome Classification :
(20 SA)
-------------------------------------......-------...10.......-.20........30........40.---.......50.......----.60-.------..-----.....----70-..--......80.......------------.90........100-------.------.--..-------.-----------...-------------.110------.-......120------....----....----.130.......140-------..----.......150.......160--------.......170......----------.------.-.180.......190......---.200---.......210.------------------.------.....220------..------..---..-.230....-----.--..------240---..------....-----.250---....-..--------..260.......270-.......280.......290.---......-300.......310.....--..------320.....-..330.------------------..-------....340-----.........350.....----------------------..360.......370-----------.......-----380---...------...-------..390--.....------..400-------------..-------.......410....-...------420.......430.----......440-......--.450.......------460.......470........480.......-------490.......500-......--..510..----.....-520-----...---.---..---.-.530---.........540.......550....-------.---.-------------.----------560-----------.-.-.---------------------.-------------...----------..570.......----580.....------------..590.......600.......610.......620.......630----------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------MIK
Y
Q
D
-------
D
F
Y
Q
AVNGEWA
K
-
T
AVIPDDKPRTGG
F
S
D
L
A
D
D
I
E
A
L
---
M
L
ST
T
D
K
W
LADENK
P
S
----
D
T
I
-
L
------
N
H
-----
F
I
A
F
H
----
K
M
-
T
A
--
D
Y
Q
K
R
E
EVGVS
P
V
L
P
------------
L
I
E
E
Y
K
G
L
Q
S
F
S
---------
E
------
F
--
A
S
-------
K
-----------
V
A
E
-------------
Y
E
LE------G-KPNEFPF--------GVAP----DFMN----A
Q
L
N
V
L
W
AEAP
G
---------
I
I----LPDTTYYSEDNE
K
G
K
E
L
L
A
F
--------
W
R
KSQEDL--LPLFGL----------
S
------
E
-
Q
E
I
K
D
I
L
D
K
V
L
A
L
D
A
K
L
A
Q
Y
---
V
L
S
R
---EESS
E
Y
V
K
L
YH------------------P------Y
N
W
E
D
F
T
K
------LA------PE---L
P
-
L
D
A
I
F
Q
K
I
-----L--GQ------KP
D
---
K
V
------IV
P
E
-----
E
R
F
----
W
T
E
F
-
A
S
--------
D
YYSESN
W
E
L
L
K
A
D
L
-
I
L
SAANAY
N
A
YLTD
D
I
R
IKSG---
V
Y
S
RAL-SGT
P
Q
A
M
DKK
K
A
A
Y
Y
L
AS--GP------YNQ
A
L
G
L
W
-YAGEKF------------------SP-------EAKA
D
-------
V
E
H
K
I
A
T
M
I
D
V
Y
K
S
R
L
E
----------------------
K
A
D
W
L
A
Q
S
T
RE
K
A
I
M
-----------
K
L
N
VITP-----HI----G
Y
P
------
E
KL-------
P
E
T
Y
T
--
K
K
IID------P
K
L
---------------
S
L
-------
V
ENATNL
D
K
I
S
I
A
Y-GWS------KWNKPVDRSEWHM
P
----
A
H
M
V
N
A
YYD-PQQ
N
Q
I
--
V
F
P
A
A
I
L
QE
P
F
------
Y
A
L
EQSSSANY-G
G
I
G
A
V
I
A
H
E
I
S
H
AFDTNG-------ASFDEHGSLNNW--WT
D
E
D
F
--
E
A
F
K
K
L
T
----
D
K
V
V
E
-
Q
F------D
G
L
---
E
---
S
Y---G-AK-----VN
G
K
L
T
VSE
N
V
A
D
L
G
G
V
A
C
A
L
E
A
A
QR-------E---S-------------D----------F-------------S-A-
R
---------------------
D
-------------
F
F
I
----------
N
F
A
T
I
W
R
M
K
A
R
D
----
E
Y
M
Q
M
L
A
S------------VDVHAPA
Q
W
RTN
I
T
VT
N
F
E
E
F
H
K
EFDVKDGDNMWRP
V
E
K
R
V
IIW-----------------------------------
28
Fugue
99.75
33%
-69
- C6 -
4IUW
16
?
A:
[4-633]
-------------------------------------
L
P
R
I
Q
D
-------
D
L
Y
L
A
V
N
G
E
W
Q
A
-
K
T
P
I
P
P
D
K
S
V
V
S
A
D
S
N
L
T
D
D
I
R
Q
K
---
L
V
A
D
L
S
T
---
M
T
K
T
A
K
----
T
L
P
-
L
------
Q
Y
-----
A
A
R
L
F
----
A
K
-
A
N
--
D
Q
T
R
R
Q
Q
L
G
I
E
P
V
R
D
------------
R
I
S
F
L
M
A
L
T
T
L
D
---------
Q
------
F
--
R
S
-------
A
-----------
M
P
K
-------------
L
V
A
D
------
Q
-
Y
V
L
P
I
S
P
--------
Y
V
D
A
----
D
M
H
D
----
A
E
H
N
I
L
N
L
G
G
P
D
---------
T
I
----
L
P
D
A
A
M
Y
N
Q
E
D
A
E
N
A
A
D
L
A
A
--------
W
S
Q
M
A
A
A
M
--
L
A
A
V
G
F
----------
S
------
Q
-
T
D
Q
T
A
Y
V
E
A
A
K
R
F
D
R
R
L
A
D
Y
---
V
P
A
N
---
V
D
L
A
V
D
S
T
Y
D
N
------------------
P
------
L
S
W
Q
A
F
E
D
------
A
A
------
G
Y
---
L
G
-
I
P
Q
A
F
A
T
Y
-----
M
--
P
Q
------
T
P
A
---
K
V
------
N
A
V
V
-----
P
A
Y
-----
L
P
H
-
L
S
--------
K
L
L
T
P
D
N
Y
S
E
W
H
A
W
M
-
V
I
N
E
L
L
T
C
A
T
Y
L
S
D
D
L
R
Q
L
A
G
---
Q
Y
D
R
F
L
-
A
G
Q
P
E
A
S
S
W
T
K
H
A
F
G
I
A
N
--
E
Y
------
F
D
D
V
I
G
Q
Y
-
Y
G
Q
T
Y
F
------------------
G
A
-------
D
A
K
A
D
-------
V
T
A
M
V
K
Q
I
L
A
Q
Y
R
V
Q
L
E
----------------------
N
N
T
W
L
S
P
A
T
K
Q
K
A
M
R
-----------
K
L
A
T
M
Q
V
-----
K
M
----
G
Y
P
------
A
R
L
-------
F
S
L
Y
D
--
H
L
S
V
D
------
V
D
D
---------------
D
L
-------
L
T
A
I
L
K
L
S
A
Q
T
Q
A
F
-
W
F
K
------
Q
L
G
Q
T
V
D
R
N
Q
W
N
M
P
----
G
H
L
V
N
A
S
Y
D
-
P
L
K
N
D
I
--
T
F
P
A
G
I
L
Q
P
P
Y
------
Y
S
L
K
W
T
R
A
E
N
L
-
G
G
T
G
A
T
I
G
H
E
I
S
H
S
F
D
N
N
G
-------
A
L
Y
D
E
Y
G
N
L
H
N
W
--
W
T
P
A
D
K
--
Q
A
F
D
Q
L
V
----
K
A
M
A
A
-
Q
F
------
D
G
R
---
D
---
Y
E
---
G
-
V
K
-----
V
N
G
T
L
T
V
S
E
N
M
A
D
N
A
G
M
D
V
A
L
A
L
L
G
D
-------
Q
---
P
-------------
D
----------
V
-------------
K
-
D
L
Q
---------------------
A
-------------
F
F
I
----------
T
Y
A
R
S
W
A
T
K
M
R
P
----
E
R
A
K
T
V
L
R
------------
Q
D
V
H
A
P
A
T
L
R
V
N
V
P
V
Q
N
F
P
A
W
Y
Q
A
F
N
V
Q
P
Q
D
G
M
Y
R
Q
P
Q
K
R
L
T
I
W
HQ---------------------------------
1
PsiBlast_PDB
97.43
33%
-73
- C6 -
4IUW
16
?
A:
[6-631]
---------------------------------------
R
I
Q
D
-------
D
L
Y
L
A
V
N
G
E
W
Q
A
-
K
T
P
I
P
P
D
K
S
V
V
S
A
D
S
N
L
T
D
D
I
R
Q
K
---
L
V
A
D
----
L
S
T
M
T
K
T
A
----
K
T
L
P
L
------
Q
Y
-----
A
A
R
L
F
----
A
K
-
A
N
--
D
Q
T
R
R
Q
Q
L
G
I
E
P
V
R
D
------------
R
I
S
F
L
M
A
L
T
T
L
D
---------
Q
------
F
--
R
S
-------
A
-----------
M
P
K
-------------
L
V
A
D
-----------
Q
Y
V
L
--------
P
I
S
P
Y
V
D
A
D
M
H
D
----
A
E
H
N
I
L
N
L
G
G
P
D
---------
T
I
----
L
P
D
A
A
M
Y
N
Q
E
D
A
E
N
A
A
D
L
A
A
--------
W
S
Q
M
A
A
A
M
--
L
A
A
V
G
F
----------
S
------
Q
-
T
D
Q
T
A
Y
V
E
A
A
K
R
F
D
R
R
L
A
D
Y
---
V
P
A
N
---
V
D
L
A
V
D
S
T
Y
D
N
------------------
P
------
L
S
W
Q
A
F
E
D
------
A
A
------
G
Y
---
L
G
-
I
P
Q
A
F
A
T
Y
-----
M
--
P
Q
------
T
P
A
---
K
V
N
A
----
V
V
P
A
YL---
P
H
L
----
S
K
L
L
-
T
P
--------
D
N
Y
S
E
W
H
A
W
M
V
I
N
E
L
-
L
T
C
A
T
-----
Y
L
S
D
D
L
R
Q
L
A
G
---
Q
Y
D
R
F
L
-
A
G
Q
P
E
A
S
S
W
T
K
H
A
F
G
I
A
N
--
E
Y
------
F
D
D
V
I
G
Q
Y
-
Y
G
Q
T
Y
F
------------------
G
A
-------
D
A
K
A
D
-------
V
T
A
M
V
K
Q
I
L
A
Q
Y
R
V
Q
L
E
----------------------
N
N
T
W
L
S
P
A
T
K
Q
K
A
M
R
-----------
K
L
A
T
M
Q
V
-----
K
M
----
G
Y
P
------
A
R
L
-------
F
S
L
Y
D
--
H
L
S
V
D
------
V
D
D
---------------
D
L
-------
L
T
A
I
L
K
L
S
A
Q
T
Q
A
F
-
W
F
K
------
Q
L
G
Q
T
V
D
R
N
Q
W
N
M
P
----
G
H
L
V
N
A
S
Y
D
-
P
L
K
N
D
I
--
T
F
P
A
G
I
L
Q
P
P
Y
------
Y
S
L
K
W
T
R
A
E
N
L
-
G
G
T
G
A
T
I
G
H
E
I
S
H
S
F
D
N
N
G
-------
A
L
Y
D
E
Y
G
N
L
H
N
W
--
W
T
P
A
D
K
--
Q
A
F
D
Q
L
V
----
K
A
M
A
A
-
Q
F
------
D
G
R
---
D
---
Y
E
---
G
-
V
K
-----
V
N
G
T
L
T
V
S
E
N
M
A
D
N
A
G
M
D
V
A
L
A
L
L
G
D
-------
Q
---
P
-------------
D
----------
V
-------------
K
D
L
-
Q
---------------------
A
-------------
F
F
I
----------
T
Y
A
R
S
W
A
T
K
M
R
P
----
E
R
A
K
T
V
L
R
------------
Q
D
V
H
A
P
A
T
L
R
V
N
V
P
V
Q
N
F
P
A
W
Y
Q
A
F
N
V
Q
P
Q
D
G
M
Y
R
Q
P
Q
K
R
L
T
I
W
-----------------------------------
2
PsiBlast_PDB
90.90
29%
-53
- C6 -
3ZUK
23
?
