@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2047: (2015-12-12 )
MAKKTKKAEEITKKFGDERRKALDDALKNIEKDFGKGAVMRLGERAEQKVQVMSSGSLALDIALGAGGYPKGRIVEIYGPESSGKTTVALHAVAQAQKEGGIAAFIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVAALVPRAEIDGDIGDSHVGLQARMMSQAMRKLSASINKTKTIAIFINQLREKVGVMFGNPETTPGGRALKFYSSVRLDVRGNTQIKGTGEHKDHNVGKETKIKVVKNKVAPPFREAFVEIMYGEGISRTGELIKIASDLDIIQKAGAWYSYNGEKIGQGSENAKKYLADNPAIFDEIDHKVRVHFGMTEDDSPVQSELVEEKNEADDLVLDLDNAIEIEE
Atome Classification :
(39 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240...-....250.......260.......270.......280.......290.......300.......310.......320.......330.......340---........350.......360.......370.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAKK
T
K
K
A
E
E
I
T
K
K
F
G
D
E
R
R
K
A
L
D
D
A
L
K
N
I
E
K
D
FGK
G
A
V
M
R
L
G
E
R
A
E
Q
K
V
Q
V
MSSG
S
L
A
L
D
I
A
LGAGGYPKG
R
I
V
E
I
YGPESSG
K
T
T
V
A
L
H
A
V
A
Q
A
Q
KEGG
I
A
A
F
IDAEHAL
D
P
A
Y
A
A
A
LGV
N
I
D
E
L
L
LSQPDSGE
Q
G
L
E
I
A
G
K
L
IDSG
A
V
D
L
V
V
V
D
S
V
A
A
LVPRAEIDGDIGD
S
H
V
G
L
Q
A
R
M
M
S
Q
A
M
R
K
L
S
A
SINK
T
K
T
I
A
I
F
I
N
Q
L
R
E
KV
G
V
M
FGNPETTPGG
R
A
L
K
F
Y
S
S
V
R
L
D
VRGN
T
Q
I
K
-GTGEHKDHNVGK
E
T
K
I
K
V
V
KNKVA
P
P
F
R
E
A
F
V
E
I
M
YGEGISRT
G
E
L
I
K
IA
S
D
L
D
I
I
Q
KAGAWYSYNGEKIGQG
S
E
N
A
K
K
YLADNP
A
I
F
D
EID
H
K
V
R
----
V
H
FGMTEDDS
P
V
Q
S
E
L
V
E
EKNEAD
D
L
V
L
DLDNAIEIEE
65
HHSearch
97.44
62%
-86
* C3 *
3CMW
6
RECA_ECOLI
A:
[328-655]
----------------
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
G
E
D
R
S
M
D
V
E
T
I
S
T
G
S
L
S
L
D
I
A
L
G
A
G
G
L
P
M
G
R
I
V
E
I
Y
G
P
E
S
S
G
K
T
T
L
T
L
Q
V
I
A
A
A
Q
R
E
G
K
T
C
A
F
I
D
A
E
H
A
L
D
P
I
Y
A
R
K
L
G
V
D
I
D
N
L
L
C
S
Q
P
D
T
G
E
Q
A
L
E
I
C
D
A
L
A
R
S
G
A
V
D
V
I
V
V
D
S
V
A
A
L
T
P
K
A
E
I
E
G
E
I
G
D
S
H
M
G
L
A
A
R
M
M
S
Q
A
M
R
K
L
A
G
N
L
K
Q
S
N
T
L
L
I
F
I
N
Q
I
R
M
K
I
G
V
M
F
G
N
P
E
T
T
T
G
G
N
A
L
K
F
Y
A
S
V
R
L
D
I
R
R
I
G
A
V
K
-
E
G
E
----
N
V
V
G
S
E
T
R
V
K
V
V
K
N
K
I
A
A
P
F
K
Q
A
E
F
Q
I
L
Y
G
E
G
I
N
F
Y
G
E
L
V
D
L
G
V
K
E
K
L
I
E
K
A
G
A
W
Y
S
Y
K
G
E
K
I
G
Q
G
K
A
N
A
T
A
W
L
K
D
N
P
E
T
A
K
E
I
E
K
K
V
R
----
E
L
L
L
S
N
P
N
S
A
I
D
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
62
HHSearch
97.29
62%
-85
- C3 -
3CMW
6
RECA_ECOLI
A:
[329-656]
-----------------
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
G
E
D
R
S
M
D
V
E
T
I
S
T
G
S
L
S
L
D
I
A
L
G
A
G
G
L
P
M
G
R
I
V
E
I
Y
G
P
E
S
S
G
K
T
T
L
T
L
Q
V
I
A
A
A
Q
R
E
G
K
T
C
A
F
I
D
A
E
H
A
L
D
P
I
Y
A
R
K
L
G
V
D
I
D
N
L
L
C
S
Q
P
D
T
G
E
Q
A
L
E
I
C
D
A
L
A
R
S
G
A
V
D
V
I
V
V
D
S
V
A
A
L
T
P
K
A
E
I
E
G
E
I
G
D
S
H
M
G
L
A
A
R
M
M
S
Q
A
M
R
K
L
A
G
N
L
K
Q
S
N
T
L
L
I
F
I
N
Q
I
R
M
K
I
G
V
M
F
G
N
P
E
T
T
T
G
G
N
A
L
K
F
Y
A
S
V
R
L
D
I
R
R
I
G
A
V
K
-
E
G
E
----
N
V
V
G
S
E
T
R
V
K
V
V
K
N
K
I
A
A
P
F
K
Q
A
E
F
Q
I
L
Y
G
E
G
I
N
F
Y
G
E
L
V
D
L
G
V
K
E
K
L
I
E
K
A
G
A
W
Y
S
Y
K
G
E
K
I
G
Q
