@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1907: (2015-12-11 )
MADVKVVNNEDSRGQKQDLKAKLFHIKIGSVPLPVYVCLALLILLAGFLQKLPVNMLGGFAVILTMGWFLGTIGASIPGFKNFGGPAILSLLVPSILVFFNLINKNVLESTNMLMKQANFLYFYIACLVSGSILGMNRKMLIQGLLRMIFPMLLGMVCAMMVGTFVGVILGLEWRHTLFYIVTPVLAGGIGEGILPLSLGYSSITGVASEQLVAQLIPATIIGNFFAILCTALLNRLGEKKPHLSGQGQLVRLNKGEDMSDIIADHSGPIDVKKMGGGVLTACSLFIFGHLLQQLTGFPGPVLMIVAAAILKYINVIPRETQNGAKQLYKFISGNFTFPLMAGLGLLYIPLKDVVATLSIQYFIVVISVVFTVISVGFFVSRFLNMNPVEAGIISACQSGMGGTGDVAILSTADRMNLMPFAQVATRLGGAITVITMTAILRMLF
Atome Classification :
(20 SA)
-------------.........----10.....---...--20........30.-....--...40....-----.----...50..---------......-------60....--------....70........80--.....--------------------.-..90....--.--...100.......110-----.........120.......-130..--..---...140-----...---....150.-------....-..160...-----------------------------.-...170----.-------..-.--.....180.......190.......200.....-..210.-......220.......-------230.....--..240.......250.......260.-......-------270.......280......---.--290......--------.300---.....-..-----------310..-..-----...320------...-.....-330.......340--........------.350-........360.......370........-380.---....--..----390..-..-------...400....-...410.......420..-.....------430......-.440...---------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MA
D
V
K
V
VNN----EDSRG
Q
K
---
Q
DL--
K
A
K
L
F
H
I
K
IGSV
P
-
L
P
V
Y
--
V
C
L
A
L
L
I
L
L
-----
A
----
G
F
L
Q
KL
P
---------
V
N
M
L
G
G
-------
F
A
V
I
L
T
--------
M
G
W
F
L
G
T
IGASIPGFK--NFG
G
P
--------------------
A
-
I
L
S
L
L
V
P
S
--
I
--
L
V
F
F
N
L
I
N
K
N
V
L
E
S
-------
T
N
M
L
M
K
QA
N
F
L
Y
F
Y
I
A
C
L
V-S
G
S
IL--GM---
N
R
K
M
L
I
-----
Q
G
L
---
L
R
M
I
F
P
M
L
-------
L
G
M
V
-
C
A
M
M
V
G
T
F
-----------------------------
V
-
G
V
I
L------G-------LE-W--R
H
T
L
F
Y
I
V
T
P
V
LAGGIGEG
I
L
P
L
SLG
Y
S
S
ITG
V
-
A
S
E
Q
L
V
-
A
Q
L
I
P
A
T
I
I
G
N
F
F
A
I
L
-------
C
T
A
L
L
N
R
L--GEKKPHLSGQ
G
Q
L
V
R
LNKGE
D
M
S
D
I
I
-ADHSGP-------I
D
V
K
KMG
G
G
V
L
T
A
C
S
L
F
I
F
---
G
--
H
L
L
Q
Q
LTGF--------P
G
P
V
---
L
M
I
V
A
-
A
A
-----------
I
L
K
Y
I
-
N
V-----IPRET-------Q
N
G
-
A
K
Q
L
Y
-
K
F
I
SGNFT
F
P
L
----
M
AG
L
G
L
L
Y
------I
P
-
L
-
K
D
V
V
A
T
L
S
I
Q
Y
F
I
V
V
I
S
V
V
F
-
T
V
I
S
V
G
F
F
-
V
S
R
F
---LNMN--P
V
----
E
A
G
I
I
-
S
A
-------
C
Q
SGMGGTG
D
-
V
A
I
L
STADRMNLM
P
F
A
Q
V
-
A
T
RLG------G
A
I
T
V
I
T
M
T
-
A
I
L
R
M
LF---------------------
46
Fugue
82.35
18%
-122
- C8 -
4CZB
1
NAH1_METJA
A:
[1-415]