A:
[57-698]
-----------------------------------------
Q
D
-------
D
L
F
G
H
V
N
G
R
W
L
A
-
E
H
E
I
P
A
D
R
A
T
D
G
A
F
R
S
L
F
D
R
A
E
T
Q
V
R
D
L
I
I
Q
A
S
Q
A
G
A
A
V
G
T
D
A
----
Q
R
I
-
G
------
D
L
-----
Y
A
S
F
---------
L
--
D
E
E
A
V
E
R
A
G
V
Q
P
L
H
D
------------
E
L
A
T
I
D
S
A
A
D
A
T
---------
E
------
L
--
A
A
-------
A
-----------
L
G
T
-------------
L
Q
R
A
------
G
-
V
G
G
G
I
G
V
--------
Y
V
D
T
----
D
S
K
D
----
S
T
R
Y
L
V
H
F
T
Q
S
G
---------
I
G
----
L
P
D
E
S
Y
Y
-
R
D
E
Q
H
A
A
V
L
A
A
Y
--------
P
G
H
I
A
R
M
F
--
G
L
V
Y
G
G
----------
E
------
S
-
R
D
H
A
K
T
A
D
R
I
V
A
L
E
T
K
L
A
D
A
HWD
V
V
K
R
---
R
D
A
D
L
------------------------
G
------
Y
N
L
R
T
F
A
Q
------
L
Q
------
T
E
-------
G
A
G
F
D
W
V
S
W
V
T
A
L
--
G
S
------
A
P
D
AMT
E
L
------
V
V
R
Q
-----
P
D
Y
----
L
V
T
F
-
A
S
L
W
A
S
VN
V
E
D
W
K
C
W
A
R
W
R
L
I
R
A
-----
R
A
P
W
L
T
R
A
L
V
A
E
D
F
E
F
-------
Y
G
R
T
L
-
T
G
A
Q
Q
L
R
D
R
W
K
R
G
V
S
L
V
E
--
N
L
------
M
G
D
A
V
G
K
L
-
Y
V
Q
R
H
F
----------------------------
A
K
S
R
-------
I
D
T
L
V
D
N
L
Q
E
A
Y
R
I
S
I
S
----------------------
E
L
D
W
M
T
P
Q
T
R
Q
R
A
L
A
-----------
K
L
N
K
F
T
A
-----
K
V
----
G
Y
P
------
I
K
W
-------
R
D
-
Y
S
--
K
L
A
I
D
-------
R
D
---------------
D
L
-------
Y
G
N
V
Q
R
G
Y
A
V
N
H
D
R
-
E
L
A
------
K
L
F
G
P
V
D
R
D
E
W
F
M
T
----
P
Q
T
V
N
A
Y
Y
N
-
P
G
M
N
E
I
--
V
F
P
A
A
I
L
Q
P
P
F
------
F
D
P
Q
A
D
E
A
A
N
Y
-
G
G
I
G
A
V
I
G
H
E
I
G
H
G
F
D
D
Q
G
-------
A
K
Y
D
G
D
G
N
L
V
D
W
--
W
T
D
D
D
R
--
T
E
F
A
A
R
T
----
K
A
L
I
E
-
Q
Y
H
A
YTPR
D
L
V
---
D
---
H
P
---
G
P
P
H
-----
V
Q
G
A
F
T
I
G
E
N
I
G
D
L
G
G
L
S
I
A
L
L
A
Y
Q
L
-------
S
---
L
-------------
N
GNPAPVIDGL
T
-------------
G
-
M
-
Q
---------------------
R
-------------
V
F
F
----------
G
W
A
Q
I
W
R
T
K
S
R
A
----
A
E
A
I
R
R
L
A
------------
V
D
P
H
S
P
P
E
F
R
C
N
G
V
V
R
N
V
D
A
F
Y
Q
A
F
D
V
T
E
D
D
A
L
F
L
D
P
Q
R
R
V
R
I
W
-----------------------------------
19
HHSearch
90.79
25%
-70
- C6 -
3DWB
3
ECE1_HUMAN
A:
[18-670]
-------------------------------------
T
V
D
P
C
H
-------
D
F
F
S
Y
A
C
G
G
W
I
K
-
A
N
P
V
P
D
G
H
S
R
W
G
T
F
S
N
L
W
E
H
N
Q
A
I
---
I
K
H
L
L
E
N
S
T
A
----
S
V
----
S
E
A
-
E
------
R
K
-----
A
Q
V
Y
Y
----
R
A
-
C
M
--
N
E
T
R
I
E
E
L
R
A
K
P
L
M
E
------------
L
I
E
R
L
G
G
W
N
I
T
G
---------
P
W
A
K
DN-
F
--
Q
D
-------
T
-----------
L
Q
V
-------------
V
T
A
H
------
Y
R
T
S
P
F
F
S
V
--------
Y
V
S
A
----
D
S
K
N
----
S
N
S
N
V
I
Q
V
D
Q
S
G
---------
L
G
----
L
P
S
R
D
Y
Y
L
N
K
-
T
E
N
E
K
V
L
T
G
--------
Y
L
N
Y
M
V
Q
L
--
G
K
L
L
G
G
----------
G
------
D
E
E
A
I
R
P
Q
M
Q
Q
I
L
D
F
E
T
A
L
A
N
I
---
T
I
P
Q
---
E
K
R
R
D
E
E
L
I
Y
H
------------------
K
------
V
T
A
A
E
L
Q
T
------
L
A
------
P
A
---
I
N
-
W
L
P
F
L
N
T
I
-----
F
--
Y
P
V
E
I
N
--
E
S
E
---
P
I
------
V
V
Y
D
-----
K
E
Y
----
L
E
Q
I
-
S
---------
T
L
I
N
T
T
D
R
C
L
L
N
N
Y
M
-
I
W
N
L
V
R
K
T
S
S
F
L
D
Q
R
F
Q
D
A
D
E
---
K
F
M
E
V
M
----------
W
K
F
C
V
S
D
T
E
--
N
N
------
L
G
F
A
L
G
P
M
-
F
V
K
A
T
F
------------------
A
E
-------
D
S
K
S
I
-------
A
T
E
I
I
L
E
I
K
K
A
F
E
E
S
L
S
----------------------
T
L
K
W
M
D
E
E
T
R
K
S
A
K
E
-----------
K
A
D
A
I
Y
N
-----
M
I
----
G
Y
P
------
N
F
I
M
D
P
K
E
L
-
D
K
V
F
N
--
D
Y
T
A
V
------
P
-
D
---------------
L
Y
-------
F
E
N
A
M
R
F
F
N
F
S
W
R
V
-
T
A
D
------
Q
L
R
K
A
P
N
R
D
Q
W
S
M
T
----
P
P
M
V
N
A
Y
Y
S
-
P
T
K
N
E
I
--
V
F
P
A
G
I
L
Q
A
P
F
------
Y
T
R
S
S
P
K
A
L
N
F
-
G
G
I
G
V
V
V
G
H
E
L
T
H
A
F
D
D
Q
G
-------
R
E
Y
D
K
D
G
N
L
R
P
W
--
W
K
N
S
S
V
--
E
A
F
K
R
Q
T
----
E
C
M
V
E
-
Q
Y
------
S
N
Y
---
S
---
V
N
---
G
-
E
P
-----
V
N
G
R
H
T
L
G
E
N
I
A
D
N
G
G
L
K
A
A
Y
R
A
Y
Q
N
-------
W
---
V
K
K
NGA
E
H
S
L
P
TLG
L
----------
T
-------------
N
-
N
-
Q
---------------------
L
-------------
F
F
L
----------
G
F
A
Q
V
W
C
S
V
R
T
P
----
E
S
S
H
E
G
L
I
------------
T
D
P
H
S
P
S
R
F
R
V
I
G
S
L
S
N
S
K
E
F
S
E
H
F
R
C
P
P
G
S
P
M
--
N
P
P
H
K
C
E
V
W
-----------------------------------
18
HHSearch
90.03
27%
-64
- C6 -
1R1H
5
NEP_HUMAN
A:
[22-696]
-------------------------------------
T
T
E
P
C
T
-------
D
F
F
K
Y
A
C
G
G
W
L
K
-
R
N
V
I
P
E
T
S
S
R
Y
G
N
F
D
I
L
R
D
E
L
E
V
V
---
L
K
D
V
L
Q
E
P
K
T
----
E
D
----
I
V
A
-
V
------
Q
K
-----
A
K
A
L
Y
----
R
S
-
C
I
--
N
E
S
A
I
D
S
R
G
G
E
P
L
L
K
------------
L
L
P
D
I
Y
G
W
P
V
A
T
ENWEQKYGA
S
------
W
T
A
E
K
-------
A
-----------
I
A
Q
-------------
L
N
S
K
------
Y
G
K
K
V
L
I
N
L
--------
F
V
G
T
----
D
D
K
N
----
S
V
N
H
V
I
H
I
D
Q
P
R
---------
L
G
----
L
P
S
R
D
Y
Y
E
C
T
-
G
I
Y
K
E
A
C
T
A
--------
Y
V
D
F
M
I
S
V
--
A
R
L
I
R
Q
----------
E
E
R
L
P
I
D
E
-
N
Q
L
A
L
E
M
N
K
V
M
E
L
E
K
E
I
A
N
A
---
T
A
K
P
---
E
D
R
N
D
P
M
L
L
Y
N
------------------
K
------
M
T
L
A
Q
I
Q
N
------
N
F
S
L
E
I
NG
K
P
---
F
S
-
W
L
N
F
T
N
E
I
-----
M
--
S
T
VN
I
S
I
T
N
E
E
---
D
V
------
V
V
Y
A
-----
P
E
Y
----
L
T
K
L
-
K
---------
P
I
L
T
K
Y
S
A
R
D
L
Q
N
L
M
-
S
W
R
F
I
M
D
L
V
S
S
L
S
R
T
Y
K
E
S
R
N
---
A
F
R
K
A
L
-
Y
G
T
T
S
E
T
A
T
W
R
R
C
A
N
Y
V
N
--
G
N
------
M
E
N
A
V
G
R
L
-
Y
V
E
A
A
F
------------------
A
G
-------
E
S
K
H
V
-------
V
E
D
L
I
A
Q
I
R
E
V
F
I
Q
T
L
D
----------------------
D
L
T
W
M
D
A
E
T
K
K
R
A
E
E
-----------
K
A
L
A
I
K
E
-----
R
I
----
G
Y
P
------
D
D
I
V
S
N
D
N
K
L
N
N
E
Y
L
--
E
L
N
