@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2124: (2015-12-13 )
MTQVFQGRSFLAEKDFSREEFEYLIDFSAHLKDLKKRGVPHHYLEGKNIALLFEKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGKKESTEDTAKVLGRMFDGIEFRGFSQRMVEELAEFSGVPVWNGLTDEWHPTQMLADYLTIKENFGKLEGITLVYCGDGRNNVANSLLVAGTLMGVNVHIFSPKELFPAEEIVKLAEEYAKESGAHVLVTDNVDEAVKGADVFYTDVWVSMGEEDKFKERVELLQPYQVNMELIKKANNDNLIFLHCLPAFHDTNTVYGKDVAEKFGVKEMEVTDEVFRSKYARHFDQAENRMHTIKAVMAATLGNLFIPKV
Atome Classification :
(39 SA)
.........10........20........30.-....-...40.....-...50........60........70........80------.....------.------..90........100.......110----------.......120.......130.......140.......150.--...----....160.....-..170.......180.......190....-...200.......210.......220.......230......-.-240.......250.-......260--.--......270.......280.......290--..-.....300.......310.......320.......330.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTQVFQG
R
S
F
L
AEKDF
S
R
E
E
F
E
Y
L
I
D
F
S
A
H
L
K
-
D
L
K
K-RGVPHHYLEG-K
N
I
A
L
L
F
EKTSTR
T
R
A
A
F
T
T
A
A
I
DLGAHPEYLGAN------DIQLG------K------KES
T
E
D
T
A
K
V
L
G
R
M
FDGIEFR
G
F
S
Q
----------
R
M
V
E
E
L
A
E
FSGVPVWNGLTDEW
H
P
T
Q
M
L
A
D
Y
L
T
I
K
E
NF-GK--LE
G
----
I
T
L
V
Y
CGDGR
N
N
-
V
A
N
S
L
L
V
A
G
T
L
M
G
V
N
V
H
I
F
S
P
K
ELF
P
A
E
E
-
I
V
K
L
A
E
E
Y
A
K
ESG
A
H
V
L
V
TDN
V
D
E
A
VKGA
D
V
F
Y
T
D
V
W
VSMG
E
-
E
-
D
K
F
K
E
R
V
E
LLQ
P
Y
Q
-
V
N
M
E
L
I
K
KA--N--ND
N
L
I
F
L
H
CLPAFHDTNTV
Y
G
K
D
V
A
E
K
FG--VK-E
M
E
V
T
D
E
V
F
R
S
K
Y
A
R
H
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
A
A
T
L
GNLFIPKV
22
PsiBlast_CBE
98.99
72%
-103
- C8 -
2W37
1
OTCC_LACHI
B:
[25-359]
---
V
F
Q
G
R
S
V
L
A
E
K
D
F
S
A
A
E
L
E
Y
L
I
D
F
G
L
H
L
K
-
A
L
K
K
-
A
G
I
P
H
H
Y
L
E
G
-
K
N
I
A
L
L
F
E
K
S
S
T
R
T
R
S
A
F
T
T
A
S
I
D
L
G
A
H
P
E
Y
L
G
Q
N
------
D
I
Q
L
G
------
K
------
K
E
S
T
S
D
T
A
K
V
L
G
S
M
F
D
G
I
E
F
R
G
F
K
Q
----------
S
D
A
E
I
L
A
R
D
S
G
V
P
V
W
N
G
L
T
D
E
W
H
P
T
Q
M
L
A
D
F
M
T
V
K
E
N
F
-
G
K
--
L
Q
G
----
L
T
L
T
F
M
G
D
G
R
N
N
-
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
I
H
I
V
A
P
K
A
L
F
P
T
E
E
-
T
Q
N
I
A
K
G
F
A
E
K
S
G
A
K
L
V
I
T
D
D
L
D
E
G
L
K
G
S
N
V
V
Y
T
D
V
W
V
S
M
G
E
-
S
-
N
-
W
E
E
R
V
K
E
L
T
P
Y
Q
-
V
N
M
E
A
M
K
K
T
--
G
TP
D
D
Q
L
I
F
M
H
C
L
P
A
F
H
N
T
D
T
Q
Y
G
K
E
I
K
E
K
Y
G
--
I
T
-
E
M
E
V
T
D
E
V
F
T
S
K
Y
A
R
Q
F
E
E
A
E
N
R
M
H
S
I
K
A
M
M
A
A
T
L
G
N
L
F
I
P
R
V
1
PsiBlast_PDB
98.69
72%
-104
- C8 -
2W37
1
OTCC_LACHI
A:
[25-359]
---
V
F
Q
G
R
S
V
L
A
E
K
D
F
S
A
A
E
L
E
Y
L
I
D
F
G
L
H
L
K
-
A
L
K
K
-
A
G
I
P
H
H
Y
L
E
G
-
K
N
I
A
L
L
F
E
K
S
S
T
R
T
R
S
A
F
T
T
A
S
I
D
L
G
A
H
P
E
Y
L
G
Q
N
------
D
I
Q
L
G
------
K
------
K
E
S
T
S
D
T
A
K
V
L
G
S
M
F
D
G
I
E
F
R
G
F
K
Q
----------
S
D
A
E
I
L
A
R
D
S
G
V
P
V
W
N
G
L
T
D
E
W
H
P
T
Q
M
L
A
D
F
M
T
V
K
E
N
F
-
G
K
--
L
Q
G
----
L
T
L
T
F
M
G
D
G
R
N
N
-
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
I
H
I
V
A
P
K
A
L
F
P
T
E
E
-
T
Q
N
I
A
K
G
F
A
E
K
S
G
A
K
L
V
I
T
D
D
L
D
E
G
L
K
G
S
N
V
V
Y
T
D
V
W
V
S