G
K
A
N
A
T
A
W
L
K
D
N
P
E
T
A
K
E
I
E
K
K
V
R
----
E
L
L
L
S
N
P
N
S
A
I
D
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
2
PsiBlast_PDB
95.54
61%
-87
- C3 -
4PR0
5
RECA_MYCTU
A:
[6-330]
-----------------
D
R
E
K
A
L
E
L
A
V
A
Q
I
E
K
S
Y
G
K
G
S
V
M
R
L
G
D
E
A
R
Q
P
I
S
V
I
P
T
G
S
I
A
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
V
A
A
F
I
D
A
E
H
A
L
D
P
D
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
I
R
S
G
A
L
D
I
V
V
I
D
S
V
A
A
L
V
P
R
A
E
L
E
G
E
M
G
D
S
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
R
-------------
T
G
G
K
A
L
K
F
Y
A
S
V
R
M
D
V
R
R
V
E
T
L
K
D
G
T
-----
N
A
V
G
N
R
T
R
V
K
V
V
K
N
K
C
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
K
G
I
S
R
E
G
S
L
I
D
M
G
V
D
Q
G
L
I
R
K
S
G
A
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
N
F
L
V
E
N
A
D
V
A
D
E
I
E
K
K
I
K
----
E
K
L
G
I
---------------------------------
41
PsiBlast_CBE
95.32
62%
-87
- C3 -
3CMW
6
RECA_ECOLI
A:
[328-648]
----------------
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
G
E
D
R
S
M
D
V
E
T
I
S
T
G
S
L
S
L
D
I
A
L
G
A
G
G
L
P
M
G
R
I
V
E
I
Y
G
P
E
S
S
G
K
T
T
L
T
L
Q
V
I
A
A
A
Q
R
E
G
K
T
C
A
F
I
D
A
E
H
A
L
D
P
I
Y
A
R
K
L
G
V
D
I
D
N
L
L
C
S
Q
P
D
T
G
E
Q
A
L
E
I
C
D
A
L
A
R
S
G
A
V
D
V
I
V
V
D
S
V
A
A
L
T
P
K
A
E
I
E
G
E
I
G
D
S
H
M
G
L
A
A
R
M
M
S
Q
A
M
R
K
L
A
G
N
L
K
Q
S
N
T
L
L
I
F
I
N
Q
I
R
M
K
I
G
V
M
F
G
N
P
E
T
T
T
G
G
N
A
L
K
F
Y
A
S
V
R
L
D
I
R
R
I
G
A
V
K
-----
E
G
E
N
V
V
G
S
E
T
R
V
K
V
V
K
N
K
I
A
A
P
F
K
Q
A
E
F
Q
I
L
Y
G
E
G
I
N
F
Y
G
E
L
V
D
L
G
V
K
E
K
L
I
E
K
A
G
A
W
Y
S
Y
K
G
E
K
I
G
Q
G
K
A
N
A
T
A
W
L
K
D
N
P
E
T
A
K
E
I
E
K
K
V
R
----
E
L
L
L
S
N
P
N
S
A
I
D
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
42
PsiBlast_CBE
94.98
62%
-86
- C3 -
3CMT
7
RECA_ECOLI
D:
[328-648]
----------------
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
G
E
D
R
S
M
D
V
E
T
I
S
T
G
S
L
S
L
D
I
A
L
G
A
G
G
L
P
M
G
R
I
V
E
I
Y
G
P
E
S
S
G
K
T
T
L
T
L
Q
V
I
A
A
A
Q
R
E
G
K
T
C
A
F
I
D
A
E
H
A
L
D
P
I
Y
A
R
K
L
G
V
D
I
D
N
L
L
C
S
Q
P
D
T
G
E
Q
A
L
E
I
C
D
A
L
A
R
S
G
A
V
D
V
I
V
V
D
S
V
A
A
L
T
P
K
A
E
I
E
G
E
I
G
D
S
H
M
G
L
A
A
R
M
M
S
Q
A
M
R
K
L
A
G
N
L
K
Q
S
N
T
L
L
I
F
I
N
Q
I
R
M
K
I
G
V
M
F
G
N
P
E
T
T
T
G
G
N
A
L
K
F
Y
A
S
V
R
L
D
I
R
R
I
G
A
V
K
-----
E
G
E
N
V
V
G
S
E
T
R
V
K
V
V
K
N
K
I
A
A
P
F
K
Q
A
E
F
Q
I
L
Y
G
E
G
I
N
F
Y
G
E
L
V
D
L
G
V
K
E
K
L
I
E
K
A
G
A
W
Y
S
Y
K
G
E
K
I
G
Q
G
K
A
N
A
T
A
W
L
K
D
N
P
E
T
A
K
E
I
E
K
K
V
R
----
E
L
L
L
S
N
P
N
S
A
I
D
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
40
PsiBlast_CBE
94.93
62%
-87
- C3 -
3CMW
7
RECA_ECOLI
C:
[328-648]
----------------
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
G
E
D
R
S
M
D
V
E
T
I
S
T
G
S
L
S
L
D
I
A
L
G
A
G
G
L
P
M
G
R
I
V
E
I
Y
G
P
E
S
S
G
K
T
T
L
T
L
Q
V
I
A
A
A
Q
R
E
G
K
T
C
A
F
I
D
A
E
H
A
L
D
P
I
Y
A
R
K
L
G
V
D
I
D
N
L
L
C
S
Q
P
D
T