Y
K
------
E
-
D
---------------
E
Y
-------
F
E
N
I
I
Q
N
L
K
F
S
Q
S
K
-
Q
L
K
------
K
L
R
E
K
V
D
K
D
E
W
I
S
G
----
A
A
V
V
N
A
F
Y
S
-
S
G
R
N
Q
I
--
V
F
P
A
G
I
L
Q
P
P
F
------
F
S
A
Q
Q
S
N
S
L
N
Y
-
G
G
I
G
M
V
I
G
H
E
I
T
H
G
F
D
D
N
G
-------
R
N
F
N
K
D
G
D
L
V
D
W
--
W
T
Q
Q
S
A
--
S
N
F
K
E
Q
S
----
Q
C
M
V
Y
-
Q
Y
------
G
N
F
---
S
---
W
D
LAG
G
-
Q
H
-----
L
N
G
I
N
T
L
G
E
N
I
A
D
N
G
G
L
G
Q
A
Y
R
A
Y
Q
N
-------
Y
---
I
K
K
NGE
E
K
L
L
P
GLD
L
----------
N
-------------
H
-
K
-
Q
---------------------
L
-------------
F
F
L
----------
N
F
A
Q
V
W
C
G
T
Y
R
P
----
E
Y
A
V
N
S
I
K
------------
T
D
V
H
S
P
G
N
F
R
I
I
G
T
L
Q
N
S
A
E
F
S
E
A
F
H
C
R
K
N
S
Y
M
--
N
P
E
K
K
C
R
V
W
-----------------------------------
3
PsiBlast_PDB
89.41
26%
-54
- C6 -
3DWB
3
ECE1_HUMAN
A:
[24-669]
--------------------------------------------------
D
F
F
S
Y
A
C
G
G
W
I
K
-
A
N
P
V
P
D
G
H
S
R
W
G
T
F
S
N
L
W
E
H
N
Q
A
I
I
K
H
L
L
E
N
S
T
A
S
V
S
E
A
E
R
K
A
----
Q
-------------------
V
Y
Y
----
R
A
-
C
M
--
N
E
T
R
I
E
E
L
R
A
K
P
L
M
E
------------
L
I
E
R
L
G
G
W
N
I
T
G
---------
P
------
W
--
A
K
DN
F
Q
D
T
L
Q
-----------
V
V
T
-------------
A
H
Y
R
------
T
-
S
P
-
F
F
S
V
--------
Y
V
S
A
----
D
S
K
N
----
S
N
S
N
V
I
Q
V
D
Q
S
G
---------
L
G
----
L
P
S
R
D
Y
Y
L
N
K
T
E
N
E
K
V
L
T
G
Y
--------
L
N
Y
M
V
Q
L
G
--
K
L
L
G
G
G
----------
D
------
E
-
E
A
I
R
P
Q
M
Q
Q
I
L
D
F
E
T
A
L
A
N
I
---
T
I
P
Q
---
E
K
R
R
D
E
E
L
I
Y
H
------------------
K
------
V
T
A
A
E
L
Q
T
------
L
A
------
P
A
INW
L
P
F
L
N
T
I
F
Y
P
V
-----
E
--
I
N
------
E
S
E
---
P
I
------
V
V
Y
D
-----
K
E
Y
-----
L
E
Q
-
I
S
--------
T
L
I
N
T
T
D
R
C
L
L
N
N
Y
M
-
I
W
N
L
V
R
K
T
S
S
F
L
D
Q
R
F
Q
D
A
D
E
---
K
F
M
E
V
M
----------
W
K
F
C
V
S
D
T
E
--
N
N
------
L
G
F
A
L
G
P
M
-
F
V
K
A
T
F
------------------
A
E
-------
D
S
K
S
I
-------
A
T
E
I
I
L
E
I
K
K
A
F
E
E
S
L
S
----------------------
T
L
K
W
M
D
E
E
T
R
K
S
A
K
E
-----------
K
A
D
A
I
Y
N
-----
M
I
----
G
Y
P
N
F
I
M
D
P
K
E
L
-------
D
K
V
F
N
--
D
Y
T
A
V
------
P
D
L
---------------
Y
F
--------
E
N
A
M
R
F
F
N
F
S
W
R
V
-
T
A
D
------
Q
L
R
K
A
P
N
R
D
Q
W
S
M
T
----
P
P
M
V
N
A
Y
Y
S
-
P
T
K
N
E
I
--
V
F
P
A
G
I
L
Q
A
P
F
------
Y
T
R
S
S
P
K
A
L
N
F
-
G
G
I
G
V
V
V
G
H
E
L
T
H
A
F
D
D
Q
G
-------
R
E
Y
D
K
D
G
N
L
R
P
W
--
W
K
N
S
S
V
--
E
A
F
K
R
Q
T
----
E
C
M
V
E
-
Q
Y
------
S
N
Y
---
S
---
V
N
---
G
-
E
P
-----
V
N
G
R
H
T
L
G
E
N
I
A
D
N
G
G
L
K
A
A
Y
R
A
Y
Q
N
-------
W
---
V
-------------
K
----------
K
-------------
N
-
G
-
A
---------------------
E
H
S
L
P
TLGLT
N
N
Q
L
F
F
L
----------
G
F
A
Q
V
W
C
S
V
R
T
P
----
E
S
S
H
E
G
L
I
------------
T
D
P
H
S
P
S
R
F
R
V
I
G
S
L
S
N
S
K
E
F
S
E
H
F
R
C
P
P
G
S
P
M
N
P
P
H
K
C
E
V
W
-------------------------------------
27
Fugue
89.32
27%
-59
* C6 *
1DMT
6
NEP_HUMAN
A:
[1-696]
-----------------------GICKS
S
D
C
I
K
S
A
A
R
L
I
Q
N
M
D
ATTEPCT
D
F
F
K
Y
A
C
G
G
W
L
K
-
R
N
V
I
P
E
T
S
S
R
Y
G
N
F
D
I
L
R
D
E
L
E
V
V
---
L
K
D
V
L
Q
E
----
P
K
T
E
D
----
I
V
A
-
V
------
Q
K
-----
A
K
A
L
Y
----
R
S
-
C
I
--
N
E
S
A
I
D
S
R
G
G
E
P
L
L
K
------------
L
L
P
D
I
Y
G
W
P
V
A
T
---------
E
------
N
--
W
E
-------
Q
KYGASWT
A
E
K
A
I
A
Q
-------------
L
N
S
K
Y-----
G
-
K
K
V
L
I
N
L
--------
F
V
G
T
----
D
D
K
N
----
S
V
N
H
V
I
H
I
D
Q
P
R
---------
L
G
----
L
P
S
R
D
Y
Y
E
C
T
G
-
I
Y
K
E
A
C
T
A
--------
Y
V
D
F
M
I
S
V
--
A
R
L
I
R
Q
E
E
RLPI----
D
------
E
-
N
Q
L
A
L
E
M
N
K
V
M
E
L
E
K
E
I
A
N
A
---
T
A
K
P
---
E
D
R
N
D
P
M
L
L
Y
N
------------------
K
------
M
T
L
A
Q
I
Q
N
N
F
S
L
E
I
N
G
------
K
P
---
F
S
-
W
L
N
F
T
N
E
I
-----
M
--
S
T
VN
I
S
I
T
N
E
E
---
D
V
------
V
V
Y
A
-----
P
E
Y
----
L
T
K
L
-
K
P
--------
I
L
-
T
K
Y
S
A
R
D
L
Q
N
L
M
-
S
W
R
F
I
M
D
L
V
S
S
L
S
R
T
Y
K
E
S
R
N
---
A
F
R
K
A
L
-
Y
G
T
T
S
E
T
A
T
W
R
R
C
A
N
Y
V
N
--
G
N
------
M
E
N
A
V
G
R
L
-
Y
V
E
A
A
F
------------------
A
G
-------
E
S
K
H
V
-------
V
E
D
L
I
A
Q
I
R
E
V
F
I
Q
T
L
D
----------------------
D
L
T
W
M
D
A
E
T
K
K
R
A
E
E
-----------
K
A
L
A
I
K
E
-----
R
I
----
G
Y
P
------
D
D
I
-------
V
S
N
D
N
--
K
L
N
N
E
Y
L
E
L
N
Y
K
E
D
---------------
E
Y
-------
F
E
N
I
I
Q
N
L
K
F
S
Q
S
K
-
Q
L
K
------
K
L
R
E
K
V
D
K
D
E
W
I
S
G
----
A
A
V
V
N
A
F
Y
S
-
S
G
R
N
Q
I
--
V
F
P
A
G
I
L
Q
P
P
F
------
F
S
A
Q
Q
S
N
S
L
N
Y
-
G
G
I
G
M
V
I
G
H
E
I
T
H
G
F
D
D
N
G
-------
R
N
F
N
K
D
G
D
L
V
D
W
--
W
T
Q
Q
S
A
--
S
N
F
K
E
Q
S
----
Q
C
M
V
Y
-
Q
Y
------
G
N
F
SWD
L
---
A
G
---
G
-
Q
H
-----
L
N
G
I
N
T
L
G
E
N
I
A
D
N
G
G
L
G
Q
A
Y
R
A
Y
Q
N
-------
Y
---
I
-------------
K
----------
K
NGE
E
K
L
L
P
GLDLN
H
-
K
-
Q
---------------------
L
-------------
F
F
L
----------
N
F
A
Q
V
W
C
G
T
Y
R
P
----
E
Y
A
V
N
S
I
K
------------
T
D
V
H
S
P
G
N
F
R
I
I
G
T
L
Q
N
S
A
E
F
S
E
A
F
H
C
R
K
N
S
Y
M
N
P
E
--
K
K
C
R
V
W
-----------------------------------
4
PsiBlast_PDB
88.05
27%
-56
- C6 -
1DMT
6
NEP_HUMAN
A:
[28-696]
--------------------------------------------------
D
F
F
K
Y
A
C
G
G
W
L
K
-
R
N
V
I
P
E
T
S
S
R
Y
G
N
F
D
I
L
R
D
E
L
E
V
V
---
L
-----
K
D
V
L
Q
E
P
K
T
E
----
D
I
V
A
V
------
Q
K
-----
A
K
A
L
Y
----
R
S
-
C
I
--
N
E
S
A
I
D
S
R
G
G
E
P
L
L
K
------------
L
L
P
D
I
Y
G
W
P
V
A
T
---------
E
NWEQKY
G
--
A
S
-------
W
-----------
T
A
E
-------------
K
A
I
A
Q
L
N
SKY
G
-
K
K
V
L
I
N
L
--------
F
V
G
T
----
D
D
K
N
----
