@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1910: (2015-12-11 )
MAVLILGGAGYIGSHMVDQLITQGKEKVIVVDNLVTGHRQAVHSDAIFYEGDLSDKTFMRQVFRENPDVDAVIHFAAFSLVAESMENPLKYFDNNTAGMIKLLEVMNECDIKNIVFSSTAATYGIPEQVPILETAPQNPINPYGESKLMMETIMKWADQAYGIKFVALRYFNVAGDKPDGSIGEDHKPETHLLPIILQVAQGVRDKIMIFGDDYNTPDGTNVRDYVHPFDLADAHILAVDYLRQGNESNVFNLGSSTGFSNLQMLEAARRITGKEIPAQKAARRPGDPDTLIASSEKARQILGWEPKFDNIDKIISSAWAWHSSHPNGYED
Atome Classification :
(55 SA)
-.........10........20..-......30......------.---------.------------40.-----------.-------.----.-----------------------..-------..50........60........70........80........90........100....--...110.......120..----...--.---.130.....-.-.140........150..------------.---....-160.....--...-.170.......180....-.-.-.190......-----..200-----..----....-.210.......220.......230.......240..------...----.-.------250.......260.......270.......280.......290.......300.......310........320.......330-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
A
V
L
I
LGG
A
G
Y
I
G
S
H
M
V
D
Q
L
I
TQ-GK
E
K
V
I
V
V
DNLVTG------
H
---------
R
------------
Q
AV-----------H-------S----D-----------------------
A
I
-------
F
YEGDLS
D
K
T
F
M
R
Q
V
F
RENP
D
V
D
A
V
I
H
F
A
A
F
S
L
V
A
E
S
M
E
N
P
L
K
Y
FDNN
T
A
G
M
I
K
L
L
E
V
M
--
N
ECDIK
N
I
V
FSSTAATYG----IPE--Q---VPILETAPQ-N-PI-NPYGE
S
K
L
M
M
E
T
I
M
------------
K
---WA
D
Q
-A--Y
G
I
K
F
--
V
A
L
-
R
Y
F
NVAGDKPDGSIGEDH-K-P-E
T
H
-
L
L
P
I
I
L
-----
Q
V
A
QG-----VR----
D
K
I
M
-
I
F
GDDYNTPDGTN
V
R
DYVHPFDLAD
A
H
I
L
A
V
D
Y
L
RQ------GNE----S-
N
------
V
F
NLGSSTGF
S
N
L
Q
M
L
E
A
A
R
R
ITGKEI
P
A
Q
K
AARRPGDPD
T
L
IA
S
S
E
K
A
R
Q
ILGWEPKFD
N
I
-
D
K
I
I
S
S
A
W
AWHSSHPNGYED------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
97.59
53%
-99
- C1 -
2C20
2
?
D:
[3-329]
--
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
L
-
S
V
V
V
V
D
N
L
Q
T
G
------
H
---------
E
------------
D
A
I
-----------
T
-------
E
----
G
-----------------------
A
K
-------
F
Y
N
G
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
-
N
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
--
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
----
E
V
D
--
V
---
D
L
I
T
E
E
T
M
T
-
N
-
P
T
-
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
------------
H
---
W
Y
S
Q
-
A
--
S
N
L
R
Y
--
K
I
F
-
R
Y
F
N
V
A
G
A
T
P
N
G
I
I
G
E
D
H
-
R
-
P
-
E
T
H
-
L
I
P
L
V
L
-----
Q
V
A
L
G
-----
Q
R
----
E
K
I
M
-
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
------
G
G
E
----
S
-
D
------
F
Y
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
-
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
94.63
54%
-97
- C1 -
2C20
2
?
A:
[2-329]
-
N
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
-
L
S
V
V
V
V
D
N
L
Q
T
G
------
H
---------
E
------------
D
A
I
-----------
T
-------
E
----
G
-----------------------
A
K
-------
F
Y
N
G
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
-
N
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
--
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
----
E
V
D
--
V
---
D
L
I
T
E
E
T
M
T
-
N
-
P
T
-
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
------------
H
---
W
Y
S
Q
-
A
--
S
N
L
R
Y
--
K
I
F
-
R
Y
F
N
V
A
G
A
T
P
N
G
I
I
G
E
D
H
-
R
-
P
-
E
T
H
-
L
I
P
L
V
L
-----
Q
V
A
L
G
-----
Q
R
----
E
K
I
M
-
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
------
G
G
E
----
S
-
D
------
F
Y
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
-
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
94.41
53%
-96
- C1 -
2C20
2
?
B:
[3-329]
--
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
L
-
S
V
V
V
V
D
N
L
Q
T
G
------
H
---------
E
------------
D
A
I
-----------
T
-------
E
----
G
-----------------------
A
K
-------
F
Y
N
G
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
-
N
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
--
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
----
E
V
D
--
V
---
D
L
I
T
E
E
T
M
T
-
N
-
P
T
-
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
------------
H
---
W
Y
S
Q
-
A
--
S
N
L
R
Y
--
K
I
F
-
R
Y
F
N
V
A
G
A
T
P
N
G
I
I
G
E
D
H
-
R
-
P
-
E
T
H
-
L
I
P
L
V
L
-----
Q
V
A
L
G
-----
Q
R
----
E
K
I
M
-
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
------
G
G
E
----
S
-
D
------
F
Y
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
-
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.02
53%
-97
- C1 -
2C20
2
?
A:
[3-329]
--
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
L
-
S
V
V
V
V
D
N
L
Q
T
G
------
H
---------
E
------------
D
A
I
-----------
T
-------
E
----
G
-----------------------
A
K
-------
F
Y
N
G
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
-
N
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
--
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
----
E
V
D
--
V
---
D
L
I
T
E
E
T
M
T
-
N
-
P
T
-
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
------------
H
---
W
Y
S
Q
-
A
--
S
N
L
R
Y
--
K
I
F
-
R
Y
F
N
V
A
G
A
T
P
N
G
I
I
G
E
D
H
-
R
-
P
-
E
T
H
-
L
I
P
L
V
L
-----
Q
V
A
L
G
-----
Q
R
----
E
K
I
M
-
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
------
G
G
E
----
S
-
D
------
F
Y
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
-
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
93.75
53%
-98
- C1 -
2C20
2
?
