@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2076: (2015-12-13 )
MIKELITKQKTWEIILLVVSGILIPVILAIIKMKVNSIKYISITDHNILNIDSKGKLQYINKTKIFSNLINHQLTVENKGNMKQAITEIIISQIKKVETHIPDIQLDGGFYEKFQKYLLIGYNNGNIESKVETIRLQVCSVEQNTFCENLIDEIFSDDKIIDSGSVESIFLIDLKKYYSIFDNNKKLSDLKIIALDENGNEIQGFFILVRYDRDEKMFKPHPRGLAGPGVEKLPLIDITKDVTKATAKTHQILEQGANQVGFNILVDRTCILKYKVKIKSGHKVIIDNSNYEVKIRIPEYNQEVGMLEGDFYYFIYDNVVELENHFVYSKQNIKTISPKLVFDKYRTVKEIYK
Atome Classification :
(20 SA)
-------------------------------------------------.........10....-------------....------------20....---....30.--------------.......40.....--...50-........60...---.....70..----.....--.80------........90......---..-100.....-----.-------.110....--...120.......130--..--..------...-140-..-----.....-..-150...-.....----160-.------------.....----------------------.170-----....--....180.-----.----------.....190.......200.......210.......220......---------------------------.----------..230.---......240...---...-.-250....----...260.....------------------------------.-----.------------270.----......280........290.......300.......----------310......-----.320.......330.......340.........350.------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------
M
I
K
E
L
I
TKQK
T
W
E
I
I
-------------
L
L
V
V
------------
S
G
I
L
I
P
---
V
I
L
A
I
I
K
--------------MKVN
S
I
K
Y
I
S
ITDH--
N
I
LNI-DSKG
K
L
Q
Y
I
N
K
T
K
---
I
F
S
N
LIN
H
Q
----
L
T
VEN--KG
N
------
M
K
Q
A
I
T
E
I
I
I
S
Q
I
K
K
V
---
E
T-HIP
D
I
Q
LD-----
G
-------
G
F
Y
E
K
F
Q
K
--
Y
L
L
I
G
YNNGNIE
S
K
V
E
--
T
I
--
R
L
------
Q
V
C
-S---VE-----
Q
N
T
F
C
-
E
N
-
L
-
I
D
E
I
-FSDDK----IID-S------------GS
V
E
S
----------------------
I
F
L
------
I
D
L
K
--
K
Y
Y
S
I
FDN-----N----------KKLS
D
L
K
I
I
A
LDENGN
E
I
Q
G
F
F
I
L
V
R
YDRDEKMFKP--HPRGLA---------------------------G----------PGVEKL---
P
L
IDI
T
K
D
V
T
K
A
---
T
A
K
-
T
-
H
Q
I
L
E
QG----
A
N
QVG
F
N
I
L
VD------------------------------
R
-----
T
------------
C
I
L
K
----
Y
K
V
K
IKS-G
H
K
V
I
I
DNSN
Y
E
V
K
I
RIPEYNQEVGMLEG----------
D
F
Y
Y
F
I
YD
N
-----
V
V
E
L
EN
H
F
V
Y
SKQNIKTIS
P
K
L
--
V
F
D
K
Y
R
T
V
K
E
I
YK------------------------------------------
32
Fugue
76.41
22%
-64
- C3 -
4X7P
8
?
