@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu00550: (2016-06-02 )
MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSALANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQRLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEVGYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETLTSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSEGQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLLEEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQMNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYIMEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVHINHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLYKLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQETEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTTILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKDVVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLVPDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKMGLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRDLTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAYIPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVYARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQTKGRSADEWLDTVLGMLKGLKDVKKQTISST
Atome Classification :
(20 SA)
........----.10........20....----....30........40........50.........60........70..-------......80.-------------.......90.-.......100.......110.......120.......130.......140.......150.......160.......170.......180.....-..190.......200.......210.......220.......230.......240.......250....---..---.260....-----...270.......280.......290---..--.-.-.-----....300.......310-........320.......330...-.----.-----.-----.340.......350.....-..-360.......370----------.......380..---------...--..------390...---....400....-...410.......420.......430...-....----------440--------......--...450..--.....460.......470.......--480.------...-...-490..-.....------.500.--------......510-........520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620-.......630.......640.......650.......660.......670--------------------........680.......690......-.-700.......710.......720.......730.......-----740------.........750.......---760----.----.----..---.----.----.----.770.......780.......790-........--800----.--.--.-.....810...---.--.---.----.820.....-----------...--830.......840.......850-----.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010...--.--...---1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MD
N
I
Q
T
F
I
----KESD
D
F
K
S
I
I
N
G
L
H
E
G
L
----
K
E
Q
L
L
A
GLSG
S
A
R
S
V
F
T
S
A
L
ANETN-K
P
I
F
L
I
THNL
Y
Q
A
Q
K
V
T
D
D
L
T
S
L
-------
L
EDR
S
V
L
L
Y
-------------
P
V
N
E
L
I
S
S
E
I-AVA
S
P
E
L
R
A
Q
R
L
D
V
I
N
R
LTNGEA
P
I
V
VA
P
V
A
A
I
R
RMLP
P
V
E
V
WKSS
Q
M
L
I
QVGHDI
E
P
D
Q
L
A
S
R
L
V
E
VGYERSDMVSAPG
E
F
S
IRG
G
I
I
D
I
Y
PLT-SEN
P
V
R
I
E
L
FDTE
V
D
S
I
RSFNS
D
D
Q
R
S
I
E
T
L
TSINIG
P
A
K
E
L
I
IR
P
E
E
K
A
R
A
M
E
K
I
D
S
G
L
A
A
S
L
K
K
L
KA---
D
K
---
Q
K
E
I
L
HAN-----ISH
D
K
E
R
LSEGQ
T
D
Q
E
L
V
K
Y
L
S
Y
F
-----
Y
E--K-
P
-
A
-----
S
L
LDYTPD
N
T
L
L
I
L
D
E
--
V
S
R
I
H
E
M
E
E
Q
L
Q
K
E
E
A
E
F
I
T
N
L
L
E-E----G-----
K
-----
I
L
H
D
I
R
L
S
F
S
F
Q
K
I
V
A
E
QK-RP-
L
L
Y
Y
S
L
F
L
R
H
VHH----------TSPQ
N
I
VNVSG
R
---------
Q
M
Q
--
S
F
------HG
Q
M
N
V
---
L
A
G
E
M
E
R
FKKS-N
F
T
V
V
F
LGA
N
K
E
R
T
Q
K
L
S
S
V
L
A
D
YDI
E
A
A-MTDS----------
K
----------
K
A
L
VQG--
Q
V
Y
I
MEGE--LQSGFELP
L
M
K
L
A
V
I
T
E
E
E
L
F
K
N
R
V
--KKK
P
------
R
K
Q
-KLT-
N
A
-
E
R
-
I
K
S
Y
S------ELQIG--------
D
Y
V
V
H
INH--GI
G
K
YLG
I
E
T
L
E
INGIH
K
D
Y
L
N
I
H
Y
QGSD
K
L
Y
V
P
V
E
Q
I
D
Q
V
Q
K
Y
VGSEGKEP
K
L
Y
KLG
G
S
E
W
K
R
V
K
K
K
V
E
T
S
V
Q
D
I
A
D
D
L
I
K
L
Y
A