M
G
E
-
S
-
N
-
W
E
E
R
V
K
E
L
T
P
Y
Q
-
V
N
M
E
A
M
K
K
T
--
G
TP
D
D
Q
L
I
F
M
H
C
L
P
A
F
H
N
T
D
T
Q
Y
G
K
E
I
K
E
K
Y
G
--
I
T
-
E
M
E
V
T
D
E
V
F
T
S
K
Y
A
R
Q
F
E
E
A
E
N
R
M
H
S
I
K
A
M
M
A
A
T
L
G
N
L
F
I
P
R
V
21
PsiBlast_CBE
98.32
72%
-100
- C8 -
2W37
1
OTCC_LACHI
C:
[25-359]
---
V
F
Q
G
R
S
V
L
A
E
K
D
F
S
A
A
E
L
E
Y
L
I
D
F
G
L
H
L
K
-
A
L
K
K
-
A
G
I
P
H
H
Y
L
E
G
-
K
N
I
A
L
L
F
E
K
S
S
T
R
T
R
S
A
F
T
T
A
S
I
D
L
G
A
H
P
E
Y
L
G
Q
N
------
D
I
Q
L
G
------
K
------
K
E
S
T
S
D
T
A
K
V
L
G
S
M
F
D
G
I
E
F
R
G
F
K
Q
----------
S
D
A
E
I
L
A
R
D
S
G
V
P
V
W
N
G
L
T
D
E
W
H
P
T
Q
M
L
A
D
F
M
T
V
K
E
N
F
-
G
K
--
L
Q
G
----
L
T
L
T
F
M
G
D
G
R
N
N
-
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
I
H
I
V
A
P
K
A
L
F
P
T
E
E
-
T
Q
N
I
A
K
G
F
A
E
K
S
G
A
K
L
V
I
T
D
D
L
D
E
G
L
K
G
S
N
V
V
Y
T
D
V
W
V
S
M
G
E
-
S
-
N
-
W
E
E
R
V
K
E
L
T
P
Y
Q
-
V
N
M
E
A
M
K
K
T
--
G
TP
D
D
Q
L
I
F
M
H
C
L
P
A
F
H
N
T
D
T
Q
Y
G
K
E
I
K
E
K
Y
G
--
I
T
-
E
M
E
V
T
D
E
V
F
T
S
K
Y
A
R
Q
F
E
E
A
E
N
R
M
H
S
I
K
A
M
M
A
A
T
L
G
N
L
F
I
P
R
V
101
HHSearch
97.73
73%
-101
- C8 -
2W37
1
OTCC_LACHI
A:
[23-359]
-
Q
N
V
F
Q
G
R
S
V
L
A
E
K
D
F
S
A
A
E
L
E
Y
L
I
D
F
G
L
H
L
K
-
A
L
K
K
-
A
G
I
P
H
H
Y
L
E
G
-
K
N
I
A
L
L
F
E
K
S
S
T
R
T
R
S
A
F
T
T
A
S
I
D
L
G
A
H
P
E
Y
L
G
Q
N
------
D
I
Q
L
G
------
K
------
K
E
S
T
S
D
T
A
K
V
L
G
S
M
F
D
G
I
E
F
R
G
F
K
Q
----------
S
D
A
E
I
L
A
R
D
S
G
V
P
V
W
N
G
L
T
D
E
W
H
P
T
Q
M
L
A
D
F
M
T
V
K
E
N
F
-
G
K
--
L
Q
G
----
L
T
L
T
F
M
G
D
G
R
N
N
-
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
I
H
I
V
A
P
K
A
L
F
P
T
E
E
-
T
Q
N
I
A
K
G
F
A
E
K
S
G
A
K
L
V
I
T
D
D
L
D
E
G
L
K
G
S
N
V
V
Y
T
D
V
W
V
S
M
G
E
-
S
-
N
W
-
E
E
R
V
K
E
L
T
P
Y
Q
-
V
N
M
E
A
M
K
K
T
GT
P
--
D
D
Q
L
I
F
M
H
C
L
P
A
F
H
N
T
D
T
Q
Y
G
K
E
I
K
E
K
Y
G
--
I
T
-
E
M
E
V
T
D
E
V
F
T
S
K
Y
A
R
Q
F
E
E
A
E
N
R
M
H
S
I
K
A
M
M
A
A
T
L
G
N
L
F
I
P
R
V
2
PsiBlast_PDB
91.59
55%
-99
- C8 -
3UPD
-
OTC_VIBVU
A:
[5-334]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
27
PsiBlast_CBE
90.96
55%
-98
- C8 -
4JHX
1
OTC_VIBVU
C:
[29-358]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
--------
A
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
28
PsiBlast_CBE
90.74
55%
-100
- C8 -
4JHX
3
OTC_VIBVU
B:
[29-358]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
---------
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
23
PsiBlast_CBE
90.71
55%
-100
- C8 -
4KWT
3
OTC_VIBVU
C:
[29-358]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
-------
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
29
PsiBlast_CBE
90.42
55%
-99
- C8 -
4JFR
3
OTC_VIBVU
C:
[29-358]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
5
PsiBlast_PDB
90.13
55%
-95
- C8 -
4JHX
3
OTC_VIBVU
A:
[29-358]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
24
PsiBlast_CBE
90.09
55%
-99
- C8 -
4KWT
1
OTC_VIBVU
B:
[29-358]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
---------
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
4
PsiBlast_PDB
