@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2052: (2015-12-12 )
MSKIIELPDILANQIAAGEVVERPSSVVKELVENAIDAGSSQITIEVEESGLKKIQITDNGEGMTSEDAVLSLRRHATSKIKSQSDLFRIRTLGFRGEALPSIASISLMTIKTATEQGKQGTLLVAKGGNIEKQEVVSSPRGTKILVENLFFNTPARLKYMKSLQSELAHIIDIVNRLSLAHPEVAFTLINDGKEMTKTSGTGDLRQAIAGIYGLNTAKKMIEISNADLDFEISGYVSLPELTRANRNYITLLINGRYIKNFLLNRSILDGYGSKLMVGRFPIAVIDIQIDPYLADVNVHPTKQEVRISKERELMSLISTAISESLKQYDLIPDALENLAKTSTRSVDKPIQTSFSLKQPGLYYDRAKNDFFIGADTVSEPIANFTNLDKSDGSVDNDVKNSVNQGATQSPNIKYASRDQADSENFIHSQDYLSSKQSLNKLVEKLDSEESSTFPELEFFGQMHGTYLFAQGNGGLYIIDQHAAQERVKYEYYREKIGEVDNSLQQLLVPFLFEFSSSDFLQLQEKMSLLQDVGIFLEPYGNNTFILREHPIWMKEEEVESGIYEMCDMLLLTNEVSVKKYRAELAIMMSCKRSIKANHTLDDYSARHLLDQLAQCKNPYNCPHGRPVLVNFTKADMEKMFKRIQENHTSLRDLGKY
Atome Classification :
(20 SA)
-.........10........-20........30........40........50........60........70........80........90........100.......110.......120-......--.-130.-.......140.......150.......-160-.......170.......180.......190--..-----..--....200-..---.--------......210.......220.---------------...------------.-----------..---230.--......240-.--.......250........260.......270.......280.........290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MSKII
E
L
P
D
I
L
A
N
QIAA
G
E
-
V
VE
R
P
S
S
V
V
K
E
L
V
E
N
A
I
DAGS
S
Q
I
T
I
E
V
E
ESG
L
K
K
I
Q
I
TDNGEGMT
S
E
D
A
V
L
S
L
R
R
H
A
T
S
KIKSQSD
L
F
R
I
R
TLGFRGEALPSI
A
S
I
S
L
M
T
I
K
TATEQGKQ
G
T
-
L
L
V
AKG--G-NI-
E
-
K
Q
E
VVSSPRG
T
K
I
L
V
E
N
LFFN
T
P
A
R
L
K
-
Y
M
K
-
S
L
Q
S
E
L
A
H
I
I
D
I
V
N
R
LSLAHP
E
V
A
F
T
L
IN---DG-----KE--MTKTS---G
T
---
G
--------
D
L
R
Q
A
I
A
G
I
YGL
N
T
A
K
K
M
I
E
---------------ISN------------A-----------
D
L
---
D
F
E
I--SGYVS
L
P
E
--
L
--TRANR
N
Y
I
T
-
L
L
IN
G
R
Y
I
K
N
F
L
LN
R
S
I
L
D
GYGS
K
L
M
VGR--F
P
I
A
V
I
D
I
Q
ID
P
Y
L
ADVNVHP
T
K
Q
E
V
R
I
S
K
E
R
E
L
M
S
L
I
S
T
A
I
S
E
S
L
K
QYDL
I
P
D
A
L
E
N
L
A
K
TSTRSVDKPIQTSFSLKQPG
L
Y
Y
DRAKN
D
F
F
I
G
A
D
T
V
S
E
P
I
A
N
FTNLDKSDGSVD
N
D
V
K
N
S
V
NQGATQSPN
I
K
Y
ASRDQADSENFI
H
S
Q
D
Y
L
S
S
K
Q
S
L
N
K
L
V
E
K
LDSEESSTF
P
E
L
E
F
F
G
QMH
G
T
Y
L
F
A
QGNG
G
L
Y
I
IDQHA
A
Q
E
R
V
K
Y
E
Y
Y
R
E
K
I
G
E
V
D
N
S
L
Q
Q
L
L
V
P
F
L
F
EFSS
S
D
F
L
Q
L
Q
E
K
M
S
L
L
Q
DV
G
I
F
L
E
PYGN
N
T
F
I
L
REHPIW
M
K
E
E
E
V
E
S
G
I
Y
E
M
C
D
M
L
L
LTNE
V
S
V
K
K
Y
R
A
E
L
A
I
M
M
S
C
K
R
SIKANHTL
D
D
Y
S
A
R
H
L
L
D
Q
L
A
QCKNPYNCPHG
R
P
V
L
V
NF
T
K
A
D
M
E
K
M
F
K
R
I
Q
E
N
H
T
S
L
R
D
LGKY
42
Fugue
85.70
39%
-75
- C1 -