E
R
EASKGYAFSP
D
H
E
M
Q
R
E
F
E
SAFPY-
Q
E
T
E
D
Q
L
R
S
I
H
E
I
K
K
D
M
E
R
ER
P
M
D
R
L
LCGDVGYG
K
T
E
V
A
I
R
A
A
F
K
AIGD---------------------G
K
Q
V
A
L
L
V
P
T
T
I
L
A
Q
Q
H
Y
E
T
I
K
E
R
F
QD-Y-PI
N
I
G
L
L
S
R
F
R
T
R
K
E
A
N
E
T
I
K
GLKNG
T
V
D
I
V
IG
T
H
R
L
L
S
K
-----
D
--------
V
V
Y
KDL
G
L
L
I
IDE
E
Q
RFG
V
---
T
H
-----
K
----
E
----
K
I
---
K
----
Q
----
I
----KANV
D
V
L
T
L
TATPIP
R
T
L
H
M
S
M
L--GV
R
D
L
S
V
I--ET-----P--P--E-NRF
P
V
Q
T
Y
V
V
E---Y--N---
G
----
A
L
-
V
R
E
A
I
E
-----------
R
E
L
--ARGG
Q
V
Y
F
L
Y
N
R
V
E
D
I
E
R
K
A
D
E
I
-----
S
M
LVPD
A
K
V
A
Y
AHGKM
T
E
N
E
L
E
T
V
M
L
S
F
LEGES
D
V
L
V
S
T
T
I
I
ETGVDIPNV
N
T
L
I
V
FD
A
D
K
M
G
L
S
Q
L
Y
Q
L
R
GRVGRSN
R
V
A
Y
A
Y
F
T
Y
R
R
D
K
V
L
T
E
V
A
E
K
R
L
Q
A
I
K
E
F
T
E
LGSG
F
K
I
A
M
R
D
L
T
I
RGAGNLLG
A
Q
QHG
F
I
D
S
V
G
F
D
L
Y
S
Q
M
L
K
E
A
I
E
ERK-GDTAK--T--EQF---E
T
E
I
D
V
E
L
DAYI
P
E
T
Y
I
Q
D
G
K
Q
K
I
D
M
Y
K
R
F
R
S
V
AT
I
E
E
K
N
E
L
Q
D
E
M
I
D
R
FGNY
P
K
E
V
E
Y
L
F
T
V
A
E
M
K
V
Y
A
R
Q
E
R
V
E
L
I
KQDK
D
A
V
R
L
T
ISEEASAEI
D
G
Q
K
L
F
E
L
G
N
Q
Y
G
R
QIGLGMEG
K
K
L
K
I
S
I
Q
TKGR
S
A
D
E
W
L
D
T
V
L
G
M
L
K
G
L
K
D
V
K
K
Q
TISST
66
Fugue
85.26
35%
-70
- C2 -
2EYQ
5
MFD_ECOLI
A:
[5-1150]
------------
P
E
Q
Y
R
Y
T
L
P
V
K
A
G
E
Q
--------
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
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I
S
Q
F
-------
T
-
D
Q
M
V
M
N
L
-------------
A
D
W
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T
L
P
Y
D
S
-
F
S
P
H
Q
D
I
I
S
S
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L
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Q
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L
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A
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A
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L
L
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----
P
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K
A
A
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F
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V
K
R
D
---
P
E
------------------
H
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
-----
F
S
--
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-
P
L
P
-----
P
L
F
S
Y
F
P
A
N
T
L
L
V
N
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-------
D
L
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A
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R
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Q
A
D
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L
A
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N
-
R
----
G
-----
V
DPM
R
P
L
L
P
P
Q
S
L
W
L
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D
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L
F
S
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L
K
-
N
----
W
P
R
V
Q
L
K
T
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H
L
----------
P
T
K
A
A
N
A
N
L
G
F
Q
---------
K
L
P
--
D
L
------
A
V
Q
A
Q
Q
KAP
L
D
A
L
R
K
F
L
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-
D
G
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D
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N
L
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------
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------
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L
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--------
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--
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N
---------------------
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M
R
E
L
E
E
N
A
I
------
76
HHSearch