A:
[1-493]
M
K
K
I
F
M
M
V
HELDVNKG
G
M
T
S
S
M
F
N
R
S
K
E
F
Y
D
A
DI
P
A
D
I
V
T
F
D
Y
K
GN
Y
D
E
I
I
K
A
L
K
K
Q
G
K
M
D
R
R
T
-------------
K
M
Y
N
------------
V
F
E
Y
F
K
---
Q
I
S
N
N
K
H
--------------
F
K
S
N
K
L
L
Y
K
H
I
S
E
R
L
K
N
T
I
E
I
E
E
S
K
G
I
S
R
Y
F
D
I
T
T
GTY
I
A
Y
I
R
K
S
K
S
----
E
K
V
I
D
F
F
K
D
N
------
K
R
I
E
R
F
S
F
I
D
N
K
V
H
M
K
---
E
T
F
N
V
D
N
K
V
C
Y
-----
Q
-------
V
F
Y
D
E
-
K
G
--
Y
P
Y
I
S
R
N
I
N
A
N
N
G
A
V
G
--
K
T
--
Y
V
------
L
V
N
-
K
---
K
E
FKN--
N
L
A
L
C
-
V
Y
-
Y
-
L
E
K
L
-
I
K
D
S
K
D
S
I
M
I
C
D
G
P
------------
G
S
F
P
K
----------------------
M
F
N
------
T
N
H
K
N
A
Q
K
Y
G
V
I
H
V
-----
N
HHENFDDTGA
F
K
K
S
E
K
Y
I
I
E
---
N
A
N
K
I
N
G
V
I
V
L
T
E
A
Q
R
L
D
I
L
N
Q
F
--
D
V
E
N
I
F
T
I
S
N
FVKIHNAPKHFQTEK
I
V
G
H
I
S
R
M
V
----------
P
T
K
R
I
D
---
L
L
I
E
V
A
E
L
V
V
K
K
---
D
N
A
V
K
-
F
H
I
Y
G
E
G
----
S
V
K
D
K
I
A
K
M
I
E
------------------------------
D
K
NLER
N
------------
V
F
L
K
GYTT
T
P
Q
K
C
L
E
-
D
F
K
L
V
V
S
T
S
Q
Y
E
--------
G
Q
G
L
S
M
I
E
A
M
I
S
K
R
P
V
V
A
F
D
I
K
Y
G
P
S
D
F
-----
I
E
D
N
K
N
G
Y
L
I
E
N
H
N
I
N
D
M
A
D
K
I
L
Q
L
V
N
N
D
V
L
A
A
E
F
G
S
K
A
R
E
N
I
I
E
K
Y
S
T
E
S
I
L
E
K
W
L
N
L
F
N
S-----------------
26
Fugue
63.89
17%
-45
- C2 -
4LK4
-
?
A:
[10-350]
------------------------------------------------R
I
I
N
G
S
N
A
N
S
A
E
W
P
S
I
-------------
V
A
L
V
K
R
GADAYQGQF
C
G
G
S
F
L
G
GR
Y
V
L
T
A
A
H
C
--------------
F
D
S
R
S
A
A
S
V
D
V
I
I
---
G
A
Y
D
L
-
N
N
S
S
Q
G
E
R
I
A
A
Q
K
---
I
Y
R
H
L
---
S
----
Y
S
P
S
N
--
L
L
N
------------
D
I
A
I
V
E
L
A
Q
T
---
S
S
-
L
P
A
I
T
L
A
G
-----
P
-------
A
T
R
T
S
L
P
A
--
L
T
P
L
T
V
A
G
W
G
I
T
F
-----
T
P
--
I
L
------
Q
E
V
-
D
---
V
D
L
V
---
S
Q
S
L
C
-
Q
I
-
V
-
M
Q
H
G
-
I
S
S
D
P
------
N
-
S
------------
T
N
F
C
A
----------------------
A
R
L
------
T
Q
G
D
--
A
G
G
P
I
V
V
K
-----
T
----------
G
R
-
E
Q
L
G
I
V
S
W
---
G
D
E
Q
G
T
Y
G
V
Y
T
N
V
S
Y
F
R
D
W
I
T
K
--
H
T
N
Q
L
S
---------------------------
Y
----------
D
Q
V
A
N
L
GIR
P
L
G
K
V
S
Q
S
F
T
Y
T
---
N
L
D
-
A
-
N
A
L
T
Y
T
G
NTFS
S
L
P
A
D
F
S
V
L
S
D
------------------------------------
G
------------
C
S
T
K
------
V
T
L
A
T
-
G
-----
E
S
C
S
V
E
V
A
V
D
A
Q
H
Y
R
-------------------------
Q
Y
-----
Q
Y
D
F
E
L
I
F
S
Y
A
G
-
G
S
K
R
A
T
S
R
I
--
Q
L
D
T
---------------------------------------------------
35
Fugue
62.86
12%
-47
- C4 -
2H5E
1
RF3_ECOLI
A:
[3-529]
-----------------------------------------------LS
P
Y
L
Q
E
V
A
K
R
R
T
