@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu00130: (2016-06-01 )
MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGKVEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILLSIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTGSRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDAFKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKKYDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRTVAAILENYQQEDGSVVIPKVLRPYMGNREVMKP
Atome Classification :
(32 SA)
-----------------------------------------------------------------------------------------------........----.----10-.........20--..--.--.--...-.30........40....-------....50........60.....--------.-.-----------------------------.------------------------70.......-.80........90........100---........110......-.-120.......--------------------.130-----.--------------------.......140.......150...-.-...-160.......170.......180.......190.......200.......210...-....220----------..---..--....230.......240...--.--...250.......260.......270.......280.......290--.--.--...----..300.......310.......320.......330.......340.......350.......360.....--..370.--.-----..-----...380.......390.......400.......410.......420.....--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------ML
D
T
K
M
L
R
----
A
----
N
--
F
Q
E
I
K
A
K
L
VHK--GE--D--L--T
D
F
-
D
K
F
E
A
L
D
D
R
R
R
E
L
I
G
K
V
-------
E
E
LKG
K
R
N
E
V
S
Q
Q
V
A
V
L
K
REK--------K-
D
-----------------------------
A
------------------------
D
H
I
I
K
E
M
R
E
-
V
G
E
E
I
K
K
L
D
E
E
L
R
T
V
E
A
E
L
D
T
I
L
----
L
SIPNIPHESVPVGETE-D-D-
N
V
E
V
R
KWG--------------------EKP------S--------------------FAYEPKPHW
D
I
A
D
E
LGI
L
D
F
E
R
A
-A-KVT-GS
R
F
V
F
Y
K
G
L
G
A
R
L
E
R
A
L
Y
N
F
M
L
D
L
HVDEYNYTEVIP
P
Y
MVNRASMTGTGQLPKF
E
-
E
D
A
F
K
I-----------RE---E
D
--
Y
F
L
I
PTAEVPITNM
H
R
D
EIL--S--GDSLP
I
N
Y
A
A
F
S
A
C
F
R
SEAGSAGR
D
T
R
G
L
I
R
Q
HQF
N
K
V
E
L
V
K
FVKP--E--
D
--
S
Y
E
----
E
L
E
K
L
T
N
Q
A
E
R
V
L
Q
L
L
EL
P
Y
R
V
M
S
M
CTGDLGFTAA
K
K
Y
D
I
E
V
W
IPS
Q
D
T
Y
R
E
I
S
SCSN
F
E
A
F
Q
A
RRA
N
I
R
--
F
R
REAK--G-----KP-----
E
H
V
H
TLNGSGL
A
V
G
R
T
V
A
A
I
L
E
N
Y
QQEDG
S
V
V
I
P
K
V
L
R
P
YMGNR--EVMKP--------------
1
PsiBlast_PDB
86.79
59%
-79
- C3 -
2DQ3
1
SYS_AQUAE
A:
[2-424]
------------------------------------------------------------------------------------------------
I
D
I
N
L
I
R
----
E
----
K
--
P
D
Y
V
K
E
R
L
A
T
R
--
D
K
--
E
--
L
--
V
S
L
V
D
K
V
L
E
L
D
K
R
R
R
E
I
I
K
R
L
-------
E
A
L
R
S
E
R
N
K
L
S
K
E
I
G
K
L
K
R
E
G
--------
K
-
D
-----------------------------
T
------------------------
T
E
I
Q
N
R
V
K
E
-
L
K
E
E
I
D
R
L
E
E
E
L
R
K
V
E
E
E
L
K
N
T
L
----
L
W
I
P
N
L
P
H
P
S
V
P
V
G
E
D
E
-
K
-
D
-
N
V
E
V
R
R
W
G
--------------------
E
P
R
------
K
--------------------
F
D
F
E
P
K
P
H
W
E
I
G
E
R
L
G
I
L
D
F
K
R
G
-
A
-
K
L
S
-
G
S
R
F
T
V
I
A
G
W
G
A
R
L
E
R
A
L
I
N
F
M
L
D
L
H
T
K
K
-
G
Y
K
E
I
C
P
P
H
L
V
K
P
E
I
L
I
G
T
G
Q
L
P
K
F
E
-
E
D
L
Y
K
C
-----------
E
R
---
D
N
--
L
Y
L
I
P
T
A
E
V
P
L
T
N
L
Y
R
E
E
I
L
--
K
--
E
E
N
L
P
I
Y
L
T
A
Y
T
P
C
Y
R
R
E
A
G
A
Y
G
K
D
I
R
G
I
I
R
Q
H
Q
F
D
K
V
E
L
V
K
I
V
H
P
--
D
--
T
--
S
Y
D
----
E
L
E
K
L
V
K
D
A
E
E
V
L
Q
L
L
G
L
P
Y
R
V
V
E
L
C
T
G
D
L
G
F
S
A
A
K
T
Y
D
I
E
V
W
F
P
S
Q
N
K
Y
R
E
I
S
S
C
S
N
C
E
D
F
Q
A
R
R
M
N
T
R
--
F
K
D
S
K
T
--
G
-----
K
N
-----
R
F
V
H
T
L
N
G
S
G
L
A
V
G
R
T
L
A
A
I
L
E
N
Y
Q
Q
E
D
G
S
V
V
V
P
E
V
L
R
D
Y
V
G
T
---
D
V
I
R
P
--------------
35
HHSearch
86.51
59%
-78
- C3 -
2DQ3
1
SYS_AQUAE
A:
[1-422]
-----------------------------------------------------------------------------------------------
M
I
D
I
N
L
I
R
----
E
----
K
--
P
D
Y
V
K
E
R
L
A
T
R
--
D
K
--
E
L-
V
--
S
L
V
-
D
K
V
L
E
L
D
K
R
R
R
E
I
I
K
R
L
-------
E
A
L
R
S
E
R
N
K
L
S
K
E
I
G
K
L
K
R
E
G
--------
K
-
D
-----------------------------
T
------------------------
T
E
I
Q
N
R
V
K
E
-
L
K
E
E
I
D
R
