@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2060: (2015-12-12 )
MKRSMYAGRVRSEHIGTSITLKGWVGRRRDLGGLIFIDLRDREGIMQLVINPEEVAASVMATAESLRSEFVIEVSGVVTAREQANDNLPTGEVELKVQELSVLNTSKTTPFEIKDGIEANDDTRMRYRYLDLRRPEMLENFKLRAKVTHSIRNYLDNLEFIDVETPMLTKSTPEGARDYLVPSRVNQGHFYALPQSPQITKQLLMNAGFDRYYQIVKCFRDEDLRGDRQPEFTQVDLETSFLSDQEIQDIVEGMIAKVMKDTKGLEVSLPFPRMAYDDAMNNYGSDKPDTRFDMLLQDLTEIVKEVDFKVFSEASVVKAIVVKDKADKYSRKNIDKLTEIAKQYGAKGLAWLKYVDNTISGPVAKFLTAIEGRLTEALQLENNDLILFVADSLEVANETLGALRTRIAKELELIDYSKFNFLWVVDWPMFEWSEEEGRYMSAHHPFTLPTAETAHELEGDLAKVRAVAYDIVLNGYELGGGSLRINQKDTQERMFKALGFSAESAQEQFGFLLEAMDYGFPPHGGLAIGLDRFVMLLAGKDNIREVIAFPKNNKASDPMTQAPSLVSEQQLEELSLTVESYEN
Atome Classification :
(20 SA)
.........10........20........30........40........50...-.....60........70........80--.--..--...--..90........100....-...110....------------------------...120..------......130.......140.......150.......-160.......170.......180.......190.......200.......210.......220.......-230.......240-.......250.......260....----------------...270.......280.......290.......300.......310..-----.-----....320.......330.......340-.......350.......-----.360......-.-370.-.......380.......390.......400.......410-----.......420.......430...----------....440......-..450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKRSMYAGRV
R
S
EHIG
T
S
I
T
L
KGWVGRRRDLG
G
L
I
F
I
D
LRDRE
G
I
M
Q
L
V
I
N
P
E
E
-
V
A
A
S
V
M
A
T
A
E
S
L
R
S
E
F
V
I
E
VS
G
V
V
T
A
R
--
E
--QA--NDN--LPTG
E
V
E
L
K
V
Q
E
L
S
V
LNTS-KTT
P
F
E
IKDG------------------------IEAN-DDT------
R
M
R
Y
R
Y
LDLR
R
P
E
M
L
E
N
F
K
L
R
A
K
V
T
H
S
I
R
N
Y
LDN
L
E
-
F
I
DVETPMLTKSTPEGARDYLVPSRVNQG
H
F
Y
ALPQS
P
Q
I
T
K
Q
L
L
M
NA
G
F
D
R
Y
Y
Q
I
V
K
C
F
RDEDLRGDRQ-PE
F
T
Q
V
D
LETSFL-S
D
Q
E
I
Q
D
I
V
E
G
M
I
A
K
V
M
K
DTKG
L
E
----------------
V
SLPFP
R
M
A
Y
D
D
A
M
NNYGSDKP
D
T
R
F
D
M
L
L
Q
D
L
T
E
I
V
K
EV
D
F
K
VFSEA-----
S
-----
V
V
K
A
I
V
VKDKADKYSRK
N
I
D
K
L
T
E
I
A
K
-
Q
YGAK
G
L
A
W
-
L
K
Y
V
D
NT-----IS
G
P
V
A
K
F
L
T
-
A
-
I
E
-
G
-
R
L
T
E
A
L
Q
LENN
D
L
I
L
F
VAD
S
L
E
V
A
N
E
T
L
G
A
L
R
T
R
I
A
K
E
L
E
-----LIDYSK
F
N
F
L
W
V
VDWPMFEWSEE----------EG
R
Y
M-SAHHPFT-LP
T
A
E
T
A
H
E
LE
G
D
L
A
K
V
R
A
V
A
Y
D
I
V
L
N
G
Y
E
LGG
G
S
L
R
IN
Q
K
D
T
Q
E
R
M
F
K
A
LGFS
A
E
S
A
Q
E
Q
F
G
F
L
L
E
A
M
DYGFPPHG
G
L
A
I
G
L
D
R
F
V
M
L
LAGK
D
N
I
R
E
V
IAFPKNNKASDPMTQA
P
S
L
V
S
E
Q
Q
L
E
E
L
S
L
T
V
ESYEN
39
HHSearch
93.17
52%
-93
- C7 -
1L0W
-
SYD_THETH
A:
[1-579]
M
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
H
P
A
S
----
P
A
Y
A
T
A
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
--
P
--
E
P
--
N
P
R
--
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
F
P
V
D
A
G
WRG
E
E
E
------------------
K
E
A
S
-
E
E
L
------
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
E
G
-
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
E
----------------
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
-----
E
-----
S
V
K
A
L
A
L
P
K