E:
[3-329]
--
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
L
-
S
V
V
V
V
D
N
L
Q
T
G
------
H
---------
E
------------
D
A
I
-----------
T
-------
E
----
G
-----------------------
A
K
-------
F
Y
N
G
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
-
N
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
--
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
----
E
V
D
--
V
---
D
L
I
T
E
E
T
M
T
-
N
-
P
T
-
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
------------
H
---
W
Y
S
Q
-
A
--
S
N
L
R
Y
--
K
I
F
-
R
Y
F
N
V
A
G
A
T
P
N
G
I
I
G
E
D
H
-
R
-
P
-
E
T
H
-
L
I
P
L
V
L
-----
Q
V
A
L
G
-----
Q
R
----
E
K
I
M
-
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
------
G
G
E
----
S
-
D
------
F
Y
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
-
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
93.37
53%
-95
- C1 -
2C20
2
?
F:
[3-329]
--
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
L
-
S
V
V
V
V
D
N
L
Q
T
G
------
H
---------
E
------------
D
A
I
-----------
T
-------
E
----
G
-----------------------
A
K
-------
F
Y
N
G
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
-
N
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
--
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
----
E
V
D
--
V
---
D
L
I
T
E
E
T
M
T
-
N
-
P
T
-
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
------------
H
---
W
Y
S
Q
-
A
--
S
N
L
R
Y
--
K
I
F
-
R
Y
F
N
V
A
G
A
T
P
N
G
I
I
G
E
D
H
-
R
-
P
-
E
T
H
-
L
I
P
L
V
L
-----
Q
V
A
L
G
-----
Q
R
----
E
K
I
M
-
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
------
G
G
E
----
S
-
D
------
F
Y
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
-
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
92.38
53%
-96
- C1 -
2C20
2
?
C:
[3-329]
--
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
-
G
L
-
S
V
V
V
V
D
N
L
Q
T
G
------
H
---------
E
------------
D
A
I
-----------
T
-------
E
----
G
-----------------------
A
K
-------
F
Y
N
G
D
L
R
D
K
A
F
L
R
D
V
F
T
Q
E
-
N
I
E
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
--
D
E
F
K
V
D
K
F
I
F
S
S
T
A
A
T
Y
G
----
E
V
D
--
V
---
D
L
I
T
E
E
T
M
T
-
N
-
P
T
-
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
------------
H
---
W
Y
S
Q
-
A
--
S
N
L
R
Y
--
K
I
F
-
R
Y
F
N
V
A
G
A
T
P
N
G
I
I
G
E
D
H
-
R
-
P
-
E
T
H
-
L
I
P
L
V
L
-----
Q
V
A
L
G
-----
Q
R
----
E
K
I
M
-
M
F
G
D
D
Y
N
T
P
D
G
T
C
I
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
------
G
G
E
----
S
-
D
------
F
Y
N
L
G
N
G
N
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
E
I
P
A
E
V
A
P
R
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
P
R
Y
V
N
V
-
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
85.87
40%
-92
* C1 *
3ENK
2
?
A:
[6-339]
-
G
T
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
-
G
-
Y
D
V
V
I
A
D
N
L
V
N
S
------
K
---------
R
E
A
I
---------
A
R
I
-----------
E
K
I
T----
G
----
K
T----------------------
P
A
-------
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
D
A
H
-
P
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
--
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
G
----
V
P
E
--
R
---
S
P
I
D
E
T
F
P
L
-
S
-
A
T
-
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
------------
R
---
D
V
E
A
A
D
--
P
S
W
R
V
--
A
T
L
-
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
D
P
-
A
G
I
-
P
N
N
-
L
M
P
Y
V
A
-----
Q
V
A
V
G
-----
K
L
----
E
K
L
R
-
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
E
R
------
R
D
A
----
S
-
L
------
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
R
-
D
L
-
E
R
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
84.24
40%
-91
- C1 -
3ENK
2
?
A:
[8-340]
---
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
-
G
Y
D
-
V
V
I
A
D
N
L
V
N
S
------
K
---------
R
------------
E
A
I
-----------
A
R
I
E
K
I
TG
K
----
T
-----------------------
P
A
-------
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
D
A
H
P
-
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
--
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
G
----
V
P
E
--
R
---
S
P
I
D
E
T
F
P
L
-
S
-
A
T
-
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
------------
R
D
V
E
A
A
D
P
-
S
--
W
--
R
V
--
A
T
L
-
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
D
P
-
A
-
G
I
P
N
N
-
L
M
P
Y
V
A
-----
Q
V
A
V
G
-----
K
L
----
E
K
L
R
-
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
E
R
------
R
D
A
----
S
-
L
------
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
R
D
-
L
-
E
R
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
83.71
41%
-92
- C1 -
1UDB
7
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
-
H
D
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
SV
L
---------
P
V
I
-----------
E
-------
R
L
G
G
K
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
-
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
Q
-
P
D
W
S
I
--
A
L
L
-
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
G
I
-
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
-
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
83.05
40%
-91
- C1 -
1Z45
5
GAL10_YEAST
A:
[11-699]
S
K
I
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
V
E
L
I
E
N
-
G
-
Y
D
C
V
V
A
D
N
L
S
N
S
------
T
---------
Y
------------
D
S
V
-----------
A
R
L
E
V
L
T
K
H
----
H
-----------------------
I
P
-------
F
Y
E
V
D
L
C
D
R
K
G
L
E
K
V
F
K
E
Y
K
-
I
D
S
V
I
H
F
A
G
L
K
A
V
G
E
S
T
Q
I
P
L
R
Y
Y
H
N
N
I
L
G
T
V
V
L
L
E
L
M
--
Q
Q
Y
N
V
S
K
F
V
F
S
S
S
A
T
V
Y
G
DATR
F
P
N
--
M
---
I
P
I
P
E
E
C
P
L
-
G
-
P
T
-
N
P
Y
G
H
T
K
Y
A
I
E
N
I
L
------------
N
---
D
L
Y
N
-
S
D
K
K
S
W
K
F
--
A
I
L
-
R
Y
F
N
P
I
G
A
H
P
S
G
L
I
G
E
D
P
-
L
G
I
-
P
N
N
-
L
L
P
Y
M
A
-----
Q
V
A
V
G
-----
R
R
----
E
K
L
Y
-
I
F
------
R
D
G
T
P
I
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
Q
Y
L
E
A
------
Y
N
E
----
N
-
E
G
L
C
R
--
E
W
N
L
G
S
G
K
G
S
T
V
F
E
V
Y
H
A
F
C
K
A
S
G
I
D
L
P
Y
V
L
---------
N
L
T
A
K
P
D
R
A
K
R
E
L
K
W
Q
T
E
L
Q
-
V
-
E
D
S
C
K
D
L
W
K
W
T
T
E
N
P
F
G
Y
Q
L
RG
V
E
A
R
F
SAEDMRYDA
R
F
V
T
I
GAGTR
F
Q
A
T
F
A
NLGASIV
D
L
K
V
NGQSV
V
L
G
Y
EN
E
E
G
Y
L
NPDSAYIGATIGRYANRISKG
K
F
S
L
CN
K
D
Y
Q
L
TVNNGVNANHSSIGSFHR
K
R
F
L
G
P
I
I
Q
NPSKD
V
F
T
A
E
Y
M
L
I
D
N
EKDTEFP
G
D
L
L
V
T
I
Q
Y
T
V
N
VAQK
S
L
E
I
V
Y
K
G
K
L
TAGE
A
T
P
I
N
L
T
N
H
S
Y
F
N
LNKPYGDTIEG
T
E
I
M
V
RSK
K
S
V
D
V
D
KNMIPTG
N
I
V
D
R
EIATFNSTK
P
T
V
L
G
PKNP
Q
F
D
C
C
F
V
VDENAKPSQINTLNNELTLI
V
K
A
F
H
PDSN
I
T
L
E
V
L
S
TEP
T
Y
Q
F
Y
TGDFLSAGYEARQ
G
F
A
I
E
P
G
RYIDAINQENWKDCVTLKNG
E
T
Y
G
S
K
I
V
Y
R
F
S
27
PsiBlast_CBE
82.28
42%
-95
- C1 -
1GY8
2
?