L
E
E
E
L
R
K
V
E
E
E
L
K
N
T
L
----
L
W
I
P
N
L
P
H
P
S
V
P
V
G
E
D
E
-
K
-
D
-
N
V
E
V
R
R
W
G
--------------------
E
P
R
------
K
--------------------
F
D
F
E
P
K
P
H
W
E
I
G
E
R
L
G
I
L
D
F
K
R
G
-
A
-
K
L
S
-
G
S
R
F
T
V
I
A
G
W
G
A
R
L
E
R
A
L
I
N
F
M
L
D
L
H
T
-
K
K
G
Y
K
E
I
C
P
P
H
L
V
K
P
E
I
L
I
G
T
G
Q
L
P
K
F
E
-
E
D
L
Y
K
C
-----------
E
R
---
D
N
--
L
Y
L
I
P
T
A
E
V
P
L
T
N
L
Y
R
E
E
I
L
--
K
--
E
E
N
L
P
I
Y
L
T
A
Y
T
P
C
Y
R
R
E
A
G
A
Y
G
K
D
I
R
G
I
I
R
Q
H
Q
F
D
K
V
E
L
V
K
I
V
H
P
--
D
--
T
--
S
Y
D
----
E
L
E
K
L
V
K
D
A
E
E
V
L
Q
L
L
G
L
P
Y
R
V
V
E
L
C
T
G
D
L
G
F
S
A
A
K
T
Y
D
I
E
V
W
F
P
S
Q
N
K
Y
R
E
I
S
S
C
S
N
C
E
D
F
Q
A
R
R
M
N
T
R
--
F
K
D
S
K
T
--
G
-----
K
N
-----
R
F
V
H
T
L
N
G
S
G
L
A
V
G
R
T
L
A
A
I
L
E
N
Y
Q
Q
E
D
G
S
V
V
V
P
E
V
L
R
D
Y
V
G
T
D
--
V
I
-----------------
21
PsiBlast_CBE
81.43
42%
-71
- C3 -
2ZR2
4
SYS_PYRHO
B:
[1-444]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
--
P
E
L
V
K
N
D
L
I
K
R
--
G
E
LE
K
--
V
--
K
W
V
-
D
E
I
L
K
L
D
T
E
W
R
T
K
L
K
E
I
-------
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
--------
E
-
P
-----------------------------
V
------------------------
D
E
L
L
A
K
S
R
E
-
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
----
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
-
D
-
N
V
P
I
R
F
W
G
KARVWKGHLERFLEQSQGKM
E
Y
E
------
I
--------------------
L
E
W
K
P
K
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
-
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
-
D
V
I
Y
K
V
-----------
E
D
---
E
D
--
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
--
S
W
E
----
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
--
F
R
D
R
T
D
--
E
-----
K
P
-----
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
--
E
I
V
----------------
38
HHSearch
80.87
44%
-69
- C3 -
2DQ0
5
SYS_PYRHO
A:
[1-445]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
--
P
E
L
V
K
N
D
L
I
K
R
--
G
E
--
L
EK
V
--
K
W
V
-
D
E
I
L
K
L
D
T
E
W
R
T
K
L
K
E
I
-------
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
--------
E
-
P
-----------------------------
V
------------------------
D
E
L
L
A
K
S
R
E
-
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
----
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
-
D
-
N
V
P
I
R
F
W
G
--------------------
K
A
R
------
V
WKGH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
K
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
-
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
-
D
V
I
Y
K
V
-----------
E
D
---
E
D
--
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
--
S
W
E
----
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
--
F
R
D
R
T
D
--
E
-----
K
P
-----
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
--
E
I
V
P
---------------
2
PsiBlast_PDB
79.84
42%
-70
- C3 -
2DQ0
5
SYS_PYRHO
A:
[1-444]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
--
P
E
L
V
K
N
D
L
I
K
R
--
G
E
LE
K
--
V
--
K
W
V
-
D
E
I
L
K
L
D
T
E
W
R
T
K
L
K
E
I
-------
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
--------
E
-
P
-----------------------------
V
------------------------
D
E
L
L
A
K
S
R
E
-
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
----
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
-
D
-
N
V
P
I
R
F
W
G
KARVWKGH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
------
I
--------------------
L
E
W
K
P
K
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
-
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
-
D
V
I
Y
K
V
-----------
E
D
---
E
D
--
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
--
S
W
E
----
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
--
F
R
D
R
T
D
--
E
-----
K
P
-----
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
--
E
I
V
----------------
22
PsiBlast_CBE
79.78
42%
-71
- C3 -
2DQ0
4
SYS_PYRHO
B:
[1-444]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
--
P
E