-------------
M
E
L
M
M
A
I
G
Y
----
L
G
L
A
L
V
L
---
G
S
L
--
V
A
K
I
A
E
-
K
L
K
I
P
D
-
I
P
L
L
--
L
L
L
G
L
I
I
-------
G
----
P
F
L
Q
I
I
P
-------------------------------------------
S
D
S
A
M
E
I
F
E
--
Y
A
G
P
I
--------------------
G
-
L
I
F
I
L
L
G
G
--
A
--
F
T
M
----
R
I
S
L
L
K
R
-------
V
I
K
T
V
V
R
L
D
T
I
T
F
L
I
T
L
L
I
-
S
G
F
I
F
--
N
M
---
V
L
N
L
P
Y
-----
T
S
P
---
V
G
Y
L
F
G
A
I
-------
T
A
A
T
-
D
P
A
--------------------------------------------------------------
T
L
I
P
V
F
S
R
V
R
T
N
P
E
V
A
I
T
L
E
A
E
S
I
F
N
D
P
L
G
I
-
V
S
T
S
V
I
-
L
G
L
F
G
L
F
S
S
S
N
-------------------
P
--
L
I
D
L
I
T
L
A
G
G
A
I
V
V
G
L
L
L
A
K
I
Y
E
K
I
I
-
I
H
C
D
F
H
----------
E
Y
V
A
P
L
V
L
G
G
A
M
L
L
L
Y
---
V
G
D
D
L
L
P
S
I
C
G
Y
--------
G
F
S
G
---
Y
M
A
V
A
-
I
M
-----------
G
L
Y
L
G
-
D
A
-----
L
F
R
A
D
-------
D
I
D
-
Y
K
Y
I
V
-
S
F
C
D
D
L
S
L
L
A
R
----
V
F
I
F
V
F
L
G
------
A
C
-
I
K
L
S
M
L
E
N
Y
F
I
P
G
L
L
V
A
L
G
S
I
F
-
L
A
R
P
L
G
V
F
-
L
G
L
I
---
G
S
K
H
--
S
F
----
K
E
K
L
Y
-
F
A
L
E
G
P
R
G
V
V
P
A
A
L
A
V
T
V
G
-
I
E
I
L
K
N
A
D
K
I
P
A
S
I
T
K
Y
I
T
P
T
D
I
A
------
G
T
I
I
I
G
T
F
M
-
T
I
L
L
S
V
I
L
E
A
S
W
A
G
M
L
A
L
K
L
LGE-----
53
Fugue
82.04
19%
-138
- C7 -
4Q9T
-
?
A:
[12-446]
-----------------
T
K
I
L
T
----
E
T
E
K
Y
S
V
---
T
K
L
--
S
T
D
L
S
F
L
P
F
E
G
----------------
L
V
-----
D
----
T
A
L
Q
K
A
L
---------
V
N
D
L
D
H
-------
I
Y
I
-------------
W
N
Y
N
S
I
Q
K
D
T
P
I
C
K
I
-
S
L
H
S
S
--------------------
P
-
P
I
C
L
F
T
S
S
--
I
--
N
G
I
C
I
I
N
K
K
N
------------------
S
Q
F
L
Y
F
E
----
D
-
I
S
T
I
N
--
N
L
---
A
H
V
L
D
L
KLKDN
E
N
I
---
T
S
T
I
N
C
E
P
-------
S
G
I
I
-
I
A
T
S
L
G
R
V
-----------------------------
L
-
F
I
T
I
------
K
DSTGK
P
K
L
E
-
L
--
K
Q
Q
L
I
K
P
Q
N
S
F
F
F
R
N
L
D
S
S
K
E
I
I
S
L
K
K
G
P
I
V
G
K
-
G
E
R
L
L
Y
-
I
T
T
R
G
G
S
L
Q
I
W
Q
L
S
I
N
------------------------
S
K
S
F
K
R
L
E
I
N
I
Y
E
H
V
L
D
S
L
-
Q
D
L
Y
-------------
P
F
A
H
G
T
L
----
A
F
L
D
---
S
--
H
P
I
Y
S
D
T
S
S
--------
A
H
L
T
---
L
A
S
I
S
N
G
N
-----------
E
I
Y
Y
L
M
I
T
-----
V
I
L
D
E
-------
K
T
N
-
S
F
Q
I
F
-
S
I
Y
K
L
N
T
Y
F
T
K
STVD
L
N
H
K
P
Q
L
F
------
I
P
N
A
-
L
D
S
I
V
S
P
T
L
S
V
Y
V
L
F
N
N
A
V
V
M
T
Q
I
S
S
K
L
---
D
S
S
---
F
P
L
R
--
R
K
----
W
E
D
I
I
-
R
F
--------------
N
K
D
-
V
E
I
I
G
S
G
Y
S
--------------
T
------
D
S
I
Y
V
I
C
K
D
M
G
V
L
K
I
A
S
H--------------------
49
Fugue
79.51
15%
-131
- C4 -
4U1C
-
EIF3C_YEAST
C:
[6-549]
-----------QE
D
F
F
T
R