S
V
N
H
V
I
H
I
D
Q
P
R
---------
L
G
----
L
P
S
R
D
Y
Y
E
C
T
G
I
Y
K
E
A
C
T
A
Y
V
D
F
M
I
S
V
A
R
L
I
R
Q
E
E
R
--
L
P
I
-------------
D
------
E
-
N
Q
L
A
L
E
M
N
K
V
M
E
L
E
K
E
I
A
N
A
---
T
A
K
P
---
E
D
R
N
D
P
M
L
L
Y
N
K
M
T
L
A
Q
I
Q
N
N
F
S
L
E
I
NGK
P
------
F
S
W
L
N
F
T
N
---------------
E
---
I
--
M
S
T
V
N
I
S
I
-----
T
--
N
E
------
E
D
V
---
V
V
------
Y
A
P
E
Y
L
T
K
L
K
P
I
----
L
T
K
Y
S
A
R
--------
D
L
Q
N
L
M
S
W
R
F
I
-
M
D
L
-
V
S
S
L
S
R
T
Y
--------
K
E
S
R
N
---
A
F
R
K
A
L
-
Y
G
T
T
S
E
T
A
T
W
R
R
C
A
N
Y
V
N
--
G
N
------
M
E
N
A
V
G
R
L
-
Y
V
E
A
A
F
------------------
A
G
-------
E
S
K
H
V
-------
V
E
D
L
I
A
Q
I
R
E
V
F
I
Q
T
L
D
----------------------
D
L
T
W
M
D
A
E
T
K
K
R
A
E
E
-----------
K
A
L
A
I
K
E
-----
R
I
----
G
Y
P
------
D
D
I
-------
V
S
N
-
D
--
N
K
L
N
N
------
E
Y
L
---------------
E
L
N
Y
K
EDE
Y
F
E
N
I
I
Q
N
L
K
F
S
Q
S
K
-
Q
L
K
------
K
L
R
E
K
V
D
K
D
E
W
I
S
G
----
A
A
V
V
N
A
F
Y
S
-
S
G
R
N
Q
I
--
V
F
P
A
G
I
L
Q
P
P
F
------
F
S
A
Q
Q
S
N
S
L
N
Y
-
G
G
I
G
M
V
I
G
H
E
I
T
H
G
F
D
D
N
G
-------
R
N
F
N
K
D
G
D
L
V
D
W
--
W
T
Q
Q
S
A
--
S
N
F
K
E
Q
S
----
Q
C
M
V
Y
-
Q
Y
------
G
N
F
---
S
WDL
A
G
---
G
-
Q
H
-----
L
N
G
I
N
T
L
G
E
N
I
A
D
N
G
G
L
G
Q
A
Y
R
A
Y
Q
N
Y
I
K
K
NGE
E
---
K
-------------
L
----------
L
-------------
P
-
G
-
L
---------------------
D
LN
H
K
Q
L
-------
F
F
L
----------
N
F
A
Q
V
W
C
G
T
Y
R
P
----
E
Y
A
V
N
S
I
K
------------
T
D
V
H
S
P
G
N
F
R
I
I
G
T
L
Q
N
S
A
E
F
S
E
A
F
H
C
R
--
K
N
S
Y
M
N
P
E
K
K
C
R
V
W
-----------------------------------
7
PsiBlast_PDB
87.82
27%
-56
- C6 -
1R1J
5
NEP_HUMAN
A:
[28-696]
--------------------------------------------------
D
F
F
K
Y
A
C
G
G
W
L
K
-
R
N
V
I
P
E
T
S
S
R
Y
G
N
F
D
I
L
R
D
E
L
E
V
V
---
L
-----
K
D
V
L
Q
E
P
K
T
E
----
D
I
V
A
V
------
Q
K
-----
A
K
A
L
Y
----
R
S
-
C
I
--
N
E
S
A
I
D
S
R
G
G
E
P
L
L
K
------------
L
L
P
D
I
Y
G
W
P
V
A
T
---------
E
NWEQKY
G
--
A
S
-------
W
-----------
T
A
E
-------------
K
A
I
A
Q
L
N
S
KY
G
-
K
K
V
L
I
N
L
--------
F
V
G
T
----
D
D
K
N
----
S
V
N
H
V
I
H
I
D
Q
P
R
---------
L
G
----
L
P
S
R
D
Y
Y
E
C
T
G
I
Y
K
E
A
C
T
A
Y
V
D
F
M
I
S
V
A
R
L
I
R
Q
E
E
R
--
L
P
I
-------------
D
------
E
-
N
Q
L
A
L
E
M
N
K
V
M
E
L
E
K
E
I
A
N
A
---
T
A
K
P
---
E
D
R
N
D
P
M
L
L
Y
N
K
M
T
L
A
Q
I
Q
N
N
F
S
L
E
I
NGK
P
------
F
S
W
L
N
F
T
N
---------------
E
---
I
--
M
S
T
V
N
I
S
I
-----
T
--
N
E
------
E
D
V
---
V
V
------
Y
A
P
E
Y
L
T
K
L
K
P
I
----
L
T
K
Y
S
A
R
--------
D
L
Q
N
L
M
S
W
R
F
I
-
M
D
L
-
V
S
S
L
S
R
T
Y
--------
K
E
S
R
N
---
A
F
R
K
A
L
-
Y
G
T
T
S
E
T
A
T
W
R
R
C
A
N
Y
V
N
--
G
N
------
M
E
N
A
V
G
R
L
-
Y
V
E
A
A
F
------------------
A
G
-------
E
S
K
H
V
-------
V
E
D
L
I
A
Q
I
R
E
V
F
I
Q
T
L
D
----------------------
D
L
T
W
M
D
A
E
T
K
K
R
A
E
E
-----------
K
A
L
A
I
K
E
-----
R
I
----
G
Y
P
------
D
D
I
-------
V
S
N
-
D
--
N
K
L
N
N
------
E
Y
L
---------------
E
L
N
Y
K
EDE
Y
F
E
N
I
I
Q
N
L
K
F
S
Q
S
K
-
Q
L
K
------
K
L
R
E
K
V
D
K
D
E
W
I
S
G
----
A
A
V
V
N
A
F
Y
S
-
S
G
R
N
Q
I
--
V
F
P
A
G
I
L
Q
P
P
F
------
F
S
A
Q
Q
S
N
S
L
N
Y
-
G
G
I
G
M
V
I
G
H
E
I
T
H
G
F
D
D
N
G
-------
R
N
F
N
K
D
G
D
L
V
D
W
--
W
T
Q
Q
S
A
--
S
N
F
K
E
Q
S
----
Q
C
M
V
Y
-
Q
Y
------
G
N
F
---
S
WDL
A
G
---
G
-
Q
H
-----
L
N
G
I
N
T
L
G
E
N
I
A
D
N
G
G
L
G
Q
A
Y
R
A
Y
Q
N
Y
I
K
K
NGE
E
---
K
-------------
L
----------
L
-------------
P
-
G
-
L
---------------------
D
LN
H
K
Q
L
-------
F
F
L
----------
N
F
A
Q
V
W
C
G
T
Y
R
P
----
E
Y
A
V
N
S
I
K
------------
T
D
V
H
S
P
G
N
F
R
I
I
G
T
L
Q
N
S
A
E
F
S
E
A
F
H
C
R
--
K
N
S
Y
M
N
P
E
K
K
C
R
V
W
-----------------------------------
10
PsiBlast_PDB
87.27
27%
-58
- C6 -
2YB9
2
NEP_HUMAN
A:
[28-696]
--------------------------------------------------
D
F
F
K
Y
A
C
G
G
W
L
K
-
R
N
V
I
P
E
T
S
S
R
Y
G
N
F
D
I
L
R
D
E
L
E
V
V
---
L
-----
K
D
V
L
Q
E
P
K
T
E
----
D
I
V
A
V
------
Q
K
-----
A
K
A
L
Y
----
R
S
-
C
I
--
N
E
S
A
I
D
S
R
G
G
E
P
L
L
K
------------
L
L
P
D
I
Y
G
W
P
V
A
T
---------
E
NWEQKY
G
--
A
S
-------
W
-----------
T
A
E
-------------
K
A
I
A
Q
L
N
SKY
G
-
K
K
V
L
I
N
L
--------
F
V
G
T
----
D
D
K
N
----
S
V
N
H
V
I
H
I
D
Q
P
R
---------
L
G
----
L
P
S
R
D
Y
Y
E
C
T
G
I
Y
K
E
A
C
T
A
Y
V
D
F
M
I
S
V
A
R
L
I
R
Q
E
E
R
--
L
P
I
-------------
D
------
E
-
N
Q
L
A
L
E
M
N
K
V
M
E
L
E
K
E
I
A
N
A
---
T
A
K
P
---
E
D
R
N
D
P
M
L
L
Y
N
K
M
T
L
A
Q
I
Q
N
N
F
S
L
E
I
NGK
P
------
F
S
W
L
N
F
T
N
---------------
E
---
I
--
M
S
T
V
N
I
S
I
-----
T
--
N
E
------
E
D
V
---
V
V
------
Y
A
P
E
Y
L
T
K
L
K
P
I
----
L
T
K
Y
S
A
R
--------
D
L
Q
N
L
M
S
W
R
F
I
-
M
D
L
-
V
S
S
L
S
R
T
Y
--------
K
E
S
R
N
---
A
F
R
K
A
L
-
Y
G
T
T
S
E
T
A
T
W
R
R
C
A
N
Y
V
N
--
G
N
------
M
E
N
A
V
G
R
L
-
Y
V
E
A
A
F
------------------
A
G
-------
E
S
K
H
V
-------
V
E
D
L
I
A
Q
I
R
E
V
F
I
Q
T
L
D
----------------------
D
L
T
W
M
D
A
E
T
K
K
R
A
E
E
-----------
K
A
L
A
I
K
E
-----
R
I
----
G
Y
P
------
D
D
I
-------
V
S
N
-
D
--
N
K
L
N
N
------
E
Y
L
---------------
E
L
N
Y
K
EDE
Y
F
E
N
I
I
Q
N
L
K
F
S
Q
S
K
-
Q
L
K
------
K
L
R
E
K
V
D
K
D
E
W
I
S
G
----
A
A
V
V
N
A
F
Y
S
-
S
G
R
N
Q
I
--
V
F
P
A
G
I
L
Q
P
P
F
------
F
S
A
Q
Q
S
N
S
L
N
Y
-
G
G
I
G
M
V
I
G
H
E
I
T
H
G
F
D
D
N
G
-------
R
N
F
N
K
D
G
D
L
V
D
W
--
W
T
Q
Q
S
A
--
S
N
F
K
E
Q
S
----
Q
C
M
V
Y
-
Q
Y
------
G
N
F
---
S
WDL
A
G
---
G
-
Q
H
-----
L
N
G
I
N
T
L
G
E
N
I
