@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu00100: (2016-06-01 )
MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAIMIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEISQDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKELGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETSSIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERNGMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGKEKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKDYGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF
Atome Classification :
(29 SA)
.........10........20........30........40........50........60........70........80........90..--......----100.--.--.....110.......120.......130.......140.......150.......160.......170....---...180.......190.......200.......210.......220.......230.......240.......250.......260.......270..-.....280.....--..290---........300----.......310........320-....--...330......--.340.......350-.......360.-......370...---....380.......390.---...-----...400.......410.......420.......430.......440.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
I
K
K
C
K
Q
L
L
M
S
L
V
V
L
T
L
A
V
T
C
LAP
M
S
KAKAASDPIDINA
S
A
A
I
M
I
EASS
G
K
I
L
Y
SKNADKRL
P
I
A
S
M
T
K
M
M
T
E
Y
L
L
L
E
A
IDQG
K
V
K
WDQTYT--PDD
Y
V
Y
----
E
ISQ--D--NSLSNVPLRKDG
K
Y
T
V
K
E
L
Y
Q
A
T
A
IYSAN
A
A
A
I
A
I
A
E
I
VAGSE
T
K
F
V
E
K
M
N
A
K
A
K
ELGLT
D
Y
K
F
V
NATGLEN---KDLHGHQPEGTSVNEESEV
S
A
K
D
M
A
V
L
A
D
H
L
ITD
Y
P
E
I
L
E
TSSI
A
K
TKFREGTDDEMDMP
N
W
N
F
M
L
K
G
L
V
S
E
Y
K
K
A
T
VDGLKTGSTDSAGSCFTGTAE-RN
G
M
R
V
I
T
V
V
L
NA--KGNL----HTGR
F
D
E
T
K
K
M
----
F
D
Y
AFDNF-
S
M
K
E
I
YAEGDQV-KG
H
K
--
T
I
SVDKGKEK
E
V
--
G
I
V
TN
K
A
F
SLPVKN-GEEK
N
Y
K
A
K
V
T
-LNKDNLTAPVKK---GTKV
G
K
L
T
A
EYTGDEKDY---GFL-----NSDLAG
V
D
L
V
TKENVEKA
N
W
F
V
L
T
M
R
SI
G
G
F
F
A
G
I
W
G
S
I
V
D
T
VTGWF
61
HHSearch
91.21
38%
-60
- C4 -
1XP4
5
?
A:
[10-378]
-----------------------------------
F
T
I
A
A
K
H
A
I
A
V
E
A
N
T
G
K
I
L
Y
E
K
D
A
T
Q
P
V
E
I
A
S
I
T
K
L
I
T
V
Y
L
V
Y
E
A
L
E
N
G
S
I
T
L
S
T
P
V
D
--
I
S
D
Y
P
Y
----
Q
L
T
T
--
N
--
S
E
A
S
N
I
P
M
E
-
A
R
N
Y
T
V
E
E
L
L
E
A
T
L
V
S
S
A
N
S
A
A
I
A
L
A
E
K
I
A
G
S
E
K
D
F
V
D
M
M
R
A
K
L
L
E
W
G
I
Q
D
A
T
V
V
N
T
T
G
L
N
N
---
E
T
L
G
D
N
I
Y
P
G
S
K
K
D
E
E
N
K
L
S
A
Y
D
V
A
I
V
A
R
N
L
I
K
K
Y
P
Q
V
L
E
I
T
K
K
P
S
S
T
F
A
G
-----
M
T
I
T
S
T
N
Y
M
L
E
G
M
P
A
Y
R
G
--
G
F
D
G
L
K
T
G
T
T
D
K
A
G
E
S
F
V
G
T
T
V
-
E
K
G
M
R
V
I
T
V
V
L
N
A
--
D
H
Q
D
NN--
P
Y
A
R
F
T
A
T
S
S
L
----
M
D
Y
I
S
S
T
F
-
T
L
R
K
I
V
Q
Q
G
D
A
----
Y
Q
D
S
K
A
P
V
Q
D
G
K
E
D
T
V
--
I
A
V
A
P
E
D
I
Y
L
I
E
R
V
G
N
Q
S
-
S
Q
S
V
Q
F
T
P
D
-
S
K
A
I
P
A
P
L
E
A
---
G
T
V
V
G
H
L
T
Y
E
D
-
K
--------
D
L
I
GQGYI
T
T
E
R
P
S
F
E
M
V
A
D
K
K
I
E
-------------------------------
58
HHSearch
87.55
33%
-65
- C4 -
4K91
2
?