---
A
L
S
R
K
E
V
A
E
L
E
E
V
A
K
-
R
H
K
A
Q
G
L
A
W
-
A
R
V
E
E
G
G
-----
F
S
G
G
V
A
K
F
L
E
-
P
-
V
R
-
E
-
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
-----
L
K
-
R
E
G
F
R
F
L
W
V
V
D
F
P
L
L
E
W
D
E
E
----------
E
E
A
W
T
-
Y
M
H
H
P
F
T
-
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
--
1
PsiBlast_PDB
92.44
50%
-95
- C7 -
1EFW
-
SYD_THETH
A:
[1-577]
M
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
H
P
----
A
S
P
A
Y
A
T
A
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
--
P
--
E
P
--
N
P
R
--
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
F
P
V
D
A
G
------------------------
W
R
G
E
-
E
E
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
E
G
-
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
E
----------------
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
-----
E
-----
S
V
K
A
L
A
L
---
P
K
A
L
S
R
K
E
V
A
E
L
E
E
V
A
K
-
R
H
K
A
Q
G
L
A
W
-
A
R
V
E
E
G
G
-----
F
S
G
G
V
A
K
F
L
E
-
P
-
V
R
-
E
-
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
-----
L
-
K
R
E
G
F
R
F
L
W
V
V
D
F
P
L
L
E
W
D
E
E
----------
E
E
A
W
T
-
Y
M
H
H
P
F
T
-
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
--
3
PsiBlast_PDB
92.19
50%
-96
- C7 -
1L0W
-
SYD_THETH
A:
[1-577]
M
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
H
P
----
A
S
P
A
Y
A
T
A
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
--
P
--
E
P
--
N
P
R
--
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
F
P
V
D
A
G
------------------------
W
R
G
E
-
E
E
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
E
G
-
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
E
----------------
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
-----
E
-----
S
V
K
A
L
A
L
---
P
K
A
L
S
R
K
E
V
A
E
L
E
E
V
A
K
-
R
H
K
A
Q
G
L
A
W
-
A
R
V
E
E
G
G
-----
F
S
G
G
V
A
K
F
L
E
-
P
-
V
R
-
E
-
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
-----
L
-
K
R
E
G
F
R
F
L
W
V
V
D
F
P
L
L
E
W
D
E
E
----------
E
E
A
W
T
-
Y
M
H
H
P
F
T
-
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
--
21
PsiBlast_CBE
91.45
50%
-96
- C7 -
1G51
3
SYD_THETH
B:
[1-577]
M
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
H
P
----
A
S
P
A
Y
A
T
A
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
--
P
--
E
P
--
N
P
R
--
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
F
P
V
D
A
G
------------------------
W
R
G
E
-
E
E
K
EASEEL
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
E
G
-
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
E
----------------
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
-----
E
-----
S
V
K
A
L
A
L
---
P
K
A
L
S
R
K
E
V
A
E
L
E
E
V
A
K
-
R
H
K
A
Q
G
L
A
W
-
A
R
V
E
E
G
G
-----
F
S
G
G
V
A
K
F
L
E
-
P
-
V
R
-
E
-
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
-----
L
-
K
R
E
G
F
R
F
L
W
V
V
D
F
P
L
L
E
W
D
E
E
----------
E
E
A
W
T
-
Y
M
H
H
P
F
T
-
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
--
2
PsiBlast_PDB