A
D
N
G
G
L
G
Q
A
Y
R
A
Y
Q
N
Y
I
K
K
NGE
E
---
K
-------------
L
----------
L
-------------
P
-
G
-
L
---------------------
D
LN
H
K
Q
L
-------
F
F
L
----------
N
F
A
Q
V
W
C
G
T
Y
R
P
----
E
Y
A
V
N
S
I
K
------------
T
D
V
H
S
P
G
N
F
R
I
I
G
T
L
Q
N
S
A
E
F
S
E
A
F
H
C
R
--
K
N
S
Y
M
N
P
E
K
K
C
R
V
W
-----------------------------------
5
PsiBlast_PDB
87.26
27%
-57
- C6 -
1R1H
5
NEP_HUMAN
A:
[28-696]
--------------------------------------------------
D
F
F
K
Y
A
C
G
G
W
L
K
-
R
N
V
I
P
E
T
S
S
R
Y
G
N
F
D
I
L
R
D
E
L
E
V
V
---
L
-----
K
D
V
L
Q
E
P
K
T
E
----
D
I
V
A
V
------
Q
K
-----
A
K
A
L
Y
----
R
S
-
C
I
--
N
E
S
A
I
D
S
R
G
G
E
P
L
L
K
------------
L
L
P
D
I
Y
G
W
P
V
A
T
---------
E
NWEQKY
G
--
A
S
-------
W
-----------
T
A
E
-------------
K
A
I
A
Q
L
N
SKY
G
-
K
K
V
L
I
N
L
--------
F
V
G
T
----
D
D
K
N
----
S
V
N
H
V
I
H
I
D
Q
P
R
---------
L
G
----
L
P
S
R
D
Y
Y
E
C
T
G
I
Y
K
E
A
C
T
A
Y
V
D
F
M
I
S
V
A
R
L
I
R
Q
E
E
R
--
L
P
I
-------------
D
------
E
-
N
Q
L
A
L
E
M
N
K
V
M
E
L
E
K
E
I
A
N
A
---
T
A
K
P
---
E
D
R
N
D
P
M
L
L
Y
N
K
M
T
L
A
Q
I
Q
N
N
F
S
L
E
I
NGK
P
------
F
S
W
L
N
F
T
N
---------------
E
---
I
--
M
S
T
V
N
I
S
I
-----
T
--
N
E
------
E
D
V
---
V
V
------
Y
A
P
E
Y
L
T
K
L
K
P
I
----
L
T
K
Y
S
A
R
--------
D
L
Q
N
L
M
S
W
R
F
I
-
M
D
L
-
V
S
S
L
S
R
T
Y
--------
K
E
S
R
N
---
A
F
R
K
A
L
-
Y
G
T
T
S
E
T
A
T
W
R
R
C
A
N
Y
V
N
--
G
N
------
M
E
N
A
V
G
R
L
-
Y
V
E
A
A
F
------------------
A
G
-------
E
S
K
H
V
-------
V
E
D
L
I
A
Q
I
R
E
V
F
I
Q
T
L
D
----------------------
D
L
T
W
M
D
A
E
T
K
K
R
A
E
E
-----------
K
A
L
A
I
K
E
-----
R
I
----
G
Y
P
------
D
D
I
-------
V
S
N
-
D
--
N
K
L
N
N
------
E
Y
L
---------------
E
L
N
Y
K
EDE
Y
F
E
N
I
I
Q
N
L
K
F
S
Q
S
K
-
Q
L
K
------
K
L
R
E
K
V
D
K
D
E
W
I
S
G
----
A
A
V
V
N
A
F
Y
S
-
S
G
R
N
Q
I
--
V
F
P
A
G
I
L
Q
P
P
F
------
F
S
A
Q
Q
S
N
S
L
N
Y
-
G
G
I
G
M
V
I
G
H
E
I
T
H
G
F
D
D
N
G
-------
R
N
F
N
K
D
G
D
L
V
D
W
--
W
T
Q
Q
S
A
--
S
N
F
K
E
Q
S
----
Q
C
M
V
Y
-
Q
Y
------
G
N
F
---
S
WDL
A
G
---
G
-
Q
H
-----
L
N
G
I
N
T
L
G
E
N
I
A
D
N
G
G
L
G
Q
A
Y
R
A
Y
Q
N
Y
I
K
K
NGE
E
---
K
-------------
L
----------
L
-------------
P
-
G
-
L
---------------------
D
LN
H
K
Q
L
-------
F
F
L
----------
N
F
A
Q
V
W
C
G
T
Y
R
P
----
E
Y
A
V
N
S
I
K
------------
T
D
V
H
S
P
G
N
F
R
I
I
G
T
L
Q
N
S
A
E
F
S
E
A
F
H
C
R
--
K
N
S
Y
M
N
P
E
K
K
C
R
V
W
-----------------------------------
8
PsiBlast_PDB
87.04
27%
-56
- C6 -
1Y8J
6
NEP_HUMAN
A:
[28-696]
--------------------------------------------------
D
F
F
K
Y
A
C
G
G
W
L
K
-
R
N
V
I
P
E
T
S
S
R
Y
G
N
F
D
I
L
R
D
E
L
E
V
V
---
L
-----
K
D
V
L
Q
E
P
K
T
E
----
D
I
V
A
V
------
Q
K
-----
A
K
A
L
Y
----
R
S
-
C
I
--
N
E
S
A
I
D
S
R
G
G
E
P
L
L
K
------------
L
L
P
D
I
Y
G
W
P
V
A
T
---------
E
NWEQKY
G
--
A
S
-------
W
-----------
T
A
E
-------------
K
A
I
A
Q
L
N
SKY
G
-
K
K
V
L
I
N
L
--------
F
V
G
T
----
D
D
K
N
----
S
V
N
H
V
I
H
I
D
Q
P
R
---------
L
G
----
L
P
S
R
D
Y
Y
E
C
T
G
I
Y
K
E
A
C
T
A
Y
V
D
F
M
I
S
V
A
R
L
I
R
Q
E
E
R
--
L
P
I
-------------
D
------
E
-
N
Q
L
A
L
E
M
N
K
V
M
E
L
E
K
E
I
A
N
A
---
T
A
K
P
---
E
D
R
N
D
P
M
L
L
Y
N
K
M
T
L
A
Q
I
Q
N
N
F
S
L
E
I
NGK
P
------
F
S
W
L
N
F
T
N
---------------
E
---
I
--
M
S
T
V
N
I
S
I
-----
T
--
N
E
------
E
D
V
---
V
V
------
Y
A
P
E
Y
L
T
K
L
K
P
I
----
L
T
K
Y
S
A
R
--------
D
L
Q
N
L
M
S
W
R
F
I
-
M
D
L
-
V
S
S
L
S
R
T
Y
--------
K
E
S
R
N
---
A
F
R
K
A
L
-
Y
G
T
T
S
E
T
A
T
W
R
R
C
A
N
Y
V
N
--
G
N
------
M
E
N
A
V
G
R
L
-
Y
V
E
A
A
F
------------------
A
G
-------
E
S
K
H
V
-------
V
E
D
L
I
A
Q
I
R
E
V
F
I
Q
T
L
D
----------------------
D
L
T
W
M
D
A
E
T
K
K
R
A
E
E
-----------
K
A
L
A
I
K
E
-----
R
I
----
G
Y
P
------
D
D
I
-------
V
S
N
-
D
--
N
K
L
N
N
------
E
Y
L
---------------
E
L
N
Y
K
EDE
Y
F
E
N
I
I
Q
N
L
K
F
S
Q
S
K
-
Q
L
K
------
K
L
R
E
K
V
D
K
D
E
W
I
S
G
----
A
A
V
V
N
A
F
Y
S
-
S
G
R
N
Q
I
--
V
F
P
A
G
I
L
Q
P
P
F
------
F
S
A
Q
Q
S
N
S
L
N
Y
-
G
G
I
G
M
V
I
G
H
E
I
T
H
G
F
D
D
N
G
-------
R
N
F
N
K
D
G
D
L
V
D
W
--
W
T
Q
Q
S
A
--
S
N
F
K
E
Q
S
----
Q
C
M
V
Y
-
Q
Y
------
G
N
F
---
S
WDL
A
G
---
G
-
Q
H
-----
L
N
G
I
N
T
L
G
E
N
I
A
D
N
G
G
L
G
Q
A
Y
R
A
Y
Q
N
Y
I
K
K
NGE
E
---
K
-------------
L
----------
L
-------------
P
-
G
-
L
---------------------
D
LN
H
K
Q
L
-------
F
F
L
----------
N
F
A
Q
V
W
C
G
T
Y
R
P
----
E
Y
A
V
N
S
I
K
------------
T
D
V
H
S
P
G
N
F
R
I
I
G
T
L
Q
N
S
A
E
F
S
E
A
F
H
C
R
--
K
N
S
Y
M
N
P
E
K
K
C
R
V
W
-----------------------------------
11
PsiBlast_PDB
86.75
27%
-59
- C6 -
4CTH
13
NEP_HUMAN
A:
[41-709]
--------------------------------------------------
D
F
F
K
Y
A
C
G
G
W
L
K
-
R
N
V
I
P
E
T
S
S
R
Y
G
N
F
D
I
L
R
D
E
L
E
V
V
---
L
-----
K
D
V
L
Q
E
P
K
T
E
----
D
I
V
A
V
------
Q
K
-----
A
K
A
L
Y
----
R
S
-
C
I
--
N
E
S
A
I
D
S
R
G
G
E
P
L
L
K
------------
L
L
P
D
I
Y
G
W
P
V
A
T
---------
E
NWEQKY
G
--
A
S
-------
W
-----------
T
A
E
-------------
K
A
I
A
Q
L
N
SKY
G
-
K
K
V
L
I
N
L
--------
F
V
G
T
----
D
D
K
N
----
S
V
N
H
V
I
H
I
D
Q
P
R
---------
L
G
----
L
P
S
R
D
Y
Y
E
C
T
G
I
Y
K
E
A
C
T
A
Y
V
D
F
M
I
S
V
A
R
L
I
R
Q
E
E
R
--
L
P
I
-------------
D
------
E
-
N
Q
L
A
L
E
M
N
K
V
M
E
L
E
K
E
I
A
N
A
---
T
A
K
P
---
E
D
R
N
D
P
M
L
L
Y
N
K
M
T
L
A
Q
I
Q
N
N
F
S
L
E
I
NG
K
P
------
F
S
W
L
N
F
T
N
------
E
I
--------------
M
S
T
V
N
I
S
I
-----
T
--
N
E
------
E
D
V
---
V
V
------
Y
A
P
E