A:
[6-344]
-------------------------------
V
P
A
P
P
Q
L
A
A
K
S
Y
V
L
M
D
G
E
S
G
Q
V
L
V
E
N
N
G
D
Q
R
L
P
P
A
S
L
T
K
L
M
T
A
Y
I
A
T
K
E
I
E
A
G
R
I
G
E
N
D
L
V
T
--
V
S
E
H
A
W
----
R
--------
T
G
G
S
R
M
F
I
K
V
G
S
Q
V
S
V
S
D
L
L
H
G
I
I
I
Q
S
G
N
D
A
S
V
A
L
A
E
H
I
A
G
S
E
D
A
F
A
D
M
M
N
T
T
A
Q
K
L
G
L
T
N
S
H
F
M
D
A
T
G
L
P
N
---
P
--
D
H
------------
Y
S
S
A
R
D
M
A
V
L
A
R
A
I
I
Y
G
E
P
S
H
Y
A
I
Y
A
Q
K
E
F
L
W
N
N
-----
I
K
Q
P
N
R
N
L
L
L
W
----
R
D
K
--
T
V
D
G
L
K
T
G
H
T
D
E
A
G
Y
C
L
V
A
S
A
V
-
R
D
G
Q
R
M
I
A
V
V
F
G
T
--
N
S
------
E
Q
A
R
A
A
E
T
Q
K
L
----
L
T
Y
G
F
R
F
F
-
E
S
R
N
F
Y
K
K
G
T
E
----
L
T
--
K
G
L
V
W
K
G
S
E
H
E
V
--
K
A
G
L
A
E
D
L
T
M
T
L
P
R
G
Q
M
Q
-
K
L
Q
A
S
M
V
-
L
-
E
P
Q
L
M
A
P
I
Q
Q
---
G
Q
V
I
G
K
V
E
V
K
L
D
D
--------
K
V
I
---------
R
S
A
D
L
V
A
L
N
A
V
E
E
G
-----------------------------
59
HHSearch
85.35
33%
-59
- C4 -
3ITA
3
DACC_ECOLI
A:
[5-352]
-------------------------------
T
V
E
A
P
S
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
--
V
G
K
D
A
W
----
A
T
G
N
PA
L
--
R
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
Q
T
V
H
G
L
D
A
---
P
--
G
------------
Q
F
S
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
E
Y
A
I
H
K
E
K
E
F
T
F
N
K
-----
I
R
Q
P
N
R
N
R
L
L
W
S
---
S
N
L
--
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
--
K
T
------
D
R
I
R
F
N
E
S
E
K
L
----
L
T
W
G
F
R
F
F
-
E
T
V
T
P
I
K
P
D
A
T
----
F
V
--
T
Q
R
V
W
F
G
D
K
S
E
V
--
N
L
G
A
G
E
A
G
S
V
T
I
P
R
G
Q
L
K
-
N
L
K
A
S
Y
T
-
L
T
E
P
Q
L
T
A
P
L
K
K
---
G
Q
V
V
G
T
I
D
F
Q
L
N
G
--------
K
S
I
---------
E
Q
R
P
L
I
V
M
E
N
V
E
E
G
G
----------------------------
1
PsiBlast_PDB
85.22
37%
-50
- C4 -
1XP4
5
?
A:
[12-378]
-------------------------------------
I
A
A
K
H
A
I
A
V
E
A
N
T
G
K
I
L
Y
E
K
D
A
T
Q
P
V
E
I
A
S
I
T
K
L
I
T
V
Y
L
V
Y
E
A
L
E
N
G
S
I
T
L
S
T
P
V
D
--
I
S
D
Y
P
Y
----
Q
L
T
T
--
N
--
S
E
A
S
N
I
P
M
E
A
R
-
N
Y
T
V
E
E
L
L
E
A
T
L
V
S
S
A
N
S
A
A
I
A
L
A
E
K
I
A
G
S
E
K
D
F
V
D
M
M
R
A
K
L
L
E
W
G
I
Q
D
A
T
V
V
N
T
T
G
L
N
N
---
E
T
L
G
D
N
I
Y
P
G
S
K
K
D
E
E
N
K
L
S
A
Y
D
V
A
I
V
A
R
N
L
I
K
K
Y
P
Q
V
L
E
I
T
K
K
P
S
S
T
F
A
G
M
T
-----
I
T
S
T
N
Y
M
L
E
G
M
P
A
--
Y
R
G
G
F
D
G
L
K
T
G
T
T
D
K
A
G
E
S
F
V
G
T
T
V
-
E
K
G
M
R
V
I
T
V
V
L
N
A
DH
Q
D
N
N
----
P
Y
A
R
F
T
A
T
S
S
L
----
M
D
Y
I
S
S
T
F
-
T
L
R
K
I
V
Q
Q
G
D
A
Y
-
Q
D
S
K
--
A
-
P
V
Q
D
G
K
E
D
T
V
--
I
A
V
A
P
E
D
I
Y
L
I
E
R
V
-
G
N
Q
S
S
Q
S
V
Q
F
T
-
P
D
S
K
A
I
P
A
P
L
E
A
---
G
T
V
V
G
H
L
T
Y
E
----
D
K
D
L
IGQ
G
Y
I
-----
T
T
E
R
P
S
F
E
M
V
A
D
K
K
I
E
-------------------------------
21
PsiBlast_CBE
81.44
33%
-64
- C4 -
4K91
2
?
B:
[9-321]
----------------------------------
P
P
Q
L
A
A
K
S
Y
V
L
M
D
G
E
S
G
Q
V
L
V
E
N
N
G
D
Q
R
L
P
P
A
S
L
T
K
L
M
T
A
Y
I
A
T
K
E
I
E
A
G
R
I
G
E
N
D
L
V
T
--
V
S
E
H
A
W
----
R
T
G
G
--------
S
R
M
F
I
K
V
G
S
Q
V
S
V
S
D
L
L
H
G
I
I
I
Q
S
G
N
D
A
S
V
A
L
A
E
H
I
A
G
S
E
D
A
F
A
D
M
M
N
T
T
A
Q
K
L
G
L
T
N
S
H
F
M
D
A
T
G
L
P
N
---
P
D
H
Y
S
--------------
S
A
R
D
M
A
V
L
A
R
A
I
I
Y
G
E
P
-----
S
H
Y
A
I
Y
A
Q
K
E
F
L
W
N
N
I
K
Q
P
N
R
N
L
L
L
------
W
R
D
K
T
V
D
G
L
K
T
G
H
T
D
E
A
G
Y
C
L
V
A
S
A
V
-
R
D
G
Q
R
M
I
A
V
V
F
G
T
----
N
S
----
E
Q
A
R
A
A
E
T
Q
K
L
----
L
T
Y
G
F
R
F
F
-
E
S
R
N
F
Y
K
K
G
T
E
L
T
K
G
------
L
V
W
K
G
S
E
H
E
V
K
A
G
L
A
E
D
L
T
M
T
L
P
--
R
-
G
Q
M
Q
K
L
Q
A
S
M
V
-
L
-
E
P
Q
L
M
A
P
I
Q
Q
---
G
Q
V
I
G
K
V
---------------------------------------------------------------------
3
PsiBlast_PDB
81.41
32%
-55
- C4 -
3IT9
6
DACC_ECOLI
A:
[11-351]
-------------------------------------