D:
[3-382]
-
M
R
V
L
V
C
G
G
A
G
Y
I
G
S
H
F
V
R
A
L
L
R
D
-
T
N
H
S
V
V
I
V
D
S
L
V
G
T
------
H
---------
G
------------
K
S
D
-----------
H
-------
V
----
E
T
R
E
N
V
A
R
K
L
Q
Q
SDGPKPPWAD
R
Y
A
A
-------
L
E
V
G
D
V
R
N
E
D
F
L
N
G
V
F
T
R
H
G
P
I
D
A
V
V
H
M
C
A
F
L
A
V
G
E
S
V
R
D
P
L
K
Y
Y
D
N
N
V
V
G
I
L
R
L
L
Q
A
M
L
L
H
K
C
D
--
K
I
I
F
S
S
S
A
A
I
F
G
----
N
P
----TNA
E
P
I
D
I
N
A
K
K
-
S
-
P
E
-
S
P
Y
G
E
S
K
L
I
A
E
R
M
I
------------
R
---
D
C
A
E
-
A
--
Y
G
I
K
G
--
I
C
L
-
R
Y
F
N
A
C
G
A
H
E
D
G
D
I
G
E
H
Y
-
Q
-
G
-
S
T
H
-
L
I
P
I
I
L
G
R
V
M
S
D
I
A
-------------
D
K
R
M
P
I
F
G
T
D
Y
P
T
P
D
G
T
C
V
R
D
Y
V
H
V
C
D
L
A
S
A
H
I
L
A
L
D
Y
V
E
K
------
L
G
P
----
N
-
D
KSKY
F
S
V
F
N
L
G
T
S
R
G
Y
S
V
R
E
V
I
E
V
A
R
K
T
T
G
H
P
I
P
V
R
E
C
G
R
R
E
G
D
P
A
Y
L
V
A
A
S
D
K
A
R
E
V
L
G
W
K
P
K
Y
D
T
L
-
E
A
I
M
E
T
S
W
K
F
Q
R
T
H
P
N
G
Y
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
HHSearch
82.10
47%
-91
- C1 -
1GY8
2
?
A:
[3-382]
-
M
R
V
L
V
C
G
G
A
G
Y
I
G
S
H
F
V
R
A
L
L
R
D
T
N
-
H
S
V
V
I
V
D
S
L
V
G
T
------
H
GKSDHVET
R
E
N
V
A
---------
R
K
L
Q
Q
S
DGPKPPWA
D
-------
R
----
Y
-----------------------
A
A
-------
L
E
V
G
D
V
R
N
E
D
F
L
N
G
V
F
T
R
H
G
P
I
D
A
V
V
H
M
C
A
F
L
A
V
G
E
S
V
R
D
P
L
K
Y
Y
D
N
N
V
V
G
I
L
R
L
L
Q
A
M
--
L
L
H
K
C
D
K
I
I
F
S
S
S
A
A
I
F
G
----
N
P
T
MN
A
---
E
P
I
D
I
N
A
K
K
-
S
-
P
E
-
S
P
Y
G
E
S
K
L
I
A
E
R
M
I
------------
R
---
D
C
A
E
-
A
--
Y
G
I
K
G
--
I
C
L
-
R
Y
F
N
A
C
G
A
H
E
D
G
D
I
G
E
H
Y
-
Q
-
G
-
S
T
H
-
L
I
P
I
I
L
-----
G
R
V
M
S
D
I
APD-
D
----
K
R
M
P
-
I
F
G
T
D
Y
P
T
P
D
G
T
C
V
R
D
Y
V
H
V
C
D
L
A
S
A
H
I
L
A
L
D
Y
V
E
K
LGPNDK
S
K
Y
----
F
-
S
------
V
F
N
L
G
T
S
R
G
Y
S
V
R
E
V
I
E
V
A
R
K
T
T
G
H
P
I
P
V
R
E
C
G
R
R
E
G
D
P
A
Y
L
V
A
A
S
D
K
A
R
E
V
L
G
W
K
P
K
Y
-
D
T
L
E
A
I
M
E
T
S
W
K
F
Q
R
T
H
P
N
G
Y
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
81.69
40%
-90
- C1 -
3ENK
2
?