F
A
I
I
S
H
PDAG
K
T
T
I
T
E
K
V
L
L
F
------------
G
Q
I
T
T
S
---
V
M
Q
F
P
Y
H
D
C
L
V
N
L
L
D
TPGHED
F
S
E
D
T
Y
R
T
L
T
A
V
D
C
--
C
L
M
V
I
-
D
A
A
K
G
V
E
--
D
R
T
R
---
K
L
M
E
V
T
R
L
R
D
T
P
I
L
T
F
M
N
--
K
L
D
------
R
D
I
R
D
P
M
E
L
L
D
E
V
E
N
E
LK
I
G
C
-
A
P
I
T
W
P
I
G
CGKLF
K
-------
G
V
Y
H
L
Y
K
D
--
E
T
Y
L
Y
Q
S
G
K
G
H
T
I
Q
E
V
--
R
I
--
V
K
------
G
L
N
-
N
---
P
D
-----
L
D
A
A
V
G
E
D
-
L
-
A
Q
Q
L
-
R
D
E
L
E
----
L
V
K
-
G
ASNEFD
K
E
L
F
L
A
G
E
I
T
P
----------------------
V
F
F
G
T
ALGN
F
G
V
D
--
H
M
L
D
G
L
V
E
WAPAP
M
----------
P
R
Q
T
D
T
R
T
V
E
A
S
E
D
K
--
F
T
G
F
V
F
K
I
Q
A
N
M
D
P
K
H
R
D
R
V
A
F
M
R
V
V
S
---------------------------
G
----------
K
Y
E
K
G
M
---
K
L
R
Q
V
R
T
A
K
D
V
V
---
I
S
D
-
A
-
L
T
F
M
A
V
E
----
E
A
Y
P
G
D
I
L
G
L
H
NHGTIQIG
D
T
F
T
QG
E
M
M
K
F
T
G
I
P
N
F
APE
L
F
R
-----
R
------------
I
R
L
K
----
D
P
K
Q
L
L
K
-
G
L
V
Q
L
S
E
E
G
A
V
Q
V
F
R
P
I
S
N
N
D
L
I
V
G
A
V
G
V
----------
L
Q
F
D
V
V
V
A
R
-----
L
K
S
E
Y
N
V
E
A
V
Y
E
S
V
N
V
A
T
A
R
W
V
--
E
C
A
D
A
K
K
F
E
E
F
K
R
K
N
ESQ
L
A
L
D
GGD
N
L
A
Y
I
A
TS
M
V
N
L
R
L
A
Q
E
R
Y
PD
V
Q
F
H
QTREH
34
Fugue
56.10
14%
-9
- C1 -
4QIQ
1
XYLE_ECOLI
A:
[7-470]
--------------------------------------------------------
S
Y
I
F
S
I
T
L
-------------
V
A
T
L
------------
G
G
L
L
F
G
---
Y
D
T
A
V
I
S
--------------
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
--
N
L
S
E
S
-
A
A
N
S
L
L
G
F
C
V
A
S
A
---
L
I
G
C
I
I
G
G
A
----
L
G
G
Y
C
--
S
N
R
FG
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
WP-
E
L
-
G
F
T
S
I
N
P
D
-----
N
TVPVYLA
G
Y
V
P
E
F
V
I
--
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
--
P
M
--
Y
I
------
A
E
L
-
A
PAH
I
R
-----
G
K
L
V
S
-
F
N
-
Q
-
F
A
I
I
-
F
G
Q
L
L
----
V
Y
C
-
V
------------
N
Y
F
I
A
R
SGD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
EC
I
P
A
L
------
L
F
L
M
--
L
L
Y
T
V
P
E
S
-----
P
----------
R
W
L
M
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
--
I
F
Q
Q
F
V
---------------------------
G
----------
I
N
V
V
L
Y
---
Y
A
P
E
V
F
K
T
L
G
A
S
---
T
D
I
-
A
L
L
Q
T
I
I
V
G
----
V
I
N
L
T
F
T
V
L
A
I
------------------------------
M
-----
T
V
DKFGRKP
L
Q
I
I
G
A
L
G
----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
----------
P
V
C
W
V
L
L
S
E
I
F
PNA
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
--
T
F
P
M
M
D
K
N
S
W
L
V
A
H
FHNGF
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
KFVPETKGKTL--------
13
PsiBlast_PDB
42.00
29%
-26
- C7 -
4LO5
-
?