Y
L
T
K
L
K
P
I
----
L
T
K
Y
S
A
R
--------
D
L
Q
N
L
M
S
W
R
F
I
-
M
D
L
-
V
S
S
L
S
R
T
Y
--------
K
E
S
R
N
---
A
F
R
K
A
L
Y
V
T
T
S
E
T
A
T
W
R
R
C
A
N
Y
V
-
N
--
G
N
------
M
E
N
A
V
G
R
L
-
Y
V
E
A
A
F
------------------
A
G
-------
E
S
K
H
V
-------
V
E
D
L
I
A
Q
I
R
E
V
F
I
Q
T
L
D
----------------------
D
L
T
W
M
D
A
E
T
K
K
R
A
E
E
-----------
K
A
L
A
I
K
E
-----
R
I
----
G
Y
P
------
D
D
I
-------
V
S
N
-
D
--
N
K
L
N
N
------
E
Y
L
---------------
E
L
N
Y
K
EDE
Y
F
E
N
I
I
Q
N
L
K
F
S
Q
S
K
-
Q
L
K
------
K
L
R
E
K
V
D
K
D
E
W
I
S
G
----
A
A
V
V
N
A
F
Y
S
-
S
G
R
N
Q
I
--
V
F
P
A
G
I
L
Q
P
P
F
------
F
S
A
Q
Q
S
N
S
L
N
Y
-
G
G
I
G
M
V
I
G
H
E
I
T
H
G
F
D
D
N
G
-------
R
N
F
N
K
D
G
D
L
V
D
W
--
W
T
Q
Q
S
A
--
S
N
F
K
E
Q
S
----
Q
C
M
V
Y
-
Q
Y
------
G
N
F
---
S
WDL
A
G
---
G
-
Q
H
-----
L
N
G
I
N
T
L
G
E
N
I
A
D
N
G
G
L
G
Q
A
Y
R
A
Y
Q
N
Y
I
K
K
NGE
E
---
K
-------------
L
----------
L
-------------
P
-
G
-
L
---------------------
D
LN
H
K
Q
L
-------
F
F
L
----------
N
F
A
Q
V
W
C
G
T
Y
R
P
----
E
Y
A
V
N
S
I
K
------------
T
D
V
H
S
P
K
N
F
R
I
I
G
T
L
Q
N
S
A
E
F
S
E
A
F
H
C
R
--
K
N
S
Y
M
N
P
E
K
K
C
R
V
W
-----------------------------------
6
PsiBlast_PDB
86.64
27%
-54
- C6 -
1R1I
5
NEP_HUMAN
A:
[28-696]
--------------------------------------------------
D
F
F
K
Y
A
C
G
G
W
L
K
-
R
N
V
I
P
E
T
S
S
R
Y
G
N
F
D
I
L
R
D
E
L
E
V
V
---
L
-----
K
D
V
L
Q
E
P
K
T
E
----
D
I
V
A
V
------
Q
K
-----
A
K
A
L
Y
----
R
S
-
C
I
--
N
E
S
A
I
D
S
R
G
G
E
P
L
L
K
------------
L
L
P
D
I
Y
G
W
P
V
A
T
---------
E
NWEQKY
G
--
A
S
-------
W
-----------
T
A
E
-------------
K
A
I
A
Q
L
N
S
KY
G
-
K
K
V
L
I
N
L
--------
F
V
G
T
----
D
D
K
N
----
S
V
N
H
V
I
H
I
D
Q
P
R
---------
L
G
----
L
P
S
R
D
Y
Y
E
C
T
G
I
Y
K
E
A
C
T
A
Y
V
D
F
M
I
S
V
A
R
L
I
R
Q
E
E
R
--
L
P
I
-------------
D
------
E
-
N
Q
L
A
L
E
M
N
K
V
M
E
L
E
K
E
I
A
N
A
---
T
A
K
P
---
E
D
R
N
D
P
M
L
L
Y
N
K
M
T
LAQIQNN
F
S
L
E
I
NGK
P
------
F
S
W
L
N
F
T
N
---------------
E
---
I
--
M
S
T
V
N
I
S
I
-----
T
--
N
E
------
E
D
V
---
V
V
------
Y
A
P
E
Y
L
T
K
L
K
P
I
----
L
T
K
Y
S
A
R
--------
D
L
Q
N
L
M
S
W
R
F
I
-
M
D
L
-
V
S
S
L
S
R
T
Y
--------
K
E
S
R
N
---
A
F
R
K
A
L
-
Y
G
T
T
S
E
T
A
T
W
R
R
C
A
N
Y
V
N
--
G
N
------
M
E
N
A
V
G
R
L
-
Y
V
E
A
A
F
------------------
A
G
-------
E
S
K
H
V
-------
V
E
D
L
I
A
Q
I
R
E
V
F
I
Q
T
L
D
----------------------
D
L
T
W
M
D
A
E
T
K
K
R
A
E
E
-----------
K
A
L
A
I
K
E
-----
R
I
----
G
Y
P
------
D
D
I
-------
V
S
N
-
D
--
N
K
L
N
N
------
E
Y
L
---------------
E
L
N
Y
K
EDE
Y
F
E
N
I
I
Q
N
L
K
F
S
Q
S
K
-
Q
L
K
------
K
L
R
E
K
V
D
K
D
E
W
I
S
G
----
A
A
V
V
N
A
F
Y
S
-
S
G
R
N
Q
I
--
V
F
P
A
G
I
L
Q
P
P
F
------
F
S
A
Q
Q
S
N
S
L
N
Y
-
G
G
I
G
M
V
I
G
H
E
I
T
H
G
F
D
D
N
G
-------
R
N
F
N
K
D
G
D
L
V
D
W
--
W
T
Q
Q
S
A
--
S
N
F
K
E
Q
S
----
Q
C
M
V
Y
-
Q
Y
------
G
N
F
---
S
WDL
A
G
---
G
-
Q
H
-----
L
N
G
I
N
T
L
G
E
N
I
A
D
N
G
G
L
G
Q
A
Y
R
A
Y
Q
N
Y
I
K
KN
G
E
E
---
K
-------------
L
----------
L
-------------
P
-
G
-
L
---------------------
D
LN
H
K
Q
L
-------
F
F
L
----------
N
F
A
Q
V
W
C
G
T
Y
R
P
----
E
Y
A
V
N
S
I
K
------------
T
D
V
H
S
P
G
N
F
R
I
I
G
T
L
Q
N
S
A
E
F
S
E
A
F
H
C
R
--
K
N
S
Y
M
N
P
E
K
K
C
R
V
W
-----------------------------------
9
PsiBlast_PDB
85.94
27%
-56
- C6 -
2QPJ
5
NEP_HUMAN
A:
[28-696]
--------------------------------------------------
D
F
F
K
Y
A
C
G
G
W
L
K
-
R
N
V
I
P
E
T
S
S
R
Y
G
N
F
D
I
L
R
D
E
L
E
V
V
---
L
-----
K
D
V
L
Q
E
P
K
T
E
----
D
I
V
A
V
------
Q
K
-----
A
K
A
L
Y
----
R
S
-
C
I
--
N
E
S
A
I
D
S
R
G
G
E
P
L
L
K
------------
L
L
P
D
I
Y
G
W
P
V
A
T
---------
E
N
W
E
Q
K
Y
G
--
A
S
-------
W
-----------
T
A
E
-------------
K
A
I
A
Q
L
N
SKY
G
-
K
K
V
L
I
N
L
--------
F
V
G
T
----
D
D
K
N
----
S
V
N
H
V
I
H
I
D
Q
P
R
---------
L
G
----
L
P
S
R
D
Y
Y
E
C
T
G
I
Y
K
E
A
C
T
A
Y
V
D
F
M
I
S
V
A
R
L
I
R
Q
E
E
R
--
L
P
I
-------------
D
------
E
-
N
Q
L
A
L
E
M
N
K
V
M
E
L
E
K
E
I
A
N
A
---
T
A
K
P
---
E
D
R
N
D
P
M
L
L
Y
N
K
M
T
L
A
Q
I
Q
N
N
F
S
L
E
I
NGK
P
------
F
S
W
L
N
F
T
N
---------------
E
---
I
--
M
S
T
V
N
I
S
I
-----
T
--
N
E
------
E
D
V
---
V
V
------
Y
A
P
E
Y
L
T
K
L
K
P
I
----
L
T
K
Y
S
A
R
--------
D
L
Q
N
L
M
S
W
R
F
I
-
M
D
L
-
V
S
S
L
S
R
T
Y
--------
K
E
S
R
N
---
A
F
R
K
A
L
-
Y
G
T
T
S
E
T
A
T
W
R
R
C
A
N
Y
V
N
--
G
N
------
M
E
N
A
V
G
R
L
-
Y
V
E
A
A
F
------------------
A
G
-------
E
S
K
H
V
-------
V
E
D
L
I
A
Q
I
R
E
V
F
I
Q
T
L
D
----------------------
D
L
T
W
M
D
A
E
T
K
K
R
A
E
E
-----------
K
A
L
A
I
K
E
-----
R
I
----
G
Y
P
------
D
D
I
-------
V
S
N
-
D
--
N
K
L
N
N
------
E
Y
L
---------------
E
L
N
Y
K
EDE
Y
F
E
N
I
I
Q
N
L
K
F
S
Q
S
K
-
Q
L
K
------
K
L
R
E
K
V
D
K
D
E
W
I
S
G
----
A
A
V
V
N
A
F
Y
S
-
S
G
R
N
Q
I
--
V
F
P
A
G
I
L
Q
P
P
F
------
F
S
A
Q
Q
S
N
S
L
N
Y
-
G
G
I
G
M
V
I
G
H
E
I
T
H
G
F
D
D
N
G
-------
R
N
F
N
K
D
G
D
L
V
D
W
--
W
T
Q
Q
S
A
--
S
N
F
K
E
Q
S
----
Q
C
M
V
Y
-
Q
Y
------
G
N
F
---
S
WDL
A
G
---
G
-
Q
H
-----
L
N
G
I
N
T
L
G
E
N
I
A
D
N
G
G
L
G
Q
A
Y
R
A
Y
Q
N
Y
I
K
K
NGE
E
---
K
-------------
L
----------
L
-------------
P
-
G
-
L
---------------------
D
LN
H
K
Q
L
-------
F
F
L
----------
N
F
A
Q
V
W
C
G
T
Y
R
P
----
E
Y
A
V
N
S
I
K
------------
T
D
V
H
S
P
G
N
F
R
I
I
G
T
L
Q
N
S
A
E
F
S
E
A
F
H
C
R
--
K
N
S
Y
M
N
P
E
K
K
C
R
V
W
-----------------------------------
36
Fugue
55.19
19%
-42
- C4 -
4F1N
1
?
