@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu00570: (2016-06-02 )
MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDVGFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLFLCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMTEQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQTDRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCLKGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTGASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIAVGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIPIIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTDEELNSVPFGSKLSKFMRRREQNGG
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------.....---....10.----.-......20.--------------..-----.....30..--.----...-..40---------------...-...-..--------50...------.----..---.--.60.---.--..--.-------------..------------------.70--------..--.....------.80..----.....----.---------90..----------....-..------.100.---.----.-----....110....-..-.--.-----120--.--------------........130.------......140...------....150....----------...160.......170--------........----.180.......190..-----..-------------...200---.--.--.....--.---.210......----..220..---.....230.-----------------...--...----240--.........-250....---.---..260-.....--..270.-------------...---...280-----.........290--------.-------......300--.-------......-------310..-----.....-----------.320.----.-----.....330-.....---------------------------....340.......350.--------.--.----.-----....-360---....-..-.370.......------------380.-.-------.....------------------390-.....-..-.-.400-......-------.-------410.......----..420.......430---------......--...440...--.--...450---.-......460.-------......470.......480.-..---..----...490---..---------.-.....500..--.-......510...--....520.-......530-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------MDDSI---G
V
K
R
H
W
I
----W-Q
G
A
F
V
L
I
L
A
--------------
G
V
-----
I
T
K
I
L
S
A
V
Y
--R----V
P
F
-
Q
N
I
V
---------------
G
D
V
-
G
F
Y
-
I
Y
--------
Q
Q
V
Y
P
------
F
----
L
G
---
I
--
A
V
M
L---S--TS--
G
-------------
F
P
------------------
V
I
I
--------
S
K
--
L
M
N
D
Y------SEKNH----
H
T
I
L
K
----
I
---------
S
-
A
L
----------
F
L
S
L
-
I
G
------
I
L
L
F
L
---
C
----
L
-----
Y
LG
A
V
-
P
I
A
L
F-MG-D--
S
-----
H
----
L
--------------
A
V
L
I
Q
V
A
A
Y
A
F
L
------
L
F
P
F
V
A
L
L
R
GGF------Q
G
R
H
E
M
L
P
S
A
L
----------
S
Q
M
T
E
Q
F
L
R
V
A
V
L
L
----------
G
L
S
F
W
L
V
K----KGA
S
L
Y
TAGAAAASG
S
-----
L
A
-------------
G
S
L
V
-----
A
--
L
--
I
I
L
G
F
--
F
---
W
FK-TKRDNQ----TDRQNEN---VI
T
T
K
E
L
T
K
-----------------
K
L
L
--
L
Y
S
----
V
----
T
I
C
V
S
S
L
L
L
-
L
F
I
Q
L
V
D
---
A
---
L
N
L
Y
A
-LLSGG--E
A
S
E
E
A
-------------
K
C
L
---
K
G
I
Y
-------DRG
Q
P
L
L
Q
L
G
S
V
--------
F
-------
A
V
S
I
A
T
S
L
V
--
P
-------
Y
I
S
M
AV-------KN-
K
E
-----
L
K
I
M
K
-----------
E
K
I
T
S
----S-----
L
K
L
C
L
V
---
L
GTGA---------------------------SA
G
L
I
C
I
L
KP
V
N
I
M
L
F
-Q--------N--G----E-----GT
G
A
-
L
Q
V
---
F
S
C
S
-
I
L
-
F
A
S
L
A
V
T
A
A
A
V
------------
L
QGA-G-------
Y
T
V
F
P
------------------
A
---
I
AVG
A
-
G
V
-
A
-
V
K
W
V
-
L
N
T
L
LV-------P-------R--YGIEGA
S
----
L
A
T
A
A
S
F
A
A
V
AG
L
-----------
N
L
Y
Q
L
R
--
Q
K
E
W
L
D
K
L
R
--
G
--
V
L
I
P
I
I
---
G
-
S
A
L
L
M
S
A
V
L
L
-------
A
Y
T
R
L
W
T
F
LFPATGR
G
A
A
-
V
-
I
E
---
S
L
----
S
A
V
AI----
G
G
---------
A
-
V
F
I
Y
C
M
--
M
R
--L-GIFTD
E
E
LNSVP--
F
G
S
K
L
S
K
F
-
M
R
R
R
EQNGG-----------
27
Fugue
75.93
21%
-118
* C6 *
4IWS
-
FDC_PSEAE
A:
[23-515]
----------------------------------------------------------------------------------
M
N
R
S
A
---
L
D
F
R
H
F
V
D
H
L
R
R
-
Q
G
D
L
V
D
V
H
T
--------------
E
V
DANL
E
I
G
A
I
T
R
R
V
Y
--
E
R
RA
P
A
P
L
F
H
N
I
R
---------------
D
S
L
P
G
A
R
-
V
L
G
APAGLRA
D
R
A
R
A
------
H
----
S
R
---
L
--
A
L
H
F
GLP
E
--
H
S
--
G
-------------
P
R
------------------
D
I
V
--------
A
M
--
L
R
A
A
M
R
A
E
P
I
A
P
R
R
L
E
----
R
G
P
V
Q
----
E
---------
N
-
V
W
----------
L
G
E
Q
-
V
D
------
L
T
R
F
P
---
V
----
P
-----
L
L
H
E
Q
-
D
G
G
R
Y
-
F
G
-
T
Y
G
F
-----
H
----
V
--------------
V
Q
T
P
D
G
S
W
D
S
W
S
------
V
G
R
L
M
L
V
D
R
N
T
L
------
A
G
P
-
T
I
P
T
Q
H
I
----------
G
I
I
R
E
Q
W
R
R
L
G
K
P
T
----------
P
W
A
M
A
L
G
A
----
P
P
A
A
L
A
A
A
G
M
P
L
P
E
G
V
-----
S
E
-------------
A
G
Y
V
-----
G
--
A
--
L
V
---------------------------
G
E
P
---
V
E
V
V
R
T
Q
T
N
-----------------
G
L
W
--
V
P
A
----
N
----
T
E
----------
I
V
L
E
G
---
E
---
I
S
L
D
E
-
T
A
L
E
G
--
P
M
G
E
-----------------
Y
---
H
G
Y
S
-------
F
P
I
G
K
P
Q
P
L
F
H
V
--------
H
-------
A
L
S
F
R
D
Q
P
I
--
L
-------
P
I
C
V
A
G
-------
T
P
-
P
E
-----
E
N
H
T
--------------
I
W
G
----
T
-----
M
I
S
A
Q
L
---
L
D
V
A
Q
---------------------------
N
A
G
L
-----
P
V
D
-
M
V
W
-
C
--------
S
--
Y
----
E
-----
A
A
T
C
-
W
A
V
---
L
S
I
D
-
V
Q
R
L
A
A
L
G
T
D
A
A
A
F
------------
A
A
R
V
-
A
-------
E
T
V
F
G
------------------
S
---
H
A
----------------
G
H
L
V
-------
P
-------
K
--
L
I
L
V
G
N
D
----
I
-----------------------
D
V
T
E
I
D
--
Q
V
V
W
A
L
A
T
R
---------------------------------
A
H
P
L
H
D
H
F
A
F
P
Q
I
-
R
D
F
P
-
M
-
V
P
---
Y
L
----
D
A
E
D
K
A
R
GS
G
G
---------
R
-
L
V
I
N
C
L
--
Y
P
--
E
-
Q
F
A
G
Q
M
R
A
A
T
A
S
--
F
R
H
A
Y
P
T
A
-
L
R
R
R
V
E
E
R
W
SDYGF------
31
Fugue
74.25
16%
-106
- C1 -
5FQE
24
?