L
V
K
N
D
L
I
K
R
--
G
E
LE
K
--
V
--
K
W
V
-
D
E
I
L
K
L
D
T
E
W
R
T
K
L
K
E
I
-------
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
--------
E
-
P
-----------------------------
V
------------------------
D
E
L
L
A
K
S
R
E
-
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
----
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
-
D
-
N
V
P
I
R
F
W
G
KARVWKGHLERFLEQSQGKM
E
Y
E
------
I
--------------------
L
E
W
K
P
K
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
-
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
-
D
V
I
Y
K
V
-----------
E
D
---
E
D
--
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
--
S
W
E
----
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
--
F
R
D
R
T
D
--
E
-----
K
P
-----
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
--
E
I
V
----------------
3
PsiBlast_PDB
79.69
42%
-72
- C3 -
2ZR2
5
SYS_PYRHO
A:
[1-444]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
--
P
E
L
V
K
N
D
L
I
K
R
--
G
E
LE
K
--
V
--
K
W
V
-
D
E
I
L
K
L
D
T
E
W
R
T
K
L
K
E
I
-------
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
--------
E
-
P
-----------------------------
V
------------------------
D
E
L
L
A
K
S
R
E
-
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
----
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
-
D
-
N
V
P
I
R
F
W
G
K
A
R
V
W
KGH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
------
I
--------------------
L
E
W
K
P
K
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
-
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
-
D
V
I
Y
K
V
-----------
E
D
---
E
D
--
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
--
S
W
E
----
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
--
F
R
D
R
T
D
--
E
-----
K
P
-----
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
--
E
I
V
----------------
4
PsiBlast_PDB
79.22
42%
-68
- C3 -
2ZR3
-
SYS_PYRHO
A:
[1-444]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
--
P
E
L
V
K
N
D
L
I
K
R
--
G
E
LE
K
--
V
--
K
W
V
-
D
E
I
L
K
L
D
T
E
W
R
T
K
L
K
E
I
-------
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
--------
E
-
P
-----------------------------
V
------------------------
D
E
L
L
A
K
S
R
E
-
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
----
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
-
D
-
N
V
P
I
R
F
W
G
KARVWKGH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
------
I
--------------------
L
E
W
K
P
K
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
-
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
-
D
V
I
Y
K
V
-----------
E
D
---
E
D
--
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
--
S
W
E
----
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
--
F
R
D
R
T
D
--
E
-----
K
P
-----
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
--
E
I
V
----------------
39
HHSearch
75.50
31%
-70
* C3 *
1WLE
1
SYSM_BOVIN
A:
[40-475]
-----------------------------------------------------------------------------------------------
L
L
D
M
E
S
L
C
----
A
----
Y
--
P
E
D
A
A
R
A
L
D
L
R
--
K
G
--
E
--
L
RS
K
D
L
-
P
G
I
I
S
T
W
Q
E
L
R
Q
L
R
E
Q
I
-------
R
S
L
E
E
E
K
E
A
V
T
E
A
V
R
A
L
V
V
N
Q
DNSQVQQD
P
-
Q
-----------------------------
Y
------------------------
Q
S
L
R
A
R
G
R
E
-
I
R
K
Q
L
T
L
L
Y
P
K
E
A
Q
L
E
E
Q
F
Y
L
R
A
----
L
R
L
P
N
Q
T
H
P
D
V
P
V
G
D
E
S
---
Q
-
A
R
V
L
H
V
V
G
--------------------
D
K
P
------
A
--------------------
F
S
F
Q
P
R
G
H
L
E
I
A
E
K
L
D
I
I
R
Q
K
R
L
-
S
-
H
V
S
-
G
H
R
S
Y
Y
L
R
G
A
G
A
L
L
Q
H
G
L
V
N
F
T
L
N
K
L
I
-
H
R
G
F
T
P
M
T
V
P
D
L
L
R
G
V
V
F
E
G
C
G
M
T
P
N
A
K
P
S
Q
I
Y
N
I
-----------
D
P
SRF
E
D
--
L
N
L
A
G
T
A
E
V
G
L
A
G
Y
F
M
D
H
S
V
--
A
--
F
R
D
L
P
I
R
M
V
C
S
S
T
C
Y
R
A
E
T
D
T
-
G
--
P
W
G
L
Y
R
V
H
H
F
T
K
V
E
M
F
G
V
T
G
P
--
G
L
E
Q
--
S
S
E
----
L
L
E
E
F
L
S
L
Q
M
E
I
L
T
E
L
G
L
H
F
R
V
L
D
M
P
T
Q
E
L
G
L
P
A
Y
R
K
F
D
I
E
A
W
M
P
G