1B63
4
MUTL_ECOLI
A:
[1-333]
S
H
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
-
E
V
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
-
Q
A
Y
A
E
G
RD
M
-
N
V
---
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-R
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---
N
-------
G
-----
K
I
---
V
R
---
Q
Y
R
A
VPEGG
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
A
L
A
---------------
I
E
W
------------
Q
-----------
H
-G--
D
L
T
L
--
R
G
W
V
A
D
P
N
---HT
T
P
A
L
A
E
I
Q
Y
-
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
--
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.11
39%
-71
- C1 -
1NHJ
3
MUTL_ECOLI
A:
[8-333]
-------
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
I
I
S
L
G
F
R
G
E
A
L
P
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
-
Q
A
Y
A
E
G
--
R
-
D
M
-
N
V
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---
N
G
-----
K
I
--
V
R
Q
Y
R
---
A
V
PEG
G
--------
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
A
L
A
---------------
I
E
W
------------
Q
-----------
H
G
---
D
L
T
L
--
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
--
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
84.30
39%
-71
* C1 *
1B63
4
MUTL_ECOLI
A:
[2-333]
-
H
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
-
Q
A
Y
A
E
G
--
R
-
D
M
N
V
-
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---
N
G
-----
K
I
--
V
R
Q
Y
R
A
VP
E
G
---
G
--------
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
A
L
A
---------------
I
E
W
------------
Q
-----------
H
G
---
D
L
T
L
--
R
G
W
V
A
D
P
N
--
H
T-
T
P
A
L
A
E
I
Q
Y
-
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
--
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
82.50
38%
-70
- C1 -
1B63
4
MUTL_ECOLI
A:
[8-333]
-------
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
-
Q
A
Y
A
E
G
--
R
-
D
M
-
N
V
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---
N
G
-----
K
I
--
V
R
Q
Y
R
---
A
V
PEG
G
--------
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
A
L
A
---------------
I
E
W
------------
Q
-----------
H
G
---
D
L
T
L
--
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
--
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
81.84
38%
-72
- C1 -
1NHI
5
MUTL_ECOLI
A:
[8-333]
-------
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
-
Q
A
Y
A
E
G
--
R
-
D
M
-
N
V
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---
N
G
-----
K