A:
[28-607]
--------------------------------------------------------------------------------TT
L
G
A
S
I
---
G
S
T
D
F
H
Y
----
L
-
Q
K
D
Y
D
E
I
K
K
LNLN
T
W
N
E
V
A
W
IG
D
E
L
-----
N
S
K
I
V
M
W
T
N
--
S
----
S
P
V
-
N
N
V
T
---------------
L
S
S
-
S
D
F
-
I
N
--------
E
N
G
D
L
------
I
SSNN
I
K
---
I
--
S
W
L
K
---
E
--
T
L
--
A
NIGRSNPS
A
P
L
E
P
F
P
------------------
D
I
I
--------
H
N
--
S
G
S
L
N
------
I
E
K
N
---------
K
----
I
---------
A
-
S
A
----------
W
I
N
I
K
I
P
------
R
N
A
K
P
---
G
----
I
-----
Y
N
G
S
I
-
E
V
T
A
D
-
E
L
-
E
--
K
-----
S
-----------------------
Y
T
F
D
Y
S
F
E
------
V
L
N
L
V
-----------------
Q
P
L
P
S
E
T
----------
N
T
Q
I
E
F
W
Q
H
P
Y
T
I
A
----------
R
Y
Y
K
I
C
K
E
DLFT
E
K
H
F
K
Y
L
R
G
N
L
K
E
Y
R
N
-----
M
G
-------------
G
R
G
V
-----
I
--
A
--
T
I
V
H
E
--
A
---
W
N
H
-
Q
S
Y
D
S
D
P
S
M
I
K
W
R
K
N
S
Y
G
T
F
E
F
D
Y
S
H
F
D
K
-----------------
W
I
Q
--
L
N
I
D
L
GI
L
----
D
P
E
K
G
F
G
Q
I
-
K
C
Y
S
I
V
P
---
W
---
N
N
R
I
Q
-
Y
F
N
E
A
--
T
N
K
E
E
A
-------------
I
N
P
---
T
P
----------
G
S
D
L
W
I
N
I
W
T
Q
--------
F
-------
L
T
S
F
M
S
H
L
E
--
E
K
GWFNI
T
Y
I
S
M
D
E
-------
R
S
-
M
D
D
L
K
A
C
V
D
L
I
E
-----------
N
I
T
N
N
----
S
YE
H
F
K
I
S
S
A
M
D
---
Y
E
S
G
N
---------------------------
D
Y
S
F
L
D
R
I
D
D
I
S
I
G
L
S
-
H
--------
I
--
N
----
H
-----
N
S
D
D
-
M
K
N
---
M
A
T
H
-
R
Q
-
E
L
G
L
L
T
T
I
Y
T
C
TGDYPSSFTISD
P
S
E
G
-
A
-------
F
T
I
W
Y
------------------
S
---
L
Y
Q
N
T
-
N
G
-
F
-
L
R
W
S
-
W
D
G
W
V
E
-------
N
PLENVSY
K
--
Y
W
E
P
G
D
P
----
F
L
I
Y
P
A
E
K
D
S
I
G
K
-----------
T
F
Y
S
T
-----
P
R
L
E
K
L
K
--
E
--
G
I
R
D
I
N
---
K
-
A
K
Y
L
M
E
K
A
P
N
-------
L
K
N
S
I
E
N
L
I
Y
S
L
K
R
P
N
K
G
-
E
-
N
A
---
Y
G
----
S
A
V
A
A
----
S
--------------------
K
E
--
D
-
R
D
L
T
I
S
E
A
N
R
I
K
----
N
G
I
N
N
F
-
A
R
E
F
I
S
L
T
M
-----------
30
Fugue
70.07
15%
-134
* C5 *
4CGY
1
TOP3A_HUMAN
A:
[22-640]
------------------------------------------------------------------------------------
F
S
R
---
A
A
M
E
M
A
L
----
R
-
G
V
R
K
V
L
C
V
A
EK
N
-----------
D
A
-----
A
K
G
I
A
D
L
L
S
--
N
----
G
R
M
-
R
R
R
E
---------------
G
L
S
-
K
F
N
K
I
Y
--------
E
F
D
Y
H
------
L
----
Y
G
Q
N
V
T
--
M
V
M
T
---
S
--
V
S
--
G
-------------
H
-------------------
L
L
A
--------
H
D
--
F
Q
M
Q
F
------
R
K
W
Q
S
----
C
N
P
L
V
----
L
FE
A
E
I
E
K
Y
C
P
-
E
N
----------
F
V
D
I
-
K
K
------
T
L
E
R
E
---
T
----
R
-----
Q
C
Q
A
L
-
V
I
W
T
D
-
C
D
-
R
--
E
-----
G
----
E
--------------
N
I
G
F
E
I
I
H
V
C
K
A
------
V
K
P
N
L
Q
V
L
R
A
R
F
S-----
E
I
T
P
H
A
V
R
T
A
C
----------
E
N
L
T
E
P
D
Q
R
V
S
D
A
V
----------
D
V
R
Q
E
L
D
L
----
R
I
G
A
A
F
T
R
F
Q
T
L
R
L
Q
R
I
F
PEV
L
A
-------------
E
Q
L
I
SYG
S
C
Q
--
F
--
P
T
L
G
F
--
V
---
V
E
R
-
F
K
A
I
Q
A
----
F
V
P
E
I
F
H
---
R
I
K
V
T
H
D
H
K
-----------------
D
G
I
--
V
E
F
----
N
W
KRH
R
L
F
N
H
T
A
C
L
-
V
L
Y
Q
L
C
V
---
E
DP
M
A
T
V
V
E
-
V
R
S
K
P
--
K
S
K
W
R
P
-------------
Q
A
L
D
T
-
V
E
L
E
-------
K
L
A
S
R
K
L
R
I
N
A
K
--------
E
-------
T
M
R
I
A
E
K
L
Y
T
Q
G
-------
Y
I
S
Y
P
R
TETNIFP
R
D
-
L
N
-----
L
T
V
L
V
-----------
E
Q
Q
T
P
DPRW
G
-----
A
F
A
Q
S
I
---
L
E
R
G
G
PTPRNGNKSDQAHPPIHPTKYTNNLQG
D
E
Q
R
L
Y
E
F
I
V
R
H
F
L
A
C
-
C
--------
S
--
Q
----
D
-----
A
Q
G
Q
-
E
T
T
---
V
E
I
D
-
I
A
-
Q
E
R
F
V
A
H
G
L
M
I
------------
L
A
R
N
-
Y
-------
L
D
V
Y
P
------------------
Y
---
D
H
W
S
D
-
K
I
-
L
-
P
V
Y
E
-
Q
G
S
H
F
Q
-------
P
ST-----
V
--
E
M
V
D
G
E
T
S
P
P
K
L
L
T
E
A
D
L
I
A
L
M
E
K
H
GIGTDAT
H
A
E
H
I
E
T
I
K
--
A
R
M
Y
V
G
L
T
P
--
D
K
R
F
L
P
G
H
L
---
G
-
M
G
L
V
E
G
Y
D
S
M
-------
G
Y
E
M
------
S
K
P
D
L
R
A
E
-
L
-
E
A
---
D
L
----
K
L
I
C
D
----
G
K
---------
K
D
K
F
V
V
L
R
--
Q
Q
--
V
-
Q
K
Y
K
Q
V
F
I
E
A
V
A
--
K
A
K
K
L
D
E
A
-
L
A
Q
Y
F
G
N
G
T
-----------
18
HHSearch
67.10
12%
-117
- C4 -
3W4T
9
?