B:
[8-340]
---
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
-
G
Y
D
-
V
V
I
A
D
N
L
V
N
S
------
K
---------
R
------------
E
A
I
-----------
A
RIEKITG
K
----
T
-----------------------
P
A
-------
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
D
A
H
P
-
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
--
R
E
R
A
V
K
R
I
V
F
S
S
S
A
T
V
Y
G
----
V
P
E
--
R
---
S
P
I
D
E
T
F
P
L
-
S
-
A
T
-
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
------------
R
DVE
A
A
D
P
-
S
--
W
--
R
V
--
A
T
L
-
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
D
P
-
A
-
G
I
P
N
N
-
L
M
P
Y
V
A
-----
Q
V
A
V
G
-----
K
L
----
E
K
L
R
-
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
E
R
------
R
D
A
----
S
-
L
------
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
R
D
-
L
-
E
R
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
81.36
42%
-94
- C1 -
1GY8
2
?
B:
[3-382]
-
M
R
V
L
V
C
G
G
A
G
Y
I
G
S
H
F
V
R
A
L
L
R
D
-
T
N
H
S
V
V
I
V
D
S
L
V
G
T
------
H
---------
G
------------
K
S
D
-----------
H
-------
V
----
E
T
R
E
N
V
A
R
K
L
Q
Q
SDGPKPPWAD
R
Y
A
A
-------
L
E
V
G
D
V
R
N
E
D
F
L
N
G
V
F
T
R
H
G
P
I
D
A
V
V
H
M
C
A
F
L
A
V
G
E
S
V
R
D
P
L
K
Y
Y
D
N
N
V
V
G
I
L
R
L
L
Q
A
M
L
L
H
K
C
D
--
K
I
I
F
S
S
S
A
A
I
F
G
----
N
P
T
--
M
TNA
E
P
I
D
I
N
A
K
K
-
S
-
P
E
-
S
P
Y
G
E
S
K
L
I
A
E
R
M
I
------------
R
---
D
C
A
E
-
A
--
Y
G
I
K
G
--
I
C
L
-
R
Y
F
N
A
C
G
A
H
E
D
G
D
I
G
E
H
Y
-
Q
-
G
-
S
T
H
-
L
I
P
I
I
L
G
R
V
M
S
D
I
A
-------------
D
K
R
M
P
I
F
G
T
D
Y
P
T
P
D
G
T
C
V
R
D
Y
V
H
V
C
D
L
A
S
A
H
I
L
A
L
D
Y
V
E
K
------
L
G
P
----
N
-
D
KSKY
F
S
V
F
N
L
G
T
S
R
G
Y
S
V
R
E
V
I
E
V
A
R
K
T
T
G
H
P
I
P
V
R
E
C
G
R
R
E
G
D
P
A
Y
L
V
A
A
S
D
K
A
R
E
V
L
G
W
K
P
K
Y
D
T
L
-
E
A
I
M
E
T
S
W
K
F
Q
R
T
H
P
N
G
Y
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
80.90
39%
-85
- C1 -
1XEL
6
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.87
39%
-87
- C1 -
1LRK
5
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
C
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
80.08
42%
-93
- C1 -
1GY8
2
?
C:
[3-382]
-
M
R
V
L
V
C
G
G
A
G
Y
I
G
S
H
F
V
R
A
L
L
R
D
-
T
N
H
S
V
V
I
V
D
S
L
V
G
T
------
H
---------
G
------------
K
S
D
-----------
H
-------
V
----
E
T
R
E
N
V
A
R
K
L
Q
Q
S
DGPKPPWAD
R
Y
A
A
-------
L
E
V
G
D
V
R
N
E
D
F
L
N
G
V
F
T
R
H
G
P
I
D
A
V
V
H
M
C
A
F
L
A
V
G
E
S
V
R
D
P
L
K
Y
Y
D
N
N
V
V
G
I
L
R
L
L
Q
A
M
L
L
H
K
C
D
--
K
I
I
F
S
S
S
A
A
I
F
G
----
N
P
T
--
M
NA-
E
P
I
D
I
N
A
K
K
-
S
-
P
E
-
S
P
Y
G
E
S
K
L
I
A
E
R
M
I
------------
R
---
D
C
A
E
-
A
--
Y
G
I
K
G
--
I
C
L
-
R
Y
F
N
A
C
G
A
H
E
D
G
D
I
G
E
H
Y
-
Q
-
G
-
S
T
H
-
L
I
P
I
I
L
G
R
V
M
S
D
I
A
P
--------DAST
D
K
R
M
P
I
F
G
T
D
Y
P
T
P
D
G
T
C
V
R
D
Y
V
H
V
C
D
L
A
S
A
H
I
L
A
L
D
Y
V
E
K
------
L
G
P
----
N
-
D
KSKY
F
S
V
F
N
L
G
T
S
R
G
Y
S
V
R
E
V
I
E
V
A
R
K
T
T
G
H
P
I
P
V
R
E
C
G
R
R
E
G
D
P
A
Y
L
V
A
A
S
D
K
A
R
E
V
L
G
W
K
P
K
Y
D
T
L
-
E
A
I
M
E
T
S
W
K
F
Q
R
T
H
P
N
G
Y
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
79.51
39%
-84
- C1 -
1KVQ
5
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
----
D
N
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
79.44
42%
-92
- C1 -
2CNB
2
?