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
A
T
----
G
N
P
A
--
L
--
R
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
-----------
Q
T
V
H
G
L
D
A
P
G
------
Q
F
S
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
-----
E
Y
A
I
H
K
E
K
E
F
T
F
N
K
I
R
Q
P
N
R
N
R
L
L
W
S
-----
S
N
L
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
--
K
T
D
R
----
I
--
R
F
N
E
S
E
K
L
----
L
T
W
G
F
R
F
F
E
T
V
T
P
I
K
P
D
A
T
F
V
-------
T
Q
R
V
W
F
G
D
K
S
E
V
--
N
L
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
-
L
T
E
P
Q
L
T
A
P
L
K
K
---
G
Q
V
V
G
T
I
---------
D
F
---
Q
L
N
-----
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
G
-----------------------------
77
Fugue
80.99
29%
-71
- C4 -
1HD8
-
DACA_ECOLI
A:
[3-356]
-------------------------
L
N
I
K
T
M
I
P
G
V
P
Q
I
D
A
E
S
Y
I
L
I
D
Y
N
S
G
K
V
L
A
E
Q
N
A
D
V
R
R
D
P
A
S
L
T
K
M
M
T
S
Y
V
I
G
Q
A
M
K
A
G
K
F
K
E
T
D
L
V
T
--
I
G
-----------------------
N
L
K
P
G
M
Q
V
P
V
S
Q
L
I
R
D
I
N
L
Q
S
G
N
D
A
C
V
A
M
A
D
F
A
A
G
S
Q
D
A
F
V
G
L
M
N
S
Y
V
N
A
L
G
L
K
N
T
H
F
Q
T
V
H
G
L
D
A
---
D
G
Q
Y
--------------
S
S
A
R
D
M
A
L
I
G
Q
A
L
I
R
D
V
P
N
E
Y
S
I
Y
K
E
K
E
F
T
F
----
N
G
I
R
Q
L
N
R
N
G
L
L
W
------
D
N
S
L
N
V
D
G
I
K
T
G
H
T
D
K
A
G
Y
N
L
V
A
S
A
T
-
E
G
Q
M
R
L
I
S
A
V
M
G
G
--
R
T
F
------
K
G
R
E
A
E
S
K
K
L
----
L
T
W
G
F
R
F
F
-
E
T
V
N
P
L
K
V
G
K
E
F
----
A
--
S
E
P
V
W
F
G
D
S
D
R
A
--
S
L
G
V
D
K
D
V
Y
L
T
I
P
R
-
G
R
M
K
D
L
K
A
S
Y
V
-
L
N
S
S
E
L
H
A
P
L
Q
K
---
N
Q
V
V
G
T
I
N
F
Q
L
D
G
-----------------
K
T
I
E
Q
R
P
L
V
V
L
Q
E
I
P
E
G
N
----------------------------
28
PsiBlast_CBE
80.91
32%
-57
- C4 -
3IT9
3
DACC_ECOLI
C:
[11-351]
-------------------------------------
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
A
T
----
G
N
P
A
--
L
--
R
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
-----------
Q
T
V
H
G
L
D
A
P
G
------
Q
F
S
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
-----
E
Y
A
I
H
K
E
K
E
F
T
F
N
K
I
R
Q
P
N
R
N
R
L
L
W
S
-----
S
N
L
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
--
K
T
D
R
----
I
--
R
F
N
E
S
E
K
L
----
L
T
W
G
F
R
F
F
E
T
V
T
P
I
K
P
D
A
T
F
V
-------
T
Q
R
V
W
F
G
D
K
S
E
V
--
N
L
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
-
L
T
E
P
Q
L
T
A
P
L
K
K
---
G
Q
V
V
G
T
I
---------
D
F
---
Q
L
------
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
G
-----------------------------
2
PsiBlast_PDB
80.07
33%
-63
- C4 -
4K91
2
?
A:
[9-321]
----------------------------------
P
P
Q
L
A
A
K
S
Y
V
L
M
D
G
E
S
G
Q
V
L
V
E
N
N
G
D
Q
R
L
P
P
A
S
L
T
K
L
M
T
A
Y
I
A
T
K
E
I
E
A
G
R
I
G
E
N
D
L
V
T
--
V
S
E
H
A
W
----
R
T
G
G
--------
S
R
M
F
I
K
V
G
S
Q
V
S
V
S
D
L
L
H
G
I
I
I
Q
S
G
N
D
A
S
V
A
L
A
E
H
I
A
G
S
E
D
A
F
A
D
M
M
N
T
T
A
Q
K
L
G
L
T
N
S
H
F
M
D
A
T
G
L
P
N
---
P
D
H
Y
S
--------------
S
A
R
D
M
A
V
L
A
R
A
I
I
Y
G
E
P
-----
S
H
Y
A
I
Y
A
Q
K
E
F
L
W
N
N
I
K
Q
P
N
R
N
L
L
L
------
W
R
D
K
T
V
D
G
L
K
T
G
H
T
D
E
A
G
Y
C
L
V
A
S
A
V
-
R
D
G
Q
R
M
I
A
V
V
F
G
T
----
N
S
----
E
Q
A
R
A
A
E
T
Q
K
L
----
L
T
Y
G
F
R
F
F
-
E
S
R
N
F
Y
K
K
G
T
E
L
T
K
G
------
L
V
W
K
G
S
E
H
E
V
K
A
G
L
A
E
D
L
T
M
T
L
P
--
R
-
G
Q
M
Q
K
L
Q
A
S
M
V
-
L
-
E
P
Q
L
M
A
P
I
Q
Q
---
G
Q
V
I
G
K
V
---------------------------------------------------------------------
4
PsiBlast_PDB
79.72
32%
-55
- C4 -
3ITA
3
DACC_ECOLI
A:
[11-351]
-------------------------------------
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
A
T
----
G
N
P
A
--
L
--
R
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
-----------
Q
T
V
H
G
L
D
A
P
G
------
Q
F
S