89.81
55%
-94
- C8 -
4JFR
2
OTC_VIBVU
A:
[29-358]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
32
PsiBlast_CBE
89.60
55%
-94
- C8 -
4H31
12
OTC_VIBVU
B:
[29-357]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
-------
25
PsiBlast_CBE
89.53
55%
-93
- C8 -
4JQO
6
OTC_VIBVU
C:
[29-358]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
30
PsiBlast_CBE
89.47
55%
-95
- C8 -
4JFR
3
OTC_VIBVU
B:
[29-358]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
26
PsiBlast_CBE
89.31
55%
-93
- C8 -
4JQO
6
OTC_VIBVU
B:
[29-358]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
6
PsiBlast_PDB
89.25
55%
-95
- C8 -
4JQO
8
OTC_VIBVU
A:
[29-358]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
31
PsiBlast_CBE
89.05
55%
-92
- C8 -
4H31
8
OTC_VIBVU
C:
[29-358]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
3
PsiBlast_PDB
89.00
55%
-95
- C8 -
4H31
14
OTC_VIBVU
A:
[29-357]
----
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
-
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
------
G
S
Q
I
G
------
D
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
----------
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q
G
K
A-
L
A
D
----
I
Q
F
A
Y
L
G
D
A
R
N
N
-
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
-
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
D
E
R
V
A
L
M
K
P
Y
Q
-
V
N
M
N
V
L
K
Q
T
--
G
--
N
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
--
M
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
-------
7
PsiBlast_PDB
86.76
52%
-98
- C8 -
1DXH
3
OTCC_PSEAE
A:
[4-335]
----
M
H
N
R
N
L
L
S
L
M
H
H
S
T
R
E
L
R
Y
L
L
D
L
S
R
D
L
K
-
R
A
K
Y
-
T
G
T
E
Q
Q
H
L
K
R
-
K
N
I
A
L
I
F
E
K
T
S
T
R
T
R
C
A
F
E
V
A
A
Y
D
Q
G
A
N
V
T
Y
I
D
P
N
------
S
S
Q
I
G
------
H
------
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
A
I
E
Y
R
G
F
K
Q
----------
E
I
V
E
E
L
A
K
F
A
G
V
P
V
F
N
G
L
T
D
E
Y
H
P
T
Q
M
L
A
D
V
L
T
M
R
E
H
S
-
D
K
P-
L
H
D
----
I
S
Y
A
Y
L
G
D
A
R
N
N
-
M
G
N
S
L
L
L
I
G
A
K
L
G
M
D
V
R
I
A
A
P
K
A
L
W
P
H
D
E
-
F
V
A
Q
C
K
K
F
A
E
E
S
G
A
K
L
T
L
T
E
D
P
K
E
A
V
K
G
V
D
F
V
H
T
D
V
W
V
S
M
G
E
-
P
V
E
A
W
G
E
R
I
K
E
L
L
P
Y
Q
-
V
N
M
E
I
M
K
A
T
--
G
--
N
P
R
A
K
F
M
H
C
L
P
A
F
H
N
S
E
T
K
V
G
K
Q
I
A
E
Q
Y
P
NL
A
N
-
G
I
E
V
T
E
D
V
F
E
S
P
Y
N
I
A
F
E
Q
A
E
N
R
M
H
T
I
K
A
I
L
V
S
T
L
A
D
I
-----
34
PsiBlast_CBE
85.96
52%
-92
- C8 -
1DUV
2
OTC1_ECOLI
H:
[3-331]
----
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
-
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
------
G
S
Q
I
G
------
H
------
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
----------
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P
G
K
A-
F
N
E
----
M
T
L
V
Y
A
G
D
A
R
N
N
-
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
-
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
A
E
R
I
A
L
L
R
E
Y
Q
-
V
N
S
K
M
M
Q
L
T
--
G
--
N
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
--
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
S
K
------
10
PsiBlast_PDB
85.39
52%