R
G
R
F
G
E
V
T
S
A
S
N
C
T
D
F
Q
S
R
R
L
H
I
M
--
F
Q
T
E
-
A
--
G
-----
E
L
-----
Q
F
A
H
T
V
N
A
T
G
C
A
V
P
R
L
L
I
A
L
L
E
S
Y
Q
Q
K
D
G
S
V
L
V
P
P
A
L
Q
P
Y
L
G
T
D
--
R
I
T
T
---------------
36
HHSearch
74.89
38%
-68
- C3 -
1SES
1
SYS_THET2
A:
[1-417]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
----
Q
----
E
--
P
E
V
F
H
R
A
I
R
E
K
--
G
V
--
A
--
L
---
D
L
-
E
A
L
L
A
L
D
R
E
V
Q
E
L
K
K
R
L
-------
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
K
A
P
P
----------
E
-
E
-----------------------------
K
------------------------
E
A
L
I
A
R
G
K
A
-
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
----
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
---
A
-
N
R
E
I
K
R
V
G
--------------------
G
P
P
------
E
--------------------
F
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
-----------
A
E
---
T
D
--
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
--
S
D
R
----
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
R
D
P
-
E
--
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
E
--
V
L
-----------------
41
HHSearch
74.24
35%
-68
- C3 -
3QNE
-
SYSC_CANAL
A:
[1-438]
-----------------------------------------------------------------------------------------------
M
L
D
I
N
A
F
L
VEKG
G
----
D
--
P
E
I
I
K
A
S
Q
K
K
R
--
G
D
--
S
--
V
--
E
L
V
-
D
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
-------
D
E
H
N
K
K
L
N
S
V
Q
K
E
I
G
K
R
F
K
A
K
--------
E
-
D
-----------------------------
A
------------------------
K
D
L
I
A
E
K
E
K
-
L
S
N
E
K
K
E
I
I
E
K
E
A
E
A
D
K
N
L
R
S
K
I
----
N
Q
V
G
N
I
V
H
E
S
V
V
D
S
Q
D
E
-
E
-
N
-
N
E
L
V
R
T
W
T
--------------------
P
E
N
------
Y
KKPEQIAAAT----------
G
A
P
A
K
L
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
-
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
L
S
-
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
-
E
E
L
Y
K
V
-----------
I
D
GE-
D
E
--
K
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
ES
P
--
A
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
--
S
W
E
----
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
--
C
G
I
-----------
E
K
-----
K
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
-
L
V
I
P
E
V
L
R
K
Y
I
P
G
E
---------------------
40
HHSearch
74.21
35%
-71
- C3 -
3VBB
2
SYSC_HUMAN
A:
[2-469]
-----------------------------------------------------------------------------------------------
V
L
D
L
D
L
F
R
----
V
DKGG
D
--
P
A
L
I
R
E
T
Q
E
K
R
--
F
K
--
D
--
P
--
G
L
V
-
D
Q
L
V
K
A
D
S
E
W
R
R
C
R
F
R
A
-------
D
N
L
N
K
L
K
N
L
C
S
K
T
I
G
E
K
M
K
K
K
--------
E
--------------------------------DESVPENVLSFDDLT
A
D
A
L
A
N
L
KV
S
Q
I
K
K
V
R
L
L
-
I
D
E
A
I
L
K
C
D
A
E
R
I
K
L
E
A
E
R
F
E
N
L
----
R
E
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
D
V
-
D
-
N
K
V
E
R
I
W
G
--------------------
D
C
T
------
V
----------------------
R
K
K
Y
S
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
-
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
L
G
-
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
-
F
D
-
E
E
L
Y
K
V
-----------
I
----
D
E
--
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
--
R
--
P
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
----
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
DN
K
--
S
W
E
----
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
--
Y
G
Q
T
--M-
D
-----
K
V
-----
E
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
M
P
P
G
LQ
E
L
I
P
---------------
57
Fugue
74.14
31%
-67
- C3 -
1WLE
1
SYSM_BOVIN
A:
[24-490]
-------------------------------------------------------------------------------RN
L
L
Y
E
H
A
R
E
GYSALP
L
L
D
M
E
S
L
C
----
A
----
Y
--
P
E
D
A
A
R
A
L
D
L
R
--
K
G
--
E
LR
S
--
K
D
L
-
P
G
I
I
S
T
W
Q
E
L
R
Q
L
R
E
Q
I
-------
R
S
L
E
E
E
K
E
A
V
T
E
A
V
R
A
L
V
V
N
Q
DNSQVQQD
P
-
Q
-----------------------------
Y
------------------------
Q
S
L
R
A
R