I
--
V
R
Q
Y
R
---
A
V
P
EG
G
--------
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
A
L
A
---------------
I
E
W
------------
Q
-----------
H
G
---
D
L
T
L
--
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
--
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.57
38%
-72
- C1 -
1NHH
8
MUTL_ECOLI
A:
[8-333]
-------
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
-
Q
A
Y
A
E
G
--
R
-
D
M
-
N
V
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---
N
G
-----
K
I
--
V
R
Q
Y
R
---
A
V
P-----------
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
A
L
A
---------------
I
E
W
------------
Q
-----------
H
G
---
D
L
T
L
--
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
--
Q
--
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
77.20
27%
-75
- C1 -
3H4L
2
PMS1_YEAST
A:
[13-363]
-----------
D
V
H
R
I
T
S
G
Q
-
V
I
T
D
L
T
T
A
V
K
E
L
V
D
N
S
I
D
A
N
A
N
Q
I
E
I
I
F
K
D
Y
G
L
E
S
I
E
C
S
D
N
G
D
G
I
D
P
S
N
Y
E
F
L
A
L
K
H
Y
T
---------
A
K
V
Q
T
L
G
F
R
G
E
A
L
S
S
L
C
G
I
A
K
L
S
V
I
T
T
T
S
P
-
P
K
A
D
-
K
L
E
Y
D
M
--
V
G
H
I
-
T
-
S
K
T
T
T
S
R
N
K
G
T
T
V
L
V
S
Q
L
F
H
N
L
P
V
R
Q
K
-
E
F
S
K
T
F
K
R
Q
F
T
K
C
L
T
V
I
Q
G
Y
A
I
I
N
A
A
I
K
F
S
V
W
N
---
I
T
PK
G
K
K
N
L
--
I
L
S
T
M
---
R
N
---
S
--------
S
M
R
K
N
I
S
S
V
F
G
A
G
G
M
R
G
L
E
E
---------------
V
D
L
V
L
D
LNPFKNRML------------
D
Y
---
K
I
R
V
--
K
G
Y
I
S
Q
N
S
--
F
GC
G
R
N
S
K
D
R
Q
F
-
I
Y
V
N
K
R
P
V
E
Y
S
T
L
L
K
C
C
N
E
V
Y
K
T
F
-
N
N
V
Q
--
F
P
A
V
F
L
N
L
E
L
P
M
S
L
I
D
V
N
V
T
P
D
K
R
V
I
L
L
H
N
E
R
A
V
I
D
I
F
K
T
T
L
S
D
Y
Y
N
R
Q
E
L
A
L
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
77.18
26%
-75
- C1 -
3H4L
2
PMS1_YEAST
A:
[13-363]
-----------
D
V
H
R
I
T
S
G
Q
-
V
I
T
D
L
T
T
A
V
K
E
L
V
D
N
S
I
D
A
N
A
N
Q
I
E
I
I
F
K
D
Y
G
L
E
S
I
E
C
S
D
N
G
D
G
I
D
P
S
N
Y
E
F
L
A
L
K
H
Y
T
---------
A
K
V
Q
T
L
G
F
R
G
E
A
L
S
S
L
C
G
I
A
K
L
S
V
I
T
T
T
S
P
P
K
A
D
K
-
L
E
Y
D
M
V
--
G
-
H
I
-
T
-
S
K
T
T
T
S
R
N
K
G
T
T
V
L
V
S
Q
L
F
H
N
L
P
V
R
Q
K
E
F
S
K
-
T
F
K
R
Q
F
T
K
C
L
T
V
I
Q
G
Y
A
I
I
N
A
A
I
K
F
S
V
W
N
I
T
P
K
G
-----
K
K
N
L
I
L
S
T
M
---
R
N
---
S
--------
S
M
R
K
N
I
S
S
V
F
G
A
G
G
M
R
G
L
E
E
---------------
V
D
L
------------
V
L
D
LNPFKNRML-----
D
Y
K
I
R
V
K
G
Y
I
S
Q
N
S
--
F
GC
G
R
N
S
K
D
R
Q
F
-
I
Y
V
N
K
R
P
V
E
Y
S
T
L
L
K
C
C
N
E
V
Y
K
T
F
N
N
V
-
Q
--
F
P
A
V
F
L
N
L
E
L
P
M
S
L
I
D
V
N
V
T
P
D
K
R
V
I
L
L
H
N
E
R
A
V
I
D
I
F
K
T