85.07
35%
-70
- C2 -
2EYQ
5
MFD_ECOLI
A:
[16-1149]
---------------------------
A
G
----
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
-------
T
-
D
Q
M
V
M
N
L
-------------
A
D
W
E
T
L
P
Y
D
S
-
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
--------------------
K
R
D
-----
P
E
H
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
-----
F
S
--
E
P
L
-
P
-----
P
L
F
S
Y
F
P
A
N
T
L
L
--
V
N
--
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
-
D
PM
R
P
L
-----
L
-----
P
P
Q
S
--
L
W
L
R
V
D
E
L
F
S
E
L
K
-
N
W
P
R
V
Q
L
K
T
E
H
L
P
T
--------------
K
A
A
N
A
N
L
G
F
Q
---------
K
L
P
--
D
L
AVQAQQ
K
A
P
L
D
A
---
L
R
K
F
L
E
T
F
----
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
-
R
I
M
R
----------
L
----------
D
E
A
S
D
R
--
G
R
Y
L
M
I
G
A
--
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
G
E
R
V
--
A
R
R
R
------
Q
D
S
R
R
T
I
-
N
P
D
T
L
-
I
R
N
L
A
------
E
L
H
I
G
--------
Q
P
V
V
H
L
E
H
--
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
N
---------------------
H
K
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
-
W
-
P
V
R
I
E
M
I
S
R
F
R
S
A
K
E
Q
T
Q
I
L
A
E
V
A
E
G
K
I
D
I
L
I
G
T
H
K
L
L
Q
S
-----
D
--------
V
K
F
K
D
L
G
L
L
I
V
D
E
E
H
R
F
G
V
---
R
H
-----
K
----
E
----
R
I
---
K
----
A
----
M
----
R
A
N
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
S
--
G
M
R
D
L
S
I
I
--
A
T
-----
P
--
P
--
A
-
R
R
L
A
V
K
T
F
V
R
E
---
Y
--
D
---
S
----
M
V
-
V
R
E
A
I
L
-----------
R
E
I
--
L
R
G
G
Q
V
Y
Y
L
Y
N
D
V
E
N
I
Q
K
A
A
E
R
L
-----
A
E
L
V
P
E
A
R
I
A
I
G
H
G
Q
M
R
E
R
E
L
E
R
V
M
N
D
F
H
H
Q
R
F
N
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
E
R
A
D
H
F
G
L
A
Q
L
H
Q
L
R
G
R
V
G
R
S
H
H
Q
A
Y
A
W
L
L
T
P
H
P
K
A
M
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
D
L
G
A
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
I
G
F
S
L
Y
M
E
L
L
E
N
A
V
D
A
L
K
-
A
G
R
E
P
SL
E
DL
T
S
Q
---
Q
T
E
V
E
L
R
M
P
S
L
L
P
D
D
F
I
P
D
V
N
T
R
L
S
F
Y
K
R
I
A
S
A
K
T
E
N
E
L
E
E
I
K
V
E
L
I
D
R
F
G
L
L
P
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
G
I
R
K
L
E
G
N
E
K
G
G
V
I
E
F
A
E
K
-
N
H
-
V
N
P
A
W
L
I
G
L
L
Q
K
Q
P
Q
H
Y
R
L
D
G
P
T
R
-
L
K
F
I
Q
D
L
--
S
E
R
K
T
R
I
E
W
V
R
Q
F
M
R
E
L
E
E
N
A
-------
21
PsiBlast_CBE
85.00
37%
-70
- C2 -
2EYQ
5
MFD_ECOLI
B:
[18-1075]
---------------------------------
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
TD
Q
M
V
M
N
L
A
D
W
E
T
L
P
Y
DSFS---------
P
H
Q
D
I
I
S
S
-------------
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
---
P
T
D
K
A
-
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
-
V
K
R
---
D
P
---
E
--------------
H
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
-----
F
S
--
E
-
P
L
P
-----
P
L
F
S
Y
F
P
A
N
T
L
L
V
-------
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
-
R
----
G
VDPMR
P
-----
L
L
P
P
Q
S
L
W
L
R
V
D
E
L
F
S
E
L
K
-
N
----
W
P
R
V
Q
L
K
T
E
H
L
----------
P
T
K
A
A
N
A
N
L
G
F
Q
---------
K
L
P
DL
A
V
------
Q
A
Q
Q
K
A
---
P
L
D
A
L
R
K
F
L
E
T
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
M
R
L
----------
D
----------
E
A
S
D
R
G
--
R
-
Y
L
M
I
G
A
--
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
G
E
R
V
--
A
R
R
R
------
Q
D
S
-
R
R
T
I
N
P
-
D
T
L
I
R
N
L
A
------
E
L
H
I
G
--------
Q
P
V
V
H
L
E
H
--
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
N
---------------------
H
K
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
-
W
-
P
V
R
I
E
M
I
S
R
F
R
S
A
K
E
Q
T
Q
I
L
A
E
V
A
E
G
K
I
D
I
L
I
G
T
H
K
L
L
Q
S
-----
D
--------
V
K
F
K
D
L
G
L
L
I
V
D
E
E
H
R
F
G
V
---
R
H
-----
K
----
E
----
R
I
---
K
----
A
----
M
----
R
A
N