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
-----
E
Y
A
I
H
K
E
K
E
F
T
F
N
K
I
R
Q
P
N
R
N
R
L
L
W
S
-----
S
N
L
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
--
K
T
D
R
----
I
--
R
F
N
E
S
E
K
L
----
L
T
W
G
F
R
F
F
E
T
V
T
P
I
K
P
D
A
T
F
V
-------
T
Q
R
V
W
F
G
D
K
S
E
V
--
N
L
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
-
L
T
E
P
Q
L
T
A
P
L
K
K
---
G
Q
V
V
G
T
I
---------
D
F
---
Q
L
N
-----
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
G
-----------------------------
25
PsiBlast_CBE
79.23
32%
-59
- C4 -
3ITA
3
DACC_ECOLI
D:
[11-351]
-------------------------------------
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
VG
K
D
A
-------------------------
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
-----------
Q
T
V
H
G
L
D
A
P
G
------
Q
F
S
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
-----
E
Y
A
I
H
K
E
K
E
F
T
F
N
K
I
R
Q
P
N
R
N
R
L
L
W
S
-----
S
N
L
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
--
K
T
D
R
----
I
--
R
F
N
E
S
E
K
L
----
L
T
W
G
F
R
F
F
E
T
V
T
P
I
K
P
D
A
T
F
V
-------
T
Q
R
V
W
F
G
D
K
S
E
V
--
N
L
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
-
L
T
E
P
Q
L
T
A
P
L
K
K
---
G
Q
V
V
G
T
I
---------
D
F
---
Q
L
N
-----
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
G
-----------------------------
22
PsiBlast_CBE
79.22
32%
-54
- C4 -
3ITB
3
DACC_ECOLI
D:
[11-351]
-------------------------------------
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
A
T
----
G
N
P
A
--
L
--
R
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
-----------
Q
T
V
H
G
L
D
A
P
G
------
Q
F
S
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
-----
E
Y
A
I
H
K
E
K
E
F
T
F
N
K
I
R
Q
P
N
R
N
R
L
L
W
S
-----
S
N
L
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
--
K
T
D
R
----
I
--
R
F
N
E
S
E
K
L
----
L
T
W
G
F
R
F
F
E
T
V
T
P
I
K
P
D
A
T
F
V
-------
T
Q
R
V
W
F
G
D
K
S
E
V
--
N
L
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
-
L
T
E
P
Q
L
T
A
P
L
K
K
---
G
Q
V
V
G
T
I
---------
D
F
---
Q
L
N
-----
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
G
-----------------------------
57
HHSearch
79.12
29%
-63
- C4 -
3MZF
2
DACA_ECOLI
A:
[10-357]
--------------------------------
P
G
V
P
Q
I
D
A
E
S
Y
I
L
I
D
Y
N
S
G
K
V
L
A
E
Q
N
A
D
V
R
R
D
P
A
S
L
T
K
M
M
T
S
Y
V
I
G
Q
A
M
K
A
G
K
F
K
E
T
D
L
V
T
--
I
G
N
D
A
W
----
A
T
G
N
--
P
VF
K
G
S
S
L
M
F
L
K
P
G
M
Q
V
P
V
S
Q
L
I
R
G
I
N
L
Q
S
G
N
D
A
C
V
A
M
A
D
F
A
A
G
S
Q
D
A
F
V
G
L
M
N
S
Y
V
N
A
L
G
L
K
N
T
H
F
Q
T
V
H
G
L
D
A
---
D
--
G
------------
Q
Y
S
S
A
R
D
M
A
L
I
G
Q
A
L
I
R
D
V
P
N
E
Y
S
I
Y
K
E
K
E
F
T
F
N
G
-----
I
R
Q
L
N
R
N
G
L
L
W
D
---
N
S
L
--
N
V
D
G
I
K
T
G
H
T
D
K
A
G
Y
N
L
V
A
S
A
T
-
E
G
Q
M
R
L
I
S
A
V
M
G
G
--
R
T
------
F
K
G
R
E
A
E
S
K
K
L
----
L
T
W
G
F
R
F
F
-
E
T
V
N
P
L
K
V
G
K
E
----
F
A
--
S
E
P
V
W
F
G
D
S
D
R
A
--
S
L
G
V
D
K
D
V
Y
L
T
I
P
R
G
R
M
K
-
D
L
K
A
S
Y
V
-
L
N
S
S
E
L
H
A
P
L
Q
K
---
N
Q
V
V
G
T
I
N
F
Q
L
D
G
--------
K
T
I
---------
E
Q
R
P
L
V
V
L
Q
E
I
P
E
G
N
F
---------------------------
29
PsiBlast_CBE
78.43
32%
-56
- C4 -
3IT9
4
DACC_ECOLI
B:
[11-351]
-------------------------------------
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
A
T
----
G
N
P
A
--
L
--
R
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
-----------
Q
T
V
H
G
L
D
A
P
G
------
Q
F
S
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
-----
E
Y
A
I
H
K
E
K
E
F
T
F
N
K
I
R
Q
P
N
R
N
R
L
L
W
S
-----
S
N
L
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
--
K
T
D
R
----
I
--
R
F
N
E
S
E
K
L
----
L
T
W
G
F
R
F
F
E
T
V
T
P
I
K