A:
[3-382]
-
M
R
V
L
V
C
G
G
A
G
Y
I
G
S
H
F
V
R
A
L
L
R
D
-
T
N
H
S
V
V
I
V
D
S
L
V
G
T
------
H
---------
G
------------
K
S
D
-----------
H
-------
V
----
E
T
R
E
N
V
A
R
K
L
Q
Q
SDGPKPPWAD
R
Y
A
A
-------
L
E
V
G
D
V
R
N
E
D
F
L
N
G
V
F
T
R
H
G
P
I
D
A
V
V
H
M
C
A
F
L
A
V
G
E
S
V
R
D
P
L
K
Y
Y
D
N
N
V
V
G
I
L
R
L
L
Q
A
M
L
L
H
K
C
D
--
K
I
I
F
S
S
S
A
A
I
F
G
----
N
P
----TNA
E
P
I
D
I
N
A
K
K
-
S
-
P
E
-
S
P
Y
G
E
S
K
L
I
A
E
R
M
I
------------
R
---
D
C
A
E
-
A
--
Y
G
I
K
G
--
I
C
L
-
R
Y
F
N
A
C
G
A
H
E
D
G
D
I
G
E
H
Y
-
Q
-
G
-
S
T
H
-
L
I
P
I
I
L
G
R
V
M
S
D
I
A
P
D
-----------
D
K
R
M
P
I
F
G
T
D
Y
P
T
P
D
G
T
C
V
R
D
Y
V
H
V
C
D
L
A
S
A
H
I
L
A
L
D
Y
V
E
K
------
L
G
P
----
N
-
D
KSKY
F
S
V
F
N
L
G
T
S
R
G
Y
S
V
R
E
V
I
E
V
A
R
K
T
T
G
H
P
I
P
V
R
E
C
G
R
R
E
G
D
P
A
Y
L
V
A
A
S
D
K
A
R
E
V
L
G
W
K
P
K
Y
D
T
L
-
E
A
I
M
E
T
S
W
K
F
Q
R
T
H
P
N
G
Y
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
78.88
39%
-88
- C1 -
1Z45
3
GAL10_YEAST
A:
[14-356]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
V
E
L
I
E
N
-
G
Y
D
-
C
V
V
A
D
N
L
S
N
S
------
T
---------
Y
------------
D
S
V
-----------
A
-------
R
----
L
-----------------------
E
V
L
T
K
H
H
I
P
F
Y
E
V
D
L
C
D
R
K
G
L
E
K
V
F
K
E
Y
-
K
I
D
S
V
I
H
F
A
G
L
K
A
V
G
E
S
T
Q
I
P
L
R
Y
Y
H
N
N
I
L
G
T
V
V
L
L
E
L
M
--
Q
Q
Y
N
V
S
K
F
V
F
S
S
S
A
T
V
Y
G
DATR
F
P
N
--
M
---
I
P
I
P
E
E
C
P
L
-
G
-
P
T
-
N
P
Y
G
H
T
K
Y
A
I
E
N
I
L
------------
N
D
L
-
Y
N
S
D
-
K
--
K
S
W
K
F
--
A
I
L
-
R
Y
F
N
P
I
G
A
H
P
S
G
L
I
G
E
D
P
L
G
-
I
-
P
N
N
-
L
L
P
Y
M
A
-----
Q
V
A
V
G
-----
R
R
----
E
K
L
Y
-
I
F
------
R
D
G
T
P
I
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
Q
Y
L
E
A
------
Y
N
E
N
E
G
L
C
-
R
------
E
W
N
L
G
S
G
K
G
S
T
V
F
E
V
Y
H
A
F
C
K
A
S
G
I
D
L
P
Y
---------
V
L
N
L
T
A
K
P
D
R
A
K
R
E
L
K
W
Q
T
E
L
Q
-
V
-
E
D
S
C
K
D
L
W
K
W
T
T
E
N
P
F
G
Y
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
78.52
39%
-84
- C1 -
1A9Z
6
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
----
D
N
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
78.31
37%
-87
- C1 -
4LIS
6
?
B:
[5-358]
--
S
V
L
V
T
G
G
T
G
Y
I
G
S
F
T
T
L
A
L
L
E
A
-
G
Y
-
K
V
V
V
A
D
N
L
Y
N
S
------
S
---------
A
------------
E
A
L
-----------
N
R
I
E
L
I
SG
K
----
K
-----------------------
A
E
-------
F
A
Q
L
D
V
T
D
E
A
A
F
D
K
V
F
E
A
H
P
D
I
D
S
V
I
H
F
A
A
L
K
A
V
G
E
S
G
E
K
P
L
D
Y
Y
H
V
N
V
Y
G
T
I
C
L
L
R
S
M
--
V
R
H
N
V
T
N
I
V
F
S
S
S
A
T
V
Y
G
DATR
F
P
D
--
M
---
I
P
I
P
E
H
C
P
L
-
G
-
P
T
-
N
P
Y
G
N
T
K
F
A
I
E
L
A
I
T
D
V
I
N
A
Q
R
N
N
A
K
K
---
A
G
N
E
-
T
--
E
A
A
K
W
N
G
A
L
L
-
R
Y
F
N
P
A
G
A
H
P
S
G
I
M
G
E
D
P
-
Q
-
G
-
V
P
Y
N
L
L
P
L
L
A
-----
Q
V
A
T
G
-----
K
R
----
E
K
L
L
-
V
F
G
D
D
Y
A
S
H
D
G
T
A
I
R
D
Y
I
H
I
L
D
L
A
D
G
H
L
K
A
L
N
Y
L
R
A
------
N
N
P
----
G
V
R
------
A
W
N
L
G
T
G
R
G
S
T
V
Y
E
M
I
R
A
F
S
K
A
V
G
R
D
L
P
Y
E
V
A
P
R
R
A
G
D
V
L
N
L
T
S
N
P
T
R
A
N
T
E
L
G
W
K
A
Q
-
R
T
L
-
E
Q
A
C
E
D
L
W
L
W
T
K
N
N
P
Q
G
Y
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
78.13
39%
-85
- C1 -
1LRL
5
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
C
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
78.05
40%
-87
- C1 -
1EK6
4
GALE_HUMAN
A:
[3-345]
-
E
K
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
-
Y
L
P
V
V
I
D
N
F
H
N
A
F
R
G
GGS
L
---------
P
E
S
L
---------
R
R
V
-----------
Q
E
L
T
G---
R
----
S
-----------------------
V
E
-------
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
-
S
F
M
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
--
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
--
Y
---
L
P
L
D
E
A
H
P
T
-
G
G
C
T
-
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
---
D
L
C
Q
-
A
D
-
K
T
W
N
A
--
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
-
Q
G
I
-
P
N
N
-
L
M
P
Y
V
S
-----
Q
V
A
I
G
-----
R
R
----
E
A
L
N
-
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
------
Q
C
G
----
C
-
R
------
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
-
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
77.85
39%
-83
- C1 -
1LRJ
5
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
77.83
37%
-85
- C1 -
4LIS
6
?