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
S
--
G
M
R
D
L
S
I
I
--
A
T
-----
P
--
P
--
A
-
R
R
L
A
V
K
T
F
V
R
E
---
Y
--
D
---
S
----
M
V
-
V
R
E
A
I
L
-----------
R
E
I
--
L
R
G
G
Q
V
Y
Y
L
Y
N
D
V
E
N
I
Q
K
A
A
E
R
L
-----
A
E
L
V
P
E
A
R
I
A
I
G
H
G
Q
M
R
E
R
E
L
E
R
V
M
N
D
F
H
H
Q
R
F
N
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
E
R
A
D
H
F
G
L
A
Q
L
H
Q
L
R
G
R
V
G
R
S
H
H
Q
A
Y
A
W
L
L
T
P
H
P
K
A
M
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
D
L
G
A
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
I
G
F
S
L
Y
M
E
L
L
E
N
A
V
D
A
L
K
A
G
R
E
P
S
--
L
--
E
D
L
TSQ
Q
T
E
V
E
L
R
M
P
S
L
L
P
D
D
F
I
P
D
V
N
T
R
L
S
F
Y
K
R
I
A
S
A
K
T
E
N
E
L
E
E
I
K
V
E
L
I
D
R
F
G
L
L
P
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
--------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.30
37%
-70
- C2 -
2EYQ
5
MFD_ECOLI
A:
[18-1075]
---------------------------------
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
M
V
M
N
L
A
D
W
E
T
L
P
Y
DSFS---------
P
H
Q
D
I
I
S
S
-------------
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
---
P
T
D
K
A
-
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
-
V
K
R
---
D
P
---
E
--------------
H
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
-----
F
S
--
E
-
P
L
P
-----
P
L
F
S
Y
F
P
A
N
T
L
L
V
-------
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
-
R
----
G
VDPM
R
P
-----
L
L
P
P
Q
S
L
W
L
R
V
D
E
L
F
S
E
L
K
-
N
----
W
P
R
V
Q
L
K
T
E
H
L
----------
P
T
K
A
A
N
A
N
L
G
F
Q
---------
K
L
P
DL
A
V
------
Q
A
Q
Q
K
A
---
P
L
D
A
L
R
K
F
L
E
T
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
M
R
L
----------
D
----------
E
A
S
D
R
G
--
R
-
Y
L
M
I
G
A
--
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
G
E
R
V
--
A
R
R
R
------
Q
D
S
-
R
R
T
I
N
P
-
D
T
L
I
R
N
L
A
------
E
L
H
I
G
--------
Q
P
V
V
H
L
E
H
--
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
N
---------------------
H
K
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
-
W
-
P
V
R
I
E
M
I
S
R
F
R
S
A
K
E
Q
T
Q
I
L
A
E
V
A
E
G
K
I
D
I
L
I
G
T
H
K
L
L
Q
S
-----
D
--------
V
K
F
K
D
L
G
L
L
I
V
D
E
E
H
R
F
G
V
---
R
H
-----
K
----
E
----
R
I
---
K
----
A
----
M
----
R
A
N
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
S
--
G
M
R
D
L
S
I
I
--
A
T
-----
P
--
P
--
A
-
R
R
L
A
V
K
T
F
V
R
E
---
Y
--
D
---
S
----
M
V
-
V
R
E
A
I
L
-----------
R
E
I
--
L
R
G
G
Q
V
Y
Y
L
Y
N
D
V
E
N
I
Q
K
A
A
E
R
L
-----
A
E
L
V
P
E
A
R
I
A
I
G
H
G
Q
M
R
E
R
E
L
E
R
V
M
N
D
F
H
H
Q
R
F
N
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
E
R
A
D
H
F
G
L
A
Q
L
H
Q
L
R
G
R
V
G
R
S
H
H
Q
A
Y
A
W
L
L
T
P
H
P
K
A
M
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
D
L
G
A
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
I
G
F
S
L
Y
M
E
L
L
E
N
A
V
D
A
L
K
A
G
R
E
P
S
--
L
--
E
D
L
TSQ
Q
T
E
V
E
L
R
M
P
S
L
L
P
D
D
F
I
P
D
V
N
T
R
L
S
F
Y
K
R
I
A
S
A
K
T
E
N
E
L
E
E
I
K
V
E
L
I
D
R
F
G
L
L
P
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
--------------------------------------------------------------------------------------
78
HHSearch
67.57
22%
-53
- C2 -
2D7D
2
UVRB_BACSU
A:
[17-642]
-------------
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
----
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
-
K
P
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
-------
F
P
N
N
A
V
E
Y
F
V
SYYD
Y
Y
Q
P
EAYV
P
Q
T
D
T
F
-
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
-
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
V
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
GK
L
L
---
E
A
Q
R
L
E
Q
R
-----
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
LR--
P
P
GS
T
-
P
-
Y
-----