P
D
A
T
F
V
-------
T
Q
R
V
W
F
G
D
K
S
E
V
--
N
L
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
-
L
T
E
P
Q
L
T
A
P
L
K
K
---
G
Q
V
V
G
T
I
---------
D
F
---
Q
L
N
-----
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
G
-----------------------------
24
PsiBlast_CBE
78.43
32%
-51
- C4 -
3ITB
3
DACC_ECOLI
B:
[11-351]
-------------------------------------
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
A
T
----
G
N
P
A
--
L
--
R
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
-----------
Q
T
V
H
G
L
D
A
P
G
------
Q
F
S
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
-----
E
Y
A
I
H
K
E
K
E
F
T
F
N
K
I
R
Q
P
N
R
N
R
L
L
W
S
-----
S
N
L
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
--
K
T
D
R
----
I
--
R
F
N
E
S
E
K
L
----
L
T
W
G
F
R
F
F
E
T
V
T
P
I
K
P
D
A
T
F
V
-------
T
Q
R
V
W
F
G
D
K
S
E
V
--
N
L
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
-
L
T
E
P
Q
L
T
A
P
L
K
K
---
G
Q
V
V
G
T
I
---------
D
F
---
Q
L
N
-----
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
G
-----------------------------
23
PsiBlast_CBE
78.39
32%
-54
* C4 *
3ITB
3
DACC_ECOLI
C:
[11-351]
-------------------------------------
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
A
T
----
G
N
P
A
--
L
--
R
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
-----------
Q
T
V
H
G
L
D
A
P
G
------
Q
F
S
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
-----
E
Y
A
I
H
K
E
K
E
F
T
F
N
K
I
R
Q
P
N
R
N
R
L
L
W
S
-----
S
N
L
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
--
K
T
D
R
----
I
--
R
F
N
E
S
E
K
L
----
L
T
W
G
F
R
F
F
E
T
V
T
P
I
K
P
D
A
T
F
V
-------
T
Q
R
V
W
F
G
D
K
S
E
V
--
N
L
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
-
L
T
E
P
Q
L
T
A
P
L
K
K
---
G
Q
V
V
G
T
I
---------
D
F
---
Q
L
N
-----
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
G
-----------------------------
26
PsiBlast_CBE
78.33
32%
-53
- C4 -
3ITA
4
DACC_ECOLI
B:
[11-351]
-------------------------------------
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
A
T
----
G
N
P
A
--
L
--
R
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
-----------
Q
T
V
H
G
L
D
A
P
G
------
Q
F
S
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
-----
E
Y
A
I
H
K
E
K
E
F
T
F
N
K
I
R
Q
P
N
R
N
R
L
L
W
S
-----
S
N
L
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
--
K
T
D
R
----
I
--
R
F
N
E
S
E
K
L
----
L
T
W
G
F
R
F
F
E
T
V
T
P
I
K
P
D
A
T
F
V
-------
T
Q
R
V
W
F
G
D
K
S
E
V
--
N
L
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
-
L
T
E
P
Q
L
T
A
P
L
K
K
---
G
Q
V
V
G
T
I
---------
D
F
---
Q
L
N
-----
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
G
-----------------------------
5
PsiBlast_PDB
78.25
32%
-55
- C4 -
3ITB
4
DACC_ECOLI
A:
[11-351]
-------------------------------------
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
A
T
----
G
N
P
A
--
L
--
R
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
-----------
Q
T
V
H
G
L
D
A
P
G
------
Q
F
S
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
-----
E
Y
A
I
H
K
E
K
E
F
T
F
N
K
I
R
Q
P
N
R
N
R
L
L
W
S
-----
S
N
L
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
--
K
T
D
R
----
I
--
R
F
N
E
S
E
K
L
----
L
T
W
G
F
R
F
F
E
T
V
T
P
I
K
P
D
A
T
F
V
-------
T
Q
R
V
W
F
G
D
K
S
E
V
--
N
L
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
-
L
T
E
P
Q
L
T
A
P
L
K
K
---
G
Q
V
V
G
T
I
---------
D
F
---
Q
L
N
--------
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
G
-----------------------------
60
HHSearch
78.16
30%
-59
- C4 -
3A3J
1
DACA_HAEIN
A:
[3-344]
---------------------------------
T