A:
[12-1046]
D
T
H
A
I
YKVENRH
D
Y
G
T
K
G
T
K
V
D
I
L
T
NHILLAVGNDVP
T
E
K
I
D
K
-------
E
L
V
P
K
L
D
G
W
W
-
K
-
T
A
F
I
F
T
Y
H
I
D
F
K
L
S
K
P
K
K
Y
E
L
I
E
A
---
L
L
D
E
D
E
I
L
Y
K
Y
R
D
R
I
A
FNGE
D
T
I
-
Y
------
S
H
VPLEE
F
T
L
F
D
GCWE
E
M
-
V
S
Q
I
T
L
K
F
S
G
K
V
G
L
K
D
I
Y
N
DTTTQD
T
E
V
Q
E
S
R
M
S
A
I
D
K
T
C
L
L
S
---------
L
------
L
--
G
A
-------
K
-----------
F
M
S
TD
D
L
I
F
Q
V
QGN
K
F
F
I
F
N
------
N
-
F
A
K
A
I
P
F
QIG
G
Y
L
L
Q
G
F
T
V
----
S
L
T
H
V
YG
G
V
A
L
N
T
V
S
V
P
A
P
F
---------
I
K
HTKY
L
P
G
D
P
R
F
K
N
N
E
K
E
Q
F
T
L
M
D
W
--------
I
I
E
C
Y
H
Q
S
--
K
A
I
R
D
I
RYNPKTAPPP
S
------
V
-
K
D
L
N
Y
F
V
E
K
N
T
D
I
S
A
L
L
K
G
L
---
K
V
Y
R
PYI
N
R
S
S
K
G
I
V
G
F
T
------------------
R
ESAVSM
R
N
T
I
D
Y
F
K
------
R
K
------
Y
D
---
I
T
-
L
K
Y
P
D
M
K
L
-----
V
N
L
G
G
------
K
N
D
---
V
V
PPEC
L
T
I
V
P
G
-----
Q
K
L
KGQI
F
D
T
K
-
T
Y
--------
I
D
F
S
A
I
R
P
T
E
K
F
D
L
I
-
S
R
L
S
M
P
A
I
K
R
G
L
T
D
S
E
N
S
A
Y
Q
F
M
R
V
P
S
R
I
L
-
D
A
P
V
V
Q
F
K
E
S
T
F
E
Y
K
D
K
S
YG
T
K
------
H
E
E
S
K
G
N
W
N
M
K
G
H
Q
F
ISTPAKQ
V
N
L
R
A
I
F
INNA
N
T
-------
A
P
P
A
S
-------
M
E
S
E
L
D
I
S
M
D
K
F
A
S
D
V
K
Q
L
GVDFNVS
G
K
P
I
L
I
N
QFGPPI
K
P
T
F
E
T
S
P
G
E
I
S
L
L
N
-----------
L
L
E
N
I
P
S
N
T
Y
I
L
Y
V
----
L
R
R
------
G
N
D
-------
S
A
V
Y
D
R
L
K
Y
I
T
D
------
L
K
F
G
A
L
N
S
C
V
V
W
D
N
F
K
K
N
S
I
-------
Q
Y
N
S
N
V
V
M
K
M
N
L
K
L
-
L
G
S
N
H
SLSI
E
N
N
K
L
L
I
D
K
E
S
N
L
P
IL
V
L
G
S
D
V
T
H
Y
P
E
-
K
D
Q
N
S
I
--
A
S
L
V
G
S
Y
D
D
K
F
T
Q
F
P
G
D
Y
M
L
Q
D
G
P
G
E
E
I
I
T
N
V
G
S
L
M
L
N
R
L
K
I
Y
Q
K
H
N
N
GKLPT
K
I
M
Y
F
R
D
G
V
S
V
D
Q
F
S
Q
V
V
K
I
E
V
--
K
S
I
K
E
S
V
----
R
K
F
G
P
-
Q
L
------
N
G
G
---
N
---
K
Y
---
D
-
P
P
-----
V
T
C
I
A
T
V
K
R
N
Q
V
R
F
I
P
I
Q
E
N
A
K
N
E
K
G
-------
E
-----------------
E
----------
V
-------------
A
-
V
-
Q
SMGNVMPGTVVDRGITSVAHF
D
-------------
F
F
I
QSHQALK
G
T
G
V
P
C
H
Y
W
C
L
Y
D
E
N
QST
S
D
Y
L
Q
E
I
C
N
N
L
C
Y
I
FGRSTTS
V
K
V
P
A
P
V
Y
Y
A
D
L
L
C
T
R
A
T
C
F
F
K
A
G
F
E
L
N
M
A
Q
A
---
T
V
S
K
N
V
L
L
P
QVNDNIKSVMYYI----------------------
31
Fugue
51.53
14%
-31
- C3 -
4XVK
4
DPOLN_HUMAN
A:
[1-666]
--------------------------------------
K
K
H
F
C
-------
D
I
R
H
--
L
D
D
W
A
K
-
S
Q
L
I
E
M
L
K
Q
-------
A
A
A
L
V
I
T
V
---
M
Y
T
D
G
S
T
Q
L
G
A
D
Q
T
P
V
----
S
S
V
-
R
------
G
I
-----
V
V
L
V
K
----
R
Q
-
A
C
--
G
P
V
L
E
G
F
V
S
D
D
P
C
I
Y
------------
I
Q
I
E
H
S
A
I
W
D
-----------------------------------------------------------
Q
E
Q
------
E
-
A
H
Q
Q
F
A
R
--------
N
V
L
F
----
Q
T
M
K
----
C
K
C
P
V
I
C
F
N
A
K
D
---------
F
V
----
R
I
V
L
Q
F
F
G
N
D
G
-------------------------------------------
S
------
W
-
K
H
V
A
D
F
I
----
G
L
D
P
R
I
A
A
W
---
L
I
D
P
---
S
D
A
T
P
S
F
E
D
L
V
------------------
E
------
K
Y
C
E
K
S
I
T
------
V
K
------
V
N
---
S
T
-
Y
G
N
S
S
R
N
I
-----
V
--
N
Q
------
N
V
R
---
E
N
------
L
K
T
L
-----
Y
R
L
----
T
M
D
L
-
C
S
--------
K
L
K
D
Y
G
L
W
Q
L
F
R
T
-
L
-
E
L
P
L
I
P
I
L
A
V
M
E
S
H
A
I
Q
V
N
K
E
---
E
M
E
K
T
S
-
A
L
L
G
A
R
L
K
E
L
E
Q
E
A
H
F
V
A
--
G
E
RFLITS
N
N
Q
L
R
E
I
L
-
F
G
K
L
K
L
------------------
H
L
LSYPSTS
E
A
V
L
N
A
L
R
DLHP
L
P
K
I
I
L
E
Y
R
Q
V
H
K
I
K
S
T
----------------------
F
V
D
G
L
L
A
C
M
K
K
G
S
I
S
S
T
W
N
QTGTVTG
R
L
S
A
K
H
P
-----
N
I
QGIS
K
H
P
------
I
Q
I
-------
T
T
P
K
K
--
I
L
T
I
S
------
P
R
A
---------------
M
F
-------
V
---
S
S
K
G
H
T
F
L
A
A
-
D
F
S
------
Q
-------
I
E
L
R
I
L
----
T
H
L
S
G
---
D
-
P
E
L
L
K
L
DD
V
F
S
T
L
T
S
Q
W
K
D
------
V
P
V
E
Q
V
T
H
A
D
R
-
E
Q
T
K
K
V
V
Y
A
V
V
Y
G
A
G
K
E
R
L
-------
A
A
C
------------
L
G
V
P
I
--
Q
E
A
A
Q
F
L
----
E
S
F
L
Q
-
K
Y
------
K
K
I
---
K
---
D
F
---
A
-
R
A
-----
A
I
A
Q
C
H
Q
T
G
C
V
V
S
I
M
G
R
R
R
P
L
P
R
I
H
--------
A
---
H
-------------
D
----------
Q
-------------
Q
-
L
-
R
---------------------
A
-------------
Q
A
E
----------
R
Q
A
V
N
F
V
V
Q
G
S
A
----
A
D
L
C
K
L
A
M
------------
I
H
V
F
T
A
V
A
A
S
H
T
L
T
A
R
L
V
A
Q
I
H
D
E
L
L
F
E
V
E
D
P
Q
I
P
E
C
A
A
L
V
R
R
T
M
E
S
LEQVQALELQLQ
V
P
L
K
V
S
L
S
A
GRSWGHLVPLQ
34
Fugue
50.36
15%
-36
- C2 -
4XGC
-
?