B:
[105-186]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
T
Y
E
K
--
Y
E
L
I
D
Y
Q
N
G
S
I
V
N
K
A
E
--
Y
Y
L
P
S
L
------
G
Y
C
-
E
---
V
T
-----
N
A
P
S
P
-
E
S
-
E
-
V
V
K
M
Q
V
A
E
D
G
----
F
I
Q
-
N
------------
G
P
E
E
E
----------------------
I
V
V
------
G
V
I
D
--
P
S
E
N
I
Q
E
I
-----
N
----------
T
A
I
S
D
N
Y
T
Y
N
I
P
G
I
V
N
N
N
P
F
Y
I
L
F
T
V
N
T
T
G
I
Y
K
I
N
A
--
Q
N
N
L
P
S
---------------------------
L
----------
K
I
Y
E
A
I
---
G
S
G
N
R
N
F
Q
S
G
N
L
---
C
D
D
-
D
-
I
K
A
I
N
Y
I
----
T
G
F
D
S
P
N
A
K
S
Y
------------------------------
L
-----
V
------------
V
L
L
N
----
K
D
K
N
Y
Y
I
-
R
V
P
Q
T
S
S
N
I
E
N
Q
I
Q
F
K
R
E
E
G
D
L
R
N
L
M
N
S
S
----------
V
N
I
I
D
N
L
N
S
-----
T
G
A
H
Y
Y
T
R
Q
S
P
D
V
H
D
Y
I
S
Y
E
F
T
--
I
P
G
N
F
N
N
K
D
T
S
N
I
------------------------------------------
12
PsiBlast_PDB
41.92
29%
-28
* C7 *
4LO4
-
?
B:
[105-186]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
T
Y
E
K
--
Y
E
L
I
D
Y
Q
N
G
S
I
V
N
K
A
E
--
Y
Y
L
P
S
L
------
G
Y
C
-
E
---
V
T
-----
N
A
P
S
P
-
E
S
-
E
-
V
V
K
M
Q
V
A
E
D
G
----
F
I
Q
-
N
------------
G
P
E
E
E
----------------------
I
V
V
------
G
V
I
D
--
P
S
E
N
I
Q
E
I
-----
N
----------
T
A
I
S
D
N
Y
T
Y
N
I
P
G
I
V
N
N
N
P
F
Y
I
L
F
T
V
N
T
T
G
I
Y
K
I
N
A
--
Q
N
N
L
P
S
---------------------------
L
----------
K
I
Y
E
A
I
---
G
S
G
N
R
N
F
Q
S
G
N
L
---
C
D
D
-
D
-
I
K
A
I
N
Y
I
----
T
G
F
D
S
P
N
A
K
S
Y
------------------------------
L
-----
V
------------
V
L
L
N
----
K
D
K
N
Y
Y
I
-
R
V
P
Q
T
S
S
N
I
E
N
Q
I
Q
F
K
R
E
E
G
D
L
R
N
L
M
N
S
S
----------
V
N
I
I
D
N
L
N
S
-----
T
G
A
H
Y
Y
T
R
Q
S
P
D
V
H
D
Y
I
S
Y
E
F
T
--
I
P
G
N
F
N
N
K
D
T
S
N
I
------------------------------------------
14
PsiBlast_PDB
41.58
29%
-27
- C7 -
4LO6
-
?