A:
[13-447]
--------------------------------------------------------------------------------------
R
---
G
D
P
K
K
A
I
----
V
-
R
L
S
I
A
M
M
I
G
--------------
M
S
-----
V
Q
T
L
Y
N
L
A
D
--
G
----
I
W
--
V
S
G
L
---------------
G
P
E
-
S
L
A
-
A
V
--------
G
L
F
F
P
------
V
----
F
M
---
G
--
I
I
A
L
A
--
A
G
L
G
V
--
G
-------------
T
S
------------------
S
A
I
--------
A
R
--
R
I
G
A
R
------
D
K
E
G
A
----
D
N
V
A
V
----
H
---------
S
-
L
I
----------
L
S
L
I
-
L
G
------
V
T
I
T
I
---
T
----
M
-----
L
P
A
I
D
-
S
L
F
R
S
-
M
G
A
K
--
G
E
A
V
E
-
L
----
A
--------------
I
E
Y
A
R
V
L
L
A
G
A
F
------
I
I
V
F
N
N
V
G
N
G
I
L
------
R
G
E
G
D
A
N
R
A
M
L
----------
A
M
V
L
G
S
G
L
N
I
V
L
D
P
----------
I
F
I
Y
T
L
-----------
G
F
G
V
V
G
A
A
Y
A
T
-----
L
L
-------------
S
M
V
V
-----
T
--
S
--
L
F
I
A
Y
W
-
L
---
F
V
K
-
R
D
T
Y
V
D
----
I
T
--
L
R
D
---
F
S
P
S
R
E
I
L
K
-----------------
D
I
L
--
R
V
G
----
L
----
P
S
S
L
S
Q
L
S
M
-
S
I
A
M
F
F
L
---
N
---
S
V
A
I
T
-
A
G
G
-----------------------
E
N
G
---
V
A
V
F
-------
T
S
A
W
R
I
T
M
L
G
I
V
--------
P
-------
I
L
G
M
A
A
A
T
T
--
S
-------
V
T
G
A
A
Y
-------
G
E
-
R
N
-----
V
E
K
L
E
-----------
T
A
Y
L
Y
----
A
-----
I
K
I
A
F
M
---
I
E
L
A
V
---------------------------
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
-
Y
-----------------VI
K
G
D
L
I
S
A
-
L
R
T
---
L
P
V
F
-
L
V
-
L
T
P
F
G
M
M
T
S
A
M
------------
F
Q
G
I
-
G
-------
E
G
E
K
S
------------------
L
---
I
L
T
I
F
R
T
L
-
V
-
M
Q
V
G
-
F
A
Y
I
F
V
-------
H
Y
T
-----
T
--
L
G
L
R
G
V
W
----
I
G
I
V
I
G
N
M
V
A
A
I
V
-----------
G
F
L
W
G
R
--
M
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
64.56
19%
-109
- C4 -
4S3Q
7
MALQ_ECOLI
A:
[2-691]
------------------------------------------------------------------------------ES
K
R
L
D
N
A
A
L
A
A
G
I
S
P
N
Y
I
----
N
A
H
G
K
P
Q
S
I
S
A
--------------
E
T
-----
K
R
R
L
L
D
A
M
H
--
Q
----
T
P
V
-
P
N
V
M
V
Y
T
S
G
K
K
M
P
M
V
V
E
G
S
G
E
Y
-
S
W
L
-
L
T
T
EEG
T
---
Q
Y
K
G
H
------
V
----
T
G
---
G
--
K
A
F
N
---
L
--
P
T
--
K
-------------
L
P
E
G
Y
H
T
L
T
L
T
Q
DD
Q
R
A
H
C
R
V
I
V
A
P
KRCYEP
Q
A
--
L
L
N
K
--------
Q
K
L
W
----
G
A
C
V
Q
----
L
---------
Y
-
T
L
RSEKNWGIGD
F
G
D
L
-
K
A
------
M
L
V
D
V
---
A
K
R
GG
S
-----
F
I
G
L
N
-
P
I
H
A
L
-
Y
P
-
A
--
N
-----
P
----
E
SASPYSPSSRRWLN
V
I
Y
I
D
V
N
A
V
E
D
F
------
H
L
S
E
E
A
Q
A
W
W
Q
L
------
P
T
T
Q
Q
T
L
Q
Q
A
R
D
ADWVD
Y
S
T
V
T
A
L
K
M
T
A
L
R
M
A
W
K
G
F
A
Q
RDD
E
Q
M
A
A
F
R
Q
F
V
A
E
----
Q
G
D
S
L
F
W
Q
A
A
F
D
A
L
H
A
-----
Q
Q
-------------
V
K
E
D
-----
E
--
M
--
R
-
W
G
W
--
P
---
A
W
P
-
E
M
Y
Q
N
V
----
D
S
P
E
V
R
Q
---
F
C
E
E
H
R
D
D
V
-----------------
D
F
Y
--
L
W
L
----
Q
----
W
L
A
Y
S
Q
F
A
A
-
C
W
E
I
S
Q
G
Y
EM
P
---
I
G
L
Y
R
-
D
L
A
V
G
VA
E
G
G
A
E
T
-------------
W
C
D
---
R