G
R
E
-
I
R
K
Q
L
T
L
L
Y
P
K
E
A
Q
L
E
E
Q
F
Y
L
R
A
----
L
R
L
P
N
Q
T
H
P
D
V
P
V
G
D
-
E
-
S
-
Q
-
A
R
V
L
H
V
V
G
--------------------
D
K
P
------
A
--------------------
F
S
F
Q
P
R
G
H
L
E
I
A
E
K
L
D
I
I
R
Q
K
R
L
-
S
-
H
V
S
-
G
H
R
S
Y
Y
L
R
G
A
G
A
L
L
Q
H
G
L
V
N
F
T
L
N
K
L
I
H
R
-
G
F
T
P
M
T
V
P
D
L
L
R
G
V
V
F
E
G
C
G
M
T
P
N
A
K
-
P
S
Q
I
Y
N
I
DPS-------
R
F
---
E
D
--
L
N
L
A
G
T
A
E
V
G
L
A
G
Y
F
M
D
H
S
V
--
A
--
F
R
D
L
P
I
R
M
V
C
S
S
T
C
Y
R
A
E
T
D
T
---
G
P
W
G
L
Y
R
V
H
H
F
T
K
V
E
M
F
G
V
T
G
P
G
L
E
--
Q
--
S
S
E
----
L
L
E
E
F
L
S
L
Q
M
E
I
L
T
E
L
G
L
H
F
R
V
L
D
M
P
T
Q
E
L
G
L
P
A
Y
R
K
F
D
I
E
A
W
M
P
G
R
G
R
F
G
E
V
T
S
A
S
N
C
T
D
F
Q
S
R
R
L
H
I
M
--
F
Q
T
E
-
A
--
G
-----
E
L
-----
Q
F
A
H
T
V
N
A
T
G
C
A
V
P
R
L
L
I
A
L
L
E
S
Y
Q
Q
K
D
G
S
V
L
V
P
P
A
L
Q
P
Y
L
G
T
D
--
R
I
T
T
P
THVPLQYIGPNQPQ
12
PsiBlast_PDB
73.57
34%
-66
- C3 -
3QO8
4
SYSC_CANAL
A:
[18-435]
----------------------------------------------------------------------------------------------------------------------
I
K
A
S
Q
K
K
R
--
G
D
--
S
--
V
--
E
L
V
-
D
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
-------
D
E
H
N
K
K
L
N
S
V
Q
K
E
I
G
K
R
F
K
------------
D
-----------------------------
A
------------------------
K
D
L
I
A
E
K
E
K
-
L
S
N
E
K
K
E
I
I
E
K
E
A
E
A
D
K
N
L
R
S
K
I
----
N
Q
V
G
N
I
V
H
E
S
V
V
D
S
Q
D
E
-
E
-
N
-
N
E
L
V
R
T
W
T
P
E
NY----------------
K
K
P
EQIAAA
T
--------------------
G
A
P
A
K
L
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
-
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
-
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
-
E
E
L
Y
K
V
I
D
---------
G
E
---
D
E
--
K
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
SP
A
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
S
H
G
K
D
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
--
S
W
E
----
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
CG
I
K
-------------------
K
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
-
L
V
I
P
E
V
L
R
K
Y
I
------------------------
17
PsiBlast_PDB
73.01
33%
-67
- C3 -
1WLE
1
SYSM_BOVIN
A:
[80-476]
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
L
R
E
Q
I
-------
R
S
L
E
E
E
K
E
A
V
T
E
A
V
R
A
L
V
V
N
Q
--------
D
-
N
-----------------------------
S
QVQQ--------------------
D
P
Q
Y
Q
S
L
R
A
-
R
G
R
E
I
R
K
Q
L
T
L
L
Y
P
K
E
A
Q
L
E
E
Q
F
Y
L
R
A
L
R
L
P
N
Q
T
H
P
D
V
P
V
G
D
E
S
-
Q
-
A
-
R
V
-
L
H
V
V
G
--------------------
D
K
P
------
A
--------------------
F
S
F
Q
P
R
G
H
L
E
I
A
E
K
L
D
I
I
R
Q
K
R
L
-
S
-
H
V
S
-
G
H
R
S
Y
Y
L
R
G
A
G
A
L
L
Q
H
G
L
V
N
F
T
L
N
K
L
I
H
R
-
G
F
T
P
M
T
V
P
D
L
L
R
G
V
V
F
E
G
C
G
M
T
P
N
A
K
P
S
Q
I
Y
N
I
DPS--------
R
F
---
E
D
--
L
N
L
A
G
T
A
E
V
G
L
A
G
Y
F
M
D
H
S
V
--
A
--
F
R
D
L
P
I
R
M
V
C
S
S
T
C
Y
R
A
E
T
D
T
-
G
--
P
W
G
L
Y
R
V
H
H
F
T
K
V
E
M
F
G
V
T
G
P
G
L
E
--
Q
--
S
S
E
----
L
L
E
E
F
L
S
L
Q
M
E
I
L
T
E
L
G
L
H
F
R
V
L
D
M
P
T
Q
E
L
G
L
P
A
Y
R
K
F
D
I
E
A
W
M
P
G
R
G
R
F
G
E
V
T
S
A
S
N
C
T
D
F
Q
S
R
R
L
H
I
M
--
F
Q
T
E
A
---
G
-----
E
L
-----
Q
F
A
H
T
V
N
A
T
G
C
A
V
P
R
L
L
I
A
L
L
E
S
Y
Q
Q
K
D
G
S
V
L
V
P
P
A
L
Q
P
Y
L
G
T
D
--
R
I
T
T
P
--------------
9
PsiBlast_PDB
72.77
35%
-67
- C3 -
3QO5
-
SYSC_CANAL
A:
[18-435]
----------------------------------------------------------------------------------------------------------------------
I
K
A
S
Q
K
K
R
--
G
D
--
S
--
V
--
E
L
V
-
D
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
-------
D
E
H
N
K
K
L
N
S
V
Q
K
E
I
G
K
R
F
---------------------------------------------------------------------
D
L
I
A
E
K
E
K
-
L
S
N
E
K
K
E
I
I
E
K
E
A
E
A
D
K
N
L
R
S
K
I
----
N
Q
V
G
N
I
V
H
E
S
V
V
D
S
Q
D
E
-
E
-
N
-
N
E
L
V
R
T
W
T
P
ENY----------------
K
K
P
EQIAAA
T
--------------------
G
A
P
A
K
L
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
-
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