L
Q
T
I
----
I
D
S
R
G
K
K
TVN
Q
Q
S
--
L
I
S
T
L
E
E
L
L
T
V
A
E
-
K
P
Y
E
--
F
I
M
A
Y
L
T
L
I
-----
P
----
S
R
F
D
A
S
A
NLSY-----
Q
P
I
D
Q
W
-------
K
S
S
F
N
D
--------
I
S
K
L
L
S
I
L
D
Q
T
I
D
T
Y
Q
VN
E
F
A
D
P
IDFIEDEPKEDSDGVKRILG
S
-
I
F
S
F
V
E
R
L
--
D
--
D
E
F
M
K
S
L
L
N
I
D
P
H
S
-------
S
D
Y
L
I
R
L
R
D
E
Q
S
I
Y
N
L
I
L
R
-
T
Q
L
Y
F
--
E
A
TLK
D
E
H
D
L
E
-----
R
A
L
---
T
R
P
F
V
K
R
L
DHIYYKS
E
N
L
I
-
K
I
M
E
T
A
A
W
NIIPAQFKSKFTSKDQLDSADYVDNLIDG
L
-
S
T
I
L
SKQNNI
A
-------
V
Q
-
K
--
R
A
I
L
Y
N
I
Y
Y
T
A
L
N
K
D
F
Q
T
A
K
D
M
L
L
T
S
Q
V
Q
T
N
I
N
-
Q
F
D
S
S
L
-
Q
I
L
F
N
R
V
V
V
Q
L
G
L
S
A
F
KLCLIEE
C
H
Q
I
L
N
D
L
LS
S
S
H
L
R
E
I
L
G
Q
Q
S
L
H
R
I
S
L
N
S
S
N
N
A
S
A
-
D
E
R
A
R
Q
CLPYHQH
I
N
L
D
L
I
D
V
V
F
L
T
C
S
L
L
I
E
I
---
P
--
R
M
T
A
F
Y
S
G
I
KVKRIPYS
P
K
S
I
---
R
R
S
L
E
-
H
Y
DKLSFQGPPET
L
R
D
Y
V
-
L
F
-----
A
A
K
S
M
-------
Q
K
G
N
W
R
D
S
V
-
K
Y
L
R
E
I
K
S
W
A
L
----
L
P
N
M
E
T
V
L
------
N
S
-
L
-
T
E
R
V
Q
V
E
S
L
K
T
Y
F
F
S
F
K
R
F
Y
-
S
S
F
S
V
A
K
L
-
A
E
L
F
------
D
--
L
P
----
E
N
K
V
V
-
E
V
-------
L
Q
S
V
I
A
E
L
E
I
-
P
A
K
L
N
D
E
K
T
I
F
V
V
E
K
G
D
E
-
I
T
K
L
E
------
E
A
M
V
K
L
--------------------------------
51
Fugue
76.19
18%
-118
- C9 -
3TIJ
7
?
A:
[8-422]
S
L
F
M
S
L
I
G
M
A
V
L
L
G
I
A
V
L
L
S
S
N
----
R
K
A
I
N
L
R
---
T
V
G
--
G
A
F
A
I
Q
F
S
L
G
A
F
I
-
L
Y
V
P
--
W
G
Q
E
L
L
R
G
F
-----
S
----
D
A
V
S
N
V
I
---------
N
Y
G
N
D
G
-------
T
S
F
L
F
--------------
G
G
L
V
S
G
-
K
M
F
E
--
V
F
G
G
G
--------------------
G
F
I
F
A
F
R
V
L
P
--
T
--
L
I
F
F
S
A
L
-
I
S
V
L
Y
Y
-------
L
G
V
M
Q
W
V
I
R
I
L
G
G
G
L
Q
K
A
L
-
G
T
S
--------------
R
-----
A
E
S
---
M
S
A
A
A
N
I
F
-------
V
G
Q
T
E
A
P
L
V
V
R
P
F
-----------------------------
V
-
P
K
M
T
--------------------
Q
S
E
L
F
A
V
M
C
G
G
L
A
S
I
A
----
G
G
V
L
A
G
Y
A
S
M
-
G
V
-
K
I
E
Y
L
V
-
A
A
S
F
M
A
A
P
G
G
L
L
F
A
K
L
-------
M
M
P
E
T
E
K
P
--
Q
D
K
P
A
N
-----
V
I
D
A
A
A
G
G
A
S
A
G
L
Q
L
-
A
L
N
V
G
A
-------
M
L
I
A
F
I
G
L
I
A
L
I
N
G
M
L
G
G
I
---
G
--
G
W
F
G
M
P
E
L
K
--------
L
E
M
L
---
L
G
W
L
F
-
A
P
-----------
L
A
F
L
I
-
G
V
-----
P
W
N
E
A
-------
T
V
A
-
G
E
F
I
G
-
L
K
T
V
A
N
---
E
F
----
V
A
Y
S
Q
F
A
P
------
Y
L
-
T
-
E
A
A
P
V
V
L
S
-----
E
K
T
K
A
I
I
-
S
F
A
L
C
G
F
-----------------------
A
N
L
-
S
S
-------
I
A
I
L
L
G
G
L
G
S
-
L
A
----
P
K
R
R
G
D
I
A
R
M
G
V
-
K
A
V
I
A
------
G
T
L
S
N
L
M
A
A
-
T
I
A
G
F
F
L
---------------------
52
Fugue
74.35
16%
-123
- C6 -
4EPQ
1
?
