@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1947: (2015-12-12 )
MTKKIFRTTLSASLGIVLVTILMIMGFLYNYFNHIQREQLRTQTALASQGISFEGKDYFENLKTSNVRITWVDNKGQVLYDTQSDAKHMKNHANRQEIKEAIKSGYGESTRWSATLTEKSIYAAQRLNNGTIVRLSVAQQTIFYLLLGMISPLAIIILLAIILSVLIARYIAKKVSEPLNNIDLDHPLSNDSYEEITPLLRRLDSHQAKIQHQKLLLQKRQKEFDTIISKIKEGMILLDDQARIVSINAEALKLFQINDDWHGRFMMEVSRDLTLKDLIDQGLKGKKKEANIGIENNHYRVLVRPTTDNNRVTGLVVLLFDVTDQLQMEQLQREFTANVSHELKTPLHVISGYSELLANQMVPNEEVPQFAAKIHKESERLVKLVEDIISLSHLDEQEKLPQETVNLYDLTQKVLEGLQAKADKKHIQINFNGEEAILRGNPVLLNSLVYNLCDNAITYNHEKGQVNVTLKNSPDTITLEVSDTGLGIAEKDKKRIFERFYRVDKSRSKIVGGTGLGLSIVKSALDFHNGSIKVDSHLGQGTTMTVLLHKQ
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180....---------------...190.......200..--.....210.......220.......230.......240.......250.......260........270.......280----.........-290........300......----..--310----........320.......330----..---------.------......340.......350.......360-.-----.....-..370.......380.......390....-..-.-400..-------......410.......420-----....--..-----...430-.--..--.-----.--....440----------.......450.......460.-------.---.---.--...470--.......480.......490.......500....------...510.......520....-...530..-.....540.......550
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
K
K
I
F
R
T
T
L
S
A
S
L
G
I
V
L
V
T
I
L
M
I
M
G
F
L
Y
N
Y
F
N
H
I
Q
R
E
Q
L
R
T
Q
T
A
LASQGISFE
G
K
D
Y
F
E
NLKTS
N
V
R
I
T
W
VDNK
G
Q
V
L
Y
DTQS
D
A
K
H
M
K
N
HA
N
R
Q
E
I
K
E
A
I
K
SGYGEST
R
W
S
A
T
LTEK
S
I
Y
A
A
Q
RLNN
G
T
I
V
R
L
S
V
A
Q
Q
T
I
F
Y
L
L
L
G
M
I
S
P
L
A
I
I
I
L
L
A
I
I
L
S
V
L
I
A
R
Y
I
A
K
K
V
SEPLNNIDLDH---------------PLSND
S
Y
E
E
I
T
P
L
L
R
R
L
D
--
S
H
Q
A
K
I
Q
H
Q
K
L
L
L
Q
K
R
Q
K
E
F
D
T
I
I
S
K
I
KE
G
M
I
L
LDDQ
A
R
I
V
S
INA
E
A
L
K
L
F
Q
INDD-WH
G
R
F
M
M
E
VSRDL
T
L
K
D
L
I
D
------QGLKGKKKE-A-NIGIENN
H
Y
R
-
V
L
V
R
PTT----DN--N
R
-----
V
T
G
L
V
V
L
L
FDV
T
D
Q
L
Q
M
E
Q
------
L
Q
---------
R
------
E
F
TAN
V
S
H
ELKT
P
L
H
V
I
S
G
Y
S
E
L
L
A
NQM--V-----P
N
E
E
V
-
P
Q
F
A
A
K
I
H
K
E
S
E
R
L
V
K
L
V
E
D
I
I
S
L
SH
L
D
E
-
Q
E
-K-L
P
-
Q
E
-------
T
V
N
L
Y
D
L
T
Q
K
V
L
E
G
L
Q
A-------KADK--
K
H
-----
I
Q
I
N
---F--NG--
E
-----
E
--
A
I
LRGN
P
----------
V
L
L
N
S
L
V
Y
N
LCDN
A
I
T
YNHEK-------
G
---
Q
---
V
--
N
V
T
LKN--SP
D
T
I
T
L
E
VSDTGLGI
A
E
K
D
K
K
R
I
F
E
R
F
Y
R
VDKS------RSKIVGGTG
L
G
L
S
I
V
K
S
A
L
D-FHNG
S
I
K
V
-
D
SHLGQG
T
T
M
T
V
L
L
HKQ
14
PsiBlast_PDB
84.93
31%
-80
- C3 -
4JAV
6
?
A:
[3-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
T
E
S
K
E
L
E
R
------
L
K
---------
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
GE
L
-----
D
L
S
T
L
-
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
-
K
S
L
Q
-
I
N
-
R
E
-------
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
-------
F
A
S
S
--
H
N
-----
V
N
V
L
---
F
--
E
S
--
N
VPCPV
E
--
A
Y
I
--
D
P
----------
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
-------
A
---
P
D
K
Y
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
------
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
-
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
36
PsiBlast_CBE
81.66
31%
-81
- C3 -
4JAV
6
?