-94
- C8 -
1DUV
3
OTC1_ECOLI
G:
[3-331]
----
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
-
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
------
G
S
Q
I
G
------
H
------
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
----------
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P
G
K
A-
F
N
E
----
M
T
L
V
Y
A
G
D
A
R
N
N
-
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
-
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
A
E
R
I
A
L
L
R
E
Y
Q
-
V
N
S
K
M
M
Q
L
T
--
G
--
N
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
--
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
S
K
------
33
PsiBlast_CBE
85.36
52%
-91
- C8 -
1DUV
2
OTC1_ECOLI
I:
[3-331]
----
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
-
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
------
G
S
Q
I
G
------
H
------
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
----------
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P
G
K
A-
F
N
E
----
M
T
L
V
Y
A
G
D
A
R
N
N
-
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
-
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
A
E
R
I
A
L
L
R
E
Y
Q
-
V
N
S
K
M
M
Q
L
T
--
G
--
N
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
--
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
S
K
------
105
HHSearch
80.66
42%
-95
- C8 -
1OTH
1
OTC_HUMAN
A:
[2-314]
--
V
Q
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
-
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
------
D
I
H
L
G
------
V
------
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
----------
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
-
S
S
--
L
K
G
----
L
T
L
S
W
I
G
D
G
-
N
N
-
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
-
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
K
K
R
L
Q
A
F
Q
G
Y
Q
-
V
T
M
K
T
A
K
V
A
-----
A
S
D
W
T
F
L
H
C
L
P
R
K
---------------------
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
S
P
Q
L
Q
19
PsiBlast_PDB
80.00
41%
-95
- C8 -
1EP9
1
OTC_HUMAN
A:
[4-309]
----
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
------
D
I
H
L
G
------
V
------
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
----------
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
-
S
S
--
L
K
G
----
L
T
L
S
W
I
G
D
G
-
N
N
-
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
-
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
K
K
R
L
Q
A
F
Q
G
Y
Q
-
V
T
M
K
T
A
K
V
A
--
A
--
S
D
-
W
T
F
L
H
C
L
P
R
--------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
S
P
Q
L
Q
17
PsiBlast_PDB
79.97
41%
-95
- C8 -
1OTH
1
OTC_HUMAN
A:
[4-309]
----
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
------
D
I
H
L
G
------
V
------
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
----------
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
-
S
S
--
L
K
G
----
L
T
L
S
W
I
G
D
G
-
N
N
-
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
-
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
K
K
R
L
Q
A
F
Q
G
Y
Q
-
V
T
M
K