-
L
F
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
-
E
E
L
Y
K
V
I
D---------
G
E
---
D
E
--
K
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
SP
A
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
--
S
W
E
----
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
CG
I
-------------
E
K
-----
K
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
-
L
V
I
P
E
V
L
R
K
Y
I
------------------------
11
PsiBlast_PDB
72.60
34%
-66
- C3 -
3QO7
1
SYSC_CANAL
A:
[18-435]
----------------------------------------------------------------------------------------------------------------------
I
K
A
S
Q
K
K
R
--
G
D
--
S
--
V
--
E
L
V
-
D
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
-------
D
E
H
N
K
K
L
N
S
V
Q
K
E
I
G
K
R
F
K
A
K
--------
E
-
D
-----------------------------
A
------------------------
K
D
L
I
A
E
K
E
K
-
L
S
N
E
K
K
E
I
I
E
K
E
A
E
A
D
K
N
L
R
S
K
I
----
N
Q
V
G
N
I
V
H
E
S
V
V
D
S
Q
D
E
-
E
-
N
-
N
E
L
V
R
T
W
T
P
ENY----------------
K
K
P
EQIAAA
T
--------------------
G
A
P
A
K
L
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
-
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
-
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
-
E
E
L
Y
K
V
I
D---------
G
E
---
D
E
--
K
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
SP
A
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
--
S
W
E
----
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
CG
I
-------------
E
K
-----
K
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
-
L
V
I
P
E
V
L
R
K
Y
I
------------------------
10
PsiBlast_PDB
72.57
34%
-67
- C3 -
3QNE
-
SYSC_CANAL
A:
[18-435]
----------------------------------------------------------------------------------------------------------------------
I
K
A
S
Q
K
K
R
--
G
D
--
S
--
V
--
E
L
V
-
D
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
-------
D
E
H
N
K
K
L
N
S
V
Q
K
E
I
G
K
R
F
K
A
K
--------
E
-
D
-----------------------------
A
------------------------
K
D
L
I
A
E
K
E
K
-
L
S
N
E
K
K
E
I
I
E
K
E
A
E
A
D
K
N
L
R
S
K
I
----
N
Q
V
G
N
I
V
H
E
S
V
V
D
S
Q
D
E
-
E
-
N
-
N
E
L
V
R
T
W
T
PENY----------------
K
K
P
EQIAAA
T
--------------------
G
A
P
A
K
L
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
-
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
-
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
-
E
E
L
Y
K
V
I
D---------
G
E
---
D
E
--
K
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
SP
A
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
--
S
W
E
----
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
CG
I
-------------
E
K
-----
K
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
-
L
V
I
P
E
V
L
R
K
Y
I
------------------------
37
HHSearch
71.70
35%
-60
- C3 -
3LSS
4
?
A:
[7-468]
-----------------------------------------------------------------------------------------------
V
L
D
I
Q
L
F
R
----
D
----
E
T
G
A
N
I
I
R
E
S
Q
R
R
R
--
F
A
--
D
--
P
--
D
I
V
-
D
A
I
I
E
A
D
K
K
W
R
R
T
Q
F
L
T
-------
E
A
S
K
K
L
I
N
I
C
S
K
A
V
G
A
K
K
K
A
K
--------
E
A
C
-----------------------------
V
------------------------
L
Q
L
K
Q
L
S
K
D
-
L
S
D
Q
V
A
G
L
A
K
E
A
Q
Q
L
E
E
E
R
D
K
L
M
----
L
N
V
G
N
I
L
H
E
S
V
P
I
A
Q
D
E
E
T
-
G
-
N
T
V
V
R
T
F
G
--------------------
N
T
T
------
K
----------------------
R
A
K
L
N
H
V
S
I
M
E
R
L
G
M
M
D
T
S
K
A
-
V
T
S
M
A
-
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
-
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
-
E
E
L
Y
Q
V
-----------
S
G
D
G
-
D
K
--
K
Y
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
--
T
--
E
L
K
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
Q
F
V
V
C
S
P
--
R
QE
E
--
S
W
R
----
H
L
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
--
Y
G
P
N
L
R
Q-
N
-----
V
K
-----
E
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
I
--
E
M
I
R
---------------
59
Fugue
71.32
35%
-63
- C3 -
3LSS
2
?