91.20
50%
-94
- C7 -
1G51
2
SYD_THETH
A:
[1-577]
M
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
H
P
----
A
S
P
A
Y
A
T
A
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
--
P
--
E
P
--
N
P
R
--
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
T
P
P
F
P
V
D
A
G
------------------------
W
R
G
E
-
E
E
K
EAS
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
E
G
-
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
E
----------------
L
P
L
P
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
E
A
-----
E
-----
S
V
K
A
L
A
L
---
P
K
A
L
S
R
K
E
V
A
E
L
E
E
V
A
K
-
R
H
K
A
Q
G
L
A
W
-
A
R
V
E
E
G
G
-----
F
S
G
G
V
A
K
F
L
E
-
P
-
V
R
-
E
-
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
G
-----
L
-
K
R
E
G
F
R
F
L
W
V
V
D
F
P
L
L
E
W
D
E
E
----------
E
E
A
W
T
-
Y
M
H
H
P
F
T
-
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
P
--
4
PsiBlast_PDB
90.04
49%
-89
- C7 -
1EQR
1
SYD_ECOLI
A:
[2-583]
--
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
---
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
--
D
--
E
K
--
N
I
N
RD
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
L
---
D
S
------------------------
N
H
V
N
T
E
E
A
------
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
H
G
-
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
K
G
V
D
----------------
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
-----
A
N
DPK
G
R
V
A
A
L
R
V
P
G
G
A
-
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
-
I
Y
G
A
K
G
L
A
Y
-
I
K
V
N
E
R
A
KGLEG
I
N
S
P
V
A
K
F
L
N
-
A
E
I
I
-
E
-
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
-----
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
E
-
D
D
G
----------
E
G
G
L
T
-
A
M
H
H
P
F
T
-
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
K
A
E
24
PsiBlast_CBE
89.99
49%
-89
- C7 -
1EQR
1
SYD_ECOLI
B:
[2-583]
--
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
---
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
--
D
--
E
K
--
N
I
N
RD
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
L
---
D
S
------------------------
N
H
V
N
T
E
E
A
------
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
H
G
-
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
K
G
V
D
----------------
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
-----
A
NDPKG
R
V
A
A
L
R
V
P
G
G
A
-
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
-
I
Y
G
A
K
G
L
A
Y
-
I
K
V
N
E
R
A
KGLEG
I
N
S
P
V
A
K
F
L
N
-
A
E
I
I
-
E
-
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
-----
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
E
-
D
D
G
----------
E
G
G
L
T
-
A
M
H
H
P
F
T
-
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
K
A
E
7
PsiBlast_PDB
89.90
48%
-95
- C7 -
4WJ3
-
SYDND_PSEAE
M:
[10-590]
-
M
R
S
H
Y
C
G
Q
L
N
E
S
L
D
G
Q
E
V
T
L
C
G
W
V
H
R
R
R
D
H
G
G
V
I
F
L
D
V
R
D
R
E
G
L
A
Q
V
V
F
D
P
D
R
---
A
E
T
F
A
K
A
D
R
V
R
S
E
F
V
V
K
I
T
G
K
V
R
L
R
--
P
--