G
E
Q
A
L
E
I
C
D
A
L
A
R
S
G
A
V
D
V
I
V
V
D
S
V
A
A
L
T
P
K
A
E
I
E
G
E
I
G
D
S
H
M
G
L
A
A
R
M
M
S
Q
A
M
R
K
L
A
G
N
L
K
Q
S
N
T
L
L
I
F
I
N
Q
I
R
M
K
I
G
V
M
F
G
N
P
E
T
T
T
G
G
N
A
L
K
F
Y
A
S
V
R
L
D
I
R
R
I
G
A
V
K
-----
E
G
E
N
V
V
G
S
E
T
R
V
K
V
V
K
N
K
I
A
A
P
F
K
Q
A
E
F
Q
I
L
Y
G
E
G
I
N
F
Y
G
E
L
V
D
L
G
V
K
E
K
L
I
E
K
A
G
A
W
Y
S
Y
K
G
E
K
I
G
Q
G
K
A
N
A
T
A
W
L
K
D
N
P
E
T
A
K
E
I
E
K
K
V
R
----
E
L
L
L
S
N
P
N
S
A
I
D
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
1
PsiBlast_PDB
94.89
61%
-91
- C3 -
4PQY
1
RECA_MYCTU
A:
[6-330]
-----------------
D
R
E
K
A
L
E
L
A
V
A
Q
I
E
K
S
Y
G
K
G
S
V
M
R
L
G
D
E
A
R
Q
P
I
S
V
I
P
T
G
S
I
A
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
V
A
A
F
I
D
A
E
H
A
L
D
P
D
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
I
R
S
G
A
L
D
I
V
V
I
D
S
V
A
A
L
V
P
R
A
E
L
E
G
E
M
G
D
S
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
R
------------
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
M
D
V
R
R
V
E
T
L
K
D
G
T
-----
N
A
V
G
N
R
T
R
V
K
V
V
K
N
K
C
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
K
G
I
S
R
E
G
S
L
I
D
M
G
V
D
Q
G
L
I
R
K
S
G
A
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
N
F
L
V
E
N
A
D
V
A
D
E
I
E
K
K
I
K
----
E
K
L
G
I
G
--------------------------------
67
HHSearch
94.81
63%
-88
- C3 -
3CMU
7
RECA_ECOLI
A:
[331-654]
-------------------
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
G
E
D
R
S
M
D
V
E
T
I
S
T
G
S
L
S
L
D
I
A
L
G
A
G
G
L
P
M
G
R
I
V
E
I
Y
G
P
E
S
S
G
K
T
T
L
T
L
Q
V
I
A
A
A
Q
R
E
G
K
T
C
A
F
I
D
A
E
H
A
L
D
P
I
Y
A
R
K
L
G
V
D
I
D
N
L
L
C
S
Q
P
D
T
G
E
Q
A
L
E
I
C
D
A
L
A
R
S
G
A
V
D
V
I
V
V
D
S
V
A
A
L
T
P
K
A
E
I
E
G
E
I
G
D
S
H
M
G
L
A
A
R
M
M
S
Q
A
M
R
K
L
A
G
N
L
K
Q
S
N
T
L
L
I
F
I
N
Q
I
R
M
K
I
G
V
M
F
G
N
P
E
T
T
T
G
G
N
A
L
K
F
Y
A
S
V
R
L
D
I
R
R
I
G
A
V
K
-
E
G
E
----
N
V
V
G
S
E
T
R
V
K
V
V
K
N
K
I
A
A
P
F
K
Q
A
E
F
Q
I
L
Y
G
E
G
I
N
F
Y
G
E
L
V
D
L
G
V
K
E
K
L
I
E
K
A
G
A
W
Y
S
Y
K
G
E
K
I
G
Q
G
K
A
N
A
T
A
W
L
K
D
N
P
E
T
A
K
E
I
E
K
K
V
R
----
E
L
L
L
S
N
P
N
S
A
I
D
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
43
PsiBlast_CBE
94.63
62%
-85
- C3 -
3CMT
5
RECA_ECOLI
A:
[328-648]
----------------
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
G
E
D
R
S
M
D
V
E
T
I
S
T
G
S
L
S
L
D
I
A
L
G
A
G
G
L
P
M
G
R
I
V
E
I
Y
G
P
E
S
S
G
K
T
T
L
T
L
Q
V
I
A
A
A
Q
R
E
G
K
T
C
A
F
I
D
A
E
H
A
L
D
P
I
Y
A
R
K
L
G
V
D
I
D
N
L
L
C
S
Q
P
D
T
G
E
Q
A
L
E
I
C
D
A
L
A
R
S
G
A
V
D
V
I
V
V
D
S
V
A
A
L
T
P
K
A
E
I
E
G
E
I
G
D
S
H
M
G
L
A
A
R
M
M
S
Q
A
M
R
K
L
A
G
N
L
K
Q
S
N
T
L
L
I
F
I
N
Q
I
R
M
K
I
G
V
M
F
G
N
P
E
T
T
T
G
G
N
A
L
K
F
Y
A
S
V
R
L
D
I
R
R
I
G
A
V
K
-----
E
G
E
N
V
V
G
S
E
T
R
V
K
V
V
K
N
K
I
A
A
P
F
K
Q
A
E
F
Q
I
L
Y
G
E
G
I
N
F
Y
G
E
L
V
D
L
G
V
K
E
K
L
I
E
K
A
G
A
W
Y
S
Y
K
G
E
K
I
G
Q
G
K
A
N
A
T
A
W
L
K
D
N
P
E
T
A
K
E
I
E
K
K
V
R
----
E
L
L
L