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
--
S
H
V
T
I
P
Q
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
V
D
-
H
GFRL
P
-----
S
-----
A
L
D
N
--
R
P
L
R
F
E
E
F
E
K
H
M
H
-
N
--
I
V
Y
V
S
A
T
P
G
P
Y
E
I
E
H
TDEMVEQI
I
R
P
T
G
L
-
L
D
P
L
I
---------
D
V
R
--
P
I
------
E
G
Q
I
D
D
---
L
I
G
E
I
Q
A
R
I
E
R
-
N
E
R
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
K
V
N
-
Y
L
H
S
EIK
T
L
E
R
I
E
I
I
----------
R
D
L
R
L
G
KY
D
V
L
V
G
I
N
L
--
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
--
S
E
R
S
L
I
Q
T
I
G
R
A
A
-
R
N
A
-
E
G
-
R
V
-
I
M
Y
A
D
KIT
K
S
M
E
I
A
I
N
E
T
K
R
R
R
E
Q
Q
E
R
F
N
E
E
H
--
G
I
T
P
------
K
T
I
N
--------------------------------------------
K
K
E
R
Q
K
V
V
E
Q
M
E
H
E
M
K
E
A
A
K
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Fugue
64.96
21%
-45
- C2 -
1D2M
4
UVRB_THET8
A:
[2-583]
-----
T
F
R
YRGP
S
P
K
G
D
Q
P
K
A
I
A
G
L
V
E
A
L
R
D
GE
R
F
V
T
L
L
G
A
T
G
T
G
K
T
V
T
M
A
K
V
I
E
A
L
G
-
R
P
A
L
V
L
A
P
N
K
I
L
A
A
Q
L
A
A
E
F
R
E
L
-------
F
P
E
N
A
V
E
Y
F
ISYYDYYQ
P
E
A
Y
V
P
G
K
D
L
Y
I
E
K
D
-
A
S
I
N
P
E
I
E
R
L
R
H
S
T
T
R
S
L
L
T
R
R
D
V
I
V
V
A
S
V
S
A
I
Y
G
L
G
D
P
R
E
Y
R
A
--------
R
N
L
V
V
R
E
V
L
L
E
R
L
L
E
L
G
Y
Q
R
N
D
I
D
L
S
P
G
R
F
R
A
K
G
E
V
L
E
I
F
P
A
Y
-
E
T
E
P
I
R
V
E
L
-----------------------
G
F
V
L
F
P
A
T
H
Y
L
-
S
P
E
G
L
E
E
I
L
K
E
I
E
K
E
L
W
E
R
V
R
Y
F
E
E
R
GE
V
L
---
Y
A
Q
R
L
K
E
R
-----
T
L
Y
D
L
E
M
L
R
V
M
G
T
C
P
G
V
E
N
Y
A
R
Y
F
T
GKAP
G
E
--
P
-
P
-
Y
-----
T
L
L
D
Y
F
P
E
D
F
L
V
F
L
D
E
--
S
H
V
T
V
P
Q
L
Q
G
M
Y
R
G
D
Y
A
R
K
K
T
L
V
D
-
Y
----
G
-----
F
-----
R
L
P
S
A
L
D
N
R
P
L
R
F
E
E
F
L
E
R
V
S
Q
-
V
V
F
V
S
A
T
P
G
P
F
E
L
----------
A
H
S
G
R
V
V
E
Q
I
I
R
PTGLLD
P
L
V
R
V
K
--
P
T
------
E
N
Q
I
L
D
---
L
M
E
G
I
R
E
R
A
A
R
-
G
E
R
T
L
V
T
V
L
T
V
R
M
A
E
E
L
T
S
F
L
V
E
H
G
I
R
A
R
-
Y
L
H
H
----------
E
LDA
F
K
R
Q
A
L
I
R
D
L
R
L
G
--
H
Y
D
C
L
V
G
I
NL
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
--
S
E
R
S
------
L
I
Q
-
T
I
G
-
R
A
-
A
R
-
N
A
R
------------
G
--------
E
V
W
L
Y
A
D
R
VS
E
A
M
Q
R
A
I
E
E
T
N
R
R
R
A
L
Q
E
A
Y
N
L
E
H
G
I
T
P
E
T
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
64.39
39%
-70
- C2 -
1GM5
2
?
A:
[338-750]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
K
E
R
E
K
H
G
G
I
P
K
K
I
E
G
K
L
A
E
E
F
I
K
S
L
P
F
-
K
L
T
N
A
Q
K
R
A
H
Q
E
I
R
N
D
M
I
S
E
K
P
M
N
R
L
L
Q
G
D
V
G
S
G
K
T
V
V
A
Q
L
A
I
L
D
N
Y
E
A
---------------------
G
F
Q
T
A
F
M
V
P
T
S
I
L
A
I
Q
H
Y
R
R
T
V
E
S
F
S
K
-
F
-
N
I
H
V
A
L
L
I
G
A
T
T
P
S
E
K
E
K
I
K
S
G
L
R
N
G
Q
I
D
V
V
I
G
T
H
A
L
I
Q
E
-----
D
--------
V
H
F
K
N
L
G
L
V
I
I
D
E
Q
H
R
F
-----------------
E
----
A
L
---
M
----
N
----
K
----
G
K
M
V
D
T
L
V
M
S
A
T
P
I
P
R
S
M
A
L
A
F
Y
--
G
D
L
D
V
T
V
I
--
D
E
-----
M
--
P
--
P
-
G
R
K
E
V
Q
T
M
L
V
P
---
M
--
D
---
R
----
V
N
E
V
Y
E
F
V
R
-----------
Q
E
V
--
M
R
G
G
Q
A
F
I
V
Y
P
L
I
----
K
S
A
V
E
M
Y
EYLS
K
E
V
F
---
K
L
G
L
M
H
G
R
L
S
Q
E
E
K
D
R
V
M
L
E
F
A
E
G
R
Y
D
I
L
V
S
T
T
V
I
E
V
G
I
D
V
P
R
A
N
V
M
V
I
E
N
P
E
R
F
G
L
A
Q
L
H
Q
L
R
G
R
V
G
R
G
G
Q
E
A
Y
C
F
L
------
V
V
G
D
V
G
E
E
A
M
E
R
L
R
F
F
T
L
N
T
D
G
F
K
I
A
E
Y
D
L
K
T
R
G
P
G
E
----
K
Q
H
G
L
S
G
F
K
V
A
D
L
Y
R
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
61.44
23%
-57
- C2 -
3HJH
1
MFD_ECOLI
A:
[15-450]
---------------------------------
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
DQ
M
V
M
N
L
A
D
W
E
T
L
P
Y
DSFS---------
P
H
Q
D
I
I
S
S
-------------
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
---
P
T
D
K
A
-
A
I
E
L
F
R
S
Q
W
R
D
T
F
-
E
V
K
R
---
D
P
---
E
--------------
H
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