A:
[34-472]
---------------
D
Y
Q
F
P
L
P
----
Q
K
N
S
E
L
W
---
I
I
Q
--
K
K
T
L
Q
D
L
S
S
G
K
Q
K
-
L
D
S
F
--
Q
S
L
E
S
I
L
E
I
-----
L
R
DSK
N
Q
N
D
E
K
Y
---------
F
N
L
K
A
V
-------
F
E
Q
L
-------------------------
D
--
K
E
E
Q
T
--------------------
Y
-
F
L
E
Q
F
I
P
K
--
I
--
C
Q
L
V
L
K
I
K
K
K
Q
L
K
N
Q
IPKESK
I
Y
E
A
A
F
S
R
E
E
I
S
Y
Y
V
S
C
M
F
-
L
C
I
L
K
--
D
Q
---
D
R
K
--
I
-----
Y
K
D
---
F
R
L
I
Y
L
K
D
-------
L
V
----------------------------------------
Q
-
Q
I
N
I
------
R
-------
R
Q
-
E
--
K
I
K
C
F
Y
E
Y
L
K
Q
A
L
D
------------
F
S
--
E
K
E
-
S
K
E
V
V
I
-
F
Q
R
I
N
C
G
Q
L
E
D
Y
E
N
W
V
-------
D
K
L
K
A
I
K
L
----
K
N
V
Q
L
T
D
-
D
K
L
I
E
D
F
P
G
T
L
Q
V
D
F
A
N
C
D
I
G
G
G
-------
I
L
G
N
G
L
---
V
Q
E
E
I
R
F
C
V
C
---
P
--
E
M
L
V
S
L
L
V
F
--------
D
Q
S
M
EAN
E
V
I
I
M
-
K
G
-----------
I
K
Q
Y
S
-
D
Y
QGYSN
S
F
R
F
V
-------
K
M
G
-
N
S
K
I
Q
-
K
Q
K
R
T
N
-
P
Q
T
I
----
L
A
I
D
A
L
C
F
NSSDNQ
F
S
-
E
-
V
N
V
S
R
E
L
N
K
S
Y
M
G
F
K
Q
E
D
Q
L
-
K
T
I
S
T
G
K
W
G
C
G
A
F
---
L
G
V
F
--
D
L
----
K
F
A
I
Q
-
W
I
-------
A
S
S
R
S
N
K
--
K
-
M
I
I
C
T
F
Q
D
E
Q
T
T
K
Q
I
Q
Q
V
-
F
D
L
Y
K
------
Q
K
N
A
S
I
F
L
K
-
L
V
M
D
Y
P
N
SKYMEDYT
L
L
E
Y
L
I
E
L
G
K
E
KA
45
Fugue
62.82
13%
-127
- C8 -
4L8T
-
A:
[64-447]
------------E
Y
L
G
M
L
Q
Y
K
R
----
E
D
E
A
K
L
I
---
Q
N
L
IL
D
L
K
P
R
G
V
V
V
N
M
I
P
G
L
P
A
H
--
I
L
F
M
C
V
R
Y
A
D
S
L
ND
A
----
N
M
L
K
S
L
M
---------
N
S
T
I
N
G
-------
I
K
Q
V
V
K
E
H
L
ED
F
E
M
L
S
F
W
L
S
N
T
C
H
F
L
N
C
L
K
--
Q
Y
S
G
E
--------------------
E
-
E
F
-----------------
M
K
H
N
S
P
Q
Q
-------
N
K
N
C
L
N
N
F
D
L
------------------
S
---
E
Y
R
Q
I
L
-----
S
D
V
---
A
I
R
I
Y
H
Q
F
-------
I
I
I
M
-
E
K
N
I
Q
P
I
I
-----------------------------
V
-
P
G
M
L
------
E
-------
Y
E
-
S
--
L
Q
--------------
G
Y
T
M
T
S
V
L
Q
Q
L
S
Y
F
Y
T
T
-
M
C
Q
N
G
L
-
D
P
E
L
V
R
Q
A
V
K
Q
L
F
F
L
I
-------
G
A
V
T
L
N
S
L
--
F
L
R
K
D
M
C
S
C
R
K
G
M
Q
I
R
C
N
I
S
Y
L
E
E
W
L
-
K
D
K
N
------------------------------------
L
Q
N
S
L
A
K
--------
E
T
L
E
---
P
L
S
Q
A
-
A
W
-----------
L
L
Q
----------
V
K
K
T
T
-------
D
S
D
-
A
K
E
I
Y
-
E
R
C
T
-
S
L
S
A
V
Q
----
I
I
K
I
L
N
S
Y
------
T
P
-
I
-
D
D
------------------------------------
F
E
K
--
R
V
----
T
P
S
F
V
-
R
K
-------
V
Q
A
L
L
N
S
R
E
D
S
S
Q
L
M
L
D
T
K
Y
L
F
Q
V
T
F
P
F
T
-
P
S
P
H
A
------
L
E
M
I
Q
I
P
S
S
-
F
K
L
G
F
L
N
RL-------------------
50
Fugue
56.62
9%
-98
* C9 *
2C1L
10
?