S
N
P
N
S
A
I
D
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
37
PsiBlast_CBE
94.37
62%
-88
- C3 -
3CMU
7
RECA_ECOLI
A:
[328-648]
----------------
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
G
E
D
R
S
M
D
V
E
T
I
S
T
G
S
L
S
L
D
I
A
L
G
A
G
G
L
P
M
G
R
I
V
E
I
Y
G
P
E
S
S
G
K
T
T
L
T
L
Q
V
I
A
A
A
Q
R
E
G
K
T
C
A
F
I
D
A
E
H
A
L
D
P
I
Y
A
R
K
L
G
V
D
I
D
N
L
L
C
S
Q
P
D
T
G
E
Q
A
L
E
I
C
D
A
L
A
R
S
G
A
V
D
V
I
V
V
D
S
V
A
A
L
T
P
K
A
E
I
E
G
E
I
G
D
S
H
M
G
L
A
A
R
M
M
S
Q
A
M
R
K
L
A
G
N
L
K
Q
S
N
T
L
L
I
F
I
N
Q
I
R
M
K
I
G
V
M
F
G
N
P
E
T
T
T
G
G
N
A
L
K
F
Y
A
S
V
R
L
D
I
R
R
I
G
A
V
K
-----
E
G
E
N
V
V
G
S
E
T
R
V
K
V
V
K
N
K
I
A
A
P
F
K
Q
A
E
F
Q
I
L
Y
G
E
G
I
N
F
Y
G
E
L
V
D
L
G
V
K
E
K
L
I
E
K
A
G
A
W
Y
S
Y
K
G
E
K
I
G
Q
G
K
A
N
A
T
A
W
L
K
D
N
P
E
T
A
K
E
I
E
K
K
V
R
----
E
L
L
L
S
N
P
N
S
A
I
D
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
66
HHSearch
94.36
62%
-86
- C3 -
3CMU
7
RECA_ECOLI
A:
[332-656]
--------------------
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
G
E
D
R
S
M
D
V
E
T
I
S
T
G
S
L
S
L
D
I
A
L
G
A
G
G
L
P
M
G
R
I
V
E
I
Y
G
P
E
S
S
G
K
T
T
L
T
L
Q
V
I
A
A
A
Q
R
E
G
K
T
C
A
F
I
D
A
E
H
A
L
D
P
I
Y
A
R
K
L
G
V
D
I
D
N
L
L
C
S
Q
P
D
T
G
E
Q
A
L
E
I
C
D
A
L
A
R
S
G
A
V
D
V
I
V
V
D
S
V
A
A
L
T
P
K
A
E
I
E
G
E
I
G
D
S
H
M
G
L
A
A
R
M
M
S
Q
A
M
R
K
L
A
G
N
L
K
Q
S
N
T
L
L
I
F
I
N
Q
I
R
M
K
I
G
V
M
F
G
N
P
E
T
T
T
G
G
N
A
L
K
F
Y
A
S
V
R
L
D
I
R
R
I
G
A
V
K
-
E
G
E
----
N
V
V
G
S
E
T
R
V
K
V
V
K
N
K
I
A
A
P
F
K
Q
A
E
F
Q
I
L
Y
G
E
G
I
N
F
Y
G
E
L
V
D
L
G
V
K
E
K
L
I
E
K
A
G
A
W
Y
S
Y
K
G
E
K
I
G
Q
G
K
A
N
A
T
A
W
L
K
D
N
P
E
T
A
K
E
I
E
K
K
V
R
----
E
L
L
L
S
N
P
N
S
A
I
D
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
29
PsiBlast_CBE
94.26
61%
-91
- C3 -
1MO6
1
RECA_MYCTU
A:
[6-329]
-----------------
D
R
E
K
A
L
E
L
A
V
A
Q
I
E
K
S
Y
G
K
G
S
V
M
R
L
G
D
E
A
R
Q
P
I
S
V
I
P
T
G
S
I
A
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
V
A
A
F
I
D
A
E
H
A
L
D
P
D
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
I
R
S
G
A
L
D
I
V
V
I
D
S
V
A
A
L
V
P
R
A
E
L
E
-------
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
-------------
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
M
D
V
R
R
V
E
T
L
K
D
G
T
-----
N
A
V
G
N
R
T
R
V
K
V
V
K
N
K
C
L
A
P
F
K
Q
A
E
F
D
I
L
Y
G
K
G
I
S
R
E
G
S
L
I
D
M
G
V
D
Q
G
L
I
R
K
S
G
A
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
N
F
L
V
E
N
A
D
V
A
D
E
I
E
K
K
I
K
----
E
K
L
G
----------------------------------
39
PsiBlast_CBE
94.22
62%
-84
- C3 -
3CMX
5
RECA_ECOLI
A:
[328-648]
----------------
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
G
E
D
R
S
M
D
V
E
T
I
S
T
G
S
L
S
L
D
I
A
L
G
A
G
G
L
P
M
G
R
I
V
E
I
Y
G
P
E
S
S
G
K
T
T
L
T
L
Q
V
I
A
A
A
Q
R
E
G
K
T
C
A
F
I
D
A
E
H
A
L
D
P
I
Y
A
R
K
L
G
V
D
I
D
N
L
L
C
S
Q
P
D
T
G
E
Q
A
L
E
I
C
D
A
L
A
R
S
G
A
V
D
V
I
V
V
D
S
V
A
A
L
T
P
K
A