E
G
AR
N
P
N
--
M
A
S
G
S
I
E
V
L
G
Y
E
L
E
V
L
N
Q
A
-
E
T
P
P
F
P
L
D
E
Y
------------------------
S
D
V
G
-
E
E
T
------
R
L
R
Y
R
F
I
D
L
R
R
P
E
M
A
A
K
L
K
L
R
A
R
I
T
S
S
I
R
R
Y
L
D
D
N
G
-
F
L
D
V
E
T
P
I
L
G
R
P
T
P
E
G
A
R
D
Y
L
V
P
S
R
T
Y
P
G
H
F
F
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
F
D
R
Y
Y
Q
I
A
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
I
E
T
S
F
L
-
D
E
S
D
I
I
G
I
T
E
K
M
V
R
Q
L
F
K
E
V
L
D
V
E
----------------
F
D
-
E
F
P
H
M
P
F
E
E
A
M
R
R
Y
G
S
D
K
P
D
L
R
I
P
L
E
L
V
D
V
A
D
Q
L
K
E
V
E
F
K
V
F
S
G
P
-----
A
NDPKG
R
V
A
A
L
R
V
P
G
A
A
-
S
M
P
R
S
Q
I
D
D
Y
T
K
F
V
G
-
I
Y
G
A
K
G
L
A
Y
-
I
K
V
N
E
R
A
KGVEG
L
Q
S
P
I
V
K
F
I
P
E
A
-
N
L
-
N
-
V
I
L
D
R
V
G
A
V
D
G
D
I
V
F
F
G
A
D
K
A
K
I
V
C
D
A
L
G
A
L
R
I
K
V
G
H
D
L
K
-----
L
L
T
-
R
E
W
A
P
M
W
V
V
D
F
P
M
F
E
-
E
N
D
----------
D
G
S
L
S
-
A
L
H
H
P
F
T
-
S
P
K
C
-
T
P
A
E
L
E
A
N
P
G
A
A
L
S
R
A
Y
D
M
V
L
N
G
T
E
L
G
G
G
S
I
R
I
H
D
K
S
M
Q
Q
A
V
F
R
V
L
G
I
D
E
A
E
Q
E
E
K
F
G
F
L
L
D
A
L
K
Y
G
A
P
P
H
G
G
L
A
F
G
L
D
R
L
V
M
L
M
T
G
A
S
S
I
R
E
V
I
A
F
P
K
T
Q
S
A
G
D
V
M
T
Q
A
P
G
S
V
D
G
K
A
L
R
E
L
H
I
R
L
R
E
Q
P
K
6
PsiBlast_PDB
89.72
49%
-87
- C7 -
1C0A
2
SYD_ECOLI
A:
[2-583]
--
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
---
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
--
D
--
E
K
--
N
I
N
RD
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
L
---
D
S
------------------------
N
H
V
N
T
E
E
A
------
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
H
G
-
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
K
G
V
D
----------------
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
-----
A
N
DPK
G
R
V
A
A
L
R
V
P
G
G
A
-
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
-
I
Y
G
A
K
G
L
A
Y
-
I
K
V
N
E
R
A
KGLEG
I
N
S
P
V
A
K
F
L
N
-
A
E
I
I
-
E
-
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
-----
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
E
-
D
D
G
----------
E
G
G
L
T
-
A
M
H
H
P
F
T
-
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
---
5
PsiBlast_PDB
89.70
49%
-90
- C7 -
1IL2
2
SYD_ECOLI
A:
[2-583]
--
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
---
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
--
D
--
E
K
--
N
I
N
RD
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
L
---
D
S
------------------------
N
H
V
N
T
E
E
A
------
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
H
G
-
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
K
G
V
D
----------------
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
-----
A
N
DPK
G
R
V
A
A
L
R
V
P
G
G
A
-
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
-
I
Y
G
A
K
G
L
A
Y
-
I
K
V
N
E
R
A
KGLEG
I
N
S
P
V
A
K
F
L
N
-
A
E
I
I
-
E
-
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
-----
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
E
-
D
D
G
----------
E
G
G
L
T
-
A
M
H
H
P
F
T
-