P
P
Q
I
T
A
Q
T
Y
V
L
M
D
Y
N
S
G
A
I
L
T
A
L
N
P
D
Q
R
Q
Y
P
A
S
L
T
K
M
M
T
S
Y
V
V
G
V
A
L
K
Q
G
K
I
H
N
T
D
M
V
T
--
I
G
E
S
A
W
----
G
R
-
N
--
F
--
P
D
S
S
K
M
F
L
D
L
N
T
Q
V
S
V
A
D
L
N
R
G
V
I
V
V
S
G
N
D
A
T
V
A
L
A
E
H
I
S
G
N
V
P
N
F
V
E
T
M
N
K
Y
V
Q
Q
F
G
L
K
N
T
N
F
T
T
P
H
G
L
D
D
---
P
--
N
Q
------------
Y
S
S
A
R
D
M
A
I
I
G
A
H
I
I
R
D
L
P
E
E
Y
K
I
Y
S
E
K
D
F
T
F
N
K
-----
I
K
Q
P
N
R
N
G
L
L
W
D
---
K
T
I
--
N
V
D
G
M
K
T
G
H
T
S
Q
A
G
Y
N
L
V
A
S
A
T
T
S
N
N
M
R
L
I
S
V
V
M
G
V
--
P
T
------
Y
K
G
R
E
V
E
S
K
K
L
----
L
Q
W
G
F
A
N
F
-
E
T
F
K
T
L
E
A
G
K
E
----
I
S
--
E
Q
R
V
Y
Y
G
D
K
N
S
V
--
K
L
G
A
F
M
D
H
F
I
T
I
P
K
G
K
Q
S
-
E
V
K
A
R
Y
E
-
L
A
D
K
N
L
Q
A
P
L
A
K
---
G
Q
V
I
G
K
V
V
Y
A
L
D
G
--------
K
D
I
---------
A
S
A
N
L
Q
V
M
N
D
V
G
E
------------------------------
27
PsiBlast_CBE
77.95
32%
-53
- C4 -
3IT9
3
DACC_ECOLI
D:
[11-351]
-------------------------------------
V
D
A
R
A
W
I
L
M
D
Y
A
S
G
K
V
L
A
E
G
N
A
D
E
K
L
D
P
A
S
L
T
K
I
M
T
S
Y
V
V
G
Q
A
L
K
A
D
K
I
K
L
T
D
M
V
T
V
G
K
D
A
W
A
T
----
G
N
P
A
--
L
--
R
G
S
S
V
M
F
L
K
P
G
D
Q
V
S
V
A
D
L
N
K
G
V
I
I
Q
S
G
N
D
A
C
I
A
L
A
D
Y
V
A
G
S
Q
E
S
F
I
G
L
M
N
G
Y
A
K
K
L
G
L
T
N
T
T
F
-----------
Q
T
V
H
G
L
D
A
P
G
------
Q
F
S
T
A
R
D
M
A
L
L
G
K
A
L
I
H
D
V
P
E
-----
E
Y
A
I
H
K
E
K
E
F
T
F
N
K
I
R
Q
P
N
R
N
R
L
L
W
S
-----
S
N
L
N
V
D
G
M
K
T
G
T
T
A
G
A
G
Y
N
L
V
A
S
A
T
-
Q
G
D
M
R
L
I
S
V
V
L
G
A
--
K
T
D
R
----
I
--
R
F
N
E
S
E
K
L
----
L
T
W
G
F
R
F
F
E
T
V
T
P
I
K
P
D
A
T
F
V
-------
T
Q
R
V
W
F
G
D
K
S
E
V
--
N
L
G
A
G
E
A
G
S
V
T
I
P
R
-
G
Q
L
K
N
L
K
A
S
Y
T
-
L
T
E
P
Q
L
T
A
P
L
K
K
---
G
Q
V
V
G
T
I
---------
D
F
---
Q
L
N
-----
G
K
S
I
E
Q
R
P
L
I
V
M
E
N
V
E
E
G
-----------------------------
13
PsiBlast_PDB
74.67
31%
-63
- C4 -
3BEB
2
DACA_ECOLI
A:
[15-338]
-------------------------------------
I
D
A
E
S
Y
I
L
I
D
Y
N
S
G
K
V
L
A
E
Q
N
A
D
V
R
R
D
P
A
S
L
T
K
M
M
T
S
Y
V
I
G
Q
A
M
K
A
G
K
F
K
E
T
D
L
V
T
--
I
G
N
D
A
W
ATGN
P
V
F
K
--
G
--
S
S
L
--
M
F
L
K
P
G
M
Q
V
P
V
S
Q
L
I
R
G
I
N
L
Q
S
G
N
D
A
C
V
A
M
A
D
F
A
A
G
S
Q
D
A
F
V
G
L
M
N
S
-----------
Y
V
N
A
L
G
L
K
N
THF
Q
T
V
H
G
L
D
A
D
G
------
Q
Y
S
S
A
R
D
M
A
L
I
G
Q
A
L
I
R
D
V
P
---
N
E
Y
S
I
Y
K
E
K
--
E
F
T
F
N
G
I
R
Q
L
N
R
N
----
G
L
L
W
D
-
N
S
L
N
V
D
G
I
K
T
G
H
T
D
K
A
G
Y
N
L
V
A
S
A
T
-
E
G
Q
M
R
L
I
S
A
V
M
G
----
G
R
T
----
F
K
G
R
E
A
E
S
K
K
L
----
L
T
W
G
F
R
F
F
-
E
T
V
N
P
L
K
V
G
K
E
F
-
A
S
E
-----
P
V
W
F
G
D
S
D
R
A
--
S
L
G
V
D
K
D
V
Y
L
T
I
P
R
-
G
R
M
K
D
L
K
A
S
Y
V
-
L
N
S
S
E
L
H
A
P
L
Q
K
---
N
Q
V
V
G
T
I
N
F
Q
L
D
G
---------------------------------------------------------------
14
PsiBlast_PDB
72.46
31%
-63
- C4 -
3BEC
5
DACA_ECOLI
A:
[15-338]
-------------------------------------
I
D
A
E
S
Y
I
L
I
D
Y
N
S
G
K
V
L
A
E
Q
N
A
D
V
R
R
D
P
A
S
L
T
K
M
M
T
S
Y
V
I
G
Q
A
M
K
A
G
K
F
K
E
T
D
L
V
T
--
I
G
N
D
A
W
ATGN
P
V
F
K
--
G
--
S
S
L
--
M
F
L
K
P
G
M
Q
V
P
V
S
Q
L
I
R
G
I
N
L
Q
S
G
N
D
A
C
V
A
M
A
D
F
A
A
G
S
Q
D
A
F
V
G
L
M
N
S
-----------
Y
V
N
A
L
G
L
K
N
THF
Q
T
V
H
G
L
D
A
D
G
------
Q
Y
S
S
A
R
D
M
A
L
I
G
Q
A
L
I
R
D
V
P
---
N
E
Y
S
I
Y
K
E
K
--
E
F
T
F
N
G
I
R
Q
L
N
R
N
----
G
L
L
W
D
-
N
S
L
N
V
D
G
I
K
T
G
H
T
D
K
A
G
Y
N
L
V
A
S
A
T
-
E
G
Q
M
R
L
I
S
A
V
M
G
----
G
R
T
----
F
K
G
R
E
A
E
S
K
K
L
----
L
T
W
G
F
R
F
F
-
E
T
V
N
P
L
K
V
G
K
E
F
-
A
S
E
-----
P
V
W
F
G
D
S
D
R
A
--
S
L
G
V
D
K
D
V
Y
L
T
I
P
R
-
G
R
M
K
D
L
K
A
S
Y
V
-
L
N
S
S
E
L
H
A
P
L
Q
K
---
N
Q
V
V
G
T
I
N
F
Q
L
D
G
---------------------------------------------------------------
64
HHSearch
69.94
32%
-58
- C4 -
1TVF
4
?