A:
[5-358]
--
S
V
L
V
T
G
G
T
G
Y
I
G
S
F
T
T
L
A
L
L
E
A
-
G
Y
-
K
V
V
V
A
D
N
L
Y
N
S
------
S
---------
A
------------
E
A
L
-----------
N
R
I
E
L
I
SG
K
----
K
-----------------------
A
E
-------
F
A
Q
L
D
V
T
D
E
A
A
F
D
K
V
F
E
A
H
P
D
I
D
S
V
I
H
F
A
A
L
K
A
V
G
E
S
G
E
K
P
L
D
Y
Y
H
V
N
V
Y
G
T
I
C
L
L
R
S
M
--
V
R
H
N
V
T
N
I
V
F
S
S
S
A
T
V
Y
G
DATR
F
P
D
--
M
---
I
P
I
P
E
H
C
P
L
-
G
-
P
T
-
N
P
Y
G
N
T
K
F
A
I
E
L
A
I
T
D
V
I
N
A
Q
R
N
N
A
K
K
---
A
G
N
E
-
T
--
E
A
A
K
W
N
G
A
L
L
-
R
Y
F
N
P
A
G
A
H
P
S
G
I
M
G
E
D
P
-
Q
-
G
-
V
P
Y
N
L
L
P
L
L
A
-----
Q
V
A
T
G
-----
K
R
----
E
K
L
L
-
V
F
G
D
D
Y
A
S
H
D
G
T
A
I
R
D
Y
I
H
I
L
D
L
A
D
G
H
L
K
A
L
N
Y
L
R
A
------
N
N
P
----
G
V
R
------
A
W
N
L
G
T
G
R
G
S
T
V
Y
E
M
I
R
A
F
S
K
A
V
G
R
D
L
P
Y
E
V
A
P
R
R
A
G
D
V
L
N
L
T
S
N
P
T
R
A
N
T
E
L
G
W
K
A
Q
-
R
T
L
-
E
Q
A
C
E
D
L
W
L
W
T
K
N
N
P
Q
G
Y
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
77.79
39%
-85
- C1 -
1KVT
4
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
V
A
T
V
Y
G
----
D
N
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
77.72
39%
-83
- C1 -
1UDA
7
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.49
39%
-83
- C1 -
1KVR
8
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
----
D
Q
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
77.14
39%
-84
- C1 -
1UDB
7
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
76.67
39%
-82
- C1 -
1NAH
5
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
76.58
37%
-84
- C1 -
4LIS
6
?
C:
[5-358]
--
S
V
L
V
T
G
G
T
G
Y
I
G
S
F
T
T
L
A
L
L
E
A
-
G
Y
-
K
V
V
V
A
D
N
L
Y
N
S
------
S
---------
A
------------
E
A
L
-----------
N
RIELISG
K
----
K
-----------------------
A
E
-------
F
A
Q
L
D
V
T
D
E
A
A
F
D
K
V
F
E
A
H
P
D
I
D
S
V
I
H
F
A
A
L
K
A
V
G
E
S
G
E
K
P
L
D
Y
Y
H
V
N
V
Y
G
T
I
C
L
L
R
S
M
--
V
R
H
N
V
T
N
I
V
F
S
S
S
A
T
V
Y
G
DATR
F
P
D
--
M
---
I
P
I
P
E
H
C
P
L
-
G
-
P
T
-
N
P
Y
G
N
T
K
F
A
I
E
L
A
I
TDVINAQRNNAK
K
---
A
G
N
E
-
T
--
E
A
A
K
W
NG
A
L
L
-
R
Y
F
N
P
A
G
A
H
P
S
G
I
M
G
E
D
P
-
Q
-
G
-
V
P
Y
N
L
L
P
L
L
A
-----
Q
V
A
T
G
-----
K
R
----
E
K
L
L
-
V
F
G
D
D
Y
A
S
H
D
G
T
A
I
R
D
Y
I
H
I
L
D
L
A
D
G
H
L
K
A
L
N
Y
L
R
A
------
N
N
P
----
G
V
R
------
A
W
N
L
G
T
G
R
G
S
T
V
Y
E
M
I
R
A
F
S
K
A
V
G
R
D
L
P
Y
E
V
A
P
R
R
A
G
D
V
L
N
L
T
S
N
P
T
R
A
N
T
E
L
G
W
K
A
Q
-
R
T
L
-
E
Q
A
C
E
D
L
W
L
W
T
K
N
N
P
Q
G
Y
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
76.55
39%
-84
- C1 -
1UDC
9
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
Q
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
76.54
38%
-91
- C1 -
1EK5
1
GALE_HUMAN
A:
[5-344]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
-
V
I
D
N
F
H
N
A
------
F
---------
R
G
GGSLP
E
S
L
R
R
V
Q
E
L
-----------
T
-------
G
----
R
-----------------------
S
V
E
------
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
S
F
M
-
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
--
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
--
Y
---
L
P
L
D
E
A
H
P
T
-
G
-
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D
L
C
Q
A
D
K
-
T
--
W
N
A
----
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
V
S
-----
Q
V
A
I
G
-----
R
R
----
E
A
L
N
-
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
------
Q
C
G
----
C
-
R
------
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
-
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.53
39%
-85
- C1 -
1KVS
5
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
T
A
T
V
Y
G
----
D
N
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
76.30
39%
-85
- C1 -
2UDP
2
GALE_ECOLI
B:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
PVIERLG----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
Q
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
76.27
39%
-84
- C1 -
2UDP
4
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
Q
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
76.17
39%
-83
- C1 -
1A9Y
5
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
A
A
T
V
Y
G
----
D
Q
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.93
45%
-77
- C1 -
4WOK
2
?