B:
[5-247]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
S
K
E
L
E
R
------
L
K
---------
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
GE
L
-----
D
L
S
T
L
-
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
-
K
S
L
Q
-
I
N
-
R
E
-------
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
-------
F
A
S
S
--
H
N
-----
V
N
V
L
---
F
--
E
S
--
N
VPCPV
E
--
A
Y
I
--
D
P
----------
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
-------
A
---
P
D
K
Y
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
------
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
-
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
15
PsiBlast_PDB
80.98
31%
-85
- C3 -
2C2A
2
?
A:
[3-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
T
E
S
K
E
L
E
R
------
L
K
---------
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
GE
L
-----
D
L
S
T
L
-
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
-
K
S
L
Q
-
I
N
-
R
E
-------
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
-------
F
A
S
S
--
H
N
-----
V
N
V
L
---
F
--
E
S
--
N
VPCPV
E
--
A
Y
I
--
D
P
----------
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
-------
A
---
P
D
K
Y
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
-
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
1
PsiBlast_PDB
79.27
32%
-74
- C3 -
4U7N
-
?
A:
[39-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
--
W
-----
K
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
-
R
-
V
D
-
M
E
-------
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
DDN---
Y
--
Y
T
-----
I
K
R
E
---
F
--
T
K
--
R
-----
D
--
L
W
V
E
I
D
T
----------
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
-------
G
---
V
---
V
--
T
C
R
L
L
E
--
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
-----------------
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
-
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
21
PsiBlast_CBE
79.00
32%
-63
- C3 -
4U7O
1
?
B:
[37-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
--
W
-----
K
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
------
T
-
R
-
V
D
-
M
E
-------
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
DDN
P
A
K
Y
--
Y
T
-----
I
K
R
E
---
F
--
T
K
--
R
-----
D
--
L
W
V
E
I
D
T
----------
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
-------
G
---
V
---
V
--
T
C
R
L
L
E
--
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
------
R
---
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
-
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
2
PsiBlast_PDB
78.45
32%
-63
- C3 -
4U7O
1
?
A:
[25-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
------
D
R
---------
K
------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
--
W
-----
K
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
-
R
-
V
D
-
M
E
-------
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
KKDDN
P
A
K
Y
--
Y
T
-----
I
K
R
E
---
F
--
T
K
--
R
-----
D
--
L
W
V
E
I
D
T
----------
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
-------
G
---
V
---
V
--
T
C
R
L
L
E
--
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----------
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
-
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
9
PsiBlast_PDB
78.18
32%
-86
- C3 -
4JAU
1
?
A:
[7-247]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
L
E
R
------
L
K
---------
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
GE
L
-----
D
L
S
T
L
-
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
-
K
S
L
Q
-
I
N
-
R
E
-------
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
-------
F
A
S
S
--
H
N
-----
V
N
V
L
---
F
--
E
S
--
N
VPCPV
E
--
A
Y
I
--
D
P
----------
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
-------
A
---
P
D
K
Y
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
---------------
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
-
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
-
8
PsiBlast_PDB
77.91
32%
-80
- C3 -
4JAS
2
?
A:
[13-247]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
---------
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
GE
L
-----
D
L
S
T
L
-
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
-
K
S
L
Q
-
I
N
-
R
E
-------
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
-------
F
A
S
S
--
H
N
-----
V
N
V
L
---
F
--
E
S
--
N
VPCPV
E
--
A
Y
I
--
D
P
----------
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
-------
A
---
P
D
K
Y
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
------
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
-
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
13
PsiBlast_PDB
77.70
31%
-75
- C3 -
3DGE
3
?
A:
[14-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---------
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
GE
L
-----
D
L
S
T
L
-
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
-
K
S
L
Q
-
I
N
-
R
E
-------
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
-------
F
A
S
S
--
H
N
-----
V
N
V
L
---
F
--
E
S
--
N
VPCPV
E
--
A
Y
I
--
D
P
----------
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
-------
A
---
P
D
K
Y
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
------
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
-
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
38
Fugue
77.32
26%
-43
- C3 -
4I5S
-
?
A:
[37-432]
--------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
------------------------------------------------------------------------------------------------------------------------------------
H
Y
T
D
---------------
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
--
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
-
Q
A
L
E
C
N
I
L
D
I
L
D
D
D
S
Y
T
Y
N
D
------
L
I
T
K
T
P
E
I
V
-
L
-
T
R
R
D
E
Y
D
E
F
I
-
T
L
R
I
R
F
A
L
NRR
E
S
--
G
F
-----
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
------
E
R
---------
R
------
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
--
L
-----
T
E
S
V
A
-
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
-----
R
S
-
H
-
L
D
-
V
E
-------
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
-------
I
Q
S
Q
--
Q
S
TE---
I
I
R
D
---
Y
--
P
D
--
K
-----
S
--
V
W
I
E
I
D
T
----------
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
-------
G
---
K
---
V
--
T
I
T
M
Q
T
--
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
------
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
-
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
--
49
HHSearch
77.28
32%
-69
- C3 -
2C2A
2
?