E
L
Y
CLK
A
S
V
G
A
P
P
D
I
L
G
P
L
G
Q
N
--------
W
G
L
P
P
M
D
P
H
I
I
T
A
R
A
Y
E
--
P
-------
F
I
E
L
L
R
-------
A
N
M
Q
N
-----
C
G
A
L
R
I
----------
D
H
V
M
S
----
M
-----
L
R
L
W
W
I
P--
Y
G
E
T
A
---------------------------
D
Q
G
A
Y
V
H
Y
P
V
D
D
L
L
S
I
-
L
--------
A
--
L
----
E
-----
S
K
R
H
R
C
M
V
---
I
G
E
D
-
L
G
-
T
V
P
V
E
I
V
G
K
L
R
------------
S
S
G
V
Y
S
-------
Y
K
V
L
Y
FENDHEKTFRAPKAYPEQ
S
---
M
A
V
A
A
-
T
H
-
D
-
L
P
-
T
-
L
R
G
Y
W
E
-------
C
-------
G
--
D
L
T
L
G
K
T
----
L
G
L
Y
P
D
E
V
V
L
R
G
L
Y
----------
Q
D
R
E
L
A
--
K
Q
G
L
L
D
A
L
H
K
Y
G
--
C
L
P
K
R
A
---
G
H
K
A
S
L
M
S
M
T
P
T
-------
L
N
R
G
L
Q
R
Y
I
A
D
S
N
S
A
L
L
G
-
L
Q
P
E
---
D
W
L
DMA
E
P
V
N
I
----
P
G
---------
T
-
S
Y
Q
Y
K
N
--
W
R
RK
L
-
S
A
T
L
E
S
M
F
A
D
D
G
--
V
N
K
L
L
K
D
L
-
D
R
R
R
R
S
A
H
------------
32
Fugue
62.90
16%
-117
* C3 *
1IKP
4
TOXA_PSEAE
A:
[2-606]
-----------------------------------------------------------------------------------
E
E
A
F
---
D
L
W
N
E
C
-------
A
K
A
C
V
L
D
L
K
--------------
D
G
-----
V
R
S
S
R
M
S
V
D
--
P
----
A
I
A
-
D
T
-----------------
N
G
Q
-
G
V
L
-
H
Y
--------
S
M
V
L
E
GGND
A
L
K
----
L
A
---
I
DN
A
L
S
I
---
T
--
S
D
--
G
-------------
L
T
------------------
I
R
L
--------
E
G
--
G
V
E
P
N
------
K
P
V
R
Y
----
S
Y
T
R
Q
AR
G
S
W
---------
S
-
L
N
----------
W
L
V
P
-
I
G
HEKPS
N
I
K
V
F
I
---
H
----
E
L
N
AGN
Q
L
S
H
M
S
P
I
Y
T
I
E
M
G
-
D
--
E
-----
L
----
L
--------------
A
K
L
A
R
D
A
T
F
F
V
R
A
H
ESNE
M
Q
P
T
L
A
I
S
H
A
G
V
S
V
V
M
A
Q
K
R
W
S
E
W
A
S
G
K
V
----------
L
C
L
L
D
Q
L
D
G
V
Y
N
Y
L
A
QQRC-----
N
L
D
D
T
W
E
G
----
K
I
Y
R
V
L
A
G
N
P
A
K
H
D
L
D
-----
I
K
PT
V
I
S
H
R
L
H
F
PEG
G
S
L
A
-----
A
--
L
--
T
A
H
Q
A
C
H
L
---
P
L
E
-
T
F
T
R
H
R
----
Q
P
R
G
A
E
Q
---
L
E
Q
C
G
Y
P
V
Q
-----------------
R
L
V
--
A
L
Y
----
L
----
A
A
R
L
S
-------
W
N
Q
V
D
---
Q
---
V
I
R
N
A
-
L
A
S
P
G
--
S
G
G
D
L
G
-------------
E
A
I
---
R
E
Q
P
-------
E
Q
A
R
L
A
L
T
L
A
A
A
--------
E
-------
S
E
R
F
V
R
Q
G
T
--
G
-------
N
D
E
A
G
A
-------
A
N
-
A
D
-----
V
V
S
L
T
-----------
C
P
V
A
A
----
G
-----
E
--
C
A
-----
G
P
A
D
---------------------------
S
G
D
A
L
L
E
R
N
Y
P
T
G
A
E
F
-
L
--------
G
--
D
----
G
-----
G
D
V
S
-
F
S
T
---
R
G
T
Q
-
N
W
-
T
V
E
R
L
L
Q
A
H
R
Q
------------
L
E
E
R
-
G
-------
Y
V
F
V
G
------------------
Y
---
H
G
T
F
L
-
E
A
-
A
-
Q
S
I
V
-
F
G
G
V
R
A
-------
R
-------
S
--
Q
D
L
D
A
I
W
----
R
G
F
Y
I
A
G
D
P
A
L
A
Y
-----------
G
Y
A
Q
D
Q
--
E
P
D
A
R
G
R
I
R
N
-
G
--
A
L
L
R
V
Y
---
V
-
P
R
S
S
L
P
G
F
Y
R
---------
T
S
L
T
L
A
A
P
E
A
A
G
E
V
E
R
-
L
-
I
G
HPL
P
L
----
R
L
D
A
I
----
T
G
P
EEEG
G
R
L
E
T
-
I
L
G
W
P
L
--
A
E
--
R
-
T
V
V
I
P
S
A
I
P
T
D
P
RN
V
G
G
D
L
D
P
S
S
I
P
D
K
E
Q
A
I
S
ALPDYASQPGK
34
Fugue
60.61
19%
-118
- C5 -
4BS9
1
?