B:
[3-470]
-------------------------------------------------------------------------------------------G
S
M
M
V
L
D
I
Q
L
F
R
D
E
--
T
----
G
--
A
N
I
I
R
E
S
Q
R
R
R
--
F
A
--
D
--
P
--
D
I
V
-
D
A
I
I
E
A
D
K
K
W
R
R
T
Q
F
L
T
-------
E
A
S
K
K
L
I
N
I
C
S
K
A
V
G
A
K
K
K
A
K
--------
E
-
A
DGDTSEIP
P
Q
V
K
E
A
Y
E
N
GTLK
G
E
Q
V
E
Q
LC
V
------------------------
L
Q
L
K
Q
L
S
K
D
-
L
S
D
Q
V
A
G
L
A
K
E
A
Q
Q
L
E
E
E
R
D
K
L
M
----
L
N
V
G
N
I
L
H
E
S
V
P
I
A
Q
D
E
-
E
-
T
G
N
T
V
V
R
T
F
G
--------------------
N
T
T
------
K
----------------------
R
A
K
L
N
H
V
S
I
M
E
R
L
G
M
M
D
T
S
K
A
-
V
-
T
S
M
A
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
-
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
-
E
E
L
Y
Q
V
S
G---------
D
G
---
D
K
--
K
Y
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
--
T
--
E
L
K
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
Q
F
V
V
C
S
P
RQ
E
--
E
--
S
W
R
----
H
L
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
--
Y
G
P
N
L
R
--
G
TAAQN
V
K
-----
E
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
I
--
E
M
I
R
F
E-------------
7
PsiBlast_PDB
70.24
39%
-57
- C3 -
1SET
1
SYS_THET2
A:
[38-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
L
K
K
R
L
-------
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
K
A
P
P
E
E
--------
K
-
E
-----------------------------
A
--------------------------
L
I
A
R
G
K
A
-
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
----
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
E
-
E
-
A
-
N
R
E
I
K
R
V
G
--------------------
G
P
P
------
E
--------------------
F
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
-
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
-----------
A
E
---
T
D
--
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
--
Q
Y
V
L
T
--
E
--
A
--
S
L
E
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
-
R
D
P
E
--
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-
K
--
E
V
L
E
P
--------------
23
PsiBlast_CBE
69.76
39%
-56
- C3 -
1SET
1
SYS_THET2
B:
[38-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
L
K
K
R
L
-------
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
K
A
P
P
E
E
--------
K
-
E
-----------------------------
A
--------------------------
L
I
A
R
G
K
A
-
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
----
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
E
-
E
-
A
-
N
R
E
I
K
R
V
G
--------------------
G
P
P
------
E
--------------------
F
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
-
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
-----------
A
E
---
T
D
--
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
--
Q
Y
V
L
T
--
E
--
A
--
S
L
E
ASDR
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
-
R
D
P
E
--
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-
K
--
E
V
L
E
P
--------------
6
PsiBlast_PDB
69.51
39%
-60
- C3 -
1SES
1
SYS_THET2
A:
[38-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
L
K
K
R
L
-------
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
K
A
P
P
E
E
--------
K
-
E
-----------------------------
A
--------------------------
L
I
A
R
G
K
A
-
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
----
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
E
-
E
-
A
-
N
R
E
I
K
R
V
G
--------------------
G
P
P
------
E
--------------------
F
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
-
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
-----------
A
E
---
T
D
--
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
--
Q
Y
V
L
T
--
E
--
A
--
S
L
E
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
-
R
D
P
E
--
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-
K
--
E
V
L
E
P
--------------
24
PsiBlast_CBE
69.17
39%
-56
- C3 -
1SES
1
SYS_THET2
B:
[38-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
L
K
K
R
L
-------
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
K
A
P
P
E
E
--------
K
-
E
-----------------------------
A
--------------------------
L
I
A
R
G
K
A
-
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
----
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
E
-
E
-
A
-
N
R
E
I
K
R
V
G
--------------------
G
P
P
------
E
--------------------
F
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
-
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
-----------
A
E
---
T
D
--
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
--
Q
Y
V
L
T
--
E
--
A
--
S
L
E
ASDR
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
-
R
D
P
E
--
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-
K
--
E
V
L
E
P
--------------
14
PsiBlast_PDB
67.56
38%
-72
- C3 -
4L87
4
SYSC_HUMAN
A:
[102-459]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
K
V
R
L
L
I
D
E
A
I
L
K
C
D
A
E
R
I
K
L
E
A
E
R
F
E
N
L
----
R
E
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
-
D
V
D
-
N
K
V
E
R
I
W
G
--------------------
D
--------
C
--------------------
T
V
R
K
K
Y
S
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
-
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
-
L
G
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
Q
F
D
-
E
E
L
Y
K
V
I
G
KGSEKSDDN
S
Y
---
D
E
--
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
--
R
--
P
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
H
G
R
D
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
--
D
N
K
S
W
E
----
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
--
Y
G
Q
T
K
K
MM
D
-----
K
V
-----
E
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
M
------------------------
58
Fugue
66.42
33%
-54
- C3 -
3ERR
1
DYHC1_MOUSE (first)
A:
[3-529]
D
L
K
R
L
R
Q
E
P
E
V
F
H
R
A
I
R
E
K
GVALD
L
E
A
L
L
A
V
D
E
Q
L
H
K
Q
Q
E
V
I
A
D
K
Q
M
S
V
K
E
D
L
D
K
V
E
P
A
V
I
E
A
Q
N
A
V
K
S
IK
K
Q
H
L
V
E
V
R
S
MANPP
A
A
V
K
L
A
L
E
S
I
A
L
L
L
G
E
S
T
----
T
----
D
--
W
K
Q
I
R
S
I
I
M
R
E
N
F
I
P
--
T
--
I
--
V
N
F
-
S