A:
[1-358]
-------------
M
N
F
F
S
L
H
P
N
----
V
Y
A
T
G
R
P
---
K
G
L
--
I
G
M
L
E
N
V
W
V
S
N
H
T
-
P
G
E
--------------------------------------------------------------------------------------------------------------------
G
T
--
L
--
Y
L
I
S
G
F
S
N
Y
N
G
G
V
R
-------
F
Y
E
T
F
T
E
H
I
N
Q
G
G
R
V
I
A
I
L
G
G
S
T
S
Q
--
R
L
---
S
S
R
Q
V
V
-----
E
E
L
---
L
N
R
----------------------
G
V
E
-----------------------------
V
-
H
I
I
N
------
R
-------
K
R
-
I
--
L
H
A
K
L
Y
G
T
S
N
--
N
L
G
E
S
L
V
V
S
S
G
N
F
T
G
P
G
M
S
Q
N
-
I
E
A
S
L
L
-
L
D
N
N
T
T
Q
S
M
G
F
S
W
N
D
M
-------
I
S
E
M
L
N
Q
N
--
W
H
I
H
N
M
T
---------
N
A
T
D
A
S
P
G
W
N
-
L
L
Y
D
E
R
-------
T
T
N
L
T
L
D
E
T
E
R
V
T
L
I
V
T
L
G
---
H
--
A
D
T
A
R
I
Q
A
A
--------
P
G
T
-------
T
A
-
G
Q
-----------
G
T
Q
Y
F
-
W
L
-----
S
-
K
D
S
-------
Y
D
F
-
F
P
P
L
T
-
I
R
N
R
R
G
T
K
A
T
Y
----
S
S
L
I
N
M
N
Y
------
I
D
-
I
-
N
Y
T
D
T
Q
C
R
V
T
F
E
------
A
E
-
N
N
F
D
F
R
L
G
-
T
G
K
L
---
R
Y
T
G
--
V
A
----
K
S
N
D
I
-
A
A
-------
I
T
R
V
G
D
S
D
Y
E
-
L
R
I
I
K
Q
G
T
P
E
H
S
Q
L
D
P
Y
A
-
V
S
F
I
G
NRG
K
R
F
G
Y
I
S
N
E
E
F
G
-
R
I
I
G
V
T
F
---------------------
44
Fugue
55.04
15%
-110
- C9 -
4IC4
-
A:
[26-397]
--------------
K
S
V
T
R
R
N
D
IPEA
A
A
S
P
P
S
L
---
L
S
F
--
L
R
K
N
V
G
K
D
L
S
S
I
A
-
M
P
V
T
SN
E
P
I
S
I
L
Q
L
I
-----
S
----
E
T
F
E
Y
A
P
---------
L
L
T
K
A
T
Q
RPD
P
I
T
F
V
S
A
F
A
--------
I
S
F
L
S
I
Y
R
D
K
T
R
T
L
R
K
--
P
F
N
P
L
--------------------
L
-
A
E
T
F
E
L
I
R
--
E
--
D
M
G
F
R
L
I
S
E
K
V
S
H
R
-------
P
P
V
F
A
F
F
A
E
H
L
D
W
E
C
S
Y
T
V
-
T
P
S
Q
K
F
W
G
K
---
S
I
E
L
N
N
-----
E
G
I
---
L
R
L
K
F
K
T
T
-------
G
E
L
F
-
E
W
T
Q
P
T
T
I
-----------------------------
L
K
N
L
I
A
------
G
-------
E
R
-
Y
--
M
E
P
V
N
E
F
E
V
H
S
S
K
G
D
K
S
H
I
L
F
D
K
A
G
M
F
S
G
-----
R
S
E
G
F
K
-
V
S
I
I
P
P
P
--------------------------
S
S
N
R
K
K
E
T
L
A
G
K
W
T
Q
S
L
A
N
E
T
T
H
E
T
I
-
W
E
V
G
D
L
-------
V
S
N
P
K
K
K
Y
G
------
F
T
K
F
---
T
--
A
N
L
N
E
I
T
E
I
--------
E
K
G
N
---
L
P
P
T
D
-
S
R
-----------
L
R
P
D
I
-
R
A
-----
Y
E
E
G
N
-------
V
D
K
-
A
E
E
W
K
-
L
K
L
E
Q
L
Q
R
E
R
R
----
N
K
G
--------------------
Q
D
V
E
P
K
Y
F
E
K
V
S
K
N
E
W
-
K
Y
I
-----------------------------------------------
T
G
P
-
K
S
Y
W
E
R
R
K
K
H
D
W
S
D
I
S
Q
L
-
W
------------------------------------------------
35
HHSearch
51.39
15%
-121
- C8 -
1ZCD
-
NHAA_ECOLI
A:
[64-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
A
L
M
A
V
F
F
-
L
L
V
G
L
--
E
V
---
K
R
E
L
M
Q
-----
G
S
L
ASL
R
Q
A
A
F
P
V
I
-------
A
A
I
G
-
G
-
M
I
V
P
A
L
-----------------------------
L
-
Y
L
A
F
------
N
-------
Y
A
D
P
I-
T
R
E
G
W
A
I
---
P
A
A
T
D
I
A
F
A
L
G
V
L
A
----
L
-
L
G
S
R
V
P
L
A
L
K
-
I
F
L
M
A
L
A
I
I
D
D
L
G
A
I
I
-------
I
I
A
L
F
Y
T
N
--
D
L
S
-
M
A
S
L
G
V
A
A
V
A
I
A
V
L
A
V
L
--
N
-
L
-
C
G
A
R
R
T
-------
G
V
Y
--
I
L
V
G
----
V
V
L
-
W
T
---
A
-----
V
L
K
S
G
V
--------
H
A
T
L
---
A
G
V
I
V
-
G
F
-----------
F
------------
I
P
L
K
E
KHGRS
P
A
K
R
L
-
E
H
V
L
H
-
P
W
V
A
Y
L
I
L
P
L
F
A
---
F
A
N
A
G
V
S
-------
L
Q
-
G
-
V
T
L
D
G
L
T
S
I
L
P
L
G
I
I
A
G
L
L
I
-
G
K
P
L
G
I
S
L
-
F
C
W
L
ALR
L
K
L
A
HL
P
E
GTTY
Q
Q
I
M
V
V
G
--------
I
L
C
G
I
G
F
T
M
S
-
I
F
I
A
S
L
A
F
G
S
V
D
P
E
L
I
N
W
-
A
K
L
G
I
------
L
V
G
S
I
S
S
A
V
-
I
G
Y
S
W
L
R
---------------------
1
PsiBlast_PDB
50.82
22%
-123
- C5 -
4UT7
-
?
H:
[13-116]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
G
G
S
L
R
L
S
C
A
A
S
G
F
SYS
N
--
H
W
M
H
W
V
R
Q
A
--------
P
G
K
G
---
L
V
W
V
S
-----------------------------
R
I
N
-------
S
D
G
-
S
T
R
N
Y
A
D
F
V
K
G
R
F
T
I
S
R
----
D
N
A
E
N
T
L
Y
------
L
E
-
M
-
N
S
L
T
A
D
D
T
A
V
Y
Y
C
V
R
D
G
V
R
F
-
Y
Y
D
S
T
G
Y
Y
-
P
D
S
F
---
F
K
Y
G
--
M
D
----
V
W
G
Q
G
-
T
T
-------
V
T
V
S
S
G
T
G
G
S
-
G
G
G
G
S
G
G
G
G
-----------------------------------------------------------
5
PsiBlast_PDB
49.01
32%
-76
- C8 -
2XTJ
-
?
A:
[107-171]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
V
-----------------------------
S
-
G
T
L
I
------
G
-------
L
E
-
F
I
R
K
S
Q
L
V
Q
P
V
G
P
L
V
V
------
L
L
P
L
A
G
G
Y
S
R
V
L
N
A
-
A
C
Q
R
L
A
R
A
G
V
V
L
V
T
A
A
G
N
F
R
D
D
A
-------
C
L
Y
S
P
A
S
A
--
P
E
V
I
T
V
G
A
T
N
A
Q
D
Q
P
V
T
L
G
T
L
G
T
N
F
G
-
R
C
V
D
L
F
-------
A
P
G
E
D
I
I
G
A
S
S
D
C
S
T
C
F
V
S
---
Q
--
S
G
T
S
Q
A
A
A
H
--------
V
A
G
I
---
A
A
M
M
L
-
S
A
-----------
E
P
E
L
T
-
L
A
-----
E
L
R
Q
R
-------
L
I
L
-
F
S
A
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
48.83
33%
-43
- C8 -
2P4E
2
PCSK9_HUMAN
A:
[259-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
V
-----------------------------
S
-
G
T
L
I
------
G
-------
L
E
-
F
I
R
K
S
Q
L
V
Q
P
V
G
P
L
V
V
------
L
L
P
L
A
G
G
Y
S
R
V
L
N
A
-
A
C
Q
R
L
A
R
A
G
V
V
L
V
T
A
A
G
N
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
47.54
32%
-84
- C8 -
2W2N
-
?