A:
[3-781]
PTALQIKPHFHVEIIEP
K
Q
V
Y
L
L
G
EQ
G
N
H
A
L
T
G
Q
L
Y
C
Q
I
LPFLNGEYT
R
E
Q
I
V
E
K
L
DGQVP
E
E
Y
I
D
F
V
L
S
R
L
V
E
K
GYLTEVA
P
E
L
S
L
---
E
V
A
A
F
W
S
----
E
-
L
G
I
A
P
S
V
V
A
--------------
E
G
-----
L
K
Q
P
V
T
V
T
T
A
G
K
----
G
I
R
-
E
G
I
V
---------------
A
N
L
-
A
A
A
-
L
E
--------
E
A
---------------
G
---
I
--
Q
V
S
D
---
P
--
T
A
--
Q
-------------
L
Q
------------------
V
V
L
--------
T
D
DY
L
Q
P
E
L
------
A
A
I
N
K
----
E
A
L
E
R
----
Q
---------
Q
P
W
L
----------
L
V
K
P
-
V
G
------
S
I
L
W
L
----------------
G
---
P
L
F
V
P
-
G
E
-
T
--
G
-----
C
----
W
--------------
H
C
L
A
Q
R
L
Q
G
N
R
E
------
V
E
A
S
V
L
Q
Q
K
R
A
L
------
Q
E
R
P
T
A
R
A
T
L
P
----------
S
T
L
Q
T
G
L
Q
W
A
A
T
E
I
----------
A
K
--
W
M
V
K
----
R
H
L
N
A
I
A
P
G
T
A
R
F
P
-
T
-----
L
A
-------------
G
K
I
F
-----
T
--
F
N
Q
T
T
L
E
L
--
K
---
A
H
P
L
S
R
R
P
Q
C
----
P
T
C
G
D
R
E
---
T
L
Q
R
R
G
F
E
P
L
K
L
E
S
R
P
KHPE
Q
T
V
Q
K
Y
Q
H
L
--
I
G
P
----
I
----
T
G
V
V
T
E
L
V
R
S
R
A
S
G
L
C
E
---
A
---
I
E
R
Y
S
G
I
F
Q
G
D
--
E
P
R
K
R
A
T
LAELGDLAIH
P
E
Q
C
L
HFS
D
R
Q
Y
-------
D
N
R
E
S
S
N
E
R
A
T
V
THDWIPQR
F
-------
D
A
S
K
A
H
D
W
T
--
P
-------
V
W
S
L
T
E
Q------
T
H
-
K
Y
-----
L
P
T
A
L
CYYRYPFPPEH
R
F
C
R
S
----
D
-----
S
N
G
N
A
A
G
NT
L
E
E
A
I
---------------------------
L
Q
G
F
M
E
L
V
E
R
D
S
V
C
L
W
W
Y
--------
N
--
R
----
V
-----
S
R
P
A
-
V
D
L
---
S
S
F
D
E
P
Y
-
F
L
Q
L
Q
Q
F
Y
Q
T
Q
------------
N
R
D
L
-
W
-------
V
L
D
L
T
------------------
A
DLG
I
P
A
F
V
-
G
V
-
S
-
N
R
K
A
-
G
S
S
E
R
I
---------------
I
--
L
G
F
G
A
H
L
----
D
P
T
V
A
I
L
R
A
L
T
E
V
-----------
N
Q
I
G
L
E
LD
A
T
D
W
L
V
N
A
T
--
L
--
A
A
S
P
Y
L
VAD
A
-
S
Q
P
L
K
T
A
K
D
Y
PRRWSDD
I
Y
T
D
V
M
T
C
V
E
I
A
K
Q
A
G
L
E
T
L
-
V
L
---
D
Q
----
T
R
P
D
I
----
G
L
---------
N
-
V
V
K
V
I
V
P
G
M
R
--
F
W
S
R
F
G
S
G
R
L
Y
D
V
P
--
V
K
L
G
W
R
E
Q
-
P
L
A
E
A
Q
M
N
P
TPMPF------
3
PsiBlast_PDB
59.13
19%
-94
- C4 -
3VVN
7
?
A:
[171-420]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
M
V
L
----------
G
S
G
L
N
I
V
L
----
D
P
I
F
I
Y
T
L
G
F
G
V
V
G
A
A
-----
Y
A
--------------
T
L
L
-----
S
--
M
--
V
V
T
S
L
--
F
I
A
Y
W
L
F
-
V
K
R
D
T
Y
----
V
D
I
T
L
R
D
---
F
S
P
S
R
E
I
L
K
-----------------
D
I
L
--
R
V
G
----
L
----
P
S
S
L
S
Q
L
S
M
-
S
I
A
M
F
F
--------
L
N
S
V
A
-
I
T
A
G
G
--
E
N
G
----------------------
V
A
V
F
-------
T
S
A
W
R
I
T
M
L
G
I
V
--------
P
-------
I
L
G
M
A
A
A
T
T
--
S
-------
V
T
G
A
A
Y
-------
G
E
-
R
N
-----
V
E
K
L
E
-----------
T
A
Y
L
Y
----
A
-----
I
K
I
A
F
M
---
I
E
L
-
A
---------------------------
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
-
T
AQVI----
K
--
G
----
D
-----
L
I
S
A
-
L
R
T
---
L
P
V
F
-
L
V
-
L
T
P
F
G
M
M
T
S
A
M
------------
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
R
------------------
T
---
L
V
M
Q
V
-
G
F
-
A
-
Y
I
F
V
-
H
Y
T
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
59.02
12%
-109
- C4 -
5C6N
-
?
A:
[14-441]
-------------------------------------------------------------------------------------------
A
I
P
K
L
L
----
R
-
S
L
S
I
P
A
M
I
G
--------------
M
F
-----
V
M
A
L
Y
N
V
V
N
--
T
----
I
F
I
-
S
Y
A
V
---------------
G
I
E
-
G
V
A
-
G
V
--------
T
I
A
F
P
------
I
----
M
M
---
I
--
M
M
S
M
---
A
G
-
A
L
G
I
G
-------------
G
A
------------------
S
V
I
--------
S
R
--
R
L
G
E
R
------
R
G
E
E
A
----
N
Q
V
F
G
----
N
---------
I
-
L
T
----------
V
I
L
V
-
L
S
------
V
I
G
F
I
---
S
----
A
-----
F
T
L
L
G
-
P
A
L
Q
L
-
F
G
A
T
--
S
-----
V
T
Q
G
Y
A
--------------
T
D
Y
L
F
P
I
L
L
G
S
I
------
F
F
F
F
A
F
A
A
N
N
I
I
------
R
S
E
G
N
A
T
F
A
M
V
----------
T
M
I
V
P
A
V
L
N
I
L
L
D
V
----------
L
F
I
F
G
L
-----------
N
M
G
V
L
G
A
S
I
A
T
-----
V
I
-------------
A
Q
A
S
-----
V
--
T
--
G
L
V
L
R
--
Y
---
F
L
T
-
G
K
S
T
L
S
----
L
H
--
W
S
D
---
L
R
M
K
G
S
V
I
K
-----------------
E
V
C
--
L
V
G
----
L
----
P
A
F
V
Q
Q
S
S
A
-
S
L
M
M
I
A
I
---
N
---
S
M
L
L
R
-
F
G
S
-----------------------
D
F
Y
---
V
G
V
F
-------
G
L
V
Q
R
I
M
M
F
V
M
M
--------
P
-------
M
M
G
I
M
Q
A
M
Q
--
P
-------
I
V
G
Y
N
Y
-------
G
A
-
K
Q
-----
Y
S
R
L
R
-----------
E
T
V
M
L
----
G
-----
F
K
V
A
T
I
---
F
S
I
G
I
---------------------------
F
A
L
L
M
L
F
P
E
A
L
L
R
V
F
T
-
A
--------
D
--
R
E
V
I
Q
A
-----
G
V
S
A
-
M
H
I
---
L
F
C
V
-
T
F
-
L
I
G
A
Q
I
V
A
G
G
L
------------
Y
Q
S
L
-
G
-------
K
P
K
Q
A
------------------
L
---
I
L
S
L
S
-
R
Q
-
I
-
I
F
L
I
P
L
V
L
I
L
P
-------
H
-------
I
--
F
G
L
S
G
V
W
----
W
A
F
P
I
A
D
V
L
S
F
I
L
-----------
T
V
V
L
L
Y
--
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
58.55
19%
-97
- C4 -
3W4T
7
?