-----
F
S
--
E
-
P
L
P
-----
P
L
F
S
Y
F
P
A
N
T
L
L
V
-------
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
-
R
----
G
VDPM
R
P
-----
L
L
P
P
Q
S
L
W
L
R
V
D
E
L
F
S
E
L
K
-
N
----
W
P
R
V
Q
L
K
T
E
H
L
----------
P
T
K
A
A
N
A
N
L
G
F
Q
---------
K
L
P
DL
A
V
------
Q
A
Q
Q
K
A
---
P
L
D
A
L
R
K
F
L
E
T
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
M
R
L
----------
D
----------
E
A
S
D
R
G
--
R
-
Y
L
M
I
G
A
--
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Fugue
61.16
20%
-58
- C2 -
3HJH
1
MFD_ECOLI
A:
[5-450]
-------------------
Y
R
Y
T
L
P
V
K
A
G
----
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
-------
T
D
Q
M
-
V
M
N
L
-------------
A
D
W
E
T
L
P
Y
D
S
-
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
-------
E
V
---
K
R
---
D
P
E
H
I
Y
Q
Q
-----
V
S
-------
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
-----
F
S
--
E
-
P
L
P
-----
P
L
F
S
Y
F
P
A
N
T
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
--
P
-
M
----
R
-----
P
-----
L
L
P
P
Q
S
L
W
L
R
V
D
E
L
F
S
E
L
K
-
N
----
W
P
R
V
Q
L
K
T
E
H
L
----------
P
T
K
A
A
N
A
N
L
G
F
Q
---------
K
L
P
--
D
L
AVQ---
A
Q
Q
K
A
P
---
L
D
A
L
R
K
F
L
E
T
F
-
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
-
R
I
M
R
----------
L
----------
D
E
A
S
D
R
--
G
R
Y
L
M
I
G
A
--
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
HHSearch
60.30
22%
-55
- C2 -
3HJH
1
MFD_ECOLI
A:
[13-450]
---------------------------
A
G
----
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
-
H
A
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
-------
T
-
D
Q
M
V
M
N
L
-------------
A
D
W
E
T
L
P
Y
D
S
-
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
--------------------
R
D
-----
P
E
H
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
-----
F
S
--
E
P
L
-
P
-----
P
L
F
S
Y
F
P
A
N
T
L
L
--
V
N
--
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
P
M
R
P
-
L
-----
L
-----
P
P
Q
S
--
L
W
L
R
V
D
E
L
F
S
E
L
K
-
N
W
P
R
V
Q
L
K
T
E
H
L
P
T
--------------
K
A
A
N
A
N
L
G
F
Q
---------
K
L
P
--
D
L
AVQAQQ
K
A
P
L
D
A
---
L
R
K
F
L
E
T
F
----
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
-
R
I
M
R
----------
L
----------
D
E
A
S
D
R
--
G
R
Y
L
M
I
G
A
--
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
58.63
21%
-58
- C2 -
1OYW
1
RECQ_ECOLI
A:
[16-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Q
E
T
F
G
Y
Q
Q
F
R
P
G
Q
E
E
I
I
D
T
V
L
S
G
------
R
D
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
Q
I
P
A
L
L
L
------------------------
N
G
L
T
V
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
Q
A
N
------
G
V
A
A
A
C
L
N
S
T
Q
T
R
E
Q
Q
L
E
V
M
T
G
C
R
T
G
Q
I
R
L
L
Y
I
A
P
E
R
L
M
L
-----
D
N
F
L
E
H
---
L
A
H
W
N
P
V
L
L
A
V
D
E
A
H
C
I
S
Q
WGH
D
F
-----
R
P
E
Y
-
A
----
A
L
GQ
L
R
----
Q
----
R
----
F
P
T
L
P
F
M
A
L
T
A
T
A
D
D
T
T
R
Q
D
I
V
R
L
L
G
L
N
D
P
L
-
I
--
Q
I
-----
S
--
S
--
F
-
D
R
P
N
I
R
Y
M
L
M
E
---
K
--
F
--------
K
--
P
L
D
Q
L
M
-----------
R
Y
V
Q
E
Q
R
G
K
S
G
I
I
Y
C
N
S
R
A
K
V
E
D
T
A
A
R
L
-----
Q
S
K
--
G
I
S
A
A
A
Y
H
A
G
L
E
N
N
V
R
A
D
V
Q
E
K
F
Q
R
D
D
L
Q
I
V
V
A
T
V
A
F
G
M
G
I
N
K
P
N
V
R
F
V
V
H
F
D
I
P
R
-
N
I
E
S
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
A
E
A
M
L
F
Y
D
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
HHSearch
57.93
19%
-53
- C2 -
2DB3
3
VASA1_DROME
A:
[76-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
-
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
------
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
DP
H
E
L
E
L
G-------------
R
P
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
-
S
-
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