T
L
S
D
Y
Y
N
R
Q
E
L
A
L
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
75.52
28%
-90
- C1 -
1EA6
2
PMS2_HUMAN
A:
[27-359]
----------------
C
S
G
Q
-
V
V
L
S
L
S
T
A
V
K
E
L
V
E
N
S
L
D
A
G
A
T
N
I
D
L
K
L
K
D
Y
G
V
D
L
I
E
V
S
D
N
G
C
G
V
E
E
E
N
F
E
G
L
T
L
-----------------------
E
A
L
S
S
L
C
A
L
S
D
V
T
I
S
T
C
H
A
S
A
K
V
G
T
R
L
M
F
D
H
N
--
G
-
K
I
-
I
-
Q
K
T
P
Y
P
R
P
R
G
T
T
V
S
V
Q
Q
L
F
S
T
L
P
V
R
H
K
E
F
Q
R
-
N
I
K
K
E
Y
A
K
M
V
Q
V
L
H
A
Y
C
I
I
S
A
G
I
R
V
S
C
T
N
Q
L
G
Q
G
-----
K
R
QP
V
V
C
T
G
---
G
S
---
P
--------
S
I
K
E
N
I
G
S
V
F
G
Q
K
Q
L
Q
S
L
I
P
F
V
Q
L
PPS
D
S
V
C
E
E
Y
G
L
S
C
------------
S
-----------
D
A
LHN
L
F
Y
I
--
S
G
F
I
S
Q
C
T
HG
V
--
G
R
S
S
T
D
R
Q
F
-
F
F
I
N
R
R
P
C
D
P
A
K
V
C
R
L
V
N
E
V
Y
H
---
M
Y
N
R
H
Q
Y
P
F
V
V
L
N
I
S
V
D
S
E
C
V
-----------
L
L
Q
E
E
K
L
L
L
A
V
L
K
T
S
L
I
G
M
F
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.34
28%
-90
- C1 -
1H7U
2
PMS2_HUMAN
A:
[31-359]
---------------------
V
V
L
S
L
S
T
A
V
K
E
L
V
E
N
S
L
D
A
G
A
T
N
I
D
L
K
L
K
D
Y
G
V
D
L
I
E
V
S
D
N
G
C
G
V
E
E
E
N
F
E
G
L
T
L
K
---------------------
G
E
A
L
S
S
L
C
A
L
S
D
V
T
I
S
T
C
H
A
S
A
K
V
G
T
R
L
M
F
D
H
N
--
G
-
K
I
-
I
-
Q
K
T
P
Y
P
R
P
R
G
T
T
V
S
V
Q
Q
L
F
S
T
L
P
V
R
H
K
E
F
Q
R
-
N
I
K
K
E
Y
A
K
M
V
Q
V
L
H
A
Y
C
I
I
S
A
G
I
R
V
S
C
T
N
Q
L
G
Q
G
-----
K
R
Q
P
V
V
C
T
G
---
G
S
---
P
--------
S
I
K
E
N
I
G
S
V
F
G
Q
K
Q
L
Q
S
L
I
P
F
V
Q
L
P
PS
D
S
V
C
E
E
Y
G
L
S
C
------------
S
-----------
D
A
LHN
L
F
Y
I
--
S
G
F
I
S
Q
C
T
HG
V
--
G
R
S
S
T
D
R
Q
F
-
F
F
I
N
R
R
P
C
D
P
A
K
V
C
R
L
V
N
E
V
Y
H
---
M
Y
N
R
HQ
Y
P
F
V
V
L
N
I
S
V
D
S
E
C
V
D
I
N
------
Q
I
L
L
Q
E
E
K
L
L
L
A
V
L
K
T
S
L
I
G
M
F
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.39
38%
-71
- C1 -
5AKD
-
?
C:
[40-351]
----------------------
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
S
G
I
K
K
D
E
L
A
L
A
L
A
------
I
A
S
L
D
D
L
E
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
-
Q
A
Y
A
---------
V
-
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---
N
G
-----
K
I
--
V
R
Q
Y
R
---
A
V
PEG
G
--------
Q
K
E
R
R
L
G
A
I
L
G
T
A
F
L
E
Q
A
L
A
---------------
I
E
W
------------
Q
-----------
H
G
---
D
L
T
L
--
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
F
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
Y
E
D
K
L
G
A
D
Q
--
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
69.81
38%
-68
- C1 -
5AKB
-
?