A:
[171-420]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
M
V
L
----------
G
S
G
L
N
I
V
L
----
D
P
I
F
I
Y
T
L
G
F
G
V
V
G
A
A
-----
Y
A
--------------
T
L
L
-----
S
--
M
--
V
V
T
S
L
--
F
I
A
Y
W
L
F
-
V
K
R
D
T
Y
----
V
D
I
T
L
R
D
---
F
S
P
S
R
E
I
L
K
-----------------
D
I
L
--
R
V
G
----
L
----
P
S
S
L
S
Q
L
S
M
-
S
I
A
M
F
F
--------
L
N
S
V
A
-
I
T
A
G
G
--
E
N
G
----------------------
V
A
V
F
-------
T
S
A
W
R
I
T
M
L
G
I
V
--------
P
-------
I
L
G
M
A
A
A
T
T
--
S
-------
V
T
G
A
A
Y
-------
G
E
-
R
N
-----
V
E
K
L
E
-----------
T
A
Y
L
Y
----
A
-----
I
K
I
A
F
M
---
I
E
L
-
A
---------------------------
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
-
T
YVI-----
K
--
G
----
D
-----
L
I
S
A
-
L
R
T
---
L
P
V
F
-
L
V
-
L
T
P
F
G
M
M
T
S
A
M
------------
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
R
------------------
T
---
L
V
M
Q
V
-
G
F
-
A
-
Y
I
F
V
-
H
Y
T
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
58.14
20%
-105
- C6 -
1SQ9
2
SKI8_YEAST
A:
[3-395]
------------------------------------------------------------------------------------------------------------------------------
K
V
-----
F
I
A
T
A
N
A
--------------------------------
G
K
A
-
H
D
A
-
D
I
--------
F
S
V
S
A
------
C
----
N
S
---
F
--
T
V
S
C
---
S
--
G
D
--
G
-------------
Y
L
------------------
K
V
W
D
-------
N
K
--
L
L
D
N
E
------
N
P
K
D
K
----
S
Y
S
H
F
----
V
---------
H
-
K
S
----------
G
L
H
H
-
V
D
------
V
L
Q
A
I
ERD
A
----
F
-----
E
L
C
L
V
-
A
T
T
S
F
-
S
G
-
D
--
L
-----
L
----
F
--------------
Y
R
I
T
R
E
D
E
T
K
K
V
------
I
F
E
K
L
D
L
L
D
S
D
M
------
K
K
H
--------------------------------------------
S
F
W
A
L
K
----
W
G
A
S
--------
N
S
H
R
-----
L
V
-------------
A
T
D
V
-----
K
G
T
T
--
Y
I
W
K
F
--
H
---
P
F
A
-
D
E
S
N
S
L
----
T
L
N
W
S
P
T
---
L
E
L
Q
G
T
V
E
S
-----------------
P
M
T
PS
Q
F
A
----
T
----
S
V
D
I
S
E
R
G
L
-
I
A
T
G
F
N
N
-----------------------------------------------------------------
G
T
V
--------
Q
-------
I
S
E
L
S
T
L
R
P
--
L
-------
Y
N
F
E
S
Q
-------
H
N
-
N
S
-----
N
S
I
R
S
-----------
V
K
F
S
P
----
Q
-----
G
S
L
L
A
I
---
A
H
D
S
N
---------------------------
S
F
G
C
I
T
L
Y
E
T
-------
E
--------
F
--
G
----
E
-----
R
I
G
S
-
L
S
V
PGE
F
A
H
S
-
S
W
-
V
M
S
L
S
F
N
D
--------------------------------------------------------------------------------------------------
S
G
E
T
----
L
C
S
A
G
W
D
G
-------------------
K
L
R
--
F
W
D
V
K
T
K
E
R
--
I
--
T
T
L
N
M
H
---
C
-
D
D
I
E
I
E
E
D
I
L
-------
A
V
D
E
H
G
----------------
D
---
S
L
----
A
E
P
G
V
----
F
D
---------
V
-
K
F
L
K
K
G
--
W
R
--
S
-
G
M
G
A
D
--
L
N
E
S
L
--
C
C
V
C
L
D
R
S
-
I
R
W
F
R
E
A
G
------------
7
PsiBlast_PDB
57.43
19%
-96
- C4 -
3WBN
6
?
A:
[171-420]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
M
V
L
----------
G
S
G
L
N
I
V
L
----
D
P
I
F
I
Y
T
L
G
F
G
V
V
G
A
A
-----
Y
A
--------------
T
L
L
-----
S
--
M
--
V
V
T
S
L
--
F
I
A
Y
W
L
F
-
V
K
R
D
T
Y
----
V
D
I
T
L
R
D
---
F
S
P
S
R
E
I
L
K
-----------------
D
I
L
--
R
V
G
----
L
----
P
S
S
L
S
Q
L
S
M
-
S
I
A
M
F
F
--------
L
N
S
V
A
-
I
T
A
G
G
--
E
N
G
----------------------
V
A
V
F
-------
T
S
A
W
R
I
T
M
L
G
I
V
--------
P
-------
I
L
G
M
A
A
A
T
T
--
S
-------
V
T
G
A
A
Y
-------
G
E
-
R
N
-----
V
E
K
L
E
-----------
T
A
Y
L
Y
----
A
-----
I
K
I
A
F
M
---
I
E
L
-
A
---------------------------
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
-
T
YSESAQVI
K
--
G
----
D
-----
L
I
S
A
-
L
R
T
---
L
P
V
F
-
L
V
-
L
T
P
F
G
M
M
T
S
A
M
------------
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
R
------------------
T
---
L
V
M
Q
V
-
G
F
-
A
-
Y
I
F
V
-
H
Y
T
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
57.37
10%
-126
- C4 -
4Z3N
7
?
A:
[27-456]
-------------------------------------------------------------------------------------------
S
L
Y
K
L
L
----
L
-
R
M
A
L
P
M
F
V
G
--------------
M
L
-----
T
Q
V
T
Y
A
I
A
D
--
I
----
F
W
L
-
S
H
-------------------
G
-
I
I
A
-
G
V
--------
G
L
V
F
P
------
V
----
G
M
---
G
--
L
F
A
I
------
A
N
--
G
-------------
I
Q
------------------
I
G
M
--------
G
S
--
L
L
S
R
A
------
I
G
M
Q
R
LDR
A
Q
R
I
L
S
----
V
---------
G
-
I
I
----------
I
A
L
F
-
F
A
------
I
V
I
T
V
---
L
----
G
-----
Y
V
Y
A
Q
-
P
L
L
R
S
-
L
G
-
A
--
T
KSII
G
Y
----
A
--------------
T
E
F
Y
Y
Y
S
L
L
T
V
F
------
S
I
M
L
I
G
V
M
M
G
L
F
------
Q
G
A
G
K
I
M
V
I
M
K
----------
A
S
L
L
G
A
L
V
N
I
M
L
D
P
----------
I
M
I
F
V
F
-----------
D
F
G
V
K
G
V
A
L
A
S
-----
F
L
-------------
A
Q
L
S
-----
M
--
V
--
A
Y
F
I
Y
--
T
---
L
M
G
------------------------
S
W
K
I
Y
R
-----------------
E
F
L
--
S
V
G
----
M
----
A
Q
M
L
M
Q
L
I
I
-
A
V
G
I
V
I
Y
---
N
---
F
F
I
V
R
-
L
-
D
-----------------------
V
N
A
---
M
A
A
F
-------
T
L
T
G
R
I
D
Y
F
I
I
T
--------
P
-------
M
L
A
I
A
T
A
L
L
--
T
-------
V
V
G
Q
N
W
-------
G
H
-
G
N
-----
V
T
R
T
L
-----------
N
A
Y
W
A
----
A
-----
V
A
L
A
F
S
---
I
V
L
V
L
---------------------------
A
V
M
H
I
V
L
A
P
W
M
Y
P
L
F
T
-
R
--------
V
--
V
A
V
S
D
Y
-----
A
V
L
Q
-
T
R
I
---
M
A
L
A
-
L
P
-
F
V
A
I
S
L
L
A
S
E
Y
------------
Y
Q
A
I
-
G
-------
K
P
W
Y
S
------------------
V
---
L
L
T
L
M
-
R
H
V
F
-
I
S
V
P
-
V
V
Y
L
L
A
IV-----
L
-------
E
--
M
R
I
T
G
V
Y
----
F
G
A
M
S
G
T
F
V
A
A
L
L
-----------
A
W
R
L
L
R
--
L
--------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
57.34
20%
-99
- C4 -
4MLB
17
?