E
I
E
G
E
I
G
D
S
H
M
G
L
A
A
R
M
M
S
Q
A
M
R
K
L
A
G
N
L
K
Q
S
N
T
L
L
I
F
I
N
Q
I
R
M
K
I
G
V
M
F
G
N
P
E
T
T
T
G
G
N
A
L
K
F
Y
A
S
V
R
L
D
I
R
R
I
G
A
V
K
-----
E
G
E
N
V
V
G
S
E
T
R
V
K
V
V
K
N
K
I
A
A
P
F
K
Q
A
E
F
Q
I
L
Y
G
E
G
I
N
F
Y
G
E
L
V
D
L
G
V
K
E
K
L
I
E
K
A
G
A
W
Y
S
Y
K
G
E
K
I
G
Q
G
K
A
N
A
T
A
W
L
K
D
N
P
E
T
A
K
E
I
E
K
K
V
R
----
E
L
L
L
S
N
P
N
S
A
I
D
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
15
PsiBlast_PDB
94.08
61%
-88
- C3 -
2ZRM
3
RECA_MYCS2
A:
[7-331]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
E
M
G
D
S
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
R
----------
E
T
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
I
G
A
V
------------------------------
28
PsiBlast_CBE
93.92
61%
-91
- C3 -
2ZRH
1
RECA_MYCS2
A:
[7-331]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
E
M
G
D
S
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
A
L
R
--------
S
P
E
T
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
I
---------------------------------
38
PsiBlast_CBE
93.89
62%
-85
- C3 -
3CMX
7
RECA_ECOLI
D:
[328-648]
----------------
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
G
E
D
R
S
M
D
V
E
T
I
S
T
G
S
L
S
L
D
I
A
L
G
A
G
G
L
P
M
G
R
I
V
E
I
Y
G
P
E
S
S
G
K
T
T
L
T
L
Q
V
I
A
A
A
Q
R
E
G
K
T
C
A
F
I
D
A
E
H
A
L
D
P
I
Y
A
R
K
L
G
V
D
I
D
N
L
L
C
S
Q
P
D
T
G
E
Q
A
L
E
I
C
D
A
L
A
R
S
G
A
V
D
V
I
V
V
D
S
V
A
A
L
T
P
K
A
E
I
E
G
E
I
G
D
S
H
M
G
L
A
A
R
M
M
S
Q
A
M
R
K
L
A
G
N
L
K
Q
S
N
T
L
L
I
F
I
N
Q
I
R
M
K
I
G
V
M
F
G
N
P
E
T
T
T
G
G
N
A
L
K
F
Y
A
S
V
R
L
D
I
R
R
I
G
A
V
K
-----
E
G
E
N
V
V
G
S
E
T
R
V
K
V
V
K
N
K
I
A
A
P
F
K
Q
A
E
F
Q
I
L
Y
G
E
G
I
N
F
Y
G
E
L
V
D
L
G
V
K
E
K
L
I
E
K
A
G
A
W
Y
S
Y
K
G
E
K
I
G
Q
G
K
A
N
A
T
A
W
L
K
D
N
P
E
T
A
K
E
I
E
K
K
V
R
----
E
L
L
L
S
N
P
N
S
A
I
D
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
16
PsiBlast_PDB
93.89
61%
-89
- C3 -
2ZRO
2
RECA_MYCS2
A:
[7-331]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
E
M
G
D
S
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
R
E
K
I
G
------
E
T
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
I
G
A
V
------------------------------
20
PsiBlast_PDB
93.55
61%
-86
- C3 -
2ZRC
3
RECA_MYCS2
A:
[7-331]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
E
M
G
D
S
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
N
L
R
--------
S
P
E
T
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
I
G
A
V
------------------------------
32
PsiBlast_CBE
93.39
61%
-86
- C3 -
1MO3
1
RECA_MYCTU
A:
[6-329]
-----------------
D
R
E
K
A
L
E
L
A
V
A
Q
I
E
K
S
Y
G
K
G
S
V
M
R
L
G
D
E
A
R
Q
P
I
S
V
I
P
T
G
S
I
A
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
V
A
A
F
I
D
A
E
H
A
L
D
P
D
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
I
R
S
G
A
L
D
I
V
V
I
D
S
V
A
A
L
V
P
R
A
E
L
E
G
E
M
---
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
R