A:
[2-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
T
E
S
K
E
L
E
R
L
K
R
I
D
R
M
K
---------
T
------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
--
G
EL---
D
L
S
T
L
-
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
-
K
S
-
L
-
Q
I
N
R
E
-------
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
-------
F
A
S
S
--
H
N
-----
V
N
V
L
---
F
--
E
S
--
N
VPC--
P
--
V
E
A
Y
I
D
P
----------
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
-------
A
P
D
K
Y
---
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
-
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
37
PsiBlast_CBE
76.86
31%
-70
- C3 -
3DGE
2
?
B:
[14-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---------
R
IDRMKT
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
GE
L
-----
D
L
S
T
L
-
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
-
K
S
L
Q
-
I
N
-
R
E
-------
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
-------
F
A
S
S
--
H
N
-----
V
N
V
L
---
F
--
E
S
--
N
VPCPV
E
--
A
Y
I
--
D
P
----------
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
-------
A
---
P
DKY
V
--
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
------
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
-
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
48
HHSearch
76.74
23%
-82
- C3 -
3A0R
1
?
A:
[9-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
E
S
I
L
E
S
L
E
T
A
I
I
T
L
S
K
D
G
R
I
T
E
W
N
K
K
A
E
Q
L
F
G
L
K
K
E
N
V
L
G
R
R
L
K
D
L
P
D
F
E
E
I
G
S
V
A
E
------
S
V
F
E
N
K
E
P
V
F
L
N
F
Y
K
F
G
E
R
Y
F
N
-
I
R
F
S
P
F
R
----
N
A
KT
Q
L
-----
L
E
G
V
I
I
T
I
D
D
V
T
E
L
Y
K
Y
E
E
------
E
R
K
R
R
E
R
L
S
I
L
G
------
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
K
K
H
L
--
D
-----
D
P
E
T
L
-
K
K
Y
I
N
I
I
T
N
E
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
E
R
--
V
----
L
E
-
F
T
-------
E
F
N
L
N
E
L
I
R
E
V
Y
V
L
F
E
E
-------
K
I
R
K
--
M
N
-----
I
D
F
C
---
F
--
E
T
--
D
NE---
D
--
L
R
V
E
A
D
R
----------
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
G
E
N
-------
G
---
K
---
I
--
K
I
T
S
E
D
--
M
Y
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
T
T
------------------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
-
E
N
R
-
E
N
G
V
V
F
I
F
E
I
P
K
T
3
PsiBlast_PDB
75.15
28%
-50
- C3 -
4I5S
-
?
A:
[37-431]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
--
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
--
Q
L
N
-------
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
DDSY
T
Y
N
D
L
I
T
K
T
P
E
-
I
-
V
L
T
R
R
D
E
Y
D
E
F
I
T
L
R
I
R
F
----
A
L
--
N
R
RESGF
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
------
E
R
---------
R
------
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
--
L
-----
T
E
S
V
A
-
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-------
S
H
L
D
-
V
E
-------
L
T
N
F
T
A
F
M
N
Y
I
L
D
-----------
R
F
D
Q
--
I
Q
-----
S
Q
Q
S
---
T
---------------
E
I
I
R
D
Y
P
D
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
-------
G
---
K
---
V
--
T
I
T
M
Q
T
--
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
------
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
-
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
--
23
PsiBlast_CBE
69.04
33%
-47
- C3 -
4BIU
1
CPXA_ECOLI
E:
[70-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
------
S
Q
---------
Q
------
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
--
G
-----
E
S
K
E
L
-----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
-
K
N
-
A
-
L
V
-
S
E
-------
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
-------
E
A
E
Q
MG
K
S
-----
L
T
V
N
---
F
--
P
P
--
G
-----
P
--
W
P
L
Y
G
N
P
----------
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
-------
I
---
E
---
V
--
G
F
A
V
D
K
----
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
-------------------
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
-
16
PsiBlast_PDB
67.96
30%
-54
- C3 -
4Q20
-
DIVL_CAUCR
A:
[35-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
E
R
------
L
K
---------
R
------
D
F
V
G
N
V
S
Y
E
L
R
T
P
L
T
T
I
I
G
Y
S
E
L
L
E
R
A
D
---------
S
E
R
G
-
R
N
H
V
A
A
V
R
A
A
A
T
Q
L
A
R
S
I
D
D
V
L
D
M
A
Q
I
D
A
-
G
E
M
A
-
L
E
-
I
E
-------
D
I
R
V
S
D
L
L
L
N
A
Q
E
R
A
L
K
-------
D
A
Q
L
--
G
G
-----
V
T
L
A
---
V
--
E
C
--
E
-----
E
DV
G
L
I
R
G
D
G
----------
K
R
L
A
Q
T
L
D
H
L
V
E
N
A
L
R
Q
T
P
P
G
-------
G
---
R
---
V
--
T
L
S
A
R
R
--
A
L
G
E
V
R
L
D
V
S
D
T
G
R
G
V
P
F
H
V
Q
A
H
I
F
D
R
F
V
G
R
D
R
------------
G
G
P
G
L
G
L
A
L
V
K
A
L
V
E
-
L
H
G
G
W
V
A
L
-
E
S
E
P
G
N
G
S
T
F
T
C
H
L
P
E
T
4
PsiBlast_PDB
63.48
33%
-48
- C3 -
4BIU
-
CPXA_ECOLI
A:
[70-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
------
S
Q
---------
Q
------
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
--
G
-----
E
S
K
E
L
-----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
-
K
N
-
A
-
L
V
-
S
E
-------
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
-------
E
A
E
Q
M
G
K
S
-----
L
T
V
N
---
F
--
P
P
--
G
-----
P
--
W
P
L
Y
G
N
P
----------
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
-------
I
---
E
---
V
--
G
F
A
V
D
K
----
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
----------------
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
22
PsiBlast_CBE
62.74
33%
-32
- C3 -
4BIU
2
CPXA_ECOLI
F:
[70-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
------
S
Q
---------
Q
------
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
--
G
-----
E
S
K
E
L
-----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
-
K
N
-
A
-
L
V
-
S
E
-------
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
-------
E
A
E
Q
MG
K
S
-----
L
T
V
N
---
F
--
P
P
--
G
-----
P
--
W
P
L
Y
G
N
P
----------
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
-------
I
---
E
---
V
--
G
F
A
V
D
K
----
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
------
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
-
6
PsiBlast_PDB
61.52
33%
-46
- C3 -
4BIX
3
CPXA_ECOLI
A:
[70-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
------
S
Q
---------
Q
------
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
--
G
-----
E
S
K
E
L
-----
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
-
K
N
-
A
-
L
V
-
S
E
-------
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
-------
E
A
E
Q
M
G
K
S
-----
L
T
V
N
---
F
--
P
P
--
G
-----
P
--
W
P
L
Y
G
N
P
----------
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
-------
I
---
E
---
V
--
G
F
A
V
D
K
----
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
52
HHSearch
61.15
19%
-60
- C3 -
2Q8G
1
PDK1_HUMAN
A:
[104-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------
A
I
---------
Y
------
D
F
T
D
T
V
I
R
I
R
N
R
H
N
D
V
I
P
T
M
A
Q
G
V
I
E
Y
K
--
E
S
FDPV
T
S
Q
N
V
-
Q
Y
F
L
D
R
F
Y
M
S
R
I
S
I
R
M
L
L
N
Q
H
S
L
L
F
G
-------------
K
HIGSINP
N
C
N
V
L
E
V
I
K
D
G
Y
E
N
A
R
R
-------
L
C
D
L
--
Y
Y
I
N
S
P
E
L
E
L
E
E
L
N
A
KS
P
G
--
Q
-----
P
--
I
Q
V
V
Y
V
P
----------
S
H
L
Y
H
M
V
F
E
L
F
K
N
A
M
R
A
T
M
E
H
H
ANRG
V
Y
P
---
P
---
I
--
Q
V
H
V
T
L
--
G
N
E
D
L
T
V
K
M
S
D
R
G
G
G
V
P
L
R
K
I
D
R
L
F
N
Y
M
Y
S
T
A
P
R
PRVETS
R
A
V
P
L
A
G
F
G
Y
G
L
P
I
S
R
L
Y
A
Q
-
Y
F
Q
G
D
L
K
L
-
Y
S
L
E
G
Y
G
T
D
A
V
I
Y
I
K
A
L
58
HHSearch
55.14
31%
-67
- C3 -
3SL2
2
A:
[3-151]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
I
V
R
F
M
S
L
I
I
D
R
F
E
M
-------
T
K
-
E
--
Q
-------
E
F
I
---
R
--
N
L
PD
R
-----
D
--
L
Y
V
E
I
D
Q
----------
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
E
G
-------
G
---
H
---
V
--
T
F
S
I
D
V
NE
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
-
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
17
PsiBlast_PDB
33.69
43%
-18
- C3 -
3SL2
2
A:
[50-149]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
I
S
N
A
L
K
Y
S
P
E
G
-------
G
---
H
---
V
T
F
S
I
D
V
N
E
--
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
-
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K