----
E
C
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
-----
F
V
D
R
TF---
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
---
M
G
F
S
E
D
M
R
----
R
----
I
M
---
T
----
H
----
V
TM--
R
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
--
F
L
K
N
Y
V
F
V
--
A
I
-----
G
IV
G
--
G
-
A
C
S
D
V
K
Q
T
I
Y
E
---
V
--
N
---
K
----
Y
A
-
K
R
S
K
L
I
E
----------
I
L
S
--
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
-----
S
E
K
--
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
-
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
HHSearch
57.82
20%
-55
- C2 -
5ANR
-
DDX6_HUMAN
B:
[117-441]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
G
------
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
D
L
KKD------------------
N
I
Q
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
-
M
G
G
A
K
V
M
A
T
T
G
G
T
N
L
R
D
D
---
I
M
-
R
L
D
D
T
V
H
V
V
I
A
T
P
G
R
I
L
D
-----
L
I
K
K
GV---
A
K
V
D
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
S
---
Q
D
-----
F
V
---
Q
----
I
M
---
E
D
I
I
L
T
----
L
----
P
K
N
R
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
--
H
L
Q
K
P
Y
E
I
--
N
L
-----
M
--
E
E
-
L
-
T
L
K
G
V
T
Q
Y
Y
A
Y
VTE
R
--
Q
---
K
----
V
H
-
C
L
N
T
L
F
-----------
S
-
R
--
L
Q
I
N
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
-----
S
Q
L
--
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
----
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
-
L
A
E
T
Y
L
H
R
I
G
R
S
G
----
L
G
L
A
I
N
L
I
T
Y
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
HHSearch
57.63
18%
-54
- C2 -
4D25
4
?
A:
[71-408]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
------
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
Q
D
PKD
L
I
S
E
NG
C
A
---------
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
-
S
-
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
---
N
-
I
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
R
N
R
--------
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
---
M
G
F----
M
P
S
I
E
K
----
M
M
---
L
----
H
PTMV
E
----
T
T
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
--
F
L
N
N
Y
L
F
V
--
A
V
GIVGG
A
--
S
--
T
-
D
V
E
Q
I
F
I
E
V
T
K
---
Y
--
E
K
--
R
----
N
S
-
L
K
Q
L
I
E
-----------
E
----
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
-----
S
E
Q
--
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
-
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
HHSearch
57.06
20%
-54
- C2 -
1S2M
-
DHH1_YEAST
A:
[67-390]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
G
------
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
K
P
KLN------------------
K
I
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
-
C
-
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
---
I
L
R
-
L
N
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
-----
L
A
S
R
KV---
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
---
R
D
-----
F
K
---
T
I
I
E
Q
I
L
---
S
----
F
----
L
----
P
P
T
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
--
H
L
H
K
P
Y
E
I
--
N
L
-----
M
--
E
--
E
L
T
L
K
G
I
T
Q
Y
Y
A
F
---
V
--
E
---
E
----
R
Q
-
K
L
H
C
L
N
-----------
T
L
F
S
K
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
-----
T
D
L
--
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
-
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
HHSearch
56.97
17%
-69
- C2 -
4LJY
4
PRP5_YEAST
A:
[73-427]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
P
I
Q
S
Q
A
L
P
A
I
M
S
G
------
R
D
V
I
G
I
S
K
T
G
S
G
K
T
I
S
Y
L
L
P
L
L
R
Q
V
K
A
QRPLSKHET------------
G
P
M
G
L
I
L
A
P
T
R
E
L
A
L
Q
I
H
E
E
V
T
K
F
T
E
A
D
T
-
S
I
R
S
V
C
C
T
G
G
S
E
M
K