-------------
T
G
G
K
A
L
K
F
Y
A
S
V
R
M
D
V
R
R
V
E
T
L
K
D
G
T
-----
N
A
V
G
N
R
T
R
V
K
V
V
K
N
K
C
L
A
P
F
K
Q
A
E
F
D
I
L
Y
G
K
G
I
S
R
E
G
S
L
I
D
M
G
V
D
Q
G
L
I
R
K
S
G
A
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
N
F
L
V
E
N
A
D
V
A
D
E
I
E
K
K
I
K
----
E
K
L
G
----------------------------------
19
PsiBlast_PDB
93.37
61%
-91
- C3 -
2ZRA
5
RECA_MYCS2
A:
[7-330]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
E
M
G
--
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
E
L
R
-------------
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
----------------------------------
27
PsiBlast_CBE
93.07
61%
-90
- C3 -
2ZRJ
5
RECA_MYCS2
A:
[7-331]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
E
M
---
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
A
L
R
----------
E
T
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
I
---------------------------------
23
PsiBlast_CBE
93.00
61%
-91
- C3 -
2ZRE
3
RECA_MYCS2
A:
[7-331]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
E
M
G
D
S
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
N
L
R
----------
E
T
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
I
G
A
V
------------------------------
24
PsiBlast_CBE
92.90
61%
-85
- C3 -
2ZRD
1
RECA_MYCS2
A:
[7-331]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
E
M
G
D
S
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
N
L
R
E
--------
P
E
T
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
I
G
A
V
------------------------------
26
PsiBlast_CBE
92.89
61%
-89
- C3 -
2ZRK
1
RECA_MYCS2
A:
[7-331]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
E
M
G
D
S
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
A
L
R
----------
E
T
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
I
G
A
V
------------------------------
22
PsiBlast_CBE
92.70
61%
-91
- C3 -
2ZRF
1
RECA_MYCS2
A:
[7-330]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
E
M
G
D
S
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
N
L
R
----------
E
T
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
---------
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
----------------------------------
17
PsiBlast_PDB
92.70
61%
-86
- C3 -
2ZRP
1
RECA_MYCS2
A:
[7-331]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
-----
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
R
-------------
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
I
---------------------------------
30
PsiBlast_CBE
92.61
61%
-85
- C3 -
1MO5
1
RECA_MYCTU
A:
[6-329]
-----------------
D
R
E
K
A
L
E
L
A
V
A
Q
I
E
K
S
Y
G
K
G
S
V
M
R
L
G
D
E
A
R
Q
P
I
S
V
I
P
T
G
S
I
A
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
V
A
A
F
I
D
A
E
H
A
L
D
P
D
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
I
R
S
G
A
L
D
I
V
V
I
D
S
V
A
A
L
V
P
R
A
E
L
E
G
E
M
G
D
S
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