A:
[37-331]
-----------------------------------------
S
A
V
N
V
S
-
Q
T
G
Q
L
L
Y
Q
Y
N
I
D
T
K
W
N
P
A
S
M
T
K
L
M
T
M
Y
L
T
L
E
A
V
N
K
G
Q
L
S
L
D
D
T
V
T
--
M
T
N
K
E
Y
----
I
M
S
T
--
L
--
P
E
L
S
N
T
K
L
Y
P
G
Q
V
W
T
I
A
D
L
L
Q
I
T
V
S
N
S
S
N
A
A
A
L
I
L
A
K
K
V
S
K
N
T
S
D
F
V
D
L
M
N
N
K
A
K
A
I
G
M
K
N
T
H
F
V
N
P
T
G
A
E
N
---
S
R
L
R
S
F
A
P
T
K
Y
K
D
Q
E
R
T
V
T
T
A
R
D
Y
A
I
L
D
L
H
V
I
K
E
T
P
K
I
L
D
F
T
K
Q
L
A
P
T
T
H
-----
A
V
T
Y
Y
T
F
N
F
S
L
E
G
A
K
M
S
L
P
--
G
T
D
G
L
K
T
G
S
S
D
T
A
N
Y
N
H
T
I
T
T
K
-
R
G
K
F
R
I
N
Q
V
I
M
G
A
--
G
D
Y
K
NLGG
E
K
Q
R
N
M
M
G
N
A
L
----
M
E
R
S
F
D
Q
Y
-
K
Y
V
K
I
L
S
K
G
E
Q
----
R
-------
I
N
G
----
K
--
K
Y
Y
V
E
N
D
L
Y
D
V
L
P
S
--------------------------------------------------------------------------------------------------------
63
HHSearch
69.78
30%
-48
- C4 -
3HUN
1
?
A:
[74-405]
------------------------------------------
A
V
N
V
S
-
Q
T
G
Q
L
L
Y
Q
Y
N
I
D
T
K
W
N
P
A
S
M
T
K
L
M
T
M
Y
L
T
L
E
A
V
N
K
G
Q
L
S
L
D
D
T
V
T
--
M
T
N
K
E
Y
----
I
M
S
T
--
L
--
P
E
L
S
N
T
K
L
Y
P
G
Q
V
W
T
I
A
D
L
L
Q
I
T
V
S
N
S
S
N
A
A
A
L
I
L
A
K
K
V
S
K
N
T
S
D
F
V
D
L
M
N
N
K
A
K
A
I
G
M
K
N
T
H
F
V
N
P
T
G
A
E
N
---
S
R
L
R
S
F
A
P
T
K
Y
K
D
Q
E
R
T
V
T
T
A
R
D
Y
A
I
L
D
L
H
V
I
K
E
T
P
K
I
L
D
F
T
K
Q
L
A
P
T
T
H
-----
A
V
T
Y
Y
T
F
N
F
S
L
E
G
A
K
M
S
L
P
--
G
T
D
G
L
K
T
G
S
S
D
T
A
N
Y
N
H
T
I
T
T
K
-
R
G
K
F
R
I
N
Q
V
I
M
G
A
--
G
D
Y
K
NLGG
E
K
Q
R
N
M
M
G
N
A
L
----
M
E
R
S
F
D
Q
Y
-
K
Y
V
K
I
L
S
K
G
E
Q
----
R
-------
I
N
G
K
------
K
Y
Y
V
E
N
D
L
Y
D
V
L
P
S
D
F
S
K
K
D
Y
K
L
V
V
E
---
D
G
K
V
H
A
D
Y
P
R
EFI
N
K
D
Y
G
P
P
T
V
E
V
H
Q
---------------------------------------------------------------
9
PsiBlast_PDB
63.85
33%
-44
- C4 -
1TVF
4
?
A:
[42-312]
-----------------------------------------------
S
Q
T
G
Q
L
L
Y
Q
Y
N
I
D
T
K
W
N
P
A
S
M
T
K
L
M
T
M
Y
L
T
L
E
A
V
N
K
G
Q
L
S
L
D
D
T
V
T
--
M
T
N
K
E
Y
----
I
M
S
T
--
L
--
P
E
L
S
N
T
K
L
Y
P
G
Q
V
W
T
I
A
D
L
L
Q
I
T
V
S
N
S
S
N
A
A
A
L
I
L
A
K
K
V
S
K
N
T
S
D
F
V
D
L
M
N
N
K
A
K
A
I
G
M
K
N
T
H
F
V
N
P
T
G
A
E
N
---
S
R
L
R
S
F
A
P
T
K
Y
K
D
Q
E
R
T
V
T
T
A
R
D
Y
A
I
L
D
L
H
V
I
K
E
T
P
K
I
L
D
F
-----
T
K
Q
L
A
P
T
T
H
A
V
T
Y
Y
T
F
N
F
S
L
E
G
--
A
K
M
S
L
P
G
T
D
G
L
K
T
G
S
S
D
T
A
N
Y
N
H
T
I
T
T
K
-
R
G
K
F
R
I
N
Q
V
I
M
G
A
--
G
D
Y
K
----
N
L
G
G
E
K
Q
R
N
M
M
G
N
A
L
M
E
R
S
F
D
Q
Y
-
K
Y
V
K
I
L
S
K
G
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.82
33%
-39
- C4 -
3HUN
1
?