B:
[105-186]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
T
Y
E
K
--
Y
E
L
I
D
Y
Q
N
G
S
I
V
N
K
A
E
--
Y
Y
L
P
S
L
------
G
Y
C
-
E
---
V
T
-----
N
A
P
S
P
-
E
S
-
E
-
V
V
K
M
Q
V
A
E
D
G
----
F
I
Q
-
N
------------
G
P
E
E
E
----------------------
I
V
V
------
G
V
I
D
--
P
S
E
N
I
Q
E
I
-----
N
----------
T
A
I
S
D
N
Y
T
Y
N
I
P
G
I
V
N
N
N
P
F
Y
I
L
F
T
V
N
T
T
G
I
Y
K
I
N
A
--
Q
N
N
L
P
S
---------------------------
L
----------
K
I
Y
E
A
I
---
G
S
G
N
R
N
F
Q
S
G
N
L
---
C
D
D
-
D
-
I
K
A
I
N
Y
I
----
T
G
F
D
S
P
N
A
K
S
Y
------------------------------
L
-----
V
------------
V
L
L
N
----
K
D
K
N
Y
Y
I
-
R
V
P
Q
T
S
S
N
I
E
N
Q
I
Q
F
K
R
E
E
G
D
L
R
N
L
M
N
S
S
----------
V
N
I
I
D
N
L
N
S
-----
T
G
A
H
Y
Y
T
R
Q
S
P
D
V
H
D
Y
I
S
Y
E
F
T
--
I
P
G
N
F
N
N
K
D
T
S
N
I
------------------------------------------
15
PsiBlast_PDB
39.46
29%
-20
- C7 -
3WIN
-
?
E:
[115-196]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
T
Y
E
K
--
Y
E
L
I
D
Y
Q
N
G
S
I
V
N
K
A
E
--
Y
Y
LP
S
L
------
G
Y
C
-
E
---
V
T
-----
N
A
P
S
P
-
E
S
E
V
-
V
K
T
Q
-
V
A
E
D
G
----
F
I
Q
-
N
------------
G
P
E
E
E
----------------------
I
V
V
------
G
V
I
D
--
P
S
E
N
I
Q
E
I
-----
N
----------
T
A
I
S
D
N
Y
T
Y
N
I
P
G
I
V
N
N
N
P
F
Y
I
L
F
T
V
N
T
T
G
I
Y
K
I
N
A
--
Q
N
N
L
P
S
---------------------------
L
----------
K
I
Y
E
A
I
---
G
S
G
N
R
N
F
Q
S
G
N
L
---
C
D
D
-
D
-
I
K
A
I
N
Y
I
----
T
G
F
D
S
P
N
A
K
S
Y
------------------------------
L
-----
V
------------
V
L
L
N
----
K
D
K
N
Y
Y
I
-
R
V
P
Q
T
S
S
N
I
E
N
Q
I
K
F
K
R
E
E
G
D
L
R
N
L
M
N
S
S
----------
V
N
I
I
D
N
L
N
S
-----
T
G
A
H
Y
Y
T
R
Q
S
P
D
V
H
D
Y
I
S
Y
E
F
T
--
I
P
G
N
F
N
N
K
D
T
S
N
I
------------------------------------------
25
HHSearch
38.27
15%
20
- C5 -
1GP6
1
LDOX_ARATH
A:
[20-85]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
Y
I
R
--
P
K
E
E
L
E
---------------------------
S
IND
V
F
L
E
E
K
K
E
D
G
P
Q
V
---
P
T
I
D
L
K
N
I
E
S
D
D
E
K
I
R
E
N
-
C
-
I
E
E
L
K
K
A
----
S
L
D
W
G
V
M
H
L
I
N
------------------------------
H
-----
G
------------
I
P
A
D
----
L
M
E
R
V
K
K
-
A
G
E
E
F
F
S
L
S
V
E
E
K
E
K
Y
A
N
D
Q
A
T
G
K
I
Q
G
Y
G
----------
S
K
L
A
N
N
A
S
G
-----
Q
L
E
W
E
D
Y
F
F
H
L
A
Y
P
E
E
K
R
D
L
S
I
--
W
P
K
T
P
S
D
Y
I
E
A
T
S
------------------------------------------
5
PsiBlast_PDB
37.83
33%
12
- C7 -
4EN6
3
?