T
A
K
V
A
--
A
--
S
D
-
W
T
F
L
H
C
L
P
R
--------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
S
P
Q
L
Q
18
PsiBlast_PDB
79.93
41%
-95
- C8 -
1C9Y
2
OTC_HUMAN
A:
[4-309]
----
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
------
D
I
H
L
G
------
V
------
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
----------
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
-
S
S
--
L
K
G
----
L
T
L
S
W
I
G
D
G
-
N
N
-
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
-
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
K
K
R
L
Q
A
F
Q
G
Y
Q
-
V
T
M
K
T
A
K
V
A
--
A
--
S
D
-
W
T
F
L
H
C
L
P
R
--------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
S
P
Q
L
Q
43
PsiBlast_CBE
79.63
41%
-97
- C8 -
1FVO
1
OTC_HUMAN
B:
[4-309]
----
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
------
D
I
H
L
G
------
V
------
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
----------
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
-
S
S
--
L
K
G
----
L
T
L
S
W
I
G
D
G
-
N
N
-
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
-
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
K
K
R
L
Q
A
F
Q
G
Y
Q
-
V
T
M
K
T
A
K
V
A
--
A
--
S
D
-
W
T
F
L
H
C
L
P
R
--------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
S
P
Q
L
Q
20
PsiBlast_PDB
79.49
41%
-94
- C8 -
1FVO
1
OTC_HUMAN
A:
[4-309]
----
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
------
D
I
H
L
G
------
V
------
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
----------
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
-
S
S
--
L
K
G
----
L
T
L
S
W
I
G
D
G
-
N
N
-
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
-
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
K
K
R
L
Q
A
F
Q
G
Y
Q
-
V
T
M
K
T
A
K
V
A
--
A
--
S
D
-
W
T
F
L
H
C
L
P
R
--------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
S
P
Q
L
Q
45
PsiBlast_CBE
78.57
41%
-98
- C8 -
4NF2
4
OTC_BACAN
C:
[36-335]
-------
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-
K
N
K
Q
-
E
P
L
----
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
------
E
M
Q
M
Q
------
R
------
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
----------
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
-
N
T
--
F
K
G
----
I
K
L
A
Y
V
G
D
G
-
N
N
-
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
-
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
-
G
E
-
E
E
K
Y
T
L
F
Q
P
Y
Q
-
I
N
K
E
L
V
K
H
A
--
K
--
Q
-
T
Y
H
F
L
H
C
L
P
A
H
-------------------
R
-
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
------
47
PsiBlast_CBE
78.44
41%
-98
- C8 -
4NF2
5
OTC_BACAN
A:
[36-335]
-------
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-
K
N
K
Q
-
E
P
L
----
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
------
E
M
Q
M
Q
------
R
------
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
----------
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
-
N
T
--
F
K
G
----
I
K
L
A
Y
V
G
D
G
-
N
N
-
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
-