A
E
E
I
S
D
A
I
R
E
K
M
K
K
N
Y
MSNPSYN
Y
E
I
V
N
R
A
S
L
A
A
G
P
M
V
K
W
A
I
A
Q
--------
L
-
N
-----------------------------
Y
------------------------
A
D
M
L
K
R
V
E
P
-
L
R
N
E
L
Q
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
----
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
-
E
-
E
-
A
-
N
R
E
I
K
R
V
G
--------------------
G
P
P
------
E
--------------------
F
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
-
W
W
E
P
R
I
-
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
-
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
-----------
A
E
---
T
D
--
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
--
S
D
R
----
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
R
-
D
P
E
--
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
E
--
V
L
E
P
G
--------------
33
PsiBlast_CBE
66.33
37%
-68
- C3 -
4RQF
2
SYSC_HUMAN
B:
[103-460]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
K
V
R
L
L
I
D
E
A
I
L
K
C
D
A
E
R
I
K
L
E
A
E
R
F
E
N
L
----
R
E
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
-
D
V
D
-
N
K
V
E
R
I
W
G
--------------------
D
--------
C
--------------------
T
V
R
K
K
Y
S
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
-
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
-
L
G
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
Q
F
D
-
E
E
L
Y
K
V
I
G
KGSEKSDDN
S
Y
---
D
E
--
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
--
R
--
P
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
H
G
R
D
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
--
D
N
K
S
W
E
----
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
--
Y
G
Q
T
K
K
MM
D
-----
K
V
-----
E
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
K
K
G
-
I
T
V
P
E
K
L
K
E
F
M
------------------------
42
HHSearch
66.11
38%
-70
- C3 -
3ERR
1
DYHC1_MOUSE (first)
A:
[178-526]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
K
R
V
E
P
-
L
R
N
E
L
Q
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
----
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
---
A
-
N
R
E
I
K
R
V
G
--------------------
G
P
P
------
E
--------------------
F
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
W
E
P
-
R
I
-
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
-----------
A
E
---
T
D
--
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
--
S
D
R
----
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
R
D
P
-
E
--
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
E
--
V
L
-----------------
16
PsiBlast_PDB
66.08
37%
-69
- C3 -
4RQF
2
SYSC_HUMAN
A:
[103-460]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
K
V
R
L
L
I
D
E
A
I
L
K
C
D
A
E
R
I
K
L
E
A
E
R
F
E
N
L
----
R
E
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
-
D
V
D
-
N
K
V
E
R
I
W
G
--------------------
D
--------
C
--------------------
T
V
R
K
K
Y
S
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
-
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
-
L
G
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
Q
F
D
-
E
E
L
Y
K
V
I
G
KGSEKSDDN
S
Y
---
D
E
--
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
--
R
--
P
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
H
G
R
D
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
--
D
N
K
S
W
E
----
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
--
Y
G
Q
T
--MM
D
-----
K
V
-----
E
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
K
K
G
-
I
T
V
P
E
K
L
K
E
F
M
------------------------
26
PsiBlast_CBE
65.05
36%
-61
- C3 -
3LSS
2
?
B:
[96-468]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
E
Q
V
E
---
Q
L
C
V
L
Q
L
K
Q
--------
L
-
S
-----------------------------
K
------------------------
D
---------
L
S
D
Q
V
A
G
L
A
K
E
A
Q
Q
L
E
E
E
R
D
K
L
M
----
L
N
V
G
N
I
L
H
E
S
V
P
I
A
Q
D
E
-
E
T
G
-
N
T
V
V
R
T
F
G
--------------------
N
T
T
------
K
--------------------
R
A
--
K
L
N
H
V
S
I
M
E
R
L
G
M
M
D
T
S
K
A
V
T
-
S
M
A
-
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
K
R
-
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
-
E
E
L
Y
Q
V
-----------
S
G
---
D
G
D
K
K
Y
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
--
T
--
E
L
K
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
Q
F
V
V
C
S
P
RQ
E
--
E
--
S
W
R
----
H
L
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
--
Y
G
P
N
L
R
--
G
-----
T
A
AQN
V
K
E
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
I
--
E
M
I
R
---------------
8
PsiBlast_PDB
64.49
38%
-59
- C3 -
3ERR
1
DYHC1_MOUSE (first)
A:
[178-528]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
K
R
V
E
P
-
L
R
N
E
L
Q
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
----
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
E
-
E
-
A
-
N
R
E
I
K
R
V
G
--------------------
G
P
P
------
E
--------------------
F
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
-
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
-----------
A
E
---
T
D
--
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
--
Q
Y
V
L
T
--
E
--
A
--
S
L
E
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
-
R
D
P
E
--
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-
K
--
E
V
L
E
P
--------------
25
PsiBlast_CBE
64.05
38%
-60
- C3 -
3ERR
1
SYS_THET2
B:
[178-528]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
K
R
V
E
P
-
L
R
N
E
L
Q
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
----
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
E
-
E
-
A
-
N
R
E
I
K
R
V
G
--------------------
G
P
P
------
E
--------------------
F
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
-
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
-----------
A
E
---
T
D
--
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
--
Q
Y
V
L
T
--
E
--
A
--
S
L
E
ASDR
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
-
R
D
P
E
--
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-
K
--
E
V
L
E
P
--------------