A:
[107-171]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
V
-----------------------------
S
-
G
T
L
I
------
G
-------
L
E
-
F
I
R
K
S
Q
L
V
Q
P
V
G
P
L
V
V
------
L
L
P
L
A
G
G
Y
S
R
V
L
N
A
-
A
C
Q
R
L
A
R
A
G
V
V
L
V
T
A
A
G
N
F
R
D
D
A
-------
C
L
Y
S
P
A
S
A
--
P
E
V
I
T
V
G
A
T
N
A
Q
D
Q
P
V
T
L
G
T
L
G
T
N
F
G
-
R
C
V
D
L
F
-------
A
P
G
E
D
I
I
G
A
S
S
D
C
S
T
C
F
V
S
---
Q
--
S
G
T
S
Q
A
A
A
H
--------
V
A
G
I
---
A
A
M
M
L
-
S
A
-----------
E
P
E
L
T
-
L
A
-----
E
L
R
Q
R
-------
L
I
H
-
F
S
A
K
D
-
V
I
N
E
A
W
F
P
E
D
Q
----
R
V
L
T
P
N
L
V
------
A
A
-
L
-
P
P
---------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
47.41
31%
-119
- C8 -
4P6X
2
GCR_HUMAN
E:
[21-101]
-------------------------------------------------------------------
V
L
Y
-----
A
----
G
Y
D
S
S
V
P
DSTWRIMTT
L
N
M
L
G
G
-------
R
Q
V
I
A
A
--------
V
K
W
-----
A
K
A
I
P
G
F
R
--
N
L
H
L
D
--------------------
D
-
Q
M
T
L
L
Q
Y
S
WM
A
--
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
-------
S
------
A
N
L
L
Y
F
A
P
D
L
I
I
-
N
E
Q
R
M
--
T
L
---
P
C
M
Y
D
Q
-----
C
K
H
---
M
L
Y
V
S
S
E
L
-------
H
R
L
Q
-
V
S
Y
E
E
Y
L
C
-----------------------------
M
-
K
V
L
L
------
L
-------
L
S
-
T
--
I
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
-
S
S
Q
N
W
Q
-
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
-------
E
N
L
L
N
Y
C
F
--
Q
T
F
L
D
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
-
Y
S
N
G
N
I
-------
K
K
L
L
F
H
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
47.39
31%
-123
- C8 -
4P6X
2
GCR_HUMAN
A:
[21-101]
-------------------------------------------------------------------
V
L
Y
-----
A
----
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
-------
R
Q
V
I
A
A
--------
V
K
W
-----
A
K
A
I
P
G
F
R
--
N
L
H
L
D
--------------------
D
-
Q
M
T
L
L
Q
Y
S
--
W
M
A
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
-------
S
------
A
N
L
L
Y
F
A
P
D
L
I
I
-
N
E
Q
R
M
--
T
L
---
P
C
M
Y
D
Q
-----
C
K
H
---
M
L
Y
V
S
S
E
L
-------
H
R
L
Q
-
V
S
Y
E
E
Y
L
C
-----------------------------
M
-
K
V
L
L
------
L
-------
L
S
-
T
--
I
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
-
S
S
Q
N
W
Q
-
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
-------
E
N
L
L
N
Y
C
F
--
Q
T
F
L
D
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
-
Y
S
N
G
N
I
-------
K
K
L
L
F
H
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
47.34
32%
-85
- C8 -
4NMX
-
?
B:
[107-171]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
V
-----------------------------
S
-
G
T
L
I
------
G
-------
L
E
-
F
I
R
K
S
Q
L
V
Q
P
V
G
P
L
V
V
------
L
L
P
L
A
G
G
Y
S
R
V
L
N
A
-
A
C
Q
R
L
A
R
A
G
V
V
L
V
T
A
A
G
N
F
R
D
D
A
-------
C
L
Y
S
P
A
S
A
--
P
E
V
I
T
V
G
A
T
N
A
Q
D
Q
P
V
T
L
G
T
L
G
T
N
F
G
-
R
C
V
D
L
F
-------
A
P
G
E
D
I
I
G
A
S
S
D
C
S
T
C
F
V
S
---
Q
--
S
G
T
S
Q
A
A
A
H
--------
V
A
G
I
---
A
A
M
M
L
-
S
A
-----------
E
P
E
L
T
-
L
A
-----
E
L
R
Q
R
-------
L
I
H
-
F
S
A
K
D
-
V
I
N
E
A
W
F
P
E
D
Q
----
R
V
L
T
P
N
L
V
------
A
A
-
L
-
P
P
---------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
46.54
32%
-102
- C8 -
2PMW
-
?