------------
T
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
M
D
V
R
R
V
E
T
L
K
D
G
T
-----
N
A
V
G
N
R
T
R
V
K
V
V
K
N
K
C
L
A
P
F
K
Q
A
E
F
D
I
L
Y
G
K
G
I
S
R
E
G
S
L
I
D
M
G
V
D
Q
G
L
I
R
K
S
G
A
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
N
F
L
V
E
N
A
D
V
A
D
E
I
E
K
K
I
K
----
E
K
L
G
----------------------------------
36
PsiBlast_CBE
92.41
60%
-87
- C3 -
1XMS
2
RECA_ECOLI
A:
[8-332]
----------------
E
N
K
Q
K
A
L
A
A
A
L
G
Q
I
E
K
Q
F
G
K
G
S
I
M
R
L
G
E
D
R
S
M
D
V
E
T
I
S
T
G
S
L
S
L
D
I
A
L
G
A
G
G
L
P
M
G
R
I
V
E
I
Y
G
P
E
S
S
G
K
T
T
L
T
L
Q
V
I
A
A
A
Q
R
E
G
K
T
C
A
F
I
D
A
E
H
A
L
D
P
I
Y
A
R
K
L
G
V
D
I
D
N
L
L
C
S
Q
P
D
T
G
E
Q
A
L
E
I
C
D
A
L
A
R
S
G
A
V
D
V
I
V
V
D
S
V
A
A
L
T
P
K
A
E
I
E
----------
A
A
R
M
M
S
Q
A
M
R
K
L
A
G
N
L
K
Q
S
N
T
L
L
I
F
I
N
Q
I
----------------
G
N
A
L
K
F
Y
A
S
V
R
L
D
I
R
R
I
G
A
V
K
-----
E
G
E
N
V
V
G
S
E
T
R
V
K
V
V
K
N
K
I
A
A
P
F
K
Q
A
E
F
Q
I
L
Y
G
E
G
I
N
F
Y
G
E
L
V
D
L
G
V
K
E
K
L
I
E
K
A
G
A
W
Y
S
Y
K
G
E
K
I
G
Q
G
K
A
N
A
T
A
W
L
K
D
N
P
E
T
A
K
E
I
E
K
K
V
R
E
L
L
L--------------------------------------
31
PsiBlast_CBE
92.30
61%
-83
- C3 -
1MO4
1
RECA_MYCTU
A:
[6-329]
-----------------
D
R
E
K
A
L
E
L
A
V
A
Q
I
E
K
S
Y
G
K
G
S
V
M
R
L
G
D
E
A
R
Q
P
I
S
V
I
P
T
G
S
I
A
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
V
A
A
F
I
D
A
E
H
A
L
D
P
D
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
I
R
S
G
A
L
D
I
V
V
I
D
S
V
A
A
L
V
P
R
A
E
L
E
G
-----
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
R
D
K
I
G
V
M
F
G
S
P
E
T
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
M
D
V
R
R
V
E
T
L
K
D
G
T
-----
N
A
V
G
N
R
T
R
V
K
V
V
K
N
K
C
L
A
P
F
K
Q
A
E
F
D
I
L
Y
G
K
G
I
S
R
E
G
S
L
I
D
M
G
V
D
Q
G
L
I
R
K
S
G
A
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
N
F
L
V
E
N
A
D
V
A
D
E
I
E
K
K
I
K
----
E
K
L
G
----------------------------------
7
PsiBlast_PDB
92.28
61%
-90
- C3 -
2G88
4
RECA_MYCS2
A:
[7-331]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
------
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
R
------------
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
I
G
A
V
V
T
A
E
A
D
D
V
L
P
A
P
V
D
F
---------------
9
PsiBlast_PDB
92.16
61%
-86
- C3 -
2ODW
1
RECA_MYCS2
A:
[7-331]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
------
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
R
E
------------
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
I
---------------------------------
21
PsiBlast_CBE
92.06
61%
-87
- C3 -
2ZRG
1
RECA_MYCS2
A:
[7-331]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
-----
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
N
L
R
E
------------
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
I
---------------------------------
33
PsiBlast_CBE
91.90
61%
-86
- C3 -
1G18
2
RECA_MYCTU
A:
[6-329]
-----------------
D
R
E
K
A
L
E
L
A
V
A