B:
[104-167]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
T
Y
E
K
--
Y
E
L
I
N
Y
Q
N
G
N
I
D
D
K
A
E
Y
Y
L
P
--
S
L
------
G
K
C
-
E
---
V
S
DAPSP
Q
A
P
V
V
-
E
T
-
P
-
V
D
Q
-----
D
G
----
F
I
Q
-
T
------------
G
P
N
E
N
----------------------
I
I
V
------
G
V
I
N
--
P
S
E
N
I
E
E
I
-----
S
----------
T
P
I
P
D
D
Y
T
Y
N
I
P
T
S
I
Q
N
N
A
C
Y
V
L
F
K
V
N
T
T
G
V
Y
K
I
T
T
--
K
N
N
L
P
P
---------------------------
L
----------
I
I
Y
E
A
I
---
G
S
S
N
R
N
M
N
S
N
N
L
---
S
N
D
-
N
-
I
K
A
I
K
Y
I
----
T
G
L
N
R
S
D
A
K
S
Y
------------------------------
L
-----
I
------------
V
S
L
F
----
K
D
K
N
Y
Y
I
-
R
I
P
Q
I
S
S
S
T
T
S
Q
L
I
F
K
R
E
L
G
N
I
S
D
L
A
D
S
T
----------
V
N
I
L
D
N
L
N
T
-----
S
G
T
H
Y
Y
T
R
Q
S
P
D
V
G
N
Y
I
S
Y
Q
L
T
--
I
P
G
D
F
N
N
I
A
S
S
I
F
------------------------------------------
7
PsiBlast_PDB
37.55
33%
15
- C7 -
4EN8
3
?
B:
[104-167]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
T
Y
E
K
--
Y
E
L
I
N
Y
Q
N
G
N
I
D
D
K
A
E
Y
Y
L
P
--
S
L
------
G
K
C
-
E
---
V
S
DAPSP
Q
A
P
V
V
-
E
T
-
P
-
V
D
Q
-----
D
G
----
F
I
Q
-
T
------------
G
P
N
E
N
----------------------
I
I
V
------
G
V
I
N
--
P
S
E
N
I
E
E
I
-----
S
----------
T
P
I
P
D
D
Y
T
Y
N
I
P
T
S
I
Q
N
N
A
C
Y
V
L
F
K
V
N
T
T
G
V
Y
K
I
T
T
--
K
N
N
L
P
P
---------------------------
L
----------
I
I
Y
E
A
I
---
G
S
S
N
R
N
M
N
S
N
N
L
---
S
N
D
-
N
-
I
K
A
I
K
Y
I
----
T
G
L
N
R
S
D
A
K
S
Y
------------------------------
L
-----
I
------------
V
S
L
F
----
K
D
K
N
Y
Y
I
-
R
I
P
Q
I
S
S
S
T
T
S
Q
L
I
F
K
R
E
L
G
N
I
S
D
L
A
D
S
T
----------
V
N
I
L
D
N
L
N
T
-----
S
G
T
H
Y
Y
T
R
Q
S
P
D
V
G
N
Y
I
S
Y
Q
L
T
--
I
P
G
D
F
N
N
I
A
S
S
I
F
------------------------------------------
6
PsiBlast_PDB
37.47
33%
15
- C7 -
4EN7
3
?