B:
[107-171]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
V
-----------------------------
S
-
G
T
L
I
------
G
-------
L
E
-
F
I
R
K
S
Q
L
V
Q
P
V
G
P
L
V
V
------
L
L
P
L
A
G
G
Y
S
R
V
L
N
A
-
A
C
Q
R
L
A
R
A
G
V
V
L
V
T
A
A
G
N
F
R
D
D
A
-------
C
L
Y
S
P
A
S
A
--
P
E
V
I
T
V
G
A
T
N
A
Q
D
Q
P
V
T
L
G
T
L
G
T
N
F
G
-
R
C
V
D
L
F
-------
A
P
G
E
D
I
I
G
A
S
S
D
C
S
T
C
F
V
S
---
Q
--
S
G
T
S
Q
A
A
A
H
--------
V
A
G
I
---
A
A
M
M
L
-
S
A
-----------
E
P
E
L
T
-
L
A
-----
E
L
R
Q
R
-------
L
I
H
-
F
S
A
K
D
-
V
I
N
E
A
W
F
P
E
D
Q
----
R
V
L
T
P
N
L
V
------
A
A
-
L
-
P
P
S
G
W
Q
L
F
C
R
T
V
W
S
A
H
S
G
P
T
-
R
M
A
T
A
V
A
R
-
C
A
P
D
---
E
E
L
L
--
S
C
----
S
S
F
S
R
-
S
G
-------
K
R
R
G
E
R
M
E
A
Q
-
G
G
K
L
V
C
R
A
H
N
A
F
G
G
E
G
V
Y
-
A
I
A
R
C
------
C
L
L
P
Q
A
N
C
S
-
V
H
T
A
P
P
A
---------------------
6
PsiBlast_PDB
46.42
32%
-84
- C8 -
2W2M
-
PCSK9_HUMAN
A:
[107-171]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
V
-----------------------------
S
-
G
T
L
I
------
G
-------
L
E
-
F
I
R
K
S
Q
L
V
Q
P
V
G
P
L
V
V
------
L
L
P
L
A
G
G
Y
S
R
V
L
N
A
-
A
C
Q
R
L
A
R
A
G
V
V
L
V
T
A
A
G
N
F
R
D
D
A
-------
C
L
Y
S
P
A
S
A
--
P
E
V
I
T
V
G
A
T
N
A
Q
D
Q
P
V
T
L
G
T
L
G
T
N
F
G
-
R
C
V
D
L
F
-------
A
P
G
E
D
I
I
G
A
S
S
D
C
S
T
C
F
V
S
---
Q
--
S
G
T
S
Q
A
A
A
H
--------
V
A
G
I
---
A
A
M
M
L
-
S
A
-----------
E
P
E
L
T
-
L
A
-----
E
L
R
Q
R
-------
L
I
H
-
F
S
A
K
D
-
V
I
N
E
A
W
F
P
E
D
Q
----
R
V
L
T
P
N
L
V
------
A
A
-
L
-
P
P
S
--------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
46.36
32%
-85
- C8 -
2W2Q
-
PCSK9_HUMAN
A:
[107-171]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
V
-----------------------------
S
-
G
T
L
I
------
G
-------
L
E
-
F
I
R
K
S
Q
L
V
Q
P
V
G
P
L
V
V
------
L
L
P
L
A
G
G
Y
S
R
V
L
N
A
-
A
C
Q
R
L
A
R
A
G
V
V
L
V
T
A
A
G
N
F
R
D
D
A
-------
C
L
Y
S
P
A
S
A
--
P
E
V
I
T
V
G
A
T
N
A
Q
D
Q
P
V
T
L
G
T
L
G
T
N
F
G
-
R
C
V
D
L
F
-------
A
P
G
E
D
I
I
G
A
S
S
H
C
S
T
C
F
V
S
---
Q
--
S
G
T
S
Q
A
A
A
H
--------
V
A
G
I
---
A
A
M
M
L
-
S
A
-----------
E
P
E
L
T
-
L
A
-----
E
L
R
Q
R
-------
L
I
H
-
F
S
A
K
D
-
V
I
N
E
A
W
F
P
E
D
Q
----
R
V
L
T
P
N
L
V
------
A
A
-
L
-
P
P
S
--------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
46.15
33%
-82
- C8 -
4OV6
1
?
E:
[107-166]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
V
-----------------------------
S
-
G
T
L
I
------
G
-------
L
E
-
F
IR
K
S
Q
L
V
Q
P
V
G
P
L
V
V
------
L
L
P
L
A
G
G
Y
S
R
V
L
N
A
-
A
C
Q
R
L
A
R
A
G
V
V
L
V
T
A
A
G
N
F
R
D
D
A
-------
C
L
Y
S
P
A
S
A
--
P
E
V
I
T
V
G
A
T
N
A
Q
D
Q
P
V
T
L
G
T
L
G
T
N
F
G
-
R
C
V
D
L
F
-------
A
P
G
E
D
I
I
G
A
S
S
D
C
S
T
C
F
V
S
---
Q
--
S
G
T
S
Q
A
A
A
H
--------
V
A
G
I
---
A
A
M
M
L
-
S
A
-----------
E
P
E
L
T
-
L
A
-----
E
L
R
Q
R
-------
L
I
H
-
F
S
A
K
D
-
V
I
N
E
A
W
F
P
E
D
Q
----
R
V
L
T
P
N
L
V
------
A
A
-
L
-
P
----------------------------------------------------------------------------------------------------------------------------------------------