Q
I
E
K
S
Y
G
K
G
S
V
M
R
L
G
D
E
A
R
Q
P
I
S
V
I
P
T
G
S
I
A
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
V
A
A
F
I
D
A
E
H
A
L
D
P
D
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
I
R
S
G
A
L
D
I
V
V
I
D
S
V
A
A
L
V
P
R
A
E
L
E
G
E
M
---
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
--------------
T
G
G
K
A
L
K
F
Y
A
S
V
R
M
D
V
R
R
V
E
T
L
K
D
G
T
-----
N
A
V
G
N
R
T
R
V
K
V
V
K
N
K
C
L
A
P
F
K
Q
A
E
F
D
I
L
Y
G
K
G
I
S
R
E
G
S
L
I
D
M
G
V
D
Q
G
L
I
R
K
S
G
A
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
N
F
L
V
E
N
A
D
V
A
D
E
I
E
K
K
I
K
----
E
K
L
G
----------------------------------
11
PsiBlast_PDB
91.55
61%
-82
- C3 -
2OEP
1
RECA_MYCS2
A:
[7-330]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
E
M
G
D
S
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
-
E
K
I
G
V
M
F
G
S
P
E
T
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
----------------------------------
5
PsiBlast_PDB
91.15
61%
-84
- C3 -
1UBF
1
RECA_MYCS2
A:
[7-331]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
-------
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
R
E
K
I
----------
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
I
---------------------------------
4
PsiBlast_PDB
90.51
61%
-85
- C3 -
1UBE
1
RECA_MYCS2
A:
[7-330]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
--------
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
---------------
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
----------------------------------
25
PsiBlast_CBE
89.94
61%
-79
- C3 -
2ZRL
1
RECA_MYCS2
A:
[7-330]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
E
------
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
A
L
--------------
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
----------------------------------
8
PsiBlast_PDB
89.54
61%
-82
- C3 -
2ODN
1
RECA_MYCS2
A:
[7-330]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
E
--
D
S
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
--------------
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
----------------------------------
6
PsiBlast_PDB
88.92
61%
-80
- C3 -
1UBG
1
RECA_MYCS2
A:
[7-330]
-----------------
D
R
E
K
A
L
E
L
A
M
A
Q
I
D
K
N
F
G
K
G
S
V
M
R
L
G
E
E
V
R
Q
P
I
S
V
I
P
T
G
S
I
S
L
D
V
A
L
G
I
G
G
L
P
R
G
R
V
I
E
I
Y
G
P
E
S
S
G
K
T
T
V
A
L
H
A
V
A
N
A
Q
A
A
G
G
I
A
A
F
I
D
A
E
H
A
L
D
P
E
Y
A
K
K
L
G
V
D
T
D
S
L
L
V
S
Q
P
D
T
G
E
Q
A
L
E
I
A
D
M
L
V
R
S
G
A
L
D
I
I
V
I
D
S
V
A
A
L
V
P
R
A
E
I
E
G
E
M
G
D
S
H
V
G
L
Q
A
R
L
M
S
Q
A
L
R
K
M
T
G
A
L
N
N
S
G
T
T
A
I
F
I
N
Q
L
R
E
K
I
G
V
M
F
G
S
P
E
T
T
T
G
G
K
A
L
K
F
Y
A
S
V
R
L
D
V
R
R
I
E
T
L
K
D
G
T
-----
D
A
V
G
N
R
T
R
V
K
V
V
K
N
K
V
S
P
P
F
K
Q
A
E
F
D
I
L
Y
G
Q
G
I
S
R
E
G
S
L
I
D
M
G
V
E
H
G
F
I
R
K
S
G
S
W
F
T
Y
E
G
E
Q
L
G
Q
G
K
E
N
A
R
K
F
L
L
E
N
T
D
V
A
N
E
I
E
K
K
I
K
----
E
K
L
G
----------------------------------