A:
[178-427]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
M
V
L
----------
G
S
G
L
N
I
V
L
----
D
P
I
F
I
Y
T
L
G
F
G
V
V
G
A
A
-----
Y
A
--------------
T
L
L
-----
S
--
M
--
V
V
T
S
L
--
F
I
A
Y
W
L
F
-
V
K
R
D
T
Y
----
V
D
I
T
L
R
D
---
F
S
P
S
R
E
I
L
K
-----------------
D
I
L
--
R
V
G
----
L
----
P
S
S
L
S
Q
L
S
M
-
S
I
A
M
F
F
--------
L
N
S
V
A
-
I
T
A
G
G
--
E
N
G
----------------------
V
A
V
F
-------
T
S
A
W
R
I
T
M
L
G
I
V
--------
P
-------
I
L
G
M
A
T
A
T
T
--
S
-------
V
T
G
A
A
Y
-------
G
E
-
R
N
-----
V
E
K
L
E
-----------
T
A
Y
L
Y
----
A
-----
I
K
I
A
F
M
---
I
E
L
-
A
---------------------------
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
-
T
Y
S
E
SAQVI
K
--
G
----
D
-----
L
I
S
A
-
L
R
T
---
L
P
V
F
-
L
V
-
L
T
P
F
G
M
M
T
S
A
M
------------
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
R
------------------
T
---
L
V
M
Q
V
-
G
F
-
A
-
Y
I
F
V
-
H
Y
T
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
56.15
19%
-94
- C4 -
3VVS
11
?
A:
[171-420]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
M
V
L
----------
G
S
G
L
N
I
V
L
----
D
P
I
F
I
Y
T
L
G
F
G
V
V
G
A
A
-----
Y
A
--------------
T
L
L
-----
S
--
M
--
V
V
T
S
L
--
F
I
A
Y
W
L
F
-
V
K
R
D
T
Y
----
V
D
I
T
L
R
D
---
F
S
P
S
R
E
I
L
K
-----------------
D
I
L
--
R
V
G
----
L
----
P
S
S
L
S
Q
L
S
M
-
S
I
A
M
F
F
--------
L
N
S
V
A
-
I
T
A
G
G
--
E
N
G
----------------------
V
A
V
F
-------
T
S
A
W
R
I
T
M
L
G
I
V
--------
P
-------
I
L
G
M
A
A
A
T
T
--
S
-------
V
T
G
A
A
Y
-------
G
E
-
R
N
-----
V
E
K
L
E
-----------
T
A
Y
L
Y
----
A
-----
I
K
I
A
F
M
---
I
E
L
-
A
---------------------------
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
-
T
I-------
K
--
G
----
D
-----
L
I
S
A
-
L
R
T
---
L
P
V
F
-
L
V
-
L
T
P
F
G
M
M
T
S
A
M
------------
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
R
------------------
T
---
L
V
M
Q
V
-
G
F
-
A
-
Y
I
F
V
-
H
Y
T
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
54.99
19%
-102
- C4 -
3VVP
1
?
A:
[171-420]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
M
V
L
----------
G
S
G
L
N
I
V
L
----
D
P
I
F
I
Y
T
L
G
F
G
V
V
G
A
A
-----
Y
A
--------------
T
L
L
-----
S
--
M
--
V
V
T
S
L
--
F
I
A
Y
W
L
F
-
V
K
R
D
T
Y
----
V
D
I
---
D
---
F
S
P
S
R
E
I
L
K
-----------------
D
I
L
--
R
V
G
----
L
----
P
S
S
L
S
Q
L
S
M
-
S
I
A
M
F
F
--------
L
N
S
V
A
-
I
T
A
G
G
--
E
N
G
----------------------
V
A
V
F
-------
T
S
A
W
R
I
T
M
L
G
I
V
--------
P
-------
I
L
G
M
A
A
A
T
T
--
S
-------
V
T
G
A
A
Y
-------
G
E
-
R
N
-----
V
E
K
L
E
-----------
T
A
Y
L
Y
----
A
-----
I
K
I
A
F
M
---
I
E
L
-
A
---------------------------
V
V
A
F
I
M
L
---------------------------
D
-----
L
I
S
A
-
L
R
T
---
L
P
V
F
-
L
V
-
L
T
P
F
G
M
M
T
S
A
M
------------
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
R
------------------
T
---
L
V
M
Q
V
-
G
F
-
A
-
Y
I
F
V
-
H
Y
T
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
54.16
19%
-98
- C4 -
3VVO
9
?
A:
[171-420]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
M
V
L
----------
G
S
G
L
N
I
V
L
----
D
P
I
F
I
Y
T
L
G
F
G
V
V
G
A
A
-----
Y
A
--------------
T
L
L
-----
S
--
M
--
V
V
T
S
L
--
F
I
A
Y
W
L
F
-
V
K
R
D
T
Y
----
V
D
I
T
L
R
D
---
F
S
P
S
R
E
I
L
K
-----------------
D
I
L
--
R
V
G
----
L
----
P
S
S
L
S
Q
L
S
M
-
S
I
A
M
F
F
--------
L
N
S
V
A
-
I
T
A
G
G
--
E
N
G
----------------------
V
A
V
F
-------
T
S
A
W
R
I
T
M
L
G
I
V
--------
P
-------
I
L
G
M
A
A
A
T
T
--
S
-------
V
T
G
A
A
Y
-------
G
E
-
R
N
-----
V
E
K
L
E
-----------
T
A
Y
L
Y
----
A
-----
I
K
I
A
F
M
---
I
E
L
-
A
---------------------------
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
-
T
YI------
K
--
G
----
D
-----
L
I
S
A
-
L
R
T
---
L
P
V
F
-
L
V
-
L
T
P
F
G
M
M
T
S
A
M
------------
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
R
------------------
T
---
L
V
M
Q
V
-
G
F
-
A
-
Y
I
F
V
-
H
Y
T
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
52.13
12%
-104
- C4 -
3MKT
-
?