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
-
G
E
-
E
E
K
Y
T
L
F
Q
P
Y
Q
-
I
N
K
E
L
V
K
H
A
--
K
--
Q
-
T
Y
H
F
L
H
C
L
P
A
H
-------------------
R
-
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
------
46
PsiBlast_CBE
77.87
41%
-96
- C8 -
4NF2
5
OTC_BACAN
B:
[36-335]
-------
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-
K
N
K
Q
-
E
P
L
----
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
------
E
M
Q
M
Q
------
R
------
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
----------
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
-
N
T
--
F
K
G
----
I
K
L
A
Y
V
G
D
G
-
N
N
-
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
-
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
-
G
E
-
E
E
K
Y
T
L
F
Q
P
Y
Q
-
I
N
K
E
L
V
K
H
A
--
K
--
Q
-
T
Y
H
F
L
H
C
L
P
A
H
-------------------
R
-
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
------
53
PsiBlast_CBE
75.14
38%
-86
- C8 -
2I6U
5
OTC_MYCTU
B:
[3-300]
-------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
----
E
L
K
K
-
D
P
V
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
------
S
T
Q
L
G
------
R
------
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
----------
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
-
G
A
--
L
R
G
----
L
R
L
S
Y
F
G
D
G
A
N
N
-
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
-
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
-
N
D
G
L
D
R
V
K
P
F
R
P
F
Q
-
L
N
S
R
L
L
A
L
A
--
D
--
S
D
A
I
V
-
L
H
C
L
P
A
H
-------------------
R
-
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
-----
52
PsiBlast_CBE
74.74
38%
-87
- C8 -
2I6U
5
OTC_MYCTU
C:
[3-300]
-------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
----
E
L
K
K
-
D
P
V
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
------
S
T
Q
L
G
------
R
------
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
----------
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
-
G
A
--
L
R
G
----
L
R
L
S
Y
F
G
D
G
A
N
N
-
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
-
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
-
N
D
G
L
D
R
V
K
P
F
R
P
F
Q
-
L
N
S
R
L
L
A
L
A
--
D
--
S
D
A
I
V
-
L
H
C
L
P
A
H
-------------------
R
-
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
-----
107
HHSearch
74.64
39%
-88
- C8 -
2I6U
5
OTC_MYCTU
A:
[2-306]
------
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
-
K
D
P
V
-
S
--
R
R
P
L
Q
G
P
-
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
------
S
T
Q
L
G
------
R
------
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
----------
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
-
G
A
--
L
R
G
----
L
R
L
S
Y
F
G
D
G
A
N
N
-
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
-
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
-
N
D
G
L
D
R
V
K
P
F
R
P
F
Q
-
L
N
S
R
L
L
A
L
A
-----
D
S
D
A
I
V
L
H
C
L
P
A
H
R
--------------------
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
-----
54
PsiBlast_CBE
74.13
38%
-85
- C8 -
2I6U
5