A:
[14-326]
---
V
L
V
V
G
G
A
G
F
I
G
S
H
T
A
K
L
L
A
G
Q
-
G
Y
A
P
V
-
V
Y
D
N
L
S
T
G
------
H
---------
Q
------------
S
A
V
-----------
R
W------
G
----
D
--------------------------------
F
V
E
G
D
I
L
D
Q
A
R
L
V
E
T
M
E
K
Y
A
P
V
-
A
V
I
H
F
A
A
S
A
Y
V
G
E
S
V
E
D
P
A
K
Y
Y
R
N
N
V
G
G
T
Q
S
L
L
D
A
C
--
R
L
T
R
T
Q
N
V
I
F
S
S
S
C
A
T
Y
G
----
V
P
S
--
R
---
L
P
I
G
E
G
E
A
Q
-
N
-
P
I
-
N
P
Y
G
R
T
K
L
I
A
E
H
M
L
------------
A
---
D
Y
A
V
-
A
--
Y
G
L
R
Y
--
V
A
L
-
R
Y
F
N
A
S
G
A
D
I
D
G
E
L
G
E
K
H
-
D
-
P
-
E
T
H
-
L
I
P
R
A
M
-----
M
A
A
A
G
-----
R
L
----
D
V
L
E
-
V
Y
G
D
D
Y
E
T
P
D
G
T
C
I
R
D
Y
I
H
V
T
D
L
A
R
A
H
V
L
A
V
E
H
L
K
E
------
A
G
G
----
N
-
L
------
A
V
N
L
G
T
G
R
G
T
S
I
R
E
I
V
Q
S
I
G
R
L
T
G
R
S
V
P
V
A
M
R
A
R
R
A
G
D
P
P
A
L
Y
A
D
P
A
L
A
A
E
K
L
G
F
H
T
V
Y
S
D
L
-
D
T
I
I
R
T
A
A
P
H
F
G
L
E
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
74.98
39%
-82
- C1 -
1KVU
7
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
Q
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
74.48
39%
-83
- C1 -
1NAI
5
GALE_ECOLI
A:
[1-338]
-
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
-
G
H
D
-
V
I
I
L
D
N
L
C
N
S
------
K
---------
R
------------
S
V
L
P
V
I
E
R
L
G
----
G
-------
K
----
H
-----------------------
P
T
-------
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
H
D
H
A
-
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
--
R
A
A
N
V
K
N
F
I
F
S
S
S
A
T
V
Y
G
----
D
N
P
--
K
---
I
P
Y
V
E
S
F
P
T
G
T
-
P
Q
-
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
------------
T
---
D
L
Q
K
-
A
--
Q
P
D
W
S
--
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
I
A
-----
Q
V
A
V
G
-----
R
R
----
D
S
L
A
-
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
A
N
------
K
P
G
----
V
-
H
------
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
-
R
T
L
-
D
E
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
P
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
73.77
38%
-86
- C1 -
1I3L
6
GALE_HUMAN
B:
[5-344]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
-
V
I
D
N
F
H
N
A
------
F
---------
R
GGGSLPESLRRV
Q
E
L
-----------
T
-------
G
----
R
-----------------------
S
V
E------
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
S
F
M
-
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
--
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
--
Y
---
L
P
L
D
E
A
H
P
T
-
G
-
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
DLC
Q
A
D
K
-
T
--
W
N
V
----
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
V
S
-----
Q
V
A
I
G
-----
R
R
----
E
A
L
N
-
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
------
Q
C
G
----
C
-
R
------
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
-
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
73.41
38%
-84
- C1 -
1I3M
4
GALE_HUMAN
A:
[5-344]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
-
V
I
D
N
F
H
N
A
------
F
---------
R
G
GGSLP
E
S
L
R
R
V
Q
E
L
-----------
T
-------
G
----
R
-----------------------
S
V
E
------
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
S
F
M
-
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
--
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
--
Y
---
L
P
L
D
E
A
H
P
T
-
G
-
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D
L
C
Q
A
D
K
-
T
--
W
N
V
----
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
V
S
-----
Q
V
A
I
G
-----
R
R
----
E
A
L
N
-
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
------
Q
C
G
----
C
-
R
------
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
-
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.34
45%
-77
- C1 -
4TWR
2
?
A:
[14-326]
---
V
L
V
V
G
G
A
G
F
I
G
S
H
T
A
K
L
L
A
G
Q
-
G
Y
A
P
V
-
V
Y
D
N
L
S
T
G
------
H
---------
Q
------------
S
A
V
-----------
R
W------
G
----
D
--------------------------------
F
V
E
G
D
I
L
D
Q
A
R
L
V
E
T
M
E
K
Y
A
P
V
-
A
V
I
H
F
A
A
S
A
Y
V
G
E
S
V
E
D
P
A
K
Y
Y
R
N
N
V
G
G
T
Q
S
L
L
D
A
C
--
R
L
T
R
T
Q
N
V
I
F
S
S
S
C
A
T
Y
G
----
V
P
S
--
R
---
L
P
I
G
E
G
E
A
Q
-
N
-
P
I
-
N
P
Y
G
R
T
K
L
I
A
E
H
M
L
------------
A
---
D
Y
A
V
-
A
--
Y
G
L
R
Y
--
V
A
L
-
R
Y
F
N
A
S
G
A
D
I
D
G
E
L
G
E
K
H
-
D
-
P
-
E
T
H
-
L
I
P
R
A
M
-----
M
A
A
A
G
-----
R
L
----
D
V
L
E
-
V
Y
G
D
D
Y
E
T
P
D
G
T
C
I
R
D
Y
I
H
V
T
D
L
A
R
A
H
V
L
A
V
E
H
L
K
E
------
A
G
G
----
N
-
L
------
A
V
N
L
G
T
G
R
G
T
S
I
R
E
I
V
Q
S
I
G
R
L
T
G
R
S
V
P
V
A
M
R
A
R
R
A
G
D
P
P
A
L
Y
A
D
P
A
L
A
A
E
K
L
G
F
H
T
V
Y
S
D
L
-
D
T
I
I
R
T
A
A
P
H
F
G
L
E
V
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
73.12
38%
-83
- C1 -
1HZJ
4
GALE_HUMAN
A:
[5-344]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
-
V
I
D
N
F
H
N
A
------
F
---------
R
GGGSLP
E
S
L
R
R
V
Q
E
L
-----------
T
-------
G
----
R
-----------------------
S
V
E
------
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
S
F
M
-
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
--
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
--
Y
---
L
P
L
D
E
A
H
P
T
-
G
-
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D
L
C
Q
A
D
K
-
T
--
W
N
V
----
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
V
S
-----
Q
V
A
I
G
-----
R
R
----
E
A
L
N
-
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
------
Q
C
G
----
C
-
R
------
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
-
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
73.04
38%
-83
- C1 -
1HZJ
3
GALE_HUMAN
B:
[5-344]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
-
V
I
D
N
F
H
N
A
------
F
---------
R
GGGSLPESLRRV
Q
E
L
-----------
T
-------
G
----
R
-----------------------
S
V
E------
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
S
F
M
-
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
--
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
--
Y
---
L
P
L
D
E
A
H
P
T
-
G
-
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
DLC
Q
A
D
K
-
T
--
W
N
V
----
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
V
S
-----
Q
V
A
I
G
-----
R
R
----
E
A
L
N
-
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
------
Q
C
G
----
C
-
R
------
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
-
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
72.97
38%
-85
- C1 -
1I3K
7
GALE_HUMAN
B:
[5-344]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
-
V
I
D
N
F
H
N
A
------
F
---------
R
GGGSLPESLRRV
Q
E
L
-----------
T
-------
G
----
R
-----------------------
S
V
E------
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
S
F
M
-