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
---
22
PsiBlast_CBE
89.44
49%
-89
- C7 -
1IL2
2
SYD_ECOLI
B:
[2-583]
--
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
---
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
--
D
--
E
K
--
N
I
N
RD
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
L
---
D
S
------------------------
N
H
V
N
T
E
E
A
------
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
H
G
-
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
K
G
V
D
----------------
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
-----
A
NDPKG
R
V
A
A
L
R
V
P
G
G
A
-
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
-
I
Y
G
A
K
G
L
A
Y
-
I
K
V
N
E
R
A
KGLEG
I
N
S
P
V
A
K
F
L
N
-
A
E
I
I
-
E
-
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
-----
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
E
-
D
D
G
----------
E
G
G
L
T
-
A
M
H
H
P
F
T
-
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
---
8
PsiBlast_PDB
89.26
48%
-90
- C7 -
4WJ4
1
SYDND_PSEAE
A:
[10-590]
-
M
R
S
H
Y
C
G
Q
L
N
E
S
L
D
G
Q
E
V
T
L
C
G
W
V
H
R
R
R
D
H
G
G
V
I
F
L
D
V
R
D
R
E
G
L
A
Q
V
V
F
D
P
D
R
---
A
E
T
F
A
K
A
D
R
V
R
S
E
F
V
V
K
I
T
G
K
V
R
L
R
--
P
--
E
G
AR
N
P
N
--
M
A
S
G
S
I
E
V
L
G
Y
E
L
E
V
L
N
Q
A
-
E
T
P
P
F
P
L
D
E
Y
------------------------
S
D
V
G
-
E
E
T
------
R
L
R
Y
R
F
I
D
L
R
R
P
E
M
A
A
K
L
K
L
R
A
R
I
T
S
S
I
R
R
Y
L
D
D
N
G
-
F
L
D
V
E
T
P
I
L
G
R
P
T
P
E
G
A
R
D
Y
L
V
P
S
R
T
Y
P
G
H
F
F
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
F
D
R
Y
Y
Q
I
A
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
I
E
T
S
F
L
-
D
E
S
D
I
I
G
I
T
E
K
M
V
R
Q
L
F
K
E
V
L
D
V
E
----------------
F
D
-
E
F
P
H
M
P
F
E
E
A
M
R
R
Y
G
S
D
K
P
D
L
R
I
P
L
E
L
V
D
V
A
D
Q
L
K
E
V
E
F
K
V
F
S
G
P
-----
A
NDPK
G
R
V
A
A
L
R
V
P
G
A
A
-
S
M
P
R
S
Q
I
D
D
Y
T
K
F
V
G
-
I
Y
G
A
K
G
L
A
Y
-
I
K
V
N
E
R
A
KGVEG
L
Q
S
P
I
V
K
F
I
P
E
A
-
N
L
-
N
-
V
I
L
D
R
V
G
A
V
D
G
D
I
V
F
F
G
A
D
K
A
K
I
V
C
D
A
L
G
A
L
R
I
K
V
G
H
D
L
K
-----
L
L
T
-
R
E
W
A
P
M
W
V
V
D
F
P
M
F
E
-
E
N
D
----------
D
G
S
L
S
-
A
L
H
H
P
F
T
-
S
P
K
C
-
T
P
A
E
L
E
A
N
P
G
A
A
L
S
R
A
Y
D
M
V
L
N
G
T
E
L
G
G
G
S
I
R
I
H
D
K
S
M
Q
Q
A
V
F
R
V
L
G
I
D
E
A
E
Q
E
E
K
F
G
F
L
L
D
A
L
K
Y
G
A
P
P
H
G
G
L
A
F
G
L
D
R
L
V
M
L
M
T
G
A
S
S
I
R
E
V
I
A
F
P
K
T
Q
S
A
G
D
V
M
T
Q
A
P
G
S
V
D
G
K
A
L
R
E
L
H
I
R
L
R
E
---
23
PsiBlast_CBE
88.76
49%
-91
- C7 -
1EQR
1
SYD_ECOLI
C:
[2-583]
--
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
---
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
--
D
--
E
K
--
N
I
N
RD
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
L
---
D
S
------------------------
N
H
V
N
T
E
E
A
------
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
H
G
-
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
K
G
V
D
----------------
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
-----
A
NDPKG
R
V
A
A
L
R
V
P
G
G
A
-
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