C:
[40-351]
----------------------
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
S
G
I
K
K
D
E
L
A
L
A
L
A
------
I
A
S
L
D
D
L
E
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
-
Q
A
Y
A
---------
V
-
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---
N
G
-----
K
I
--
V
R
Q
Y
R
---
A
V
PEG
G
--------
Q
K
E
R
R
L
G
A
I
L
G
T
A
F
L
E
Q
A
L
A
---------------
I
E
W
------------
Q
-----------
H
G
---
D
L
T
L
--
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
F
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
Y
E
D
K
L
G
A
D
Q
--
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
69.39
38%
-65
- C1 -
5AKC
-
?
C:
[40-351]
----------------------
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
S
G
I
K
K
D
E
L
A
L
A
L
A
------
I
A
S
L
D
D
L
E
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
-
Q
A
Y
A
---------
V
-
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---
N
G
-----
K
I
--
V
R
Q
Y
R
---
A
V
PEG
G
--------
Q
K
E
R
R
L
G
A
I
L
G
T
A
F
L
E
Q
A
L
A
---------------
I
E
W
------------
Q
-----------
H
G
---
D
L
T
L
--
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
F
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
Y
E
D
K
L
G
A
D
Q
--
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.16
47%
-105
- C2 -
3GAB
-
MUTL_BACSU
A:
[437-624]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
E
--
P
E
V
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
I
K
K
L
R
E
E
A
A
I
M
M
S
C
K
-----
N
R
H
L
R
N
D
E
I
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
---------------
5
PsiBlast_PDB
66.88
38%
-24
- C- -
1B62
2
MUTL_ECOLI
A:
[12-338]
-------
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
-
Q
A
Y
A
E
G
--
R
-
D
M
-
N
V
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---
N
G
-----
K
I
--
V
R
Q
Y
R
---
A
V
P
EG
G
--------
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
A
L
A
---------------
I
E
W
------------
Q
-----------
H
G
---
D
L
T
L
--
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
--
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
-
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.58
38%
-69
- C1 -
1BKN
-
MUTL_ECOLI
A:
[20-331]
----------------------
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
------
I
A
S
L
D
D
L
E
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
-
Q
A
Y
A
----------V
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
---------------
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
L
S
H
---
N
G
-----
K
I
--
V
R
Q
Y
R
---
A
V
P
EG
G
--------
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
E
Q
A
L
A
---------------
I
E
W
------------
Q
-----------
H
G
---
D
L
T
L
--
R
G
W
V
A
D
P
N
--
H
--
T
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
--
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
65.04
47%
-103
- C2 -
3KDG
-
MUTL_BACSU
A:
[434-626]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
V
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
E
V
E
P
E
V
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
I
K
K
L
R
E
E
A
A
I
M
M
S
C
K
G
----
N
R
H
L
R
N
D
E
I
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
R
V
-------------
11
PsiBlast_PDB
65.02
47%
-101
- C2 -
3KDG
-
MUTL_BACSU
A:
[437-626]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
E
V
E
P
E
V
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
I
K
K
L
R
E
E
A
A
I
M
M
S
C
K
G
----
N
R
H
L
R
N
D
E
I
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
R
V
-------------
21
PsiBlast_CBE
64.15
47%
-101
- C2 -
3KDK
2
B:
[7-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
E
V
E
P
E
V
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
I
K
K
L
R
E
E
A
A
I
M
M
S
C
K
------
R
H
L
R
N
D
E
I
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
---------------
45
Fugue
63.95
45%
-101
* C2 *
3KDG
-
MUTL_BACSU
A:
[433-627]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
R
V
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
E
V
E
P
E
V
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
I
K
K
L
R
E
E
A
A
I
M
M
S
C
K
----
G
N
R
H
L
R
N
D
E
I
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
R
V
M
------------