C:
[1-676]
-----------------------------------------
M
Q
-------
P
F
Y
E
E
Y
R
K
A
W
N
Q
I
N
D
H
I
A
D
L
Q
H
R
S
-----
Y
A
R
T
L
E
Q
L
---
V
D
F
V
V
G
Q
A
E
R
D
E
V
L
P
T
----
A
A
L
-
L
TGINQP
D
H
-----
L
S
Q
F
T
----
A
L
-
T
Q
--
R
L
H
A
Q
R
-----
A
A
M
V
------------
C
V
L
Q
S
R
D
C
A
T
L
K
---------
A
------
A
--
V
E
-------
T
-----------
L
V
--------------
F
G
L
V
------
E
-
D
N
A
E
V
E
Q
--------
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R
R
S
----
Q
C
T
M
----
K
Q
L
K
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W
Y
T
N
N
F
D
SEQ
K
R
R
Q
L
V
V
I
----
L
P
D
F
E
C
F
--
N
A
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V
L
Q
D
L
I
L
I
--------
L
S
A
H
C
G
S
L
P
F
V
L
V
L
G
V
----------
A
------
T
-
A
--------
M
T
A
V
H
G
T
L
P
Y
H
---
V
S
S
K
---------------------------------------
I
R
L
R
V
F
Q
T
------
Q
A
------
A
P
---
T
G
-
L
N
E
V
L
D
K
V
-----
L
------------------------
L
S
P
K
-----
Y
A
F
------
H
L
-
S
G
--------
K
T
F
K
F
L
T
H
I
F
L
Y
Y
D
F
S
I
H
G
F
I
Q
G
F
K
Y
C
L
M
E
H
F
F
--
G
G
---
N
A
F
A
L
C
-
T
D
Y
S
K
A
L
G
R
I
K
Q
L
T
H
E
D
M
--
E
T
------
I
R
R
L
P
S
F
R
-
P
Y
V
E
Q
I
------------------
N
D
----------
C
K
-------
R
I
I
A
V
L
T
D
D
D
Y
L
K
K
K
L
P
----------------------
Q
L
L
R
D
C
L
L
H
F
L
L
F
R
C
-----------
S
L
E
F
L
T
E
-----
L
V
----
G
D
L
------
P
R
C
-------
P
--------------------------------------------------
L
G
K
L
R
R
E
L
-
Y
V
N
------
C
L
N
R
A
I
I
S
T
P
E
Y
K
E
----
C
L
Q
M
L
S
F
L
S
-
K
D
E
F
V
A
--
K
V
N
R
A
L
E
R
T
E
Q
------
F
L
V
E
E
I
A
P
L
E
----
L
G
E
A
C
T
A
V
L
R
P
K
L
E
A
I
R
-------
L
A
V
D
E
V
G
---------
R
A
L
Q
--
K
T
L
Q
L
I
E
----
T
Q
I
V
Q
D
H
L
------
R
A
L
---
Q
---
D
A
---
P
-
P
I
HELFV
F
S
D
I
A
T
V
R
R
N
I
I
--
G
A
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R
A
A
L
H
T
A
L
N
-------
N
---
P
-------------
H
----------
F
P------------
D
-
L
-
S
---------------------
V
-------------
V
Y
K
----------
L
H
L
E
C
G
R
M
I
N
L
F
----
D
W
L
Q
A
F
R
S
------------
V
V
P
Q
I
Q
A
R
F
T
R
A
V
A
E
L
Q
F
L
G
Y
I
K
M
S
K
R
K
T
-
D
H
A
T
R
L
T
------
W
-----------------------------------
33
Fugue
49.07
11%
-17
* C4 *
2UXW
4
ACADV_HUMAN
A:
[21-607]
---------------------------------------
Q
S
M
S
-------
F
A
V
G
M
F
K
G
Q
L
T
T
-
D
Q
V
F
P
Y
P
S
V
----
L
N
E
E
Q
T
Q
F
L
K
E
---
L
V
E
P
V
S
R
F
F
E
E
V
N
D
P
A
----
K
N
D
-
A
------
L
E
-----
M
V
E
-
E
----
T
T
-
W
Q
--
G
L
K
E
L
G
A
F
G
L
----
Q
------------
V
P
S
E
L
G
G
V
G
L
C
N
---------
T
------
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--
Y
A
-------
R
-----------
L
V
E
-------------
I
V
G
M
------
H
---------------------------
D
----
L
G
V
G
I
T
L
G
A
H
Q
S
---------
I
G
----
F
K
G
I
L
L
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
--------
A
---
S
G
E
T
--
V
A
A
F
C
L
----------
T
------
E
-
P
S
--------
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G
S
D
A
A
S
I
R
T
---
S
A
V
P
---
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P
C
G
K
Y
Y
T
L
N
G
------------------
S
------
K
L
W
I
S
N
G
G
------
L
A
------
D
I
---
F
T
-
V
F
A
K
T
P
V
T
-----
D
--
P
A
------
T
G
A
-------------
V
K
-----
E
K
I
----
T
A
F
V
-
V
E
--------
R
G
F
G
G
I
T
H
G
P
P
E
K
K
M
-
G
I
K
A
S
N
T
A
E
V
F
F
D
G
-----
V
R
---
V
P
S
E
N
V
-
L
G
E
V
G
S
-
G
F
K
V
A
M
H
I
L
N
N
--
G
R
------
F
G
M
A
A
A
L
A
-
G
T
M
R
G
I
------------------
I
A
-------
K
A
V
D
H
-------
A
T
N
R
--
T
Q
F
G
E
K
I
H
N
F
G
----------------------
L
I
Q
E
K
L
A
R
M
V
M
L
Q
Y
V
-----------
T
E
S
M
A
Y
M
-----
V
S
----
A
N
M
------
D
Q
G
-------
A
T
D
F
Q
--
I
E
A
A
I
------
S
K
I
---------------
F
G
-------
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
------
G
F
M
K
E
P
G
V
E
R
V
L
R
D
----
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
--
F
V
A
L
Q
G
C
M
D
K
G
------
K
E
L
S
G
L
G
S
A
L
K
-
N
P
F
G
-------------
S
G
-------
L
S
L
S
G
L
V
H
P
E
L
S
--
R
S
G
E
L
A
--
V
R
A
L
E
Q
F
----
A
T
V
V
E
-
A
K
--------
L
---
I
---
K
H
---
K
-
K
G
-----
I
V
N
E
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
V
L
S
-------
R
---
A
-------------
S
----------
R
-------------
S
-
L
-
S
E
GHPT
A
---------------
Q
-------------
H
E
K
----------
M
L
C
D
T
W
C
I
E
A
A
A
----
R
I
R
E
G
M
A
A
------------
L
Q
S
D
P
W
----
Q
Q
E
L
Y
R
N
F
K
S
I
S
K
A
L
V
E
R
G
G
V
V
T
S
N
P
L
G
F
----------------------------------------
35
Fugue
48.61
14%
-26
- C5 -
4U1C
-
EIF3C_YEAST
C:
[6-549]
-----------------------------------------
Q
E
-------
D
F
F
T
R
L
Q
T
I
I
D
S
-
R
G
------
K
K
T
V
N
Q
Q
S
L
I
S
T
L
E
E
L
---
L
T
V
------------
A
----
E
K
P
-
Y
------
E
F
-----
I
M
A
Y
L
----
T
L
I
P
S
--
R
F
D
A
S
A
N
L
S
Y
Q
P
I
D
Q
------------
W
K
S
S
F
N
D
I
S
K
L
L
---------
S
------
I
--
L
D
-------
Q
-----------
T
I
D
-------------
T
Y
Q
V
------
N
------
E
F
--------
A
D
P
I
----
D
F
I
E
----
D
E
P
K
-------------------------------
E
D
S
D
G
V
K
R
I
L
G
--------------------
S
I
F
S
F
----------
V
------
E
-
R
L
D
D
E
F
M
K
S
L
L
N
I
D
P
H
S
S
D
Y
---
L
I
R
L
---
R
D
E
Q
S
I
Y
N
L
I
L
------------------
R
------
T
Q
L
Y
F
E
A
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------
L
K
------
D
E
---
H
D
-
L
E
R
A
L
T
R
P
-----
F
--
V
K
------
R
L
D
---
H
I
------
Y
----------
Y
----
K
S
E
N
-
L
I
--------
K
I
M
E
T
A
A
W
N
I
I
P
A
Q
F
-
K
S
K
F
T
S
K
D
Q
L
D
S
A
D
Y
V
D
N
L
I
D
---
G
L
S
T
I
L
-
S
K
Q
N
N
I
A
V
Q
K
R
A
I
L
Y
N
I
-----------
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A
L
N
------
K
D
F
------------------
Q
T
-------
A
K
D
M
L
-------
L
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S
Q
V
-------
Q
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N
I
N
----------------------
Q
F
D
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S
L
Q
I
L
F
N
R
V
V
V
-----------
Q
L
G
L
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A
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-----
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----
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L
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------
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E
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-------
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Q
I
L
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--
D
L
L
S
S
------
S
H
L
---------------
R
E
-------
I
L
G
Q
Q
S
L
H
R
I
S
L
N
S
---
S
------
N
N
A
S
A
D
E
R
A
R
Q
C
L
P
----
Y
H
Q
---
H
I
N
-
L
D
L
I
D
V
--
V
F
L
T
C
S
L
L
I
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I
------
P
R
M
----
T
A
F
Y
-
S
G
I
K
V
K
R
I
P
Y
S
P
K
S
I
R
R
S
L
-------
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H
Y
D
K
L
S
F
Q
G
P
P
--
E
T
L
R
D
Y
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F
A
A
K
S
M
Q
KGNW
R
D
S
V
K
-
Y
L
------
R
E
I
---
K
---
S
W
---
A
-
L
L
-----
P
N
M
E
T
V
L
N
S
L
T
E
R
V
Q
V
E
S
L
K
T
Y
F
F
S
F
-------
K
RFY
S
-------------
S
----------
F
-------------
S
-
V
-
A
---------------------
K
-------------
L
A
E
----------
L
F
-
D
L
P
E
N
K
V
V
E
----
V
L
Q
S
V
I
A
E
------------
L
E
I
P
A
-----------
K
L
N
D
E
K
T
I
F
V
V
E
K
G
D
E
I
T
K
L
E
E
A
M
V
K
L
------------------------------------