-
I
Y
G
A
K
G
L
A
Y
-
I
K
V
N
E
R
A
KGLEG
I
N
S
P
V
A
K
F
L
N
-
A
E
I
I
-
E
-
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
-----
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
E
-
D
D
G
----------
E
G
G
L
T
-
A
M
H
H
P
F
T
-
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
K
A
E
59
Fugue
88.73
49%
-87
- C7 -
1C0A
2
SYD_ECOLI
A:
[1-585]
-
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
-
A
D
A
L
K
L
A
--
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
DE
K
--
N
I
--
N
R
D
--
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
V
L
P
L
D
S
N
H
--------------------------
V
N
T
-
E
E
A
------
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
H
G
-
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
-
P
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
K
G
V
D
----------------
L
G
-
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
-----
A
N
DPK
G
R
V
A
A
L
R
V
P
G
-
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
-
I
Y
G
A
K
G
L
A
Y
-
I
K
V
N
E
R
A
KGLEG
I
N
S
P
V
A
K
F
L
N
-
A
-
E
I
I
E
-
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
G
-----
L
T
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
E
D
-
D
G
----------
E
G
G
L
T
-
A
M
H
H
P
F
T
-
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
---
10
PsiBlast_PDB
86.71
46%
-81
- C7 -
4O2D
3
SYDND_MYCS2
A:
[25-604]
--
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
R
-----
E
G
D
V
L
A
A
A
H
R
L
R
A
E
F
C
V
A
V
T
G
V
V
E
V
R
--
P
--
E
G
--
N
E
N
PE
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
S
-
A
P
L
P
F
Q
L
D
E
--------------------------
Q
A
G
-
E
E
A
------
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
H
D
-
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
--
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
-
E
A
D
D
V
I
A
I
S
E
-
Q
V
L
K
A
V
W
A
T
I
G
Y
D
----------------
L
P
L
P
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
K
D
T
T
F
R
V
F
-
Q
A
-----
P
-----
Y
V
G
A
V
V
M
P
G
G
A
S
Q
-
P
R
R
T
L
D
G
W
Q
E
F
A
K
-
Q
R
G
H
K
G
L
A
Y
V
L
V
G
E
D
G
T
-----
L
G
G
P
V
A
K
N
L
S
-
D
-
A
E
R
D
-
G
L
V
A
H
V
G
A
N
P
G
D
C
I
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
D
-----
L
I
D
P
N
A
W
A
F
T
W
V
V
D
F
P
M
F
E
A
A
D
E
A
T
A
A
GDVAVG
S
G
A
W
T
-
A
M
H
H
A
F
T
-
A
P
K
P
D
S
V
D
T
F
D
S
D
P
G
N
A
L
S
D
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
I
D
------
9
PsiBlast_PDB
86.37
46%
-79
- C7 -
4RMF
2
SYDND_MYCS2
A:
[2-580]
-
L
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
R
-----
E
G
D
V
L
A
A
A
H
R
L
R
A
E
F
C
V
A
V
T
G
V
V
E
V
R
--
P
--
E
G
--
N
E
N
PE
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
S
-
A
P
L
P
F
Q
L
D
E
--------------------------
Q
A
G
-
E
E
A
------
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
H
D
-
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
R
A
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
-
E
A
D
D
V
I
A
I
S
E
-
Q
V
L
K
A
V
W
A
T