K
Q
---
I
T
D
L
-
K
R
G
T
E
I
V
V
A
T
P
G
R
F
I
D
-----
I
L
T
LNDGKL
L
S
T
K
R
I
T
F
V
V
M
D
E
A
D
R
L
F
D
---
L
G
F
E
P
Q
I
T
----
Q
----
I
M
---
K
----
T
----
V
----
R
P
D
K
Q
C
V
L
F
S
A
T
F
P
N
K
L
R
S
F
A
V
R
--
V
L
H
S
P
I
S
I
T
I
N
S
-----
K
--
G
--
M
-
V
N
E
N
V
K
Q
K
F
R
I
---
C
HS
E
D
E
K
F
----
D
N
-
L
V
Q
L
I
H
E
R
S
E
F
F
D
E
V
Q
S-------
D
A
K
A
I
I
F
V
S
S
Q
N
I
C
D
F
I
S
K
K
L
-----
L
N
A
--
G
I
V
T
C
A
I
H
A
G
K
P
Y
Q
E
R
L
M
N
L
E
K
F
K
R
E
K
N
S
I
L
L
C
T
E
V
L
S
R
G
L
N
V
P
E
V
S
L
V
I
I
Y
N
A
V
K
-
T
F
A
Q
Y
V
H
T
T
G
R
T
A
R
G
S
R
S
G
T
A
I
T
L
L
L
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
HHSearch
56.94
19%
-58
- C2 -
4PXA
5
DDX3X_HUMAN
A:
[86-433]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
------
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
DGPG
E
A
L
R
A
M
K
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
-
S
-
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
---
R
D
L
-
E
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
G
K
--------
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
V
---
M
G
F----
E
P
Q
I
R
R
----
I
V
---
E
----
Q
----
D
TMPP
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
--
F
L
D
E
Y
I
F
L
--
A
V
-----
G
--
R
VG
S
-
T
S
E
N
I
T
Q
K
V
V
W
---
V
--
E
---
E
SD
K
R
S
F
-
L
L
D
L
L
------------
N
A
T
--
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
-----
Y
H
E
--
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
-
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
56.64
26%
-53
- C2 -
3UWX
-
?
B:
[49-364]
--------------------
L
V
D
G
L
R
L
G
V
----
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
I
S
N
V
I
A
Q
V
N
-
K
P
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
H
S
E
L
K
E
F
-------
F
P
H
N
A
V
E
Y
F
V
S
YYDYYQ
P
E
A
Y
V
P
Q
T
D
T
Y
I
E
K
D
-
A
K
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
V
A
S
V
S
C
I
Y
G
L
G
S
P
E
E
-
Y
R
E
L
V
V
S
L
R
V
G
M
E
I
E
R
N
A
L
L
R
R
L
V
D
I
Q
Y
D
R
N
D
I
D
F
R
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
I
R
V
E
F
F
G
D
E
I
E
R
I
R
E
V
D
A
L
T
G
E
V
L
G
E
R
E
H
V
A
I
F
P
A
S
H
F
V
T
R
E
E
K
M
R
L
A
I
Q
N
I
E
Q
E
L
E
E
R
L
A
E
L
R
A
--------
Q
G
K
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
-----
A
L
--
R
-
P
-
P
GSTPY
T
L
L
D
Y
F
P
D
D
F
L
I
I
V
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
56.53
23%
-54
- C2 -
3V4R
2
UVRB_BACSU
A:
[30-345]
--------------------
L
V
K
G
I
Q
E
G
K
----
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
-
K
P
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
-------
F
P
N
N
A
V
E
Y
F
V
S
YYD
Y
Y
Q
P
EAYV
P
Q
T
D
T
F
I
E
K
D
-
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
C
I
Y
G
L
G
S
P
-
E
E
Y
R
E
M
V
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
--R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
---
N
G
K
L
L
E
A
Q
R
L
E
Q
R
-----
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
-----
T
L
--
R
-
P
-
P
G
S
T
P
Y
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
56.50
23%
-55
- C2 -
2D7D
2
UVRB_BACSU
A:
[24-370]
--------------------
L
V
K
G
I
Q
E
G
K
----
K
H
Q
T
L
L
G
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
-
K
P
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
-------
F
P
N
N
A
V
E
Y
F
V
SYYD
Y
Y
Q
P
EAYV
P
Q
T
D
T
F
I
E
K
D
-
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
R
R
D
V
I
I
I
A
S
V
S
C
I
Y
G
L
G
S
P
-
E
E
Y
R
E
M
V
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
---
N
G
K
L
L
E
A
Q
R
L
E
Q
R
-----
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
-----
T
L
--
R
-
P
-
P
GSTPY
T
L
L
D
Y
F
P
D
D
F
M
I
V
V
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------