A:
[78-348]
-----------------------------------------------
S
Q
T
G
Q
L
L
Y
Q
Y
N
I
D
T
K
W
N
P
A
S
M
T
K
L
M
T
M
Y
L
T
L
E
A
V
N
K
G
Q
L
S
L
D
D
T
V
T
--
M
T
N
K
E
Y
----
I
M
S
T
--
L
--
P
E
L
S
N
T
K
L
Y
P
G
Q
V
W
T
I
A
D
L
L
Q
I
T
V
S
N
S
S
N
A
A
A
L
I
L
A
K
K
V
S
K
N
T
S
D
F
V
D
L
M
N
N
K
A
K
A
I
G
M
K
N
T
H
F
V
N
P
T
G
A
E
N
---
S
R
L
R
S
F
A
P
T
K
Y
K
D
Q
E
R
T
V
T
T
A
R
D
Y
A
I
L
D
L
H
V
I
K
E
T
P
K
I
L
D
F
-----
T
K
Q
L
A
P
T
T
H
A
V
T
Y
Y
T
F
N
F
S
L
E
G
--
A
K
M
S
L
P
G
T
D
G
L
K
T
G
S
S
D
T
A
N
Y
N
H
T
I
T
T
K
-
R
G
K
F
R
I
N
Q
V
I
M
G
A
--
G
D
Y
K
----
N
L
G
G
E
K
Q
R
N
M
M
G
N
A
L
M
E
R
S
F
D
Q
Y
-
K
Y
V
K
I
L
S
K
G
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
61.72
33%
-41
- C4 -
1TVF
3
?
B:
[42-312]
-----------------------------------------------
S
Q
T
G
Q
L
L
Y
Q
Y
N
I
D
T
K
W
N
P
A
S
M
T
K
L
M
T
M
Y
L
T
L
E
A
V
N
K
G
Q
L
S
L
D
D
T
V
T
--
M
T
N
K
E
Y
----
I
M
S
T
--
L
--
P
E
L
S
N
T
K
L
Y
P
G
Q
V
W
T
I
A
D
L
L
Q
I
T
V
S
N
S
S
N
A
A
A
L
I
L
A
K
K
V
S
K
N
T
S
D
F
V
D
L
M
N
N
K
A
K
A
I
G
M
K
N
T
H
F
V
N
P
T
G
A
E
N
---
S
R
L
R
S
F
A
P
T
K
Y
K
D
Q
E
R
T
V
T
T
A
R
D
Y
A
I
L
D
L
H
V
I
K
E
T
P
K
I
L
D
F
-----
T
K
Q
L
A
P
T
T
H
A
V
T
Y
Y
T
F
N
F
S
L
E
G
--
A
K
M
S
L
P
G
T
D
G
L
K
T
G
S
S
D
T
A
N
Y
N
H
T
I
T
T
K
-
R
G
K
F
R
I
N
Q
V
I
M
G
A
--
G
D
Y
K
----
N
L
G
G
E
K
Q
R
N
M
M
GNAL
M
E
R
S
F
D
Q
Y
-
K
Y
V
K
I
L
S
K
G
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
60.26
33%
-39
- C4 -
3HUM
1
?
B:
[78-348]
-----------------------------------------------
S
Q
T
G
Q
L
L
Y
Q
Y
N
I
D
T
K
W
N
P
A
S
M
T
K
L
M
T
M
Y
L
T
L
E
A
V
N
K
G
Q
L
S
L
D
D
T
V
T
--
M
T
N
K
E
Y
----
I
M
S
T
--
L
--
P
E
L
S
N
T
K
L
Y
P
G
Q
V
W
T
I
A
D
L
L
Q
I
T
V
S
N
S
S
N
A
A
A
L
I
L
A
K
K
V
S
K
N
T
S
D
F
V
D
L
M
N
N
K
A
K
A
I
G
M
K
N
T
H
F
V
N
P
T
G
A
E
N
---
S
R
L
R
S
F
A
P
T
K
Y
K
D
Q
E
R
T
V
T
T
A
R
D
Y
A
I
L
D
L
H
V
I
K
E
T
P
K
I
L
D
F
-----
T
K
Q
L
A
P
T
T
H
A
V
T
Y
Y
T
F
N
F
S
L
E
G
--
A
K
M
S
L
P
G
T
D
G
L
K
T
G
S
S
D
T
A
N
Y
N
H
T
I
T
T
K
-
R
G
K
F
R
I
N
Q
V
I
M
G
A
--
G
D
Y
K
----
N
L
G
G
E
K
Q
R
N
M
M
GNAL
M
E
R
S
F
D
Q
Y
-
K
Y
V
K
I
L
S
K
G
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
60.14
33%
-38
- C4 -
3HUM
1
?
A:
[78-348]
-----------------------------------------------
S
Q
T
G
Q
L
L
Y
Q
Y
N
I
D
T
K
W
N
P
A
S
M
T
K
L
M
T
M
Y
L
T
L
E
A
V
N
K
G
Q
L
S
L
D
D
T
V
T
--
M
T
N
K
E
Y
----
I
M
S
T
--
L
--
P
E
L
S
N
T
K
L
Y
P
G
Q
V
W
T
I
A
D
L
L
Q
I
T
V
S
N
S
S
N
A
A
A
L
I
L
A
K
K
V
S
K
N
T
S
D
F
V
D
L
M
N
N
K
A
K
A
I
G
M
K
N
T
H
F
V
N
P
T
G
A
E
N
---
S
R
L
R
S
F
A
P
T
K
Y
K
D
Q
E
R
T
V
T
T
A
R
D
Y
A
I
L
D
L
H
V
I
K
E
T
P
K
I
L
D
F
-----
T
K
Q
L
A
P
T
T
H
A
V
T
Y
Y
T
F
N
F
S
L
E
G
--
A
K
M
S
L
P
G
T
D
G
L
K
T
G
S
S
D
T
A
N
Y
N
H
T
I
T
T
K
-
R
G
K
F
R
I
N
Q
V
I
M
G
A
--
G
D
Y
K
----
N
L
G
G
E
K
Q
R
N
M
M
G
N
A
L
M
E
R
S
F
D
Q
Y
-
K
Y
V
K
I
L
S
K
G
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------