I
G
Y
D
----------------
L
P
L
P
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
K
D
T
T
F
R
V
F
-
Q
A
-----
P
-----
Y
V
G
A
V
V
M
P
G
G
A
S
Q
-
P
R
R
T
L
D
G
W
Q
E
F
A
K
-
Q
R
G
H
K
G
L
A
Y
V
L
V
G
E
D
G
T
-----
L
G
G
P
V
A
K
N
L
S
-
D
-
A
E
R
D
-
G
L
V
A
H
V
G
A
N
P
G
D
C
I
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
D
-----
L
I
D
P
N
A
W
A
F
T
W
V
V
D
F
P
M
F
E
A
A
D
E
ATAAGDVAVG
S
G
A
W
T
-
A
M
H
H
A
F
T
-
A
P
K
P
D
S
V
D
T
F
D
S
D
P
G
N
A
L
S
D
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
--------
25
PsiBlast_CBE
84.67
46%
-76
- C7 -
4O2D
3
SYDND_MYCS2
B:
[25-604]
--
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
R
-----
E
G
D
V
L
A
A
A
H
R
L
R
A
E
F
C
V
A
V
T
G
V
V
E
V
R
--
P
--
E
G
--
N
E
N
PE
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
S
-
A
P
L
P
F
Q
L
D
E
--------------------------
Q
A
G
-
E
E
A
------
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
H
D
-
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
--
D
R
Q
-
P
E
F
T
Q
L
D
M
E
M
S
F
V
-
E
A
D
D
V
I
A
I
S
E
-
Q
V
L
K
A
V
W
A
T
I
G
Y
D
----------------
L
P
L
P
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
----------------
P
-----
Y
V
G
A
V
V
M
P
-------------
W
Q
E
F
A
K
-
Q
R
G
---------------------------------------------------
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
D
-----
L
I
D
P
N
A
W
A
F
T
W
V
V
D
F
P
M
F
E
A
A
D
E
A
T
A
A
GDVAVG
S
G
A
W
T
-
A
M
H
H
A
F
T
-
A
P
K
P
D
S
V
D
T
F
D
S
D
P
G
N
A
L
S
D
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
I
D
------
11
PsiBlast_PDB
82.80
40%
-80
- C7 -
4AH6
-
SYDM_HUMAN
A:
[50-630]
--
R
T
N
T
C
G
E
L
R
S
S
H
L
G
Q
E
V
T
L
C
G
W
I
Q
Y
R
R
Q
N
---
T
F
L
V
L
R
D
F
D
G
L
V
Q
V
I
I
P
Q
D
E
-
S
A
A
S
V
K
K
I
L
C
E
A
P
V
E
S
V
V
Q
V
S
G
T
V
I
S
R
--
P
AG
Q
E
--
N
P
K
--
M
P
T
G
E
I
E
I
K
V
K
T
A
E
L
L
N
A
C
-
K
K
L
P
F
E
I
K
N
F
------------------------
V
K
K
T
-
E
A
L
------
R
L
Q
Y
R
Y
L
D
L
R
S
F
Q
M
Q
Y
N
L
R
L
R
S
Q
M
V
M
K
M
R
E
Y
L
C
N
L
H
G
F
V
D
I
E
T
P
T
L
F
K
R
T
P
G
G
A
K
E
F
L
V
P
S
R
-
E
P
G
K
F
Y
S
L
P
Q
S
P
Q
Q
F
K
Q
L
L
M
V
G
G
L
D
R
Y
F
Q
V
A
R
C
Y
R
D
E
G
S
R
P
D
R
Q
-
P
E
F
T
Q
I
D
I
E
M
S
F
V
-
D
Q
T
G
I
Q
S
L
I
E
G
L
L
Q
Y
S
W
P
N
D
K
D
-
P
----------------
V
V
V
P
F
P
T
M
T
F
A
E
V
L
A
T
Y
G
T
D
K
P
D
T
R
F
G
M
K
I
I
D
I
S
D
V
F
R
N
T
E
I
G
F
L
Q
D
A
L
SKPH
G
-----
T
V
K
A
I
C
I
P
E
G
A
K
Y
L
K
R
K
D
I
E
S
I
R
N
F
A
A
D
H
F
N
Q
E
I
L
P
V
-
F
L
N
A
N
R
N
-----
W
N
S
P
V
A
N
F
I
M
-
E
-
S
Q
-
R
L
E
L
I
R
L
M
E
T
Q
E
E
D
V
V
L
L
T
A
G
E
H
N
K
A
C
S
L
L
G
K
L
R
L
E
C
A
D
L
L
E
T
RGVV
L
R
D
P
T
L
F
S
F
L
W
V
V
D
F
P
L
F
L
P
K
E
E
----------
N
P
R
E
L
E
S
A
H
H
P
F
T
-
A
P
H
P
S
D
I
H
L
L
Y
T
E
P
K
K
A
R
S
Q
H
Y
D
L
V
L
N
G
N
E
I
G
G
G
S
I
R
I
H
N
A
E
L
Q
R
Y
I
L
A
T
L
---
L
K
E
D
V
K
M
L
S
H
L
L
Q
A
L
D
Y
G
A
P
P
H
G
G
I
A
L
G
L
D
R
L
I
C
L
V
T
G
S
P
S
I
R
D
V
I
A
F
P
K
S
F
R
G
H
D
L
M
S
N
T
P
D
S
V
P
P
E
E
L
K
P
Y
H
--------
44
HHSearch
65.16
24%
-79
- C7 -
3I7F
-
?