OTC_MYCTU
A:
[3-300]
-------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
----
E
L
K
K
-
D
P
V
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
------
S
T
Q
L
G
------
R
------
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
----------
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
-
G
A
--
L
R
G
----
L
R
L
S
Y
F
G
D
G
A
N
N
-
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
-
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
-
N
D
G
L
D
R
V
K
P
F
R
P
F
Q
-
L
N
S
R
L
L
A
L
A
--
D
--
S
D
A
I
V
-
L
H
C
L
P
A
H
-------------------
R
-
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
-----
90
PsiBlast_CBE
67.29
31%
-72
- C8 -
3M5C
2
AOTC_XANCP
A:
[24-354]
-------
K
H
F
L
N
T
Q
D
W
S
R
A
E
L
D
A
L
L
T
Q
A
A
-----
L
F
K
-
R
N
K
L
G
S
E
L
K
G
-
K
S
I
A
L
V
F
F
N
P
S
M
R
T
R
T
S
F
E
L
G
A
F
Q
L
G
G
H
A
V
V
L
Q
P
G
KDAWPI
E
F
N
L
G
------
T
VMDGDT
E
E
H
I
A
E
V
A
R
V
L
G
R
Y
V
D
L
I
G
V
R
A
F
P
K
FVD
W
S
K
D
R
E
D
Q
V
L
K
S
F
A
K
Y
S
P
V
P
V
I
N
M
E
T
I
T
-
H
P
C
Q
E
L
A
H
A
L
A
L
Q
E
H
F
-
G
T
PD
L
R
G
K
K
Y
V
L
T
W
T
Y
H
P
K
P
L
N
T
A
V
A
N
S
A
L
T
I
A
T
R
M
G
M
D
V
T
L
L
C
P
T
P
D
Y
I
L
D
E
R
Y
M
D
W
A
A
Q
N
V
A
E
S
G
G
S
L
Q
V
S
H
D
I
D
S
A
Y
A
G
A
D
V
V
Y
A
K
S
W
G
A
L
P
F
-
F
-
G
N
W
E
P
E
K
P
I
R
D
Q
Y
Q
H
F
I
V
D
E
R
K
M
A
--
L
--
T
N
N
G
V
F
S
H
C
L
P
L
-------------------
R
R
-
N
V
E
A
T
D
A
V
M
D
S
P
N
C
I
A
I
D
E
A
E
N
R
L
H
V
Q
K
A
I
M
A
A
L
V
--------
91
PsiBlast_CBE
67.13
31%
-71
- C8 -
3M5D
2
AOTC_XANCP
A:
[24-354]
-------
K
H
F
L
N
T
Q
D
W
S
R
A
E
L
D
A
L
L
T
Q
A
A
-----
L
F
K
-
R
N
K
L
G
S
E
L
K
G
-
K
S
I
A
L
V
F
F
N
P
S
M
R
T
R
T
S
F
E
L
G
A
F
Q
L
G
G
H
A
V
V
L
Q
P
G
KDA
W
P
I
E
F
N
L
G
TVMDGD
T
------
E
E
H
I
A
E
V
A
R
V
L
G
R
Y
V
D
L
I
G
V
R
A
F
P
K
FVD
W
S
K
D
R
E
D
Q
V
L
K
S
F
A
K
Y
S
P
V
P
V
I
N
M
E
T
I
T
-
H
P
C
Q
E
L
A
H
A
L
A
L
Q
E
H
F
-
G
T
PD
L
R
G
K
K
Y
V
L
T
W
T
Y
H
P
K
P
L
N
T
A
V
A
N
S
A
L
T
I
A
T
R
M
G
M
D
V
T
L
L
C
P
T
P
D
Y
I
L
D
E
R
Y
M
D
W
A
A
Q
N
V
A
E
S
G
G
S
L
Q
V
S
H
D
I
D
S
A
Y
A
G
A
D
V
V
Y
A
K
S
W
G
A
L
P
F
-
F
-
G
N
W
E
P
E
K
P
I
R
D
Q
Y
Q
H
F
I
V
D
E
R
K
M
A
--
L
--
T
N
N
G
V
F
S
H
C
L
P
L
-------------------
R
R
-
N
V
R
A
T
D
A
V
M
D
S
P
N
C
I
A
I
D
E
A
E
N
R
L
H
V
Q
K
A
I
M
A
A
L
V
--------
92
PsiBlast_CBE
66.80
31%
-70
- C8 -
3M4N
2
AOTC_XANCP
A:
[24-354]
-------
K
H
F
L
N
T
Q
D
W
S
R
A
E
L
D
A
L
L
T
Q
A
A
-----
L
F
K
-
R
N
K
L
G
S
E
L
K
G
-
K
S
I
A
L
V
F
F
N
P
S
M
R
T
R
T
S
F
E
L
G
A
F
Q
L
G
G
H
A
V
V
L
Q
P
G
KDAWPI
E
F
N
L
G
TVMDGD
T
------
E
E
H
I
A
E
V
A
R
V
L
G
R
Y
V
D
L
I
G
V
R
A
F
P
K
FVD
W
S
K
D
R
E
D
Q
V
L
K
S
F
A
K
Y
S
P
V
P
V
I
N
M
E
T
I
T
-
H
P
C
Q
E
L
A
H
A
L
A
L
Q
E
H
F
-
G
T
PD
L
R
G
K
K
Y
V
L
T
W
T
Y
H
P
K
P
L
N
T
A
V
A
N
S
A
L
T
I
A
T
R
M
G
M
D
V
T
L
L
C
P
T
P
D
Y
I
L
D
E
R
Y
M
D
W
A
A
Q
N
V
A
E
S
G
G
S
L
Q
V
S
H
D
I
D
S
A
Y
A
G
A
D
V
V
Y
A
K
S
W
G
A
L
P
F
-
F
-
G
N
W
E
P
E
K
P
I
R
D
Q
Y
Q
H
F
I
V
D
E
R
K
M
A
--
L
--
T
N
N
G
V
F
S
H
C
L
P
L
-------------------
R
R
-
N
V
A
A
T
D
A
V
M
D
S
P
N
C
I
A
I
D
E
A
E
N
R
L
H
V
Q
K
A
I
M
A
A
L
V
--------