B:
[104-167]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
T
Y
E
K
--
Y
E
L
I
N
Y
Q
N
G
N
I
D
D
K
A
E
Y
Y
L
P
--
S
L
------
G
K
C
-
E
---
V
S
DAPSP
Q
A
P
V
V
-
E
T
-
P
-
V
D
Q
-----
D
G
----
F
I
Q
-
T
------------
G
P
N
E
N
----------------------
I
I
V
------
G
V
I
N
--
P
S
E
N
I
E
E
I
-----
S
----------
T
P
I
P
D
D
Y
T
Y
N
I
P
T
S
I
Q
N
N
A
C
Y
V
L
F
K
V
N
T
T
G
V
Y
K
I
T
T
--
K
N
N
L
P
P
---------------------------
L
----------
I
I
Y
E
A
I
---
G
S
S
N
R
N
M
N
S
N
N
L
---
S
N
D
-
N
-
I
K
A
I
K
Y
I
----
T
G
L
N
R
S
D
A
K
S
Y
------------------------------
L
-----
I
------------
V
S
L
F
----
K
D
K
N
Y
Y
I
-
R
I
P
Q
I
S
S
S
T
T
S
Q
L
I
F
K
R
E
L
G
N
I
S
D
L
A
D
S
T
----------
V
N
I
L
D
N
L
N
T
-----
S
G
T
H
Y
Y
T
R
Q
S
P
D
V
G
N
Y
I
S
Y
Q
L
T
--
I
P
G
D
F
N
N
I
A
S
S
I
F
------------------------------------------
3
PsiBlast_PDB
36.56
33%
20
- C7 -
2ZOE
-
?
B:
[104-167]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
T
Y
E
K
--
Y
E
L
I
N
Y
Q
N
G
N
I
D
D
K
A
E
Y
Y
L
P
--
S
L
------
G
K
C
-
E
---
V
S
DAPSP
Q
A
P
V
V
-
E
T
-
P
-
V
D
Q
-----
D
G
----
F
I
Q
-
T
------------
G
P
N
E
N
----------------------
I
I
V
------
G
V
I
N
--
P
S
E
N
I
E
E
I
-----
S
----------
T
P
I
P
D
D
Y
T
Y
N
I
P
T
S
I
Q
N
N
A
C
Y
V
L
F
K
V
N
T
T
G
V
Y
K
I
T
T
--
K
N
N
L
P
P
---------------------------
L
----------
I
I
Y
E
A
I
---
G
S
S
N
R
N
M
N
S
N
N
L
---
S
N
D
-
N
-
I
K
A
I
K
Y
I
----
T
G
L
N
R
S
D
A
K
S
Y
------------------------------
L
-----
I
------------
V
S
L
F
----
K
D
K
N
Y
Y
I
-
R
I
P
Q
I
S
S
S
T
T
S
Q
L
I
F
K
R
E
L
G
N
I
S
D
L
A
D
S
T
----------
V
N
I
L
D
N
L
N
T
-----
S
G
T
H
Y
Y
T
R
Q
S
P
D
V
G
N
Y
I
S
Y
Q
L
T
--
I
P
G
D
F
N
N
I
A
S
S
I
F
------------------------------------------
8
PsiBlast_PDB
36.17
33%
17
- C7 -
4EN9
4
?
B:
[104-167]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
T
Y
E
K
--
Y
E
L
I
N
Y
Q
N
G
N
I
D
D
K
A
E
Y
Y
L
P
--
S
L
------
G
K
C
-
E
---
V
S
DAPSP
Q
A
P
V
V
-
E
T
-
P
-
V
D
Q
-----
D
G
----
F
I
Q
-
T
------------
G
P
N
E
N
----------------------
I
I
V
------
G
V
I
N
--
P
S
E
N
I
E
E
I
-----
S
----------
T
P
I
P
D
D
Y
T
Y
N
I
P
T
S
I
Q
N
N
A
C
Y
V
L
F
K
V
N
T
T
G
V
Y
K
I
T
T
--
K
N
N
L
P
P
---------------------------
L
----------
I
I
Y
E
A
I
---
G
S
S
N
R
N
M
N
S
N
N
L
---
S
N
D
-
N
-
I
K
A
I
K
Y
I
----
T
G
L
N
R
S
D
A
K
S
Y
------------------------------
L
-----
I
------------
V
S
L
F
----
K
D
K
N
Y
Y
I
-
R
I
P
Q
I
S
S
S
T
T
S
Q
L
I
F
K
R
E
L
G
N
I
S
D
L
A
D
S
T
----------
V
N
I
L
D
N
L
N
T
-----
S
G
T
H
Y
Y
T
R
Q
S
P
D
V
G
N
Y
I
S
Y
Q
L
T
--
I
P
G
D
F
N
N
I
A
S
S
I
F
------------------------------------------
1
PsiBlast_PDB
35.69
27%
-14
- C5 -
5A1U
-
?