A:
[48-543]
-----
E
I
E
E
L
V
P
A
M
A
E
K
T
V
T
I
R
A
R
V
Q
A
V
R
G
K
G
N
M
V
F
L
F
L
R
K
G
I
Y
T
C
Q
A
L
V
M
K
S
E
T
I
S
K
E
F
V
Q
F
C
Q
K
I
S
A
E
S
I
C
D
I
T
G
I
V
K
A
V
--
E
--
K
P
--
I
E
K
--
A
T
Q
Q
D
V
E
I
H
V
T
S
I
A
V
V
S
L
A
E
Y
P
L
P
M
Q
I
E
D
L
T
FP
S
S
V
F
K
K
Q
E
E
D
IAKVKASA
Q
K
Y
V
K
V
S
-
Q
D
T
------
R
L
D
N
R
M
L
D
L
R
T
V
T
N
I
A
I
F
R
I
Q
S
A
C
C
G
L
F
R
E
F
L
T
S
Q
K
-
F
V
E
I
H
T
P
K
L
I
---------------------
A
Y
L
A
Q
S
P
Q
L
Y
K
Q
M
A
I
M
G
D
F
R
K
V
F
E
V
G
P
V
F
R
A
E
N
S
N
T
R
R
H
L
T
E
F
E
G
L
D
I
E
M
E
I
V
E
N
Y
H
E
C
I
D
V
M
E
K
L
F
T
F
I
F
D
E
I
P
K
R
F
P
D
E
L
K
V
I
R
K
Q
Y
P
F
E
D
L
I
Y
R
P
F
L
R
L
T
Y
K
E
A
I
E
M
L
R
A
S
G
E
T
------
I
G
D
---------------------------------------------
Y
D
-------------------------------------
D
F
T
-----------------------------
T
P
Q
E
V
K
L
G
E
L
I
---
K
A
K
Y
-----------
N
T
D
F
Y
I
L
D
K
F
P
A
-----------------------
A
I
R
P
F
Y
T
M
P
D
I
D
-------
D
--
P
N
Y
S
N
S
Y
D
V
F
V
R
G
Q
E
I
T
S
G
A
Q
R
I
H
D
P
E
F
L
M
K
R
C
I
E
K
G
V
D
P
----
A
T
L
K
D
Y
I
E
S
F
R
F
G
S
W
P
H
A
G
C
G
I
G
L
E
R
I
T
M
L
Y
L
G
I
P
N
I
R
K
V
T
L
F
P
R
D
P
I
R
L
N
P
-------------------------
43
HHSearch
64.79
30%
-77
* C7 *
3NEM
1
SYD_THEKO
A:
[1-436]
M
Y
R
T
H
Y
S
S
E
I
T
E
E
L
N
G
Q
K
V
K
V
A
G
W
V
W
E
V
K
D
L
G
G
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
K
K
-
V
D
P
E
L
F
K
L
I
P
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
T
--
P
--
K
---------
A
K
L
G
F
E
I
L
P
E
K
I
V
V
L
N
R
A
E
T
P
L
P
L
D
P
T
G
K
------------------------
V
K
A
E
-
L
D
T
------
R
L
D
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
-
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
--
F
E
E
D
A
F
L
A
Q
S
P
Q
L
Y
K
Q
I
M
M
A
S
G
L
D
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
I
E
D
E
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
E
H
N
A
K
E
L
D
I
L
N
F
E
L
E
E
---
P
K
L
P
F
P
R
V
S
Y
D
K
A
L
E
I
L
G
D
L
G
K
E
I
P
W
---------------------------------------------------
G
E
-------------------------------------
D
I
D
-----------------------------
T
E
G
E
R
L
L
G
K
Y
---
M
M
E
N
-----------
E
N
A
P
L
Y
F
L
Y
Q
Y
P
S
-----------------------
E
A
K
P
F
Y
-
I
M
K
Y
D
N
------
K
--
P
E
I
C
R
A
F
D
L
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
----
E
S
F
E
F
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
-------------------------