A:
[8-447]
--------------------------------------------------------------------------------------
Y
---
K
K
E
A
S
N
L
----
I
-
K
L
A
T
P
V
L
I
A
--------------
S
V
-----
A
Q
T
G
M
G
F
V
D
--
T
----
I
M
A
-
G
G
-
V
---------------
S
A
I
-
D
M
A
-
A
V
--------
S
I
A
A
S
------
I
----
W
L
---
P
--
S
I
-
L
---
F
--
G
V
--
G
-------------
L
L
------------------
M
A
L
--------
V
P
--
V
V
A
Q
L
------
N
G
A
G
R
QHK
I
P
F
E
V
H
----
Q
---------
G
-
L
I
----------
L
A
L
L
-
V
S
------
V
P
I
I
A
---
V
----
L
------
F
Q
T
Q
-
F
I
I
R
F
-
M
D
V
E
--
E
AMAT-
K
----
T
--------------
V
G
Y
M
H
A
V
I
F
A
V
P
------
A
Y
L
L
F
Q
A
L
R
S
F
T
------
D
G
M
S
L
T
K
P
A
M
V
----------
I
G
F
I
G
L
L
L
N
I
P
L
N
W
----------
I
F
V
Y
G
K
F
-------
G
A
P
E
L
G
G
V
G
C
G
V
A
T
-----
A
I
-------------
V
Y
W
I
-----
M
--
L
--
L
L
L
L
F
--
Y
---
I
V
T
-
S
K
R
L
A
H
----
V
K
V
F
E
T
F
---
H
K
P
Q
P
K
E
L
I
-----------------
R
L
F
--
R
L
G
----
F
----
P
V
A
A
A
L
F
F
E
-
V
T
L
F
A
V
V
---
A
---
L
L
V
A
P
-
L
-
G
-----------------------
S
T
V
---
V
A
A
H
-------
Q
V
A
L
N
F
S
S
L
V
F
M
--------
F
-------
P
M
S
I
G
A
A
V
S
--
I
-------
R
V
G
H
K
L
-------
G
E
-
Q
D
-----
T
K
G
A
A
-----------
I
A
A
N
V
----
G
-----
L
M
T
G
L
A
---
T
A
C
I
T
---------------------------
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
-
E
--------
N
--
Q
VV
V
A
L
-----
A
M
Q
L
-
L
L
F
---
A
A
I
Y
-
Q
C
-
M
D
A
V
Q
V
V
A
A
G
S
------------
L
R
G
Y
-
K
-------
D
M
T
A
I
------------------
F
---
H
R
T
F
I
-
S
Y
W
V
-
L
G
L
P
-
T
G
Y
I
L
G
M
TNWLTE
Q
-------
P
--
L
G
A
K
G
F
W
----
L
G
F
I
I
G
L
S
A
A
A
L
M
-----------
L
G
Q
R
L
Y
--
W
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
49.67
14%
-106
- C4 -
5C6P
1
?
A:
[9-444]
--------------------------------------------------------------------------------------
F
---
L
K
E
I
R
L
L
----
T
-
A
L
A
L
P
M
L
L
A
--------------
Q
V
-----
A
Q
V
G
I
G
F
V
D
--
T
----
V
M
A
-
G
G
-
A
---------------
G
K
E
-
D
L
A
-
A
V
--------
A
L
G
S
S
------
A
----
F
A
---
T
--
V
Y
-
I
---
T
--
F
M
--
G
-------------
I
M
------------------
A
A
L
--------
N
P
--
M
I
A
Q
L
------
Y
G
A
G
K
T
G
E
A
G
E
T
G
R
----
Q
---------
G
-
I
W
----------
F
G
L
I
-
L
G
------
I
F
G
M
I
---
L
----
M
-----
W
A
A
I
T
-
P
F
R
N
W
-
L
T
L
S
--
D
YVEG-
T
----
M
--------------
A
Q
Y
M
L
F
T
S
L
A
M
P
------
A
A
M
V
H
R
A
L
H
A
Y
A
------
S
S
L
N
R
P
R
L
I
M
L
----------
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
----------
I
F
V
Y
G
K
F
-------
G
M
P
A
L
G
G
A
G
C
G
V
A
T
-----
M
A
-------------
V
F
W
F
-----
S
--
A
--
L
A
L
W
I
--
Y
---
I
A
K
-
E
K
F
F
R
P
----
F
G
L
T
A
K
F
---
G
K
P
D
W
A
V
F
K
-----------------
Q
I
W
--
K
I
G
----
A
----
P
I
G
L
S
Y
F
L
E
-
A
S
A
F
S
F
I
---
V
---
F
L
I
A
P
-
F
-
G
-----------------------
E
D
Y
---
V
A
A
Q
-------
Q
V
G
I
S
L
S
G
I
L
Y
M
--------
I
-------
P
Q
S
V
G
S
A
G
T
--
V
-------
R
I
G
F
S
L
-------
G
R
-
R
E
-----
F
S
R
A
R
-----------
Y
I
S
G
V
----
S
-----
L
V
S
G
W
V
---
L
A
V
I
T
---------------------------
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
-
D
--------
D
--
P
AVLS
I
-----
A
S
T
V
-
L
L
F
---
A
G
L
F
-
Q
P
-
A
D
F
T
Q
C
I
A
S
Y
A
------------
L
R
G
Y
-
K
-------
V
T
K
V
P
------------------
M
---
F
I
H
A
A
-
A
F
-
W
G
C
G
L
L
-
P
G
Y
L
L
A
-------
Y
-------
R
FD
M
G
I
Y
G
F
W
----
T
A
L
I
A
S
L
T
I
A
A
V
A
-----------
L
V
W
C
L
E
--
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
48.91
15%
-89
- C4 -
3W4T
8
?
A:
[14-216]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
P
K
K
-----------------
A
I
V
--
R
L
S
----
I
----
A
M
M
I
G
M
S
V
Q
-
T
L
Y
N
L
A
D
---
G
---
I
W
V
S
G
--
L
G
-----------------------
P
E
S
---
L
A
A
V
-------
G
L
F
F
P
V
F
M
G
I
I
A
--------
L
-------
A
A
G
L
G
V
G
T
S
--
S
-------
A
I
A
R
R
I
-------
G
A
-
R
D
-----
K
E
G
A
D
-----------
N
V
A
V
H
----
S
-----
L
I
L
S
L
I
---
L
G
V
T
I
---------------------------
T
I
T
M
L
P
A
I
D
S
L
F
R
S
-
M
-
G
--------
A
KG
E
A
V
E
-
L
-----
A
I
E
Y
-
A
R
V
---
L
L
A
G
-
A
F
-
I
I
V
F
N
N
V
G
N
G
I
------------
L
R
G
E
-
G
-------
D
A
N
R
A
------------------
M
---
L
A
M
V
L
-
G
S
-
G
-
L
N
I
V
-
L
D
P
I
F
I
-------
Y
TL-----
G
--
F
G
V
V
G
A
A
----
Y
A
T
L
L
S
M
V
V
T
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------