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
--
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
--
Y
---
L
P
L
D
E
A
H
P
T
-
G
-
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
DLC
Q
A
D
K
-
T
--
W
N
V
----
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
V
S
-----
Q
V
A
I
G
-----
R
R
----
E
A
L
N
-
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
------
Q
C
G
----
C
-
R
------
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
-
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
71.83
38%
-84
- C1 -
1I3K
5
GALE_HUMAN
A:
[5-344]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
-
V
I
D
N
F
H
N
A
------
F
---------
R
G
GGSLP
E
S
L
R
R
V
Q
E
L
-----------
T
-------
G
----
R
-----------------------
S
V
E
------
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
S
F
M
-
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
--
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
--
Y
---
L
P
L
D
E
A
H
P
T
-
G
-
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D
L
C
Q
A
D
K
-
T
--
W
N
V
----
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
V
S
-----
Q
V
A
I
G
-----
R
R
----
E
A
L
N
-
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
------
Q
C
G
----
C
-
R
------
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
-
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
71.61
38%
-84
- C1 -
1I3L
5
GALE_HUMAN
A:
[5-344]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
-
V
I
D
N
F
H
N
A
------
F
---------
R
G
GGSLP
E
S
L
R
R
V
Q
E
L
-----------
T
-------
G
----
R
-----------------------
S
V
E
------
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
S
F
M
-
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
--
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
--
Y
---
L
P
L
D
E
A
H
P
T
-
G
-
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D
L
C
Q
A
D
K
-
T
--
W
N
V
----
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
V
S
-----
Q
V
A
I
G
-----
R
R
----
E
A
L
N
-
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
------
Q
C
G
----
C
-
R
------
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
-
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
71.57
38%
-85
- C1 -
1EK6
4
GALE_HUMAN
A:
[5-344]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
-
V
I
D
N
F
H
N
A
------
F
---------
R
G
GGSLP
E
S
L
R
R
V
Q
E
L
-----------
T
-------
G
----
R
-----------------------
S
V
E
------
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
S
F
M
-
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
--
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
--
Y
---
L
P
L
D
E
A
H
P
T
-
G
-
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D
L
C
Q
A
D
K
-
T
--
W
N
A
----
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
V
S
-----
Q
V
A
I
G
-----
R
R
----
E
A
L
N
-
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
------
Q
C
G
----
C
-
R
------
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
-
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
71.53
38%
-83
- C1 -
1I3N
6
GALE_HUMAN
A:
[5-344]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
-
V
I
D
N
F
H
N
A
------
F
---------
R
G
GGSLP
E
S
L
R
R
V
Q
E
L
-----------
T
-------
G
----
R
-----------------------
S
V
E
------
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
S
F
M
-
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
--
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
--
Y
---
L
P
L
D
E
A
H
P
T
-
G
-
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D
L
C
Q
A
D
K
-
T
--
W
N
V
----
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
V
S
-----
Q
V
A
I
G
-----
R
R
----
E
A
L
N
-
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
------
Q
C
G
----
C
-
R
------
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
-
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
71.20
38%
-82
- C1 -
1I3M
5
GALE_HUMAN
B:
[5-344]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
-
V
I
D
N
F
H
N
A
------
F
---------
R
GGGSLPESLRRV
Q
E
L
-----------
T
-------
G
----
R
-----------------------
S
V
E------
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
S
F
M
-
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
--
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
--
Y
---
L
P
L
D
E
A
H
P
T
-
G
-
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
DLC
Q
A
D
K
-
T
--
W
N
V
----
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
V
S
-----
Q
V
A
I
G
-----
R
R
----
E
A
L
N
-
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
------
Q
C
G
----
C
-
R
------
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
-
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
71.20
38%
-83
- C1 -
1I3N
4
GALE_HUMAN
B:
[5-344]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
-
V
I
D
N
F
H
N
A
------
F
---------
R
GGGSLPESLRRV
Q
E
L
-----------
T
-------
G
----
R
-----------------------
S
V
E------
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
S
F
M
-
A
V
I
H
F
A
G
L
K
A
M
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
--
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
--
Y
---
L
P
L
D
E
A
H
P
T
-
G
-
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
DLC
Q
A
D
K
-
T
--
W
N
V
----
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
V
S
-----
Q
V
A
I
G
-----
R
R
----
E
A
L
N
-
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
------
Q
C
G
----
C
-
R
------
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
-
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
70.43
38%
-80
- C1 -
1EK6
3
GALE_HUMAN
B:
[5-344]
---
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
L
E
L
L
E
A
-
G
Y
L
P
V
-
V
I
D
N
F
H
N
A
------
F
---------
R
G
GGSLP
E
S
L
R
R
V
Q
E
L
-----------
T
-------
G
----
R
-----------------------
S
V
E
------
F
E
E
M
D
I
L
D
Q
G
A
L
Q
R
L
F
K
K
Y
S
F
M
-
A
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
D
Y
Y
R
V
N
L
T
G
T
I
Q
L
L
E
I
M
--
K
A
H
G
V
K
N
L
V
F
S
S
S
A
T
V
Y
G
----
N
P
Q
--
Y
---
L
P
L
D
E
A
H
P
T
-
G
-
G
C
T
N
P
Y
G
K
S
K
F
F
I
E
E
M
I
------------
R
D
L
C
Q
A
D
K
-
T
--
W
N
A
----
V
L
L
-
R
Y
F
N
P
T
G
A
H
A
S
G
C
I
G
E
D
P
-
Q
-
G
I
P
N
N
-
L
M
P
Y
V
S
-----
Q
V
A
I
G
-----
R
R
----
E
A
L
N
-
V
F
G
N
D
Y
D
T
E
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
K
G
H
I
A
A
L
R
K
L
K
E
------
Q
C
G
----
C
-
R
------
I
Y
N
L
G
T
G
T
G
Y
S
V
L
Q
M
V
Q
A
M
E
K
A
S
G
K
K
I
P
Y
K
V
V
A
R
R
E
G
D
V
A
A
C
Y
A
N
P
S
L
A
Q
E
E
L
G
W
T
A
A
L
-
G
L
-
D
R
M
C
E
D
L
W
R
W
Q
K
Q
N
P
S
G
F
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------