H:
[58-135]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
P
M
E
K
LY
M
V
L
I
T
T
K
N
S
N
I
L
E
D
L
E
--
T
L
--
R
L
FSRVIP
E
Y
C
R
A
---
L
E
-----
E
N
E
I
S
-
E
H
-
C
-
F
D
L
I
-
F
A
F
D
E
----
I
V
A
-
L
------------
G
Y
R
E
N
----------------------
V
N
L
------
A
Q
I
R
--
T
F
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
35.25
27%
-14
- C5 -
5A1V
-
?
H:
[58-135]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
P
M
E
K
LY
M
V
L
I
T
T
K
N
S
N
I
L
E
D
L
E
--
T
L
--
R
L
FSRVIP
E
Y
C
R
A
---
L
E
-----
E
N
E
I
S
-
E
H
-
C
-
F
D
L
I
-
F
A
F
D
E
----
I
V
A
-
L
------------
G
Y
R
E
N
----------------------
V
N
L
------
A
Q
I
R
--
T
F
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
34.21
33%
95
- C7 -
2ZS6
-
?
B:
[307-370]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
T
Y
E
K
--
Y
E
L
I
N
Y
Q
N
G
N
I
D
D
K
A
E
Y
Y
L
P
--
S
L
------
G
K
C
-
E
---
V
S
DAPSP
Q
A
P
V
V
-
E
T
-
P
-
V
D
Q
-----
D
G
----
F
I
Q
-
T
------------
G
P
N
E
N
----------------------
I
I
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
32.37
15%
17
- C5 -
2KJG
-
?
A:
[16-71]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-----
K
V
N
F
N
-
L
V
-
M
Q
I
L
D
E
-
I
E
L
D
-----
L
R
G
-
S
------------
D
N
I
K
T
----------------------
S
I
I
------
Y
V
Y
S
--
S
H
L
D
E
I
R
K
-----
N
----------
K
E
F
Y
D
M
I
A
E
I
L
Q
R
Y
Y
K
K
I
G
I
E
N
V
N
Q
L
I
L
T
T
I
K
L
E
H
H
--
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
31.38
37%
71
- C5 -
2AF3
-
PTAS_METTE
C:
[207-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
Y
S
T
--
K
G
S
------
A
K
S
K
L
T
E
A
T
I
A
S
T
K
L
A
---
Q
E
-
L
A
P
D
I
A
I
D
-----
G
-------
E
L
Q
V
D
A
A
I
--
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
--
K
A
--
N
V
------
F
I
F
-
P
---
D
L
-----
N
C
G
N
I
-
A
Y
-
K
-
I
A
Q
R
-
L
A
K
A
E
----
A
Y
G
-
P
------------
I
T
Q
G
L
----------------------
A
K
P
------
I
N
D
L
--
S
R
G
C
S
D
E
D
-----
I
----------
V
G
A
V
A
I
T
C
V
Q
A
A
A
Q
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
29.79
37%
67
- C5 -
2AF4
1
PTAS_METTE
C:
[207-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
Y
S
T
--
K
G
S
------
A
K
S
K
L
T
E
A
T
I
A
S
T
K
L
A
---
Q
E
-
L
A
P
D
I
A
I
D
-----
G
-------
E
L
Q
V
D
A
A
I
--
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
--
K
A
--
N
V
------
F
I
F
-
P
---
D
L
-----
N
C
G
N
I
-
A
Y
-
K
-
I
A
Q
R
-
L
A
K
A
E
----
A
Y
G
-
P
------------
I
T
Q
G
L
----------------------
A
K
P
------
I
N
D
L
--
S
R
G
C
S
D
E
D
-----
I
----------
V
G
A
V
A
I
T
C
V
Q
A
A
A
Q
D
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------